CN108836237B - Sampling capsule with sampling pool sealing structure - Google Patents
Sampling capsule with sampling pool sealing structure Download PDFInfo
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- CN108836237B CN108836237B CN201810617882.4A CN201810617882A CN108836237B CN 108836237 B CN108836237 B CN 108836237B CN 201810617882 A CN201810617882 A CN 201810617882A CN 108836237 B CN108836237 B CN 108836237B
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- 238000005070 sampling Methods 0.000 title claims abstract description 211
- 239000002775 capsule Substances 0.000 title claims abstract description 112
- 238000007789 sealing Methods 0.000 title claims abstract description 54
- 239000003814 drug Substances 0.000 claims abstract description 57
- 238000010438 heat treatment Methods 0.000 claims description 20
- 238000004891 communication Methods 0.000 claims description 10
- 230000000903 blocking effect Effects 0.000 claims description 9
- 239000004831 Hot glue Substances 0.000 claims description 7
- 230000006835 compression Effects 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 3
- 238000013461 design Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to a sampling capsule with a sampling pool sealing structure, which comprises a capsule shell, a piston, a spring, a waterproof cover, a heater, a capsule sensing and controlling module, a spring supporting ring, a sampling hole plugging piece and a fusible spring fastening piece, wherein the outer ring of the spring supporting ring is fixedly connected with the inner wall of the capsule shell in a sealing way, the inner ring of the spring supporting ring is fixedly connected with the opening part of the waterproof cover in a sealing way, an electric control element bin is separated from the sampling pool in a sealing way by the spring supporting ring and the waterproof cover, the sampling pool is separated from a medicine bin in a sealing way by the piston, a medicine releasing hole is formed in the capsule shell and sealed by a sealing plug, a through hole which can be communicated with the medicine releasing hole is formed in a medicine bin sealing plate of the medicine bin, the through hole is oil-sealed, the capsule sensing and controlling module is arranged in the electric control element bin, and the heater is arranged in the waterproof cover. The invention has the functions of sampling and releasing simultaneously, is in an active mode, and has stronger sampling power and better controllability.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a sampling capsule with a sampling pool sealing structure.
Background
The ideal structure of the sampling capsule is that the sampling pool is closed before sampling and is not contacted with the outside, so that the cleaning of the sampling pool is kept; the sampling pool is open enough during sampling to ensure that the sample of interest can be successfully and sufficiently taken in; after the sampling is finished, the sampling pool is sealed again, so that the samples can be prevented from leaking, and the samples are prevented from being polluted in the process that the capsule system is discharged outside the body. The sample cell in many current designs cannot be re-blocked and thus there is a potential for sample leakage or contamination (e.g., gu and Gu,1996, reference "Ingestibel Gastrointestinal SAMPLING DEVICES: state-of-the-Art and Future Directions").
Aiming at the problems, the Chinese patent with publication number CN1820798A discloses a capsule system for simultaneously sampling and releasing medicine by using a spring, wherein a piston blocks a one-way valve before sampling, and a sampling pool is closed. After sampling begins, the spring pushes the piston to move rightwards, and the pressure difference enables external liquid to enter the sampling tank through the one-way valve. After the sampling is finished, the valve plate of the one-way valve closes the valve under the action of self elasticity. This patent essentially meets the need for a closed sampling cell, but the design suffers from the following drawbacks: first, the patent does not specify the structure of the check valve; secondly, when the external pressure is increased, the one-way valve cannot prevent substances at other parts from reentering the capsule;
Chinese patent publication CN201719266U, a micro-alimentary canal liquid sampling device, discloses a passive sampling capsule system using a micro-motor, in one solution of which the sampling pool can be rotated under the drive of the micro-motor. The sampling pool opening is staggered with the sampling opening of the capsule shell before sampling, and the sampling pool is sealed. When in sampling, the micro motor drives the sampling pool to rotate, the sampling pool is aligned with the sampling port, and the passive absorption of body fluid is started. After the sampling is finished, the micro motor drives the sampling pool to rotate again, the sampling ports are staggered again, and the sampling pool is sealed. In another scheme of the patent, the micro motor converts rotation into linear motion through a transmission mechanism, sampling ports are staggered at the beginning, a sampling pool is pushed during sampling to align the sampling ports, and the sampling ports are staggered after sampling. The proposal has better controllability by means of the micro motor, but has the following defects: the first and the closing modes depend on a micro motor, and the micro motor has small power, large volume and high energy consumption; the second, sampling mode is passive sampling, the absorption rate is slow; third, the system has no release function.
