CN108815583A - A kind of super hydrophilic antibacterial ureter and preparation method thereof based on amino nano silver molecular brush - Google Patents
A kind of super hydrophilic antibacterial ureter and preparation method thereof based on amino nano silver molecular brush Download PDFInfo
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Abstract
The present invention relates to a kind of super hydrophilic antibacterial ureter and preparation method thereof based on amino nano silver molecular brush, PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, after acidification, PVC ureter is added in certain density dissaving polymer, then, the PVC ureter that amination is modified sufficiently is washed through distilled water, obtain super hydrophilic antibacterial PVC ureter, the PVC ureter that amination is modified is impregnated into silver nitrate solution again, washing, dry to get in-situ preparation polymer " gripping " nanometer silver coating array.The present invention is compared with conventional hydrophobic type ureter, this method looks for another way, PVC ureter highly-hydrophilic, hydration shell can be formed with water molecules, prevent protein adherence tube wall in urine, antibiotic property outstanding using dissaving polymer cladding nano silver simultaneously, antibiotic property are up to 99% or more, realize urine bacterium infection integrated protection well.The preparation method simple process, wearability and durability are good, spectrum antibacterial, and antibiotic property is strong and has no drug resistance.
Description
Technical field
The present invention relates to medical material tech fields, and in particular to a kind of super hydrophilic anti-based on amino nano silver molecular brush
Bacterium ureter and preparation method thereof.
Background technique
Ureter is the common drainage tool of Urology Surgery.Prevention is applied to kidney or ureter stone, uronephrosis, ureter
The dilation therapy of the operations such as tumour, kidney transplant and ureterostenosis.However, traditional ureter easily causes complication
(78%).And urinary tract infections is that wherein one of most typical complication, incidence are directly related with bracket indwelling time.By planting
Enter urinary tract infections caused by ureter and belong to catheter associated urinary tract infections (CAUTI), is a kind of extremely common nosocomial infection.
Clinically the indwelling time of ureter bracket is generally 4 weeks, even with the double J-type brackets of the preferable import of prognosis, art the latter
Infection rate is still up to 26.47% in month.Therefore, certain surface treatment is carried out to ureter bracket, improve its anti-microbial property to prevent
Only urinary tract infections has important clinical meaning.
Currently, urinary infection accounts for the 30~40% of nosocomial infection, wherein 75~80% urinary tract infections is indwelling urine output
Caused by pipe.The distribution and drug resistance correlative study of ureter Urinary Tract Pathogens: A show the pathogen strain bacterium isolated in urine
In, escherichia coli accounts for 41.2%, and Klebsiella Pneumoniae accounts for 16.8%, and enterococcus faecalis and staphylococcus account for 8.3% He respectively
6.9%.Wherein enterococcus faecalis and staphylococcus aureus are because secretion is more and adhesion is strong, easily on ureter bracket surface
Form biomembrane.Therefore, the anti-infectious main task of ureter is to realize broad-spectrum antiseptic and low drug resistance.
It is the immediate cause for leading to infection that protein and bacterium, which are easily adhered ureter,.When being inserted into ureter, Urinary
Mucous membrane is destroyed in road, anti-infection ability decline.Meanwhile bacterium easily attaches to ureter and drives in the wrong direction therewith, is dispersed throughout entire urine
Road.The stronger bacterium of a small amount of adhesion first sticked causes more bacterial adhesions in urine output pipe surface secretion adhesive, gradually shape
At bacterium colony.Enter the release stage after bacterium colony is mature, finally forms biomembrane in implant surface and cause urinary tract infections.Due to urine output
The length that pipe holder is implanted into urethra is longer, and the adhesive area of bacterium is big, and there is biofilm formation on 90% ureter bracket surface,
In, the higher (2*10 of biofilm density2~2*107) account for 55%.Therefore, the adherency for reducing bacterium and protein solves urinary system
The basic problem of togetherness dye.
