CN108742945A - A kind of minimally invasive elevator belt of face, its moulding process and its working method - Google Patents

A kind of minimally invasive elevator belt of face, its moulding process and its working method Download PDF

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Publication number
CN108742945A
CN108742945A CN201810448698.1A CN201810448698A CN108742945A CN 108742945 A CN108742945 A CN 108742945A CN 201810448698 A CN201810448698 A CN 201810448698A CN 108742945 A CN108742945 A CN 108742945A
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CN
China
Prior art keywords
face
minimally invasive
elevator belt
protrusion
poly
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Application number
CN201810448698.1A
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Chinese (zh)
Inventor
张文芳
苑兵
苑一兵
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Circle Holds Biological Medicine Wuxi Co Ltd
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Circle Holds Biological Medicine Wuxi Co Ltd
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Priority to CN201810448698.1A priority Critical patent/CN108742945A/en
Publication of CN108742945A publication Critical patent/CN108742945A/en
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059Cosmetic or alloplastic implants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D7/00Producing flat articles, e.g. films or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)

Abstract

A kind of minimally invasive elevator belt of face of present invention offer, its moulding process and its working method, the minimally invasive elevator belt of face includes the elongated straps body for having thickness, multiple connecting holes are distributed on the one side with body, multiple protrusions for being pierced into facial fascia superficialis system are distributed on another side.The present invention provides a kind of minimally invasive elevator belts of face simple in structure, easy to use, good fixing effect, and compared with prior art, the present invention solves and stays the end of a thread and fixed unstable clinical problem after current hangnail line suspends in midair.

Description

A kind of minimally invasive elevator belt of face, its moulding process and its working method
Technical field
The present invention relates to a kind of plastic operation materials, and in particular to a kind of minimally invasive elevator belt of face, its moulding process and its Working method.
Background technology
With advancing age, face appearance relaxes, is sagging, and specific manifestation goes out tissue recess, tissue moves down accumulation, elasticity The clinical symptoms such as reduction, wrinkle increase.It is a kind of common medical hand in beautifying face plastic operation that face crinkle-removing, which promotes operation, Then art arrive nonabsorable material from traditional Tossed Mung Clear Noodles in Sauce operation to the promotion art of mini-invasive incision, then arrive PDO, PPDO, PLLA etc. can be a quantum leap of medical cosmetology technology by the material implantation that body tissue is metabolized, and it is small, extensive that technology possesses wound It answers advantages, the clinics such as fast, effect duration is long, can be implanted into repeatedly and is able to extensive utilization.But mini-invasive incision, which promotes art, is Various suspention lines are implanted between facial skin and muscle by minimally invasive method, to the relative position of facial muscles and skin It is adjusted, to achieve the purpose that wrinkle removal beauty treatment, although wound is small, the guiding needle due to burying suspention line at present is straight Needle, therefore the suspention line being embedded between skin and muscle is also linearly to be distributed, so the position of suspention is single point, is drawn Position be also local, cannot achieve the purpose that integrally to improve, overall effect unobvious.
For this purpose, clinic is highly desirable to a kind of better implantation instrument of minimally invasive fixed effect and method.
Invention content
The technical problem to be solved in the present invention is to provide a kind of minimally invasive elevator belt of face, its moulding process and its work sides Method, simple in structure, easy to use, good fixing effect solve to stay the end of a thread and fixation insecure after current hangnail line suspention Clinical problem.
In order to solve the above technical problems, the embodiment of the present invention provides a kind of minimally invasive elevator belt of face, including has thickness Multiple connecting holes are distributed on the one side with body in elongated straps body, and it is shallow that multiple piercings faces are distributed on another side The protrusion of fascia system.
Wherein, the connecting hole is through the through-hole with body.
Further, the structure snd size of each protrusion with side side are identical, and it is described protrusion have can be inserted into through-hole And with the structure snd size of through-hole close-fitting.
The structure snd size of the protrusion with side side can also be different, multiple protrusions point with side side described at this time For the first bonding pad protrusion and the first lifting zone protrusion, first bonding pad protrusion have can be inserted into through-hole and with through-hole close-fitting Structure snd size.
Wherein, the connecting hole with one side of body is blind hole.
