CN108742588B - Pulse wave velocity detection method and device - Google Patents

Pulse wave velocity detection method and device Download PDF

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CN108742588B
CN108742588B CN201810325179.6A CN201810325179A CN108742588B CN 108742588 B CN108742588 B CN 108742588B CN 201810325179 A CN201810325179 A CN 201810325179A CN 108742588 B CN108742588 B CN 108742588B
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王磊
刘伟超
李迎新
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Institute of Biomedical Engineering of CAMS and PUMC
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics

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Abstract

The invention discloses a method and a device for detecting the wave velocity of a pulse wave, which relate to the technical field of biological medical treatment and comprise the following steps: the electrocardio-electrode is contacted with the skin of the corresponding position of the detected person through an electrocardio detection sensor to measure an electrocardio signal; respectively placing a two-channel pressure pulse wave sensor on the skin surfaces of the radial artery positions of the left wrist and the right wrist of the detected person to obtain a first pulse wave signal and a second pulse wave signal; measuring a photoplethysmography signal by a photoelectric sensor by adopting a conventional method based on photoplethysmography; establishing a pulse wave velocity calculation method based on the electrocardiosignals, the first pulse wave signals, the second pulse wave signals and the photoplethysmographic pulse wave signals; the technical problems that a detection device in the prior art is very high in difficulty in clinical operation, a technician needs to operate after professional training in the clinical measurement process, and related equipment is high in manufacturing cost are solved.

Description

Pulse wave velocity detection method and device
Technical Field
The invention relates to the technical field of medical instruments, in particular to a pulse wave velocity detection method and device.
Background
The prevalence trend of cardiovascular disease risk factors in China is becoming more obvious, and especially the aging of population and the acceleration of urbanization progress lead to the continuous increase of the number of patients with cardiovascular diseases. The Pulse Wave Velocity (PWV) is an important index for measuring arteriosclerosis, and the higher the degree of arteriosclerosis, the higher the pulse wave velocity.
The most representative of the current device for measuring the wave velocity of the pulse wave is the golden standard cervical femoral pulse wave conduction velocity CF-PWV which is the most authoritative arteriosclerosis detection internationally. In addition, CF-PWV is a measure of aortic elasticity, and peripheral vascular elasticity is not considered for measurement.
However, during the development process of the invention in the present application, the applicant of the present invention finds that the above prior art has at least the following technical problems: although the measurement of the conduction velocity of the carotid femoral artery based on the pressure pulse wave has been clinically accepted, the measurement is difficult in clinical operation, the measurement requires a trained technician to operate, and the related equipment is expensive.
Disclosure of Invention
The embodiment of the invention provides a pulse wave velocity detection method and a pulse wave velocity detection device, which are used for solving the technical problems that the detection device in the prior art is high in clinical operation difficulty, needs to be operated by a technologist after professional training in the clinical measurement process, and related equipment is high in cost, and the technical effects of comprehensively analyzing signals of cardiovascular electrocardio, photoelectric blood flow and pressure pulse waves at the same moment, calculating the pulse wave conduction velocity and providing a new means for evaluating clinical arteriosclerosis are achieved.