Nano metal is to make metal nano it to generate antibacterial action using nanotechnology.As nano silver makes killing for silver
Bacterium ability produces qualitative leap, is only the bactericidal effect that can produce strength with minimal amount of nano silver.What nano silver was played
Antibacterial effect, bactericidal mechanism is similar with catalyst reaction, when nano silver is close to bacterium, the silver-colored cation (Ag of the activity generated
+) the oxygen metabolism enzyme (- SH) of substance and bacterium surface combines, destroy the activity of bacterial cell synzyme, bacterial metabolism is blocked to make it
It is choked to death.So the lasting and slow release of metal cation is that it guarantees that sterilization and antibacterial effect are held in nano-metal particle
The basic reason of long row.Common nano-metal particle is unstable, easily assembles, it is more difficult to which Direct Uniform is coated in various catheters
Surface, so being typically all to use to be mingled in urethral catheterization tube material, Chinese patent CN1736504 discloses a kind of nano combined anti-
Bacterium rubber urinary catheter is compounded with anti-biotic material layer in urethral catheterization outer surface of tube body, and anti-biotic material layer is substantially resisted by organic nano
Microbial inoculum and inorganic nano antiseptic compound, and this technical costs is high, by the rubber blank not demoulded be directly mixed in silver from
Son may also influence other performances of urethral catheterization tube material, while and the antibacterial effect of catheter is a small amount of nano silver by surface
Coating determines.Chinese patent CN101912638A discloses a kind of nano silver-carrying-silicon dioxide catheter and its production method, will
Nano silver-carrying-silicon dioxide antibacterial agent is added in silica gel or latex, stirs evenly molding, this method silver ion may also influence to lead
Other performances of urinary catheter material, and the antibacterial effect of catheter is only determined by a small amount of nanometer of silver coating on surface.It is Chinese special
Sharp CN205127090U discloses a kind of Medical antibiosis catheter, and the outer surface of urethral catheterization tube body is coated with nanometer silver coating, should
Method is in existing antibiotic catheters, and by the substance spray containing Ag ion in urethral catheterization tube outer surface, coating is easy to from leading
Urinary catheter surface falls off or aoxidizes in vivo.
Summary of the invention
The present invention overcomes the deficiencies of the prior art and provide a kind of super hydrophilic antibacterial urine output based on amino nano silver molecular brush
The preparation method of pipe, this approach includes the following steps：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, certain PH,
Graft reaction is carried out under the conditions of temperature, obtains the PVC ureter of amination modification；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
(4) step (3) is shown that PVC ureter washs；
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
(6) step (5) is shown that PVC ureter washs, then dried；
(7) to step (6), treated that PVC ureter sterilized, is packed.
Preferably, potassium permanganate concentration is 30~60% in the step (1), and mass volume ratio is 0.1~1g/L, sulfuric acid
For standard concentrated sulfuric acid reagent, concentration 95~98%.
Preferably, souring temperature is 30~45 DEG C in the step (1), and acidificatoin time is 1~300min.
Preferably, in the step (2) dissaving polymer be amino fluidized polymer, i.e., amine-terminated hyperbrancedization polyamide or
End carboxyl super branched polymer, concentration are 0.01~10g/L.
Preferably, in the step (2) pH value be 5~11, temperature be 50~98 DEG C, the graft reaction time be 15~
120min。
Preferably, the ethanol solution in the step (3) is straight alcohol solution, and the straight alcohol solution dip time is 10
~120min, so that polymer scopiform.
Preferably, washing solution is distilled water in the step (4)；AgNO in the step (5)3Solution concentration is
0.078~0.39g/L, dip time are 10~60min.
Preferably, step (6) the washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 80~120
DEG C, 10~60min of drying time；Sterilizing in step (7) is ethylene oxide sterilizing, and sterilization time is 30~60min.
It is a kind of super hydrophilic anti-based on amino nano silver molecular brush the present invention also provides being obtained according to above-mentioned preparation method
Bacterium ureter, PVC ureter include ontology and hydrophilic antimicrobial layer, and the hydrophilic antimicrobial layer is receiving for in-situ preparation polymer overmold
Rice silver coating, the antibiotic property of prepared super hydrophilic antibacterial ureter are up to 99% or more.
