CN108783554A - A kind of leakage of efficient anti-seepage carries capsule with diuresis promoting function and preparation method thereof - Google Patents
A kind of leakage of efficient anti-seepage carries capsule with diuresis promoting function and preparation method thereof Download PDFInfo
- Publication number
- CN108783554A CN108783554A CN201810684856.3A CN201810684856A CN108783554A CN 108783554 A CN108783554 A CN 108783554A CN 201810684856 A CN201810684856 A CN 201810684856A CN 108783554 A CN108783554 A CN 108783554A
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- Prior art keywords
- capsule
- layer
- water
- water blocking
- blocking layer
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- 239000002775 capsule Substances 0.000 title claims abstract description 189
- 208000004880 Polyuria Diseases 0.000 title claims abstract description 44
- 230000035619 diuresis Effects 0.000 title claims abstract description 44
- 230000001737 promoting effect Effects 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 181
- 230000000903 blocking effect Effects 0.000 claims abstract description 109
- 206010011732 Cyst Diseases 0.000 claims abstract description 56
- 208000031513 cyst Diseases 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 43
- 230000035699 permeability Effects 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 6
- 229920001651 Cyanoacrylate Polymers 0.000 claims description 28
- 229920005989 resin Polymers 0.000 claims description 26
- 239000011347 resin Substances 0.000 claims description 26
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 claims description 25
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 21
- 239000006185 dispersion Substances 0.000 claims description 18
- 239000000178 monomer Substances 0.000 claims description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 12
- -1 esters compound Chemical class 0.000 claims description 9
- 238000005253 cladding Methods 0.000 claims description 8
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 7
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 7
- 229920002545 silicone oil Polymers 0.000 claims description 7
- 235000010443 alginic acid Nutrition 0.000 claims description 6
- 229920000615 alginic acid Polymers 0.000 claims description 6
- 239000003208 petroleum Substances 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 238000007711 solidification Methods 0.000 claims description 5
- 230000008023 solidification Effects 0.000 claims description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 239000001913 cellulose Chemical class 0.000 claims description 4
- 229920002678 cellulose Chemical class 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000000016 photochemical curing Methods 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 244000061176 Nicotiana tabacum Species 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000003860 storage Methods 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 3
- 229920002730 Poly(butyl cyanoacrylate) Polymers 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 213
- 235000010413 sodium alginate Nutrition 0.000 description 38
- 239000000661 sodium alginate Substances 0.000 description 38
- 229940005550 sodium alginate Drugs 0.000 description 38
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 37
- 239000011259 mixed solution Substances 0.000 description 29
- 239000002994 raw material Substances 0.000 description 27
- 239000000686 essence Substances 0.000 description 25
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 24
- 239000003999 initiator Substances 0.000 description 16
- 239000001110 calcium chloride Substances 0.000 description 14
- 229910001628 calcium chloride Inorganic materials 0.000 description 14
- 238000011017 operating method Methods 0.000 description 10
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 8
- 239000004568 cement Substances 0.000 description 8
- 239000001993 wax Substances 0.000 description 8
- 235000010410 calcium alginate Nutrition 0.000 description 7
- 239000000648 calcium alginate Substances 0.000 description 7
- 229960002681 calcium alginate Drugs 0.000 description 7
- 239000003292 glue Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000001112 coagulating effect Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 125000004093 cyano group Chemical group *C#N 0.000 description 5
- 239000006187 pill Substances 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 150000001336 alkenes Chemical class 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000013871 bee wax Nutrition 0.000 description 4
- 239000012166 beeswax Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241001474374 Blennius Species 0.000 description 3
- 235000008429 bread Nutrition 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000004203 carnauba wax Substances 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 239000011162 core material Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000001723 curing Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical group C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000016261 weight loss Diseases 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000004819 Drying adhesive Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 230000003487 anti-permeability effect Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011257 shell material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
- A24B3/12—Steaming, curing, or flavouring tobacco
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of efficient anti-seepages to leak load capsule with diuresis promoting function and preparation method thereof, capsule is at least three-decker, it is followed successively by sandwich layer, cyst wall layer, water blocking layer from inside to outside, water blocking layer coats cyst wall layer, its material is polybutylcyanoacrylate, 7 days permeability rates that efficient anti-seepage leakage carries capsule with diuresis promoting function are less than 4%, sphericity SF<0.07, capsule prepared by this method, ratio of briquetting is high, and smooth in appearance is mellow and full, uniform particle diameter, and the impermeable effect that blocks water is remarkable, and Storage period is long, and manufacturing process is easy, can be directly used for food, medicine and cigarette products processing.
Description
Technical field
The invention belongs to capsule preparation fields, and in particular to a kind of efficient anti-seepage leakage load capsule with diuresis promoting function.
Background technology
Get up water or aqueous soluble active constituent environmental sealing to form capsule using encapsulation techniques, keeps moisture in capsule
It is always the research hotspot and difficult point in the fields such as food, medicine, tobacco in transport phase and shelf life long-time storage ne-leakage.
