CN108815683A - A kind of device that treating gall stone and its application method and application - Google Patents
A kind of device that treating gall stone and its application method and application Download PDFInfo
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- CN108815683A CN108815683A CN201810320889.XA CN201810320889A CN108815683A CN 108815683 A CN108815683 A CN 108815683A CN 201810320889 A CN201810320889 A CN 201810320889A CN 108815683 A CN108815683 A CN 108815683A
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- instillator
- bladder
- pipeline
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- 208000001130 gallstones Diseases 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 23
- 210000000232 gallbladder Anatomy 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 53
- 239000003814 drug Substances 0.000 claims abstract description 36
- 239000007924 injection Substances 0.000 claims abstract description 33
- 238000002347 injection Methods 0.000 claims abstract description 33
- 239000012530 fluid Substances 0.000 claims abstract description 32
- 239000000376 reactant Substances 0.000 claims abstract description 32
- 210000005070 sphincter Anatomy 0.000 claims abstract description 19
- 230000005540 biological transmission Effects 0.000 claims abstract description 15
- 210000000214 mouth Anatomy 0.000 claims abstract description 15
- 230000009182 swimming Effects 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 238000000338 in vitro Methods 0.000 claims description 51
- 210000002784 stomach Anatomy 0.000 claims description 28
- 238000001574 biopsy Methods 0.000 claims description 27
- 239000000835 fiber Substances 0.000 claims description 25
- 210000001198 duodenum Anatomy 0.000 claims description 16
- 239000007789 gas Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000002504 physiological saline solution Substances 0.000 claims description 9
- 210000003238 esophagus Anatomy 0.000 claims description 8
- 210000000080 chela (arthropods) Anatomy 0.000 claims description 7
- 210000001187 pylorus Anatomy 0.000 claims description 7
- 210000004185 liver Anatomy 0.000 claims description 5
- 210000000496 pancreas Anatomy 0.000 claims description 4
- 239000012495 reaction gas Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000009434 installation Methods 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 239000012730 sustained-release form Substances 0.000 claims description 2
- 239000013307 optical fiber Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 241000009298 Trigla lyra Species 0.000 abstract description 3
- 241000283216 Phocidae Species 0.000 description 32
- 239000004575 stone Substances 0.000 description 12
- 239000002775 capsule Substances 0.000 description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
- 210000000013 bile duct Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000004211 gastric acid Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010004637 Bile duct stone Diseases 0.000 description 2
- 201000009331 Choledocholithiasis Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 210000003445 biliary tract Anatomy 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000007459 endoscopic retrograde cholangiopancreatography Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
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- 239000006210 lotion Substances 0.000 description 2
- 229940126701 oral medication Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000017283 Bile Duct disease Diseases 0.000 description 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 208000004845 Cholecystolithiasis Diseases 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000002192 cholecystectomy Methods 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 210000001096 cystic duct Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 238000001595 flow curve Methods 0.000 description 1
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- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09008—Guide wires having a balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1075—Gall bladder
Abstract
This application discloses a kind of device for treating gall stone and its application method and applications.The device of the application includes place system and molten except treatment system, and place system includes duodenoscope, seal wire and conduit A；Duodenoscope extends to Boyden's sphincter for direct oral cavity, and seal wire is used to protrude into gall-bladder by duodenoscope；Conduit A is protruded into gall-bladder for being inserted in seal wire along seal wire；Conduit A front end outer side has controllable folding spherical envelope, additionally sets liquid transmission pipeline and air bag control piper in conduit A pipeline；It is molten except treatment system include using when in swimming life-buoy shape instillator, have independent inflating balloon in instillator, inflating balloon is using outer chamber as medicine holding bin；Inflating balloon is independent to be connected to reactant storehouse；Medicine holding bin has drip tube and liquid injection pipe.Medical fluid can uniformly, be continuously sent into gall-bladder by the device of the application when not influencing people's normal life, improve the molten effect except gall stone of medical fluid.
Description
Technical field
This application involves gallstone treatment apparatus fields, more particularly to a kind of device for treating gall stone and its user
Method and application.
Background technique
Gall stone refers to that biliary system generates the disease of calculus, is divided into gallbladder according to different location of the calculus in biliary system
Capsule calculus, interior calculus of bile duct and choledocholithiasis.It is shown according to nationwide investigation result, the cholecystolithiasis disease incidence in China is about
It is 52.8%, interior calculus of bile duct disease incidence is about 36.2%, and the disease incidence of choledocholithiasis is about 11%.