In one aspect, to solve the above problem, an embodiment of the present invention provides a pulse wave velocity detection method, including the following steps:
firstly, measuring an electrocardiosignal of a detected person through an electrocardio detection sensor;
secondly, measuring a photoplethysmogram signal at the left finger tip or a photoplethysmogram signal at the right finger tip of the detected person by adopting a method based on a photoplethysmogram through a photoelectric sensor;
thirdly, measuring a pressure pulse wave signal at the radial artery position of the left wrist or a pressure pulse wave signal at the radial artery position of the right wrist of the detected person through a pressure pulse wave sensor;
step four, obtaining a pulse wave velocity v according to the electrocardiosignal, the pulse wave signal and the photoplethysmography pulse wave signal and the formula (1):
Figure BDA0001626351830000011
in the formula (1), the reaction mixture is,
alpha is a weighting coefficient of pulse wave velocity of photoelectric volume pulse wave detection, and the value range of alpha is [0,1 ];
beta is a weighting coefficient of the wave velocity of the pressure pulse wave, and the value range of beta is [0,1 ];
S1from the photoelectric sensor measuring point to the heart of the detected person along the body surface of the detected personThe length of the location;
S2measuring the length from the pressure pulse wave sensor to the heart position of the detected person along the body surface of the detected person;
ΔT1the time difference between the electrocardiosignal wave crest and the photoelectric volume pulse wave signal wave crest corresponding to the electrocardiosignal wave crest is obtained;
ΔT2the time difference between the electrocardiosignal wave crest and the pressure pulse wave signal wave crest corresponding to the electrocardiosignal wave crest is obtained.
Furthermore, the pulse wave velocity detection method provided by the invention comprises the fourth step of detecting the time difference delta T between the electrocardiosignal wave crest and the photoelectric volume pulse wave signal wave crest corresponding to the electrocardiosignal wave crest1The calculation method comprises the following steps: and obtaining a peak time point of the photoplethysmography signal through the photoplethysmography signal, and calculating a time difference between the peak time point and an S wave inflection point of the electrocardiosignal.
In the fourth step, the time difference delta T between the electrocardiosignal wave crest and the pressure pulse wave signal wave crest corresponding to the electrocardiosignal wave crest2The calculation method comprises the following steps: and obtaining the peak time point of the pressure pulse wave signal through the pressure pulse wave signal, and calculating the time difference between the peak time point and the inflection point of the S wave of the electrocardiosignal.
In another aspect, the present invention further provides a pulse wave velocity detection apparatus, including: the device comprises an electrocardio detection sensor, a pressure pulse wave sensor, a photoelectric sensor, a signal processing module and a computer; the electrocardio detection sensor is used for acquiring electrocardiosignals; the pressure pulse wave sensor is used for acquiring pulse wave signals; the photoelectric sensor is used for collecting photoplethysmography signals; the input end of the signal processing module is respectively connected with the output ends of the electrocardio detection sensor, the pressure pulse wave sensor and the photoelectric sensor, and is used for receiving the electrocardio signals, the pulse wave signals and the photoelectric volume pulse wave signals; the input end of the computer is connected with the output end of the signal processing module, and the pulse wave velocity is obtained through calculation according to the digital signal obtained after the processing of the signal processing module; and simultaneously displaying the digital signal and the pulse wave velocity.
Further, the pulse wave velocity detection device provided by the invention is characterized in that the electrocardio detection sensor is a three-channel electrocardio detection sensor, and the pressure pulse wave sensor is a two-channel pressure pulse wave sensor; the signal processing module specifically comprises: the three-channel electrocardio front-end conditioning circuit is connected with the output end of the three-channel electrocardio detection sensor; the photoelectric and double-channel pulse wave front conditioning circuit is respectively connected with the output ends of the double-channel pressure pulse wave sensor and the photoelectric sensor; the input end of the first ADC module is connected with the output end of the three-channel electrocardio front-end conditioning circuit, and the received analog signal is converted into a digital signal and output; the input end of the second ADC module is connected with the output end of the photoelectric and double-channel pulse wave front end conditioning circuit, and the received analog signals are converted into digital signals and output; the input end of the single chip microcomputer is connected with the output ends of the first ADC module and the second ADC module, the output end of the single chip microcomputer is connected with the input end of the computer, and the single chip microcomputer receives the digital signal and inputs the digital signal to the computer; and the power supply circuit is connected with the three-channel electrocardio front-end conditioning circuit, the photoelectric and double-channel pulse wave front-end conditioning circuit and the singlechip and provides electric power for the three-channel electrocardio front-end conditioning circuit, the photoelectric and double-channel pulse wave front-end conditioning circuit and the singlechip.