The Chinese patent with publication number CN106725634A discloses a capsule collection system using degradable material and spring, which is degraded in specific digestive juice to release the spring, extend it and push the piston. Before sampling, the sampling hole is sealed by a plug made of the same degradable material. When sampling is carried out, the plug is degraded firstly, and liquid enters the capsule through the sampling hole. Due to the gradual degradation of the degradable portion, the spring pushes the piston to seal the liquid into the sampling cell. With further degradation, the wire bolt moves to the sampling hole, and under the action of elastic force, the wire bolt pops up to clamp the sampling hole, the sampling pool is closed, and the sampling is finished. The structural disadvantage is that: firstly, degradation materials are used as a trigger mechanism, and the specific trigger time is difficult to control; secondly, the sampling target is limited by degradable materials, the property of the target liquid needs to be known in advance, and a proper degradable material is selected; thirdly, passively sampling; fourth, the release function is not provided.
The Chinese patent with publication number CN201453300U discloses a pneumatic sampling capsule system, which is triggered to blow an easy-fuse wire to release a spring to push a thimble to puncture an air bag. The air bag is deflated and sprayed out from the right air vent hole. The air bag is contracted, and the contraction process of the left air bag generates low pressure to absorb body fluid through the sampling hole. The sampling port is provided with a switch, which consists of a plug, a spring and a thin wire. Before sampling, the plug is in an open state under the action of the elasticity of the spring, and the thin wire is loosened. During sampling, the balloon pulls the thin wire to the right continuously and straightens the thin wire gradually. The thin wire overcomes the spring, pulls the plug, plugs the sampling hole, and the sampling is finished. The design adopts a pneumatic mode, and the triggering is completed by a compression spring. The structural disadvantage is that: firstly, the sampling pool is sealed by an inflated air bag before sampling, but the air bag is still in contact with the outside in practice; secondly, the plug is in an ejected state before sampling is finished, so that the ingestion of the capsule and the movement in the digestive tract are not facilitated; third, the release function is not provided.
Disclosure of Invention
The invention aims to provide a sampling capsule with a sampling pool sealing structure, which has the functions of sampling and releasing, is in an active mode, and has stronger sampling power and better controllability.
In order to solve the technical problems, the invention discloses a sampling capsule with a sampling pool sealing structure, which is characterized in that: the capsule comprises a capsule shell, a piston, a spring, a waterproof cover, a heater, a capsule sensing and control module, a spring supporting ring, a sampling hole plugging piece and a fusible spring fastener, wherein the outer ring of the spring supporting ring is fixedly connected with the inner wall of the capsule shell in a sealing way, the inner ring of the spring supporting ring is fixedly connected with the opening part of the waterproof cover in a sealing way, the capsule shell comprises an electric control element bin, a sampling pool and a medicine bin, the electric control element bin is separated from the sampling pool in a sealing way by the spring supporting ring and the waterproof cover in a sealing way, the sampling pool is separated from the medicine bin in a sealing way by the piston, a medicine releasing hole is formed in the capsule shell, the medicine releasing hole is sealed by a sealing plug, a through hole which can be communicated with the medicine releasing hole is formed in a medicine bin sealing plate, an oil seal is adopted by the through hole, the capsule sensing and control module is arranged in the electric control element bin, the heater is arranged in the waterproof cover, the spring is located in the sampling pool, one end of the spring is connected with the spring supporting ring, the other end of the spring is connected with the piston, the spring is limited in a compression state by the fusible spring fastener, the heating head of the fusible spring fastener can be heated, the fusible spring fastener can be fastened in the compression state, the piston is arranged on the piston, the sampling hole is separated from the sampling hole, the medicine hole is sealed by the piston, the piston is provided with the piston, the sampling hole and the sampling hole is completely and the sampling hole and can be completely connected with the sampling hole and the sampling hole.
The invention has the beneficial effects that:
1. The invention can sample and release medicine at the same time; the sampling and drug release are required functions of biomedical research, treatment and the like, when a user needs to know the conditions of microorganisms, physiological parameters and the like in a specific digestive tract system and release the drug to the location, one capsule can be completed, and two operations are ensured to be completed in the same digestive tract area. Avoiding taking multiple capsules and avoiding taking multiple capsules is easy to have positioning errors.
