CN108830282A - A kind of the breast lump information extraction and classification method of breast X-ray image - Google Patents
A kind of the breast lump information extraction and classification method of breast X-ray image Download PDFInfo
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- G06V2201/03—Recognition of patterns in medical or anatomical images
- G06V2201/032—Recognition of patterns in medical or anatomical images of protuberances, polyps nodules, etc.
Abstract
The invention discloses a kind of breast lump information extraction of breast X-ray image and classification methods, include the following steps:S1, breast X-ray image is inputted into four parallel-convolution neural networks;S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains the classification information of breast lump.The breast lump information extraction and classification method of breast X-ray image provided by the invention, the redundancy feature of convolutional neural networks extraction can be effectively removed, four classification tasks can to tangle mutually by multi-tag multitask network to constrain and mutually promote, clear breast lump classification information is provided for doctor, the auxiliary diagnosis of breast lump related disease is provided.
Description
Technical field
The invention belongs to breast X-ray technical field of image processing, and in particular to a kind of breast lump letter of breast X-ray image
Breath extracts and classification method.
Background technique
Breast cancer is one of the most common malignant tumors in women, shows just to have a women in every two minutes according to related data
It is diagnosed with breast cancer.In China, breast cancer is averagely every 12 minutes the main reason for leading to 40~50 years old women die
Just there is a women to die of breast cancer;In Urban Women, every about just thering are 3~4 people to suffer from breast cancer in 10,000 people, not only such as
This, the disease incidence of breast cancer is just steeply risen with annual 3%~4% speed.Therefore, early detection, early diagnosis and early stage
Treatment is acknowledged as the effective measures of control breast cancer development, and has to the survival rate and quality of life that improve patient important
Meaning, wherein early detection top the list the position wanted.
Breast lump is the sings and symptoms that breast cancer must have, and generally individually, form is indefinite, and matter is harder tough.In recent years,
In order to improve the diagnosis efficiency of breast cancer, breast lump develops towards intelligent direction always in early stage research, with present
It continues to develop scientific and technically, artificial intelligence technology is constantly progressive, and artificial neural network technology is also increasingly mature, its classification energy
Power is also increasingly stronger, and has intelligence, provides a kind of new method for tumor of breast identification.
Convolutional neural networks (Convolutional Neural Network, CNN) are a kind of feedforward neural networks, it
Artificial neuron can respond the surrounding cells in a part of coverage area, have outstanding performance for large-scale image procossing;It is wrapped
Include convolutional layer (convolutional layer) and pond layer (pooling layer).
At present in medical image analysis field, convolutional neural networks are mainly used for the realization of single learning tasks.Such as it is right
Simple lump information extraction in breast X-ray image carries out simple benign from malignant tumors judgement, is difficult the medical diagnosis with doctor
Authority combines, it is difficult to relatively reliable data foundation is provided during the diagnosis of doctor.
Summary of the invention
For above-mentioned deficiency in the prior art, the breast lump information extraction of breast X-ray image provided by the invention and
Classification method solves when being analyzed in the prior art using convolutional neural networks breast X-ray image, can only carry out simple
The good pernicious information extraction of lump, it is difficult to for doctor provide accurately diagnosis authority the problem of.
In order to achieve the above object of the invention, the technical solution adopted by the present invention is:
A kind of the breast lump information extraction and classification method of breast X-ray image, include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains breast lump
Classification information.
Further, in the step S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full connection
Layer;Network-order is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described
The size of full articulamentum is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, by each convolutional Neural net
192 character representations that network extracts are one group of high-level semantics features vector, respectively X1,X2,X3And X4。
Further, the building method of the multi-tag multitask network is specially:
By high-level semantics features vector X described in 4 groups1,X2,X3And X4, respectively as in multi-tag multi-task learning for obtaining
Must classify discreet value 4 excitation functions input value, the relationship between discreet value and physical tags that will classify is as multi-tag
The objective function of multi-task learning carries out objective function to the objective function minimizing, and using stochastic gradient descent method
Network training obtains the value and deviant of all kernel functions of multi-tag multitask network, realizes multi-tag multitask network
Build;
The excitation function is softmax function or ReLU function.
