CN108761053A - A kind of saliva crystallization chip - Google Patents
A kind of saliva crystallization chip Download PDFInfo
- Publication number
- CN108761053A CN108761053A CN201810917074.XA CN201810917074A CN108761053A CN 108761053 A CN108761053 A CN 108761053A CN 201810917074 A CN201810917074 A CN 201810917074A CN 108761053 A CN108761053 A CN 108761053A
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- China
- Prior art keywords
- chip
- saliva
- crystallization
- filtrating
- filter
- Prior art date
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- 210000003296 saliva Anatomy 0.000 title claims abstract description 110
- 238000002425 crystallisation Methods 0.000 title claims abstract description 69
- 230000008025 crystallization Effects 0.000 title claims abstract description 67
- 238000001914 filtration Methods 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 9
- 239000011521 glass Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 230000016087 ovulation Effects 0.000 description 14
- 239000013078 crystal Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 3
- 210000003756 cervix mucus Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241001494479 Pecora Species 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001315 dental pellicle Anatomy 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A kind of saliva crystallization chip, including filtrating chip and the crystallization chip below filtrating chip;The open type saliva collection chamber for saliva quantitative collection and storage is provided on filtrating chip;Saliva collection bottom of chamber portion is communicated with the filter that can eliminate bubble and swill in saliva;Filtrating chip is provided at both ends with limited post;It is provided with limiting platform corresponding with limited post position on crystallization chip, and it is provided on limiting platform and the matched limit hole of limited post, limited post coordinates with limit hole, limits the relative position of filtrating chip and crystallization chip, ensures that the fixed point of saliva crystallization is formed;Saliva crystalline plateau is formed between two limiting platforms;Saliva crystalline plateau side is connected with handheld platform.
Description
Technical field
The present invention relates to medical detection technology, more particularly to a kind of saliva crystallizes chip.
Background technology
The monitoring ovulation of Women of childbearing age is of great significance for its contraception and standby pregnant demand.Currently, the master of monitoring ovulation
Method is wanted to have basal body temperature method, ovulation test paper method, cervical mucus method, B ultrasound method and saliva crystallisation etc..Wherein basal body temperature method needs
Body temperature before inactive to daily early morning continuously monitors, and troublesome and accuracy rate is low;Ovulation test paper method is easy to operate but interferes
Factor is more, accuracy rate is low;Cervical mucus method and B ultrasound method need hospital by special operation or instrument, and time-consuming, expense
It is high.
Saliva crystallisation is with crystal habit and period consistency possessed by cervical mucus using saliva to female ovulation
The method being monitored.Under different Effect of estrogen, contained protein, sodium chloride and water are a certain proportion of common in saliva
Crystal of different shapes can be formed under effect.7 days or so before ovulation day, fernlike crystal is may occur in which in saliva, until ovulation day
The crystal habit reaches most sturdy, clear and typical, and this structure is tapered small, fuzzy and disappears after ovulation.Market at present
On most saliva crystal type monitoring ovulation product in this, as its testing principle, and be directly coated at slide after saliva acquisition
On, as a result easily by swill and aeration, needs to gargle if feed and take saliva again after waiting for 1 hour, seriously affecting makes
Convenience;The different influences to crystallization effect of salivary pellicle thickness are notable;Simultaneously for image taking type ovulation tests
Instrument, saliva amount and crystallization position are difficult to control, poor in the crystal habit of different location when especially saliva crystal region area is larger
Not huge, the alignment difficulties and reference object alignment function challenge etc. of camera site and target area will directly affect point
Analyse accuracy and user experience.
To sum up, how to need to provide a kind of saliva collection, filtering and the chip of crystallization is that there is an urgent need for solutions by those skilled in the art
Certainly the problem of.
Invention content
In view of this, the present invention provides a kind of salivas to crystallize chip, collection saliva collection, filtering and crystallization function are one
Body effectively improves saliva ovulation tests method, it can be achieved that the universe observation of the crystallization of saliva small area fixed point and saliva crystallization
Practicability and reliability.