2. The invention designs an active mode for sampling and releasing, wherein the active mode is a mode of containing a specific power source and driving the device to act under an instruction. The opposite "passive mode" generally refers to: the sample is adsorbed by the water-absorbing material, and the medicine is automatically permeated and flowed into the digestive tract by opening the medicine storage room. Thus, the active approach has several benefits:
2.1, the operability is stronger, and the method can be started according to a preset program or an operation instruction;
2.2, containing driving force, the sampling and releasing speed can be expected, and the method is quicker, less in delay and higher in positioning precision.
3. The sampling pool is sealed before and after sampling, so that the samples are prevented from being polluted and leakage is prevented.
4. The sealing mode of the sampling port designed by the invention has better universality and is suitable for various power sources.
Drawings
FIG. 1 is a schematic view showing the initial state structure of embodiment 1;
FIG. 2 is a schematic diagram of the structure at the end of sampling and release in example 1;
FIG. 3 is a schematic view showing the initial state structure of embodiment 2;
FIG. 4 is a schematic diagram of the structure at the end of sampling and release in example 2;
FIG. 5 is a schematic view showing the initial state structure of embodiment 3;
FIG. 6 is a schematic diagram of the structure at the end of sampling and release in example 3;
Fig. 7 is a schematic structural diagram of embodiment 4.
The device comprises a capsule shell, 102-medicine release holes, 103-through holes, 104-medicine bin, 105-piston, 106-first rubber plug, 107-sampling holes, 108-middle channel, 109-cylindrical connecting piece, 110-sampling pool, 111-spring, 112-waterproof cover, 113-heater, 114-fuse, 115-heating head, 116-capsule sensing and control module, 117-second rubber plug, 118-spring supporting ring, 119-medicine bin sealing plate, 120-electric control element bin, 121-piston ring, 201-line, 202-O-shaped rubber ring, 301-sampling capsule system, 302-elastic waterproof layer, 303-O-shaped piston, 304-radial through hole, 305-sampling port, 306-waterproof sleeve, 307-elastic waterproof film, 308-rubber plug and 309-circular arc piston.
Detailed Description
The invention is described in further detail below with reference to the attached drawings and specific examples:
A sampling capsule with a sampling pool sealing structure designed in embodiment 1, as shown in fig. 1 and 2, comprises a capsule shell 101, a piston 105, a spring 111, a waterproof cover 112, a heater 113, a capsule sensing and control module 116, a spring support ring 118, a sampling hole plugging member and a fusible spring fastener, wherein the outer ring of the spring support ring 118 is fixedly connected with the inner wall of the capsule shell 101 in a sealing way, the inner ring of the spring support ring 118 is fixedly connected with the opening of the waterproof cover 112 in a sealing way, the capsule shell 101 comprises an electric control element bin 120, a sampling pool 110 and a medicine bin 104 (capable of storing liquid medicine or powder medicine), the electric control element bin 120 and the sampling pool 110 are hermetically separated by the spring support ring 118 and the waterproof cover 112, the sampling pool 110 and the medicine bin 104 are hermetically separated by the piston 105, a medicine release hole 102 is formed in the capsule shell 101, the medicine release hole 102 is hermetically sealed by a sealing plug (such as a rubber plug), a through hole 103 which can be communicated with the medicine release hole 102 is formed in a medicine bin sealing plate 119 of the medicine bin 104, the through hole 103 is fixedly connected with an oil seal (such as mineral oil), the capsule sensing and control module 116 is arranged in the electric control element bin 120, the electric control element bin 120 and the sampling pool 110 are arranged in the waterproof cover 110, the piston 110 is hermetically separated by the spring support ring 110 and the piston 105, the piston 105 is hermetically separated by the piston 105, the piston 105 is hermetically and the piston 105, the piston 105 is hermetically sealed by the piston 105, and the piston 105, the piston is hermetically sealed by the medicine hole and the medicine hole 102, and the medicine hole and the medicine seal hole 116, and the medicine box is sealed by the sealing module and the medicine seal box and the sealing module. The sampling hole blocking piece can block the sampling hole 107 under the complete extension state of the spring 111, the sampling pool 110 is closed, the sampling hole 107 can be communicated with the sampling pool 110 when the piston 105 and the sampling hole blocking piece are not used for blocking the sampling hole, a communication hole which can enable the sampling pool 110 to be communicated with the medicine bin 104 is formed in the piston 105, the communication hole is blocked by the first rubber plug 106 (the first rubber plug 106 is a soft rubber plug, a needle can be inserted into the first rubber plug to be used for recovering a sample from the sampling pool 110, the soft rubber plug still blocks the sampling pool 110 when the needle is pulled out), and the heating control signal output end of the capsule sensing and controlling module 116 is connected with the control signal input end of the heater 113. The capsule sensing and control module 116 is integrated by a pH sensor, an image sensor, a microprocessor and a communication module.