If the blind hole overlaps in the axial direction with the protrusion with another side of body, at this point, if the depth of the blind hole More than the thickness with body, the structure snd size of the protrusion with side side cannot be all identical, then described with side side Protrusion be divided into the second bonding pad protrusion and the second lifting zone protrusion, second bonding pad protrusion have can be inserted into blind hole and with it is blind The structure snd size of hole close-fitting.If the depth of the blind hole is less than the thickness with body, the structure of the protrusion with side side Also cannot be all identical with size, the protrusion with side side is divided into third bonding pad protrusion and third lifting zone protrusion, Third bonding pad protrusion have can be inserted into blind hole and with the structure snd size of blind hole close-fitting.
If the blind hole and the protrusion with another side of body are misaligned in the axial direction.At this point, if the depth of the blind hole Degree is more than the thickness with body, and the structure snd size of each protrusion with side side can be identical, and the protrusion has and can insert Enter blind hole and with the structure snd size of blind hole close-fitting.The structure snd size of each protrusion with side side can not also all phases Together, the protrusion with side side described at this time is divided into the 4th bonding pad protrusion and the 4th lifting zone protrusion, and the 4th bonding pad is convex Rise have can be inserted into blind hole and with the structure snd size of blind hole close-fitting.
If the depth of the blind hole is less than the thickness with body, the structure snd size of each protrusion with side side cannot All identical, the protrusion with side side described at this time is divided into the 5th bonding pad protrusion and the 5th lifting zone protrusion, the 5th connection Area's protrusion have can be inserted into blind hole and with the structure snd size of blind hole close-fitting.
Wherein, the lower end outside of the protrusion is equipped with hangnail.
Wherein, the width with body is 0.01mm-100mm, thickness 0.01mm-10mm.
Preferably, the width with body is 0. 1mm-10mm, thickness 0.05mm-3mm.
Wherein, the material for preparing with body is degradable biomaterial.
Preferably, the degradable biomaterial includes the high molecular material of biological source and abiotic source, wherein
The high molecular material of the biological source includes:Collagen and its derivative, cellulose and its derivates, chitosan and its derivative Object, hyaluronic acid and its derivative;
The high molecular material in the abiotic source includes:Polylactic acid, polycaprolactone, is gathered to dioxa degradable medical polyurethane Cyclohexanone and its copolymer (PPDO, PLA-PDO) are poly- to dioxa cyclohexanone(PPDO), polytrimethylene carbonate, poly- breast Acid-trimethylene carbonate copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid, polylactic acid-hydroxyl Acetic acid copolymer, polyether-ether-ketone, polyvinylpyrrolidone and/or polyethylene glycol, poly- valerolactone, poly- ε-decalactone, poly- friendship It is ester, polyglycolide, the copolymer of polyactide and polyglycolide, poly- ε-caprolactone, polyhydroxybutyrate, poly butyric ester, poly- Hydroxyl valerate, poly butyric ester-copolymerization-valerate, poly- (Isosorbide-5-Nitrae-dioxane -2,3- diketone), poly- (1,3- Dioxane -2- ketone), poly-p-dioxanone, polyanhydride (such as poly-maleic anhydride), poly- hydroxymethyl third Olefin(e) acid ester, polybutylcyanoacrylate, polycaprolactone dimethylacrylate, poly- β-maleic acid, gathers in oneself fibrin Ester butyl propyleneglycol acid esters, the multi-block polymer from oligomerization caprolactone diol and oligomerization dioxanone glycol, poly- second two Alcohol and polybutylene terephthalate)), it is poly- pivalolactone, polyglycolic acid carbonate, polycaprolactone-glycolide, poly- (γ-ethyl glutamate), poly- (DTH- iminocarbonic esters), poly- (DTE- copolymerization-DT- carbonic esters), poly- (bisphenol-A- Iminocarbonic ester), polyorthoester, polyglycolic acid carbonate, poly- trimethyl carbonate, poly- iminocarbonic ester, poly- (N- Vinyl) it is-pyrrolidones, polyvinyl alcohol, polyesteramide, dealing with alcohol polyester, polyphosphate, polyphosphazene, poly- [to carboxyl benzene oxygen Base) propane], poly- hydroxypentanoic acid, polyanhydride, polyethylene glycol oxide-propylene oxide, flexibel polyurethane, have amino acid residual in main chain The polyurethane of base, polyether ester (such as polyethylene glycol oxide), polyalkylene oxalate, polyorthoester and its copolymer, Irish moss Glue, fibrinogen, starch, collagen, containing protein polymer, polyaminoacid, synthesis polyaminoacid, zein, in The viscosity average molecular weigh of one kind, the biodegradable high molecular material is 500~1000000.