The selection of capsule wall material determines the mechanical property and permeance property of capsule.Alginic acid calcium salt is food and glue,medicinal
Most common wall material in capsule, using ionic calcium soln as coagulating bath, the calcium alginate gel prepared using dropping preparation method has put into industry
Metaplasia produces and obtains commercialization and promotes.
The prior art is more to the calcium alginate gel report of cladding oil or oil-soluble active ingredient, and for carrying water seaweed
The report of sour calcium capsule is less.
Existing patent of invention, Publication No. CN102108136B, disclose a kind of dripping pills of cigarette additive lapping and
With the application of the dripping pill and dripping pill of its package, the dripping pill is specifically disclosed for cigarette field, capsule is made using positive drop method, it should
Capsule includes two layers, and sandwich layer and wrapping layer, lapping is by sodium alginate：Glycerine：Water is with (1-8)：(0.5-5)：(85-
100) ratio mixing composition, then capsule is made with the calcium ion solidification in coagulating bath.However, during we repeat to test
It was found that capsule-wall made from this method is very thin, do not have mechanical strength needed for follow-up industrial processes, practicability is poor.
Existing patent of invention, Publication No. CN103815541A disclose a kind of three layers of cigarette capsule with diuresis promoting function, and wherein internal layer is
Water, gelatin, preservative and essence, middle layer are sodium alginate, water, preservative, and outer layer is beeswax, paraffin and Brazil is cured is made.
The invention is in original calcium alginate gel outer layer covers blended wax, to preventing the moisture spilling in capsule from having certain effect, but
The interface binding power of the mixing wax layer of hydrophilic calcium alginate cyst wall layer and oleophylic is poor, wraps up uneven, cracky, and mix
Wax melting temperature is closed at 50 DEG C or so, is vulnerable to the influence of ambient temperature, state labile.These result in the invention capsule without
Method long-time storage, easy to leak.
Existing patent publication No. is CN103815542A on the basis of foregoing invention patent, discloses a kind of four layers of cigarette water
Capsule, that is, using sodium alginate as raw material, forms one layer of protection in the 4th layer of the external sheath of original three layers of cigarette capsule with diuresis promoting function
Film reduces the rupture of wax.However being still the problem of interface cohesion force difference between sodium alginate and wax coat influences the capsule
Infiltrative principal element leads to the third layer and the 4th layer of uneven, the cracky of package of four layers of capsule with diuresis promoting function, easily seeps water.
Existing publication number is that CN105361242A discloses a kind of quick-fried pearl of Mobyneb cigarette based on liquid hoodle
And preparation method thereof, existing publication number is that CN106914196A discloses one kind based on liquid hoodle preparation load water microcapsules
Method.Two patents are by elder generation in water drops surface coated by hydrophobic particle, then coat instant drying adhesive and light-cured resin successively
Water blocking layer realizes the preparation for the antiseep capsule that blocks water.However from the point of view of the effect for repeating experiment, by simply impregnating or
The method of coating coats water blocking layer, and capsule cyst membrane became uneven is even, seriously affects the appearance and block-water effect of capsule.
From the prior art, the technology of preparing scheme for currently existing the impermeable capsule that blocks water, is by capsule
One layer of water blocking layer is arranged in outer layer, prevents water or the aqueous solution extravasation of capsule internal layer, extends the validity period of capsule, but the prior art
Capsule shaping degree and block-water effect are unsatisfactory.
Invention content
For deficiency in the prior art, the purpose of the present invention is to provide a kind of efficient anti-seepage leak adhesive capsule and its preparation sides
Method.It solves capsule sandwich layer water or aqueous solution in the prior art easily to permeate, block-water effect is undesirable and forming degree is undesirable
Technical problem.
To achieve the goals above, it is leaked the present invention provides a kind of efficient anti-seepage and carries capsule with diuresis promoting function, it is characterised in that：Capsule is
At least three-decker, is followed successively by sandwich layer, cyst wall layer, the first water blocking layer from inside to outside, and first water blocking layer is coated on cyst wall layer
Outside, it is the polymerizate of one or more cyanoacrylate compounds, it is small that efficient anti-seepage leakage carries 7 days permeability rates of capsule with diuresis promoting function
In 4%, sphericity SF<0.07.
It is alginate, cellulose derivative, gelatin, chitosan, poly- second that efficient anti-seepage leakage, which carries capsule with diuresis promoting function cyst wall layer material,
It is one or more in glycol, polyvinyl alcohol.
It is water or load water component that efficient anti-seepage leakage, which carries capsule with diuresis promoting function sandwich layer,.
The alpha-cyanoacrylate ester structure is CH2=C (CN) COOR, wherein R are alkyl, aryl, the alkoxy of C1-16.
The cyanoacrylate is Methyl 2-cyanoacrylate, cyanacrylate, Tisuacryl, cyano third
At least one of olefin(e) acid monooctyl ester；
The cyanoacrylate that the present invention uses can be simple reagent, can also be the examination containing cyanoacrylate
Agent, as long as can reach the requirement that cyanoacrylate forms the first water blocking layer outside cyst wall layer, the present invention can select city
The product containing cyanoacrylate sold, such as Instant cement 502 or Instant cement 508.
