CN108744058A - A kind of degradable synthetism stick implantation instrument and preparation method thereof - Google Patents
A kind of degradable synthetism stick implantation instrument and preparation method thereof Download PDFInfo
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- CN108744058A CN108744058A CN201810681147.XA CN201810681147A CN108744058A CN 108744058 A CN108744058 A CN 108744058A CN 201810681147 A CN201810681147 A CN 201810681147A CN 108744058 A CN108744058 A CN 108744058A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/024—Anodisation under pulsed or modulated current or potential
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/026—Anodisation with spark discharge
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/30—Anodisation of magnesium or alloys based thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The present invention provides a kind of degradable synthetism stick implantation instruments, including degradable medical synthetism stick and the coating for being compound in Medical bone stick surface；The Medical bone stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：The Mg of the Sr and surplus of Fe more than 0 and less than or equal to 0.5wt%, the Zn more than 0 and less than or equal to 1wt%, the Mn more than 0 and less than or equal to 0.6wt%, Cu, 0.8wt% more than 0 and less than or equal to 0.05wt%；The coating is Ca-P-Ag coatings.Present invention also provides the preparation methods of degradable synthetism stick implantation instrument.Material of main part of the application by using pure magnesium material or magnesium alloy materials as degradable synthetism stick implantation instrument, and pass through the Ca-P-Ag coating compound in bulk material surface, degradable synthetism stick implantation instrument is set to can induce new Bone Ingrowth, reconstruction of bone tissue achievees the purpose that repairing bone defect.
Description
Technical field
The present invention relates to medical bio implantation field of material technology more particularly to a kind of degradable synthetism stick implantation instrument and
Preparation method.
Background technology
Bio-medical material is for its disease damage tissue, organ or increasing is diagnosed, treated, repaired or replaced to organism
Into the material of its function；It is the basis for studying artificial organs and medical instrument, it has also become the important branch of current material subject,
It has become scientists from all over the world especially with booming and important breakthrough, the bio-medical material of biotechnology and competitively grinds
The hot spot studied carefully and developed.
Bio-medical material can be divided into the bonemuscle systems repair materials such as bone, tooth, joint, tendon by purposes, skin,
The soft-tissue materials such as breast, esophagus, respiratory tract, bladder, the cardiovascular systems commons such as heart valve film, blood vessel, cardiovascular interpolation pipe
Material, membrane for purifying blood and seperation film, gas-selectively are through medical film materials, tissue adhesive and seams such as film, contact lens
Wire material, drug release carrier material, clinical diagnosis and biosensor material, dental material etc..In above-mentioned bio-medical material
In material, bonemuscle system repair materials are the materials of commonplace application, and especially bone implantation instrument is in such biology doctor
It is used widely in material.
Biomedical metallic material is used as the metal or alloy of bio-medical material, also known as surgery metal material or doctor
It is a kind of inert material with metal material.Main problem in medical metal material application be corrosion due to physiological environment and
Caused by metal ion to surrounding tissue spread and be implanted into material self property regression, the former may lead to toxic side effect, after
Person frequently results in the failure of implantation.Synthetism biomedical metallic material is used to connect the both ends of knochenbruch, or is implanted into
Bone defect part；To achieve the goals above, it is desirable to provide a kind of new medical is implanted into material for synthetism, reaches reparation bone
The purpose of defect.
Invention content
Present invention solves the technical problem that being to provide a kind of degradable synthetism stick implantation instrument, which plants
Enter instrument can reconstruction of bone tissue, achieve the purpose that repair bone injury.
In view of this, this application provides a kind of degradable synthetism stick implantation instrument, including degradable medical synthetism stick with
It is compound in the coating on the degradable medical synthetism stick surface；
The degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：More than 0
And less than or equal to the Fe of the 0.5wt%, Zn more than 0 and less than or equal to 1wt%, the Mn more than 0 and less than or equal to 0.6wt%, big
In the 0 and Mg of the Sr and surplus of Cu, 0.8wt% less than or equal to 0.05wt%；
The coating is Ca-P-Ag coatings.