Compared with the prior art, the invention has the beneficial effects that:
(1) the embodiment of the invention provides a pulse wave velocity detection method, which comprises the steps of contacting an electrocardio electrode with the skin of a detected person at a corresponding position through an electrocardio detection sensor to obtain an electrocardio signal; respectively placing a two-channel pressure pulse wave sensor on the skin surfaces of the radial artery positions of the left wrist and the right wrist of the detected person to obtain a first pulse wave signal and a second pulse wave signal; measuring a photoplethysmography signal by a photoelectric sensor by adopting a conventional method based on photoplethysmography; and obtaining a pulse wave velocity detection result based on the electrocardio signal, the first pulse wave signal, the second pulse wave signal and the photoplethysmographic pulse wave signal. The technical problems that a detection device in the prior art is very difficult in clinical operation, a technician needs to operate after professional training in the clinical measurement process, and related equipment is expensive in manufacturing cost are solved, the comprehensive analysis of signals of cardiovascular electrocardio, photoelectric blood flow and pressure pulse waves at the same moment is realized, the pulse wave conduction velocity is calculated, and a new means is provided for the evaluation of clinical arteriosclerosis.
(2) The embodiment of the invention adopts a conventional method based on photoelectric volume pulse waves by adopting a photoelectric sensor, solves the technical problems that a detection device in the prior art is very difficult in clinical operation, needs to be operated by a technologist after professional training in the clinical measurement process, and related equipment is high in cost, and achieves the technical effects that a probe for measuring by a photoelectric method is small and exquisite, the flexibility is good, the skin measurement mode is diversified in noninvasive placement, the anti-interference capability is strong compared with the pressure pulse wave measurement mode, and the clinical operability is better.
(3) The embodiment of the invention further achieves the technical effects that the measurement dimensionality of a photoelectric method is increased by adding the method for monitoring the pulse wave conduction velocity through the photoelectric volume pulse wave, and the measurement of the photoelectric peripheral blood vessel blood flow signal enables the system measurement method to consider the peripheral blood vessel sclerosis degree.
(4) The embodiment of the invention achieves the technical effects of improving the accuracy of the conduction speed and reducing the system error through multi-mode multi-point measurement and model correction.
Drawings
FIG. 1 is a flow chart of a method for detecting a pulse wave velocity according to the present invention;
FIG. 2 is a schematic diagram of a method for detecting a pulse wave velocity according to the present invention;
FIG. 3 is a schematic diagram of the pulse wave velocity detecting apparatus according to the present invention;
FIG. 4 is a diagram illustrating the definition of the time difference in the method of the present invention.
Reference numerals: 1-electrocardio electrode, 2-double channel pressure pulse wave sensor, 3-photoelectric blood flow detection probe, 4-signal processing module, 5-computer, 6-display, 7-electrocardio signal, 8, 9-pressure pulse wave signal and 10-photoelectric volume pulse wave signal.
Detailed Description
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.
The embodiment of the invention provides a pulse wave velocity detection method and device, and solves the technical problems that a detection device in the prior art is very difficult in clinical operation, needs to be operated by a technologist after professional training in the clinical measurement process, and related equipment is high in manufacturing cost.
