CN108794370A - A kind of preparation method for drawing sieve to replace Buddhist nun's intermediate - Google Patents
A kind of preparation method for drawing sieve to replace Buddhist nun's intermediate Download PDFInfo
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- CN108794370A CN108794370A CN201810855192.2A CN201810855192A CN108794370A CN 108794370 A CN108794370 A CN 108794370A CN 201810855192 A CN201810855192 A CN 201810855192A CN 108794370 A CN108794370 A CN 108794370A
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- buddhist nun
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- 0 N*CCC(c1cc(N)ccc1N)=O Chemical compound N*CCC(c1cc(N)ccc1N)=O 0.000 description 2
- QIZHVCUPPAMGIW-UHFFFAOYSA-N Fc(cc1)cc(C2=NCCC2)c1F Chemical compound Fc(cc1)cc(C2=NCCC2)c1F QIZHVCUPPAMGIW-UHFFFAOYSA-N 0.000 description 1
- XPESHHMXRZMUJT-UHFFFAOYSA-N O=C(CCCCCl)c1cc(F)ccc1F Chemical compound O=C(CCCCCl)c1cc(F)ccc1F XPESHHMXRZMUJT-UHFFFAOYSA-N 0.000 description 1
- MCKOYDSNCWNCHG-UHFFFAOYSA-N O=C(CCCCl)c1cc(F)ccc1F Chemical compound O=C(CCCCl)c1cc(F)ccc1F MCKOYDSNCWNCHG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Abstract
The invention discloses the preparation methods that a kind of drawing sieve replaces Buddhist nun's intermediate, and drawing sieve is type I compound for Buddhist nun's intermediate, and the preparation method includes step a or step b~c in following synthetic route：
Description
Technical field
The present invention relates to the preparation methods that a kind of drawing sieve replaces Buddhist nun's intermediate, belong to technical field of medicine synthesis.
Background technology
Larotrectinib (Chinese name draws sieve to replace Buddhist nun) is a kind of potent, oral, selective tropomyosin receptor kinase
(TRK) inhibitor, the product of the genetic abnormality occurred when one of TRK genes and other genes in cancer cell merge.
Larotrectinib is developed by Array BioPharma companies, and clinical research is carried out by Loxo Oncology.June 4 in 2017
Day, the clinical test results of larotrectinib, examination are disclosed in annual American Society of Clinical Oncology (ASCO) annual meeting
Result is tested to show：In the clinical test of 17 kinds of different type late tumor patients (including children and adult), use
76% patient reaches alleviation after larotrectinib treatments, and the alleviation of larotrectinib is more lasting, is starting to control
79% patient is alleviated sustainable 12 months after treatment.Currently, larotrectinib is expected to become first by " basket " clinic
Test (basket trial) granted targeted drug.The particular chemical formula of larotrectinib is as follows：
5- (2,5- difluorophenyl) -3,4- dihydro-2 h-pyrroles, No. CAS is：1443623-92-4, molecular formula are：
C10H9F2N, molecular weight are：181.18 chemical structural formula is：
The compound is to synthesize the important intermediate of larotrectinib.
It is reported at present about the synthesis of 5- (2,5- difluorophenyl) -3,4- dihydro-2 h-pyrroles, is mainly the following conjunction
At route：
1) the synthesis road of 5- disclosed in patent WO2009140128A2 (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles
Line：
With 2,5- difluorophenyl magnesium chlorides, for raw material, 5- (2,5- difluorobenzenes are prepared by two-step reaction in the route
Base) -3,4- dihydro-2 h-pyrroles, it not only needs to be reacted in a low temperature of -78 DEG C, it is also necessary to use expensive grignard
Reagent 2,5- difluorophenyl magnesium chlorides, severe reaction conditions are with high costs, therefore the synthetic route is not suitable for industrialized production.
2) (2,5- the difluorophenyls)-3,4- dihydros of 5- disclosed in patent US20160137654 and US20170281632-2H-
The synthetic route of pyrroles：
The route is using the bromo- Isosorbide-5-Nitrae-difluorobenzenes of 2- as raw material, by two steps synthesis 5- (2,5- difluorophenyl) -3,4- dihydros -
2H- pyrroles, but be also required in preparation process using expensive Grignard Reagent isopropylmagnesium chloride, severe reaction conditions,
It is with high costs, therefore the synthetic route is also not suitable for industrialized production.