Wherein the material of degradable medical polyurethane is selected from polyether-type, polyester-polyether type, natural polymer subtype and plant The biodegradable PU of oil type, aliphatic poly ether urethane, polyurethane-acrylate hydrogel, fatty poly-ester carbonate urethane, Polyurethane-urea elastomers, polyurethane-polydimethylsiloxaneblock block copolymers, one kind in polyether thermoplastic polyurethane or Two kinds, specifically include the polyurethane that hard section is done with lysine diisocyanate, soft segment can be with polyalcohol, polyethylene glycol 200, One or more in polyethylene glycol 400, Macrogol 600 are initiator, one kind in LA, GA, CL, PDO, adipic anhydride or A variety of to obtain polymer diol, chain extension selecting is chosen in particular from ethylene glycol, two from chain extender diol or diamine or class diamine Glycol, tetraethylene glycol, 1,3- propylene glycol, Isosorbide-5-Nitrae-butanediol, 1,6- hexylene glycols, 1,7- heptandiols, 1,8- ethohexadiols, 1,9- One or both of nonanediol, 1,10- decanediols, ethylenediamine, propane diamine, butanediamine, pentanediamine, class diamine.
The one kind of the more preferable soft segment raw material of medical polyurethane diaphragm in polyurethane, polyester, polyethers, polyaminoacid Or two kinds of combinations, it is chosen in particular from poly- valerolactone, poly- ε-decalactone, polylactide, polyglycolide, polylactide and polyglycolide Copolymer, polylactide-co-glycolide copolymer, poly- 6-caprolactone, polyhydroxybutyrate, poly butyric ester, poly- hydroxyl penta Acid esters, gathers poly butyric ester -co- valerate(- dioxane -2,3- diketone of Isosorbide-5-Nitrae), it is poly-(1,3- dioxane -2- ketone), it is poly- P-dioxanone, polyanhydride, polymaleic anhydride, poly- hydroxyl-metacrylate, fibrin, polybutylcyanoacrylate, Polycaprolactone propylene dimethyl phthalate, poly- β-maleic acid, polycaprolactone butyl acrylate, by castor oil, the poly- hydroxyl of microbial fermentation Base butyric acid valerate(PHBV)With chemically synthesized polyvinyl alcohol(PVA), the bio-based polyurethane material of preparation, more block polymerizations Object is such as:From oligomerization caprolactone diol, oligomerization dioxanone glycol, polyether ester multi-block polymer, poly- pivalolactone, Polyglycolic acid trimethyl carbonate, gathers polycaprolactone-glycolide(G- ethyl glutamates), polyglycine, polyalanine, poly- figured silk fabrics ammonia Sour, poly- leucine, poly- isoleucine, polyphenylalanine and polyproline, poly- tryptophan, polyserine, polytyrosine, poly- half Guang Propylhomoserin, poly- methionine, poly-asparagine, polyglutamine and poly- threonine, poly-aspartate and polyglutamic acid, polylysine, Poly arginine and polyhistidyl or be different aminoacids polymer polypeptide, preferably with free amine group by basic amino acid Such as one or both of poly arginine, polylysine and the polyhistidyl combination being polymerized.
More preferable polylactic acid, polycaprolactone, is gathered to dioxa cyclohexanone and its copolymer degradable medical polyurethane (PPDO, PLA-PDO) is poly- to dioxa cyclohexanone(PPDO), polytrimethylene carbonate, polylactic acid-trimethylene carbonate One in copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid, polylactic acid-co-glycolic acid Kind, one or more of PLLA, PLA, PGA, PDO and PCL.
Polypeptide that is commercially available or having disclosed, albumen and active constituent can be added in polyurethane material, including Antiproliferative, anti-migration, anti-angiogenesis, anti-inflammatory, anti-inflammatory, cell growth inhibition, cytotoxicity antithrombotic have The drug of physiological activity.
Hydrophilic material can also be added, carbomer, Polycarbophil, Sodium Hyaluronate, sodium alginate, poly- ammonia are specifically included Base acid, polypeptide, povidone, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl starch, poly- second Enol, xanthans, modified alginates and its it is degraded into the alginate of aminohexose and N- acetylglucosamines, starch Grafted propylene nitrile, starch-grafted hydrophilic monomer, polyacrylate, vinyl acetate co-polymer, modified poly ethylene alcohols, fibre The plain grafted propylene nitrile of dimension, cellulose graft acrylates, cellulose xanthogenation grafted propylene hydrochlorate, cellulose graft acryloyl Epoxychloropropane intersects one or more combinations in crosslinking after amine, carboxymethyl cellulose.