The invention provides a pulse wave velocity detection method, which is designed according to the following idea: the electrocardio-electrode is contacted with the skin of the corresponding position of the detected person through an electrocardio detection sensor to measure an electrocardio signal; placing a pressure pulse wave sensor on the surface of the skin of the radial artery of the left or right wrist of the detected person to measure a pulse wave signal; measuring a photoplethysmography signal by a photoelectric sensor by adopting a conventional method based on photoplethysmography; and finally calculating to obtain the pulse wave velocity through the mathematical model for calculating the pulse wave velocity established by the invention based on the electrocardio signal, the pulse wave signal and the photoplethysmography pulse wave signal. The pulse wave velocity detection method comprises the following specific steps:
firstly, measuring an electrocardiosignal of a detected person through an electrocardio detection sensor;
secondly, measuring a photoplethysmogram signal at the left finger tip or a photoplethysmogram signal at the right finger tip of the detected person by adopting a method based on a photoplethysmogram through a photoelectric sensor;
thirdly, measuring a pressure pulse wave signal at the radial artery position of the left wrist or a pressure pulse wave signal at the radial artery position of the right wrist of the detected person through a pressure pulse wave sensor;
step four, obtaining a pulse wave velocity v according to the electrocardiosignal, the pulse wave signal and the photoplethysmography pulse wave signal and the formula (1):
Figure BDA0001626351830000041
in the formula (1), the reaction mixture is,
alpha is a weighting coefficient of pulse wave velocity of photoelectric volume pulse wave detection, and the value range of alpha is [0,1 ];
beta is a weighting coefficient of the wave velocity of the pressure pulse wave, and the value range of beta is [0,1 ];
S1the length from a photoelectric sensor measuring point to the heart position of a detected person along the body surface of the detected person;
S2measuring the length from the pressure pulse wave sensor to the heart position of the detected person along the body surface of the detected person;
ΔT1the time difference between the electrocardiographic signal peak and the photoplethysmography signal peak corresponding to the electrocardiographic signal peak is shown in fig. 4, in the present invention, the peak time point of the photoplethysmography signal is obtained from the photoplethysmography signal, and the time difference between the peak time point and the inflection point of the electrocardiographic signal S wave is calculated.
ΔT2The time difference between the electrocardiographic signal peak and the pressure pulse wave signal peak corresponding to the electrocardiographic signal peak is shown in fig. 4, in the present invention, the peak time point of the pressure pulse wave signal is obtained from the pressure pulse wave signal, and the time difference between the peak time point and the inflection point of the S wave of the electrocardiographic signal is calculated.
In a preferred embodiment of the present invention, a plurality of weight variables may be introduced to improve accuracy and reduce system errors, for example, the pressure pulse wave sensor in the present invention is preferably a two-channel pressure pulse wave sensor, the two-channel pressure pulse wave sensor is respectively disposed on the skin surfaces of the radial artery of the left wrist and the right wrist of the detected person to measure a first pulse wave signal and a second pulse wave signal; measuring a photoplethysmography signal by a photoelectric sensor by adopting a conventional method based on photoplethysmography; and calculating the pulse wave velocity by using a mathematical model for calculating the pulse wave velocity according to the electrocardio signal, the first pulse wave signal, the second pulse wave signal and the photoplethysmographic pulse wave signal.
Figure BDA0001626351830000042
Wherein alpha is a weighting coefficient of the pulse wave velocity of the photoplethysmography pulse wave detection; beta is a1A weighting coefficient for the first pulse wave signal; beta is a2A weighting coefficient for the first pulse wave signal; s1The length from a photoelectric sensor measuring point to the heart position of a detected person along the body surface of the detected person; s2And S3The lengths from the measuring points of the two-channel pressure pulse wave sensor to the heart position of the detected person along the body surface of the detected person are respectively.
The two-channel pressure pulse wave sensor is adopted to realize the comprehensive analysis of the signals of the cardiovascular electrocardio, the photoelectric blood flow and the pressure pulse wave at the same moment, calculate the pulse wave conduction velocity and provide a new means for the evaluation of clinical arteriosclerosis.
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
An embodiment of the present invention provides a method for detecting a pulse wave velocity, please refer to fig. 1, where the method includes:
the classical principle of pulse wave velocity is determined by measuring the body surface distance L and the pulse wave transit time PTT of the arterial segment, PWV L/PTT. The existing acknowledged mature measurement technical means is to measure the conduction velocity of the cervical and femoral pulse waves through the pressure pulse waves, and because the pressure pulse wave measurement mode has the defects of difficult fixation and easy interference, the measurement parts of the neck and the femoral artery are special and complicated, the operation requirement is very high, and the clinical practicability is relatively insufficient.