The present invention selects to use cyanoacrylate compound as the first water blocking layer, cyanoacrylate compound
Structure be CH2=C (CN) COOR, wherein R are alkyl, aryl, the alkoxy of C1-16, due on a carbon atom of alkene
It is connected to-CN and-COOR so that β carbon atoms have strong suction electrical on alkene, the weak substance of compatibility are encountered, such as water, ammonia
Anionic polymerisation rapidly occurs for base, alcohol etc. so that double bond cloud density reduces, and generates the polymerisation of moment, liquid
Adhesive moment becomes solid-state.It is ingenious when preparation blocks water impermeable capsule for inventing the characteristic using cyanoacrylate
Using the substance as the first water blocking layer, acted on using cyanoacrylate and water micro on capsule layer so that cyano
Acrylate carries out polymerizing curable on micro-capsule surface layer, forms the first water blocking layer, and then reach the impermeable effect that blocks water.Permeability rate is adopted
It is tested with weight method, specifically randomly selects 50 capsules, weigh its weight at regular intervals, calculate its weight-loss ratio,
And be averaged, as a result reflect the impermeable effect of capsule, i.e. permeability rate, capsule prepared by the present invention 7 days it is permeable
Rate is less than 4%, preferably smaller than 3%, is further preferably no larger than 2%；30 days permeability rates are less than 8%, preferably smaller than 5%, into one
Step preferably smaller than 3%.
Capsule further includes the 4th layer, and the 4th layer is the second water blocking layer, and the second water blocking layer is coated on outside the first water blocking layer, and second
Water blocking layer is light-cured resin, and the first water blocking layer can be fixed in the second water blocking layer, and further decreases the saturating of capsule
Water rate.
According to the practical application of capsule, different core materials can be added, sandwich layer can be water, or aqueous group
Part.For a kind of solute containing metal ion, with cyst wall layer raw material, especially sodium alginate ion can occur for this kind of solute
It exchanges, obtains the cyst wall layer with cross-linked structure, and the sandwich layer for effectively wrapping up water or aqueous components forms ball-type capsule structure.
In order to prepare the capsule of the present invention, preparation method of the invention includes the following steps：(1) glue is prepared by dropping preparation method
Capsule, sandwich layer are water or aqueous components, and cyst wall layer is alginate, cellulose derivative, gelatin, chitosan, polyethylene glycol, poly- second
It is one or more in enol；(2) capsule surface coats the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2)
Aqueous capsule surface coats the second water blocking layer.
Efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, which is characterized in that the dropping preparation method is anti-drop method, when preparing capsule
Temperature be 50-80 DEG C.
Positive drop method and anti-drop method can prepare capsule, and positive drop method is that cyst material and core material are passed through coaxial double needle
Dropping feeder is added drop-wise in solidification solution, the positive capsule for dripping method and preparing, and the cross-linking reaction of cyst wall layer is from outer wall to sandwich layer side
To diffusion process.Anti- drop rule is that the sandwich layer solution for containing coagulating component is added drop-wise in cyst wall layer raw material, the anti-glue for dripping method and preparing
Capsule, the cross-linking reaction of cyst wall are sandwich layers to cyst wall layer diffusion process.Positive drop method is different with the anti-dropwise addition sequence of drop method, makes cyst wall
The curing degree of layer generates difference, and the capsule prepared using anti-drop method, size is easier to control, and wall thickness is big, Neng Goufang
The exudation of sealing point can also meet the requirement that following process in the process crushes capsule intensity.The capsule prepared with anti-drop method is straight
Diameter is 3+2mm.
Efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, which is characterized in that the method for the first water blocking layer of cladding is, by step
(1) in a solvent, the solvent and water are immiscible, and do not react with cyanoacrylate, and solvent is for gained capsules disperse
One or more of dimethyl carbonate, butyl acetate, chloroform, silicone oil, petroleum ether, toluene, n-hexane, atoleine,
Cyanoacrylate compound is added dropwise to above-mentioned dispersion, until capsule surface forms the first water blocking layer.
The selected solvent of step (1) of the present invention be dimethyl carbonate, butyl acetate, chloroform, silicone oil, petroleum ether,
One or more of toluene, n-hexane, atoleine, above-mentioned organic solvent and water are immiscible, not with cyanoacrylate
Class compound reacts.The capsule prepared by step (1), cyst wall main component are calcium alginate hydrogel, surface
Cyanoacrylate can be made to polymerize in conjunction with water, cyano is added dropwise in the dispersion of calcium alginate gel and organic solvent
After acrylate, cyanoacrylate spontaneous can adhere on cyst wall surface, and polymerisation occurs, and obtain the first water blocking layer；And
And used organic solvent and water are immiscible, then do not penetrate into capsule sandwich layer, in sandwich layer water or aqueous components cause
Pollution or undesirable influence.This method is different from that directly capsule being impregnated in covering material, or brushes, spray coating material
Material forms the conventional method of water blocking layer.Conventional method is compared it is found that this method can be evenly coated, the glue that blocks water of good sphericity
Capsule, improves the load water stability and effect of capsule, and largely reduces the dosage of the first water blocking layer raw material, very
Suitable for industrialized production.
Efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, which is characterized in that the method for the second water blocking layer of cladding is, by step
(2) in a solvent, which can not dissolve the first water blocking layer to gained capsules disperse, immiscible with light-cured resin and will not occur
Reaction, solvent are water, dimethyl carbonate, butyl acetate, chloroform, silicone oil, petroleum ether, toluene, n-hexane, atoleine one
Kind is several, light-cured resin monomer and initiator is added dropwise to above-mentioned dispersion while stirring, then cure using ultraviolet lighting
Coat the second water blocking layer.
The present invention does not do particular determination to the type of light-cured resin and initiator, including those skilled in the art can
It chooses, the photo-curing monomer not reacted with solvent, and the light-cured resin list of waterproof effect can be played after curing
Body and initiator.
It can also select commercially available light-cured resin monomer TTA21P and initiator UVI6976.
Solvent used by step (2) of the present invention is water, dimethyl carbonate, butyl acetate, chloroform, silicone oil, oil
Ether, toluene, n-hexane, atoleine are one or more of, and above-mentioned solvent will not dissolve the first water blocking layer, and it is solid not interfere with light
Change resin monomer polymerisation.This method is different from that directly capsule being added in light-cured resin to impregnate, or brushes, spraying
Light-cured resin forms the conventional method of water blocking layer.Conventional method is compared it is found that the smooth circle of capsule surface prepared by this method
Profit, is evenly coated, good sphericity, and the load water stability of capsule is high, and Storage period is long, and largely reduces second and block water
The dosage of layer raw material is conducive to industrialized production popularization.
Efficient anti-seepage leakage prepared by the present invention carries capsule with diuresis promoting function and can apply to food, medicine and Cigarette processing field.
The capsule being prepared using the method for the present invention, manufacturing process is easy, and ratio of briquetting is high, and uniform particle sizes are simultaneously easy control
System, block water impermeable excellent ability, there is longer Storage period, can be used for food, medicine and Cigarette processing field.
Description of the drawings
Fig. 1：Capsule structure schematic diagram
1：Sandwich layer；2：Cyst wall layer；3：First water blocking layer；4：Second water blocking layer
Fig. 2；Capsule microscope figure a, pure calcium alginate carry capsule with diuresis promoting function；B, the capsule prepared using the method for comparative example 3；C,
The capsule prepared using embodiment 6
Specific embodiment
Embodiment 1
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
Calcium chloride water, a concentration of 10%；Prepare cyst wall layer, cyst wall layer raw material be sodium alginate soln, a concentration of 3%；Prepare the
One water blocking layer, the first water blocking layer are cyanoacrylate.Operating procedure is that (1) prepares capsule by the anti-method of dripping, and sandwich layer is chlorination
Calcium aqueous solution, cyst wall layer raw material are sodium alginate soln；(2) capsules disperse obtained by step (1) is in dimethyl carbonate, to above-mentioned
Cyanoacrylate is added dropwise in dispersion, until capsule surface forms the first water blocking layer.In order to ensure alginic acid when preparing capsule
The mobility of sodium, temperature are controlled at 60 DEG C.
Embodiment 2
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Prepare sandwich layer, sandwich layer
For the mixed solution of water, essence and calcium chloride, essence a concentration of 20%, calcium chloride solution concentration 10%；Prepare cyst wall layer, capsule
Parietal layer raw material be sodium alginate soln, a concentration of 3%；The first water blocking layer is prepared, the first water blocking layer is cyanoacrylate；It prepares
Second water blocking layer, the second water blocking layer are the mixed solution of light-cured resin monomer and initiator.Operating procedure is that (1) is by anti-
Drop method prepares capsule, and sandwich layer is the mixed solution of water, essence and calcium chloride, and cyst wall layer raw material is sodium alginate soln；(2) capsule
Surface coats the first water blocking layer, and by capsules disperse obtained by step (1) in dimethyl carbonate, cyano is added dropwise to above-mentioned dispersion
Acrylate, until forming the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries capsule with diuresis promoting function surface and coats
Light-cured resin monomer is added dropwise in toluene, to above-mentioned dispersion in second water blocking layer, i.e., the capsules disperse obtained (2) step
With the mixed solution of initiator, it is stirred to react a period of time, until forming the second water blocking layer.In order to ensure seaweed when preparing capsule
The mobility of sour sodium, temperature are controlled at 60 DEG C.
