CN108744265B - Closed positive pressure joint - Google Patents

Closed positive pressure joint Download PDF

Info

Publication number
CN108744265B
CN108744265B CN201810510583.0A CN201810510583A CN108744265B CN 108744265 B CN108744265 B CN 108744265B CN 201810510583 A CN201810510583 A CN 201810510583A CN 108744265 B CN108744265 B CN 108744265B
Authority
CN
China
Prior art keywords
valve core
liquid medicine
inner cavity
fixed column
sealing slit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201810510583.0A
Other languages
Chinese (zh)
Other versions
CN108744265A (en
Inventor
陈志秋
韦乃武
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Maiwei Biotechnology Co ltd
Original Assignee
Shenzhen Maiwei Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Maiwei Biotechnology Co ltd filed Critical Shenzhen Maiwei Biotechnology Co ltd
Priority to CN201810510583.0A priority Critical patent/CN108744265B/en
Publication of CN108744265A publication Critical patent/CN108744265A/en
Application granted granted Critical
Publication of CN108744265B publication Critical patent/CN108744265B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/14Tube connectors; Tube couplings for connecting tubes having sealed ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/2433Valve comprising a resilient or deformable element, e.g. flap valve, deformable disc

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The utility model discloses a closed positive pressure connector, which comprises a valve body with a hollow inner cavity, a reset body and a valve core, wherein the inner cavity comprises a liquid medicine channel, the top of the inner cavity is an upper interface end, the bottom of the inner cavity is provided with a lower interface end, the liquid medicine channel is communicated with the lower interface end, the reset body is fixed inside the inner cavity, the valve core is elastically supported inside the inner cavity by the reset body and seals the upper interface end, the valve core is provided with an elastic normally closed sealing slit, the sealing slit is positioned above the liquid medicine channel, the valve core is provided with an initial state and an infusion state, and the sealing slit is closed in the initial state; in the infusion state, the sealing slit is opened, and an infusion connector can enter the inner cavity from the sealing slit and be communicated with the liquid medicine channel. Through setting up normally closed seal slit, can prevent effectively that liquid medicine from spilling, stop bacterium or dust to get into the liquid medicine passageway and cause the liquid medicine pollution.

