CN108743954A - Improve the method for dispersivity of grease-contained traditional Chinese medicinal granules in water - Google Patents
Improve the method for dispersivity of grease-contained traditional Chinese medicinal granules in water Download PDFInfo
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- CN108743954A CN108743954A CN201810663575.XA CN201810663575A CN108743954A CN 108743954 A CN108743954 A CN 108743954A CN 201810663575 A CN201810663575 A CN 201810663575A CN 108743954 A CN108743954 A CN 108743954A
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- water
- chinese medicinal
- traditional chinese
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
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Abstract
The present invention relates to a kind of methods improving dispersivity of grease-contained traditional Chinese medicinal granules in water, the method is in the concentrate after the water of Chinese medicine containing grease type extracts and concentrates, the surfactant for being equivalent to concentration 0.1~8% weight percent of fluid solid content is added, stirring and dissolving, after mixing, traditional Chinese medicinal extract powder is prepared into using drying process with atomizing, then through Chinese medicinal granule is made；The HLB value of the surfactant is 7~11, including hydroxylating phosphatide, polysorbate, sucrose fatty ester.The present invention makes pellet has good dispersibility in water.The present invention is easy to operate, it is easy to accomplish industrial production can be used to improve dispersibility when Chinese medicinal granule containing grease type adds water to rush molten, improve the compliance of patient and the accuracy of taking dose, ensure clinical efficacy.The present invention can also improve the bulk density of traditional Chinese medicinal extract powder, convenient for being smoothed out for the processes such as subsequently pelletize, pack.
Description
The present invention relates to a kind of methods improving dispersivity of grease-contained traditional Chinese medicinal granules in water.Belong to Chinese medicinal granule
Preparation technique field.
Chinese medicinal granule is under guidance of traditional Chinese medicine theory, using the prepared slices of Chinese crude drugs of specification Preparation process as raw material, to use
Regulation and standardization single medicinal material made of the modern pharmaceuticals technologies such as science extraction, low temperature concentration, wink-dry and granulating process
Granule.
The manufactured Chinese medicine leaching after water extraction, concentration and drying containing the more Chinese medicine of lubricant component (fruit and seed class etc.)
Cream powder hydrophobicity is stronger, therefore when Jia Shuichong is molten, easily ties lumped, floats on the water surface or be adhered to wall, influences patient
The compliance of medication and the accuracy of medication dose, and then influence clinical efficacy.Chinese medicinal granule field, which lacks, at present improves
Dispersed research in the veriety water.
The purpose of the present invention is to overcome the above shortcomings and to provide a kind of can improve in the water of Chinese medicinal granule containing grease type to divide
Dissipate the method for property.
The purpose of the present invention is be achieved by the following measures：Disperse in a kind of improvement water of Chinese medicinal granule containing grease type
Property method, the method be the water of Chinese medicine containing grease type extract and concentrate after concentrate in, addition be equivalent to concentrate
The surfactant of 0.1~8% weight percent of solid content, stirring and dissolving are prepared using drying process with atomizing after mixing
At traditional Chinese medicinal extract powder, then through Chinese medicinal granule is made.
Hydrophile-lipophile balance (HLB) value of the surfactant be 7~11, including hydroxylating phosphatide, polysorbate or
Sucrose fatty ester, wherein it is preferred that hydroxylating phosphatide.
If surfactant is solid powder, Adding Way is：Water solubility that is first and contributing to surfactant-dispersed
It after auxiliary material is mixed well by 1: 1~20 weight ratio, is added while stirring, is conducive to solid surfactant powder in liquid
It is uniformly dissolved.
The water soluble adjuvant is maltodextrin, lactose, sucrose, mannitol or glucose.
Present invention design has certain physical pharmaceutics foundation, i.e., is 7~11 surface-actives present invention utilizes HLB value
The mechanism of action of wetting function possessed by agent, the wetting agent is：After medicinal material extracting in water, concentration containing grease-like composition
Solution is an oil mixing with water system, and grease composition is dispersed in water with small oil droplet, forms oil water two phase system, and wetting agent is added
Afterwards, oil-water interfaces are attracted to, it is regular to align into film or electric double layer, on the one hand, these are adsorbed on oil droplet table
Towards internal oil phase, water-wet side makes drop towards outer water phase, then by drying process with atomizing at the surfactant hydrophobic end in face
Wink-dry, finally so that made extract powder has dispersibility in good water；On the other hand, oil phase and the table of water phase can be reduced
Face tension and surface free energy prevent the merging of oil droplet, and size droplet diameter smaller, gained pile of grounds density improves after spray drying,
The processing of the postorders such as the packaging convenient for extract powder.
The surfactant that above-mentioned HLB value is 7~11 has amphoteric ion type, nonionic and anionic, wherein both sexes
Ionic surface active agent toxicity is minimum, is secondly nonionic surface active agent, and therefore, the present invention selects the lower both sexes of toxicity
Ionic surfactant hydroxylating phosphatide and nonionic surface active agent polysorbate, sucrose fatty ester.Consider
The wetting function and toxicity size of surfactant, preferably amphoteric ionic surfactant hydroxylating phosphatide.