It mainly include at present operative treatment and non-operative treatment for the treatment method of gall stone.Wherein, operative treatment, example
Take stone, laparotomy bile duct that stone, laparoscopic resection gall-bladder, laparoscopy combined with choledochoscopy is taken to detect as traditional abdominal cuts open gallbladder
Bile duct takes stone.In operative treatment, cholecystectomy is operation the most mature and low-risk, still, nevertheless, gall-bladder is cut
Except the entire effect to body system's health still can not temporarily provide reliable definition and conclusion, needless to say other operative treatment sides
Method.
Non-operative treatment mainly includes：External knock wave shock wave lithotripsy, vitro exposure rubble, the contact of the laser lamp energy are broken
Stone, nearly endoscope minimally invasive operation take stone rubble, traditional Chinese medicine dissolve stone rubble decorporation stone.Wherein, vitro exposure rubble is set through choledochoscope
Enter electrohydraulic lithotripsy machine and carries out rubble；Traditional Chinese medicine dissolve stone rubble decorporation stone is primarily referred to as the drugs dissolve stones such as oral cholic acid.No operation is treated
Although method generates entire effect to body system unlike cut open gallbladder or gallbladder removal, still not no relative efficiency at present
Treatment method.
Summary of the invention
The purpose of the application is to provide device and its application method and the application of a kind of new treatment gall stone.
The application uses following technical scheme：
The one side of the application discloses a kind of device for treating gall stone, including place system and it is molten remove treatment system,
Place system includes duodenoscope, seal wire and conduit A；Duodenoscope is used for direct oral cavity, esophagus, stomach, pylorus, duodenum
Extend to Boyden's sphincter；Seal wire passes through Boyden's sphincter, through gallbladder for the pincers road or biopsy pipeline Jing Guo duodenoscope
General pipeline is protruded into gall-bladder；Conduit A is protruded into gall-bladder for being inserted in seal wire along seal wire；The front end outer side of conduit A has one
The spherical envelope of controllable folding, and at least two circuits are additionally provided in the pipeline of conduit A；Wherein a set of pipeline is liquid
One end of body transfer pipeline, liquid transmission pipeline extends to or stretches out the front end of conduit A, discharges for medical fluid in gall-bladder, another
The in vitro operation end of conduit A is stretched out at end；Another circuits are air bag controlled pipeline, one end of air bag controlled pipeline and spherical envelope
Connection, the other end stretch out the in vitro operation end of conduit A；It is molten except treatment system include using when in swimming life-buoy shape instillator 1, instil
An independent inflating balloon 11 is placed in device 1, the cavity other than inflating balloon 11 is medicine holding bin 12；Inflating balloon 11 and one
A independent reactant storehouse 13 is connected to, and is placed with the first reactant in inflating balloon 11, and reactant storehouse 13 places for accommodating
Two reactants, the first reactant and the second reactant react when contacting and generate gas, expand inflating balloon 11, to drug storage
Storehouse 12 is squeezed；Instillator 1 has a drip tube 14 and a liquid injection pipe 15；One end of drip tube 14 and medicine holding bin 12 connect
Logical, the other end is used for the liquid transmission pipeline of connecting conduit A；One end of liquid injection pipe 15 is connected to medicine holding bin 12, and the other end is for prolonging
It extends in vitro, in order to which medical fluid is injected medicine holding bin 12 in vitro.
In the application, duodenoscope and its application method with reference to conventional duodenoscope, can direct oral cavity, esophagus,
Stomach, pylorus, duodenum extend to Boyden's sphincter.Seal wire and its application method reference vessel the intervention operation of the application is common
Seal wire, only the seal wire of the application is the pincers road or biopsy pipeline by duodenoscope, eventually pass through Boyden's sphincter,
Through choledochus, protrude into gall-bladder.It is appreciated that the conduit A of the application is needed along seal wire direct oral cavity, esophagus, stomach, pylorus, ten
Two duodenum 12, Boyden's sphincter, choledochus, eventually enter into gall-bladder, and therefore, conduit A preferably uses hollow hose.
It should be noted that the gallstone treatment device of the application, directly can send the molten drug except gall stone into gallbladder
It is intracapsular, it more effectively molten to gall stone progress can remove, compared with existing oral drugs, using the application device, Neng Gougeng
Directly, it is molten except effect also preferably to play gall stone.It is appreciated that the key of the application is the structure of gallstone treatment device
It makes, removes drug as gall stone is molten, can be molten except scheme with reference to existing gall stone, it is not specifically limited herein.
It should also be noted that, the instillator of the application is crispaturaed in the initial state, about capsule is crispaturaed into
Size is in swimming life-buoy shape after being filled with drug in order to which it enters stomach.The instillator of swimming life-buoy shape on the one hand, can be to avoid its quilt
Suck duodenum；On the other hand, also can permit food and enter duodenum by the swimming life-buoy, i.e., do not influence food normally into
Enter duodenum.
