CN1088075A - Cardiac potential comprehensive detecting method and detector thereof - Google Patents
Cardiac potential comprehensive detecting method and detector thereof Download PDFInfo
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- CN1088075A CN1088075A CN 93120921 CN93120921A CN1088075A CN 1088075 A CN1088075 A CN 1088075A CN 93120921 CN93120921 CN 93120921 CN 93120921 A CN93120921 A CN 93120921A CN 1088075 A CN1088075 A CN 1088075A
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Abstract
The invention discloses a kind of cardiac potential comprehensive detection method and comprehensive detector thereof.This method can be gathered the heartbeat ripple simultaneously under hypoxia, hyperoxia and home, the force value of beating and electrocardiogram, carries out comprehensive relative analysis then.Detector of the present invention mainly comprises high and low oxygen environment generator, exert pressure variator, cardiac potential comprehensive detector outward, and wherein the cardiac potential comprehensive detector partly is made up of heartbeat ripple part and electrocardiogram.This detector circuit safety, reliable, cost is low, noise is low, distortion is little, the baseline non-migration does not drift about, and can provide heart blood pressure variation diagram under different load, figure such as electrocardio comparison diagram and the compensatory changes in contrast of heart.
Description
The present invention relates to a kind of cardiac potential comprehensive detection method and detector thereof, relate in particular to a kind ofly under hypoxia, hyperoxia and home, gather heartbeat ripple, method and the instrument that load value and electrocardiosignal carry out comprehensive relative analysis of exerting pressure outward simultaneously.
At present, method and instrument that noinvasive detects heart disease have electrocardiogram, exercise electrocardiogram, ultrasoundcardiogram, phonocardiogram, sphygomanometer, X-ray film, CT, pulse instrument, cardiac catheterization, angiography and nuclear magnetic resonance check etc., yet these methods do not have dynamic load and change, only depend on the method for motion to increase cardiac load, the standard that neither one is horizontal, can not in time make the contrast of increase cardiac load front and back and many people's contrast, for the rich blood situation of heart, do not associate with the pressure of executing outward blood vessel yet.Coronarography, though be a kind of reliable detection method, but complicated operation, dangerous big, after morbidity, check for general, can not be as the means of early stage inspection, therefore, these methods and instrument, for early stage coronary heart disease, coronary artery disease, compensation go down, hypertension, arteriosclerotic inspection sensitivity is not high, alternative is not strong.
The object of the present invention is to provide a kind of method that cardiovascular diseasess such as coronary heart disease, sclerosis of blood vessels are checked in early days, this method is safe and reliable, dynamically observes the overall process of blood pressure, blood flow variation under the situation about can exert pressure outside changing.
Another object of the present invention is to provide a kind of heart comprehensive detector, this instrument is under the condition that the input pressure value changes, and the baseline of the ripple of beating output is skew thereupon not, and its temperature drift amount reduces, the degree of stability height.
Another purpose of the present invention is to provide a kind of power saving, noise is low, cost is low, distortion is little heart comprehensive detector.
As everyone knows, the oxygen consumption of human body is directly proportional with the quantity of motion of human body, and quantity of motion is directly proportional with the blood volume of fighting of heart, and the blood volume of fighting is pressed into direct ratio with blood vessel wall.Because blood is to human body delivering oxygen and nutrient, takes away the transmission liquid of carbon dioxide, so when hypoxia, heart strengthens acting, impel blood flow to increase, during hyperoxia, can reduce the heart acting, impel blood flow to reduce, the blood vessel wall pressure also changes thereupon.
