CN108742585A - A kind of rheohepatogram measuring device - Google Patents
A kind of rheohepatogram measuring device Download PDFInfo
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- CN108742585A CN108742585A CN201810415136.7A CN201810415136A CN108742585A CN 108742585 A CN108742585 A CN 108742585A CN 201810415136 A CN201810415136 A CN 201810415136A CN 108742585 A CN108742585 A CN 108742585A
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- rheohepatogram
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0536—Impedance imaging, e.g. by tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
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- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Psychiatry (AREA)
- Radiology & Medical Imaging (AREA)
- Mathematical Physics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Measurement Of Resistance Or Impedance (AREA)
Abstract
The invention discloses a kind of rheohepatogram measuring devices, including：The output end of driving voltage generation module is connected with the in-phase input end of amplifier；The inverting input of amplifier and the collector of the first end of current-limiting resistance and triode extremely connect altogether；The second end of current-limiting resistance is connected with isolated power supply；The output end of amplifier and the base stage of triode connect；The emitter of triode is electrically connected with human body；The signal obtained through two path electrodes and bucking electrode line measurement is sent into amplification/AD conversion module, and the output end of amplification/AD conversion module is connected with processor；Current measurement circuit one end is connected with human body, and the other end is connected with processor；The signal that processor measures the signal and current measurement circuit that are handled by amplification/AD conversion module carries out Fourier analysis, seeks body complex impedance.The present invention is converted into current excitation by the way of current excitation, by voltage drive, in conjunction with four-probe measurement method, effectively increases measurement accuracy.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of rheohepatogram measuring device.
Background technology
Rheohepatogram needs to measure the capacitive reactance of liver and current-limiting resistance, the variation of wherein capacitive reactance and current-limiting resistance are very micro-
Small, measurement accuracy is most important.Currently, existing rheohepatogram measuring instrument precision is relatively low；And general rheohepatogram measuring instrument is
Desktop computer, the big power consumption of volume is high, expensive.
Therefore, how to provide a kind of rheohepatogram measuring device of high certainty of measurement is those skilled in the art's urgent need to resolve
The problem of.
Invention content
In view of this, the present invention provides a kind of rheohepatogram measuring device, measurement accuracy is effectively increased.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of rheohepatogram measuring device, including：Driving voltage generation module, operational amplifier, triode, current limliting electricity
Resistance, amplification/AD conversion module, current measurement circuit and processor；
Under the control of the processor, the output end of the driving voltage generation module is same with the operational amplifier
Phase input terminal is connected；
The inverting input of the operational amplifier and the first end of the current-limiting resistance and the current collection of the triode
Pole extremely connects altogether；Wherein, the second end of the current-limiting resistance is connected with isolated power supply；
The output end of the operational amplifier is connect with the base stage of the triode；The emitter of the triode passes through screen
It covers electrode wires and electrode is connected with human body；
The signal feeding amplification/AD conversion module obtained through two path electrodes and bucking electrode line measurement, the amplification/
The output end of AD conversion module is connected with the processor；
Described current measurement circuit one end is connected by bucking electrode line and electrode with human body, the other end and the processor
It is connected；
The processor is respectively to the signal handled by the amplification/AD conversion module and the current measurement circuit
The signal measured carries out Fourier analysis, and seeks the complex impedance of human body.
Preferably, further include：The output device being connected with the processor.
Preferably, the electrode uses hypopolarization electrode.
Preferably, the bucking electrode line uses high-performance shielding line.
Preferably, the electrode being connected with the current measurement circuit is using floating ground earthing mode.
It can be seen via above technical scheme that compared with prior art, the present disclosure provides a kind of surveys of rheohepatogram
Amount device will be converted into current excitation by voltage drive, in conjunction with four-probe measurement in the prior art by the way of current excitation
Method can effectively remove the error of electrode-human contact's resistance, further increase measurement accuracy.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 attached drawings are the structural schematic diagram of rheohepatogram measuring device provided by the invention；
Fig. 2 attached drawings are rheohepatogram measurement result figure provided by the invention；
Fig. 3 attached drawings are contact impedance error result figure provided by the invention；
Fig. 4 attached drawings are resistance relative accuracy result figure provided by the invention；
Fig. 5 attached drawings are resistance noise virtual value result figure provided by the invention；
Fig. 6 attached drawings are capacitance relative accuracy result figure provided by the invention；
Fig. 7 attached drawings are capacitor noise virtual value result figure provided by the invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Referring to attached drawing 1, the embodiment of the invention discloses a kind of rheohepatogram measuring devices, including：Driving voltage generates mould
Block, operational amplifier, triode, current-limiting resistance, amplification/AD conversion module, current measurement circuit and processor；
Under the control of a processor, the in-phase input end phase of the output end of driving voltage generation module and operational amplifier
Even；Wherein, driving voltage generation module can generate the driving voltage of random waveform under the action of processor.