Preferably, place system further includes conduit B and fibre scope, and conduit B and fibre scope are used to protrude into the pipeline of conduit A
It is interior, and protruded into gall-bladder along conduit A, in order to observe required examination position；The front end conduit B has an openable and closable spherical shape
Air bag, is provided with several spray-holes below air bag, and pipeline of the liquid through conduit B can be sprayed by spray-hole；And
At least a set of air bag controlled pipeline, one end of the air bag controlled pipeline of conduit B and the gas of conduit B are provided in the pipeline of conduit B
Capsule connection, the other end extend to the in vitro operation end of conduit B.
It should be noted that the effect of conduit B is primarily to solve the problems, such as that observation camera lens is blocked by dirt, convenient for light
The position that fine mirror is examined needed for clearly observing, in use, fibre scope is placed exactly between conduit A and the spherical envelope of conduit B, and
The spray-hole of conduit B is just proximate to this side of fibre scope and designs, and effect is exactly, it is contemplated that fibre scope is it is possible that camera lens
Unclear situation is sprayed washing lotion, such as clear water or physiological saline using the spray-hole of conduit B, is cleaned to fibre scope, with
This simultaneously, using conduit A siphons away the washing lotions such as clear water or physiological saline, and so circulation is until fibre scope can be observed clearly.
Therefore, if not using fibre scope to be observed, conduit B can also not be used, directly connect conduit A with instillator
It uses.
Preferably, the device of the application further include it is matching used remove system, the system of removing include gastroscope, biopsy forceps and
Electric knife, for taking out instillator 1 and conduit A.
It should be noted that the matching used gastroscope of the application, biopsy forceps and electric knife be all conventional gastroscope, biopsy forceps and
Electric knife.Due to instillator in use, being located in stomach, after the completion of use, gastroscope and biopsy forceps can be directly used
The liquid injection pipe that instillator is grabbed from stomach, so that instillator be taken out.
The another side of the application discloses application of the gallstone treatment device of the application in pancreas or the sustained-release administration of liver.
It should be noted that the gallstone treatment device of the application, key is that conduit A is protruded into required treatment in advance
Position, then recycle special designing instillator be administered, it will be understood that conduit A can not only protrude into gall-bladder content,
The molten administration except drug of gall stone is carried out, other positions can also be protruded into and be administered accordingly, such as pancreas or liver etc., as tool
The drug of body, it is not limited here.
The application method of the gallstone treatment device for disclosing the application on one side again of the application, includes the following steps, first
Duodenoscope direct oral cavity is extended into Boyden's sphincter, seal wire is protruded into along the pincers road or biopsy pipeline of duodenoscope, is worn
Boyden's sphincter is crossed, through choledochus, is protruded into gall-bladder；
Duodenoscope is removed, leaves one end in gall-bladder, the seal wire of the other end in vitro；
Then, conduit A is inserted in seal wire, conduit A direct oral cavity simultaneously protrudes into gall-bladder along seal wire, and conduit A is protruded into gall-bladder
Afterwards, seal wire is removed, leaves one end in gall-bladder, the conduit A of the other end in vitro, wherein the end conduit A, that is, conduit A in vitro
In vitro operation end；
Molten to remove in treatment system, instillator 1 is external with conduit A in vitro by its drip tube 14 in initial shape of crispaturaing
The liquid transmission pipeline of operating side is connected to, and is then protruded into stomach crispate instillator 1 and conduit A, is left the note of instillator 1
Liquid pipe 15 is in vitro；Wherein, in a kind of implementation of the application, crispate instillator 1 only about capsule size can be with
It directly eats in stomach, can also be sent in stomach using other ancillary equipments；
Finally, medical fluid to be injected to the medicine holding bin 12 of instillator 1 by liquid injection pipe 15, make the expansion of instillator 1 in swimming life-buoy shape, it will
Liquid injection pipe 15 is closed, and by the whole feeding stomach of liquid injection pipe 15, completes installation.
It should be noted that the gallstone treatment device of the application, before use, conduit A and instillator be all it is independent,
In use, being in advance in place conduit A, then conduit A is connect in vitro with instillator, then instillator is sent into stomach
Afterwards, drug is reinjected, finally liquid injection pipe 15 is closed and is sent into stomach, whole device is installed.Later, according to design, reaction
In release the second reactant to inflating balloon 11 of the meeting of agent storehouse 13 automatic slowly, contact the second reactant instead with the first reactant
Gas should be generated, make inflating balloon 11 expand, medicine holding bin 12 is squeezed, medical fluid is squeezed out by drip tube 14, medical fluid via
The liquid transmission pipeline of conduit A injects in gall-bladder.