According to the above-mentioned fact, it is as follows to implement method step of the present invention:
(1) in being lower than air under the environment of oxygen content, oxygen content is below 15%, blood vessel to be applied certain pressure, and the human heart load is increased, detect also record heart compensatory capacity and in external circulating system and Electrocardiographic situation of change;
(2) in being higher than air under the environment of oxygen content, oxygen content is more than 25%, and blood vessel is applied institute's plus-pressure in the same step (1), and cardiac load is reduced, and detects also record cardiac cycle system and Electrocardiographic situation of change;
(3) under the environment of normal oxygen content (21%), blood vessel is applied pressure in the same step (1), detect also record cardiac cycle system and Electrocardiographic situation of change;
(4) by pick off respectively with under above-mentioned three kinds of environment, the variable quantity that records by normal, hypoxia, hyperoxia, normal sequential circulation is transformed into analog electrical signal;
(5) convert above-said current signal to digital signal, the comprehensive classification of utilization relative analysis differential method, handle by microprocessor, then can obtain under different load heartbeat ripple, outside exert pressure and Electrocardiographic comprehensive color classification with the changing trend diagram and the compensatory changes in contrast figure of heart of heartbeat mean pressure, systolic pressure and diastolic pressure blood flow before and after baseline comparison diagram, colored subregion displayed map (contain 12 and lead electrocardiogram), the load variations.
Checkout equipment of the present invention comprises normal, high and low oxygen environment generator, exert pressure variator, cardiac potential comprehensive detector and pico computer and show print member etc. outward.Wherein the cardiac potential comprehensive detector partly is made up of dynamic (dynamical) heartbeat ripple part of the dirty electric current of thought-read and the bioelectric electrocardiogram of survey, with the heartbeat ripple after pick off is transformed into the signal of telecommunication, transmit with mode of frequency regulation, then through a split circuit, the flip-flop of the waveform of beating is separated, and in the end one-level is used electric capacity shunting coupling, thereby can further isolate, reduce the temperature drift amount, improve degree of stability.The pressure composition of being told by split circuit and the wavelength-division of beating are not sent to analog digital (A/D) changer after amplifying, handled by pico computer after being transformed into digital signal.
Electrocardiogram part comprises that mainly EGC sensor, 12 leads automatic switching circuit and electrocardio output circuit (I) and electrocardio output circuit (II); EGC sensor and 12 lead automatic switching circuit and common electrocardiograph similar; but electrocardio output circuit (I) is identical two-way with (II); handle 6 guiding paths and electrocardiosignal respectively; the feature of this circuit is to have adopted the common mode subtraction amplifier stage that is made of a high input impedance operational amplifier; the bleeder circuit that its dc power supply terminal has parallel resistance electric capacity and parallel resistance electric capacity to constitute; mid point string one resistance of bleeder circuit is as the signal ground end; separate with actual ground wire; two inputs of operational amplifier ratio that respectively is connected to is amplified resistance and is connected to the varistor that three voltage stabilizings, two inspection pipe butt joints form respectively; form star voltage-limiting protection circuit; not being higher than 220 volts of high voltages by the external world in order to holding circuit destroys; also protect simultaneously human body to avoid the high voltage influence; behind the output termination one frequency modulation optocoupler of operational amplifier; be connected to the capacitive reactance dividing potential drop coupling circuit of forming by two electrolysis condenser; after 50Hz trap circuit and the output of low pass narrow-band amplifier are delivered to pico computer analysis by analog digital (A/D) changer then.
Adopt method of the present invention dynamically to observe the overall process that the blood pressure blood flow changes, thereby can detect the variation of heart kinetic energy comprehensively, exactly from many-sides such as hemodynamics, Elasticity, hydrodynamics, electrobiologies.
Checkout equipment of the present invention partly has a splitter circuit at the heartbeat ripple of cardiac potential comprehensive detector, by the phase-locked integrated circuit of a low frequency, the capacitance resistance low pass filter, electrochemical capacitor shunt circuit and amplifying circuit are formed, electrochemical capacitor shunt circuit wherein links through an inducer and capacitance resistance low pass filter, the flip-flop of the waveform of beating can be separated, thereby under the condition that input pressure changes, the not skew thereupon of the ripple of beating output baseline, improved the accuracy that detects, in the end one-level adopts electric capacity shunting coupling, therefore can reduce the temperature drift amount, improve degree of stability, and can realize overlapping contrast.In addition, electrocardiogram at comprehensive detector partly has the identical electrocardio output circuit of two-way as mentioned above, they are connected in parallel to each other, handle 6 guiding path electrocardiosignaies respectively, therefore capacitive reactance influences the problem of output amplitude in the time of solving AC coupled satisfactorily, has overcome the shortcoming of existing electrocardiograph needle position misalignment and drift.