Description

Closed positive pressure joint
Technical Field
The utility model relates to the field of medical equipment, in particular to a closed positive pressure joint.
Background
The Chinese patent with the name of 'medical needleless positive pressure connector' and the publication number of CN202605411U discloses a medical needleless positive pressure connector, when in transfusion, an infusion set connector is propped against the upper end face of a valve core to press down the valve core, when the valve core and a return spring are positioned at the lower limit position, the infusion set connector is communicated with a clearance cavity to perform transfusion, and the infusion set connector moves upwards and out of the medical needleless positive pressure connector after one transfusion is finished, however, in the process, the return spring can apply larger upward force to the infusion set connector through the valve core, at the moment, if an operator carelessly does not hold the infusion set connector, the infusion set connector is easily and directly popped up by the valve core, so that residual liquid medicine in the infusion set connector is splashed out to cause waste. In addition, external bacteria or dust can enter the inner cavity of the medical needleless positive pressure connector through the water inlet to pollute the liquid medicine.
It is thus seen that it is necessary to design a new positive medical pressure fitting.
Disclosure of Invention
The utility model provides a novel closed positive pressure joint.
The utility model provides a closed positive pressure connector, which comprises a valve body with a hollow inner cavity, a reset body and a valve core, wherein the inner cavity comprises a liquid medicine channel, the top of the inner cavity is an upper interface end, the bottom of the inner cavity is provided with a lower interface end, the liquid medicine channel is communicated with the lower interface end, the reset body is fixed inside the inner cavity, the valve core is elastically supported inside the inner cavity by the reset body and seals the upper interface end, the valve core is provided with an elastic normally closed sealing slit, the sealing slit is positioned above the liquid medicine channel, the valve core is provided with an initial state and an infusion state, and the sealing slit is closed in the initial state; in the infusion state, the sealing slit is opened, and an infusion connector can enter the inner cavity from the sealing slit and be communicated with the liquid medicine channel.
In the initial state, the sealing slit is closed under the action of self elastic force. When the infusion connector is disassembled, the valve core is reset under the action of the reset body, and the sealing slit is also reset to be closed under the action of self elastic force. The restoring body may be a spring or other structure capable of providing an elastic force.
The valve core can seal the upper interface end in both the initial state and the infusion state.
The upper interface end is a liquid inlet end which can be connected with an infusion connector. The lower interface end is a liquid outlet end which can be connected with medical instruments, such as various medical liquid medicine connecting pipelines.
The inner cavity is provided with a fixed column extending in the axial direction of the valve body, the liquid medicine channel vertically penetrates through the fixed column, the reset body is sleeved on the lower portion of the fixed column, and the valve core is sleeved on the upper portion of the fixed column and is in sliding fit with the fixed column.
The upper portion of fixed column is equipped with radial through-hole that runs through, the through-hole with the liquid medicine passageway intercommunication. The axis of the through hole and the axis of the fixed column are usually included with an acute angle, i.e. the through hole is inclined downwards.
The valve core comprises an upper valve core which is soft and elastic and a lower valve core which is hard, the sealing slit is arranged on the upper valve core, a matching cavity is formed by upwards recessing from the bottom surface of the lower valve core, and the upper part of the fixing column upwards stretches into the matching cavity.
The valve body comprises an upper shell and a base, wherein the upper shell surrounds the inner cavity, the upper shell is fixed on the top surface of the base, the fixing column extends upwards from the top surface of the base, the liquid medicine channel penetrates through the top surface of the fixing column and the bottom surface of the base, and the lower interface end extends downwards from the bottom surface of the base.
The utility model provides a closed malleation connects, includes upper housing, base, spring and case, runs through from top to bottom the upper housing forms the shell chamber, the top of shell chamber is equipped with the upper interface end, the bottom of shell chamber with the top surface of base is fixed, upwards extends the fixed column from the top surface of base, the fixed column upwards stretches into the shell intracavity, runs through the top surface of fixed column and the bottom surface of base form the liquid medicine passageway, downwards extends the lower interface end from the bottom surface of base, liquid medicine passageway and lower interface end intercommunication, the spring cover is in the lower part of fixed column, the case cover is in the upper portion of fixed column, the case has elasticity normally closed seal slit, seal slit is located the top of liquid medicine passageway in the initial state, seal slit is closed; in the infusion state, the sealing slit is opened, and an infusion connector can enter the inner cavity from the sealing slit and be communicated with the liquid medicine channel.
The shell cavity can comprise a conical first shell cavity with a small inner diameter and a large inner diameter and a cylindrical second shell cavity with an equal inner diameter, and a horizontal step surface is formed at the joint of the first shell cavity and the second shell cavity.
The valve core comprises an upper valve core which is soft and elastic and a lower valve core which is hard, the sealing slit is arranged on the upper valve core, a matching cavity is formed by upwards recessing from the bottom surface of the lower valve core, and the top of the fixing column upwards stretches into the matching cavity.
The beneficial effects of the utility model are as follows: the normally closed sealing slit is arranged, so that the liquid medicine can be effectively prevented from splashing, and bacteria or dust can be prevented from entering the liquid medicine channel to pollute the liquid medicine.
Drawings
Fig. 1 is an exploded perspective view of a sealed positive pressure joint according to the present embodiment;
fig. 2 is a schematic plan view of the valve body of the sealed positive pressure joint according to the present embodiment;
fig. 3 is a schematic cross-sectional view of the closed positive pressure joint of the present embodiment;
fig. 4 is an enlarged partial schematic view of the portion indicated by a in fig. 3.
Detailed Description
The utility model will be described in further detail below with reference to the drawings by means of specific embodiments.