In embodiment 1, there are several dry sampling holes 107, and the sampling holes 107 are all distributed on the side of the capsule housing 101.
In embodiment 1, the fusible spring fastener may be a fusible wire 114, two holes are formed in the spring supporting ring 118, the two holes are respectively blocked by two second rubber plugs 117, one end of the fusible wire 114 passes through one second rubber plug 117 and is fixedly connected with the sampling hole blocking member, and the other end of the fusible wire 114 passes through the other second rubber plug 117 and is fixedly connected with the sampling hole blocking member, and the heating head 115 of the heater 113 is in contact with the fusible wire 114. The fusible link 114 is made of a low melting point material such as nylon, a low melting point metal or a hot melt adhesive, and has a melting point of 80 to 90 ℃. The sealing device of the rubber plug is arranged at the position where the fusing easy fuse 114 penetrates through the partition plate in the capsule, and after the fusing easy fuse 114 is drawn out, the rubber plug automatically contracts, so that the sampling pool 110 is still in a sealing state.
In embodiment 1, the piston 105 is in interference fit with the inner wall of the capsule housing 101, and the piston ring 121 is in interference fit with the inner wall of the capsule housing 101. And plays a role of sealing.
The fusible spring fastener described in example 1 may also be a hot melt adhesive, with which the heating tip 115 of the heater 113 is bonded. The hot melt adhesive constrains the compressed spring, and when the hot melt adhesive is heated by the heating head 115 of the heater 113, the hot melt adhesive is fused to a specified temperature, and the spring expands.
In embodiment 1, the sampling hole blocking member is a piston ring 121, the piston ring 121 is fixedly connected with the piston 105 through a cylindrical connecting member 109, the piston ring 121 can block the sampling hole 107 in a fully extended state of the spring 111, and an intermediate channel 108 for communicating the sampling hole 107 with the sampling tank 110 is provided on a side wall of the cylindrical connecting member 109. The piston ring 121, the cylindrical connector 109, and the piston 105 may be integrally formed.
The center distance L1 of the piston 105 from the piston ring 121 is equal to the stroke L2 of the piston 105, that is, l1=l2. Preferably, L1, L2 are above 4mm, such as 4-10 mm, which design ensures that the sample cell 110 and cartridge 104 have a capacity above 0.3 mL.
In example 1, the capsule housing 101 has a length of 30mm or less and a diameter of 12mm or less.
In embodiment 1, in the initial state, the piston 105 blocks the sampling hole 107, and the sampling cell 110 is closed. The piston ring 121 is rigidly connected to the piston 105 and the intermediate channel 108 allows the aspirated sample to flow into the sampling cell 110. The spring 111 is initially in a compressed state and the fusible wire 114 restrains the spring 111. The heater 115 is in contact with the fusible yarn 114. The waterproof cover 112 separates the circuit portion of the capsule from the sampling cell 110. The capsule sensing and control module 116 includes a pH sensor, an image sensor, a microprocessor, a communication unit, and the like.
The working principle of example 1 is:
when the sensor in the capsule sensing and control module 116 determines that the capsule reaches the preset alimentary canal part, a trigger signal is sent, the heater 113 starts to work after receiving the trigger signal, and the fuse 114 is blown after the heating head 115 of the heater 113 reaches the specified temperature, so that the spring 111 is released. The spring 111 pushes the piston 105 to press the medicine compartment 104, so that the medicine is ejected from the medicine release hole 102. At the same time, the piston 105 moves away from the home position, the sampling hole 107 opens, and foreign substances are sucked into the sampling cell 110 due to the low pressure in the sampling cell 110. At the end of the piston stroke, the piston ring 121 moves to the position of the sampling bore 107 and blocks it, closing the sampling cell 110.
The solution of embodiment 1 is to ensure that the distance L1 between the piston 105 and the piston ring 121 is equal to the stroke L2 of the piston 105, i.e. l1=l2, so that embodiment 1 requires a certain spatial layout inside the capsule. However, this is more complete and, because the piston 105 is rigidly connected to the piston ring 121, it is easier to ensure resealing of the sampling port 107.
