CN108830282A - A kind of the breast lump information extraction and classification method of breast X-ray image - Google Patents

A kind of the breast lump information extraction and classification method of breast X-ray image Download PDF

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CN108830282A
CN108830282A CN201810530455.2A CN201810530455A CN108830282A CN 108830282 A CN108830282 A CN 108830282A CN 201810530455 A CN201810530455 A CN 201810530455A CN 108830282 A CN108830282 A CN 108830282A
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breast
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lump
ray image
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高婧婧
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University of Electronic Science and Technology of China
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/24Classification techniques
    • G06F18/243Classification techniques relating to the number of classes
    • G06F18/2431Multiple classes
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/048Activation functions
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/40Extraction of image or video features
    • G06V10/44Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03Recognition of patterns in medical or anatomical images
    • G06V2201/032Recognition of patterns in medical or anatomical images of protuberances, polyps nodules, etc.

Abstract

The invention discloses a kind of breast lump information extraction of breast X-ray image and classification methods, include the following steps:S1, breast X-ray image is inputted into four parallel-convolution neural networks;S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains the classification information of breast lump.The breast lump information extraction and classification method of breast X-ray image provided by the invention, the redundancy feature of convolutional neural networks extraction can be effectively removed, four classification tasks can to tangle mutually by multi-tag multitask network to constrain and mutually promote, clear breast lump classification information is provided for doctor, the auxiliary diagnosis of breast lump related disease is provided.

