CN108776251B - Induced potential measurement method and system - Google Patents

Induced potential measurement method and system Download PDF

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Publication number
CN108776251B
CN108776251B CN201810276653.0A CN201810276653A CN108776251B CN 108776251 B CN108776251 B CN 108776251B CN 201810276653 A CN201810276653 A CN 201810276653A CN 108776251 B CN108776251 B CN 108776251B
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CN
China
Prior art keywords
temperature
voltage
induced potential
medical instruments
alternating
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CN201810276653.0A
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Chinese (zh)
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CN108776251A (en
Inventor
万森
李路明
姜长青
白冰
莫晓龙
申伦豪
张锋
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清华大学
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R19/00Arrangements for measuring currents or voltages or for indicating presence or sign thereof
    • G01R19/0084Arrangements for measuring currents or voltages or for indicating presence or sign thereof measuring voltage only
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/37Monitoring; Protecting
    • A61N1/3718Monitoring of or protection against external electromagnetic fields or currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39Heart defibrillators
    • A61N1/3925Monitoring; Protecting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01KMEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K11/00Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
    • G01K11/32Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in transmission, scattering or fluorescence in optical fibres

Abstract

The application provides a kind of induced potential measurement method and system, by the temperature voltage relationship for obtaining the Medical Instruments, to calculate the induced potential for obtaining the output end of the Medical Instruments and generating in alternating magnetic field, induced potential bring error, accuracy with higher are measured by cable so as to avoid using voltage measuring apparatus.

Description

Induced potential measurement method and system

Technical field

This application involves the field of medical instrument technology more particularly to a kind of alternating electromagnetisms induced potential amount method and to be off field System.

Background technique

There are many implantation medical equipment type, such as pacemaker and defibrillator, embedded nerve stimulator, implanted flesh Meat stimulator etc..These medical instruments are by applying certain electric pulse to bodily tissue, to reach treatment, mitigate patient's disease The purpose of disease.

With advances in technology, Nuclear Magnetic Resonance increasingly becomes a kind of conventional detection means.For example, for receiving brain For the disturbances in patients with Parkinson disease of deep stimulation (deep brain stimulation, DBS) therapeutic scheme treatment, postoperative program-controlled ginseng Number usually requires the position of reference electrode.Therefore, carrying out postoperative scanning nuclear-magnetism to the disturbances in patients with Parkinson disease for receiving DBS treatment is very It is necessary.In addition, being equipped with the patient of implantation medical equipment even without in the inspection of the disease, other illnesss is being carried out When inspection, nuclear magnetic scanning can be also used.Due to having changing magnetic field during nuclear magnetic scanning, for using implantable medical instrument The patient of device, changing magnetic field can cause the raising of medical instrument metal spot temperature, and induce induced potential.The temperature rise On induced potential load patient tissue, certain damage may be caused to the tissue of patient.Therefore, for being equipped with implantation For the patient of formula Medical Instruments, nuclear magnetic scanning can generate a kind of potential danger.In order to eliminate the raised danger of temperature, the U.S. Material and test association (ASTM) provide body mould model criteria for simulating human body.Implantation medical equipment can be implanted into institute Body mould is stated, and nuclear magnetic scanning is carried out to the body mould.Then, nuclear-magnetism is scanned by body mould simulated medical instrument and measures temperature rise, thus It prejudges nuclear magnetic scanning and bring risk is increased by temperature.

In traditional technology, the metal position that the implantation medical equipment in body mould can be directly measured by oscillograph is inducted Voltage.Referring to Figure 1, in order to measure induced potential of the brain pacemaker system under nuclear-magnetism.Oscillograph can be placed on to nuclear-magnetism room Outside, contact in pacemaker shell or top cover is connected with one end of coaxial cable, with outside the other end connection nuclear-magnetism room of coaxial cable Oscillograph.Then, the induced potential that brain pacemaker system generates in nuclear magnetic scanning is detected by oscillograph.However, In actual measurement, since the alternating magnetic field that nuclear magnetic scanning generates also can be in coaxial cable and pacemaker coupling part and coaxial line Induced potential is generated on cable, this part induced potential, which is mixed into final measurement, can cause uncompensable errors.In addition, nuclear-magnetism is penetrated The induced potential of frequency field is about 64MHz (1.5T nuclear-magnetism) or 128MHz (3T nuclear-magnetism), and high frequency voltage requires in transmission process Impedance matching.In fact, the pulse that medical instrument issues is less than 1KHz mostly, it is defeated radio frequency is not related in normal use process Out, impedance matching will not be done.In summary consider, traditional technology directly measures implantation medical equipment and produces in superpower alternating magnetic field It is that the method for raw induced potential obtains the result is that inaccuracy, and error is difficult to estimation control.