Preferably, the degradable medical synthetism stick includes coaxially connected pedestal and cylinder, and the diameter of the pedestal is big
In the diameter of the cylinder, and the bottom center setting of the pedestal is fluted.
Preferably, the ratio of the diameter of the diameter of the pedestal and the cylinder is 4:3~2:1, the height of the pedestal
Ratio with the height of the cylinder is (0.8~2):1.
Preferably, the ratio of the length of the diameter of the pedestal and the groove is 1:(0.4~0.8), the pedestal
The ratio of height and the height of the groove is (3~8):1.
Preferably, in the Ca-P-Ag coatings, the content of Ag is no more than 0.1wt%, and surplus is Ca and P.
Preferably, the mass ratio of the Ca and P is 5:3.
Preferably, the thickness of the Ca-P-Ag coatings is more than 0 and is less than or equal to 0.5mm.
Present invention also provides the preparation methods of the degradable synthetism stick implantation instrument, include the following steps：
Ca-P-Ag coatings are grown in degradable medical synthetism stick surface in situ using micro-arc oxidation process；
The degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：More than 0
And less than or equal to the Fe of the 0.5wt%, Zn more than 0 and less than or equal to 1wt%, the Mn more than 0 and less than or equal to 0.6wt%, big
In the 0 and Mg of the Sr and surplus of Cu, 0.8wt% less than or equal to 0.05wt%；
The coating is Ca-P-Ag coatings.
Preferably, the electrolyte in the micro-arc oxidation process is made of following compositions：Sodium metasilicate, the 50wt% of 40wt%
Nanometer hydroxyapatite powder, the sodium fluoride of 5wt%, the glycerine of >=2wt%, the sodium hydroxide of 2wt% ,≤1wt% receive
Rice Ag powder and 2000mL deionized waters.
Preferably, the constant voltage of the differential arc oxidation is 250~400V；Pulse frequency is 300~400Hz；Duty ratio
It is 10~15%, 20~30min of oxidization time.
This application provides a kind of degradable synthetism stick implantation instruments, by degradable medical synthetism stick and are compound in described
The coating on degradable medical synthetism stick surface forms, wherein degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, institute
It is Ca-P-Ag coatings to state coating.Degradable synthetism stick implantation instrument provided by the present application is used to connect both ends or the implantation of knochenbruch
Bone defect part, due to main part degradable medical synthetism stick be pure magnesium material or magnesium alloy materials, then degrade after magnesium from
Son induces new Bone Ingrowth, reconstruction of bone tissue to repair bone injury；Further, be conducive to health and life due to being added
The Ca-P-Ag coatings of class bone composition are contained on essential trace element-iron, zinc, manganese, copper, strontium and surface so that bone tissue has good
Good regeneration function effect.
Description of the drawings
Fig. 1 is the photo in kind of degradable synthetism stick implantation instrument provided by the invention；
Fig. 2 is the sectional view of degradable synthetism stick implantation instrument provided by the invention；
Fig. 3 is the 3 months HE stained photographs in magnesium alloy synthetism stick implanted femur distal end that the embodiment of the present invention 1 provides；
Fig. 4 is the 3 months HE stained photographs in magnesium alloy synthetism stick implanted femur distal end that the embodiment of the present invention 2 provides；
Fig. 5 is the 3 months HE stained photographs in magnesium alloy synthetism stick implanted femur distal end that the embodiment of the present invention 3 provides.
Specific implementation mode
For a further understanding of the present invention, the preferred embodiment of the invention is described with reference to embodiment, still
It should be appreciated that these descriptions are only the feature and advantage further illustrated the present invention, rather than to the claims in the present invention
Limitation.