Invention content
In view of the above-mentioned problems existing in the prior art, it is mild, at low cost that the object of the present invention is to provide a kind of reaction conditions
Honest and clean drawing sieve replaces Buddhist nun's intermediate (i.e.：5- (2,5- difluorophenyl) -3,4- dihydro-2 h-pyrroles) preparation method, to meet in this
Mesosome and drawing sieve replace the industrial production demand of Buddhist nun.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of preparation method for drawing sieve to replace Buddhist nun's intermediate, drawing sieve is type I compound for Buddhist nun's intermediate, including is closed as follows
At the step a or step b~c in route：
Preferably, the step a is by II compound of formula (the i.e. chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1-
Ketone) with nitrogen compound occur cyclisation type I compound (i.e. 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles) is obtained by the reaction.
As further preferred scheme, in step a, the nitrogen compound is NH3Or (the NH containing ammonium ion4 +) chemical combination
Object (such as：NH4Cl、NH4OAc、(NH4)2SO4)。
As further preferred scheme, II compound of formula：The molar ratio of nitrogen compound is 1：(1~10).
Preferably, the step b is by II compound of formula (the i.e. chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1-
Ketone) it reacts to obtain III compound of formula (i.e. 4- nitrine -1- (2,5- difluorophenyls) butyl- 1- ketone) with Sodium azide.
As further preferred scheme, II compound of formula：The molar ratio of Sodium azide or azidotrimethylsilane is 1:1~
2:3。
Preferably, the step c is by III compound of formula and reducing agent to carry out that type I compound is obtained by the reaction
(i.e. 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles).
As further preferred scheme, the step c is reacted in the presence of water with triphenylphosphine by III compound of formula
Obtain type I compound.
As still more preferably scheme, the step c is mixed what water and organic solvent were formed by III compound of formula
Type I compound is obtained by the reaction with triphenylphosphine in bonding solvent system.
As still more preferably scheme, the organic solvent is ether solvent, such as：Tetrahydrofuran, dioxane,
T-butyl methyl ether etc., organic solvent：The volume ratio of water is (3~10):1.
As still more preferably scheme, III compound of formula:The molar ratio of triphenylphosphine is 1:1~1:2.
Preferably, II compound of formula is by IV compound of formula (i.e. to difluorobenzene) in Louis acid catalysis
Lower to be obtained by the reaction with 4- chlorobutanoylchlorides generation friedel-craft, reaction equation is as follows：
With cheap and easy to get to difluoro benzene raw materials, it is only necessary to single step reaction, you can II compound of formula is made, it is easy to operate, it is at low cost
It is honest and clean, it is easy to large-scale production.
As further preferred scheme, the lewis acid is any one in alchlor, zinc chloride, iron chloride
Kind.
As further preferred scheme, IV compound of formula：Lewis acidic molar ratio is 1:1~1:3.
As further preferred scheme, IV compound of formula：The molar ratio of 4- chlorobutanoylchlorides is 1:1~2:3.
Compared with prior art, the present invention has following conspicuousness advantageous effect：
The present invention, for raw material, is passed through with II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone) cheap and easy to get
Simple one-step or two-step reaction can be prepared by required drawing sieve and replace Buddhist nun's intermediate：5- (2,5- difluorophenyls) -3,4- dihydros -
2H- pyrroles, entire route is easy to operate, and production cost is low, reaction condition is mild, is suitble to large-scale production, draws sieve to replace to realizing
The industrialization of Buddhist nun has extremely strong practical value, has conspicuousness progress compared with the existing technology.
Specific implementation mode
Technical solution of the present invention is described in further detail and completely with reference to embodiment.
Embodiment 1：
When lewis acid is alchlor, the system of II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone)
It is standby：
IV compound of formula (to difluorobenzene, 10g, 87.65mmol) and chlorobutanoylchloride (12.3g, 1.0eq) are dissolved in dichloromethane
In alkane (100mL), at 15~20 DEG C, aluminum trichloride (anhydrous) (14.02g, 105.18mmol) is added portionwise, after charging,
Room temperature reaction 12 hours, reaction was completed, adds water (50mL) that reaction is quenched, and gained mixed solution is extracted with ethyl acetate, is associated with
Machine phase, organic phase are dried with anhydrous sodium sulfate, and filtering, filtrate decompression is concentrated into no solution and distillates, residue silica gel column chromatography
Purifying is to get II compound of formula (11g, yield 57%).
Embodiment 2：
When lewis acid is zinc chloride, the preparation of II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone)：
IV compound of formula (to difluorobenzene, 10g, 87.65mmol) and chlorobutanoylchloride (12.3g, 1.0eq) are dissolved in dichloromethane
In alkane (100mL), at 15~20 DEG C, anhydrous zinc chloride (14.33g, 105.18mmol), after charging, room is added portionwise
Temperature reaction 12 hours, reaction was completed, adds water (50mL) that reaction is quenched, and gained mixed solution is extracted with ethyl acetate, and merges organic
Phase, organic phase are dried with anhydrous sodium sulfate, and filtering, filtrate decompression is concentrated into no solution and distillates, and residue silica gel column chromatography is pure
Change to get II compound of formula (9.3g, yield 49%).