It preferably, further include the spherical shape for making the front end conduit A by the air bag controlled pipeline of conduit A before removing seal wire
Air bag inflation, then starts to remove seal wire again.
It is appreciated that in order to avoid seal wire takes conduit A out of, therefore making the spherical envelope of the front end conduit A when removing seal wire
Inflation, plays the positioning action to conduit A.
Preferably, before being connected to drip tube 14 with the liquid transmission pipeline at the in vitro operation end of conduit A, further include by
Conduit B and fibre scope protrude into the pipeline of conduit A, and protrude into gall-bladder along conduit A, and position is examined needed for observing, specific as follows,
After conduit B stretches out conduit A, the spherical envelope of conduit A and the air bag of conduit B are opened；Clear water or physiology salt are sprayed by conduit B
Water, and extracted out clear water or physiological saline by conduit A, so circulation is until fibre scope can be observed clearly, to solve peephole
The problem of head is blocked by dirt；After the completion of observation, the air bag of conduit B is closed, conduit B and fibre scope are removed, still leave one
End is in gall-bladder, the conduit A of the other end in vitro leaves one end in gall-bladder, the conduit A of the other end in vitro.
It preferably, further include using gastroscope, biopsy forceps and electric knife by instillator 1 after completing medical fluid release, or will drop
It infuses device 1 and conduit A takes out, it is specific as follows, gastroscope is extended in stomach and is observed, if reaction gas or remaining medical fluid fill instillator
1, then instillator is cut with electric knife from the biopsy hole of gastroscope, gas and/or medical fluid are discharged；Then, from biopsy hole with biopsy forceps
The liquid injection pipe 15 for grabbing instillator 1, liquid injection pipe 15 and gastroscope are removed in vitro together；Instillator 1 is hauled out by liquid injection pipe 15 again
In vitro, while by the in vitro operation end of conduit A it also takes out of in vitro；Finally, if it is required, then continue to haul out conduit A it is external, it is complete
At the dismounting of gallstone treatment device.
It is appreciated that can be only disassembly instillator, by the in vitro operation end of conduit A also band during dismounting
After external out, if also needing to continue to be administered, a new instillator can be changed, new medical fluid is reinjected and is administered, then not
It needs to take out conduit A, also save conduit A is put into step；If you do not need to continuing to be administered, then it can pass through conduit A's
Entire conduit A is taken out in vitro operation end.
The beneficial effects of the present application are as follows：
Medical fluid can be directly sent into gall-bladder by the gallstone treatment device of the application, and it is molten except gall stone to improve medical fluid
Therapeutic effect.Directly medical fluid is sent into gall-bladder, also avoids the unstability or security risk of the administration modes such as oral.And
And the device of the application will not influence food and enter duodenum in entire use process, not influence normally to feed.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of instillator in the embodiment of the present application；
The structural representation of different conditions when Fig. 2 is the spherical envelope closure of the front end conduit A in the embodiment of the present application and opens
Figure；
Fig. 3 is that the structure of conduit A in vitro operation end liquid transmission pipeline and air bag control piper is shown in the embodiment of the present application
It is intended to；
Fig. 4 is the assembly structure diagram that conduit A in the embodiment of the present application, conduit B and fibre scope are used cooperatively；
Fig. 5 be in the embodiment of the present application gallstone treatment device in use, structural schematic diagram in vivo.
Specific embodiment
The advantages of non-operative treatment is without excision gall-bladder or to cut open gallbladder, will not generate shadow to the integrality of body system
It rings；However, the maximum deficiency of non-operative treatment is exactly that therapeutic effect is difficult to ensure.Dissolved stone medicine is especially taken orally, not only effect
It is difficult to ensure, and oral drugs are needed by positions such as oral cavity, esophagus, Stomach duodenums, shadow is inevitably caused to these positions
It rings, there are security risks.
The application is directed to the bending of gall-bladder, cystic duct, choledochus, the features such as region is narrow, and R & D design is a kind of dedicated
Device, i.e. dissolved stone medicine can be directly injected into gall-bladder by the gallstone treatment device of the application, the device of the application, can be right
The progress of the calculus such as gall-bladder, choledochus is efficient, the molten of safety removes.
