CN108744031A - A kind of calcium phosphate bone cement and preparation method thereof by temperature regulation and control degradation - Google Patents
A kind of calcium phosphate bone cement and preparation method thereof by temperature regulation and control degradation Download PDFInfo
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- CN108744031A CN108744031A CN201810812437.3A CN201810812437A CN108744031A CN 108744031 A CN108744031 A CN 108744031A CN 201810812437 A CN201810812437 A CN 201810812437A CN 108744031 A CN108744031 A CN 108744031A
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- sodium percarbonate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The invention discloses a kind of calcium phosphate bone cements by temperature regulation and control degradation, and it includes the calcium phosphate bone cement liquid phase agent being used cooperatively and solid phase pulvis to prepare raw material；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；The solid phase pulvis is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis；It is SODIUM PERCARBONATE-wax microsphere compound that surface coats gelatin layer that the responsive to temperature type oxygen, which generates compound, and SODIUM PERCARBONATE-wax microsphere compound is the SODIUM PERCARBONATE microsphere compound that surface coats wax layer.The invention also discloses the preparation method of the above-mentioned calcium phosphate bone cement by temperature regulation and control degradation, calcium phosphate bone cement prepared by the present invention can accelerate its degradation rate by heat treatment, and safety is good, is suitable for mass production.
Description
Technical field
The invention belongs to biomedical material technologies, and in particular to a kind of calcium phosphate bone water by temperature regulation and control degradation
Mud and preparation method thereof.
Background technology
Calcium phosphate bone cement be it is a kind of can not only help human body hard tissue reparation with rebuild, but also can be used as drug release carry
The biomedical material of body is widely used in fixed, gear division reparation etc. of cohering of bone defect, fracture and joint prosthesis.Phosphorus
Sour calcium bone cement has many advantages, such as that preparation is easy, and random-shaping, compared with other bone cements, its biocompatibility is more preferable,
Cure not heat production in crystallization process, safety higher.But the internal degradation rate of existing calcium phosphate bone cement is slower, one
Determine to hinder the regeneration and reconstruction of body bone tissue in degree, it is even more impossible to realize the controllable drop to calcium phosphate bone cement in vitro
Solution.Currently, can be had not been reported in vitro by the method and product of heat effect change calcium phosphate bone cement degradation rate.
Invention content
In order to solve the above problem of the existing technology, present invention aims at provide it is a kind of by temperature regulation and control degradation
Calcium phosphate bone cement and preparation method thereof.
The technical solution adopted in the present invention is：A kind of calcium phosphate bone cement by temperature regulation and control degradation prepares raw material
Include with the use of liquid phase agent and solid phase pulvis；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；The solid phase powder
Agent is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis, wherein solid phase pulvis
The mass fraction that middle responsive to temperature type oxygen generates compound is 1%-20%；The common calcium phosphate bone cement is phosphoric acid hydrogen
Calcium-type alpha tricalcium phosphate-calcium carbonate system bone cement, tetracalcium phosphate-type alpha tricalcium phosphate system bone cement, tetracalcium phosphate-β-
In tricalcium phosphate-calcium dihydrogen phosphate system bone cement or calcium dihydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement
Any one；It is compound that the responsive to temperature type oxygen generates SODIUM PERCARBONATE-wax microballoon that compound is surface cladding gelatin layer
Object, wherein the mass fraction that responsive to temperature type oxygen generates gelatin in compound is 15%-75%, and SODIUM PERCARBONATE-wax microballoon is multiple
It is the SODIUM PERCARBONATE microsphere compound that surface coats wax layer to close object, the quality of SODIUM PERCARBONATE in SODIUM PERCARBONATE-wax microsphere compound
Score is 30%-90%.
Optionally, a diameter of 10 microns -1 millimeter of the SODIUM PERCARBONATE-wax microsphere compound.
Optionally, the wax includes candelila wax, palm wax, rice bran wax, beeswax, insect wax, lanocerin, spermaceti, lignite
In wax, paraffin, microwax, pertroleum wax, polyethylene wax, polypropylene wax, one vinyl acetate of ethylene copolymerization wax, oxidized polyethylene wax
It is at least one.