Summary of the invention

Based on this, it is necessary in view of the above technical problems, truly have and provide a kind of measurement side of more accurate and reliable induced potential Method and system, the potential risk in order to accurate evaluation nuclear magnetic scanning to the patient for using implantation medical equipment.

A kind of induced potential measuring system, the induced potential generated in alternating magnetic field for measuring Medical Instruments are described Medical Instruments includes conductor part, and the output end connecting with the conductor part, comprising:

Temperature measuring device, when being in alternating magnetic field to measure the Medical Instruments, the first temperature of the output end When degree increment and the Medical Instruments are not in alternating magnetic field, the second temperature increment of the output end;

Voltage provides device, to apply to the Medical Instruments when the Medical Instruments is not in alternating magnetic field Alternating voltage is so that output end heating reaches the second temperature increment, when the pulse envelope of the alternating voltage, unit Interior pulse number and pulsewidth and the pulse envelope of the alternating magnetic field, the pulse number in the unit time and pulsewidth phase Together;

The induced potential computing device that device is connect is provided with the temperature-sensing device and the voltage, to according to more The voltage magnitude of a second temperature increment alternating voltage corresponding with the multiple second temperature increment obtains voltage magnitude With the temperature voltage corresponding relationship of temperature increment, and first temperature increment calculated according to the temperature voltage corresponding relationship Corresponding voltage magnitude.

A kind of measurement method of induced potential, the induced potential generated in alternating magnetic field for measuring Medical Instruments, institute The output end that Medical Instruments includes conductor part and connect with the conductor part is stated, the measurement method includes following step It is rapid:

Apply alternating magnetic field to the Medical Instruments, obtains the first temperature increment of the output end, first temperature Increment is described in the temperature and the Medical Instruments when output end reaches stable state in the alternating magnetic field are not in The difference of temperature when in alternating magnetic field;

The alternating magnetic field for being applied to the Medical Instruments is closed, applies alternating voltage so that described defeated to the Medical Instruments Outlet heating, the pulse envelope of the alternating voltage, the pulse number in the unit time and pulsewidth are identical as the alternating magnetic field;

Obtain multiple second temperature increments of the corresponding output end of different voltages amplitude of the alternating voltage;

The second temperature increment and institute are obtained according to the multiple second temperature increment and the different voltages amplitude The temperature voltage corresponding relationship of voltage magnitude is stated, and first temperature increment pair is calculated according to the temperature voltage corresponding relationship The voltage magnitude answered.

The measurement method of induced potential measuring system provided by the present application and induced potential, by obtaining the medical instrument The temperature voltage relationship of device, to calculate the induced potential for obtaining the output end of the Medical Instruments and generating in alternating magnetic field, from And it avoids and induced potential bring error, accuracy with higher is measured by cable using voltage measuring apparatus.

Detailed description of the invention

Fig. 1 is the method schematic diagram for the induced potential that measurement Medical Instruments generates in nuclear magnetic resonance in traditional technology;

Fig. 2 is the application environment schematic diagram of the induced potential measuring system in the application one embodiment;

Fig. 3 is the structural schematic diagram of induced potential measuring system in the application one embodiment;

Fig. 4 is that the temperature measuring device of induced potential measuring system in the application one embodiment measures output end temperature Schematic diagram;

Fig. 5 provides device for the voltage of induced potential measuring system in the application one embodiment and applies electricity to Medical Instruments The schematic diagram of pressure;

Fig. 6 is the RF pulse envelope of the alternating magnetic field obtained according to the MRI scan sequence of nuclear magnetic resonane scanne Figure;

Fig. 7 is that the voltage measuring apparatus of induced potential measuring system in the application one embodiment measures the Medical Instruments Original induced potential schematic diagram;

Fig. 8 is the flow chart of induced potential measurement method in the embodiment of the present application;

Fig. 9 is second temperature increment and induced potential magnitude relation curve graph in the embodiment of the present application.

Component symbol explanation

Induced potential measuring system 10

Body mould 110

Medical Instruments 120

Impulse generator 122

Conductor part 124

Output end 126

Temperature measuring device 130

Optical fiber temperature-measurement device 132

Temperature indicator 134

Optical fiber 136

Voltage measuring apparatus 140

Oscillograph 142

Coaxial cable 144

Voltage provides device 150

Signal generator 152

Power amplifier 154

Induced potential computing device 160

Specific embodiment

In order to which the objects, technical solutions and advantages of the application are more clearly understood, below in conjunction with attached drawing to the application's Induced potential measurement method and system are described.It should be appreciated that specific embodiment described herein is only used to explain this Application is not used to limit the application.