In the application, the front end of conduit A refers to that conduit A protrudes into intracorporal one end, and in vitro operation end refers to be protruded into conduit A
After in vivo, extrabuccal one end is stayed in.In the application, the first reactant and the second reactant are that abutment can generate gas
Two or two groups of reactants；It is appreciated that due to safety concerns, the first reactant, the second reactant and gas generated,
It is preferably safe to the human body harmless, such as the first reactant and the second reactant are respectively acid solution and sodium bicarbonate, are generated
Gas be carbon dioxide, wherein acid solution can be gastric acid or hydrochloric acid or other harmless acidic materials
Or acidic mixture.
The application is described in further detail below by specific embodiments and the drawings.Following embodiment is only to the application
It is further described, should not be construed as the limitation to the application.
Embodiment
The gallstone treatment device of this example, including place system and it is molten remove treatment system, place system includes duodenum
Mirror, seal wire and conduit A；It is molten except treatment system include using when in swimming life-buoy shape instillator.
Wherein, duodenoscope is conventional duodenoscope, is prolonged for direct oral cavity, esophagus, stomach, pylorus, duodenum
Extend to Boyden's sphincter.Seal wire is also that blood vessel intervention operation often uses seal wire, for Jing Guo duodenoscope pincers road or biopsy
Pipeline passes through Boyden's sphincter and protrudes into gall-bladder through choledochus.
The conduit A of this example is soft hollow tube, and conduit A is protruded into gall-bladder for being inserted in seal wire along seal wire；Such as Fig. 2
Shown, in Fig. 2,2 be conduit A, and the front end outer side of conduit A has the spherical envelope 21 of a controllable folding, also, such as Fig. 3
It is shown, two circuits are additionally provided in the pipeline of conduit A；Wherein a set of pipeline is liquid transmission pipeline 22, liquid delivery tube
The front end of conduit A is stretched out in the one end on road, discharges for medical fluid, and to discharge medical fluid to gall-bladder, the other end stretches out conduit A's
In vitro operation end；Another circuits are air bag controlled pipeline 23, and one end of air bag controlled pipeline is connected to spherical envelope, the other end
Stretch out the in vitro operation end of conduit A.
The molten of this example removes in treatment system, in the instillator 1 of swimming life-buoy shape when including using, as shown in Figure 1, in instillator 1
It is placed with an independent inflating balloon 11, the cavity other than inflating balloon 11 is medicine holding bin 12；Inflating balloon 11 and one are solely
Vertical reactant storehouse 13 is connected to, and is placed with the first reactant in inflating balloon 11, the second reactant is placed in reactant storehouse 13,
First reactant and the second reactant react when contacting and generate gas, expand inflating balloon 11, carry out to medicine holding bin 12
It squeezes；Instillator 1 has a drip tube 14 and a liquid injection pipe 15；One end of drip tube 14 is connected to medicine holding bin 12, another
End is used for the liquid transmission pipeline of connecting conduit A；One end of liquid injection pipe 15 is connected to medicine holding bin 12, and the other end is for extending to body
Outside, in order in vitro by medical fluid injection medicine holding bin 12.Also, inflating balloon 11 is in the side close to drip tube 14 by isolation film
111 isolation, so that inflating balloon 11 will not be expanded to the position of drip tube 14, avoid inflating balloon 11 from closing drip tube 14,
Actually control inflating balloon 11 is expanded along a direction of the instillator of swimming round.The instillator 1 of this example is defeated
Before entering medical fluid, it is initially crimped configuration, instillator is integrally in that about capsule is big in addition to drip tube 14 and liquid injection pipe 15
It is small.
In a kind of implementation of this example, the first reactant is sodium bicarbonate, is placed in inflating balloon, the second reactant is
Gastric acid reacts after reacted dose of storehouse of the second reactant enters inflating balloon with sodium bicarbonate, generates carbon dioxide, makes inflating balloon
It is inflated.
For the ease of examining position needed for observing, in a kind of improvement project of this example, place system further includes conduit B and light
Fine mirror, as shown in figure 4, in figure, 21 be the spherical envelope of conduit A, 42 be conduit B, 43 be fibre scope, 421 be conduit B gas
The spray-hole that capsule, 422 are conduit B, conduit B and fibre scope protrude into gall-bladder for protruding into the pipeline of conduit A along conduit A,
In order to observe required examination position；The front end conduit B has the air bag of an openable and closable spherical shape, is provided with below air bag
Several spray-holes, pipeline of the liquid through conduit B, can be sprayed by spray-hole；And it is provided in the pipeline of conduit B a set of
One end of air bag controlled pipeline, the air bag controlled pipeline of conduit B is connected to the air bag of conduit B, and the other end extends to the body of conduit B
Outer operating side.