A sampling capsule having a sealing structure of a sampling pool according to embodiment 2 is basically the same as that of embodiment 1, as shown in fig. 3 and 4, except that the sampling hole blocking member is an O-shaped rubber ring 202, and the O-shaped rubber ring 202 is connected to the piston 105 through a wire 201, and the O-shaped rubber ring 202 can block the sampling hole 107 in a state that the spring 111 is fully extended.
In embodiment 2, the O-ring 202 is in an interference fit with the inner wall of the capsule housing 101.
In the initial state, the piston 105 blocks the sampling hole 107; when the sensor in the capsule sensing and control module 116 determines that the capsule reaches the preset alimentary canal part, a trigger signal is sent, the heater 113 starts to work after receiving the trigger signal, and the fuse 114 is blown after the heating head 115 of the heater 113 reaches the specified temperature, so that the spring 111 is released. The spring 111 pushes the piston 105 to press the medicine compartment 104, so that the medicine is ejected from the medicine release hole 102. At the same time, the piston 105 is moved away from the home position, the sampling hole 107 is opened, sampling is started, the piston 105 moves rightward, the sampling hole 107 is released, and the wire 201 is pulled; after sampling is completed, the piston 105 pulls the O-ring 202 to the sampling hole 107 via the wire 201 to close it. In accordance with the principles described above, the length of the wire 201 is equal to the stroke of the piston 105.
The solution of embodiment 2 uses the wire 201 to connect the piston 105 and the rubber ring 202 instead of rigid connection, which reduces the limitation on the internal space layout of the capsule and makes the size design more flexible. However, a non-rigid connection places greater demands on the accuracy of the installation, piston 105 travel.
In the sampling capsule system designed in embodiment 3, as shown in fig. 5 and 6, a sampling capsule system 301 comprises a capsule housing 101, a spring 111, a waterproof sleeve 306, a circular arc piston 309, a heater 113, a capsule sensing and control module 116, a spring support ring 118, an O-shaped piston 303, an elastic waterproof layer 302 and a fusible spring fastener, wherein an outer ring of the spring support ring 118 is fixedly connected with an inner wall of the capsule housing 101 in a sealing manner, an inner ring of the spring support ring 118 is fixedly connected with an opening of the waterproof sleeve 306 in a sealing manner, wherein the capsule housing 101 comprises an electric control element bin 120, a sampling pool 110 and a medicine bin 104, the electric control element bin 120 is hermetically separated from the sampling pool 110 by the spring support ring 118 and the waterproof sleeve 306, the sampling pool 110 is separated from the medicine bin 104 by the circular arc piston 309, an elastic waterproof film 307 is arranged between the capsule housing 101 and the circular arc piston 309, the O-shaped piston 303 is fixedly connected with an opening end of the circular arc piston 309, the capsule shell 101, the circular arc piston 309 and the elastic waterproof membrane 307 enclose the drug delivery hole 102 on the capsule shell 101, the drug delivery hole 102 is sealed by a sealing plug, the circular arc piston 309 is provided with a communication hole opposite to the drug delivery hole 102, the communication hole is blocked by a rubber plug 308 (the rubber plug 308 can be inserted into a needle for recovering a sample from a sampling tank, the rubber plug 308 still seals the sampling tank when the needle is pulled out), the capsule sensing and control module 116 is arranged in the electric control element bin 120, the heater 113 is arranged in the waterproof sleeve 306, the spring 111 is arranged between the spring support ring 118 and the O-shaped piston 303, one end of the spring 111 is fixedly connected with the spring support ring 118, the other end of the spring 111 is connected with the O-shaped piston 303, the spring 111 is sleeved outside the waterproof sleeve 306, one end of the elastic waterproof layer 302 is fixedly connected with the spring support ring 118, the other end of the elastic waterproof layer 302 is connected with the O-shaped piston 303, the elastic waterproof layer 302 is attached to the outer ring surface of the spring 111, the sampling pool 110 is surrounded by the circular arc-shaped piston 309, the waterproof sleeve 306 and the elastic waterproof layer 302, the spring 111 is limited in a compressed state by a fusible spring fastener, the heating head 115 of the heater 113 can heat the fusible spring fastener to enable the fusible spring fastener to release the fastening of the spring 111 in the compressed state, the O-shaped piston 303 is provided with a radial through hole 304, the capsule shell 101 is provided with a sampling port 305, the radial through hole 304 of the O-shaped piston 303 is blocked by the inner wall of the capsule shell 101 in the compressed state of the spring 111, the radial through hole 304 can be communicated with the sampling port 305 after the spring 111 is completely stretched, the radial through hole 304 is blocked again by the inner wall of the capsule shell 101, and the heating control signal output end of the capsule sensing and control module 116 is connected with the control signal input end of the heater 113.