Fig. 2-4 is referred to, the embodiment of the present application provides a kind of induced potential measuring system 10, for measuring Medical Instruments 120 induced potentials generated in alternating magnetic field.The Medical Instruments 120 include conductor part 124, and with the conductor portion The output end 126 of part connection.The induced potential measuring system 10 includes:

Temperature measuring device 130, when being in alternating magnetic field for measuring the Medical Instruments 120, the output end 126 The first temperature increment and the Medical Instruments 120 when being not in alternating magnetic field, the second temperature of the output end 126 Increment;

Voltage provides device 150, for giving the medical instrument when the Medical Instruments 120 is not in alternating magnetic field Device 120 applies alternating voltage so that the heating of the output end 126 reaches the second temperature increment, the pulse of the alternating voltage Envelope, pulse number and pulse envelope, the pulse number in the unit time of pulsewidth and the alternating magnetic field in the unit time And pulsewidth is identical;

The induced potential computing device 160 that device 150 is connect is provided with the temperature-sensing device 130 and the voltage, For being obtained according to the voltage magnitude of multiple second temperature increments alternating voltage corresponding with the multiple second temperature increment It takes the temperature voltage corresponding relationship of voltage magnitude and temperature increment, and calculates described the according to the temperature voltage corresponding relationship The corresponding voltage magnitude of one temperature increment.

The Medical Instruments 120 can be the implantation medical equipment of various implantation human bodies, including and be not limited to heart It fights device and defibrillator, embedded nerve stimulator and implanted muscle stimulator.The alternating magnetic field can be to be total to by nuclear-magnetism The scanner that shakes carries out the superpower alternating magnetic field of generation when nuclear magnetic scanning.The Medical Instruments 120 includes impulse generator 122, leads Body component 124 and output end 126.The conductor part 124 is connect with the impulse generator 122 and the output end 126. The pulse signal that the impulse generator 122 issues passes to the output end 126 by the conductor part 124 and passes through described Output end 126 is applied to human body.The Medical Instruments 120 can be implanted in body mould 110.There is class in the body mould 110 Like the environment of tissue, so as to simulate the et al. Ke environment of human body.

The body mould 110 can be placed in the scanning room of nuclear magnetic resonane scanne, when opening scanning, the body mould 110 in alternating magnetic field.It is described in the body mould 110, the Medical Instruments 120 is in the output end 126 and the arteries and veins It rushes between generator 122 and forms loop.When the Medical Instruments 120 is in the alternating magnetic field, the loop, which can generate, inducts Electric current increases so as to cause the temperature of the output end 126.The output end 126 can be multiple metal electrodes.In a reality It applies in example, when the Medical Instruments 120 is brain pacemaker, the output end 126 is two electrodes for having hard contact.Institute When stating the setting of output end 126 in the body mould 110, due to being filled with gel tissue in the body mould 110, so that the output There is impedance between end 126 and the shell of the impulse generator 122.This impedance can be defined as the output end 126 Impedance.

The temperature measuring device 130 is used to measure the temperature of the output end 126.The temperature measuring device 130 is not Limit, can be the various temperature measuring equipments not influenced by alternating magnetic field.Fig. 4 is referred to, in one embodiment, the temperature measurement Device 130 includes optical fiber temperature-measurement device 132 and the temperature indicator 134 connecting with the optical fiber temperature-measurement device 132.The optical fiber Thermal detector 132 measures the temperature of the output end 126 by optical fiber 136.The temperature indicator 134 is for showing the optical fiber The measurement result of thermal detector 132.The temperature that the output end 126 is measured by the optical fiber temperature-measurement device 132, due to optical fiber 136 not will receive the influence of the alternating magnetic field, to accurately obtain temperature-measuring results.Specifically, the body mould 110 is being put into After the scanning chamber for stating nuclear magnetic resonane scanne, the nuclear magnetic resonane scanne will be scanned the body mould 110, to give The body mould 110 applies alternating magnetic field.

In the alternating magnetic field, the metal part in the Medical Instruments 120 can generate induced potential, and with it is described Liquid forming circuit in body mould 110.Under induced potential effect, the output end 126 has hair caused by electromagnetic field Heat, so that the output end 126 can be caused to heat up.The optical fiber temperature-measurement device 132 can be sensed described by the optical fiber 132 The temperature of output end 126.Temperature of the output end 126 in no application alternating current magnetic field is room temperature temperature.It is described defeated Outlet 126 can be warming up to stable state under alternating current magnetic field effect.The temperature of the output end 126 when the stable state Degree and the difference of the room temperature temperature are defined as first temperature increment.The optical fiber temperature-measurement device 132 can measure described One temperature increment, and shown in the temperature indicator 134.It is appreciated that the alternating current magnetic field can pass through core Magnetic resonance scanner provides.For example, when the scanning that the body mould 110 enters the nuclear magnetic resonane scanne is intracavitary, if opening The scanning function of the nuclear magnetic resonane scanne, the body mould 110 will be in alternating magnetic field.When the closing nuclear magnetic resonance When the scanning function of scanner, the body mould 110 is at the state for not applying alternating magnetic field, thus the Medical Instruments 120 Just it is not in alternating magnetic field.

