CN108785199A - A kind of protective agent and preparation method thereof preventing nail fracture - Google Patents
A kind of protective agent and preparation method thereof preventing nail fracture Download PDFInfo
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- CN108785199A CN108785199A CN201810707523.8A CN201810707523A CN108785199A CN 108785199 A CN108785199 A CN 108785199A CN 201810707523 A CN201810707523 A CN 201810707523A CN 108785199 A CN108785199 A CN 108785199A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to chemical reagent technical fields, provide a kind of protective agent and preparation method thereof preventing nail fracture, the reason of fracture in conjunction with nail, pointedly have developed the protective agent of the present invention.The protective agent is by nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, Tween 80, sodium alginate, dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth factor, guanidine peptide, film forming agent and deionized water; it is composed according to certain proportioning; the peculiar characteristic of above-mentioned each ingredient has been given full play to, and a complete technical solution for solving nail fracture is formd by mutual synergistic effect.Experimental results show that protective agent of the invention can effectively prevent nail to be broken, and promote the healthy growth of nail, keep the intensity of nail and ruddy degree.
Description
Technical field
The invention belongs to chemical reagent technical fields, and in particular, to a kind of protective agent and its system preventing nail fracture
Preparation Method.
Background technology
There are many unguis hominis fragile in daily life, and more crisp, easily snaps off.It is serious to have influenced nail
There are many health and good appearance, the reason of inducing this phenomenon, if do not paid attention to the diet of oneself, protein and calcium in diet, sulphur,
The elements such as zinc, iron or vitamin A, B, C are insufficient, and nail is caused to lack nutrition;Environment influences, the overlong time that nail is contacted with water;
Chronic disease or mood are in stress situation etc..But on how to prevent the breakage problem of nail, there is presently no relatively effectively
Method, research it is also less.
Therefore, it in order to overcome the above problem, needs to research and develop a kind of protective agent and preparation method thereof preventing nail fracture.
Invention content
For the defects in the prior art, the object of the present invention is to provide a kind of protective agent for preventing nail to be broken and preparations
Method.
A kind of protective agent for preventing nail to be broken provided according to an aspect of the present invention, described prevents the guarantor that nail is broken
Shield agent includes the raw material of following parts by weight:11-18 parts of nano-attapulgite, 3-15 parts of methacrylic acid, vinyl hydroxy silicon
21-25 parts oily, 3-9 parts of Tween 80,5-13 parts of sodium alginate, 11-16 parts of dendrobium candidum extract, Gotu Kola P.E 13-27
Part, 12-19 parts of violet cabbage extract, 3-11 parts of basic fibroblast growth factor, 13-19 parts of guanidine peptide, film forming agent 1.4-2.8
Part, 20-37 parts of deionized water;
The protectant preparation method for preventing nail to be broken is as follows:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
30-40 DEG C, 15-20min is kept the temperature, is cooled to 20-25 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10-15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 10-15min, filter, and discharge, and stand, you can.
Preferably, the extracting method of the dendrobium candidum extract is specific as follows:
(1)Dendrobium candidum is pulverized, be sieved 20-30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 60-75% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, reflux
Degreasing 1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 95 DEG C, water-bath refluxing extraction 60min,
Filtered after being cooled to room temperature, discard residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in
4000r/min centrifuges 15-20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2-3 times, and centrifugation discards supernatant
Liquid obtains material, then by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, the extracting method of the Gotu Kola P.E is specific as follows:
(1)Centella is pulverized, be sieved 10-30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 65-70% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, reflux
Degreasing 1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 90 DEG C, water-bath refluxing extraction 60min,
Filtered after being cooled to room temperature, discard residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in
4000r/min centrifuges 15-20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2-3 times, and centrifugation discards supernatant
Liquid obtains material, then by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, vitamin combination is adhered on the nano-attapulgite surface.