As shown in fig. 1 to 4, the sealed positive pressure joint of the present embodiment includes an upper case 1, a rubber stopper 2, a spring 3, and a base 4. The upper shell 1 is provided with a screw thread end 11, and the screw thread end 11 can be connected with other pipeline joints or equipment joints to convey liquid medicine. The bottom of the upper shell 1 is provided with a first positioning step 12 which can be assembled with the base. The rubber plug 2 is arranged in the upper shell, and can automatically open the normally closed sealing slit 21 after being pushed inwards, so that the rubber plug is communicated with the base to convey liquid medicine. The spring 3 is arranged on the base and has elastic force, and can elastically reset the rubber plug 2 to enable the rubber plug to achieve a sealing function. The base 4 is provided with a connector tube 41, the connector tube 41 can be connected by a connecting pipeline, a second positioning step 42 is arranged at the position of the base 4 corresponding to the first positioning step 12, and the first positioning step 12 and the second positioning step 42 are matched in a positioning way, so that the base 4 and the upper shell 1 are assembled integrally.
In the present embodiment, the upper case 1 and the base 4 are integrally fixed to form a valve body having a hollow cavity 13, the screw thread end 11 is provided at the top of the cavity as an upper interface end for connecting to an infusion set, and the interface tube 41 is provided at the bottom of the cavity as a lower interface end for connecting to a medical device for receiving a medical fluid. The lumen 13 may include a medical fluid passageway 14. The rubber plug 2 is elastically supported inside the inner cavity 13 by the spring 3 and closes the top opening of the inner cavity, and the sealing slit 21 of the rubber plug is positioned above the liquid medicine channel 14.
In the present embodiment, in the initial state, the seal slit 21 is closed by the self elastic force. In the infusion state, the infusion connector is inserted into the sealed positive pressure connector, and the infusion connector can pass through the sealing slit 21 and then be communicated with the liquid medicine channel 14, and in the process, the infusion connector drives the rubber plug 2 to move downwards. When the infusion connector is detached, the sealing slit 21 is restored to the original state to be closed again, and the rubber stopper 2 is restored to the original state under the action of the elastic force of the spring.
In this embodiment, the rubber plug has elasticity and is installed inside the upper case, and its cross section may be circular or square. The spring may have elasticity and a circular or square cross section, and is mounted to the base.
As shown in fig. 1 to 4, the sealed positive pressure joint of the present embodiment includes an upper case 1, a rubber stopper 2, a spring 3, and a base 4. The upper shell 1 and the base 4 are fixed integrally to form a valve body with a hollow inside, the rubber plug 2 is elastically supported inside the valve body through the spring 3, and the rubber plug 2 can seal the top opening of the valve body. The positive pressure connector has an initial state and an infusion state, in which the valve core closes the top opening of the valve body.
The base 4 has a top surface 43 and a bottom surface 44 opposite to each other, a fixing post 45 extends upward from a central position of the top surface 43, a second positioning step 42 extends upward from an edge position of the top surface, and a height of the fixing post 45 is greater than a height of the second positioning step 42. A liquid medicine passage 14 is formed through the top surface of the fixing post and the bottom surface of the base. A port tube 41 extends downwards from the central position of the bottom surface of the base, and the port tube 41 is communicated with the liquid medicine channel 14.
The top of the upper shell 1 is provided with a screw end 11 which can be connected with other pipeline joints or equipment joints to convey liquid medicine. The bottom of the upper case 1 is provided with a first positioning step 12. And in the axial direction of the positive pressure joint, the upper shell penetrates through the lower shell to form a shell cavity. The shell cavity comprises a first shell cavity 15 and a second shell cavity 16 which are communicated with each other, a horizontal step surface 17 is formed at the joint of the first shell cavity 15 and the second shell cavity 16, and the second shell cavity 16 is positioned below the first shell cavity 15. The second housing cavity 16 may be a cylindrical housing cavity having the same inner diameter. The inner diameter of the first shell cavity 15 can be changed, and in the axial direction of the positive pressure joint, the inner diameter of the first shell cavity 15 is increased from top to bottom, so that the first shell cavity can be approximately conical with the inner diameter smaller from top to bottom.
The rubber stopper 2 includes an upper rubber stopper 22 made of a soft and elastic material and a lower rubber stopper 23 made of a harder material. A matching cavity 24 with a bottom is formed upwards from the central position of the bottom surface of the lower rubber plug, a normally closed sealing slit 21 is formed downwards from the central position of the top surface of the upper rubber plug, and a flange 25 horizontally extends from the side surface of the bottom of the lower rubber plug.
The fixing column 45 has a radially penetrating hole 46 at an upper portion thereof, and the penetrating hole 46 communicates with the chemical liquid passage 14. The axis of the through hole and the axis of the fixed column form an included angle with an acute angle, namely, the through hole is arranged obliquely downwards. The upper part of the fixing column 45 extends upwards into the matching cavity 24 of the rubber plug, and accumulated liquid in the matching cavity 24 can flow back to the liquid medicine channel 14 through the through hole 46.
During assembly, the second positioning step 42 of the base 4 is matched with the first positioning step 12 of the upper shell in a positioning way, and the upper shell and the base are fixed integrally to form a valve body; the spring 3 is sleeved on the fixed column 45, the bottom of the spring 3 is connected with the bottom of the second shell cavity (namely the top surface of the base), and the rubber plug 4 is arranged on the top of the spring 3. In the initial state, the sealing slit 21 is closed, the rubber plug 2 blocks the top opening of the valve body under the action of the elastic force of the spring, at the moment, the flange 25 of the rubber plug props against the step surface 17 of the valve body, and the side surfaces of the upper rubber plug and the lower rubber plug are in sealing fit with the cavity walls of the first shell cavity and the second shell cavity. After the infusion connector is connected, the sealing slit is opened, and the rubber plug is pressed down by the infusion connector.
In this embodiment, the valve body has the cavity inner chamber, and the inner chamber includes the liquid medicine passageway, and liquid medicine passageway and interface tube intercommunication, the top opening of plug closed inner chamber, the normally closed sealed slit of plug are located liquid medicine passageway top, and infusion connects can pass the sealed slit after with liquid medicine passageway intercommunication. The rubber plug is used as a valve core to seal the top opening of the inner cavity of the valve body, and the rubber plug can be replaced by other materials and structures which can achieve good sealing effect.
The foregoing is a further detailed description of the utility model in connection with specific embodiments, and it is not intended that the utility model be limited to such description. It will be apparent to those skilled in the art that several simple deductions or substitutions can be made without departing from the spirit of the utility model.