The beneficial effects of the invention are as follows：
(1) it uses surfactant modified to containing grease type traditional Chinese medicinal extract powder progress surface, improves containing in grease type
It is dispersed in the surface wettability and water of medicine composition particle, improve the accurate of compliance that patient clinical uses and taking dose
Property, it ensure that clinical efficacy；
(2) since surfactant reduces the interfacial free energy and surface tension at water phase and oil phase interface so that drop
Powder diameter smaller that is more tiny, being spray-dried, heap density higher, therefore be more convenient for packing.
Embodiment 1：
100kg seed of Oriental arborvitae water is taken to extract concentrate, previously prepared hydroxylating phosphatide and malt paste is added in solid content 9kg
Smart mixture (weight ratio 1: 1) 0.018kg, stirs while adding, until being completely dissolved, then on centrifugal spray dryer
It is spray-dried, obtained powder can disperse rapidly in water, no conglomeration indissoluble phenomenon.
Embodiment 2：
100kg fructus cannabis water is taken to extract concentrate, previously prepared hydroxylating phosphatide and lactose is added in solid content 20kg
(or sucrose, mannitol or glucose) mixture (weight ratio 1: 5) 0.96kg, stirs while adding, until being completely dissolved, then
It is spray-dried on centrifugal spray dryer, obtained powder can disperse rapidly in water, no conglomeration indissoluble phenomenon.
Embodiment 3：
100kg Radix Glehniae water is taken to extract concentrate, solid content 25kg is added polysorbate 1kg, stirs evenly, then exist
It is spray-dried on centrifugal spray dryer, obtained powder can disperse rapidly in water, no conglomeration indissoluble phenomenon.
Embodiment 4：
100kg brush-cherry seed water is taken to extract concentrate, sucrose fatty ester 0.96kg is added in solid content 12kg, when being added
Then stirring is spray-dried, gained powder can divide rapidly in water until being completely dissolved on centrifugal spray dryer
It dissipates, no conglomeration indissoluble phenomenon.
Embodiment 5：
100kg peach kernel water is taken to extract concentrate, solid content about 15kg is added polysorbate 0.15kg, stirs while adding,
Then it is spray-dried on centrifugal spray dryer, gained powder can disperse rapidly in water, no conglomeration indissoluble phenomenon.
The surfactant can also use Arabic gum, gelatin, tragacanth, polyoxyethylene fatty acid ester or polyoxy
Ethylene aliphatic alcohol ester etc..
Claims (2)
1. a kind of method improving dispersivity of grease-contained traditional Chinese medicinal granules in water, it is characterised in that the method is in oil-containing
In concentrate after the extraction of lipid Chinese medicine water and concentration, it is added and is equivalent to concentration 0.1~8% weight percent of fluid solid content
Surfactant, stirring and dissolving are prepared into traditional Chinese medicinal extract powder, then through being made using drying process with atomizing after mixing
Chinese medicinal granule；
The surfactant is selected from the hydroxylating phosphatide, polysorbate, sucrose-fatty that hydrophilic lipophilic balance is 7~11
Ester, Arabic gum, gelatin, polyoxyethylene fatty acid ester or polyoxyethylene fatty alcohol ester.
2. a kind of method improving dispersivity of grease-contained traditional Chinese medicinal granules in water according to claim 1, feature
It is：If the surfactant is solid powder, Adding Way is：First 1: 1~20 weight ratio are pressed with water soluble adjuvant
After mixing well, it is added while stirring；The water soluble adjuvant is that maltodextrin, lactose, sucrose, mannitol or glucose are water-soluble
Property auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810663575.XA CN108743954A (en) | 2018-06-25 | 2018-06-25 | Improve the method for dispersivity of grease-contained traditional Chinese medicinal granules in water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810663575.XA CN108743954A (en) | 2018-06-25 | 2018-06-25 | Improve the method for dispersivity of grease-contained traditional Chinese medicinal granules in water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108743954A true CN108743954A (en) | 2018-11-06 |
Family
ID=63977070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810663575.XA Withdrawn CN108743954A (en) | 2018-06-25 | 2018-06-25 | Improve the method for dispersivity of grease-contained traditional Chinese medicinal granules in water |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108743954A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492396A (en) * | 2023-04-03 | 2023-07-28 | 神威药业集团有限公司 | Preparation method of bunge cherry seed formula particles |
-
2018
- 2018-06-25 CN CN201810663575.XA patent/CN108743954A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492396A (en) * | 2023-04-03 | 2023-07-28 | 神威药业集团有限公司 | Preparation method of bunge cherry seed formula particles |
| CN116492396B (en) * | 2023-04-03 | 2024-03-26 | 神威药业集团有限公司 | Preparation method of bunge cherry seed formula particles |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181106 |
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| WW01 | Invention patent application withdrawn after publication |