Preferably, the method for the nano-attapulgite surface attachment vitamin combination is specific as follows:
(1)Vitamin combination is coupled to the surface of nano-attapulgite by amide bond chemistry;
(2)There is the nano-attapulgite surface of vitamin combination to coat titanium oxide shell in coupling in such a way that silicon source hydrolyzes,
Form nucleocapsid composite Nano Functional attapulgite particle;
(3)To the nucleocapsid composite Nano Functional attapulgite particle surface using polyethylene glycol in the method chemical modification of reflux, and
Polyethylene glycol and the molar ratio of nucleocapsid composite Nano Functional attapulgite particle are 5: 1;
(4)Nucleocapsid composite Nano Functional attapulgite particle through chemical modification polyethylene glycol is etched using inorganic lye, formation has
Multi-pore canal nuclear shell composite Nano Functional attapulgite particle.
Compared with prior art, the present invention has following advantageous effect:
1, the reason of present invention provides a kind of protective agent for preventing nail to be broken, and present invention combination nail is broken, pointedly grinds
The protective agent of the present invention is made.The protective agent is by nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, Tween 80, sea
Mosanom, dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth factor, guanidine peptide,
Film forming agent and deionized water are composed according to certain proportioning, have given full play to the peculiar characteristic of above-mentioned each ingredient, and
A complete technical solution for solving nail fracture is formd by mutual synergistic effect.Experimental results are aobvious
Show, protective agent of the invention can effectively prevent nail to be broken, and promote the healthy growth of nail, keep the intensity of nail and ruddy
Degree.
2, the present invention provides a kind of protective agent for preventing nail to be broken, and the present invention protects the nano-attapulgite in agent prescription
Possess abundant specific surface area, physicochemical property stabilization, there is adsorption sustained-release effect to harmful substances such as VOC in protective agent, reduce
Nail is to the absorption of harmful substance and harmful substance is avoided to spill into air, reduces environmental pollution.Again because of present invention protection
Nano-attapulgite in agent is inorganic particle, to prevent nano-attapulgite from precipitation of reuniting occurring in protective agent, therefore is added
Enter dispersion stabilizer of the Tween 80 as nano-attapulgite, protective agent precipitation is avoided to reunite.The present invention protects in agent prescription
Sodium alginate:It with anti-corrosion function, can prevent protective agent corruption from going mouldy, be used for a long time;Ability with film forming and very strong
The effect of protecting colloid can make protective agent stay longer on nail, protect nail, nail is prevented to be broken.
3, the present invention provides a kind of protective agent for preventing nail to be broken, and the present invention protects the vinyl hydroxy silicon in agent prescription
Oil is with silicon-oxygen(Si-O)Key is the vinyl hydroxy polysiloxanes emulsion of backbone structure, can improve protection in formula
The physical mechanical properties such as the mobility of agent and tear resistance enhance protectant physical property, promote quality.
4, the present invention provides a kind of protective agent for preventing nail to be broken, and the present invention protects the centella centella in agent prescription
Extract can compact nail, and skin is made to limber up, and help the formation for promoting collagen in nail, enhance the tough of nail
Degree also assists in impaired nail tissue healing, ensures that nail is healthily grown.
With moistening effect, good, lasting moisturizing, reparation are damaged nail tissue to dendrobium candidum extract, ensure that nail is strong
Health.
Basic fibroblast growth factor is one and transmits development signal, can promote fissional polypeptide.In vitro,
It can stimulate cellular proliferation, migrate, induce activator of plasminogen and collagenase activity, promote the growth and update of nail tissue,
Quickly repair impaired nail tissue.
5, the present invention provides a kind of protective agent for preventing nail to be broken, and nano-attapulgite surface of the invention is attached with dimension
Raw promotor composition, the ingredient of vitamin combination can selectivity combination such as vitamin A, E;Vitamin A, E, B etc., according to finger
The nutritional deficiency situation progress of first is reasonably combined, to promote the growth of nail.Vitamin combination is attached to nano-attapulgite
Native surface can more be evenly distributed in nail surface, be absorbed and utilized for nail.