Embodiment 3
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
The mixed solution of water, essence and calcium chloride, essence a concentration of 20%, calcium chloride solution concentration 10%；Prepare cyst wall layer, cyst wall
Layer raw material be sodium alginate soln, a concentration of 3%；The first water blocking layer is prepared, the first water blocking layer is cyanoacrylate；Prepare the
Two water blocking layers, the second water blocking layer are the mixed solution of light-cured resin monomer and initiator.Operating procedure is that (1) is dripped by counter
Method prepares capsule, and sandwich layer is the mixed solution of water, essence and calcium chloride, and cyst wall layer raw material is sodium alginate soln；(2) capsule table
Bread covers the first water blocking layer, and by capsules disperse obtained by step (1) in butyl acetate, cyanoacrylate is added dropwise to above-mentioned dispersion
Acid esters, until forming the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries capsule with diuresis promoting function surface cladding second
Light-cured resin monomer and initiation is added dropwise in water, to above-mentioned dispersion in water blocking layer, i.e., the capsules disperse obtained (2) step
The mixed solution of agent is stirred to react a period of time, until forming the second water blocking layer.In order to ensure sodium alginate when preparing capsule
Mobility, temperature are controlled at 60 DEG C.
Embodiment 4
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Prepare sandwich layer, sandwich layer
For the mixed solution of water, essence and calcium chloride, essence a concentration of 15%, calcium chloride solution concentration 10%；Prepare cyst wall layer
Solution, cyst wall layer raw material are sodium alginate soln, sodium alginate soln a concentration of 3%；Prepare the first water blocking layer, the first water blocking layer
For cyanoacrylate；The second water blocking layer is prepared, the second water blocking layer is the mixed solution of light-cured resin monomer and initiator.Behaviour
It is that (1) prepares capsule by the anti-method of dripping as step, sandwich layer is the mixed solution of water, essence and calcium chloride, and cyst wall layer raw material is sea
Solution of sodium alginate；(2) capsule surface coats the first water blocking layer, by step (1) gained capsules disperse in petroleum ether, to above-mentioned point
Cyanoacrylate is added dropwise in granular media system, until forming the first water blocking layer；(3) efficient anti-seepage being prepared in step (2), which leaks, carries
Capsule with diuresis promoting function surface coats the second water blocking layer, i.e., the capsules disperse obtained (2) step is dripped in n-hexane to above-mentioned dispersion
The mixed solution for adding light-cured resin monomer and initiator is stirred to react a period of time, until forming the second water blocking layer.Prepare glue
When capsule, in order to ensure that the mobility of sodium alginate soln, temperature are controlled at 60 DEG C.
Embodiment 5
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
The mixed solution of water, essence and calcium chloride, essence a concentration of 15%, calcium chloride solution concentration 10%；Prepare cyst wall layer, cyst wall
Layer raw material be sodium alginate soln, a concentration of 3%；The first water blocking layer is prepared, the first water blocking layer is cyanoacrylate；Prepare the
Two water blocking layers, the second water blocking layer are the mixed solution of light-cured resin monomer and initiator.Operating procedure is that (1) is dripped by counter
Method prepares capsule, and sandwich layer is the mixed solution of water, essence and calcium chloride, and cyst wall layer raw material is sodium alginate soln；(2) capsule table
Bread covers the first water blocking layer, and by capsules disperse obtained by step (1) in dimethyl carbonate, cyano third is added dropwise to above-mentioned dispersion
Olefin(e) acid ester type compound, until forming the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries capsule with diuresis promoting function table
Bread covers the second water blocking layer, i.e., photocuring tree is added dropwise in silicone oil, to above-mentioned dispersion in the capsules disperse obtained (2) step
The mixed solution of alicyclic monomer and initiator is stirred to react a period of time, until forming the second water blocking layer.When preparing capsule, in order to
Ensure that the mobility of sodium alginate soln, temperature are controlled at 60 DEG C.
Embodiment 6
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
The mixed solution of water, essence, calcium chloride and chitosan, essence a concentration of 10%, calcium chloride solution concentration 10%, chitosan is molten
Liquid concentration 1%；Cyst wall layer is prepared, the raw material of cyst wall layer is sodium alginate soln, sodium alginate soln a concentration of 3%；Prepare the
One water blocking layer, the first water blocking layer are cyanoacrylate；Prepare the second water blocking layer, the second water blocking layer be light-cured resin monomer with
The mixed solution of initiator.Operating procedure is that (1) prepares capsule by the anti-method of dripping, and sandwich layer is that water, essence, calcium chloride and shell are poly-
The mixed solution of sugar, cyst wall layer raw material are sodium alginate soln；(2) capsule surface coats the first water blocking layer, obtained by step (1)
Cyanoacrylate compound is added dropwise in dimethyl carbonate, to above-mentioned dispersion in capsules disperse, until forming the first resistance
Water layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries capsule with diuresis promoting function surface and coats the second water blocking layer, i.e., obtains (2) step
To capsules disperse in toluene, to above-mentioned dispersion be added dropwise light-cured resin monomer and initiator mixed solution, stirring
Reaction a period of time, until forming the second water blocking layer.When preparing capsule, in order to ensure the mobility of sodium alginate soln, temperature
Control is at 60 DEG C.