Based on the pulse wave velocity, the invention provides a method for comprehensively analyzing and calculating the conduction velocity based on signals of electrocardio, photoelectric blood flow and pressure pulse waves, and deriving the pulse wave velocity by acquiring the electrocardio, photoelectric pulse waves and the pressure pulse waves through a multi-mode sensor. The implementation mode adopts three-lead electrocardio-electrode, a single photoelectric volume pulse wave sensor and a double-channel pressure pulse wave sensor, and the working principle and the implementation steps are as follows:
step 110: the electrocardio-electrode is contacted with the skin of the corresponding position of the detected person through an electrocardio detection sensor to measure an electrocardio signal;
further, the electrocardiosignal obtained by the electrocardio-electrode is subjected to Q-R-S detection to obtain a signal inflection point S, and the moment is recorded as the starting point of the pulse wave conduction time.
Specifically, the electrocardio acquisition modes comprise single lead, standard three lead, standard five lead and standard twelve lead; the present invention preferably utilizes a three lead electrocardio-electrode. The electrocardio-electrode 1 comprises three-lead electrocardio-electrode plates, namely LL, LA and RA, wherein the electrode LL is placed at the intersection point between the 6 th rib and the 7 th rib of the left clavicle midline, the electrode LA is placed at the intersection point between the left clavicle midline and the 2 nd rib, the electrode RA is placed at the intersection point between the right clavicle midline and the 2 nd rib, and the electrode plates are tightly attached to the skin after the skin cuticle is removed to measure electrocardio signals. The Q-R-S detection is electrocardiographic waveform inflection point detection.
Step 120: respectively placing a two-channel pressure pulse wave sensor on the skin surfaces of the radial artery positions of the left wrist and the right wrist of the detected person to obtain a first pulse wave signal and a second pulse wave signal;
further, a peak time point P1 of the first pulse wave signal 8 is obtained, and a time difference DeltaT between the peak time point P1 and an S-wave inflection point of the electrocardiosignal 7 is calculated2(ii) a Obtaining the peak time point P2 of the second pulse wave signal 9, and calculating the time difference delta T between the peak time point P2 and the inflection point of the electrocardio signal S wave3. As shown in fig. 4.
Specifically, the two-channel pressure pulse wave sensor is respectively disposed on the skin surface of the radial artery of the left wrist and the right wrist of the person to be detected, and one pulse wave signal is measured from the left hand, and one pulse wave signal is measured from the right hand, that is, the first pulse wave signal and the second pulse wave signal, where the first pulse wave signal may be a signal measured from the left hand or a signal measured from the right hand, and the second pulse wave signal may be a signal measured from the left hand or a signal measured from the right hand, and only for distinguishing the two obtained pulse wave signals, which is the left hand to obtain the pulse wave signal is not particularly limited.
Step 130: measuring a photoplethysmography signal by a photoelectric sensor by adopting a conventional method based on photoplethysmography;
further, a peak time point P3 of the photoplethysmographic signal 10 is obtained, and a time difference Delta T between the peak time point P3 and an inflection point of an S wave of the electrocardiosignal is calculated1。
Specifically, the photoelectric blood flow detection probe of the photoelectric sensor is in close contact with a skin surface region where peripheral blood vessels are abundant. Preferably, the part is the tip of the index finger, the earlobe and the middle of the forehead of the head.