Wherein, the material for preparing with body is non-degradable biomaterial.
Preferably, the non-degradable material is the mixing of one or more of titanium, gold, silver and nickel.
Wherein, it is described with body preparing material be degradable biomaterial in addition promote collagen growth various growths because Son or the drug for the treatment of aging.
The present invention also provides a kind of moulding process of the minimally invasive elevator belt of face, are one kind in following moulding process:
The first:Face minimally invasive elevator belt biomaterial is placed in 3D printer, design is then depicted in 3D printer The structure of the good minimally invasive elevator belt of face, directly prints;
Second:It is placed in designed mold, is molded after the minimally invasive elevator belt of face is melted with biomaterial;
The third:Flat wire is made with biomaterial in the minimally invasive elevator belt of face, is suppressed by grinding tool
4th kind:Band is made after the minimally invasive elevator belt of face is melted with biomaterial, is added by numerically-controlled machine tool or laser accurate Work forms;
5th kind:The minimally invasive elevator belt of face is dissolved or dispersed in biomaterial in organic solvent, colloidal sol is made, is placed in mold In be molded with.
The present invention also provides a kind of working methods of the minimally invasive elevator belt of face, include the following steps:
(1)A wherein minimally invasive elevator belt of face is placed in puncture needle, is implanted into along hair line by puncture needle;
(2)Two minimally invasive elevator belts of face separately are taken, by the fascia superficialis layer below the minimally invasive elevator belt implantation cheek of a wherein face The protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face is promptly integrally held skin by tissue, will be apart from hair line The protrusion indentation step of proximal end(1)In the connecting hole for the minimally invasive elevator belt of face being implanted into;By another minimally invasive elevator belt of face It is implanted into Face and cheek musculature, by the protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face, integrally holds skin, it will Protrusion indentation step apart from hair line proximal end(1)Face is realized in the connecting hole for the minimally invasive elevator belt of face being implanted into carry The effect risen.
The present invention also provides a kind of purposes of the minimally invasive elevator belt of face, are promoted for face lift, buttocks or human body needs Any position that shaping is promoted.
The above-mentioned technical proposal of the present invention has the beneficial effect that:The present invention provides it is a kind of it is simple in structure, easy to use, The minimally invasive elevator belt of face of good fixing effect, compared with prior art, the present invention solves staying after current hangnail line suspends in midair The end of a thread and fixed unstable clinical problem.
Description of the drawings
Fig. 1 is the front view of the embodiment of the present invention one;
Fig. 2 is the vertical view of embodiment one;
Fig. 3 is the front view of the embodiment of the present invention two;
Fig. 4 is the vertical view of embodiment two;
Fig. 5 is the front view of the embodiment of the present invention three;
Fig. 6 is the front view of the embodiment of the present invention four;
Fig. 7 is the front view of the embodiment of the present invention five;
Fig. 8 is the front view of the embodiment of the present invention six;
Fig. 9 is the front view of the embodiment of the present invention seven;
Figure 10 is the state diagram one when the present invention uses;
Figure 11 is the state diagram two when the present invention uses;
Figure 12 is the state diagram three when the present invention uses;
Figure 13 is the state diagram four when the present invention uses;
Figure 14 is the structure of protrusions of the present invention.
Reference sign:
1, band body;100, connecting hole;101, raised;2, the first bonding pad protrusion;3, the first lifting zone protrusion;4, the second bonding pad Protrusion;5, the second lifting zone protrusion;6, third bonding pad protrusion;7, third lifting zone protrusion;8, the 4th bonding pad protrusion;9, Four lifting zones protrusion;10, the 5th bonding pad protrusion;11, the 5th lifting zone protrusion.
Specific implementation mode
To keep the technical problem to be solved in the present invention, technical solution and advantage clearer, below in conjunction with attached drawing and tool Body embodiment is described in detail.
Embodiment 1
As shown in Figure 1 and Figure 2, the embodiment of the present invention provides a kind of minimally invasive elevator belt of face, includes the elongated straps body of tool thickness 1, multiple connecting holes 100 are distributed on the one side with body 1, multiple piercings facial fascia superficialis system is distributed on another side The protrusion 101 of system.
In the present embodiment, the connecting hole 100 is through the through-hole with body.
Each raised 101 structure snd size with 1 side of body are identical, and described raised 101 have can be inserted into through-hole And with the structure snd size of through-hole close-fitting.