In order to match the specific requirement of different implant sites, especially stress size, Bone density and implantation environment
Influence, this application provides a kind of degradable synthetism stick implantation instrument, this kind of degradable synthetism stick implantation instrument can induce new
Bone Ingrowth, reconstruction of bone tissue, repairing bone defect.Specifically, the embodiment of the invention discloses a kind of degradable synthetism stick implanting devices
Tool, including degradable medical synthetism stick and the coating for being compound in the degradable medical synthetism stick surface；
The Medical bone stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：More than 0 and it is less than
Zn equal to the Fe of 0.5wt%, more than 0 and less than or equal to 1wt%, the Mn more than 0 and less than or equal to 0.6wt%, it is more than 0 and small
In the Sr of Cu, 0.8wt% equal to 0.05wt% and the Mg of surplus；
The coating is Ca-P-Ag coatings.
Degradable synthetism stick implantation instrument provided by the present application is by Medical bone stick and is compound in the Medical bone stick table
The coating in face forms；Specifically, the Medical bone stick is pure magnesium material or magnesium alloy materials, for pure magnesium material, it can pass through
Magnesium ion after degradation induces new Bone Ingrowth；Further, due to implant site difference, the size withstood forces and implantation
Partial bone tissue microenvironment is different, and herein described degradable medical synthetism stick can also be magnesium alloy materials, the magnesium alloy
Material specifically includes：Fe more than 0 and less than or equal to 0.5wt%, the Zn more than 0 and less than or equal to 1wt%, more than 0 and it is less than
The Mg of the Sr and surplus of Mn equal to 0.6wt%, Cu, 0.8wt% more than 0 and less than or equal to 0.05wt%；Due to adding
Iron, zinc, manganese, copper and this kind of essential trace element for being conducive to health and life of strontium, make bone tissue have good regeneration
Function；Above-mentioned trace element can improve the intensity of Medical bone stick simultaneously, make have suitable degradation rate in degradation process, with
Match the knitting required time.In a particular embodiment, the content of the Fe is 0.08~0.40wt%, and the Zn's contains
Amount is 0.15~0.80wt%, and the content of the Mn is 0.12~0.54wt%, the content of the Cu is 0.012~
0.039wt%.The content of described Fe, Zn, Mn, Cu and Sr exceed above range, then degradable synthetism stick implantation instrument biofacies
Capacitive is poor.
The both ends of detachment bone, herein described degradable medical synthetism are connected for the ease of degradable synthetism stick implantation instrument
Stick includes coaxially connected pedestal and cylinder, and the diameter of the pedestal is more than the diameter of the cylinder, and the bottom of the pedestal
Center setting is fluted.Specifically, Fig. 1 is the photo in kind of degradable synthetism stick implantation instrument provided by the invention, figure a) is
It is b) reality of degradable synthetism stick implantation instrument composite coating that degradable synthetism stick implantation instrument, which does not have cated photo in kind, figure,
Object photo；Fig. 2 is the sectional view of degradable synthetism stick implantation instrument provided by the invention.For this kind of Medical bone stick its pedestal
Diameter and the cylinder diameter ratio be 4:3~2:1, the ratio of the height of the height of the pedestal and the cylinder is
(0.8~2):1；The ratio of the length of the diameter of the pedestal and the groove is 1：(0.4~0.8), the height of the pedestal
Ratio with the height of the groove is (3~8):1.In actual application, can be adjusted according to specific application environment can
The size of degradation Medical bone stick.
According to the present invention, the degradable medical synthetism stick surface recombination has Ca-P-Ag coatings, the coating have antibacterial,
The effect of class bone, in favor of the regeneration of bone tissue.Specifically, the Ca-P-Ag coatings are the calcium phosphorus compositions formed containing class bone
With the nanometer Ag coating of antibacterial functions；Wherein the content of Ag is no more than 0.1wt%, and surplus is Ca and P, more specifically, the Ca
Mass ratio with P is 5:3.The thickness of the Ca-P-Ag coatings is more than 0 and is less than or equal to 0.5mm.
Present invention also provides the preparation methods of the degradable synthetism stick implantation instrument, include the following steps：
Ca-P-Ag coatings are grown in degradable medical synthetism stick surface in situ using micro-arc oxidation process；
The degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：More than 0
And less than or equal to the Fe of the 0.5wt%, Zn more than 0 and less than or equal to 1wt%, the Mn more than 0 and less than or equal to 0.6wt%, big
In the 0 and Mg of the Sr and surplus of Cu, 0.8wt% less than or equal to 0.05wt%；
The coating is Ca-P-Ag coatings.