Embodiment 7
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
The mixed solution of water, essence, calcium chloride and chitosan, essence a concentration of 10%, calcium chloride solution concentration 10%, chitosan is molten
Liquid concentration 1%；Cyst wall layer is prepared, the raw material of cyst wall layer is sodium alginate soln, sodium alginate soln a concentration of 3%；Prepare the
One water blocking layer, the first water blocking layer are Instant cement 502；The second water blocking layer is prepared, the second water blocking layer is light-cured resin monomer
The mass ratio of the mixed solution of TTA21P and initiator UVI6976, TTA21P and UVI6976 are 100:4.Operating procedure is (1)
Capsule is prepared by the anti-method of dripping, sandwich layer is the mixed solution of water, essence, calcium chloride and chitosan, and cyst wall layer raw material is alginic acid
Sodium solution；(2) capsule surface coats the first water blocking layer, by step (1) gained capsules disperse in dimethyl carbonate, to above-mentioned point
Instant cement 502 is added dropwise in granular media system, until forming the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries glue
Capsule surface coats the second water blocking layer, i.e., the capsules disperse obtained (2) step is added dropwise in atoleine to above-mentioned dispersion
The mixed solution of TTA21P and UVI6976 is stirred to react a period of time, until forming the second water blocking layer.When preparing capsule, in order to
Ensure that the mobility of sodium alginate soln, temperature are controlled at 60 DEG C.
Embodiment 8
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Sandwich layer is prepared, sandwich layer is
The mixed solution of water, essence, calcium chloride and chitosan, essence a concentration of 10%, calcium chloride solution concentration 10%, chitosan is molten
Liquid concentration 1%；Cyst wall layer is prepared, the raw material of cyst wall layer is sodium alginate soln, sodium alginate soln a concentration of 3%；Prepare the
One water blocking layer, the first water blocking layer are the mixture of Instant cement 502 and Instant cement 508, and 502 and 508 mass ratio is 1:1；It prepares
Second water blocking layer, the second water blocking layer be light-cured resin monomer TTA21P and initiator UVI6976 mixed solution, TTA21P and
The mass ratio of UVI6976 is 100:0.4.Operating procedure is that (1) prepares capsule by the anti-method of dripping, and sandwich layer is water, essence, chlorination
The mixed solution of calcium and chitosan, cyst wall layer raw material are sodium alginate soln；(2) capsule surface coats the first water blocking layer, will walk
Suddenly the mixing of Instant cement 502 and Instant cement 508 is added dropwise to above-mentioned dispersion in dimethyl carbonate for capsules disperse obtained by (1)
Object, until forming the first water blocking layer；(3) the efficient anti-seepage leakage being prepared in step (2) carries the second resistance of capsule with diuresis promoting function surface cladding
TTA21P and UVI6976 is added dropwise in atoleine, to above-mentioned dispersion in water layer, i.e., the capsules disperse obtained (2) step
Mixed solution, be stirred to react a period of time, until formed the second water blocking layer.When preparing capsule, in order to ensure that sodium alginate is molten
The mobility of liquid, temperature are controlled at 60 DEG C.
Comparative example 1
A kind of preparation method of capsule, follows the steps below making：Sandwich layer is prepared, sandwich layer is water；Cyst wall layer is prepared,
Cyst wall layer raw material be sodium alginate soln, a concentration of 3%；Coagulating bath is calcium chloride solution, a concentration of 10%.Operating procedure is,
Capsule is prepared by the just method of dripping, sandwich layer is water, and cyst wall layer raw material is sodium alginate soln.When preparing capsule, in order to ensure seaweed
The mobility of sour sodium, control are 60 DEG C in temperature.
Comparative example 2
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Prepare sandwich layer, sandwich layer
For water；Preparing cyst wall layer, cyst wall layer raw material is sodium alginate soln, a concentration of 3%；Coagulating bath is calcium chloride solution, concentration
It is 10%；Water blocking layer is prepared, water blocking layer is beeswax, paraffin and Brazil wax, wherein beeswax 50%, paraffin 40%, cohune
Palmitic acid wax 10%.Operating procedure is that (1) prepares capsule by the just method of dripping, and sandwich layer is water, and cyst wall layer raw material is sodium alginate soln；
(2) capsule surface coats water blocking layer, and water blocking layer is beeswax 50%, paraffin 40%, Brazil wax 10%, and capsule is being mixed above
It closes in wax and handles 1min, then carry out low temperature solidification；When preparing capsule, in order to ensure that the mobility of sodium alginate, temperature control exist
60 DEG C, in order to ensure that the mobility of blended wax, temperature are controlled at 80 DEG C.
Comparative example 3
A kind of efficient anti-seepage leakage carries the preparation method of capsule with diuresis promoting function, follows the steps below making：Prepare sandwich layer, sandwich layer
For water and essence, essence a concentration of 20%；Prepare cyst wall layer, cyst wall layer raw material be sodium alginate soln, a concentration of 3%；Solidification
It is calcium chloride solution to bathe, a concentration of 10%；The first water blocking layer is prepared, the first water blocking layer is cyanoacrylate, the second water blocking layer
For light-cured resin.Operating procedure is that (1) prepares capsule by the just method of dripping, and sandwich layer is essence aqueous solution, and cyst wall layer raw material is sea
Solution of sodium alginate；(2) capsule surface coats the first water blocking layer, and capsule obtained by step (1) is added in cyanoacrylate, reaction
Until forming the first water blocking layer；(3) capsule surface being prepared in step (2) coats the second water blocking layer, i.e., obtains (2) step
To capsule be added in the mixed solution of light-cured resin monomer and initiator, reaction is until form the second water blocking layer.Prepare glue
In order to ensure the mobility of sodium alginate when capsule, temperature control is at 60 DEG C.