Step 140: obtaining a calculation result of the pulse wave velocity based on the electrocardio signal, the first pulse wave signal, the second pulse wave signal and the photoplethysmographic pulse wave signal:
Figure BDA0001626351830000061
wherein alpha is a weighting coefficient of the pulse wave velocity of the photoplethysmography pulse wave detection; beta is a1Is the first pulse wave signalA weighting factor for the number; beta is a2A weighting coefficient for the first pulse wave signal; s1Measuring the body surface distance between the site and the heart for the electrocardio detection sensor; s2Measuring the body surface distance between a site and the heart for the two-channel pressure pulse wave sensor; s3And measuring the body surface distance between the site and the heart for the photoelectric sensor. Alpha weighting coefficient value range [0,1]]The value range of the weighting coefficient of beta is [0,1]]。
Further, a calculation model of the pulse wave velocity is established through a gold standard of the pulse wave velocity measurement, and weight coefficients alpha and beta are deduced and determined1、β2。
Specifically, based on the synchronous measurement signals of three sensors in multiple modes, a calculation model of PWV is established:
Figure BDA0001626351830000062
wherein alpha and beta are undetermined coefficients, alpha is a weighting coefficient of the wave velocity of the pulse wave detected by the photoplethysmography pulse wave, and beta is a weighting coefficient of the wave velocity of the pressure pulse wave; s1 and S2 are the lengths of the measuring points of the sensors from the blood vessels of the heart respectively.
The PWV detection method is characterized in that the gold standard measured by PWV is as follows: measuring pulse wave propagation velocity v by ultrasonic DopplersBased on gold standard experimental data v of testersEstablishing a PWV calculation model with the S/delta T value corresponding to the tester, and deducing and determining the weight coefficients alpha and beta;
the weighting factor S/delta T of the PWV is not limited to be formed by a photoelectric sensor and a pressure sensor, and the calculation model can be perfected by adding corresponding weighting factors through adding a plurality of sensors; the calculation model formed by the two photoelectric sensors and the two pressure sensors is as follows:
Figure BDA0001626351830000063
wherein alpha is1Detecting the calculated pulse for one of the photosensorsWave velocity weighting coefficient, alpha2Detecting and calculating a pulse wave velocity weighting coefficient for another photoelectric sensor; beta is a1Pulse wave velocity weighting coefficient, beta, calculated for the detection of one of the pressure sensors2Detecting a calculated pulse wave velocity weighting coefficient for another pressure sensor; wherein alpha is1、α2The value range of the weighting coefficient (0, 1)]，β1、β2The value range of the weighting coefficient (0, 1)](ii) a S1, S2, S3 and S4 are the distances between the measurement site of each sensor and the body surface of the heart respectively.
Example two
The present invention also provides a device for detecting the wave velocity of a pulse wave, as shown in fig. 2 and 3, the device comprising:
the electrocardio detection sensor is a three-channel electrocardio detection sensor, the input end of the electrocardio detection sensor is connected with an electrocardio electrode 1, and the electrocardio electrode 1 is contacted with the chest of a detected person to acquire electrocardio signals;
the pressure pulse wave sensor is a two-channel pressure pulse wave sensor 2, the input end of the two-channel pressure pulse wave sensor 2 is contacted with the skin surfaces of the subject at the radial artery positions of the left wrist and the right wrist of the subject, and a first pulse wave signal and a second pulse wave signal are acquired; the input end of the photoelectric sensor is contacted with the skin of the index finger of the detected person to acquire a photoplethysmographic signal; and the input end of the signal processing module 4 is respectively connected with the output ends of the electrocardio detection 4 sensor, the two-channel pressure pulse wave sensor 2 and the photoelectric sensor, and is used for receiving the electrocardio signals, the first pulse wave signals, the second pulse wave signals and the photoplethysmography signals.
The electrocardio-electrode 1 with three leads arranged on a tested person is arranged in front of the chest and used for collecting electrocardiosignals, and the signals collected by the three electrocardio-electrodes 1 are input into the signal processing module 4; the double-channel pressure sensor 2 arranged on a measured person is used for detecting pulse waves, and pulse wave signals measured by the double-channel pressure pulse wave sensor 2 are input to the signal processing module 4; a photoelectric blood flow detection probe 3 of the photoelectric sensor and pulse wave signals collected by the two-channel pressure sensor 2 are input into a signal processing module 4 through a lead; the signal processing module 4 is connected with the computer 5 and is communicated through a serial port, the computer 5 integrates the three kinds of information, the cardiovascular parameter PWV is processed and calculated, and the cardiovascular parameter, the electrocardiogram and the photoplethysmography waveform and the pressure pulse waveform are displayed on the display interactive device.