The invention also discloses a kind of preparation methods of the calcium phosphate bone cement by temperature regulation and control degradation, including following step
Suddenly：
A, SODIUM PERCARBONATE powder is added in the wax of melting, is stirred and evenly mixed, it is with Microsphere manufacture machine that SODIUM PERCARBONATE-wax is compound
Object, which makes, becomes SODIUM PERCARBONATE-wax microsphere compound, is stood under low temperature until wax thoroughly solidifies；
B, SODIUM PERCARBONATE-wax microsphere compound is embathed with deionized water, removes the SODIUM PERCARBONATE of its remained on surface, dries；
C, the SODIUM PERCARBONATE-wax microsphere compound dried is wrapped up with gelatin solution, is stood under low temperature up to gelatin solidification,
Compound is generated up to responsive to temperature type oxygen；
D, responsive to temperature type oxygen generation compound is mixed with common calcium phosphate bone cement solid phase pulvis, obtains solid phase powder
Agent：By the calcium phosphate bone cement solid-phase complex of temperature regulation and control degradation；
E, solid phase pulvis is mixed with common calcium phosphate bone cement liquid phase agent and reconcile uniformly, wait for thoroughly solidify to get by
The calcium phosphate bone cement of temperature regulation and control degradation.
Optionally, the solubility of gelatin is 8%-50% in gelatin solution described in step C.
Optionally, the wax melted described in step A includes candelila wax, palm wax, rice bran wax, beeswax, insect wax, wool
Wax, spermaceti, lignite wax, paraffin, microwax, pertroleum wax, polyethylene wax, polypropylene wax, one vinyl acetate of ethylene copolymerization wax and
At least one of oxidized polyethylene wax.
Optionally, in step A, a diameter of 10 microns -1 millimeter of the SODIUM PERCARBONATE-wax microsphere compound.
Optionally, in step B, the mass fraction for drying SODIUM PERCARBONATE in rear SODIUM PERCARBONATE-wax microsphere compound is 30%-
90%.
Optionally, in step C, the mass fraction that the responsive to temperature type oxygen generates gelatin in compound is 15%-
75%.
Optionally, in step D, the mass fraction that responsive to temperature type oxygen generates compound in the solid phase pulvis is 1%-
20%.
Optionally, in step D and E, the common calcium phosphate bone cement is calcium monohydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate
System bone cement, tetracalcium phosphate-type alpha tricalcium phosphate system bone cement, tetracalcium phosphate-bata-tricalcium phosphate-calcium dihydrogen phosphate system
Any one united in bone cement or calcium dihydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement.
Beneficial effects of the present invention are：
(1) at the initial stage of bone tissue reparation, calcium phosphate bone cement plays the functions such as load-bearing and drug release, and works as bone group
Reparation is knitted when proceeding to certain stage, the characteristic that calcium phosphate bone cement is difficult to degrade hinder bone tissue reparation further into
Row；The present invention keeps stable at a lower temperature, when temperature rise to oxygen generates the melting temperature of compound, you can promote
The reaction that oxygen generates is sent out, calcium phosphate bone cement is made to form internal pressure；When internal pressure is larger, gas will destroy the knot of calcium phosphate bone cement
Structure simultaneously forms hole, to accelerate the degradation of calcium phosphate bone cement.
(2) each constituents nontoxicity, the teratogenesis in the present invention, safe, production is easy, is suitble to mass production；It crosses
Sodium carbonate is reacted with water generates oxygen and sodium carbonate, and oxygen and sodium carbonate are non-toxic, nonirritant, securely and reliably.
(3) wax that can select different melting temperatures in the present invention according to different application requirements changes oxygen generation
To change controllable degradation calcium phosphate bone cement the triggering temperature that degradation accelerates occurs for the melting temperature of compound.
(4) preparation method of the invention is easy, raw materials used simple, is suitable for mass production, and safety is good, meets clinic
The requirement of application.
Description of the drawings
Fig. 1 is that the weight by the calcium phosphate bone cement of temperature regulation and control degradation in degradation process prepared in embodiment 4 is damaged
Lose change curve.
Fig. 2 is the pressure resistance by the calcium phosphate bone cement of temperature regulation and control degradation in degradation process prepared in embodiment 4
Spend change curve.
Specific implementation mode
Below in conjunction with the accompanying drawings and specific embodiment the present invention is further elaborated.