In addition, dismantling for convenience, the gallstone treatment device of this example further further includes that matching used remove is
System, the system of removing includes gastroscope, biopsy forceps and electric knife, for taking out instillator 1 and conduit A.Wherein, gastroscope, biopsy forceps and
Electric knife is all conventional gastroscope, biopsy forceps and electric knife.When dismantling the device of this example, since instillator is located in stomach,
Therefore after the completion of use, the liquid injection pipe that gastroscope and biopsy forceps grab instillator from stomach can be directly used, by liquid injection pipe with
Gastroscope pulls out together, then again pulls out instillator, finally hauls out conduit A, that is, completes disassembly, easy to use.
In order to which the gallstone treatment device preferably to this example is said, this example provides a kind of detailed application method,
It is specific as follows：
1, step is placed
A. duodenoscope direct oral cavity, esophagus, stomach, pylorus, duodenum are extended into Boyden's sphincter；
B. seal wire enters choledochus across sphincter, marches in gall-bladder through pincers road or biopsy pipeline；
b1：If feeling that conduit A is entered Boyden's sphincter, and there are difficulty, or can be more difficult in subsequent process
Insertion, can use duodenoscope carry out it is conventional through endoscopic retrograde cholangiopancreatography (abbreviation ERCP), by choledochus
Sphincterotomy；
b2：In addition, conventional angiography (abbreviation DSA) observation seal wire whereabouts can be used during seal wire protrudes into；
C. after seal wire being protruded into gall-bladder, slowly remove duodenoscope, leave seal wire, at this time seal wire one end gall-bladder,
One end is in vitro；
D. conduit A is inserted in seal wire, direct oral cavity, esophagus, stomach, pylorus, duodenum, sphincter, choledochus proceed to gall-bladder
It is interior；
E. slowly remove seal wire, at this time the one end conduit A in gall-bladder, one end in vitro；
When removing seal wire, to prevent conduit A from being pulled outward by seal wire, at the in vitro operation end of conduit A, air bag is controlled
Control piper opens spherical envelope, and air bag controlled pipeline is sealed, and avoids gas leakage, and spherical envelope is made to maintain opening shape
State stablizes the front end of conduit A in gall-bladder；
F. if not using DSA, required examination position need to be observed using fibre scope, fibre scope and conduit B is existed
The front end conduit A is advanced into conduit A；Fibre scope is easy therefore to be carried out in accordance with the following methods by substance dirt screening camera lens in choledochus
Observation：
1. opening the air bag of the front end conduit B after fibre scope and conduit B are extend into designated position；
2. being passed through clear water or physiological saline into conduit B, is sprayed by its spray-hole, fibre scope is cleaned, it is same with this
When, clear water or physiological saline are extracted by conduit A, intracorporal clear water or physiological saline are extracted out；
3. being passed through and detaching for clear water or physiological saline is persistently carried out, until fibre scope can be observed clearly；
4. examining position needed for observation；
5. closing the air bag of the front end conduit B, fibre scope and conduit B are removed；
Finally, observation finishes, only stay one end of conduit A in gall-bladder, the other end in vitro.Wherein, if you do not need into
Row examination position observation, then do not need step f, can directly carry out subsequent step after removing seal wire.
2, instillation therapeutic progresses
The original state of instillator in vitro is receipts state of curling up, i.e., entire instillator is integrally crispaturaed big in about capsule
Small, there are two pipe on capsule, one is shorter drip tube, and one is longer liquid injection pipe, and specifically used method is as follows：
1) liquid transmission pipeline that will be left in external conduit A, is connected to the drip tube of instillator；
2) after the completion of connecting, instillator and conduit A are stayed in into external one end, direct oral cavity, which integrally pushes, to be referred in stomach, and will
Liquid injection pipe one end of instillator stays in outside oral cavity；
3) medicine holding bin that instillator is filled through the molten medical fluid except calculus of liquid injection pipe makes medicine holding bin expansion in swimming round, so
Afterwards, liquid injection pipe is knotted and is pushed in stomach after sealing.
Instillator is the open configuration of swimming round in stomach at this time, and internal total measurement (volume) is certain value.
A. the second reactant in reactant storehouse is anti-with first in inflating balloon 11 slowly in overflow to inflating balloon 11
It answers object to react, generates gas.
B. the gas generated expands inflating balloon, ties up medicine holding bin volume, and medical fluid in medicine holding bin is injected through drip tube
The liquid transmission pipeline of conduit A, and in lasting input gall-bladder, contact medical fluid directly directly with the knot in gall-bladder, by gallbladder knot
Shi Rong is removed；As shown in figure 5, dotted line 51 is flow curve of the medical fluid with conduit A in Fig. 5.In Fig. 5,1 be instillator, 52 be oesophagus,
53 expression stomaches, 54 expression ductus pancreaticus, 55 be Boyden's sphincter, 56 be duodenum, 57 be choledochus, 58 be gall-bladder, 59 be liver,
50 be gall stone.