Description

A kind of the breast lump information extraction and classification method of breast X-ray image
Technical field
The invention belongs to breast X-ray technical field of image processing, and in particular to a kind of breast lump letter of breast X-ray image Breath extracts and classification method.
Background technique
Breast cancer is one of the most common malignant tumors in women, shows just to have a women in every two minutes according to related data It is diagnosed with breast cancer.In China, breast cancer is averagely every 12 minutes the main reason for leading to 40~50 years old women die Just there is a women to die of breast cancer;In Urban Women, every about just thering are 3~4 people to suffer from breast cancer in 10,000 people, not only such as This, the disease incidence of breast cancer is just steeply risen with annual 3%~4% speed.Therefore, early detection, early diagnosis and early stage Treatment is acknowledged as the effective measures of control breast cancer development, and has to the survival rate and quality of life that improve patient important Meaning, wherein early detection top the list the position wanted.
Breast lump is the sings and symptoms that breast cancer must have, and generally individually, form is indefinite, and matter is harder tough.In recent years, In order to improve the diagnosis efficiency of breast cancer, breast lump develops towards intelligent direction always in early stage research, with present It continues to develop scientific and technically, artificial intelligence technology is constantly progressive, and artificial neural network technology is also increasingly mature, its classification energy Power is also increasingly stronger, and has intelligence, provides a kind of new method for tumor of breast identification.
Convolutional neural networks (Convolutional Neural Network, CNN) are a kind of feedforward neural networks, it Artificial neuron can respond the surrounding cells in a part of coverage area, have outstanding performance for large-scale image procossing;It is wrapped Include convolutional layer (convolutional layer) and pond layer (pooling layer).
At present in medical image analysis field, convolutional neural networks are mainly used for the realization of single learning tasks.Such as it is right Simple lump information extraction in breast X-ray image carries out simple benign from malignant tumors judgement, is difficult the medical diagnosis with doctor Authority combines, it is difficult to relatively reliable data foundation is provided during the diagnosis of doctor.
Summary of the invention
For above-mentioned deficiency in the prior art, the breast lump information extraction of breast X-ray image provided by the invention and Classification method solves when being analyzed in the prior art using convolutional neural networks breast X-ray image, can only carry out simple The good pernicious information extraction of lump, it is difficult to for doctor provide accurately diagnosis authority the problem of.
In order to achieve the above object of the invention, the technical solution adopted by the present invention is:
A kind of the breast lump information extraction and classification method of breast X-ray image, include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains breast lump Classification information.
Further, in the step S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full connection Layer;Network-order is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described The size of full articulamentum is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, by each convolutional Neural net 192 character representations that network extracts are one group of high-level semantics features vector, respectively X1,X2,X3And X4
Further, the building method of the multi-tag multitask network is specially:
By high-level semantics features vector X described in 4 groups1,X2,X3And X4, respectively as in multi-tag multi-task learning for obtaining Must classify discreet value 4 excitation functions input value, the relationship between discreet value and physical tags that will classify is as multi-tag The objective function of multi-task learning carries out objective function to the objective function minimizing, and using stochastic gradient descent method Network training obtains the value and deviant of all kernel functions of multi-tag multitask network, realizes multi-tag multitask network Build;
The excitation function is softmax function or ReLU function.
Further, in the step S3:
Classification task in multi-tag multitask network includes the classification task of breast lump shape, breast lump edge The classification task of classification task, the classification task of breast lump BI-BADS classification and Diagnosis of Breast tumors;
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
It further, include total losses function L (W, b) and j-th in the objective function of the multi-tag multitask network The loss function L of taskI, j(W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task, λjFor the loss weight of the loss function of j-th of task, wherein j =1,2,3,4;Respectively lump Shape Classification task, mass edge classification task, lump BI-BADS classify task and swollen The good pernicious classification task of block;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of sample;
Indicate the output for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks Value;
CjIndicate the number of tags of j-th of task.
Further, in the total losses function L, the loss weight λ of the loss function of j-th of taskjRespectivelyWith 1;
The loss function L of j-th of taskI, jIn, the number of tags C of j-th of taskjRespectively 14,18,7,3.
Beneficial effects of the present invention are:The breast lump information extraction of breast X-ray image provided by the invention and classification side Method can effectively remove the redundancy feature of convolutional neural networks extraction, can make four points by multi-tag multitask network Generic task, which tangles mutually, to constrain and mutually promotes, and provides clear breast lump classification information for doctor, provides breast lump phase The auxiliary diagnosis of related disorders.
Detailed description of the invention
Fig. 1 is that the breast lump information extraction of breast X-ray image and classification method are realized in embodiment provided by the invention Flow chart.
Specific embodiment
A specific embodiment of the invention is described below, in order to facilitate understanding by those skilled in the art this hair It is bright, it should be apparent that the present invention is not limited to the ranges of specific embodiment, for those skilled in the art, As long as various change is in the spirit and scope of the present invention that the attached claims limit and determine, these variations are aobvious and easy See, all are using the innovation and creation of present inventive concept in the column of protection.
As shown in Figure 1, the breast lump information extraction and classification method of a kind of breast X-ray image, include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
In above-mentioned steps S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full connection Layer;Network-order is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described The size of full articulamentum is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, by each convolutional Neural net 192 character representations that network extracts are one group of high-level semantics features vector, respectively X1,X2,X3And X4
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains breast lump Classification information.
The building method of above-mentioned multi-tag multitask network is specially:
Swash high-level semantics features described in 4 groups as 4 for being used to obtain classification discreet value in multi-tag multi-task learning The input value for encouraging function, the relationship between discreet value and physical tags that will classify is as the target letter of multi-tag multi-task learning Number carries out network training to objective function to the objective function minimizing, and using stochastic gradient descent method, obtains multi-tag The value and deviant of all kernel functions of multitask network realize building for multi-tag multitask network;Excitation function is Softmax function or ReLU function.
Classification task in above-mentioned multi-tag multitask network includes the classification task of breast lump shape, breast lump side Classification task, the classification task of breast lump BI-BADS classification and the classification task of Diagnosis of Breast tumors of edge;Four component The input of excitation function in generic task respectively corresponds 4 groups of high-level semantics features vectors X1, X2, X3 of convolutional neural networks extraction And X4, i.e. the high-level semantics features that the different training objective of four classes causes each convolutional neural networks to extract are that have significant difference 's.
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
The objective function of the network of multi-tag multitask include total losses function L (W, b) be and j-th of task loss Function LI, j(W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task;
λjFor the loss weight of the loss function of j-th of task, wherein j=1,2,3,4;Respectively lump Shape Classification Task, mass edge classification task, lump BI-BADS classification task and the good pernicious classification task of lump;Lose weight λj RespectivelyWith 1;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of training sample;
Indicate the output for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks Value;
CjFor the number of tags of j-th of task, respectively 14,18,7,3.
In one embodiment of the invention, in the build process of above-mentioned multi-tag multitask network, boarding steps are utilized Spending the process that descent method carries out network training to objective function is specially:
Total losses function L (W, b) is sought respectively be about the gradient of kernel function value WThe gradient of deviant b For
According to the gradient of W, the iteration more new formula for obtaining W is:
The iteration of b more new formula is:
In formula, ρ is step-length, may be configured as the arbitrary value between 0-0.1;
Update is iterated to W and b respectively using formula (3) and formula (4), when reaching pre-set decision condition When, iteration stopping completes multi-tag multitask network to obtain all kernel function value W and deviant b of multi-tag multitask Build.Stochastic gradient descent training is to carry out gradient calculating with identical sample, therefore the speed of network training is non-every time It is often fast.
The breast lump information extraction and classification method of breast X-ray image provided by the invention, can effectively remove convolution The redundancy feature that neural network is extracted can make four classification tasks tangle constraint mutually simultaneously by multi-tag multitask network It mutually promotes, provides clear breast lump classification information for doctor, the auxiliary diagnosis of breast lump related disease is provided.