Claims (3)

1. The sealed positive pressure connector is characterized by comprising a valve body with a hollow inner cavity, a reset body and a valve core, wherein the inner cavity comprises a liquid medicine channel, the top of the inner cavity is an upper interface end, the bottom of the inner cavity is provided with a lower interface end, the liquid medicine channel is communicated with the lower interface end, the reset body is fixed inside the inner cavity, the valve core is elastically supported inside the inner cavity by the reset body and seals the upper interface end, the valve core is provided with an elastic normally closed sealing slit, the sealing slit is positioned above the liquid medicine channel, the valve core is provided with an initial state and an infusion state, and the sealing slit is closed in the initial state; in the infusion state, the sealing slit is opened, and the infusion connector can enter the inner cavity from the sealing slit and is communicated with the liquid medicine channel; the inner cavity is provided with a fixed column extending in the axial direction of the valve body, the liquid medicine channel vertically penetrates through the fixed column, the reset body is sleeved on the lower part of the fixed column, and the valve core is sleeved on the upper part of the fixed column and is in sliding fit with the fixed column; the valve core comprises an upper valve core which is made of soft and elastic materials and a lower valve core which is made of hard materials, the sealing slit is formed in the upper valve core, a matching cavity is formed by upwards recessing from the bottom surface of the upper valve core, and the upper part of the fixing column upwards extends into the matching cavity; the upper portion of fixed column is equipped with radial through-hole that runs through, the axis of through-hole with the axis of fixed column has the contained angle that is the acute angle, the through-hole with the liquid medicine passageway intercommunication.
2. The positive pressure sealed joint according to claim 1, wherein the valve body includes an upper case and a base surrounding the inner cavity, the upper case is fixed to a top surface of the base, the fixing column extends upward from the top surface of the base, the liquid medicine passage penetrates through the top surface of the fixing column and a bottom surface of the base, and the lower interface end extends downward from the bottom surface of the base.
3. The sealed positive pressure connector is characterized by comprising an upper shell, a base, a spring and a valve core, wherein the upper shell penetrates through the upper shell from top to bottom to form a shell cavity, an upper interface end is arranged at the top of the shell cavity, the bottom of the shell cavity is fixed with the top surface of the base, a fixed column extends upwards from the top surface of the base and stretches into the shell cavity, a liquid medicine channel is formed through the top surface of the fixed column and the bottom surface of the base, a lower interface end extends downwards from the lower bottom surface of the base, the liquid medicine channel is communicated with the lower interface end, the spring is sleeved at the lower part of the fixed column, the valve core is sleeved at the upper part of the fixed column, the valve core is provided with an elastic normally closed sealing slit, and the sealing slit is positioned above the liquid medicine channel and is closed in an initial state; in the infusion state, the sealing slit is opened, and the infusion connector can enter the inner cavity from the sealing slit and is communicated with the liquid medicine channel; the valve core comprises an upper valve core which is made of soft and elastic materials and a lower valve core which is made of hard materials, the sealing slit is formed in the upper valve core, a matching cavity is formed by upwards recessing from the bottom surface of the lower valve core, and the upper part of the fixing column upwards extends into the matching cavity; the upper portion of fixed column is equipped with radial through-hole that runs through, the axis of through-hole with the axis of fixed column has the contained angle that is the acute angle, the through-hole with the liquid medicine passageway intercommunication.
CN201810510583.0A 2018-05-24 2018-05-24 Closed positive pressure joint Active CN108744265B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810510583.0A CN108744265B (en) 2018-05-24 2018-05-24 Closed positive pressure joint