A kind of saliva crystallization chip, including filtrating chip and the crystallization chip below the filtrating chip;
The open type saliva collection chamber for saliva quantitative collection and storage is provided on the filtrating chip;The saliva
Collecting chamber bottom is communicated with filter, and the filter can eliminate bubble and food in saliva during saliva displacement
Residue improves the accuracy and observability of saliva crystallization;The filtrating chip is provided at both ends with limited post;
Limiting platform corresponding with the limited post position is provided on the crystallization chip, and in the limiting platform
On be provided with and coordinate with the matched limit hole of the limited post, the limited post and the limit hole, to the filtrating chip and
The relative position of the crystallization chip limits, and ensures that the fixed point of saliva crystallization is formed;Saliva is formed between two limiting platforms
Liquid crystalline plateau;Saliva crystalline plateau side is connected with handheld platform, conveniently takes, and saliva crystallization is prevented to be destroyed.Through
The crystallization chip below the saliva contacts of filtering is simultaneously formed and the filter underside shape one in saliva crystalline plateau
The saliva liquid film of cause, the thickness of the saliva liquid film can utilize the spacing and mistake of the filter lower surface and umbrella-type crystallization chip
The filter time is controlled.
A kind of saliva provided by the invention crystallizes chip, bubble and swill pair when eliminating saliva collection in saliva
The influence of crystallization, while filtered quantitative saliva can be formed in specified region by filter opening and be crystallized, crystallization condition stabilization can
Control, crystallization are easy to observe, and accuracy is high.
Preferably, in a kind of above-mentioned saliva crystallization chip, the filtrating chip and the crystallization chip prepare material
Include but are not limited to polymethyl methacrylate high polymer, N,N-DMAA high polymer, glass, metal;It is described
The cross-sectional shape of filtrating chip and the crystallization chip includes but are not limited to rectangle, circle, sector;The filtrating chip and
The thickness of the crystallization chip is between 0.1mm -5mm.
Preferably, in a kind of above-mentioned saliva crystallization chip, the filtrating chip is to pass through polymethyl methacrylate height
Rectangular parallelepiped structure made of polymers, size are 15mm × 30mm × 0.8mm.
Preferably, in a kind of above-mentioned saliva crystallization chip, the crystallization chip is the cuboid knot made of glass
Structure, size are 15mm × 50mm × 1.0mm.
Preferably, in a kind of above-mentioned saliva crystallization chip, the cross-sectional shape of the saliva collection chamber includes but not only
It is limited to rectangle, circle;The height of the saliva collection chamber is between 0.1mm -10mm.
Preferably, in a kind of above-mentioned saliva crystallization chip, the saliva collection chamber is that cross section is circular cylinder
Chamber, a diameter of 5.0mm are highly 0.5mm.
Preferably, in a kind of above-mentioned saliva crystallization chip, the shape of the filter lower surface includes but are not limited to
Rectangle, circle;The filtration channel length range being arranged on the filter is between 1mm -20mm, the filtering of the filtration channel
Shape of through holes includes but are not limited to rectangular, round;The filter lower surface is with the crystallization chip chamber distance in 0-10mm
Between.
Preferably, in a kind of above-mentioned saliva crystallization chip, the shape of the filter lower surface is the circle of diameter 4.0mm
Shape;The filtering through-hole of the filtration channel length 1.5mm being arranged on the filter, the filtration channel are diameter 0.2mm
Round hole;The distance between the filter lower surface and the crystallization chip are 0.3mm.
It can be seen via above technical scheme that compared with prior art, the present disclosure provides a kind of salivas to crystallize core
Piece, application method are:Filtrating chip and crystallization chip are subjected to position restriction by the combination of limited post and limit hole, utilize hand
Refer to the mode for dipping or directly spitting to be transferred to saliva in saliva collection chamber from oral cavity, saliva is made to be full of the saliva collection chamber, uses
The filtering through-hole that finger gently presses the saliva in saliva collection chamber to make a certain amount of saliva through filtration channel reaches crystallization chip business,
Designated position, which is formed, has certain thickness saliva liquid film, avoids saliva excess diffusion, it is ensured that crystallize the accuracy of detection;It moves
Except the filtrating chip of top, the crystallization chip of lower section is stood, is seen until saliva can be placed in after being completely dried under microscope
It examines.
Saliva provided by the invention crystallization chip cost is cheap, can be used as disposable product, with easy to use and reduce weight
Issuable pollution problem during multiple use, while crystallization chip surface scratch in washing process repeatedly being avoided to cause to observe
Difficult problem;It is reused after can also being washed and dried with clear water.