In general, different according to used medical fluid, after 10~50 hours, it can be completed that calculus is molten to be removed, this mistake
The instillator of journey went swimming round, can either avoid it from being inhaled into duodenum, and food can allow for normally enter 12 fingers
Enteral does not influence normally to feed.
3, it removes
Calculus is molten remove after, the gallstone treatment device of this example need to be removed, it is specific as follows：
A. it is extended in stomach and is observed with gastroscope, if reaction gas or remaining medical fluid fill instillator, from biopsy hole with electric knife
Instillator is cut, its atrophy is made；
B. it is removed simultaneously from biopsy hole with the liquid injection pipe and gastroscope of biopsy forceps crawl instillator external；
C. it pulls liquid injection pipe to haul out instillator in vitro, and the in vitro operation end of conduit A is also pulled out in vitro；
D. its spherical envelope is controlled from the in vitro operation end of conduit A to close, then conduit A is hauled out to external, completion disassembly.
Medical fluid can directly be sent into gall-bladder by the gallstone treatment device of this example, and it is molten except gall stone to improve medical fluid
Therapeutic effect, it is highly-safe.Also, in entire use process, will not influence food and enter duodenum, do not influence normally into
Food.The gallstone treatment device of this example specifically protrudes into position according to conduit A, and the different pharmaceutical specifically used, can be with
For the administration of pancreas, liver etc., also, the speed of expansion of the inflating balloon of instillator is controlled, control drug can be played and slowly released
The effect put.
The foregoing is a further detailed description of the present application in conjunction with specific implementation manners, and it cannot be said that this Shen
Specific implementation please is only limited to these instructions.For those of ordinary skill in the art to which this application belongs, it is not taking off
Under the premise of from the application design, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to the protection of the application
Range.
Claims (8)
1. a kind of device for treating gall stone, it is characterised in that：Including place system and it is molten remove treatment system, the place system
Including duodenoscope, seal wire and conduit A；
The duodenoscope extends to Boyden's sphincter for direct oral cavity, esophagus, stomach, pylorus, duodenum；The seal wire is used
In pincers road or biopsy pipeline Jing Guo the duodenoscope, passes through Boyden's sphincter and protruded into gall-bladder through choledochus；
The conduit A is protruded into gall-bladder for being inserted in the seal wire along seal wire；The front end outer side of conduit A is controllable with one
The spherical envelope of folding is made, and is additionally provided at least two circuits in the pipeline of conduit A；Wherein a set of pipeline is that liquid is defeated
Pipeline is sent, one end of liquid transmission pipeline extends to or stretch out the front end of conduit A, discharges for medical fluid in gall-bladder, the other end is stretched
The in vitro operation end of conduit A out；Another circuits are air bag controlled pipeline, one end of air bag controlled pipeline and the spherical envelope
Connection, the other end stretch out the in vitro operation end of conduit A；
It is described it is molten except treatment system include using when in swimming life-buoy shape instillator (1), be placed in instillator (1) one it is independent
Inflating balloon (11), the cavity other than inflating balloon (11) are medicine holding bin (12)；Inflating balloon (11) independent is reacted with one
Agent storehouse (13) connection, inflating balloon (11) is interior to be placed with the first reactant, and reactant storehouse (13) place the second reaction for accommodating
Object, the first reactant and the second reactant react when contacting and generate gas, expand inflating balloon (11), to medicine holding bin
(12) it is squeezed；
The instillator (1) has a drip tube (14) and a liquid injection pipe (15)；One end of the drip tube (14) and storage
Medicine storehouse (12) connection, the other end are used to connect the liquid transmission pipeline of the conduit A；One end of the liquid injection pipe (15) is connected to storage
Medicine storehouse (12), the other end is external for extending to, in order to which medical fluid is injected the medicine holding bin (12) in vitro.
2. the apparatus according to claim 1, it is characterised in that：The place system further includes conduit B and fibre scope, conduit
B and fibre scope protrude into gall-bladder for protruding into the pipeline of the conduit A along conduit A, in order to observe required examination portion
Position；The front end conduit B has the air bag of an openable and closable spherical shape, several spray-holes, liquid warp are provided with below air bag
The pipeline of conduit B can be sprayed by the spray-hole；And at least a set of air bag controlled pipe is provided in the pipeline of conduit B
The one end on road, the air bag controlled pipeline of conduit B is connected to the air bag of conduit B, and the other end extends to the in vitro operation end of conduit B.