Further, in the step S3:
Classification task in multi-tag multitask network includes the classification task of breast lump shape, breast lump edge
The classification task of classification task, the classification task of breast lump BI-BADS classification and Diagnosis of Breast tumors;
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
It further, include total losses function L (W, b) and j-th in the objective function of the multi-tag multitask network
The loss function L of taskI, j(W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task, λjFor the loss weight of the loss function of j-th of task, wherein j
=1,2,3,4;Respectively lump Shape Classification task, mass edge classification task, lump BI-BADS classify task and swollen
The good pernicious classification task of block;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of sample;
Indicate the output for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks
Value;
CjIndicate the number of tags of j-th of task.
Further, in the total losses function L, the loss weight λ of the loss function of j-th of taskjRespectivelyWith 1;
The loss function L of j-th of taskI, jIn, the number of tags C of j-th of taskjRespectively 14,18,7,3.
Beneficial effects of the present invention are:The breast lump information extraction of breast X-ray image provided by the invention and classification side
Method can effectively remove the redundancy feature of convolutional neural networks extraction, can make four points by multi-tag multitask network
Generic task, which tangles mutually, to constrain and mutually promotes, and provides clear breast lump classification information for doctor, provides breast lump phase
The auxiliary diagnosis of related disorders.
Detailed description of the invention
Fig. 1 is that the breast lump information extraction of breast X-ray image and classification method are realized in embodiment provided by the invention
Flow chart.
Specific embodiment
A specific embodiment of the invention is described below, in order to facilitate understanding by those skilled in the art this hair
It is bright, it should be apparent that the present invention is not limited to the ranges of specific embodiment, for those skilled in the art,
As long as various change is in the spirit and scope of the present invention that the attached claims limit and determine, these variations are aobvious and easy
See, all are using the innovation and creation of present inventive concept in the column of protection.
As shown in Figure 1, the breast lump information extraction and classification method of a kind of breast X-ray image, include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
In above-mentioned steps S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full connection
Layer;Network-order is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described
The size of full articulamentum is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, by each convolutional Neural net
192 character representations that network extracts are one group of high-level semantics features vector, respectively X1,X2,X3And X4。
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains breast lump
Classification information.
The building method of above-mentioned multi-tag multitask network is specially:
Swash high-level semantics features described in 4 groups as 4 for being used to obtain classification discreet value in multi-tag multi-task learning
The input value for encouraging function, the relationship between discreet value and physical tags that will classify is as the target letter of multi-tag multi-task learning
Number carries out network training to objective function to the objective function minimizing, and using stochastic gradient descent method, obtains multi-tag
The value and deviant of all kernel functions of multitask network realize building for multi-tag multitask network;Excitation function is
Softmax function or ReLU function.
Classification task in above-mentioned multi-tag multitask network includes the classification task of breast lump shape, breast lump side
Classification task, the classification task of breast lump BI-BADS classification and the classification task of Diagnosis of Breast tumors of edge;Four component
The input of excitation function in generic task respectively corresponds 4 groups of high-level semantics features vectors X1, X2, X3 of convolutional neural networks extraction
And X4, i.e. the high-level semantics features that the different training objective of four classes causes each convolutional neural networks to extract are that have significant difference
's.
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
The objective function of the network of multi-tag multitask include total losses function L (W, b) be and j-th of task loss
Function LI, j(W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task;
λjFor the loss weight of the loss function of j-th of task, wherein j=1,2,3,4;Respectively lump Shape Classification
Task, mass edge classification task, lump BI-BADS classification task and the good pernicious classification task of lump;Lose weight λj
RespectivelyWith 1;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of training sample;
Indicate the output for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks
Value;
CjFor the number of tags of j-th of task, respectively 14,18,7,3.
In one embodiment of the invention, in the build process of above-mentioned multi-tag multitask network, boarding steps are utilized
Spending the process that descent method carries out network training to objective function is specially:
Total losses function L (W, b) is sought respectively be about the gradient of kernel function value WThe gradient of deviant b
For
According to the gradient of W, the iteration more new formula for obtaining W is:
The iteration of b more new formula is:
In formula, ρ is step-length, may be configured as the arbitrary value between 0-0.1;
Update is iterated to W and b respectively using formula (3) and formula (4), when reaching pre-set decision condition
When, iteration stopping completes multi-tag multitask network to obtain all kernel function value W and deviant b of multi-tag multitask
Build.Stochastic gradient descent training is to carry out gradient calculating with identical sample, therefore the speed of network training is non-every time
It is often fast.