Fig. 5 is referred to, the voltage provides device 150 and is used to provide alternating voltage to the Medical Instruments 120, so that institute The output end 126 for stating Medical Instruments 120 heats up.The voltage provides the pulse envelope for the alternating voltage that device 150 provides, unit Pulse envelope, the pulse number and pulsewidth in the unit time of pulse number and pulsewidth and the alternating magnetic field in time It is identical.The voltage provide the alternating voltage that device 150 provides frequency can it is identical with the frequency of the alternating magnetic field or It is different.The alternating voltage of different amplitudes is provided to the Medical Instruments 120, can make the Medical Instruments 120 that there is difference Second temperature increment.Specifically, the amplitude for the alternating voltage that device 150 exports can be provided by adjusting the voltage to adjust The whole Medical Instruments 120 increases multiple and different temperature, to obtain multiple and different second temperature increments.

Refer to Fig. 5, in one embodiment, the voltage provide device 150 include signal generator 152, with it is described The power amplifier 154 that signal generator 152 connects.The power amplifier 154 is applied by conducting wire to the Medical Instruments 120 Add the alternating voltage.The pulse envelope for the alternating voltage signal that in one embodiment, the signal generator 152 generates, Pulse envelope, the pulse number and pulsewidth in the unit time of pulse number and pulsewidth and the alternating magnetic field in unit time It is identical.The alternating voltage signal that the power amplifier 154 is used to generate the signal generator 152 amplifies.Specifically, may be used Alternating voltage to be applied between the output end 126 and pulse signal generator 122 of the Medical Instruments 120 by conducting wire. That is, an electrode connects the output end 126, another electrode connects the shell of the pulse signal generator 122 On body.Above-mentioned two electrode is connect by conducting wire with the output of the power amplifier 154.Logical to the Medical Instruments 120 When electric, the temperature of the output end 126 can be by 130 real-time measurement of temperature measuring device, it is hereby achieved that being applied to The corresponding second temperature increment of the amplitude of alternating current in the Medical Instruments 120.

The induced potential computing device 160 is the intelligent terminal with computing function.The induced potential computing device 160, which provide device 150 with the temperature measuring device 130 and the voltage, is electrically connected.The induced potential computing device 160 can To provide the voltage magnitude that device 150 is applied to the alternating current in the Medical Instruments 120 according to the voltage, and by described The second temperature increment of the corresponding output end 126 of the voltage magnitude for the alternating current that temperature measuring device 130 measures, Obtain the temperature voltage corresponding relationship curve of the second temperature increment Yu the voltage magnitude.The induced potential computing device 160 can also calculate the corresponding voltage magnitude of first temperature increment according to the temperature voltage corresponding relationship curve.It is described First temperature increment is the induced potential bring temperature increment generated by the alternating current magnetic field, and first temperature increment is corresponding Voltage magnitude be exactly the induced potential voltage magnitude.Also, the frequency due to the induced potential, pulse envelope, list In the time of position pulse number and pulsewidth with the frequency of the alternating current magnetic field, pulse envelope, pulse number phase in the unit time Together.After the voltage magnitude for obtaining the induced potential, in the frequency of the alternating current magnetic field, pulse envelope, in the unit time Pulse number and pulsewidth on the basis of be obtained with the complete information of the induced potential.

When the frequency of the alternating voltage and the frequency difference of the alternating magnetic field, the induced potential calculates dress It sets 160 and the impedance of the output end 126 and voltage offer device application under the frequency according to the induced potential is provided Alternating voltage frequency under the output end 126 impedance ratio calculation curve amendment coefficient, and according to the curve Correction factor corrects the temperature voltage corresponding relationship.That is, when the alternating voltage applied to the Medical Instruments 120 and The frequency phase of the alternating magnetic field corresponds to meanwhile, it is capable to directly calculate the first temperature increment according to temperature voltage corresponding relationship curve Voltage magnitude.

When the frequency difference of the alternating voltage and the alternating magnetic field that apply to the Medical Instruments 120, basis is needed The impedance of the output end 126 is corrected the temperature voltage curve under different frequency.Specifically, the Medical Instruments 120 in the alternating magnetic field when, the impedance of the output end 126 is R1.Apply alternating voltage to the Medical Instruments 120 Frequency under, the impedance of the output end 126 is R2.The curve amendment coefficient isTherefore, the temperature voltage pair Should be related to should be multiplied byTo correct temperature voltage corresponding relationship corresponding relationship caused by impedance variations under different frequency Variation.The alternating current magnetic field frequency, pulse envelope, the pulse number in the unit time and pulsewidth can pass through MRI scan The MRI scan sequence of instrument directly obtains, and can also be obtained by the way of measuring original induced potential.Fig. 6 is referred to, For the envelope of 90 ° of radio-frequency pulses of Philip Achieva 3T magnetic resonance bold sequence, actual radiofrequency field is 128MHz variation Alternating magnetic field.The alternating magnetic field inducts to obtain induced potential also form having the same in the Medical Instruments 120, only Amplitude unlike one.