During vitamin combination is adhered on nano-attapulgite surface, surface silica dioxide Shell Materials are deposited
It is multi-pore channel structure in, titanium oxide surface shell, the internal vitamin combination adhered to can be made slowly to release,
It is utilized evenly by nail.
6, the present invention provides a kind of protective agent for preventing nail to be broken, and primary solvent of the invention is deionized water, and VOC contains
It measures low, human body is not injured, have no irritating odor, does not have corrosivity, it is environmentally protective.
Specific implementation mode
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.
Embodiment 1
A kind of protective agent for preventing nail to be broken provided in this embodiment, the protective agent for preventing nail to be broken includes as follows
The raw material of parts by weight:18 parts of nano-attapulgite, 3 parts of methacrylic acid, 25 parts of vinyl hydroxy silicone oil, 3 parts of Tween 80,
13 parts of sodium alginate, 11 parts of dendrobium candidum extract, 27 parts of Gotu Kola P.E, 12 parts of violet cabbage extract, basic fibroblast
1 part of growth factor-21,13 parts of guanidine peptide, 2.8 parts of film forming agent, 20 parts of deionized water;
The protectant preparation method for preventing nail to be broken is as follows:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
40 DEG C, 15min is kept the temperature, is cooled to 25 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 15min, filter, and discharge, and stand, you can.
Preferably, the extracting method of the dendrobium candidum extract is specific as follows:
(1)Dendrobium candidum is pulverized, be sieved 30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 75% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 95 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2-3 times, and centrifugation discards supernatant liquid and obtains object
Material, then by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, the extracting method of the Gotu Kola P.E is specific as follows:
(1)Centella is pulverized, be sieved 30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 70% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 90 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2 times, and centrifugation discards supernatant liquid and obtains material,
Then it by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, vitamin combination is adhered on the nano-attapulgite surface.The ingredient of vitamin combination
Combination such as vitamin A, E that can be selective;Vitamin A, E, B etc., it is reasonably combined according to the progress of the nutritional deficiency situation of nail,
To promote the growth of nail.
Preferably, the method for the nano-attapulgite surface attachment vitamin combination is specific as follows:
(1)Vitamin combination is coupled to the surface of nano-attapulgite by amide bond chemistry;
(2)There is the nano-attapulgite surface of vitamin combination to coat titanium oxide shell in coupling in such a way that silicon source hydrolyzes,
Form nucleocapsid composite Nano Functional attapulgite particle;
(3)To the nucleocapsid composite Nano Functional attapulgite particle surface using polyethylene glycol in the method chemical modification of reflux, and
Polyethylene glycol and the molar ratio of nucleocapsid composite Nano Functional attapulgite particle are 5: 1;
(4)Nucleocapsid composite Nano Functional attapulgite particle through chemical modification polyethylene glycol is etched using inorganic lye, formation has
Multi-pore canal nuclear shell composite Nano Functional attapulgite particle.
Embodiment 2
A kind of protective agent for preventing nail to be broken provided in this embodiment, the protective agent for preventing nail to be broken includes as follows
The raw material of parts by weight:11 parts of nano-attapulgite, 15 parts of methacrylic acid, 21 parts of vinyl hydroxy silicone oil, 9 parts of Tween 80,
5 parts of sodium alginate, 16 parts of dendrobium candidum extract, 13 parts of Gotu Kola P.E, 19 parts of violet cabbage extract, basic fibroblast are thin
3 parts of the intracellular growth factor, 19 parts of guanidine peptide, 1.4 parts of film forming agent, 37 parts of deionized water;
The protectant preparation method for preventing nail to be broken is as follows:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
30 DEG C, 20min is kept the temperature, is cooled to 20 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 10min, filter, and discharge, and stand, you can.