Claims (6)

1. the breast lump information extraction and classification method of a kind of breast X-ray image, which is characterized in that include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains the classification of breast lump Information.
2. the breast lump information extraction and classification method of breast X-ray image according to claim 1, which is characterized in that In the step S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full articulamentum;Net Network sequence is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described to connect entirely The size for connecing layer is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, and each convolutional neural networks are mentioned 192 character representations taken are one group of high-level semantics features vector, respectively X1,X2,X3And X4
3. the breast lump information extraction and classification method of breast X-ray image according to claim 2, which is characterized in that The building method of the multi-tag multitask network is specially:
By high-level semantics features vector X described in 4 groups1,X2,X3And X4, respectively as in multi-tag multi-task learning for being divided The input value of 4 excitation functions of class discreet value, the relationship between discreet value and physical tags that will classify is as multi-tag more The objective function of business study carries out network to objective function to the objective function minimizing, and using stochastic gradient descent method Training obtains the value and deviant of all kernel functions of multi-tag multitask network, realizes taking for multi-tag multitask network It builds;
The excitation function is softmax function or ReLU function.
4. the breast lump information extraction and classification method of breast X-ray image according to claim 3, which is characterized in that In the step S3:
Classification task in multi-tag multitask network includes the classification of the classification task of breast lump shape, breast lump edge The classification task of task, the classification task of breast lump BI-BADS classification and Diagnosis of Breast tumors;
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
5. the breast lump information extraction and classification method of breast X-ray image according to claim 3, which is characterized in that In the loss function L that the objective function of the multi-tag multitask network includes total losses function L (W, b) and j-th of taskI, j (W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task, λjFor the loss weight of the loss function of j-th of task, wherein j=1, 2,3,4;Respectively lump Shape Classification task, mass edge classification task, lump BI-BADS classification task and lump are good Pernicious classification task;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of sample;
xykIndicate the output valve for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks;
CjIndicate the number of tags of j-th of task.
6. the breast lump information extraction and classification method of breast X-ray image according to claim 5, which is characterized in that In the total losses function L, the loss weight λ of the loss function of j-th of taskjRespectivelyWith 1;
The loss function L of j-th of taskI, jIn, the number of tags C of j-th of taskjRespectively 14,18,7,3.
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CN110827296A (en) * 2019-11-01 2020-02-21 南京信息工程大学 Mammary gland X-ray image analysis method of multi-target integrated deep neural network
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CN111709950A (en) * 2020-08-20 2020-09-25 成都金盘电子科大多媒体技术有限公司 Mammary gland molybdenum target AI auxiliary screening method
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Application publication date: 20181116