In one embodiment, the induced potential measuring system 10 can further include voltage measuring apparatus 140, For obtaining frequency, the pulse envelope, the arteries and veins in the unit time of the alternating magnetic field by the way of measuring original induced potential Rush number and pulsewidth.Due to the frequency of the original induced potential, pulse envelope, pulse number and the alternation in the unit time The frequency in magnetic field, pulse envelope, the pulse number between unit are identical, can be by using the mode for measuring original induced potential Obtain the pulse envelope of the alternating magnetic field, pulse number and pulsewidth in the unit time.

Please also refer to Fig. 7, the voltage measuring apparatus 140 may include oscillograph 142 and with the oscillograph 142 The coaxial cable 144 of connection.The oscillograph 142 is placed on outside the scanning room of the nuclear magnetic resonane scanne, by described same Shaft cable 144 is connect with the shell of the output end 126 of the Medical Instruments 120 and pulse signal generator 122.When the nuclear-magnetism When the scanning function of resonance scanner is opened, the Medical Instruments 120 is in alternating magnetic field, can pass through the oscillography at this time Device 142 directly acquires the original induced potential that the Medical Instruments 120 generates in alternating magnetic field.Due to the coaxial cable 144 are partially in scanning room, therefore in scanning, the coaxial cable 144 can also generate induced potential.

The original induced potential is exactly the induced potential that the Medical Instruments 120 is generated with the coaxial cable 144 With.Frequency, pulse envelope, the pulse number in the unit time and the pulsewidth of the original induced potential at this time and the alternation The frequency in magnetic field, pulse envelope, the pulse number in the unit time and pulsewidth are identical.Therefore, the induced potential can be passed through Measuring system 10 gets frequency, pulse envelope, pulse number and the pulsewidth in the unit time of the alternating magnetic field.In this base It, can be by the voltage application device 150 to the pulse packet of the Medical Instruments 120 input and the alternating magnetic field on plinth Network, pulse number and the identical alternating voltage of pulsewidth obtain the voltage temperature curve in the unit time.It is appreciated that institute Stating voltage measuring apparatus 140 is a kind of optional technical solution.When the MRI scan of nuclear magnetic resonane scanne can be passed through Sequence directly obtains the pulse envelope of alternating magnetic field, in the unit time pulse number and when pulsewidth without voltage survey Measure device 140.

Induced potential measuring system 10 provided by the present application can be used for measuring Medical Instruments 120 and produce in alternating magnetic field Raw induced potential.The induced potential measuring system 10 provides device 150 by voltage and applies alternation electricity to Medical Instruments 120 Pressure.The temperature measuring device 130 can measure the corresponding second temperature increment of the different amplitude of the alternating voltage.To, The induced potential computing device 160 obtains the corresponding relationship of the second temperature increment and voltage magnitude.The temperature Measuring device 130 can also measure first temperature increment of the Medical Instruments 120 in alternating magnetic field.The induced potential meter Calculate the amplitude that device 160 obtains the induced potential by first temperature increment and the temperature voltage corresponding relationship.By In the frequency of the induced potential, pulse envelope, pulse number and pulsewidth and the frequency of the alternating magnetic field in the unit time, Pulse number and pulsewidth between pulse envelope, unit is identical, it is hereby achieved that all information of the induced potential.Cause This, induced potential of the Medical Instruments 120 that induced potential measuring system 10 provided by the present application measures in alternating magnetic field is whole It is the induced potential for being generated by Medical Instruments 120 itself, and not including the generation of measurement cable, accuracy is higher.

Please also refer to Fig. 8, the embodiment of the present application further provides for a kind of measurement method of induced potential, for measuring doctor The induced potential that instrument 120 generates in alternating magnetic field is treated, the Medical Instruments 120 includes impulse generator 122 and the arteries and veins The output end 126 for rushing the conductor part 124 of the connection of generator 122 and being connect with the conductor part 124, the measurement side Method the following steps are included:

S110 applies alternating magnetic field to the Medical Instruments 120, obtains the first temperature increment of the output end 126, institute Stating the first temperature increment is temperature and the medical instrument when output end 126 reaches stable state in the alternating magnetic field The difference of room temperature temperature when device 120 is not in the alternating magnetic field.