During preparing degradable synthetism stick implantation instrument, the application is by micro-arc oxidation process in Medical bone stick
Surface is prepared for Ca-P-Ag coatings；The Medical bone stick is prepared according to method well known to those skilled in the art, to this this Shen
It please be not particularly limited.The micro-arc oxidation process is a kind of technique well known to those skilled in the art, is in alloy table
The TRANSIENT HIGH TEMPERATURE high pressure effect that face is generated by arc discharge, growth in situ go out the ceramic membrane based on substrate metal oxide
Layer；The technical process of the differential arc oxidation is carried out according to mode well known to those skilled in the art, to concrete operations flow
The application is without particularly illustrating.In this application, Ca-P-Ag coatings in order to obtain, the electricity in the micro-arc oxidation process
Solution liquid is made of following compositions：The sodium metasilicate of 40wt%, the nanometer hydroxyapatite powder of 50wt%, 5wt% sodium fluoride, >=
The glycerine of 2wt%, the sodium hydroxide of 2wt%, the nanometer Ag powder of≤1wt% and 2000mL deionized waters.The differential arc oxidation
250~400V of constant voltage；300~400Hz of pulse frequency；Duty ratio 10~15%, 20~30min of oxidization time.This Shen
Micro-arc oxidation process please be use in degradable medical synthetism stick surface recombination Ca-P-Ag coatings, so that coating is in degradable medical
Synthetism stick surface forms the coating combined closely.
In order to match the micro- of the specific requirement of different implant sites, especially stress size and Bone density and implantation
Environment, final purpose are that the healing of bone tissue and the degradation speed of magnesium alloy is made to match.Therefore, provided by the present application degradable
Synthetism stick implantation instrument further adds polynary trace alloying element in vivo on the basis of high purity magnesium and magnesium alloy has been prepared,
The bone implant material that connects that its element is formed with content is prepared when different has different mechanical property and degradation rate, to expire
The functional requirement of foot difference implant site.
For a further understanding of the present invention, with reference to embodiment to degradable synthetism stick implantation instrument provided by the invention
It is described in detail, protection scope of the present invention is not limited by the following examples.
Embodiment 1
Medical bone stick as shown in Figure 2 is provided, which is 8mm, height h by coaxially connected diameter D0For 10mm
Pedestal and diameter d be 4mm, height h1It is formed for the cylinder of 6mm, the length W of the groove in base bottom center is 6mm, height h2
For 3mm；Simultaneously the synthetism stick be magnesium alloy materials, by the Mn of Zn, 0.6wt% of Fe, 0.6wt% of 0.1wt%,
The Sr of Cu, 0.8wt% of 0.02wt% and the Mg of surplus are formed；
Ca-P-Ag coatings are grown in Medical bone stick surface in situ using micro-arc oxidation process, obtain degradable magnesium alloy
Synthetism stick implantation instrument；The electrolyte of micro-arc oxidation process specifically comprises sodium metasilicate 40wt%+ nanometer hydroxyapatite powder
Nanometer Ag powder+deionized water of last 50wt%+ sodium fluorides 5wt%+ glycerine 2wt%+ sodium hydroxides 2wt%+1wt%
2000mL, technological parameter are specially constant voltage 300V；Pulse frequency 350Hz；Duty ratio 12%, oxidization time 25min.
Degradable magnesium alloy synthetism stick implantation instrument manufactured in the present embodiment is detected, magnesium alloy synthetism stick implantation instrument is measured
Tensile strength 210MPa, nonproportional cyclic straining 140MPa, elongation 8.6%, degradation rate≤0.3mm/year.
Fig. 3 is the 3 months HE stained photographs in magnesium alloy synthetism stick implantation instrument implanted femur manufactured in the present embodiment distal end,
The effect for repairing bone tissue is as shown in the figure：Wherein purple is new bone tissue, and blue is osteogenic tissue, and white is fibr tissue.