Each electrocardio output circuit of the present invention is a common mode subtraction amplifier stage that is made of high input impedance operational amplifier, the bleeder circuit that its dc power supply terminal has parallel resistance electric capacity and is made of parallel resistance electric capacity, the mid point of bleeder circuit is the signal ground end, separate with actual ground wire, two inputs of operational amplifier ratio that respectively is connected to is amplified resistance and is connected to the varistor that three Zener diode butt joints form respectively, the outfan of operational amplifier is connected to the capacitive reactance dividing potential drop coupling circuit of being made up of electrolysis condenser on two, exports analog digital converter to through 50Hz trap circuit and low pass amplifying circuit then.
Another feature of the present invention is that full machine adopts the centrally connected power supply power supply; to the power supply circuits of electrocardiogram part, transformer isolation and frequency modulation type light-coupled isolation technology are arranged; the signal ground of direct current supply is to be picked out with resistance by string on the dividing point of resistance capacitance divider in the above-mentioned electrocardio output circuit, and the input of operational amplifier is connected to the star voltage-limiting protection circuit that is formed by three Zener diode butt joints.
Advantage such as in a word, equipment of the present invention has that distortion is little, noise is low, circuit is simple, power saving, cost are low, safe and reliable.
The present invention is further described below in conjunction with drawings and Examples.
Fig. 1 is the sequential chart of hypoxia, hyperoxia and home detection method;
Fig. 2 is the formation block diagram of cardiac potential comprehensive detector;
Fig. 3 is the split circuit figure in one embodiment of the present of invention;
Fig. 4 is the heart circuit diagram in one embodiment of the present of invention.
Fig. 1 has illustrated the detection sequential of hypoxia, hyperoxia and home, begins 29 seconds, and high and low oxygen environment generator provides normal oxygen content 21% environment; after the detection, be separated by for 3 seconds, oxygen content for example is reduced to 10.5%; detection through 29 seconds so for example repeats 3 times, each 29 seconds; 3 seconds at interval, for example then oxygen content is brought up to more than 35%, detect again 3 times; each 29 seconds; 3 seconds at interval, after oxygen content is returned to normal value 21%, detect once again.These 8 testing results are all stored, are analyzed and compared by computer.Above-mentioned oxygen content and time length only are the data of an embodiment, and in the practical application, numerical value can change slightly, does not influence scope of the present invention.
In Fig. 2, heartbeat involves electrocardiosignal respectively by sensor acquisition, the ripple signal of beating adopts the frequency modulation transmission with capacity of resisting disturbance, enter split circuit, tell the DC component and the wave component of beating of energy representative pressure size, (the A/D changer is sent into pico computer then and is handled, and shows and printing to deliver to analog digital respectively after amplifying.Electrocardiosignal enters 12 and leads automatic switching circuit, the principle of this circuit is identical with general CF type electrocardiograph, divide two-way then, enter electrocardio output circuit (I) and electrocardio output circuit (II) respectively, this two paths of signals is after amplifying, also all send into analog digital (A/D) changer, change into digital signal and send into the pico computer processing again.Pico computer involves electrocardiogram with the heartbeat under low-oxygen environment, oxygen environment and the home comprehensively to be analyzed, and then the result is shown and prints.
In Fig. 3, enter low frequency phase-locked IC by input A through capacitor C1 and resistance R 0 through the heartbeat ripple signal of frequency modulation transmission and carry out demodulation, the II type low-pass filtering of forming via capacitor C6 resistance R 6 and R7 and C7 then, remove the high order high fdrequency component, export the B end to from the force value amplifier behind the passing point then, another road waveshape signal of beating is then delivered to the electric capacity shunting coupling circuit of being made up of electrolysis condenser C4 and C5 through inductance L 1, again through the twt amplifier of beating by the output of C end.This split circuit, both isolated DC potential, the characteristic that has kept the low frequency bandwidth again, it not only can be used as the amplifying circuit of low frequency, also solved owing to the difference that cardiovascular circulation is exerted pressure outward causes the different problem of baseline, thereby be implemented under the situation of input average voltage level variation, the baseline of heartbeat ripple output is skew thereupon, has created condition for realizing correlated method.