Preferably, the extracting method of the dendrobium candidum extract is specific as follows:
(1)Dendrobium candidum is pulverized, be sieved 20 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 60% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 95 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 15min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 3 times, and centrifugation discards supernatant liquid and obtains material,
Then it by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, the extracting method of the Gotu Kola P.E is specific as follows:
(1)Centella is pulverized, be sieved 20 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 67% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 90 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 16min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 3 times, and centrifugation discards supernatant liquid and obtains material,
Then it by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, vitamin combination is adhered on the nano-attapulgite surface.The ingredient of vitamin combination
Combination such as vitamin A, E that can be selective;Vitamin A, E, B etc., it is reasonably combined according to the progress of the nutritional deficiency situation of nail,
To promote the growth of nail.
Preferably, the method for the nano-attapulgite surface attachment vitamin combination is specific as follows:
(1)Vitamin combination is coupled to the surface of nano-attapulgite by amide bond chemistry;
(2)There is the nano-attapulgite surface of vitamin combination to coat titanium oxide shell in coupling in such a way that silicon source hydrolyzes,
Form nucleocapsid composite Nano Functional attapulgite particle;
(3)To the nucleocapsid composite Nano Functional attapulgite particle surface using polyethylene glycol in the method chemical modification of reflux, and
Polyethylene glycol and the molar ratio of nucleocapsid composite Nano Functional attapulgite particle are 5: 1;
(4)Nucleocapsid composite Nano Functional attapulgite particle through chemical modification polyethylene glycol is etched using inorganic lye, formation has
Multi-pore canal nuclear shell composite Nano Functional attapulgite particle.
Embodiment 3
A kind of protective agent for preventing nail to be broken provided in this embodiment, the protective agent for preventing nail to be broken includes as follows
The raw material of parts by weight:15 parts of nano-attapulgite, 8 parts of methacrylic acid, 24 parts of vinyl hydroxy silicone oil, 5 parts of Tween 80,
7 parts of sodium alginate, 15 parts of dendrobium candidum extract, 17 parts of Gotu Kola P.E, 16 parts of violet cabbage extract, basic fibroblast are thin
4 parts of the intracellular growth factor, 18 parts of guanidine peptide, 1.7 parts of film forming agent, 25 parts of deionized water;
The protectant preparation method for preventing nail to be broken is as follows:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
35 DEG C, 17min is kept the temperature, is cooled to 22 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10-15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 12min, filter, and discharge, and stand, you can.
Preferably, the extracting method of the dendrobium candidum extract is specific as follows:
(1)Dendrobium candidum is pulverized, be sieved 27 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 62% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 95 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 16min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 3 times, and centrifugation discards supernatant liquid and obtains material,
Then it by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, the extracting method of the Gotu Kola P.E is specific as follows:
(1)Centella is pulverized, be sieved 19 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 68% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, flow back degreasing
1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 90 DEG C, water-bath refluxing extraction 60min, cooling
It is filtered after to room temperature, discards residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in 4000r/
Min centrifuges 17min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 3 times, and centrifugation discards supernatant liquid and obtains material,
Then it by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
Preferably, vitamin combination is adhered on the nano-attapulgite surface.The ingredient of vitamin combination
Combination such as vitamin A, E that can be selective;Vitamin A, E, B etc., it is reasonably combined according to the progress of the nutritional deficiency situation of nail,
To promote the growth of nail.
Preferably, the method for the nano-attapulgite surface attachment vitamin combination is specific as follows:
(1)Vitamin combination is coupled to the surface of nano-attapulgite by amide bond chemistry;
(2)There is the nano-attapulgite surface of vitamin combination to coat titanium oxide shell in coupling in such a way that silicon source hydrolyzes,
Form nucleocapsid composite Nano Functional attapulgite particle;
(3)To the nucleocapsid composite Nano Functional attapulgite particle surface using polyethylene glycol in the method chemical modification of reflux, and
Polyethylene glycol and the molar ratio of nucleocapsid composite Nano Functional attapulgite particle are 5: 1;
(4)Nucleocapsid composite Nano Functional attapulgite particle through chemical modification polyethylene glycol is etched using inorganic lye, formation has
Multi-pore canal nuclear shell composite Nano Functional attapulgite particle.