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810510583.0A CN108744265B (en) 2018-05-24 2018-05-24 Closed positive pressure joint

Publications (2)

Publication Number Publication Date
CN108744265A CN108744265A (en) 2018-11-06
CN108744265B true CN108744265B (en) 2024-01-09

Family

ID=64005851

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810510583.0A Active CN108744265B (en) 2018-05-24 2018-05-24 Closed positive pressure joint

Country Status (1)

Country Link
CN (1) CN108744265B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912664A (en) * 2010-05-21 2010-12-15 成都普什医药塑料包装有限公司 Disposable positive pressure joint
CN204307139U (en) * 2014-11-18 2015-05-06 深圳市安特高科实业有限公司 Closed positive pressure connector
CN204307149U (en) * 2014-11-18 2015-05-06 深圳市安特高科实业有限公司 Closed positive pressure remaining needle
JP2016106958A (en) * 2014-12-09 2016-06-20 ニプロ株式会社 Needleless connector

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013121769A1 (en) * 2012-02-13 2013-08-22 二プロ株式会社 Needle-less connector

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912664A (en) * 2010-05-21 2010-12-15 成都普什医药塑料包装有限公司 Disposable positive pressure joint
CN204307139U (en) * 2014-11-18 2015-05-06 深圳市安特高科实业有限公司 Closed positive pressure connector
CN204307149U (en) * 2014-11-18 2015-05-06 深圳市安特高科实业有限公司 Closed positive pressure remaining needle
JP2016106958A (en) * 2014-12-09 2016-06-20 ニプロ株式会社 Needleless connector

Also Published As

Publication number Publication date
CN108744265A (en) 2018-11-06

Similar Documents

Publication Publication Date Title
US8298195B2 (en) Needleless access port valve
JP4238137B2 (en) Wipeable slit valve
KR102323747B1 (en) Valved connector for medical lines
US5569235A (en) Valve and valved container for use with a syringe fitting
US7314061B2 (en) Needleless access port valves
US6569117B1 (en) Blood sampling/injecting valve
US20060197045A1 (en) Needleless access port valves
WO2018095267A1 (en) Washing machine faucet and washing machine
JP7124254B2 (en) Laundry additive case and washing machine
JPS6341613B2 (en)
JP2012024565A (en) Connector
CN108744265B (en) Closed positive pressure joint
KR101343697B1 (en) Spuit type vessel cap to prevent from flowing backward
CN201768229U (en) Automatic hydraulic control opened and closed infusion apparatus and hydraulic control opening and closing mechanism and hydraulic control opening and closing valve thereof
CN209405486U (en) Closed positive pressure connector
CN108758927B (en) humidifier
CN108452434B (en) Multiple unidirectional airtight joint and pipeline device
KR20150044869A (en) Tube vessel for cosmetic
CN217737408U (en) Detachable water tank structure and air humidity adjusting device
CN210949884U (en) Injection device and injection system
CN213308836U (en) Push type bowl cover and drinking cup
CN216932775U (en) Novel water dispenser bottled water clever seat structure
CN209900846U (en) Filter element seat of water purifier
CN212407049U (en) Water pump head
KR101909584B1 (en) Device for Sealing and Injecting the Inlet of Container

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant