CN108822162B - Synthetic method of tildipirosin intermediate - Google Patents
Synthetic method of tildipirosin intermediate Download PDFInfo
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- CN108822162B CN108822162B CN201810960316.3A CN201810960316A CN108822162B CN 108822162 B CN108822162 B CN 108822162B CN 201810960316 A CN201810960316 A CN 201810960316A CN 108822162 B CN108822162 B CN 108822162B
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Abstract
The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthetic method of a tildipirosin intermediate 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide. The method comprises the following steps: the 20-piperidyl-5-O-mycaminosyl-tylonolide and hydroiodic acid are refluxed and reacted to obtain the 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide. The method has the advantages of simple treatment process, small amount of waste liquid, low environment-friendly treatment cost, high product yield and high purity of the obtained product.
Description
Technical Field
The invention belongs to the technical field of chemical synthesis, and particularly relates to a tildipirosin intermediate and a synthetic method of tildipirosin.
Background
Tildipirosin has a chemical formula of C41H71N3O8The chemical name of the derivative is 20, 23-dipiperidinyl-5-O-mycaminosyl-tylonolide, and the structural formula is as follows:
tyldinoside (tildipiriosin), a novel macrolide semi-synthetic antibiotic developed by international limited nethernw (international BV), is a derivative of tylosin and is specially used for animals. Sterile injection containing tylonolide as a main active ingredient (trade name:
) Approved for marketing in the European union countries after approval by the European pharmaceutical administration (EMA) in 2011. Can be used for preventing and treating respiratory system infectious diseases of pig and cattle caused by sensitive bacteria such as Haemophilus parasuis, Actinobacillus pleuropneumoniae, Pasteurella multocida and Mannheim hemolyticus. After single intramuscular injection or subcutaneous injection, the Tildipirosin has the advantages of quick absorption, short peak reaching time, high concentration in lung tissues, high bioavailability, slow elimination, lasting drug effect and high safety,the single administration can provide the whole course treatment and has wide application prospect.
The antibacterial action of the tylosin is similar to that of tylosin, has strong antibacterial action on gram-positive bacteria and part of gram-negative bacteria, is particularly sensitive to pathogenic bacteria causing respiratory diseases of pigs and cows, such as pasteurella multocida, actinobacillus pleuropneumoniae, bordetella bronchiseptica, haemophilus parasuis, mannheimia haemolytica, histophilus somni, mycoplasma, spirochete, brucella and the like, has the same antibacterial action mechanism with macrolide medicaments such as tylosin and the like, can be combined with 50s subunits of nucleoproteins of sensitive bacteria to inhibit and prevent the synthesis and extension of nucleoprotein peptide chains, and further influences the synthesis of bacterial proteins.
20-piperidyl-23-iodine-5-O-mycaminosyl-tylonolide is an important intermediate for synthesizing tildipirosin, and the structural formula is as follows:
20-piperidinyl-23-iodo-5-O-mycaminosyl-tylonolide is difficult to purchase commercially and is usually synthesized by itself.
At present, the literature reports mainly include the following methods for synthesizing the intermediate of tildipirosin:
in the patent WO2008012343, tylosin is used as a raw material, and a final product is obtained by 5 steps of amination of piperidine on 20 th position, hydrolysis twice, activation on 23 th position and amination. In the method, the hydrogen bromide solution is hydrolyzed at different temperatures twice, the treatment process is complicated, the amount of waste liquid is large, and a large amount of waste liquid containing high-concentration organic solvent is generated after iodine and pyridine are used for substitution, so that the waste liquid treatment cost is greatly increased, and the yield of the method is only 12.2 percent, so that the production cost is high, and the method is not suitable for industrial production. The specific synthetic formula of the route is as follows:
patent CN102863487 reports that tylosin tartrate is used as a raw material, intermediate 23-hydroxy-5-O-mycaminosyl-tylonolide is obtained by hydrolysis, iodination is carried out, and then the intermediate and piperidine are aminated to form the final product tylosin. The method has the disadvantages that triphenylphosphine, imidazole, iodine and the like are used, anhydrous conditions are required for reaction, requirements on equipment and production conditions are high, the amount of generated high-concentration waste liquid containing imidazole and triphenylphosphine is large, the environment-friendly treatment cost is increased, the cost is not reduced, and industrial production is realized. The specific synthetic formula of the route is as follows:
U.S. Pat. No. 6,6514946 of Japan society for the research of microbiology, uses 20, 30-diiodo-5-O-mycaminose-tylonolide as raw material, reacts with piperidine in acetonitrile, and the product is obtained by column chromatography, the yield is 86.4%. The raw materials are not easy to obtain, column chromatography is utilized, the defects of the column chromatography are complex separation process, long time consumption and large solvent amount, and the efficiency is low in actual production and is not suitable for industrial production.
Patent CN105254693A discloses a preparation method of 20-piperidyl-23-I-5-O-mycaminosyl-tylonolide, which comprises the following steps: (1) preparation of 20-piperidinyl-5-O-mycaminosyl-tylonolide: dissolving 18.3g of tylosin, 4.2g of piperidine and 1.4g of formic acid in 50ml of toluene, heating to 75 ℃, reacting for 1 hour, cooling to room temperature, adding 60ml of water, heating to 35 ℃, adjusting the pH value to 2.5 by using 60% sulfuric acid solution, and hydrolyzing for 1 hour. After the reaction, the reaction mixture was cooled to room temperature, 40ml of dichloromethane was added, the pH was adjusted to 10 with 10N sodium hydroxide solution, the layers were separated, the aqueous phase was washed twice with 10ml of dichloromethane, and the organic phases were combined and dried over anhydrous sodium sulfate. (2) Preparation of 20-piperidinyl-23-I-5-O-mycaminosyl-tylonolide: adding 5.2g of hexamethyldisilazane into the dried dichloromethane solution, reacting at 30 ℃ for 2.5 hours (no ammonia gas is released), cooling the reaction solution to room temperature, adding 11.9g of N, N-diethylaniline and 10.0g of iodotrimethylsilane, reacting at 30 ℃ for 2 hours, cooling to room temperature, adding 60ml of water, stirring for 2 hours, demixing, adjusting the pH of the aqueous phase to 10 with 10N sodium hydroxide solution, filtering, washing, and drying to obtain 14.3g of the product. In the production process of the method, the release of a large amount of ammonia has high requirements on safety protection measures of production environment and professional literacy of workers, and has relatively special requirements on corrosion resistance of equipment, and meanwhile, the use of a large amount of N, N-diethylaniline and trimethyliodosilane causes the COD (chemical oxygen demand) in the production wastewater to be very high, so that the environmental-protection treatment cost is increased.
Patent CN104558076A relates to a preparation method of 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide, which comprises the following steps:
dichloromethane (120ml, 20V), pyridine (4.8g, 61mmol, 6.0eq), triphenylphosphine (15.7g, 61mmol, 6.0eq) and the mixture are added into a three-necked flask, the mixture is fully stirred until the solution is clear, the iodine simple substance (15.3g, 61mmol, 6.0eq) is added in portions at 15 ℃, after the addition is finished, the system is naturally warmed to room temperature, the reaction mixture is stirred for 1 hour, a dichloromethane (60ml, 10V) solution of the compound 3(6.0g, 10.0mmol, 1.0eq) is added dropwise at 15 ℃, after the addition is finished, the temperature is naturally raised to room temperature, the reaction mixture is stirred for 4 hours, and the raw materials are detected to disappear by HPLC. At 15 ℃, sodium sulfite solution is added to quench the reaction, the organic phase is adjusted to pH 1-2 by hydrochloric acid (1N), extracted by dichloromethane (3X 100ml), the aqueous phase is adjusted to pH 8-9 by saturated sodium bicarbonate solution, then extracted by dichloromethane (3X 100ml), the organic phases are combined, dried by anhydrous sodium sulfate, filtered and concentrated to obtain 7.17 g of yellow solid with purity of 95% and yield of 88%. According to the method, iodination reaction needs to be carried out on 2 hydroxyl groups in the reaction, the activity of the iodine is high, iodination reaction can be carried out on 4 hydroxyl groups on 20-hydroxyl-23-iodine-5-O-mycaminosyl-tylonolide at a chance, the purity of the product is low, and the post-treatment purification process is complicated.
Disclosure of Invention
In order to solve the technical problems, the invention provides a method for synthesizing a tildipirosin intermediate, which has the advantages of low requirements on equipment and production conditions, simple operation, short reaction time, capability of repeatedly recycling a catalyst, high yield, high purity of obtained products, no special solvent which is difficult to treat, less waste liquid and low waste liquid treatment cost.
The invention is realized by the following technical scheme:
a method for synthesizing a tildipirosin intermediate, wherein the tildipirosin intermediate is 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide, is characterized by comprising the following steps:
the 20-piperidyl-5-O-mycaminosyl-tylonolide and hydroiodic acid are refluxed and reacted to obtain the 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
The reaction formula is as follows:
in the synthesis method of the tildipirosin intermediate, the reaction solvent is acetonitrile.
In the synthesis method of the tildipirosin intermediate, the weight ratio of the 20-piperidyl-5-O-mycaminosyl-tylonolide to the hydroiodic acid is 1: 055-0.62.
In the synthesis method of the tildipirosin intermediate, the mass percentage concentration of the hydroiodic acid is 50-60%.
In the above method for synthesizing the tildipirosin intermediate, the concentration of hydroiodic acid is 57% by mass.
In the synthesis method of the tildipirosin intermediate, the reaction time is 4-5 h.
In the above method for synthesizing the intermediate of tildipirosin, the reaction further comprises a post-treatment step, wherein the post-treatment step comprises: after the reaction is finished, concentrating under reduced pressure until no solvent exists basically, adding water, adjusting the pH to 11-12 by using a sodium hydroxide solution, stirring for 15-20min, carrying out suction filtration, and drying to obtain a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
The detailed steps of the synthesis method of the tildipirosin intermediate are as follows:
adding 20-piperidyl-5-O-mycaminosyl-tylonolide into acetonitrile, stirring, adding hydriodic acid (57%), refluxing for 4.5h, concentrating under reduced pressure until no solvent exists basically, adding water, adjusting pH to 11-12 with sodium hydroxide solution, stirring for 15-20min, performing suction filtration, and drying to obtain 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
The method for synthesizing the tildipirosin, which comprises the method for synthesizing the intermediate of tildipirosin, comprises the following steps:
(1) preparation of 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 20-piperidyl-5-O-mycaminosyl-tylonolide into acetonitrile, stirring, adding hydriodic acid (57%), refluxing for 4.5h, concentrating under reduced pressure until no solvent exists basically, adding water, adjusting pH to 11-12 with sodium hydroxide solution, stirring for 15-20min, performing suction filtration, and drying to obtain 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide;
(2) preparation of tildipirosin
Dissolving 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide with butyl acetate, then adding piperidine and potassium carbonate, heating and refluxing for 3h, filtering, adding purified water into filtrate, adjusting the pH value to 4.0 with hydrochloric acid, separating out a water phase, washing the water phase with dichloromethane, adjusting the pH value to 10 with 4mol/L sodium hydroxide, stirring for 1h, filtering, and drying a filter cake to obtain the tildipirosin.
Compared with the prior art, the invention has the following beneficial effects:
(1) the synthesis method of the tildipirosin intermediate 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide adopts hydroiodic acid for one-time hydrolysis preparation, and has the advantages of simple treatment process, small amount of generated waste liquid, environmental protection and low treatment cost.
(2) The synthesis method of the tildipirosin intermediate 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide does not involve raw materials such as triphenylphosphine, iodine, imidazole and pyridine which have special odor or generate odor after reaction, is more green in production process, does not need special harsh conditions for reaction, has lower requirements on equipment and production conditions, avoids generating a large amount of high-concentration waste liquid, is low in environmental protection treatment cost, and is beneficial to industrial production.
(3) The synthesis method of the tildipirosin intermediate 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide has the advantages of easily obtained raw materials, no need of column chromatography, simple separation process, short time consumption, small solvent amount, high production efficiency and suitability for industrial production.
(4) The synthesis method of the tildipirosin intermediate 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide has the advantages of high product yield and high purity of the obtained product.
Detailed Description
The present invention will be further described with reference to specific examples so that those skilled in the art may better understand the present invention, but the present invention is not limited thereto.
Example Synthesis of 120-piperidinyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 71.5kg of 20-piperidyl-5-O-mycaminosyl-tylonolide (1) and 160kg of acetonitrile into a 500L reaction kettle, stirring, adding 44.1kg of hydroiodic acid (57%), performing reflux reaction for 4.5 hours, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH value to 11 by using a sodium hydroxide solution, stirring for 20min, performing suction filtration and drying to obtain 63.0kg of a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide (2), wherein the yield is 95.4% and the purity is 98.1%.
Example Synthesis of 220-piperidinyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 71.5kg of 20-piperidyl-5-O-mycaminosyl-tylonolide (1) and 160kg of acetonitrile into a 500L reaction kettle, stirring, adding 44.1kg of hydroiodic acid (57%), performing reflux reaction for 4.5 hours, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH value to 12 by using a sodium hydroxide solution, stirring for 20min, performing suction filtration and drying to obtain 63.2kg of a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide (2), wherein the yield is 95.8% and the purity is 98.3%.
Example Synthesis of 320-piperidinyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 71.5kg of 20-piperidyl-5-O-mycaminosyl-tylonolide (1) and 160kg of acetonitrile into a 500L reaction kettle, stirring, adding 39.5kg of hydroiodic acid (57%), performing reflux reaction for 4.5 hours, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH value to 12 by using a sodium hydroxide solution, stirring for 20min, performing suction filtration and drying to obtain 62.9kg of a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide (2), wherein the yield is 95.3% and the purity is 98.5%.
Example 420 Synthesis of piperidinyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 71.5kg of 20-piperidyl-5-O-mycaminosyl-tylonolide (1) and 160kg of acetonitrile into a 500L reaction kettle, stirring, adding 44.5kg of hydroiodic acid (57%), performing reflux reaction for 4.5 hours, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH value to 12 by using a sodium hydroxide solution, stirring for 20min, performing suction filtration and drying to obtain 63.2kg of a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide (2), wherein the yield is 95.7% and the purity is 98.4%.
Example 5
(1) Synthesis of 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide
Adding 71.5kg of 20-piperidyl-5-O-mycaminosyl-tylonolide (1) and 160kg of acetonitrile into a 500L reaction kettle, stirring, adding 41.7kg of hydroiodic acid (57%), performing reflux reaction for 4.5 hours, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH value to 12 by using a sodium hydroxide solution, stirring for 20min, performing suction filtration and drying to obtain 63.2kg of a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide (2), wherein the yield is 95.7% and the purity is 98.3%.
(2) Preparation of tildipirosin
In a 500L reaction kettle, dissolving 56.6kg of 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide with 200kg of butyl acetate, adding 27kg of piperidine and 55kg of potassium carbonate, heating and refluxing for 3h, filtering, adding 200kg of purified water into the filtrate, adjusting the pH to 4.0 with hydrochloric acid, separating out an aqueous phase, washing the aqueous phase with 30kg of dichloromethane, adjusting the pH to 10 with 4mol/L of sodium hydroxide, stirring for 1h, filtering, drying a filter cake to obtain 49.2kg of tedizonew, wherein the yield is 91.9%, and the HPLC purity is 98.2%.
Claims (8)
1. A synthetic method of a tildipirosin intermediate, wherein the tildipirosin intermediate is 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide, is characterized by comprising the following steps:
the 20-piperidyl-5-O-mycaminosyl-tylonolide and hydroiodic acid are refluxed and reacted to obtain the 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
2. The process for the synthesis of the tildipirosin intermediate according to claim 1, wherein the reaction solvent for the reflux reaction is acetonitrile.
3. A process for the synthesis of a tildipirosin intermediate according to claim 1, wherein the weight ratio of 20-piperidinyl-5-O-mycaminosyl-tylonolide and hydroiodic acid is 1: 0.55-0.62.
4. The method for synthesizing the tildipirosin intermediate according to claim 1, wherein the concentration of hydroiodic acid is 50 to 60% by mass.