Capsule in above-described embodiment and comparative example is tested, the performance of capsule under different factors is compared.
Capsule diameter
10 capsules are taken at random, after blotting surface moisture with filter paper, every capsule is measured by digimatic calipers
Maximum particle diameter DmaxWith minimum grain size Dmin, record and calculate average grain diameter D；
Sphericity SF
By measuring the diameter of capsule, sphericity is calculated.
Its formula is：SF=(Dmax–Dmin)/(Dmax+Dmin)；SF value variation ranges are 0-1, and SF values are smaller, capsule shape
Closer to spherical.SF values are bigger, and capsule shape deviates spherical.Usually with SF<0.07 standard spherical in shape as capsule is judged.
Intensity
It is tested using DWY-iii dripping pill quality comprehensive testers；Since the capsule of the present invention can be used for cigarette field, because
This, it is desirable that capsule is easy to pinch brokenly, and intensity is between 10-16N.
Silica gel colour developing test
The principle of water discoloration, the anti-permeability of test capsule are met using silica gel, specific test method is：Randomly select 50
Capsule, is placed in sample bottle, and 50 discoloration silica gel are added, and the sample bottle equipped with sample and discoloration silica gel is placed in dry by sealing
In dry device, under the conditions of 25 DEG C, the color change of silica gel in sample bottle is observed at regular intervals.Coloring Time is measured to ooze to characterize
Water effect, testing time are 30 days, and observation whether there is discoloration in 30 days.
Permeability rate
20 capsules are randomly selected, are positioned in open environment, the weight-loss ratio of its 7 days and 30 days, as permeability rate are tested.
Table 1：Each results of property of capsule
Embodiment 13：The capsule that embodiment 6 is prepared, is added in cigaratte filter, and the perfume (or spice) containing quick-fried pearl is prepared
Cigarette filter tip.
Embodiment 14：The capsule that embodiment 1 is prepared, as drug capsule.
Embodiment 15：The capsule that embodiment 1 is prepared, as food additives, as food capsule.
Claims (9)
1. a kind of efficient anti-seepage leakage carries capsule with diuresis promoting function, it is characterised in that：Capsule is at least three-decker, is followed successively by core from inside to outside
Layer, cyst wall layer, the first water blocking layer, first water blocking layer are coated on outside cyst wall layer, are one or more cyanoacrylates
The polymerizate of compound, the efficient anti-seepage leakage carry 7 days permeability rates of capsule with diuresis promoting function and are less than 4%, sphericity SF<0.07.
2. a kind of efficient anti-seepage as described in claim 1 leakage carries capsule with diuresis promoting function, it is characterised in that capsule further includes the 4th layer, and the 4th
Layer is the second water blocking layer, and the second water blocking layer is coated on outside the first water blocking layer, and the second water blocking layer is light-cured resin.
3. a kind of as the leakage of claim 1-2 any one of them efficient anti-seepages carries capsule with diuresis promoting function, which is characterized in that sandwich layer is water or contains
Water component.
4. a kind of as the leakage of claim 1-2 any one of them efficient anti-seepages carries capsule with diuresis promoting function, which is characterized in that the cyst wall layer is
It is one or more in alginate, cellulose derivative, gelatin, chitosan, polyethylene glycol, polyvinyl alcohol.
5. a kind of efficient anti-seepage leakage according to any one of claims 1-4 carries the preparation method of capsule with diuresis promoting function, it is characterised in that packet
Include following steps：(1) capsule is prepared by dropping preparation method, sandwich layer is water or aqueous components, and cyst wall layer is alginate, cellulose spreads out
It is one or more in biology, gelatin, chitosan, polyethylene glycol, polyvinyl alcohol；(2) capsule surface coats the first water blocking layer；
(3) the efficient anti-seepage leakage being prepared in step (2) carries capsule with diuresis promoting function surface and coats the second water blocking layer.
6. a kind of efficient anti-seepage leakage as claimed in claim 5 carries the preparation method of capsule with diuresis promoting function, which is characterized in that the dropping preparation method
Method is dripped to be counter, temperature when preparing capsule is 50-80 DEG C.