Embodiment 2
As shown in Figure 3, Figure 4, the structure of the structure with embodiment 1 of the present embodiment is essentially identical, difference lies in:The band side side Multiple protrusions structure it is not exactly the same, multiple protrusions are divided into the first bonding pad protrusion 2 and the first lifting zone protrusion 3, described First bonding pad protrusion 2 have can be inserted into through-hole and with the structure snd size of through-hole close-fitting.Structure based on the present embodiment, first The size relative to the first lifting zone protrusion 3 that the size of bonding pad protrusion 2 can be done is small.
Embodiment 3
As shown in figure 5, the connecting hole with one side of body is blind hole.The blind hole is with the protrusion with another side of body in axial direction Upper coincidence.
In the present embodiment, the depth of the blind hole is more than the thickness with body, and the protrusion with side side is divided into the second company Connect area's protrusion 4 and the second lifting zone protrusion 5, the second bonding pad protrusion 4 have can be inserted into blind hole and with the knot of blind hole close-fitting Structure and size.The size of second bonding pad protrusion 4 is less than the size of the second lifting zone protrusion 5.
Embodiment 4
As shown in fig. 6, the connecting hole with one side of body is blind hole.The blind hole is with the protrusion with another side of body in axial direction Upper coincidence.
In the present embodiment, the depth of the blind hole is less than the thickness with body, and the protrusion with side side is divided into third company Connect area's protrusion 6 and third lifting zone protrusion 7, the third bonding pad protrusion 6 have can be inserted into blind hole and with the knot of blind hole close-fitting Structure and size.The size of third bonding pad protrusion 6 is much smaller than the size of third lifting zone protrusion 7.
Embodiment 5
As shown in fig. 7, the blind hole and the protrusion with another side of body are misaligned in the axial direction.
In the present embodiment, the depth of the blind hole is more than the thickness with body, the structure of each protrusion with side side with Size is identical, and it is described protrusion have can be inserted into blind hole and with the structure snd size of blind hole close-fitting.
Embodiment 6
As shown in figure 8, the blind hole and the protrusion with another side of body are misaligned in the axial direction.
In the present embodiment, the depth of the blind hole is more than the thickness with body, and the protrusion with side side is divided into the 4th company Connect area's protrusion 8 and the 4th lifting zone protrusion 9, the 4th bonding pad protrusion 8 have can be inserted into blind hole and with the knot of blind hole close-fitting Structure and size.The size of 4th bonding pad protrusion 8 is less than the size of the 4th lifting zone protrusion 9.
Embodiment 7
As shown in figure 9, the blind hole and the protrusion with another side of body are misaligned in the axial direction.
In the present embodiment, the depth of the blind hole is less than the thickness with body, and the protrusion with side side is divided into the 5th company Connect area's protrusion 10 and the 5th lifting zone protrusion 11, the 5th bonding pad protrusion 10 have can be inserted into blind hole and with blind hole close-fitting Structure snd size.
Hangnail can be arranged in the lower end outside of protrusion in the various embodiments described above, may be used such as Figure 14(a)-(h)Institute The structure shown.
In the present invention, the width with body is 0.01mm-100mm, thickness 0.01mm-10mm.It is preferred that the band body Width be 0. 1mm-10mm, thickness 0.05mm-3mm.
The material for preparing with body in the present invention is degradable biomaterial, or non-degradable biomaterial.