The present invention can be used for the fixed point of the quantitative collection of saliva, storage, bubble removing, residue filter and filtered fluid
Quantitative crystallization.The influence of bubble and swill to crystallization when eliminating saliva collection in saliva.Filtered quantitative saliva
Crystallization can be formed in specified region by filter opening, crystallization condition is stably and controllable and crystal region is fixed and area is smaller, can be into
Row universe is observed, and resultant error caused by the difference of observation area is avoided.It is used in conjunction with mating observation instrument, ocean weather station observation is not necessarily to
Position and focal length are manually adjusted, it is easy to operate user friendly.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
The cross-sectional view of the structure of Fig. 1 present invention.
The schematic enlarged-scale view of part A in Fig. 2 Fig. 1.
Filter element slice vertical view in Fig. 3 present invention.
Chip vertical view is crystallized in Fig. 4 present invention.
The saliva of Fig. 5 different times of the embodiment of the present invention crystallizes observation chart.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a kind of salivas to crystallize chip, can be used for the quantitative collection of saliva, storage, bubble removing,
The site-directed quantitative of residue filter and filtered fluid crystallizes.Bubble and swill when eliminating saliva collection in saliva
Influence to crystallization.Filtered quantitative saliva can be formed in specified region by filter opening and be crystallized, and crystallization condition is stably and controllable
And crystal region is fixed and area is smaller, can carry out universe observation, avoid resultant error caused by the difference of observation area.In conjunction with
It covers observation instrument to use, ocean weather station observation is easy to operate user friendly without manually adjusting position and focal length.
In conjunction with attached drawing 1-5, chip is crystallized the invention discloses a kind of saliva, including filtrating chip 1 and is located at filtrating chip 1
The crystallization chip 2 of lower section;
The open type saliva collection chamber 3 for saliva quantitative collection and storage is provided on filtrating chip 1;Saliva collection chamber
3 bottoms are communicated with the filter 5 that can eliminate bubble and swill in saliva;Filtrating chip 1 is provided at both ends with limited post 6;
It is provided with limiting platform 7 corresponding with 6 position of limited post on crystallization chip 2, and is provided on limiting platform 7
With 6 matched limit hole 8 of limited post, limited post 6 coordinates with limit hole 8, to the relative position of filtrating chip 1 and crystallization chip 2
It limits, ensures that the fixed point of saliva crystallization is formed;Saliva crystalline plateau 9 is formed between two limiting platforms 7;Saliva crystalline plateau 9
Side is connected with handheld platform 10.
In order to advanced optimize above-mentioned technical proposal, filtrating chip 1 and the material for preparing for crystallizing chip 2 include but not only limit
In polymethyl methacrylate high polymer, N,N-DMAA high polymer, glass, metal;Filtrating chip 1 and crystallization core
The cross-sectional shape of piece 2 includes but are not limited to rectangle, circle, sector [since the shape of filtrating chip and crystallization chip is not
It determines shape, and parameter type of different shapes is different, therefore is only described below for the restriction of parameter of different shapes
Common Parameters are such as:Thickness, height];The thickness of filtrating chip 1 and crystallization chip 2 is between 0.1mm -5mm.
In order to advanced optimize above-mentioned technical proposal, filtrating chip 1 of polymethyl methacrylate high polymer by being made up
Rectangular parallelepiped structure, size be 15mm × 30mm × 0.8mm.
In order to advanced optimize above-mentioned technical proposal, crystallization chip 2 is the rectangular parallelepiped structure made of glass, and size is
15mm×50mm×1.0mm。
In order to advanced optimize above-mentioned technical proposal, the cross-sectional shape of saliva collection chamber 3 include but are not limited to rectangle,
It is round;The height of saliva collection chamber 3 is between 0.1mm -10mm.
In order to advanced optimize above-mentioned technical proposal, saliva collection chamber 3 is that cross section is circular cylindrical chamber, diameter
It is highly 0.5mm for 5.0mm.
In order to advanced optimize above-mentioned technical proposal, the shape of 5 lower surface of filter includes but are not limited to rectangle, circle
Shape;Between 1mm -20mm, 4 shape of filtering through-hole of filtration channel includes the filtration channel length range being arranged on filter 5
But it is not limited only to rectangular, round;Distance is between 0-10mm between 5 lower surface of filter and crystallization chip 2.
In order to advanced optimize above-mentioned technical proposal, the shape of 5 lower surface of filter is the circle of diameter 4.0mm;Filtering
The filtration channel length 1.5mm being arranged on device 5, filtration channel filter the round hole that through-hole 4 is diameter 0.2mm;Under filter 5
The distance between surface and crystallization chip 2 are 0.3mm.