The inverting input of operational amplifier and the collector of the first end of current-limiting resistance and triode extremely connect altogether；Its
In, the second end of current-limiting resistance is connected with isolated power supply；
The output end of operational amplifier and the base stage of triode connect；The emitter of triode passes through bucking electrode line and electricity
Pole is connected with human body；
The signal obtained through two path electrodes and bucking electrode line measurement is sent into amplification/AD conversion module, amplification/AD conversion mould
The output end of block is connected with processor；
Current measurement circuit one end is connected by bucking electrode line and electrode with human body, and the other end is connected with processor；
The signal that processor respectively measures the signal and current measurement circuit that are handled by amplification/AD conversion module
Fourier analysis is carried out, and seeks the complex impedance of human body.
In the prior art, the measurement method of rheohepatogram is voltage drive, but electrode, bucking electrode in measurement process
All there is resistance in line and human body, it may appear that pressure drop, it is difficult to accurately control, cause measurement accuracy low.And the present invention uses electric current
The mode of excitation will be converted into current excitation to improve measurement accuracy by voltage drive in the prior art.Because electric current is on human body
It flows through and not will change, so as to ensure measurement accuracy.In conjunction with four-probe measurement method, electrode-people can be effectively removed
The error of body contact resistance, further increases measurement accuracy.
In addition, amplification/AD conversion module amplified signal can inhibit noise as far as possible, in conjunction in Fu in processor
Leaf transformation analyzes human body equivalent circuit, further increases the signal-to-noise ratio of system.
In specific implementation, low-power scm may be used in processor, to reduce the power consumption of whole device.
In order to advanced optimize above-mentioned technical proposal, further include：The output device being connected with processor, such as：Display
Device and/or printer, export measurement result so that measurement result is more intuitive, and staff is facilitated to check.
In order to advanced optimize above-mentioned technical proposal, electrode uses hypopolarization electrode.
In order to advanced optimize above-mentioned technical proposal, bucking electrode line uses high-performance shielding line.
High performance bucking electrode line and electrode can effectively remove the power frequency common mode interference in space and eliminate polarization electricity
Difference is held up, the accurate of measurement result is further ensured.
In order to advanced optimize above-mentioned technical proposal, the electrode being connected with current measurement circuit is using floating ground earthing mode.
Rheohepatogram measuring device final system dynamic range provided by the invention is more than 100dB, collected hepatic blood flow
Figure is very clear, as a result refers to attached drawing 2.
High-precision rheohepatogram measuring device can obtain the material particular of clinical needs, the phase that 100 ohm of the present apparatus pair
100dB, RMS AC noise 2 milliohms of maximum are reached to measurement accuracy；97dB is reached to the capacitance measurement relative accuracy of 5.6nF, together
When being measured to 100 Ohmic resistances, for 1400 ohmic contact resistances error inhibit within 0.2%, ensureing
Exciting current can be arranged in 425uA hereinafter, greatly ensure that somatometric safety in the case of measurement accuracy.
It is only 3cm*5cm, precision and pole of the power consumption less than 2 milliwatts and superelevation that the present invention, which designs the device volume completed,
Low exciting current, overall performance have reached international most advanced level.
In order to verify the measurement accuracy of liver blood flow map device, the contact impedance error of the present apparatus, pure electricity are tested respectively
The measurement accuracy of resistance and purely capacitive measurement accuracy.
(1) contact impedance error
When measuring human body, skin contact impedance and conductor impedance are readily incorporated error.Exciting current is set in 100uA,
PGA uses tri- driving frequencies of 10kHz, 30kHz and 50kHz to measure the impedance of 100 Ω resistance respectively at 1 times.Service precision
5% resistance simulation contact impedance selects 0 Ω, 100 Ω, 470 Ω, 1000 Ω, the resistance of 1400 Ω respectively.Measurement result is such as
Fig. 3, the error caused by contact impedance is in ± 0.2% range；The obtained results of wherein 10kHz and 30kHz essentially coincide,
Absolutely prove that device performance provided by the invention is excellent.