In embodiment 3, the fusible spring fastener is a fusible wire 114, two holes are formed in the spring supporting ring 118, the two holes are respectively blocked by two second rubber plugs 117, one end of the fusible wire 114 passes through one second rubber plug 117 and is fixedly connected with the O-shaped piston 303, and the other end of the fusible wire 114 passes through the other second rubber plug 117 and is fixedly connected with the O-shaped piston 303, and the heating head 115 of the heater 113 is in contact with the fusible wire 114.
In embodiment 3, when the sensor in the capsule sensing and control module 116 determines that the capsule reaches the preset alimentary canal part, a trigger signal is sent, the heater 113 starts to work after receiving the trigger signal, the heating head 115 of the heater 113 melts the fuse 114 after reaching the specified temperature, the spring 111 pushes the circular arc-shaped piston 309 to move rightwards, the medicine is ejected from the medicine release hole 102, the radial through hole 304 is aligned with the sampling port 305, and the foreign substances are inhaled due to the low pressure in the sampling pool. At the end of the travel of the circular arc piston 309 and the O-piston 303, the radial through-holes 304 are again offset from the sampling ports 305, and the sampling cells are closed.
The solution of embodiment 3 uses the way of forming radial through holes 304 on the O-shaped piston 303 and matching with the sampling port 305 on the capsule housing 101 to sample, and the way of connecting the two pistons as in embodiments 1 and 2 is omitted. Therefore, the space layout limitation, the installation and the piston stroke precision are slightly lower. However, this design places greater demands on materials such as the elastic waterproof layer 302 and the elastic waterproof membrane 307.
A sampling capsule with a sealing structure of a sampling pool according to embodiment 4 is basically the same as that of embodiment 2, as shown in fig. 7, except that the piston 105 is an arc-shaped piston matched with the end of the capsule housing 101, the end of the arc-shaped piston is provided with a spring support table 4, and the other end of the spring 111 is connected with the spring support table 4 of the piston 105. The arc-shaped piston is in interference fit with the inner wall of the capsule housing 101.
What is not described in detail in this specification is prior art known to those skilled in the art.
Claims (10)
1. A sampling capsule having a sampling cell sealing structure, characterized in that: the capsule comprises a capsule shell (101), a piston (105), a spring (111), a waterproof cover (112), a heater (113), a capsule sensing and control module (116), a spring support ring (118), a sampling hole plugging piece and a fusible spring fastener, wherein the outer ring of the spring support ring (118) is fixedly connected with the inner wall of the capsule shell (101) in a sealing way, the inner ring of the spring support ring (118) is fixedly connected with the opening part of the waterproof cover (112) in a sealing way, the capsule shell (101) comprises an electric control element bin (120), a sampling pool (110) and a medicine bin (104), the electric control element bin (120) and the sampling pool (110) are separated by the spring support ring (118) and the waterproof cover (112) in a sealing way, a medicine release hole (102) is formed in the capsule shell (101) in a sealing way, a medicine bin sealing plate (119) of the medicine bin (104) is provided with a through hole (103) which can be communicated with the medicine release hole (102) in a sealing way, the through hole (103) adopts an oil seal, the capsule sensing and control module (116) is arranged in the electric control element (110) in the waterproof cover (110) and in the sampling pool (110) and the heating pool (110) is arranged in the electric control element (112), one end of the spring (111) is connected with the spring support ring (118), the piston (105) is connected to the other end of the spring (111), the spring (111) is limited in the compression state by fusible spring fastening piece, the heating head (115) of the heater (113) can heat the fusible spring fastening piece, the fastening of the compression state of the spring (111) can be relieved by the fusible spring fastening piece, a sampling hole plugging piece is arranged on the piston (105), a sampling hole (107) is arranged on the capsule shell (101), the piston (105) can plug the sampling hole (107) in the compression state of the spring (111), the sampling hole plugging piece can plug the sampling hole (107) in the complete extension state of the spring (111), the sampling hole (107) can be communicated with the sampling pool (110) when the piston (105) and the sampling hole plugging piece are not plugged, a communication hole capable of enabling the sampling pool (110) to be communicated with the medicine bin (104) is formed in the piston (105), the communication hole is plugged by the first rubber plug (106), and a heating control signal output end of the capsule sensing and control module (116) is connected with a control signal input end of the heater (113).