The Medical Instruments 120 can be set in body mould 110, and the Medical Instruments 120 is closed with the body mould 110 composition Close circuit.Specifically, the alternating magnetic field can be provided by nuclear magnetic resonane scanne.The body mould 110 is placed on the core In the scanning room of magnetic resonance scanner, when the nuclear magnetic resonane scanne opens scanning function, the Medical Instruments 120 will be located In the magnetic field of alternation.For the body mould 110 in the scanning room, the alternating current magnetic field applies the medical treatment after a certain period of time The temperature of the output end 126 of instrument 120 can reach a stationary value.The stationary value of the temperature and the output end 126 be not The difference of room temperature temperature when generation induced potential is exactly first temperature increment.The temperature measuring device can be passed through 130 measure first temperature increment.Specifically, the output end 126 can be measured by the method for optical fiber temperature-measurement Temperature.Since optical fiber not will receive the influence of alternating magnetic field, so that the temperature of the output end 126 of measurement is more accurate.

S120 closes the alternating magnetic field for being applied to the Medical Instruments 120, applies alternation electricity to the Medical Instruments 120 It presses so that the heating of the output end 126, the pulse envelope of the alternating voltage, the pulse number in the unit time and pulsewidth and institute It is identical to state alternating magnetic field.

Due to the pulse envelope of the induced potential, the pulse number in the unit time and pulsewidth and the alternating magnetic field phase Together.The pulse with alternating magnetic field pulse envelope having the same, in the unit time to the Medical Instruments 120 application can be passed through Several and pulsewidth alternating voltage is so that the output end 126 heats up, to simulate the induced potential in the output end The heating of 126 brings.Frequency, pulse envelope, the pulse number in the unit time and the pulsewidth of the alternating magnetic field can lead to The MRI scan sequence for crossing nuclear magnetic resonane scanne directly obtains, and can also be obtained by the way of measuring original induced potential ?.Specifically, the alternating voltage can provide device 150 by the voltage and be applied in the Medical Instruments 120.

S130 obtains multiple second temperatures of the corresponding output end 126 of different voltages amplitude of the alternating voltage Increment.

The different voltage magnitude of the alternating voltage can make the output end 126 have different heatings.It therefore, can be with By inputting the alternating voltage of different voltages amplitude to the Medical Instruments 120, so that the output end 126 has different liters Temperature value, that is, multiple second temperature increments.Then it can recorde the corresponding second temperature increment of each voltage magnitude.The step It can be executed by the induced potential computing device 160.

S140 obtains the second temperature increment according to the multiple second temperature increment and the different voltages amplitude With the temperature voltage corresponding relationship of the voltage magnitude, and first temperature is calculated according to the temperature voltage corresponding relationship and is increased Measure corresponding voltage magnitude.

After obtaining the multiple second temperature increment and each corresponding voltage magnitude of second temperature increment, The temperature voltage corresponding relationship between the second temperature increment and voltage magnitude can be simulated.Fig. 9 is referred to, Fig. 9 is Second temperature increment and induced potential magnitude relation curve graph.The temperature voltage of the second temperature increment and the voltage magnitude In corresponding relationship, the second temperature increment and the voltage magnitude are quadratic function relation.In the corresponding pass of the temperature voltage On the basis of system, the corresponding voltage magnitude of the induced potential can be obtained by first temperature increment.Due to the sense Frequency, envelope and the pulsewidth of raw voltage are identical as the frequency of the nuclear magnetic resonane scanne, envelope and pulsewidth.Therefore, exist After the voltage magnitude for obtaining the induced potential, so that it may according to the frequency pulse envelope of the nuclear magnetic resonane scanne, Pulse number and pulsewidth obtain all information of the induced potential in unit time.Specifically, which can be by described Induced potential computing device 160 executes.

In one embodiment, the step S140 can with the following steps are included:

S142 obtains the second temperature increment according to the multiple second temperature increment and the different voltages amplitude With the temperature voltage corresponding relationship of the voltage magnitude;

S144, when the frequency of the alternating voltage and the frequency difference of the alternating magnetic field, according to the induced potential Frequency under the output end 126 impedance and the voltage provide device apply alternating voltage frequency under the output end The ratio calculation curve amendment coefficient of 126 impedance, and the temperature voltage is corrected according to the curve amendment coefficient and is corresponded to Relationship;

S146 calculates the corresponding voltage magnitude of first temperature increment according to the temperature voltage corresponding relationship.