7. a kind of efficient anti-seepage leakage as claimed in claim 5 carries the preparation method of capsule with diuresis promoting function, which is characterized in that the first resistance of cladding
The method of water layer is, by capsules disperse obtained by step (1), in a solvent, the solvent and water are immiscible, and not with cyanoacrylate
Acid esters compound reacts, solvent be dimethyl carbonate, butyl acetate, chloroform, silicone oil, petroleum ether, toluene, just oneself
Cyanoacrylate compound is added dropwise to dispersion in one or more of alkane, atoleine, blocks water until forming first
Layer.
8. a kind of efficient anti-seepage leakage as claimed in claim 5 carries the preparation method of capsule with diuresis promoting function, which is characterized in that the second resistance of cladding
The method of water layer is that in a solvent, which can not dissolve the first water blocking layer, with photocuring by capsules disperse obtained by step (2)
Resin is immiscible and will not react, and solvent is water, dimethyl carbonate, butyl acetate, chloroform, silicone oil, petroleum ether, first
One or more of benzene, n-hexane, atoleine are added dropwise light-cured resin monomer to above-mentioned dispersion while stirring and draw
Agent is sent out, then using ultraviolet lighting solidification the second water blocking layer of cladding.
9. a kind of application carrying capsule with diuresis promoting function such as the leakage of claim 1-8 any one of them efficient anti-seepages, it is characterised in that：By capsule
For food, medicine, Field of Tobacco.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810684856.3A CN108783554A (en) | 2018-06-28 | 2018-06-28 | A kind of leakage of efficient anti-seepage carries capsule with diuresis promoting function and preparation method thereof |
| CN201910552211.9A CN110250549B (en) | 2018-06-28 | 2019-06-24 | Efficient anti-seepage water-carrying capsule and preparation method thereof |
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| CN201810684856.3A CN108783554A (en) | 2018-06-28 | 2018-06-28 | A kind of leakage of efficient anti-seepage carries capsule with diuresis promoting function and preparation method thereof |
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| CN108783554A true CN108783554A (en) | 2018-11-13 |
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| CN201910552211.9A Active CN110250549B (en) | 2018-06-28 | 2019-06-24 | Efficient anti-seepage water-carrying capsule and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567261A (en) * | 2018-11-27 | 2019-04-05 | 江苏万腾新材料科技有限公司 | Using water-soluble material as three layers of cigarette capsule of core material and preparation method thereof |
| CN110419774A (en) * | 2019-07-10 | 2019-11-08 | 云南巴菰生物科技有限公司 | A kind of quick-fried pearl of water and preparation method thereof with double rubber layers |
| CN110961056A (en) * | 2019-11-18 | 2020-04-07 | 湖北中烟工业有限责任公司 | Water-carrying capsule capable of giving out brittle sound and containing hydrophilic silicon dioxide and preparation method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110841566B (en) * | 2019-11-18 | 2021-11-05 | 湖北中烟工业有限责任公司 | High-efficiency anti-seepage water-carrying capsule capable of giving out brittle sound |
| CN111205838A (en) * | 2020-02-26 | 2020-05-29 | 西南石油大学 | Composite microcapsule for fractured rock mass solidification seepage prevention and preparation method thereof |
| CN111758999A (en) * | 2020-06-22 | 2020-10-13 | 武汉纺织大学 | Chemical plating packaging blasting bead and preparation method and application thereof |
| CN114306273B (en) * | 2022-01-11 | 2023-03-17 | 新昌辽远科技有限公司 | Multilayer hollow capsule and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0938894A1 (en) * | 1998-02-16 | 1999-09-01 | Biomat B.V. | Implantable radiopaque device and use thereof |
| CN103071437B (en) * | 2012-10-09 | 2015-02-25 | 临沂宝力佳食品有限公司 | Secondary embedding method of docosahexaenoic acid |
| CN106914196A (en) * | 2017-04-11 | 2017-07-04 | 江南大学 | It is a kind of that the method for carrying water microcapsules is prepared based on liquid hoodle |
| CN107096476B (en) * | 2017-06-13 | 2020-04-14 | 武汉纺织大学 | Polyurethane mixed microcapsule and preparation method thereof |
| CN108041674B (en) * | 2017-11-29 | 2020-12-18 | 武汉纺织大学 | Efficient water-blocking anti-seepage capsule and preparation method thereof |
-
2018
- 2018-06-28 CN CN201810684856.3A patent/CN108783554A/en not_active Withdrawn
-
2019
- 2019-06-24 CN CN201910552211.9A patent/CN110250549B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109567261A (en) * | 2018-11-27 | 2019-04-05 | 江苏万腾新材料科技有限公司 | Using water-soluble material as three layers of cigarette capsule of core material and preparation method thereof |
| CN110419774A (en) * | 2019-07-10 | 2019-11-08 | 云南巴菰生物科技有限公司 | A kind of quick-fried pearl of water and preparation method thereof with double rubber layers |
| CN110961056A (en) * | 2019-11-18 | 2020-04-07 | 湖北中烟工业有限责任公司 | Water-carrying capsule capable of giving out brittle sound and containing hydrophilic silicon dioxide and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110250549B (en) | 2021-06-29 |
| CN110250549A (en) | 2019-09-20 |
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