Embodiment 3：
When lewis acid is iron chloride, the preparation of II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone)：
IV compound of formula (to difluorobenzene, 10g, 87.65mmol) and chlorobutanoylchloride (12.3g, 1.0eq) are dissolved in dichloromethane
In alkane (100mL), at 15~20 DEG C, anhydrous ferric chloride (17.06g, 105.18mmol), after charging, room is added portionwise
Temperature reaction 12 hours, reaction was completed, adds water (50mL) that reaction is quenched, and gained mixed solution is extracted with ethyl acetate, and merges organic
Phase, organic phase are dried with anhydrous sodium sulfate, and filtering, filtrate decompression is concentrated into no solution and distillates, and residue silica gel column chromatography is pure
Change to get II compound of formula (8g, yield 41%).
Embodiment 4：
The preparation of III compound of formula (4- nitrine -1- (2,5- difluorophenyls) butyl- 1- ketone)：
II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone, 1g, 4.57mmol) is dissolved in DMF (10mL)
In, NaN is added3(0.327g, 5.03mmol) after charging, reacts 12 hours, reaction was completed, to reaction solution at 30 DEG C
Middle addition 10mL water, there is solid precipitation under stirring, collect the solid of precipitation, dry to get III compound of formula, products therefrom is not necessarily to
Purifying is directly reacted in next step.
Embodiment 5：
When III compound of formula (4- nitrine -1- (2,5- difluorophenyl) butyl- 1- ketone) is reactant, type I compound is drawn
Sieve replaces Buddhist nun's intermediate：The preparation of 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles：
III compound of formula made from embodiment 4 (4- nitrine -1- (2,5- difluorophenyls) butyl- 1- ketone) is dissolved in tetrahydrofuran
Triphenylphosphine (1.22g, 4.66mmol), after charging, room temperature is added in the in the mixed solvent of (8mL) and water (2mL) at room temperature
Reaction 8 hours, reaction was completed, and reaction solution is extracted with ethyl acetate, and merges organic phase, and organic phase is dried with anhydrous sodium sulfate, mistake
Filter, filtrate decompression concentration is to get type I compound (700mg, two steps add up to yield 84%).
Embodiment 6：
When II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone) is reactant, nitrogen compound NH4When Cl,
Type I compound draws sieve to replace Buddhist nun's intermediate：The preparation of 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles：
II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone, 1g, 4.57mmol) is dissolved in MeOH (20mL)
In, NH is added at room temperature4Cl (1.22g, 22.8mmol), after charging, back flow reaction 8 hours, reaction was completed, and reaction solution is used
Ethyl acetate extracts, and merges organic phase, and organic phase is dried with anhydrous sodium sulfate, filters, and filtrate decompression concentrates to get I chemical combination of formula
Object (500mg, yield 60%).
Embodiment 7：
When II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone) is reactant, nitrogen compound NH4OAc
When, type I compound draws sieve to replace Buddhist nun's intermediate：The preparation of 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles：
II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone, 1g, 4.57mmol) is dissolved in MeOH (20mL)
In, NH is added at room temperature4OAc (1.76g, 22.8mmol), after charging, back flow reaction 8 hours, reaction was completed, reaction solution
It is extracted with ethyl acetate, merges organic phase, organic phase is dried with anhydrous sodium sulfate, is filtered, and filtrate decompression concentration is changed to get formula I
Close object (550mg, yield 66%).
Embodiment 8：
When II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone) is reactant, nitrogen compound NH3When, formula
I compound draws sieve to replace Buddhist nun's intermediate：The preparation of 5- (2,5- difluorophenyls) -3,4- dihydro-2 h-pyrroles：
II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone, 1g, 4.57mmol) is dissolved in the THF containing ammonia
In (6M, 20mL), tank reaction 8 hours is covered at 50~60 DEG C, reaction was completed, and reaction solution is concentrated under reduced pressure to get type I compound
(550mg, yield 66%).
In conclusion the present invention with II compound of formula (the chloro- 1- of 4- (2,5- difluorophenyl) butyl- 1- ketone) be raw material, it is only necessary to
One-step or two-step reaction can be prepared by that sieve is drawn to replace Buddhist nun's intermediate：5- (2,5- difluorophenyl) -3,4- dihydro-2 h-pyrroles has behaviour
Make the advantages that simple, production cost is low, reaction condition is mild, to realizing 5- (2,5- difluorophenyl) -3,4- dihydro-2 h-pyrroles
There is extremely strong practical value with the industrialization for drawing sieve to replace Buddhist nun, there is conspicuousness progress compared with the existing technology.