In the S144, when the frequency of the alternating voltage and the frequency difference of the alternating magnetic field, the sense Raw voltage computing device 160 is also used to the impedance of the output end 126 and the voltage under the frequency according to the induced potential The ratio calculation curve amendment coefficient of the impedance of the output end 126 under the frequency for the alternating voltage that device applies is provided.Also It is to say, when the frequency phase of the alternating voltage and the alternating magnetic field of giving the Medical Instruments 120 to apply is meanwhile, it is capable to direct basis Temperature voltage corresponding relationship curve calculates the corresponding voltage magnitude of the first temperature increment.When what is applied to the Medical Instruments 120 When the frequency difference of alternating voltage and the alternating magnetic field, the impedance ground according to output end 126 described under different frequency is needed The temperature voltage curve is corrected.Specifically, when the Medical Instruments 120 is in the alternating magnetic field, the output The impedance at end 126 is R1.Under the frequency for applying alternating voltage to the Medical Instruments 120, the impedance of the output end 126 is R2.The curve amendment coefficient isTherefore, in the S146, the temperature voltage corresponding relationship should be multiplied byTo correct the variation of temperature voltage corresponding relationship corresponding relationship caused by impedance variations under different frequency.It is appreciated that When the frequency of the alternating magnetic field, the pulse number in the pulse envelope unit time and pulsewidth can not directly acquire, the sense The measurement method of raw voltage can further include the frequency for obtaining the alternating magnetic field, the arteries and veins in the pulse envelope unit time The step of rushing number and pulsewidth, comprising:

S210 obtains the Medical Instruments 120 and the coaxial cable 144 connecting with the Medical Instruments 120 described The original induced potential generated in alternating magnetic field;

S220 obtains the frequency of the alternating magnetic field, in the pulse envelope unit time by the original induced potential Pulse number and pulsewidth, frequency, the pulse number in the pulse envelope unit time and the pulsewidth of the original induced potential and institute Frequency, the pulse number in the pulse envelope unit time and the pulsewidth for stating alternating magnetic field are equal.

The original induced potential includes the induced potential and the coaxial cable 144 that the Medical Instruments 120 generates The induced potential of generation.The original induced potential can be measured by the voltage measuring apparatus 140.Due to the original sense Frequency, the pulse number in the pulse envelope unit time and the pulsewidth of raw voltage and frequency, the pulse envelope of the alternating magnetic field Pulse number and pulsewidth in unit time is equal, can obtain the alternating magnetic field by measuring the original induced potential Frequency, the pulse number in the pulse envelope unit time and pulsewidth.

The measurement method of induced potential provided by the embodiments of the present application, for obtaining Medical Instruments 120 in alternating magnetic field The induced potential of generation.By obtaining the temperature voltage relationship of the Medical Instruments 120, the Medical Instruments is obtained to calculate The induced potential that 120 output end 126 generates in alternating magnetic field is surveyed so as to avoid using voltage measuring apparatus by cable Measure induced potential bring error, accuracy with higher.

Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.

Claims (10)