If degradable biomaterial, include the high molecular material of biological source and abiotic source, wherein
The high molecular material of the biological source includes:Collagen and its derivative, cellulose and its derivates, chitosan and its derivative Object, hyaluronic acid and its derivative;
The high molecular material in the abiotic source includes:Polylactic acid, polycaprolactone, is gathered to dioxa degradable medical polyurethane Cyclohexanone and its copolymer (PPDO, PLA-PDO) are poly- to dioxa cyclohexanone(PPDO), polytrimethylene carbonate, poly- breast Acid-trimethylene carbonate copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid, polylactic acid-hydroxyl Acetic acid copolymer, polyether-ether-ketone, polyvinylpyrrolidone and/or polyethylene glycol, poly- valerolactone, poly- ε-decalactone, poly- friendship It is ester, polyglycolide, the copolymer of polyactide and polyglycolide, poly- ε-caprolactone, polyhydroxybutyrate, poly butyric ester, poly- Hydroxyl valerate, poly butyric ester-copolymerization-valerate, poly- (Isosorbide-5-Nitrae-dioxane -2,3- diketone), poly- (1,3- Dioxane -2- ketone), poly-p-dioxanone, polyanhydride (such as poly-maleic anhydride), poly- hydroxymethyl third Olefin(e) acid ester, polybutylcyanoacrylate, polycaprolactone dimethylacrylate, poly- β-maleic acid, gathers in oneself fibrin Ester butyl propyleneglycol acid esters, the multi-block polymer from oligomerization caprolactone diol and oligomerization dioxanone glycol, poly- second two Alcohol and polybutylene terephthalate)), it is poly- pivalolactone, polyglycolic acid carbonate, polycaprolactone-glycolide, poly- (γ-ethyl glutamate), poly- (DTH- iminocarbonic esters), poly- (DTE- copolymerization-DT- carbonic esters), poly- (bisphenol-A- Iminocarbonic ester), polyorthoester, polyglycolic acid carbonate, poly- trimethyl carbonate, poly- iminocarbonic ester, poly- (N- Vinyl) it is-pyrrolidones, polyvinyl alcohol, polyesteramide, dealing with alcohol polyester, polyphosphate, polyphosphazene, poly- [to carboxyl benzene oxygen Base) propane], poly- hydroxypentanoic acid, polyanhydride, polyethylene glycol oxide-propylene oxide, flexibel polyurethane, have amino acid residual in main chain The polyurethane of base, polyether ester (such as polyethylene glycol oxide), polyalkylene oxalate, polyorthoester and its copolymer, Irish moss Glue, fibrinogen, starch, collagen, containing protein polymer, polyaminoacid, synthesis polyaminoacid, zein, in The viscosity average molecular weigh of one kind, the biodegradable high molecular material is 500~1000000.
Wherein the material of degradable medical polyurethane is selected from polyether-type, polyester-polyether type, natural polymer subtype and plant The biodegradable PU of oil type, aliphatic poly ether urethane, polyurethane-acrylate hydrogel, fatty poly-ester carbonate urethane, Polyurethane-urea elastomers, polyurethane-polydimethylsiloxaneblock block copolymers, one kind in polyether thermoplastic polyurethane or Two kinds, specifically include the polyurethane that hard section is done with lysine diisocyanate, soft segment can be with polyalcohol, polyethylene glycol 200, One or more in polyethylene glycol 400, Macrogol 600 are initiator, one kind in LA, GA, CL, PDO, adipic anhydride or A variety of to obtain polymer diol, chain extension selecting is chosen in particular from ethylene glycol, two from chain extender diol or diamine or class diamine Glycol, tetraethylene glycol, 1,3- propylene glycol, Isosorbide-5-Nitrae-butanediol, 1,6- hexylene glycols, 1,7- heptandiols, 1,8- ethohexadiols, 1,9- One or both of nonanediol, 1,10- decanediols, ethylenediamine, propane diamine, butanediamine, pentanediamine, class diamine.
The one kind of the more preferable soft segment raw material of medical polyurethane diaphragm in polyurethane, polyester, polyethers, polyaminoacid Or two kinds of combinations, it is chosen in particular from poly- valerolactone, poly- ε-decalactone, polylactide, polyglycolide, polylactide and polyglycolide Copolymer, polylactide-co-glycolide copolymer, poly- 6-caprolactone, polyhydroxybutyrate, poly butyric ester, poly- hydroxyl penta Acid esters, gathers poly butyric ester -co- valerate(- dioxane -2,3- diketone of Isosorbide-5-Nitrae), it is poly-(1,3- dioxane -2- ketone), it is poly- P-dioxanone, polyanhydride, polymaleic anhydride, poly- hydroxyl-metacrylate, fibrin, polybutylcyanoacrylate, Polycaprolactone propylene dimethyl phthalate, poly- β-maleic acid, polycaprolactone butyl acrylate, by castor oil, the poly- hydroxyl of microbial fermentation Base butyric acid valerate(PHBV)With chemically synthesized polyvinyl alcohol(PVA), the bio-based polyurethane material of preparation, more block polymerizations Object is such as:From oligomerization caprolactone diol, oligomerization dioxanone glycol, polyether ester multi-block polymer, poly- pivalolactone, Polyglycolic acid trimethyl carbonate, gathers polycaprolactone-glycolide(G- ethyl glutamates), polyglycine, polyalanine, poly- figured silk fabrics ammonia Sour, poly- leucine, poly- isoleucine, polyphenylalanine and polyproline, poly- tryptophan, polyserine, polytyrosine, poly- half Guang Propylhomoserin, poly- methionine, poly-asparagine, polyglutamine and poly- threonine, poly-aspartate and polyglutamic acid, polylysine, Poly arginine and polyhistidyl or be different aminoacids polymer polypeptide, preferably with free amine group by basic amino acid Such as one or both of poly arginine, polylysine and the polyhistidyl combination being polymerized.