Embodiment 4
Experiment test:
Step 1: the material proportional quantity according to embodiment 1,2,3 prepares raw material,
Protective agent 1:18 parts of nano-attapulgite, 3 parts of methacrylic acid, 25 parts of vinyl hydroxy silicone oil, 3 parts of Tween 80, seaweed
13 parts of sour sodium, 11 parts of dendrobium candidum extract, 27 parts of Gotu Kola P.E, 12 parts of violet cabbage extract, basic fibroblast
11 parts of growth factor, 13 parts of guanidine peptide, 2.8 parts of film forming agent, 20 parts of deionized water;
Protective agent 2:11 parts of nano-attapulgite, 15 parts of methacrylic acid, 21 parts of vinyl hydroxy silicone oil, 9 parts of Tween 80, sea
5 parts of mosanom, 16 parts of dendrobium candidum extract, 13 parts of Gotu Kola P.E, 19 parts of violet cabbage extract, basic fibroblast
3 parts of growth factor, 19 parts of guanidine peptide, 1.4 parts of film forming agent, 37 parts of deionized water;
Protective agent 3:15 parts of nano-attapulgite, 8 parts of methacrylic acid, 24 parts of vinyl hydroxy silicone oil, 5 parts of Tween 80, seaweed
7 parts of sour sodium, 15 parts of dendrobium candidum extract, 17 parts of Gotu Kola P.E, 16 parts of violet cabbage extract, basic fibroblast life
4 parts of the long factor, 18 parts of guanidine peptide, 1.7 parts of film forming agent, 25 parts of deionized water.
Step 2: protectant preparation method according to the invention,
Protective agent 1:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
40 DEG C, 15min is kept the temperature, is cooled to 25 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 15min, filter, and discharge, and stand, you can.
Protective agent 2:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
30 DEG C, 20min is kept the temperature, is cooled to 20 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 10min, filter, and discharge, and stand, you can.
Protective agent 3:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
35 DEG C, 17min is kept the temperature, is cooled to 22 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10-15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 12min, filter, and discharge, and stand, you can.
Step 3:
Protective agent 1,2,3 is prepared, the people for choosing the fracture of 8 nails is labeled as 1 group, 2 groups, 3 groups, 4 groups as experimental subjects,
1,2,3 equivalent of protective agent is applied on the nail of 1 group, 2 groups, 3 groups people one week by every group of 2 people respectively, and 4 groups are not smeared, as right
According to group, the situation of change of nail is observed, as a result such as following table:
Index | 1 group | 2 groups | 3 groups | 4 groups |
Fracture restoration degree | It is basic to repair | It repairs completely | It is basic to repair | It does not repair |
Nail colour | Color is ruddy | Color is ruddy | Color is ruddy | It is gloomy |
Nail hardness | It is hard | It is hard | It is hard | It is soft, thin |
It is shown by above-mentioned experimental result, protective agent prepared by the present invention has apparent reparation to the crack conditions of nail, improves and make
With, and nail healthy growth can be promoted, it is worthy of popularization.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring the substantive content of the present invention.
Claims (5)
1. a kind of protective agent for preventing nail to be broken, it is characterised in that:The protective agent for preventing nail to be broken includes as follows
The raw material of parts by weight:11-18 parts of nano-attapulgite, 21-25 parts of vinyl hydroxy silicone oil, is spat 3-15 parts of methacrylic acid
80 3-9 parts of temperature, 5-13 parts of sodium alginate, 11-16 parts of dendrobium candidum extract, 13-27 parts of Gotu Kola P.E, violet cabbage carry
Take 12-19 parts of object, 3-11 parts of basic fibroblast growth factor, 13-19 parts of guanidine peptide, 1.4-2.8 parts of film forming agent, deionized water
20-37 parts;
The protectant preparation method for preventing nail to be broken is as follows:
(1)Nano-attapulgite, methacrylic acid, vinyl hydroxy silicone oil, sodium alginate are added in stirring container, are warming up to
30-40 DEG C, 15-20min is kept the temperature, is cooled to 20-25 DEG C;
(2)To(1)Middle addition dendrobium candidum extract, Gotu Kola P.E, violet cabbage extract, basic fibroblast growth
The factor, guanidine peptide stir 10-15min, and material is made to be uniformly mixed;
(3)To(2)Middle addition Tween 80, film forming agent, deionized water stir 10-15min, filter, and discharge, and stand, you can.
