CN108785252A - A kind of curcumin nano breast and preparation method thereof - Google Patents
A kind of curcumin nano breast and preparation method thereof Download PDFInfo
- Publication number
- CN108785252A CN108785252A CN201710286111.7A CN201710286111A CN108785252A CN 108785252 A CN108785252 A CN 108785252A CN 201710286111 A CN201710286111 A CN 201710286111A CN 108785252 A CN108785252 A CN 108785252A
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- Prior art keywords
- curcumin
- curcumin nano
- nano breast
- breast
- preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
Abstract
The present invention relates to a kind of curcumin nano breasts and preparation method thereof, and wherein curcumin nano breast includes following components 1-20% curcumins, 5-15% surfactants and 2-3% thickeners, and the preparation of curcumin nano breast comprises the steps of：(1) active constituent, surfactant are added into reaction kettle, the rotating speed of stirring at normal temperature, stirring is that 50-80 turns/min, stirs 1.5-2h, is sufficiently mixed；(2) gained mixture in step (1) is ultrasonically treated, thickener is added, stirs to obtain ginger-colored nano-emulsion.
Description
Technical field
The present invention relates to a kind of chemicals field, more particularly to a kind of curcumin nano breast and its preparation.
Background technology
Curcumin is a kind of phenolic compound extracted from zingiberaceous plant turmeric, have it is anti-oxidant, antitumor, anti-inflammatory,
The effects that anti HIV-1 virus, reducing blood lipid, antiatherosclerosis.However, curcumin poorly water-soluble, it is difficult to absorb in body, easily
Metabolism (oral administration biaavailability is low, most of to be excreted with original shape), it is light sensitive, degradable, to limit its clinic
Using.In recent years, the research of curcumin is become more and more active, as the insoluble drug for having applications well foreground, passes through dosage form
Developmental research improve its bioavilability, extend action time, it has also become the heat subject studied now.
Nano-emulsion has the following advantages and is concerned：1. being isotropic transparency liquid, belong to Thermodynamically stable system,
It can not be allowed to be layered through pressure sterilizing or centrifugation；2. simple for process, preparation process is not required to special installation, can spontaneously form, receive
Rice milk grain size is generally 1~100nm；3. viscosity is low, pain when injection can be reduced；4. with sustained release and targeting；5. carrying
The solubility of high active ingredient.Curcumin is thus prepared into nano-emulsion, the solubility of curcumin can be increased and reduce illumination etc.
Cause the degradation of curcumin.
Invention content
Goal of the invention：A kind of curcumin nano breast of present invention offer and preparation method thereof, can greatly improve curcumin
Stability.
Technical solution：Curcumin nano breast of the present invention, mainly made by the raw material by following mass percent：1-
20% curcumin, 5-15% surfactants and 2-3% thickeners.
The surfactant is selected from lecithin, alkyl phenol polyoxyethylene ether, Tween 80, high-carbon fatty alcohol polyoxyethylene ether
In it is one or more.
The thickener is selected from gelatin, casein sodium, agar, sodium alginate, pectin, xanthans, cycloheptaamylose, carboxylic
It is one or more in sodium carboxymethylcellulose pyce.
Curcumin nano breast of the present invention, grain size 10-100nm.
The preparation method of curcumin nano breast, comprises the steps of：(1) curcumin, surface-active are added into reaction kettle
The rotating speed of agent, stirring at normal temperature, stirring is that 50-80 turns/min, stirs 1.5-2h, is sufficiently mixed；(2) gained in step (1) is mixed
It closes object to be ultrasonically treated, thickener is then added, mix, obtain curcumin nano breast.
It is 300W, supersonic frequency 20KHZ, ultrasonic time 30min that supersound process, which is ultrasonic power,.
Curcumin nano breast of the present invention can be used for antitumor medical food.
Inventive principle：The present invention can form the surface-active of stable nano-emulsion system using screening very well with curcumin
Agent is prepared for curcumin nano breast.
Advantageous effect：Nano-emulsion is because its grain size is smaller, large specific surface area, can greatly improve the absorption effect of curcumin
Rate, in addition nano-emulsion curcumin can be isolated with external environment, greatly reduce influence of the external environment to curcumin stability,
Greatly improve the stability of curcumin.
Specific implementation mode
One, embodiment is prepared
Embodiment 1：Curcumin, lecithin are added into reaction kettle, the rotating speed of stirring at normal temperature, stirring is that 50-80 turns/min,
1.5-2h is stirred, is sufficiently mixed, is then ultrasonically treated, it is 300W to be ultrasonically treated as ultrasonic power, and supersonic frequency is
Then gelatin is added in 20KHZ, ultrasonic time 30min, mixing, and it is 1% curcumin, 5% lecithin and 2% gelatin to obtain content
The curcumin nano breast of composition.