Finally need indicated herein be：The part preferred embodiment that the above is only the present invention, should not be understood as to this hair
The limitation of bright protection domain, those skilled in the art's the above according to the present invention make some it is nonessential improvement and
Adjustment all belongs to the scope of protection of the present invention.
Claims (8)
1. a kind of preparation method for drawing sieve to replace Buddhist nun's intermediate, drawing sieve is type I compound for Buddhist nun's intermediate, which is characterized in that
The preparation method includes step a or step b~c in following synthetic route：
2. preparation method according to claim 1, it is characterised in that：The step a is by II compound of formula and nitridation
It closes object generation cyclisation and type I compound is obtained by the reaction.
3. preparation method according to claim 2, it is characterised in that：In step a, the nitrogen compound is NH3Or contain ammonium
The compound of radical ion.
4. preparation method according to claim 1, it is characterised in that：The step b is by II compound of formula and nitrine
Sodium or azidotrimethylsilane react to obtain III compound of formula.
5. preparation method according to claim 1, it is characterised in that：The step c is by III compound of formula and reduction
Agent carries out that type I compound is obtained by the reaction.
6. preparation method according to claim 5, it is characterised in that：The step c is deposited in water by III compound of formula
Type I compound is obtained by the reaction with triphenylphosphine lower.
7. preparation method according to claim 1, it is characterised in that：II compound of formula is existed by IV compound of formula
Friedel-craft occurs with 4- chlorobutanoylchlorides under Louis acid catalysis to be obtained by the reaction, reaction equation is as follows：
8. preparation method according to claim 6, it is characterised in that：The lewis acid be selected from alchlor, zinc chloride,
Any one in iron chloride.
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Cited By (6)
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| CN108484361A (en) * | 2018-05-11 | 2018-09-04 | 上海弈柯莱生物医药科技有限公司 | (S) the chloro- 1- of -4- (2,5)-difluorophenyl butyl- 1- alcohol and its preparation method and application |
| CN110283858A (en) * | 2019-07-05 | 2019-09-27 | 尚科生物医药（上海）有限公司 | The method that biocatalysis prepares (S) -2- (2,5- difluorophenyl) pyrrolidines |
| CN111333561A (en) * | 2020-04-30 | 2020-06-26 | 安徽德信佳生物医药有限公司 | Synthetic method of ralotinib intermediate (2R) -2- (2, 5-difluorophenyl) pyrrolidine |
| CN111393347A (en) * | 2020-04-30 | 2020-07-10 | 安徽德信佳生物医药有限公司 | Synthetic method of ralotinib intermediate |
| CN111793016A (en) * | 2020-08-10 | 2020-10-20 | 钟桂发 | Preparation method of larotinib intermediate and intermediate compound |
| CN114163445A (en) * | 2021-12-06 | 2022-03-11 | 重庆医科大学 | Raatinib intermediate and preparation method thereof |
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|---|---|---|---|---|
| CN108484361A (en) * | 2018-05-11 | 2018-09-04 | 上海弈柯莱生物医药科技有限公司 | (S) the chloro- 1- of -4- (2,5)-difluorophenyl butyl- 1- alcohol and its preparation method and application |
| CN108484361B (en) * | 2018-05-11 | 2022-09-30 | 弈柯莱生物科技(上海)股份有限公司 | (S) -4-chloro-1- (2,5) -difluorophenylbutan-1-ol and preparation method and application thereof |
| CN110283858A (en) * | 2019-07-05 | 2019-09-27 | 尚科生物医药（上海）有限公司 | The method that biocatalysis prepares (S) -2- (2,5- difluorophenyl) pyrrolidines |
| CN110283858B (en) * | 2019-07-05 | 2024-01-26 | 尚科生物医药（上海）有限公司 | Method for preparing (S) -2- (2, 5-difluorophenyl) pyrrolidine by biocatalysis |
| CN111333561A (en) * | 2020-04-30 | 2020-06-26 | 安徽德信佳生物医药有限公司 | Synthetic method of ralotinib intermediate (2R) -2- (2, 5-difluorophenyl) pyrrolidine |
| CN111393347A (en) * | 2020-04-30 | 2020-07-10 | 安徽德信佳生物医药有限公司 | Synthetic method of ralotinib intermediate |
| CN111793016A (en) * | 2020-08-10 | 2020-10-20 | 钟桂发 | Preparation method of larotinib intermediate and intermediate compound |
| CN111793016B (en) * | 2020-08-10 | 2024-03-26 | 钟桂发 | Preparation method of larotinib intermediate and intermediate compound |
| CN114163445A (en) * | 2021-12-06 | 2022-03-11 | 重庆医科大学 | Raatinib intermediate and preparation method thereof |
| CN114163445B (en) * | 2021-12-06 | 2023-06-20 | 重庆医科大学 | Larotinib intermediate and preparation method thereof |
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