Preferably, embedded combination is intersected between the ontology and hydrophilic antimicrobial layer, forms a substance binder course, it is hydrophilic
Antibiotic layer can form positively charged hydration shell with water molecules, prevent bacterium and protein adherence tube wall in urine, tool
There are excellent wearability, durability and has no drug resistance.
Present invention advantageous effects obtained：
1, the functional anti-infection ureter of the PVC prepared by the present invention, simple process, stability is good, coating uniform, antibacterial
For effect up to 99% or more, biological safety is high, can be applied to the fields such as health care.
2, the dissaving polymer that the present invention uses is a kind of polymer of spherical cavity structure, and surface has height cladodification
With the amino group of liberalization, can efficiently be grafted to potassium permanganate oxidation PVC ureter, formed high uniformity, it is highly stable and
The cationic hydrated sheath of superelevation durability.
3, the hyperbranched polymer molecule sphere that the present invention uses is formed by coating with very high space potential and position
Resistance, is capable of forming more huge hydrated sheath after being combined with water, to effectively completely cut off protein and bacterium, prevent its bonding can
It can property；The nano silver of dissaving polymer package has outstanding antibacterial ability simultaneously, can also even if there is part bacterium to seek connections with
Anti-infectious function is realized by bactericidal effect.
4, the nano silver that the present invention uses can also actively kill the bacterium in ureter by actively discharging silver ion,
And there is strong antibiotic property, broad-spectrum antiseptic and low drug resistance.
Detailed description of the invention
Fig. 1 is that the present invention is based on the super hydrophilic antibacterial ureter surface structure schematic diagrames of amino nano silver molecular brush.
Detailed description of the invention：1, ontology；2, substance binder course；3, hydrophilic antimicrobial layer.
Specific embodiment
Technical solution of the present invention is described in detail below by specific embodiment, is only of the invention preferred
Ground or preferable embodiment, are not intended to limit protection scope of the present invention.
Embodiment 1
A kind of preparation method of the super hydrophilic antibacterial ureter based on amino nano silver molecular brush, this method includes following step
Suddenly：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
Wherein potassium permanganate concentration is 30%, mass volume ratio 0.1g/L, and sulfuric acid is standard concentrated sulfuric acid reagent, not plus dilute
It releases, concentration 95~98%；Souring temperature is 30 DEG C, and acidificatoin time 300min, PVC urine output pipe surface carries out in sulfuric acid solution
Oxidation reaction, surface are oxidized.
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, certain PH,
Graft reaction is carried out under the conditions of temperature, obtains the PVC ureter of amination modification；
Wherein dissaving polymer is amino fluidized polymer, i.e. amine-terminated hyperbrancedization polyamide, concentration 0.01g/L；PH
Value is 5, and temperature is 50 DEG C, and the graft reaction time is 120min；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
Wherein ethanol solution concentration is straight alcohol, undiluted, dip time 10min, so that polymer scopiform, forms
Chemical graft is formed by monolayer interface on the surface of the material for polymer brush, i.e. polymer.
(4) step (3) is shown that PVC ureter washs；
Wherein washing solution is distilled water, sufficiently cleans, removes non-grafted polymer.
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
Wherein AgNO3Solution concentration is 0.078mg/L, and dip time 60min utilizes the reduction of dissaving polymer
Property, in polymer cavity inside in-situ preparation nano silver.
(6) step (5) is shown that PVC ureter washs, then dried；
Wherein washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 80 DEG C, drying time 60min.
(7) to step (6), treated that PVC ureter sterilized, is packed.
Wherein sterilizing is ethylene oxide sterilizing, sterilization time 60min, the PVC ureter vacuum sealed package after sterilizing,
And transport storage at normal temperature.
A kind of super hydrophilic antibacterial ureter based on amino nano silver molecular brush manufactured in the present embodiment, PVC ureter packet
Ontology and hydrophilic antimicrobial layer are included, hydrophilic antimicrobial layer is the nanometer silver coating of in-situ preparation polymer overmold；Ontology and hydrophilic antimicrobial
Intersect embedded combination between layer, forms a substance binder course, hydrophilic antimicrobial layer can form positively charged with water molecules
The hydration shell of lotus prevents bacterium and protein adherence tube wall in urine, has excellent wearability, durability and has no drug resistance.