More preferable polylactic acid, polycaprolactone, is gathered to dioxa cyclohexanone and its copolymer degradable medical polyurethane (PPDO, PLA-PDO) is poly- to dioxa cyclohexanone(PPDO), polytrimethylene carbonate, polylactic acid-trimethylene carbonate One in copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid, polylactic acid-co-glycolic acid Kind, one or more of PLLA, PLA, PGA, PDO and PCL.
Polypeptide that is commercially available or having disclosed, albumen and active constituent can be added in polyurethane material, including Antiproliferative, anti-migration, anti-angiogenesis, anti-inflammatory, anti-inflammatory, cell growth inhibition, cytotoxicity antithrombotic have The drug of physiological activity.
Hydrophilic material can also be added, carbomer, Polycarbophil, Sodium Hyaluronate, sodium alginate, poly- ammonia are specifically included Base acid, polypeptide, povidone, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl starch, poly- second Enol, xanthans, modified alginates and its it is degraded into the alginate of aminohexose and N- acetylglucosamines, starch Grafted propylene nitrile, starch-grafted hydrophilic monomer, polyacrylate, vinyl acetate co-polymer, modified poly ethylene alcohols, fibre The plain grafted propylene nitrile of dimension, cellulose graft acrylates, cellulose xanthogenation grafted propylene hydrochlorate, cellulose graft acryloyl Epoxychloropropane intersects one or more combinations in crosslinking after amine, carboxymethyl cellulose.
Can be titanium, gold, silver, nickel etc. if non-degradable biomaterial.
In the present invention, the material for preparing with body is the various lifes that addition promotes collagen growth in degradable biomaterial The long factor or the drug for treating aging.
The present invention also provides a kind of moulding process of the minimally invasive elevator belt of face, are one kind in following moulding process:
The first:Face minimally invasive elevator belt biomaterial is placed in 3D printer, design is then depicted in 3D printer The structure of the good minimally invasive elevator belt of face, degradable biomaterial is melted, by design structure printing shaping;
Second:It is placed in designed mold, is molded after the minimally invasive elevator belt of face is melted with biomaterial;
The third:Flat wire is made with biomaterial in the minimally invasive elevator belt of face, is suppressed by grinding tool
4th kind:Banded structure is made after the minimally invasive elevator belt of face is melted with biomaterial, passes through numerically-controlled machine tool or laser Precision Machining forms;
5th kind:The minimally invasive elevator belt of face is dissolved or dispersed in biomaterial in organic solvent, colloidal sol is made, is placed in mold In be molded with.
The present invention also provides a kind of working methods of the minimally invasive elevator belt of face, include the following steps:
(1)A wherein minimally invasive elevator belt of face is placed in puncture needle, is implanted into along hair line by puncture needle;
(2)Two minimally invasive elevator belts of face separately are taken, by the fascia superficialis layer below the minimally invasive elevator belt implantation cheek of a wherein face The protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face is promptly integrally held skin by tissue, will be apart from hair line The protrusion indentation step of proximal end(1)In the connecting hole for the minimally invasive elevator belt of face being implanted into;By another minimally invasive elevator belt of face It is implanted into Face and cheek musculature, by the protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face, integrally holds skin, it will Protrusion indentation step apart from hair line proximal end(1)Face is realized in the connecting hole for the minimally invasive elevator belt of face being implanted into carry The effect risen.Various status diagrams when face lift are as shown in Figure 10 ~ Figure 13.
The present invention also provides a kind of purposes of the minimally invasive elevator belt of face, are promoted for face lift, buttocks or human body needs Any position that shaping is promoted.
The effect further illustrated the present invention is tested below by being implanted under pigskin.
It is implanted into Germicidal efficacy under pigskin
The minimally invasive elevator belt of face that will be prepared using second and the third moulding process, uses oxirane disinfection.Select 6 bodies The pig of weight 20KG or so, respectively implantation are subcutaneously observed, every group 3.The swelling degree of postoperative routine observation subcutaneous location, blood Clear, histotomy observation.The experimental results showed that:The latter all inner skins of elevator belt implantation are locally general red, slight inflammation occur Reaction, inflammatory reaction after two weeks disappears, and after being implanted into 4 weeks, lift belt stimulates surrounding tissue fibroplasia, initially forms coating, group It is fine to knit compatibility.