1. a kind of induced potential measuring system, the induced potential generated in alternating magnetic field for measuring Medical Instruments, the doctor Treating instrument includes conductor part, and the output end connecting with the conductor part characterized by comprising
Temperature measuring device, when being in alternating magnetic field to measure the Medical Instruments, the first temperature of the output end increases When amount and the Medical Instruments are not in alternating magnetic field, the second temperature increment of the output end;
Voltage provides device, to apply alternation to the Medical Instruments when the Medical Instruments is not in alternating magnetic field Voltage is so that output end heating reaches the second temperature increment, the pulse envelope of the alternating voltage, in the unit time Pulse number and pulsewidth are identical as the pulse envelope of the alternating magnetic field, the pulse number in the unit time and pulsewidth;
The induced potential computing device that device is connect is provided with the temperature measuring device and the voltage, to according to multiple institutes The voltage magnitude for stating second temperature increment alternating voltage corresponding with the multiple second temperature increment obtains voltage magnitude and temperature The temperature voltage corresponding relationship of increment is spent, and first temperature increment is calculated according to the temperature voltage corresponding relationship and is corresponded to Voltage magnitude.
2. induced potential measuring system as described in claim 1, which is characterized in that the temperature measuring device includes that optical fiber is surveyed Warm device and the temperature indicator connecting with the optical fiber temperature-measurement device, the optical fiber temperature-measurement device described in optical fiber measurement by exporting The temperature at end, the temperature indicator are used to show the measurement result of the optical fiber temperature-measurement device.
3. induced potential measuring system as described in claim 1, which is characterized in that it includes signal hair that the voltage, which provides device, Raw device, the power amplifier connecting with the signal generator, the power amplifier are applied by conducting wire to the Medical Instruments Add the alternating voltage.
4. induced potential measuring system as described in claim 1, which is characterized in that it further comprise voltage measuring apparatus, it is described Voltage measuring apparatus is for measuring the Medical Instruments and the coaxial cable being connected with the Medical Instruments in the alternation magnetic The original induced potential that generates in, the frequency of the original induced potential, pulse envelope, in the unit time pulse number and Pulse number and pulsewidth between pulsewidth and the frequency of the alternating magnetic field, pulse envelope, unit is identical.
5. induced potential measuring system as described in claim 1, which is characterized in that the frequency of the alternating voltage and the friendship When the frequency difference of varying magnetic field, the induced potential computing device is also used to the output under the frequency according to the induced potential The ratio calculation of the impedance of the output end is bent under the frequency for the alternating voltage that the impedance at end and voltage offer device apply Line correction factor, and the temperature voltage corresponding relationship is corrected according to the curve amendment coefficient.
6. a kind of measurement method of induced potential, the induced potential generated in alternating magnetic field for measuring Medical Instruments is described Medical Instruments includes conductor part and the output end that connect with the conductor part, the measurement method the following steps are included:
Apply alternating magnetic field to the Medical Instruments, obtains the first temperature increment of the output end, first temperature increment Temperature and the Medical Instruments when reaching stable state in the alternating magnetic field for the output end are not in the alternation The difference of temperature when in magnetic field;
The alternating magnetic field for being applied to the Medical Instruments is closed, applies alternating voltage so that the output end to the Medical Instruments Heating, the pulse envelope of the alternating voltage, the pulse number in the unit time and pulsewidth are identical as the alternating magnetic field;
Obtain multiple second temperature increments of the corresponding output end of different voltages amplitude of the alternating voltage;
The second temperature increment and the electricity are obtained according to the multiple second temperature increment and the different voltages amplitude The temperature voltage corresponding relationship of pressure amplitude value, and it is corresponding according to temperature voltage corresponding relationship calculating first temperature increment Voltage magnitude.
7. method as claimed in claim 6, which is characterized in that further comprise the frequency for obtaining the alternating magnetic field, pulse Envelope, pulse number and the step of pulsewidth in the unit time, comprising:
Obtain the Medical Instruments and original that the coaxial cable connecting with the Medical Instruments generates in the alternating magnetic field Beginning induced potential;
Frequency, envelope and the pulsewidth of the alternating magnetic field are obtained by the original induced potential, the original induced potential Frequency, pulse envelope, frequency, pulse envelope, the unit of pulse number and pulsewidth and the alternating magnetic field in the unit time Pulse number and pulsewidth are equal in time.
8. method as claimed in claim 6, which is characterized in that the Medical Instruments is set in body mould, the Medical Instruments Closed circuit is constituted with the body mould.
9. method according to claim 8, which is characterized in that the temperature of the second temperature increment and voltage magnitude electricity It presses in corresponding relationship, the second temperature increment and the voltage magnitude are quadratic function relation.
10. method as claimed in claim 9, which is characterized in that described according to the multiple second temperature increment and described Different voltages amplitude obtains the temperature voltage corresponding relationship of the second temperature increment Yu the voltage magnitude, and according to the temperature Degree voltage corresponding relationship calculates the corresponding voltage magnitude of first temperature increment
The second temperature increment and the electricity are obtained according to the multiple second temperature increment and the different voltages amplitude The temperature voltage corresponding relationship of pressure amplitude value;
When the frequency of the alternating voltage and the frequency difference of the alternating magnetic field, according to institute under the frequency of the induced potential The ratio of the impedance of the output end under the frequency for the alternating voltage that the impedance and voltage offer device for stating output end apply Calculated curve correction factor, and the temperature voltage corresponding relationship is corrected according to the curve amendment coefficient;
The corresponding voltage magnitude of first temperature increment is calculated according to the temperature voltage corresponding relationship.
CN201810276653.0A 2018-03-30 2018-03-30 Induced potential measurement method and system CN108776251B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0458466A2 (en) * 1990-05-21 1991-11-27 Sumitomo Electric Industries, Limited Hall device
CN103412009A (en) * 2013-08-21 2013-11-27 中国海洋石油总公司 Fluid conductivity sensor, and device and method for measuring fluid conductivity
CN107301947A (en) * 2016-03-31 2017-10-27 比亚迪股份有限公司 Power semiconductor with temperature detection and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4406585B2 (en) * 2004-07-27 2010-01-27 三井造船株式会社 Induction voltage detection method and apparatus, and induction heating system
CN101750161A (en) * 2008-12-08 2010-06-23 黑龙江乾丰科技发展有限公司 Method for measuring temperature of conductor in strong alternating electromagnetic field
JP4760926B2 (en) * 2009-02-05 2011-08-31 株式会社デンソー Indicators for vehicles
CN102374896B (en) * 2011-09-19 2013-01-16 基康仪器(北京)有限公司 Method and device for measuring equal precision frequency of single coil vibrating wire instrument
JP5813727B2 (en) * 2013-11-01 2015-11-17 コスモヘルス株式会社 Potential therapy device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0458466A2 (en) * 1990-05-21 1991-11-27 Sumitomo Electric Industries, Limited Hall device
CN103412009A (en) * 2013-08-21 2013-11-27 中国海洋石油总公司 Fluid conductivity sensor, and device and method for measuring fluid conductivity
CN107301947A (en) * 2016-03-31 2017-10-27 比亚迪股份有限公司 Power semiconductor with temperature detection and preparation method thereof

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