Embodiment 1
A kind of calcium phosphate bone cement by temperature regulation and control degradation, it includes the liquid phase agent being used cooperatively and solid phase to prepare raw material
Pulvis；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；Institute
It is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis to state solid phase pulvis, wherein
The mass fraction that responsive to temperature type oxygen generates compound in solid phase pulvis is 5%；The common calcium phosphate bone cement is phosphoric acid
Hydrogen calcium-type alpha tricalcium phosphate-calcium carbonate system bone cement；It is that surface coats gelatin that the responsive to temperature type oxygen, which generates compound,
SODIUM PERCARBONATE-wax microsphere compound of layer, wherein the mass fraction of gelatin is in responsive to temperature type oxygen generation compound
35%, SODIUM PERCARBONATE-wax microsphere compound is the SODIUM PERCARBONATE microsphere compound that surface coats wax layer, and SODIUM PERCARBONATE accounts for percarbonic acid
The mass fraction of sodium-wax microsphere compound is 80%.A diameter of 200 microns of the SODIUM PERCARBONATE-wax microsphere compound.It is described
Wax uses paraffin.
Embodiment 2
A kind of calcium phosphate bone cement by temperature regulation and control degradation, it includes the liquid phase agent being used cooperatively and solid phase to prepare raw material
Pulvis；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；Institute
It is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis to state solid phase pulvis, wherein
The mass fraction that responsive to temperature type oxygen generates compound in solid phase pulvis is 1%；The common calcium phosphate bone cement is phosphoric acid
Four calcium-type alpha tricalcium phosphate system bone cement；The responsive to temperature type oxygen generates compound and crosses carbon for surface cladding gelatin layer
Sour sodium-wax microsphere compound, wherein the mass fraction that responsive to temperature type oxygen generates gelatin in compound is 15%, percarbonic acid
Sodium-wax microsphere compound is the SODIUM PERCARBONATE microsphere compound that surface coats wax layer, and it is multiple that SODIUM PERCARBONATE accounts for SODIUM PERCARBONATE-wax microballoon
The mass fraction for closing object is 30%.A diameter of 10 microns of the SODIUM PERCARBONATE-wax microsphere compound.The wax uses crystallite
Wax, pertroleum wax and polyethylene wax.
Embodiment 3
A kind of calcium phosphate bone cement by temperature regulation and control degradation, it includes the liquid phase agent being used cooperatively and solid phase to prepare raw material
Pulvis；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；The liquid phase agent is common calcium phosphate bone cement liquid phase agent；Institute
It is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis to state solid phase pulvis, wherein
The mass fraction that responsive to temperature type oxygen generates compound in solid phase pulvis is 20%；The common calcium phosphate bone cement is phosphoric acid
Four calcium-bata-tricalcium phosphate-calcium dihydrogen phosphate system bone cement；The responsive to temperature type oxygen generates compound and is coated for surface
The SODIUM PERCARBONATE of gelatin layer-wax microsphere compound, wherein the mass fraction of gelatin is in responsive to temperature type oxygen generation compound
75%, SODIUM PERCARBONATE-wax microsphere compound is the SODIUM PERCARBONATE microsphere compound that surface coats wax layer, and SODIUM PERCARBONATE accounts for percarbonic acid
The mass fraction of sodium-wax microsphere compound is 90%.A diameter of 1 millimeter of the SODIUM PERCARBONATE-wax microsphere compound.The wax
Using polypropylene wax, one vinyl acetate of ethylene copolymerization wax and oxidized polyethylene wax.
Embodiment 4
In the present embodiment, by the calcium phosphate bone cement that the raw material proportioning preparation of embodiment 1 is degraded by temperature regulation and control, including with
Lower step：
A, SODIUM PERCARBONATE powder is added in the paraffin of melting, is stirred and evenly mixed, with Microsphere manufacture machine by SODIUM PERCARBONATE-paraffin
Compound makes SODIUM PERCARBONATE-paraffin microsphere compound as 200 micron grain sizes, is stood under low temperature until paraffin thoroughly coagulates
Gu；
B, SODIUM PERCARBONATE-paraffin microsphere compound is embathed with deionized water, removes the SODIUM PERCARBONATE of its remained on surface, dries in the air
Dry, the mass fraction for drying SODIUM PERCARBONATE in rear sodium carbonate-paraffin microsphere compound is 80%；
C, the gelatin solution for being 20% with solubility wraps up SODIUM PERCARBONATE-paraffin microsphere compound for having dried, quiet under low temperature
It sets until gelatin solidifies generates compound to get responsive to temperature type oxygen, the mass fraction of gelatin is 35% in coagulum；
D, responsive to temperature type oxygen is generated into compound and calcium monohydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement
Solid phase pulvis mixes, and obtains solid phase pulvis：By the calcium phosphate bone cement solid-phase complex of temperature regulation and control degradation, wherein solid phase powder
The mass fraction that responsive to temperature type oxygen generates compound in agent is 5%；
E, solid phase pulvis is mixed and is reconciled with calcium monohydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement liquid phase agent
Uniformly, it waits for thoroughly solidifying to get by the calcium phosphate bone cement of temperature regulation and control degradation.SODIUM PERCARBONATE is hydrogen peroxide and sodium carbonate
Additive compound, being in direct contact with water can irreversible generation oxygen and sodium carbonate.Wax in the present embodiment is as hydrophobic material
Material makes SODIUM PERCARBONATE stablize isolation with water, and only when the melting temperature of temperature rise to wax, SODIUM PERCARBONATE could be contacted with water
And oxygen is quickly generated, internal pressure is generated, and then destroy the structure of calcium phosphate bone cement, achievees the purpose that accelerate its degradation.