Embodiment 2
A kind of preparation method of the super hydrophilic antibacterial ureter based on amino nano silver molecular brush, this method includes following step
Suddenly：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
Wherein potassium permanganate concentration is 45%, mass volume ratio 5g/L, and sulfuric acid is standard concentrated sulfuric acid reagent, not plus dilute
It releases, concentration 95~98%；Souring temperature is 38 DEG C, and acidificatoin time 150min, PVC urine output pipe surface carries out in sulfuric acid solution
Oxidation reaction, surface are oxidized.
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, certain PH,
Graft reaction is carried out under the conditions of temperature, obtains the PVC ureter of amination modification；
Wherein dissaving polymer is amino fluidized polymer, i.e., end carboxyl super branched polyamide, concentration 5g/L；PH value is
8, temperature is 75 DEG C, and the graft reaction time is 70min；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
Wherein ethanol solution concentration is straight alcohol, undiluted, dip time 65min, so that polymer scopiform, forms
Chemical graft is formed by monolayer interface on the surface of the material for polymer brush, i.e. polymer.
(4) step (3) is shown that PVC ureter washs, removes non-grafted polymer；
Wherein washing solution is distilled water, is sufficiently cleaned.
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
Wherein AgNO3Solution concentration is 0.234mg/L, and dip time 35min utilizes the reduction of dissaving polymer
Property, in polymer cavity inside in-situ preparation nano silver.
(6) step (5) is shown that PVC ureter washs, then dried；
Wherein washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 100 DEG C, drying time 35min.
(7) to step (6), treated that PVC ureter sterilized, is packed.
Wherein sterilizing is ethylene oxide sterilizing, sterilization time 45min, the PVC ureter vacuum sealed package after sterilizing,
And transport storage at normal temperature.
A kind of super hydrophilic antibacterial ureter based on amino nano silver molecular brush manufactured in the present embodiment, PVC ureter packet
Ontology and hydrophilic antimicrobial layer are included, hydrophilic antimicrobial layer is the nanometer silver coating of in-situ preparation polymer overmold；Ontology and hydrophilic antimicrobial
Intersect embedded combination between layer, forms a substance binder course, hydrophilic antimicrobial layer can form positively charged with water molecules
The hydration shell of lotus prevents bacterium and protein adherence tube wall in urine, has excellent wearability, durability and has no drug resistance.
Embodiment 3
A kind of preparation method of the super hydrophilic antibacterial ureter based on amino nano silver molecular brush, this method includes following step
Suddenly：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
Wherein potassium permanganate concentration is 60%, mass volume ratio 1g/L, and sulfuric acid is standard concentrated sulfuric acid reagent, not plus dilute
It releases, concentration 95~98%；Souring temperature is 45 DEG C, and acidificatoin time 1min, PVC urine output pipe surface carries out oxygen in sulfuric acid solution
Change reaction, surface is oxidized.
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, certain PH,
Graft reaction is carried out under the conditions of temperature, obtains the PVC ureter of amination modification；
Wherein dissaving polymer is amino fluidized polymer, i.e. amine-terminated hyperbrancedization polyamide, concentration 10g/L；PH value
It is 11, temperature is 98 DEG C, and the graft reaction time is 10min；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
Wherein ethanol solution concentration is straight alcohol, undiluted, dip time 120min, so that polymer scopiform, shape
At polymer brush, i.e., chemical graft is formed by monolayer interface to polymer on the surface of the material.
(4) step (3) is shown that PVC ureter washs, removes non-grafted polymer；
Wherein washing solution is distilled water, is sufficiently cleaned.
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
Wherein AgNO3Solution concentration is 0.39mg/L, dip time 10min, using the reproducibility of dissaving polymer,
In polymer cavity inside in-situ preparation nano silver.
(6) step (5) is shown that PVC ureter washs, then dried；
Wherein washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 120 DEG C, drying time 10min.
(7) to step (6), treated that PVC ureter sterilized, is packed.
Wherein sterilizing is ethylene oxide sterilizing, sterilization time 30min, the PVC ureter vacuum sealed package after sterilizing,
And transport storage at normal temperature.