2. The sampling capsule with a sampling cell sealing structure of claim 1, wherein: the fusible spring fastener is a fusible wire (114), two holes are formed in the spring supporting ring (118), the two holes are respectively blocked by two second rubber plugs (117), one end of the fusible wire (114) penetrates through one second rubber plug (117) and then is fixedly connected with the sampling hole blocking piece, the other end of the fusible wire (114) penetrates through the other second rubber plug (117) and then is fixedly connected with the sampling hole blocking piece, and a heating head (115) of a heater (113) is in contact with the fusible wire (114).
3. The sampling capsule with a sampling cell sealing structure of claim 1, wherein: the fusible spring fastener is hot melt adhesive, and a heating head (115) of the heater (113) is contacted with the hot melt adhesive.
4. A sampling capsule having a sampling cell sealing structure according to claim 1 or 2 or 3, characterized in that: the sampling hole plugging piece is a piston ring (121), the piston ring (121) is fixedly connected with the piston (105) through a cylindrical connecting piece (109), the piston ring (121) can plug the sampling hole (107) under the complete extension state of the spring (111), and a middle channel (108) used for communicating the sampling hole (107) and the sampling pool (110) is arranged on the side wall of the cylindrical connecting piece (109).
5. The sampling capsule with a sampling cell sealing structure of claim 1, wherein: the sampling hole plugging piece is an O-shaped rubber ring (202), the O-shaped rubber ring (202) is connected with the piston (105) through a wire (201), and the O-shaped rubber ring (202) can plug the sampling hole (107) under the condition that the spring (111) is fully extended.
6. The sampling capsule with a sampling cell sealing structure of claim 5, wherein: the piston (105) is an arc-shaped piston matched with the end part of the capsule shell (101), a spring supporting table (4) is arranged at the end part of the arc-shaped piston, and the other end of the spring (111) is connected with the spring supporting table (4) of the piston (105).
7. The sampling capsule with a sampling cell sealing structure of claim 4, wherein: the piston (105) is in interference fit with the inner wall of the capsule shell (101), and the piston ring (121) is in interference fit with the inner wall of the capsule shell (101).
8. The sampling capsule with a sampling cell sealing structure of claim 5, wherein: the O-shaped rubber ring (202) is in interference fit with the inner wall of the capsule shell (101).
9. A sampling capsule system, characterized by: the sampling capsule system (301) comprises a capsule shell (101), a spring (111), a waterproof sleeve (306), a circular arc-shaped piston (309), a heater (113), a capsule sensing and control module (116), a spring support ring (118), an O-shaped piston (303), an elastic waterproof layer (302) and a fusible spring fastener, wherein the outer ring of the spring support ring (118) is fixedly connected with the inner wall of the capsule shell (101) in a sealing way, the inner ring of the spring support ring (118) is fixedly connected with the opening part of the waterproof sleeve (306) in a sealing way, the capsule shell (101) comprises an electric control element bin (120), a sampling pool (110) and a medicine bin (104), the electric control element bin (120) is sealed by the spring support ring (118) and the waterproof sleeve (306), the sampling pool (110) is separated from the medicine bin (104) by the circular arc-shaped piston (309), an elastic waterproof film (307) is arranged between the capsule shell (101) and the circular arc-shaped piston (309), the O-shaped piston (303) is fixedly connected with the opening end of the circular arc-shaped piston (309), the capsule shell (101), the circular arc-shaped piston (309) and the elastic film (307) are sealed by the sealing plug (104), the medicine bin (102) is sealed by the sealing hole, the circular arc piston (309) is provided with a communication hole opposite to the drug release hole (102), the communication hole is blocked by a rubber plug (308), the capsule sensing and control module (116) is arranged in the electric control element bin (120), the heater (113) is arranged in the waterproof sleeve (306), the spring (111) is arranged between the spring support ring (118) and the O-shaped piston (303), one end of the spring (111) is fixedly connected with the spring support ring (118), the other end of the spring (111) is connected with the O-shaped piston (303), the spring (111) is sleeved outside the waterproof sleeve (306), one end of the elastic waterproof layer (302) is fixedly connected with the spring support ring (118), the other end of the elastic waterproof layer (302) is connected with the O-shaped piston (303), the elastic waterproof layer (302) is attached to the outer ring surface of the spring (111), the sampling pool (110) is surrounded by the circular arc piston (309), the waterproof sleeve (306) and the elastic waterproof layer (302), the spring (111) is limited in a compressed state by a fusible spring fastener, the heating head (115) of the heater (113) can be fixedly connected with the spring support ring (118), the fusible spring fastener, the fusible piston (101) can be fastened, the radial piston (305) can be fastened, the piston (101) can be fastened, the radial direction of the piston (101) can be fastened by the fusible piston (101) can be fastened, the radial through hole (304) of the O-shaped piston (303) is blocked by the inner wall of the capsule shell (101) when the spring (111) is in a compressed state, the radial through hole (304) can be communicated with the sampling port (305) after the spring (111) is decompressed, the radial through hole (304) is blocked again by the inner wall of the capsule shell (101) after the spring (111) is fully extended, and the heating control signal output end of the capsule sensing and control module (116) is connected with the control signal input end of the heater (113).