2. a kind of protective agent for preventing nail to be broken according to claim 1, it is characterised in that:The dendrobium candidum extraction
The extracting method of object is specific as follows:
Dendrobium candidum is pulverized, be sieved 20-30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 60-75% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, reflux
Degreasing 1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 95 DEG C, water-bath refluxing extraction 60min,
Filtered after being cooled to room temperature, discard residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in
4000r/min centrifuges 15-20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2-3 times, and centrifugation discards supernatant
Liquid obtains material, then by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
3. a kind of protective agent for preventing nail to be broken according to claim 1, it is characterised in that:The Gotu Kola P.E
Extracting method it is specific as follows:
(1)Centella is pulverized, be sieved 10-30 mesh, obtains powder material;
(2)To(1)Powder material in mass fraction is added is 65-70% ethyl alcohol, be uniformly mixed, be heated to 70 DEG C, reflux
Degreasing 1.0h, discards residue, then dry material is uniformly mixed with water, is warming up to 90 DEG C, water-bath refluxing extraction 60min,
Filtered after being cooled to room temperature, discard residue and obtain material, be subsequently added into absolute ethyl alcohol, shake up, refrigeration is stood overnight, then in
4000r/min centrifuges 15-20min, discards supernatant liquid and obtains material, and finally plus absolute ethyl alcohol washs 2-3 times, and centrifugation discards supernatant
Liquid obtains material, then by dry materials, is cooled to room temperature to obtain dendrobium candidum extract.
4. a kind of protective agent for preventing nail to be broken according to claim 1, it is characterised in that:The nano-attapulgite
Vitamin combination is adhered on surface.
5. a kind of protective agent for preventing nail to be broken according to claim 4, it is characterised in that:The nano-attapulgite
The method that vitamin combination is adhered on surface is specific as follows:
(1)Vitamin combination is coupled to the surface of nano-attapulgite by amide bond chemistry;
(2)There is the nano-attapulgite surface of vitamin combination to coat titanium oxide shell in coupling in such a way that silicon source hydrolyzes,
Form nucleocapsid composite Nano Functional attapulgite particle;
(3)To the nucleocapsid composite Nano Functional attapulgite particle surface using polyethylene glycol in the method chemical modification of reflux, and
Polyethylene glycol and the molar ratio of nucleocapsid composite Nano Functional attapulgite particle are 5: 1;
(4)Nucleocapsid composite Nano Functional attapulgite particle through chemical modification polyethylene glycol is etched using inorganic lye, formation has
Multi-pore canal nuclear shell composite Nano Functional attapulgite particle.
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CN106309168A (en) * | 2016-10-21 | 2017-01-11 | 熊廷珍 | Full-nutrition type aqueous nail enamel |
CN106389157A (en) * | 2016-04-27 | 2017-02-15 | 金华市名仕科技股份有限公司 | Fingernail glaze |
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CN101693011A (en) * | 2009-08-13 | 2010-04-14 | 苏州纳米技术与纳米仿生研究所 | Preparation method of magnetic medicine-carrying nano-particle |
CN105250174A (en) * | 2015-10-27 | 2016-01-20 | 桂林瑞丰环保微生物应用研究所 | Health care nursing type nail polish and preparation method thereof |
CN105287251A (en) * | 2015-11-04 | 2016-02-03 | 上海应用技术学院 | Long-acting antioxidant water-based nail polish |
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