Embodiment 2
Medical bone stick as shown in Figure 2 is provided, which is 6mm, height h by coaxially connected diameter D0For 8mm
Pedestal and diameter d be 3mm, height h1It is formed for the cylinder of 4mm, the length W of the groove in base bottom center is 4mm, height h2
For 2mm；Simultaneously the synthetism stick be magnesium alloy materials, by the Mn of Zn, 0.4wt% of Fe, 0.8wt% of 0.4wt%,
The Sr of Cu, 0.8wt% of 0.03wt% and the Mg of surplus are formed；
Ca-P-Ag coatings are grown in Medical bone stick surface in situ using micro-arc oxidation process, obtain degradable magnesium alloy
Synthetism stick implantation instrument；The electrolyte of micro-arc oxidation process specifically comprises sodium metasilicate 50wt%+ nano HA powder 40wt%+
Nanometer Ag powder+deionized water 2000mL of sodium fluoride 5wt%+ glycerine 2wt%+ sodium hydroxides 2wt%+1wt%, technological parameter
Specially constant voltage 400V；Pulse frequency 250Hz；Duty ratio 10%, oxidization time 20min.
Degradable magnesium alloy synthetism stick implantation instrument manufactured in the present embodiment is detected, magnesium alloy synthetism stick implantation instrument is measured
Tensile strength 180MPa, nonproportional cyclic straining 120MPa, elongation 10.2%, degradation rate≤0.15mm/year.
Fig. 4 is the 3 months HE stained photographs in magnesium alloy synthetism stick implantation instrument implanted femur manufactured in the present embodiment distal end,
The effect for repairing bone tissue is as shown in the figure：Wherein purple is new bone tissue, and kermesinus is osteogenic tissue, and white is fibr tissue.
Embodiment 3
Medical bone stick as shown in Figure 2 is provided, which is 4mm, height h by coaxially connected diameter D0For 6mm
Pedestal and diameter d be 4mm, height h1It is formed for the cylinder of 5mm, the length W of the groove in base bottom center is 3mm, height h2
For 2mm；Simultaneously the synthetism stick be magnesium alloy materials, by the Mn of Zn, 0.1wt% of Fe, 0.2wt% of 0.1wt%,
The Sr of Cu, 0.8wt% of 0.01wt% and the Mg of surplus are formed；
Ca-P-Ag coatings are grown in Medical bone stick surface in situ using micro-arc oxidation process, obtain degradable magnesium alloy
Synthetism stick implantation instrument；The electrolyte of micro-arc oxidation process specifically comprises sodium metasilicate 30wt%+ nanometer hydroxyapatite powder
Last 60wt%+ sodium fluorides 5wt%+ glycerine 2wt%+ sodium hydroxides 2wt%+ nanometer Ag powder 1wt%+ deionized water 2000mL,
Technological parameter is specially constant voltage 200V；Pulse frequency 200Hz；Duty ratio 12%, oxidization time 30min.
Degradable magnesium alloy synthetism stick implantation instrument manufactured in the present embodiment is detected, magnesium alloy synthetism stick implantation instrument is measured
Tensile strength 230MPa, nonproportional cyclic straining 140MPa, elongation 7.2%, degradation rate≤0.2mm/year.
Fig. 5 is the 3 months HE stained photographs in magnesium alloy synthetism stick implantation instrument implanted femur manufactured in the present embodiment distal end,
The effect for repairing bone tissue is as shown in the figure：Wherein purple is new bone tissue, and kermesinus is osteogenic tissue, and white is fibr tissue.
The explanation of above example is only intended to facilitate the understanding of the method and its core concept of the invention.It should be pointed out that pair
For those skilled in the art, without departing from the principle of the present invention, the present invention can also be carried out
Some improvements and modifications, these improvement and modification are also fallen within the protection scope of the claims of the present invention.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (10)
1. a kind of degradable synthetism stick implantation instrument, including degradable medical synthetism stick and it is compound in the degradable medical synthetism
The coating on stick surface；
The degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：It is more than 0 and small
In equal to 0.5wt% Fe, more than 0 and less than or equal to 1wt% Zn, more than 0 and less than or equal to 0.6wt% Mn, be more than 0 and
The Sr of Cu, 0.8wt% less than or equal to 0.05wt% and the Mg of surplus；
The coating is Ca-P-Ag coatings.