The breast lump information extraction and classification method of breast X-ray image provided by the invention, can effectively remove convolution
The redundancy feature that neural network is extracted can make four classification tasks tangle constraint mutually simultaneously by multi-tag multitask network
It mutually promotes, provides clear breast lump classification information for doctor, the auxiliary diagnosis of breast lump related disease is provided.
Claims (6)
1. the breast lump information extraction and classification method of a kind of breast X-ray image, which is characterized in that include the following steps:
S1, breast X-ray image is inputted into four parallel-convolution neural networks;
S2, the high-level semantics features that breast X-ray image is extracted based on four parallel-convolution neural networks;
S3, multi-tag multi-task learning network training is carried out to the high-level semantics features of extraction, and obtains the classification of breast lump
Information.
2. the breast lump information extraction and classification method of breast X-ray image according to claim 1, which is characterized in that
In the step S2:
Each parallel-convolution neural network includes two convolutional layers, two maximum pond layers and a full articulamentum;Net
Network sequence is to be followed successively by convolutional layer, pond layer, convolutional layer, pond layer and full articulamentum;
Each convolutional layer includes 65 × 5 convolution kernels, and each pond layer includes 12 × 2 core, described to connect entirely
The size for connecing layer is 192 × 1;
Each convolutional neural networks extract the feature of 192 breast X-ray images, and each convolutional neural networks are mentioned
192 character representations taken are one group of high-level semantics features vector, respectively X1,X2,X3And X4。
3. the breast lump information extraction and classification method of breast X-ray image according to claim 2, which is characterized in that
The building method of the multi-tag multitask network is specially:
By high-level semantics features vector X described in 4 groups1,X2,X3And X4, respectively as in multi-tag multi-task learning for being divided
The input value of 4 excitation functions of class discreet value, the relationship between discreet value and physical tags that will classify is as multi-tag more
The objective function of business study carries out network to objective function to the objective function minimizing, and using stochastic gradient descent method
Training obtains the value and deviant of all kernel functions of multi-tag multitask network, realizes taking for multi-tag multitask network
It builds;
The excitation function is softmax function or ReLU function.
4. the breast lump information extraction and classification method of breast X-ray image according to claim 3, which is characterized in that
In the step S3:
Classification task in multi-tag multitask network includes the classification of the classification task of breast lump shape, breast lump edge
The classification task of task, the classification task of breast lump BI-BADS classification and Diagnosis of Breast tumors;
In the classification task of the breast lump shape, the label of classification is:
Y1=[- 7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7]
Respectively correspond 14 kinds of shapes of breast lump;
In the classification task at the breast lump edge, the label of classification is:
Y2=[- 9, -8, -7, -6, -5, -4, -3, -2, -1,1,2,3,4,5,6,7,8,9]
Respectively correspond 18 kinds of different edges of breast lump;
In the classification task of breast lump BI-BADS classification, the label of classification is:
Y3=[0,1,2,3,4,5,6]
Respectively correspond 7 kind different score values of the breast lump in BI-BADS standard;
In the good pernicious classification task of the breast lump, tag along sort is:
Y4=[1,2,3]
Respectively correspond benign, the pernicious and suspicious three classes undetermined of breast lump.
5. the breast lump information extraction and classification method of breast X-ray image according to claim 3, which is characterized in that
In the loss function L that the objective function of the multi-tag multitask network includes total losses function L (W, b) and j-th of taskI, j
(W,b);
Total losses function L (W, b) is:
In formula, LjFor the loss function of j-th of task, λjFor the loss weight of the loss function of j-th of task, wherein j=1,
2,3,4;Respectively lump Shape Classification task, mass edge classification task, lump BI-BADS classification task and lump are good
Pernicious classification task;
The loss function L of j-th of taskI, j(W, b) is defined as:
Wherein, N is the total number of training sample;
I indicates i-th of sample;
xykIndicate the output valve for being predicted as k-th of label value in j-th of task after the full articulamentum of convolutional neural networks;
CjIndicate the number of tags of j-th of task.
6. the breast lump information extraction and classification method of breast X-ray image according to claim 5, which is characterized in that
In the total losses function L, the loss weight λ of the loss function of j-th of taskjRespectivelyWith 1;
The loss function L of j-th of taskI, jIn, the number of tags C of j-th of taskjRespectively 14,18,7,3.
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