A kind of super hydrophilic antibacterial ureter based on amino nano silver molecular brush manufactured in the present embodiment, PVC ureter packet
Ontology and hydrophilic antimicrobial layer are included, hydrophilic antimicrobial layer is the nanometer silver coating of in-situ preparation polymer overmold；Ontology and hydrophilic antimicrobial
Intersect embedded combination between layer, forms a substance binder course, hydrophilic antimicrobial layer can form positively charged with water molecules
The hydration shell of lotus prevents bacterium and protein adherence tube wall in urine, has excellent wearability, durability and has no drug resistance.
Embodiment 4
A kind of preparation method of the super hydrophilic antibacterial ureter based on amino nano silver molecular brush, this method includes following step
Suddenly：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
Wherein potassium permanganate is as catalyst, and concentration is 40~50%, and mass volume ratio is 0.3~0.7g/L, and sulfuric acid is
Standard concentrated sulfuric acid reagent not plus dilutes, concentration 95~98%；Souring temperature be 35~40 DEG C, acidificatoin time be 100~
200min, PVC urine output pipe surface carry out oxidation reaction in sulfuric acid solution, and surface is oxidized.
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, certain PH,
Graft reaction is carried out under the conditions of temperature, obtains the PVC ureter of amination modification；
Wherein dissaving polymer is amino fluidized polymer, and amino fluidized polymer is amine-terminated hyperbrancedization polyamide or end carboxylic
Base ultrabranching polyamide, concentration are 4~7g/L；PH value be 7~9, temperature be 65~85 DEG C, the graft reaction time be 40~
95min, grafted by super branched polymer to PVC urine output pipe surface；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
Wherein ethanol solution concentration is straight alcohol, undiluted, and dip time is 40~90min, so that polymer scopiform,
Polymer brush is formed, i.e., chemical graft is formed by monolayer interface to polymer on the surface of the material.
(4) step (3) is shown that PVC ureter washs, removes non-grafted polymer；
Wherein washing solution is distilled water, is sufficiently cleaned.
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
Wherein AgNO3Solution concentration is 0.12~0.31mg/L, and dip time is 25~45min, utilizes hyperbranched polymerization
The reproducibility of object, in polymer cavity inside in-situ preparation nano silver.
(6) step (5) is shown that PVC ureter washs, then dried；
Wherein washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 90~110 DEG C, drying time 25~
45min。
(7) to step (6), treated that PVC ureter sterilized, is packed.
Wherein sterilizing is ethylene oxide sterilizing, and sterilization time is 40~50min, the PVC ureter vacuum sealing after sterilizing
Packaging, and transport storage at normal temperature.
A kind of super hydrophilic antibacterial ureter based on amino nano silver molecular brush manufactured in the present embodiment, PVC ureter packet
Ontology and hydrophilic antimicrobial layer are included, hydrophilic antimicrobial layer is the nanometer silver coating of in-situ preparation polymer overmold；Ontology and hydrophilic antimicrobial
Intersect embedded combination between layer, forms a substance binder course, hydrophilic antimicrobial layer can form positively charged with water molecules
The hydration shell of lotus prevents bacterium and protein adherence tube wall in urine, has excellent wearability, durability and has no drug resistance.
Embodiment 1-4 utilizes oxidative grafting technique that grafted by super branched polymer to urine output pipe surface, is utilized hyperbranched poly
The superpower hydrophilic ability of object is closed, forms one layer of positively charged hydration shell on surface.Utilize electrostatic repulsion and steric hindrance
Effect prevents bacterium and protein from seeking connections with.On the other hand former in polymer cavity inside by the reproducibility of dissaving polymer
Position generates nano silver, and the killing bacteria that urine output pipe surface is resident once in a while can also be achieved active antibacterial by discharging silver ion, real
Now cooperate with multistage anti-infectious function.
Referring to GB/T20944.3-2008《The evaluation third portion of antibacterial textile performance：Succusion》, the present invention is implemented
Antibiotic fabric prepared by example 1-4 carries out Staphylococcus aureus (ATCC8099), Escherichia coli (ATCC 6538) carry out antibacterial survey
Examination.Test result is shown in Table 1：
Table 1
Above it is preferred section Example of the invention, the above conventional substitution or can be realized identical function
Embodiment is changed without departing from the principles and spirit of the present invention, is modified, is replaced, is integrated and parameter modification is equal
It falls within the scope of protection of the present invention.
Claims (10)
1. a kind of preparation method of the super hydrophilic antibacterial ureter based on amino nano silver molecular brush, which is characterized in that this method
Include the following steps：
(1) PVC ureter is added in the sulfuric acid solution of a certain concentration potassium permanganate, carries out acidification；
(2) by step (1), treated that PVC ureter is added in certain density dissaving polymer, in certain PH, temperature
Under the conditions of carry out graft reaction, obtain amination modification PVC ureter；
(3) the PVC ureter for obtaining step (2) immerses in ethanol solution, the processing of polymer scopiformization；
(4) step (3) is shown that PVC ureter washs；
(5) the PVC ureter that step (4) obtains is impregnated into AgNO3In solution；
(6) step (5) is shown that PVC ureter washs, then dried；
(7) to step (6), treated that PVC ureter sterilized, is packed.
2. the preparation method of the super hydrophilic antibacterial ureter according to claim 1 based on amino nano silver molecular brush,
It is characterized in that, potassium permanganate concentration is 30~60% in the step (1), and mass volume ratio is 0.1~1g/L, and sulfuric acid is standard
Concentrated sulfuric acid reagent, concentration 95~98%.
3. the preparation method of the super hydrophilic antibacterial ureter according to claim 1 based on amino nano silver molecular brush,
It is characterized in that, souring temperature is 30~45 DEG C in the step (1), and acidificatoin time is 1~300min.
4. the preparation of the super hydrophilic antibacterial ureter according to claim 1-3 based on amino nano silver molecular brush
Method, which is characterized in that dissaving polymer is amino fluidized polymer in the step (2), and the amino fluidized polymer is end
Amino ultrabranching polyamide or end carboxyl super branched polyamide, concentration are 0.01~10g/L.
5. the preparation of the super hydrophilic antibacterial ureter according to claim 1-3 based on amino nano silver molecular brush
Method, which is characterized in that in the step (2) pH value be 5~11, temperature be 50~98 DEG C, the graft reaction time be 15~
120min。
6. the preparation of the super hydrophilic antibacterial ureter according to claim 1-3 based on amino nano silver molecular brush
Method, which is characterized in that the ethanol solution in the step (3) is straight alcohol solution, and the straight alcohol solution dip time is
10~120min, so that polymer scopiform.
7. the preparation of the super hydrophilic antibacterial ureter according to claim 1-3 based on amino nano silver molecular brush
Method, which is characterized in that washing solution is distilled water in the step (4)；AgNO in the step (5)3Solution concentration is
0.078~0.39g/L, dip time are 10~60min.
8. the preparation of the super hydrophilic antibacterial ureter according to claim 1-3 based on amino nano silver molecular brush
Method, which is characterized in that step (6) the washing solution is distilled water, and drying equipment is baking oven, and drying temperature is 80~120
DEG C, 10~60min of drying time；Sterilizing in step (7) is ethylene oxide sterilizing, and sterilization time is 30~60min.
9. preparation method is obtained described in a kind of any one of -7 claims according to claim 1 is based on amino nano silver molecular brush
Super hydrophilic antibacterial ureter, which is characterized in that PVC ureter includes ontology and hydrophilic antimicrobial layer, and the hydrophilic antimicrobial layer is
The antibiotic property of the nanometer silver coating of in-situ preparation polymer overmold, prepared super hydrophilic antibacterial ureter is up to 99% or more.
10. the super hydrophilic antibacterial ureter according to claim 9 based on amino nano silver molecular brush, which is characterized in that
Intersect embedded combination between the ontology and hydrophilic antimicrobial layer, form a substance binder course, hydrophilic antimicrobial layer can be with water
Molecule combine form positively charged hydration shell, prevent bacterium and protein adherence tube wall in urine, have excellent wearability,
It durability and has no drug resistance.
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