The electrocardio-electrode 1 comprises three-lead electrocardio-electrode plates, namely LL, LA and RA, wherein the electrode LL is placed at the intersection point between the ribs 6 and 7 on the left clavicle midline, the electrode LA is placed at the intersection point between the left clavicle midline and the rib 2, the electrode RA is placed at the intersection point between the right clavicle midline and the rib 2, and the electrode plates are tightly attached to the skin after the skin cuticle is removed and are respectively connected to the cardiac signal processing module 4 through three leads.
The double-channel pressure pulse wave sensors 2 are respectively arranged at the radial artery parts of the left hand and the right hand, are fixed by using wrist straps, apply pressure and adjust the pressure to enable pulse wave signals to be stably output, and are respectively connected to the signal processing module 4 through two leads; the photoelectric blood flow detection probe 3 is tightly attached to the palm surface of the finger tip of the index finger and is connected to the signal processing module 4 together with the pressure pulse wave signal through a lead.
Further, the signal processing module 4 specifically includes: the three-channel electrocardio front-end conditioning circuit is connected with the output end of the electrocardio detection sensor and receives the electrocardio signal 7; the photoelectric and double-channel pulse wave front end conditioning circuit is respectively connected with the double-channel pressure pulse wave sensor 2 and the output end of the photoelectric sensor, receives the first pulse wave signal, the second pulse wave signal and the photoelectric volume pulse wave signal and is connected with the output end of the three-channel electrocardio front end conditioning circuit, and the input end of the first ADC module is connected with the output end of the three-channel electrocardio front end conditioning circuit, converts the received analog signal into a digital signal and outputs the digital signal; the input end of the second ADC module is connected with the output end of the photoelectric and double-channel pulse wave front end conditioning circuit, and the received analog signals are converted into digital signals and output; the input end of the single chip microcomputer is connected with the output ends of the first ADC module and the second ADC module, the output end of the single chip microcomputer is connected with the input end of the computer, and the single chip microcomputer receives the digital signal and inputs the digital signal to the computer; and the power supply circuit is connected with the three-channel electrocardio front-end conditioning circuit, the photoelectric and double-channel pulse wave front-end conditioning circuit and the singlechip and provides electric power for the three-channel electrocardio front-end conditioning circuit, the photoelectric and double-channel pulse wave front-end conditioning circuit and the singlechip. The input end of the computer 5 is connected with the output end of the signal processing module 4, and the pulse wave velocity is obtained according to the electrocardio signal, the first pulse wave signal, the second pulse wave signal and the photoplethysmography pulse wave signal; the computer 5 includes a display 6 for displaying the electrocardiographic signal, the first pulse wave signal and the second pulse wave signal, the photoplethysmographic pulse wave signal, and the final calculation result.
Specifically, the signal processing module comprises a three-channel electrocardio front-end conditioning circuit, a photoelectric and two-channel pulse wave front-end conditioning circuit, two same ADC modules, a single chip microcomputer and a power supply circuit. The signal of the pressure pulse wave front end conditioning circuit is input and connected by the pressure pulse wave sensors of the two channels and the photoelectric blood flow detection probe together, and is connected with the ADC module; the electrocardio front-end conditioning circuit is connected with the three electrocardio electrodes through leads to input signals and is connected with the ADC module; the two ADC modules are connected with the single chip microcomputer for data communication. The single chip microcomputer is communicated with an upper computer through a serial port protocol of a USB.