10. The sampling capsule system of claim 9, wherein: the fusible spring fastener is a fusible wire (114), two holes are formed in the spring supporting ring (118), the two holes are respectively blocked by two second rubber plugs (117), one end of the fusible wire (114) penetrates through one second rubber plug (117) and then is fixedly connected with the O-shaped piston (303), the other end of the fusible wire (114) penetrates through the other second rubber plug (117) and then is fixedly connected with the O-shaped piston (303), and a heating head (115) of the heater (113) is in contact with the fusible wire (114).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810617882.4A CN108836237B (en) | 2018-06-15 | 2018-06-15 | Sampling capsule with sampling pool sealing structure |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810617882.4A CN108836237B (en) | 2018-06-15 | 2018-06-15 | Sampling capsule with sampling pool sealing structure |
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| CN108836237A CN108836237A (en) | 2018-11-20 |
| CN108836237B true CN108836237B (en) | 2024-05-10 |
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Families Citing this family (10)
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|---|---|---|---|---|
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| AU2018269556B2 (en) | 2017-05-17 | 2024-01-25 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| WO2020157324A1 (en) * | 2019-02-01 | 2020-08-06 | Novo Nordisk A/S | Medical device with actuation mechanism |
| WO2021017791A1 (en) * | 2019-07-26 | 2021-02-04 | 温州芳植生物科技有限公司 | Gastrointestinal tract sampling and drug releasing capsule |
| CN116096452A (en) * | 2020-08-10 | 2023-05-09 | 麻省理工学院 | Drug delivery device |
| CN111973136B (en) * | 2020-09-14 | 2022-11-25 | 上海安翰医疗技术有限公司 | Control method and control system of magnetic control capsule endoscope device |
| EP4221787A1 (en) * | 2020-09-30 | 2023-08-09 | Novo Nordisk A/S | A swallowable capsule device |
| CN113769250B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0430535U (en) * | 1990-07-06 | 1992-03-11 | ||
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN1820798A (en) * | 2006-01-28 | 2006-08-23 | 重庆大学 | Capsule type digestive tract medicine releasing and sampling device |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| WO2018050647A1 (en) * | 2016-09-15 | 2018-03-22 | Stoco 10 GmbH | Fluid sampling device |
| CN209153588U (en) * | 2018-06-15 | 2019-07-26 | 安翰科技(武汉)股份有限公司 | A kind of sampling capsule with sampling pool sealing structure and a kind of sampling capsule system |
-
2018
- 2018-06-15 CN CN201810617882.4A patent/CN108836237B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0430535U (en) * | 1990-07-06 | 1992-03-11 | ||
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN1820798A (en) * | 2006-01-28 | 2006-08-23 | 重庆大学 | Capsule type digestive tract medicine releasing and sampling device |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| WO2018050647A1 (en) * | 2016-09-15 | 2018-03-22 | Stoco 10 GmbH | Fluid sampling device |
| CN209153588U (en) * | 2018-06-15 | 2019-07-26 | 安翰科技(武汉)股份有限公司 | A kind of sampling capsule with sampling pool sealing structure and a kind of sampling capsule system |
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| CN108836237A (en) | 2018-11-20 |
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