In conjunction with attached drawing 5, saliva crystalline state is related to physiological period, and 7 days or so before ovulation day, sheep is may occur in which in saliva
Dentation crystallizes, until the ovulation day crystal habit reaches most sturdy, clear and typical, this structure is tapered small, mould after ovulation
It pastes and disappears, saliva crystalline state can undergo cyclically-varying, mistake of the big small fern-of fern-without the big fern of the small fern-of fern-
Journey.
Each embodiment is described by the way of progressive in this specification, the highlights of each of the examples are with other
The difference of embodiment, just to refer each other for identical similar portion between each embodiment.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so description is fairly simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (8)
1. a kind of saliva crystallizes chip, which is characterized in that including filtrating chip (1) and below the filtrating chip (1)
Crystallize chip (2);
The open type saliva collection chamber (3) for saliva quantitative collection and storage is provided on the filtrating chip (1);The saliva
Liquid collecting chamber (3) bottom is communicated with the filter (5) that can eliminate bubble and swill in saliva;The filtrating chip (1)
It is provided at both ends with limited post (6);
Limiting platform (7) corresponding with the limited post (6) position is provided on the crystallization chip (2), and in the limit
It is provided on bit platform (7) and the limited post (6) matched limit hole (8), the limited post (6) and the limit hole (8)
Cooperation limits the relative position of the filtrating chip (1) and the crystallization chip (2), ensures that the fixed point of saliva crystallization is formed;
Saliva crystalline plateau (9) is formed between two limiting platforms (7);Saliva crystalline plateau (9) side is connected with hand-held
Platform (10).
2. a kind of saliva according to claim 1 crystallizes chip, which is characterized in that the filtrating chip (1) and the knot
The material for preparing of brilliant chip (2) includes but are not limited to polymethyl methacrylate high polymer, N,N-DMAA height
Polymers, glass, metal;The cross-sectional shape of the filtrating chip (1) and the crystallization chip (2) includes but are not limited to square
Shape, circle, sector;The thickness of the filtrating chip (1) and the crystallization chip (2) is between 0.1mm -5mm.
3. a kind of saliva according to claim 2 crystallizes chip, which is characterized in that the filtrating chip (1) is by poly-
Rectangular parallelepiped structure made of methyl methacrylate high polymer, size are 15mm × 30mm × 0.8mm.
4. a kind of saliva according to claim 2 crystallizes chip, which is characterized in that the crystallization chip (2) is to pass through glass
Rectangular parallelepiped structure made of glass, size are 15mm × 50mm × 1.0mm.
5. a kind of saliva according to claim 1 crystallizes chip, which is characterized in that the saliva collection chamber (3) it is transversal
Face shape includes but are not limited to rectangle, circle;The height of the saliva collection chamber (3) is between 0.1mm -10mm.
6. a kind of saliva according to claim 5 crystallizes chip, which is characterized in that the saliva collection chamber (3) is transversal
Face is circular cylindrical chamber, and a diameter of 5.0mm is highly 0.5mm.
7. a kind of saliva according to claim 1 crystallizes chip, which is characterized in that the shape of filter (5) lower surface
Shape includes but are not limited to rectangle, circle;The filtration channel length range being arranged on the filter (5) 1mm -20mm it
Between, filtering through-hole (4) shape of the filtration channel includes but are not limited to rectangular, round;Filter (5) lower surface with
Distance is between 0-10mm between the crystallization chip (2).
8. a kind of saliva according to claim 7 crystallizes chip, which is characterized in that the shape of filter (5) lower surface
Shape is the circle of diameter 4.0mm;The filtration channel length 1.5mm being arranged on the filter (5), the filtration channel
Filter the round hole that through-hole (4) is diameter 0.2mm;The distance between filter (5) lower surface and the crystallization chip (2)
For 0.3mm.
Priority Applications (1)
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CN201810917074.XA CN108761053B (en) | 2018-08-13 | 2018-08-13 | Saliva crystallization chip |
Applications Claiming Priority (1)
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CN201810917074.XA CN108761053B (en) | 2018-08-13 | 2018-08-13 | Saliva crystallization chip |
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CN108761053B CN108761053B (en) | 2024-07-09 |
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2018
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CA2275383A1 (en) * | 1996-12-20 | 1997-07-03 | Karen Pamela Orell-Porrazzo | Positive fertility testing and reproductive health system |
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