Embodiment 2：Curcumin nano breast group is divided into 5% curcumin, 10% alkyl phenol polyoxyethylene ether and 3% caseinic acid
Sodium, remaining is the same as embodiment 1.
Embodiment 3：Curcumin nano breast group is divided into 10% curcumin, 15% Tween 80 and 3% agar, remaining same embodiment
1。
Embodiment 4：Curcumin nano breast group is divided into 15% curcumin, 10% high-carbon fatty alcohol polyoxyethylene ether and 2% sea
Mosanom, remaining is the same as embodiment 1.
Embodiment 5：Curcumin nano breast group is divided into 20% curcumin, 10% alkyl phenol polyoxyethylene ether and 3% pectin,
Remaining same embodiment 1.
Embodiment 6：It is fine that curcumin nano breast group is divided into 15% curcumin, 5% alkyl phenol polyoxyethylene ether and 2% carboxymethyl
The plain sodium of dimension, remaining is the same as embodiment 1.
Comparative example 1：Curcumin is dissolved in ethanol solution, obtains 15% curcumin ethanol solution.
Two, result detects
In ultraviolet ray intensity it is 70 μ w/cm by prepared embodiment 1-6 and comparative example 12For 24 hours, detection is each for lower irradiation
The degradation rate of curcumin, the results are shown in Table 1 in embodiment.
As can be seen from Table 1, the curcumin nano breast that prepared by the present invention can greatly improve ginger-colored photodissociation rate.
1 sample curcumin degradation rate of table
Claims (7)
1. a kind of curcumin nano breast, mainly made by the raw material by following mass percent：1-20% curcumins, 5-15% tables
Face activating agent and 2-3% thickeners.
2. curcumin nano breast according to claim 1, it is characterised in that the surfactant is selected from lecithin, alkyl phenol
It is one or more in polyoxyethylene ether, Tween 80, high-carbon fatty alcohol polyoxyethylene ether.
3. according to claim 1 curcumin nano breast, it is characterised in that the thickener be selected from gelatin, casein sodium,
It is one or more in agar, sodium alginate, pectin, xanthans, cycloheptaamylose, sodium carboxymethylcellulose.
4. curcumin nano breast according to claim 1, it is characterised in that the grain size of the nano-emulsion is 10-100nm.
5. according to the preparation method of any curcumin nano breast described in claim 1-4, comprise the steps of：
(1) active constituent, surfactant are added into reaction kettle, the rotating speed of stirring at normal temperature, stirring is that 50-80 turns/min, is stirred
1.5-2h is mixed, is sufficiently mixed；
(2) gained mixture in step (1) is ultrasonically treated, thickener is then added, mixes, obtain curcumin nano breast.
6. the preparation method of ginger color nano-emulsion according to claim 5, it is characterised in that in step (2), the ultrasound
It is 300W, supersonic frequency 20KHZ, ultrasonic time 30min that processing, which is ultrasonic power,.
7. being used for antitumor medical food according to any curcumin nano breast described in claim 1-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710286111.7A CN108785252A (en) | 2017-04-27 | 2017-04-27 | A kind of curcumin nano breast and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710286111.7A CN108785252A (en) | 2017-04-27 | 2017-04-27 | A kind of curcumin nano breast and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN108785252A true CN108785252A (en) | 2018-11-13 |
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| CN201710286111.7A Pending CN108785252A (en) | 2017-04-27 | 2017-04-27 | A kind of curcumin nano breast and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200833A (en) * | 2019-06-03 | 2019-09-06 | 五邑大学 | A kind of phloretin nano-emulsion preparation and its preparation method and application |
| CN113908126A (en) * | 2021-11-22 | 2022-01-11 | 东莞中芝生物科技有限公司 | Ganoderma lucidum spore oil nanoemulsion and preparation method thereof |
| CN117159445A (en) * | 2023-01-28 | 2023-12-05 | 济宁医学院 | Preparation method and application of curcumin nanoemulsion temperature-sensitive hydrogel |
-
2017
- 2017-04-27 CN CN201710286111.7A patent/CN108785252A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200833A (en) * | 2019-06-03 | 2019-09-06 | 五邑大学 | A kind of phloretin nano-emulsion preparation and its preparation method and application |
| CN113908126A (en) * | 2021-11-22 | 2022-01-11 | 东莞中芝生物科技有限公司 | Ganoderma lucidum spore oil nanoemulsion and preparation method thereof |
| CN117159445A (en) * | 2023-01-28 | 2023-12-05 | 济宁医学院 | Preparation method and application of curcumin nanoemulsion temperature-sensitive hydrogel |
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| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181113 |
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| WD01 | Invention patent application deemed withdrawn after publication |