5. The method for synthesizing the tildipirosin intermediate according to claim 1, wherein the concentration of hydroiodic acid is 57% by mass.
6. The process for the synthesis of the tildipirosin intermediate according to claim 1, wherein the reaction time of the reflux reaction is 4-5 h.
7. The method for synthesizing the tildipirosin intermediate according to claim 1, wherein the reaction further comprises a post-treatment step, wherein the post-treatment step is: after the reaction is finished, concentrating under reduced pressure until no solvent exists basically, adding water, adjusting the pH to 11-12 by using a sodium hydroxide solution, stirring for 15-20min, carrying out suction filtration, and drying to obtain a product 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
8. The method for synthesizing the tildipirosin intermediate according to claim 1, comprising the following detailed steps:
adding 20-piperidyl-5-O-mycaminosyl-tylonolide into acetonitrile, stirring, adding hydroiodic acid, refluxing for 4.5h, concentrating under reduced pressure until the mixture is basically free of solvent, adding water, adjusting the pH to 11-12 by using a sodium hydroxide solution, stirring for 15-20min, carrying out suction filtration, and drying to obtain 20-piperidyl-23-iodo-5-O-mycaminosyl-tylonolide.
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| CN101172989A (en) * | 2006-11-03 | 2008-05-07 | 上海睿智化学研究有限公司 | Method for producing 5-O-acetyl-3-deoxidization-1,2-isopropylidene-alpha-D-tetrol xylose and midbody |
| CN104497082A (en) * | 2015-01-13 | 2015-04-08 | 中国兽医药品监察所 | Synthetic method for Tildipirosin |
| CN104558076A (en) * | 2015-02-10 | 2015-04-29 | 上海皓元化学科技有限公司 | Preparation method of tildipirosin and intermediate compounds of tildipirosin |
| CN105254693A (en) * | 2015-11-13 | 2016-01-20 | 周金华 | Synthetic method for tildipirosin |
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| CN102863487B (en) * | 2012-10-08 | 2014-11-05 | 齐鲁动物保健品有限公司 | Process for preparing 20,23-bi-piperidyl-5-O-carbon mould amine glycosyl-tylosin lactone |
| CN105440093A (en) * | 2015-11-17 | 2016-03-30 | 宁夏泰瑞制药股份有限公司 | Synthetic method of tildipirosin |
| CN105384788A (en) * | 2015-12-14 | 2016-03-09 | 天津市中升挑战生物科技有限公司 | Tildipirosin preparation method |
| CN108264529A (en) * | 2016-12-30 | 2018-07-10 | 湖北回盛生物科技有限公司 | A kind of synthetic method of bis- piperidines -5-O- mycamino syl-tylono lides of 20,23- |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101172989A (en) * | 2006-11-03 | 2008-05-07 | 上海睿智化学研究有限公司 | Method for producing 5-O-acetyl-3-deoxidization-1,2-isopropylidene-alpha-D-tetrol xylose and midbody |
| CN104497082A (en) * | 2015-01-13 | 2015-04-08 | 中国兽医药品监察所 | Synthetic method for Tildipirosin |
| CN104558076A (en) * | 2015-02-10 | 2015-04-29 | 上海皓元化学科技有限公司 | Preparation method of tildipirosin and intermediate compounds of tildipirosin |
| CN105254693A (en) * | 2015-11-13 | 2016-01-20 | 周金华 | Synthetic method for tildipirosin |
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Denomination of invention: A synthetic method for the intermediate of tederoxin Effective date of registration: 20210325 Granted publication date: 20200317 Pledgee: Qilu Bank Co.,Ltd. Dezhou Qihe sub branch Pledgor: SHANDONG JIULONG HISINCE PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980002129 |
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Date of cancellation: 20230705 Granted publication date: 20200317 Pledgee: Qilu Bank Co.,Ltd. Dezhou Qihe sub branch Pledgor: SHANDONG JIULONG HISINCE PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980002129 |
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Denomination of invention: A Synthetic Method for the Intermediate of Tyrosin Effective date of registration: 20230926 Granted publication date: 20200317 Pledgee: Bank of Beijing Co.,Ltd. Jinan Branch Pledgor: SHANDONG JIULONG HISINCE PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980058868 |