Fig. 4 a part of circuit of electrocardio output circuit (I) among Fig. 2 embodiment or (II) that drawn; 220 volts of alternating current power supplys are through rectification and overvoltage protection; output direct current V+, V-and 18V direct current, V+; V-supplies with other circuit; the 18V direct current is transformed into the 12V direct current and supplies with 12 wire guide networks after inverter and transformer isolation, owing to adopt transformer isolation and inverter and frequency modulation photoelectric coupled circuit; make 220 volts to 1500 volts interchanges can not scurry into 12 wire guide network parts, guaranteed personal safety.12 wire guide networks are used for detecting heart to human limb conduction electrocardio size, direction and time phase; cooperate with Rw1 and Rw2 through resistance R 18; Rw1 and Rw2 are varistors; it is the butt joint of three 10V left and right sides Zener diodes in fact respectively; make well and exist on the line under the above alternative situation of 220V; voltage difference between circuit also is no more than the Zener diode voltage of voltage regulation; thereby play the safeguard protection effect; resistance R 12,, R13, R14, R15 and W2 control ratio amplify, and impedance isolation and safeguard protection effect are also arranged.At the V+12V feeder ear, C9, R9 in parallel and C10, R10 in parallel form bleeder circuit, become the single power supply mode, get its mid point as signal ground, make signal ground and certain impedance are arranged on the spot, import the pressure-limit current-limit circuit in addition, play safe metering function.Again because the isolation of power supply just becomes earthing mode.Only use one-level operational amplifier A MP in the circuit, adopt high input impedance common mode subtraction mode, with the inconsistent problem of the parameter of avoiding a plurality of operational amplifiers to bring, improved fidelity, amplifier out adopts C14 and C15 capacitive reactance dividing potential drop coupled modes behind optocoupler, overcome existing electrocardiograph needle position misalignment and drifting problem, exported analog digital (A/D) changer through 50Hz trap circuit and low pass narrow-band amplifier at outfan D end then.
Claims (8)
1, a kind of cardiac potential comprehensive detection method, its step comprises:
(1) in being lower than air, under the environment of oxygen content, blood vessel is applied certain pressure, the human heart load is increased, external circulating system and Electrocardiographic situation of change in detection and record heart compensatory capacity reach;
(2) in being higher than air under the environment of oxygen content, cardiac load is reduced, blood vessel is applied pressure in the same step (1), detect also record cardiac cycle system and Electrocardiographic situation of change;
(3) under the environment of normal oxygen content (21%), blood vessel is applied pressure in the same step (1), detect also record cardiac cycle system and Electrocardiographic situation of change;
(4) by pick off respectively with under above-mentioned three kinds of environment, the variable quantity that records by normal, hypoxia, hyperoxia, normal sequential circulation is transformed into the simulation signal of telecommunication;
(5) convert above-said current signal to digital signal, the comprehensive classification of utilization relative analysis differential method, handle by microprocessor, thus obtain under different load heartbeat ripple, outside exert pressure and Electrocardiographic comprehensive color classification with the changing trend diagram and the compensatory changes in contrast figure of heart of the blood flow of heartbeat mean pressure, systolic pressure and diastolic pressure before and after baseline comparison diagram, colored subregion displayed map, the load variations.
2, the method for claim 1 is characterized in that containing the aerobic amount in the step (1) is below 15%.
3, the method for claim 1 is characterized in that oxygen content is more than 25% in the step (2).
4, a kind of cardiac potential comprehensive detector, comprise height, the low-oxygen environment generator, the variator of exerting pressure outward, the cardiac potential comprehensive detector, pico computer, show and print member, it is characterized in that above-mentioned cardiac potential comprehensive detector partly is made up of heartbeat part and electrocardiogram, beat pressure wave after pick off is transformed into the signal of telecommunication, be divided into the pressure composition and the ripple of beating through a split circuit, they are sent to the A/D changer respectively after amplifying, be transfused to pico computer after being transformed into digital signal, deliver to 12 by the signal of EGC sensor input and lead automatic switching circuit, send into the electrocardio output circuit then, send into pico computer through the A/D changer again.
5, require 4 described detectors as power, it is characterized in that above-mentioned split circuit is made up of the phase-locked integrated circuit of a low frequency, capacitance resistance low pass filter, electrochemical capacitor shunt circuit and amplifying circuit, electrochemical capacitor wherein, shunt circuit link through an inducer and capacitance resistance low pass filter.