The calcium phosphate bone cement by temperature regulation and control degradation that the present embodiment is prepared, to its degradation rate and compression strength
It is tested, testing result is as follows：
The 0.05M Tris-HCl solution for preparing PH 7.4 first is tested for external degradation.Sample to be tested is divided to two groups：It is real
Test group and control group.Experimental group sample to be tested pre-processed under melting temperature, and control group is not processed.Experimental group and control group
Sample to be tested is dipped under 37 degrees celsius equipped in 0.05M Tris-HCl solution centrifuge tubes.Degraded solutions with it is to be measured
The mass ratio of sample is 20：1.In the first week in detection process, a degraded solutions are replaced within every 24 hours, from second
Start in a week to replace a degraded solutions in each week.Sample to be tested was degraded respectively after 1,2,3,4 week, was taken out 37
It is dried 2-3 days under degree Celsius, then dries 3-4 days at 60 c until example weight maintains to stablize.
As shown in Figure 1, being to be changed song by weight loss of the calcium phosphate bone cement that temperature regulation and control are degraded in degradation process
Line, it can be seen that the percent weight loss of experimental group is 4 times of control group or so, with the propulsion of degradation time, the number
Value is also gradually increasing, and why will appear this difference, is because experimental group has carried out Grape berry, the temperature of processing is stone
The melting temperature of wax, thus after Grape berry, paraffin is melted, part SODIUM PERCARBONATE exposes, exposed percarbonic acid
Sodium is reacted with water, generates oxygen, generates internal pressure, and then destroy the structure of calcium phosphate bone cement, achievees the purpose that accelerate its degradation；
And control group is without Overheating Treatment, thus paraffin does not melt, is only normally degraded, it can not accelerated degradation.
Wherein, the calculation formula of percent weight loss is as follows：
Weight loss (%)=(Mo-Md)/Mo* 100%
MoRefer to the original weight of calcium phosphate bone cement；MdRefer to the remaining weight after calcium phosphate bone cement is degraded.
As shown in Fig. 2, being to be changed song by compression strength of the calcium phosphate bone cement that temperature regulation and control are degraded in degradation process
Line, it can be seen that the compression strength of experimental group is lower than the compression strength of control group always, this is because the degradation speed of experimental group
Rate is higher than the degradation rate of control group.In Fig. 1, n=3 indicates 3 groups of experimental group, 3 groups of control group, by the survey of 3 groups of experimental groups in figure
Examination value is averaged, the test value of 3 groups of control groups takes average drafting curve.In Fig. 2, n=3 indicates same meaning.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is every to fall into the claims in the present invention confining spectrum
Technical solution, be within the scope of the present invention.
Claims (10)
1. a kind of calcium phosphate bone cement by temperature regulation and control degradation, it is characterised in that：
It includes the liquid phase agent being used cooperatively and solid phase pulvis that it, which prepares raw material,；
The liquid phase agent is common calcium phosphate bone cement liquid phase agent；
The solid phase pulvis is the mixture that responsive to temperature type oxygen generates compound and common calcium phosphate bone cement solid phase pulvis,
Wherein, the mass fraction that responsive to temperature type oxygen generates compound in solid phase pulvis is 1%-20%；
The common calcium phosphate bone cement is calcium monohydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement, tetracalcium phosphate-α-
Tricalcium phosphate system bone cement, tetracalcium phosphate-bata-tricalcium phosphate-calcium dihydrogen phosphate system bone cement or calcium dihydrogen phosphate-
Any one in type alpha tricalcium phosphate-calcium carbonate system bone cement；
It is SODIUM PERCARBONATE-wax microsphere compound that surface coats gelatin layer that the responsive to temperature type oxygen, which generates compound, wherein
The mass fraction that responsive to temperature type oxygen generates gelatin in compound is 15%-75%, and SODIUM PERCARBONATE-wax microsphere compound is table
The SODIUM PERCARBONATE microsphere compound of bread propolizing layer, the mass fraction of SODIUM PERCARBONATE is in SODIUM PERCARBONATE-wax microsphere compound
30%-90%.