2. degradable synthetism stick implantation instrument according to claim 1, which is characterized in that the degradable medical synthetism stick
Including coaxially connected pedestal and cylinder, the diameter of the pedestal is more than the diameter of the cylinder, and in the bottom of the pedestal
Centre setting is fluted.
3. degradable synthetism stick implantation instrument according to claim 2, which is characterized in that the diameter of the pedestal with it is described
The ratio of the diameter of cylinder is 4:3~2:1, the ratio of the height of the height of the pedestal and the cylinder is (0.8~2):1.
4. degradable synthetism stick implantation instrument according to claim 2 or 3, which is characterized in that the diameter of the pedestal with
The ratio of the length of the groove is 1:The ratio of the height of (0.4~0.8), the height of the pedestal and the groove be (3~
8):1。
5. degradable synthetism stick implantation instrument according to claim 1, which is characterized in that in the Ca-P-Ag coatings, Ag
Content be no more than 0.1wt%, surplus be Ca and P.
6. degradable synthetism stick implantation instrument according to claim 1, which is characterized in that the quality of the Ca and the P
Than being 5:3.
7. degradable synthetism stick implantation instrument according to claim 1, which is characterized in that the thickness of the Ca-P-Ag coatings
Degree is more than 0 and is less than or equal to 0.5mm.
8. the preparation method of degradable synthetism stick implantation instrument described in claim 1, includes the following steps：
Ca-P-Ag coatings are grown in degradable medical synthetism stick surface in situ using micro-arc oxidation process；
The degradable medical synthetism stick is pure magnesium material or magnesium alloy materials, and the magnesium alloy materials include：It is more than 0 and small
In equal to 0.5wt% Fe, more than 0 and less than or equal to 1wt% Zn, more than 0 and less than or equal to 0.6wt% Mn, be more than 0 and
The Sr of Cu, 0.8wt% less than or equal to 0.05wt% and the Mg of surplus；
The coating is Ca-P-Ag coatings.
9. preparation method according to claim 8, which is characterized in that the electrolyte in the micro-arc oxidation process is by following
At being grouped as：The sodium metasilicate of 40wt%, the nanometer hydroxyapatite powder of 50wt%, the sodium fluoride of 5wt%, >=2wt% it is sweet
Oil, the sodium hydroxide of 2wt%, the nanometer Ag powder of≤1wt% and 2000mL deionized waters.
10. preparation method according to claim 8 or claim 9, which is characterized in that the constant voltage of the differential arc oxidation is 250
~400V；Pulse frequency is 300~400Hz；Duty ratio is 10~15%, 20~30min of oxidization time.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331426A (en) * | 2019-07-02 | 2019-10-15 | 山东农业工程学院 | Magnesium alloy argentiferous micro-arc oxidation electrolyte, bioceramic film layer and preparation method |
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| CN101629260A (en) * | 2008-07-18 | 2010-01-20 | 中国科学院金属研究所 | Medical absorbable Mg-Zn-Mn-Ca magnesium alloy |
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Address after: 523000 Dongguan Yi'an Technology Co., Ltd., Yinquan Industrial Zone, Qingxi Town, Dongguan City, Guangdong Province Patentee after: DONGGUAN EONTEC Co.,Ltd. Patentee after: Dongguan magnesium Medical Equipment Co.,Ltd. Address before: 523000 Dongguan Yi'an Technology Co., Ltd., Yinquan Industrial Zone, Qingxi Town, Dongguan City, Guangdong Province Patentee before: DONGGUAN EONTEC Co.,Ltd. Patentee before: DONGGUAN MEIAN MAGNESIUM TECHNOLOGY Co.,Ltd. |
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