6, detector as claimed in claim 4 is characterized in that above-mentioned electrocardio output circuit is identical two-way, and they are connected in parallel to each other, and handle 6 guiding path electrocardiosignaies respectively.
7, detector as claimed in claim 6, it is characterized in that each electrocardio output circuit is a common mode subtraction amplifier stage that is made of high input impedance operational amplifier, the bleeder circuit that its dc power supply terminal has parallel resistance electric capacity and is made of parallel resistance electric capacity, the mid point of bleeder circuit is the signal ground end, separate with actual ground wire, two inputs of operational amplifier ratio that respectively is connected to is amplified resistance and is connected to the varistor that three Zener diode butt joints form respectively, the outfan of operational amplifier is connected to the capacitive reactance dividing potential drop coupling circuit of being made up of two electrolysis condenser, exports analog digital converter to through 50Hz trap circuit and low pass amplifying circuit then.
8, according to claim 4 or 6 or 7 described cardiac potential comprehensive detectors; it is characterized in that: full machine adopts the centrally connected power supply power supply; to the power supply circuits of electrocardiogram part, transformer isolation and frequency modulation type light-coupled isolation technology are arranged; the signal ground of direct current supply is to be picked out with resistance by string on the dividing point of resistance capacitance divider in the above-mentioned electrocardio output circuit, and the input of operational amplifier is connected to the star voltage-limiting protection circuit that is formed by three Zener diode butt joints.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93120921 CN1045529C (en) | 1993-12-20 | 1993-12-20 | Cardiac potential comprehensive detecting method and detector thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 93120921 CN1045529C (en) | 1993-12-20 | 1993-12-20 | Cardiac potential comprehensive detecting method and detector thereof |
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| CN1088075A true CN1088075A (en) | 1994-06-22 |
| CN1045529C CN1045529C (en) | 1999-10-13 |
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| CN 93120921 Expired - Fee Related CN1045529C (en) | 1993-12-20 | 1993-12-20 | Cardiac potential comprehensive detecting method and detector thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102088899B (en) * | 2008-07-11 | 2013-03-06 | 国立大学法人筑波大学 | Blood vessel characteristics measurement device and method for measuring blood vessel characteristics |
| CN104349711A (en) * | 2012-04-23 | 2015-02-11 | 图尔库大学 | Method and apparatus for determining information indicative of cardiac malfunctions and abnormalities |
| CN105536207A (en) * | 2015-09-28 | 2016-05-04 | 首都医科大学宣武医院 | Pre-adaptive training method based on high-low oxygen combination |
| CN105534491A (en) * | 2015-09-28 | 2016-05-04 | 首都医科大学宣武医院 | Pre-adaptation training system based on high-low oxygen combination |
-
1993
- 1993-12-20 CN CN 93120921 patent/CN1045529C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102088899B (en) * | 2008-07-11 | 2013-03-06 | 国立大学法人筑波大学 | Blood vessel characteristics measurement device and method for measuring blood vessel characteristics |
| CN104349711A (en) * | 2012-04-23 | 2015-02-11 | 图尔库大学 | Method and apparatus for determining information indicative of cardiac malfunctions and abnormalities |
| US9585580B2 (en) | 2012-04-23 | 2017-03-07 | Turun Yliopisto | Method and apparatus for determining information indicative of cardiac malfunctions and abnormalities |
| CN105536207A (en) * | 2015-09-28 | 2016-05-04 | 首都医科大学宣武医院 | Pre-adaptive training method based on high-low oxygen combination |
| CN105534491A (en) * | 2015-09-28 | 2016-05-04 | 首都医科大学宣武医院 | Pre-adaptation training system based on high-low oxygen combination |
| CN105536207B (en) * | 2015-09-28 | 2017-03-15 | 首都医科大学宣武医院 | Pre-adaptive training method based on high-low oxygen combination |
| CN105534491B (en) * | 2015-09-28 | 2017-04-26 | 首都医科大学宣武医院 | Pre-adaptation training system based on high-low oxygen combination |
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| Publication number | Publication date |
|---|---|
| CN1045529C (en) | 1999-10-13 |
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