2. the calcium phosphate bone cement according to claim 1 by temperature regulation and control degradation, it is characterised in that：The percarbonic acid
A diameter of 10 microns -1 millimeter of sodium-wax microsphere compound.
3. the calcium phosphate bone cement according to claim 1 by temperature regulation and control degradation, it is characterised in that：The wax includes small
Candle vegetable wax, palm wax, rice bran wax, beeswax, insect wax, lanocerin, spermaceti, lignite wax, paraffin, microwax, pertroleum wax, polyethylene
At least one of wax, polypropylene wax, one vinyl acetate of ethylene copolymerization wax, oxidized polyethylene wax.
4. a kind of preparation method of calcium phosphate bone cement by temperature regulation and control degradation, which is characterized in that include the following steps：
A, SODIUM PERCARBONATE powder is added in the wax of melting, is stirred and evenly mixed, with Microsphere manufacture machine by SODIUM PERCARBONATE-wax compound system
It is made for SODIUM PERCARBONATE-wax microsphere compound, is stood under low temperature until wax thoroughly solidifies；
B, SODIUM PERCARBONATE-wax microsphere compound is embathed with deionized water, removes the SODIUM PERCARBONATE of its remained on surface, dries；
C, wrap up SODIUM PERCARBONATE-wax microsphere compound for having dried with gelatin solution, stood under low temperature until gelatin solidify to get
Responsive to temperature type oxygen generates compound；
D, responsive to temperature type oxygen generation compound is mixed with common calcium phosphate bone cement solid phase pulvis, obtains solid phase pulvis：
By the calcium phosphate bone cement solid-phase complex of temperature regulation and control degradation；
E, solid phase pulvis is mixed with common calcium phosphate bone cement liquid phase agent and is reconciled uniformly, wait for thoroughly solidifying to get by temperature
Regulate and control the calcium phosphate bone cement of degradation.
5. the preparation method of the calcium phosphate bone cement according to claim 4 by temperature regulation and control degradation, it is characterised in that：Step
The wax melted described in rapid A includes candelila wax, palm wax, rice bran wax, beeswax, insect wax, lanocerin, spermaceti, lignite wax, stone
In wax, microwax, pertroleum wax, polyethylene wax, polypropylene wax, one vinyl acetate of ethylene copolymerization wax and oxidized polyethylene wax extremely
Few one kind.
6. the preparation method of the calcium phosphate bone cement according to claim 4 by temperature regulation and control degradation, it is characterised in that：Step
In rapid A, a diameter of 10 microns -1 millimeter of the SODIUM PERCARBONATE-wax microsphere compound.
7. the preparation method of the calcium phosphate bone cement by temperature regulation and control degradation according to claim 4 or 6, feature exist
In：In step B, the mass fraction for drying SODIUM PERCARBONATE in rear SODIUM PERCARBONATE-wax microsphere compound is 30%-90%.
8. the preparation method of the calcium phosphate bone cement according to claim 4 by temperature regulation and control degradation, it is characterised in that：Step
In rapid C, the solubility of gelatin is 8%-50% in institute's gelatine solution, and the responsive to temperature type oxygen generates gelatin in compound
Mass fraction is 15%-75%.
9. the preparation method of the calcium phosphate bone cement according to claim 4 by temperature regulation and control degradation, it is characterised in that：Step
In rapid D, the mass fraction that responsive to temperature type oxygen generates compound in the solid phase pulvis is 1%-20%.
10. the preparation method of the calcium phosphate bone cement according to claim 4 by temperature regulation and control degradation, it is characterised in that：
The common calcium phosphate bone cement is calcium monohydrogen phosphate-type alpha tricalcium phosphate-calcium carbonate system bone cement, tetracalcium phosphate-alpha-phosphate
Tricalcium system bone cement, tetracalcium phosphate-bata-tricalcium phosphate-calcium dihydrogen phosphate system bone cement or calcium dihydrogen phosphate-α-phosphorus
Any one in sour tricalcium-calcium carbonate system bone cement.
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| CN109529043A (en) * | 2018-11-26 | 2019-03-29 | 吴容思 | A kind of solidliquid mixture and preparation method thereof that polyvinyl alcohol hydrogel can be frozen into real time under temperature control |
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