3. the apparatus according to claim 1, it is characterised in that：Further include it is matching used remove system, described remove is
System includes gastroscope, biopsy forceps and electric knife, for taking out the instillator (1) and conduit A.
4. application of the device according to claim 1-3 in pancreas or the sustained-release administration of liver.
5. the application method of device according to claim 1-3, it is characterised in that：Include the following steps,
Duodenoscope direct oral cavity is first extended into Boyden's sphincter, seal wire is stretched along the pincers road or biopsy pipeline of duodenoscope
Enter, passes through Boyden's sphincter and protruded into gall-bladder through choledochus；
Duodenoscope is removed, leaves one end in gall-bladder, the seal wire of the other end in vitro；
Then, conduit A is inserted in seal wire, conduit A direct oral cavity simultaneously protrudes into gall-bladder along seal wire, after conduit A is protruded into gall-bladder, removes
Except seal wire, one end is left in gall-bladder, the conduit A of the other end in vitro, wherein the end conduit A, that is, conduit A in vitro is external
Operating side；
Molten to remove in treatment system, instillator (1) is external with conduit A in vitro by its drip tube (14) in initial shape of crispaturaing
The liquid transmission pipeline of operating side is connected to, and is then protruded into stomach crispate instillator (1) and conduit A, is left instillator (1)
Liquid injection pipe (15) in vitro；
Finally, making instillator (1) expansion in swimming life-buoy the medicine holding bin (12) of medical fluid injection instillator (1) by liquid injection pipe (15)
Shape closes liquid injection pipe (15), and liquid injection pipe (15) is integrally sent into stomach, completes installation.
6. application method according to claim 5, it is characterised in that：It further include by conduit A before removing seal wire
Air bag controlled pipeline inflates the spherical envelope of the front end conduit A, then starts to remove seal wire again.
7. application method according to claim 5, it is characterised in that：By the in vitro operation of drip tube (14) and conduit A
It further include protruding into conduit B and fibre scope in the pipeline of conduit A, and protruded into along conduit A before the liquid transmission pipeline connection at end
In gall-bladder, position is examined needed for observing, it is specific as follows,
After conduit B stretches out conduit A, the spherical envelope of conduit A and the air bag of conduit B are opened；
Clear water or physiological saline are sprayed by conduit B, and is extracted out clear water or physiological saline by conduit A, so circulation is until optical fiber
Mirror can be observed clearly, to solve the problems, such as that observation camera lens is blocked by dirt；
After the completion of observation, close conduit B air bag, conduit B and fibre scope are removed, still leave one end in gall-bladder, it is another
The conduit A of end in vitro leaves one end in gall-bladder, the conduit A of the other end in vitro.
8. according to the described in any item application methods of claim 5-7, it is characterised in that：Further include complete medical fluid release after,
Using gastroscope, biopsy forceps and electric knife by instillator (1), or instillator (1) and conduit A taken out, it is specific as follows,
Gastroscope is extended in stomach and is observed, if reaction gas or remaining medical fluid fill instillator (1), from the biopsy hole of gastroscope with
Electric knife cuts instillator, and gas and/or medical fluid are discharged；
Then, liquid injection pipe (15) and gastroscope are removed together with the liquid injection pipe (15) of biopsy forceps crawl instillator (1) from biopsy hole
In vitro；
Instillator (1) is hauled out in vitro by liquid injection pipe (15) again, while the in vitro operation end of conduit A also being taken out of in vitro, with side
Just conduit A is taken out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810320889.XA CN108815683A (en) | 2018-04-11 | 2018-04-11 | A kind of device that treating gall stone and its application method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810320889.XA CN108815683A (en) | 2018-04-11 | 2018-04-11 | A kind of device that treating gall stone and its application method and application |
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| CN108815683A true CN108815683A (en) | 2018-11-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810320889.XA Pending CN108815683A (en) | 2018-04-11 | 2018-04-11 | A kind of device that treating gall stone and its application method and application |
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Effective date of registration: 20200426 Address after: 518052 Guangdong Shenzhen Nanshan District Shahe East 186 No. 5 32F Applicant after: SHENZHEN XISIKAI TECHNOLOGY Co.,Ltd. Applicant after: Shenzhen shenghang Medical Co., Ltd Address before: 518052 Guangdong Shenzhen Nanshan District Shahe East 186 No. 5 32F Applicant before: SHENZHEN XISIKAI TECHNOLOGY Co.,Ltd. Applicant before: SHENZHEN SHENGHANG TECHNOLOGY Co.,Ltd. |