The above described is only a preferred embodiment of the present invention, being not intended to limit the present invention in any form, appoint What those skilled in the art, without departing from the scope of the present invention, when in the technology using the disclosure above Hold the equivalent embodiment made a little change or be modified to equivalent variations, as long as being the content without departing from technical solution of the present invention, According to the technical essence of the invention to any simple modification, equivalent change and modification made by above example, this is still fallen within In the range of inventive technique scheme.

Claims (10)

1. a kind of minimally invasive elevator belt of face, which is characterized in that include the elongated straps body of tool thickness, on the one side with body Multiple connecting holes are distributed with, multiple protrusions for being pierced into facial fascia superficialis system are distributed on another side.
2. the minimally invasive elevator belt of face according to claim 1, which is characterized in that the connecting hole is through logical with body Hole.
3. the minimally invasive elevator belt of face according to claim 2, which is characterized in that the structure of each protrusion with side side It is identical with size, and the protrusion has the structure snd size that can be inserted into through-hole.
4. the minimally invasive elevator belt of face according to claim 1, which is characterized in that the connecting hole with one side of body is blind Hole.
5. the minimally invasive elevator belt of face according to claim 4, which is characterized in that the blind hole with the convex of another side of body It rises and overlaps in the axial direction.
6. the minimally invasive elevator belt of face according to claim 5, which is characterized in that the depth of the blind hole is less than the thickness with body Degree, the protrusion with side side are divided into third bonding pad protrusion and third lifting zone protrusion, third bonding pad protrusion tool The structure snd size of blind hole can be inserted by having.
7. the minimally invasive elevator belt of face according to any one of claim 1 ~ 6, which is characterized in that described to prepare material with body Material is degradable biomaterial,
The degradable biomaterial includes the high molecular material of biological source and abiotic source, wherein
The high molecular material of the biological source includes:Collagen and its derivative, chitosan and its derivative;
The high molecular material in the abiotic source includes:Polylactic acid, polycaprolactone, is gathered to dioxa degradable medical polyurethane Cyclohexanone and its copolymer gather to dioxa cyclohexanone, polytrimethylene carbonate, polylactic acid-trimethylene carbonate copolymerization One kind in object, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid, polylactic acid-co-glycolic acid, One or more of PLLA, PLA, PGA, PDO and PCL.
8. a kind of moulding process of the minimally invasive elevator belt of face, which is characterized in that for one kind in following moulding process:
The first:Face minimally invasive elevator belt biomaterial is placed in 3D printer, design is then depicted in 3D printer The structure of the good minimally invasive elevator belt of face, directly prints;
Second:It is placed in designed mold, is molded after the minimally invasive elevator belt of face is melted with biomaterial;
The third:Flat wire is made with biomaterial in the minimally invasive elevator belt of face, is suppressed by grinding tool
4th kind:Band is made after the minimally invasive elevator belt of face is melted with biomaterial, is added by numerically-controlled machine tool or laser accurate Work forms;
5th kind:The minimally invasive elevator belt of face is dissolved or dispersed in biomaterial in organic solvent, colloidal sol is made, is placed in mold In be molded with.
9. a kind of working method of the minimally invasive elevator belt of face, which is characterized in that include the following steps:
(1)A wherein minimally invasive elevator belt of face is placed in puncture needle, is implanted into along hair line by puncture needle;
(2)Two minimally invasive elevator belts of face separately are taken, by the fascia superficialis layer below the minimally invasive elevator belt implantation cheek of a wherein face The protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face is promptly integrally held skin by tissue, will be apart from hair line The protrusion indentation step of proximal end(1)In the connecting hole for the minimally invasive elevator belt of face being implanted into;By another minimally invasive elevator belt of face It is implanted into Face and cheek musculature, by the protrusion indentation tissue of the remote hairline line end of the minimally invasive elevator belt of face, integrally holds skin, it will Protrusion indentation step apart from hair line proximal end(1)Face is realized in the connecting hole for the minimally invasive elevator belt of face being implanted into carry The effect risen.
10. a kind of purposes of the minimally invasive elevator belt of face, which is characterized in that promoted for face lift, buttocks or human body needs are whole Any position that shape is promoted.
CN201810448698.1A 2018-05-11 2018-05-11 A kind of minimally invasive elevator belt of face, its moulding process and its working method Withdrawn CN108742945A (en)

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