The serial port protocol of the single chip microcomputer and the upper computer is as follows: the USB full duplex serial communication interface is adopted, 1 start bit, 8 data bits, 1 stop bit and no parity bit, and the baud rate is 115200 bps. Format of data frame transmitted: uint8buf [12] = {0xf0,0x00,0x00,0x00,0x00,0x00,0x00,0x00,0x00,0xff,0xff,0xff }, wherein 0xf0 is the data frame header, and wherein the 10 th, 11 th, 12 th byte 0xff,0xff,0xff is the end frame character; start sampling, feature code: 0xfa, off sample, feature code: 0 xff. The 2 nd and 3 rd bytes are respectively the eight high bits and the eight low bits of the electrocardio signals, the 4 th and 5 th bytes are respectively the eight high bits and the eight low bits of the pulse wave sensor channel 1 signals, the 6 th and 7 th bytes are respectively the eight high bits and the eight low bits of the pulse wave sensor channel 2 signals, and the 8 th and 9 th bytes are respectively the eight high bits and the eight low bits of the photoelectric pulse wave signals.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made in the embodiments of the present invention without departing from the spirit or scope of the embodiments of the invention. Thus, if such modifications and variations of the embodiments of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to encompass such modifications and variations.

Claims (3)

1. A pulse wave velocity detection method is characterized by comprising the following steps:
firstly, measuring an electrocardiosignal of a detected person through an electrocardio detection sensor;
secondly, measuring a photoplethysmogram signal at the left finger tip or a photoplethysmogram signal at the right finger tip of the detected person by adopting a method based on a photoplethysmogram through a photoelectric sensor;
thirdly, measuring a pressure pulse wave signal at the radial artery position of the left wrist or a pressure pulse wave signal at the radial artery position of the right wrist of the detected person through a pressure pulse wave sensor;
step four, obtaining a pulse wave velocity v according to the electrocardiosignal, the pressure pulse wave signal and the photoplethysmography pulse wave signal and the formula (1):
Figure FDA0002666612520000011
in the formula (1), the reaction mixture is,
alpha is a weighting coefficient of pulse wave velocity of photoelectric volume pulse wave detection, and the value range of alpha is [0,1 ];
beta is a weighting coefficient of the wave velocity of the pressure pulse wave, and the value range of beta is [0,1 ];
S1the length from a photoelectric sensor measuring point to the heart position of a detected person along the body surface of the detected person;
S2measuring the length from the pressure pulse wave sensor to the heart position of the detected person along the body surface of the detected person;
ΔT1the time difference between the electrocardiosignal wave crest and the photoelectric volume pulse wave signal wave crest corresponding to the electrocardiosignal wave crest is obtained;
ΔT2the time difference between the electrocardiosignal wave crest and the pressure pulse wave signal wave crest corresponding to the electrocardiosignal wave crest is obtained;
gold standard by pulse wave velocity measurement: measuring pulse wave propagation velocity v by ultrasonic DopplersBased on gold standard experimental data v of testersAnd establishing a calculation model of the pulse wave velocity corresponding to the S/delta T value of the tester, and deducing and determining the weighting coefficients alpha and beta.
2. The method for detecting a pulse wave velocity according to claim 1, wherein in the fourth step, a time difference Δ T between the peak of the electrocardiographic signal and the peak of the photoplethysmographic pulse wave signal corresponding to the peak of the electrocardiographic signal is set to be smaller than a predetermined value1The calculation method comprises the following steps: and obtaining a peak time point of the photoplethysmography signal through the photoplethysmography signal, and calculating a time difference between the peak time point and an S wave inflection point of the electrocardiosignal.
3. The method for detecting a pulse wave velocity according to claim 1, wherein in the fourth step, a time difference Δ T between the electrocardiographic signal peak and the pressure pulse wave signal peak corresponding to the electrocardiographic signal peak is set to2The calculation method comprises the following steps: obtaining the peak time point of the pressure pulse wave signal through the pressure pulse wave signal, and calculating the peakThe time difference between the time point and the inflection point of the S wave of the electrocardiosignals.
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