(2) resistance capacitance relative accuracy
Exciting current is set in 425uA, uses the resistance that PGA gains are 9 times of measurements, one 100 Ω precision 0.5%.It uses
The ratio of the coefficient of variation, the i.e. standard deviation of measurement result and mean value carrys out the dispersion degree of apparatus for evaluating measurement result.It is used when measurement
500uA exciting currents are encouraged, exciting signal frequency is since 5kHz and with the stepping measurement of 5kHz to 50kHz.As a result such as Fig. 4 institutes
Show.Within the scope of 5kHz to 50kHz pumping signals, relative accuracy can reach -93dB.5kHz to 20kHz pumping signal ranges
Interior, relative accuracy can up to arrive -100dB.
The RMS AC noise of 1000 measurement results is counted, the results are shown in Figure 5.Believe as it can be seen that being encouraged in 5kHz to 50kHz
Within the scope of number, the RMS AC noise of measurement result is 2m Ω.
5.6nF capacitances, relative measurement are tested with the stepping measurement of 5kHz to 50kHz from 30kHz using exciting current frequency
(RMS AC noise is minimum reachable as shown in Fig. 6 (relative accuracy reaches as high as -97dB) and Fig. 7 respectively for precision and RMS AC noise
50mΩ)。
Each embodiment is described by the way of progressive in this specification, the highlights of each of the examples are with other
The difference of embodiment, just to refer each other for identical similar portion between each embodiment.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so description is fairly simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (5)
1. a kind of rheohepatogram measuring device, which is characterized in that including：Driving voltage generation module, operational amplifier, three poles
Pipe, current-limiting resistance, amplification/AD conversion module, current measurement circuit and processor；
Under the control of the processor, the output end of the driving voltage generation module is same mutually defeated with the operational amplifier
Enter end to be connected；
The inverting input of the operational amplifier and the first end of the current-limiting resistance and the collector pole of the triode
It connects altogether；Wherein, the second end of the current-limiting resistance is connected with isolated power supply；
The output end of the operational amplifier is connect with the base stage of the triode；The emitter of the triode is by shielding electricity
Polar curve and electrode are connected with human body；
The signal obtained through two path electrodes and bucking electrode line measurement is sent into the amplification/AD conversion module, and the amplification/AD turns
The output end of mold changing block is connected with the processor；
Described current measurement circuit one end is connected by bucking electrode line and electrode with human body, the other end and the processor phase
Even；
The processor respectively measures the signal handled by the amplification/AD conversion module and the current measurement circuit
The signal arrived carries out Fourier analysis, and seeks the complex impedance of human body.
2. rheohepatogram measuring device according to claim 1, which is characterized in that further include：It is connected with the processor
The output device connect.
3. rheohepatogram measuring device according to claim 1, which is characterized in that the electrode uses hypopolarization electrode.
4. rheohepatogram measuring device according to claim 1, which is characterized in that the bucking electrode line uses high-performance
Shielding line.
5. rheohepatogram measuring device according to claim 1, which is characterized in that be connected with the current measurement circuit
Electrode is using floating ground earthing mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810415136.7A CN108742585A (en) | 2018-05-03 | 2018-05-03 | A kind of rheohepatogram measuring device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810415136.7A CN108742585A (en) | 2018-05-03 | 2018-05-03 | A kind of rheohepatogram measuring device |
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| CN108742585A true CN108742585A (en) | 2018-11-06 |
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| CN201810415136.7A Pending CN108742585A (en) | 2018-05-03 | 2018-05-03 | A kind of rheohepatogram measuring device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109452936A (en) * | 2018-12-15 | 2019-03-12 | 浙江大学台州研究院 | Breathing and heart stroke combined monitoring equipment |
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2018
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| CN1114174A (en) * | 1994-05-23 | 1996-01-03 | 姚雪祥 | Automatic analyzing and diagnosing method and apparatus for hemotachogram |
| CN1528239A (en) * | 2003-10-15 | 2004-09-15 | 精量电子（深圳）有限公司 | Body resistance measuring circuit |
| CN1836627A (en) * | 2006-04-18 | 2006-09-27 | 云南大学 | Frequency conversion type chopping zero digital liver resistance blood stream instrument |
| CN101194836A (en) * | 2006-12-05 | 2008-06-11 | 重庆博恩富克医疗设备有限公司 | Method and device for eliminating interference in bio-electrical impedance measurement |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109452936A (en) * | 2018-12-15 | 2019-03-12 | 浙江大学台州研究院 | Breathing and heart stroke combined monitoring equipment |
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Application publication date: 20181106 |