CN108721651A - The preparation facilities of lipid ultrasonic microbubble contrast agent - Google Patents
The preparation facilities of lipid ultrasonic microbubble contrast agent Download PDFInfo
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- CN108721651A CN108721651A CN201810681911.3A CN201810681911A CN108721651A CN 108721651 A CN108721651 A CN 108721651A CN 201810681911 A CN201810681911 A CN 201810681911A CN 108721651 A CN108721651 A CN 108721651A
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- contrast agent
- tube body
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- 239000002872 contrast media Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 150000002632 lipids Chemical class 0.000 title claims abstract description 26
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960004065 perflutren Drugs 0.000 claims abstract description 28
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 22
- 239000010959 steel Substances 0.000 claims abstract description 22
- 238000007789 sealing Methods 0.000 claims abstract description 14
- 230000000694 effects Effects 0.000 claims abstract description 6
- 230000000712 assembly Effects 0.000 claims description 9
- 238000000429 assembly Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 241000486406 Trachea Species 0.000 claims description 6
- 210000003437 trachea Anatomy 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000009738 saturating Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 239000007789 gas Substances 0.000 description 53
- 239000003153 chemical reaction reagent Substances 0.000 description 19
- 238000002604 ultrasonography Methods 0.000 description 8
- 238000000605 extraction Methods 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 108010056388 Albunex Proteins 0.000 description 2
- 108010008908 FS 069 Proteins 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JRHNUZCXXOTJCA-UHFFFAOYSA-N 1-fluoropropane Chemical compound CCCF JRHNUZCXXOTJCA-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- -1 Sonovue Chemical compound 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004088 pulmonary circulation Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Abstract
The invention discloses a kind of preparation facilities of lipid ultrasonic microbubble contrast agent, including connecting seat, seal assembly, perfluoropropane gas steel cylinder, piston component, vacuum pump and needle body；Connecting seat includes connecting plate and the tube body set on its bottom, and tube body upper end is connected to the insert port on connecting plate, and outer wall is equipped with graduation mark；Seal assembly includes top plate, guide sleeve, bottom plate and ball sealer, and top plate and bottom plate are set in tube body, and top plate is equipped with first through hole, bottom plate is equipped with the second through-hole, and guide sleeve is set between top plate and bottom plate, and outer wall is equipped with third through-hole, ball sealer is set in guide sleeve, for sealing first through hole；Perfluoropropane gas steel cylinder is connected to tube body；Piston component is set in tube body, for extracting perfluoropropane gas, and first through hole is opened when moving downwardly to extreme position；Vacuum pump is connected to tube body；Needle body is connected to tube body.Effect：It is simple in structure, it is easy to operate, facilitate the contrast agent for preparing plurality of specifications, there is larger promotional value.
Description
Technical field
The present invention relates to the preparation facilities field of the super shadow agent of ultrasound more particularly to a kind of systems of lipid ultrasonic microbubble contrast agent
Standby device.
Background technology
Lipid ultrasonic microbubble contrast agent (Ultrasound contrast agent), which is one kind, can significantly increase ultrasound backwards
The chemicals of scattering strength.Has the history in more than 30 years about the research of ultrasound microbubble contrast agent both at home and abroad at present.It is main
Ingredient is microbubble, and general a diameter of 2-10um can pass through pulmonary circulation.A point generation for contrast agent is mainly according to microvesicle at present
The type of interior package gas divides.First generation contrast agent microbubble includes air, and coating is generally albumin or galactolipin etc.
Condensate.The physical characteristic of first generation acoustic contrast agent, including coating are thicker, poor flexibility, and the air wrapped up is soluble easily in water
Deng, determine that its duration is short, be easily broken, to limit in clinical application observe and diagnose time.The first generation is made
Shadow agent includes Albunex, Echo-vist (SHU-454) and Levovist (SHU-508A), and second generation contrast agent includes
Optison, Sonovue, Sonazoid etc..Second generation acoustic contrast agent is that package high density inert gas (is not readily dissolved at present
Water or blood) based on the thin pliable bubble of outer membrane, for diameter generally in 2-5um or so, stabilization time is long, and vibration and echo are special
Property is good.Albunex and Optison ratifies clinical application by U.S. FDA, and Echovist and Levovist are faced by Europe approval
Bed application may be implemented radiography using above-mentioned acoustic contrast agent and image, also known as acoustic contrast (acoustic contrast),
Resolving power, the sensibility and specificity of Ultrasonic Diagnosis can be significantly improved after use.Improvement with instrument performance and novel acoustic
The appearance of contrast agent, ultrasonic contrast can effectively enhance the parenchymatous organs such as cardiac muscle, liver, kidney, brain two-dimensional ultrasound image and
Blood flow doppler signal, the blood perfusion situation of reflection and observation normal structure and pathological tissues, it has also become the one of Ultrasonic Diagnosis
A particularly significant and up-and-coming developing direction.It is widely clinical at present to be used, and it is mostly used in clinical ultrasound
Microbubble contrast agent has following deficiency：Expensive, working condition storage time is short.In recent years, acoustic contrast agent is super in treatment
The application in sound field also has begun to be studied.Since microbubble can generate cavitation effect under the action of ultrasound in acoustic contrast agent
It answers, to generate a series of biological effects, therefore acoustic contrast agent conveys (drug in ultrasound thrombolysis, mediation gene transfer, drug
Delivery) and on the orientation treatments such as High Intensity Focused Ultrasound (Hifu) also there are many exciting experimental studies.Ultrasonic contrast
The application range of agent constantly expands, and application value is constantly promoted.
By the research of a large amount of domestic and foreign scholars, a variety of microbubble contrast agents for scientific research have been produced, and have been made
Standby mode is also varied, and existing preparation method mostly uses greatly hand gun ventilation, and prepared lipid ultrasonic is micro-
Concentration, the purity for steeping contrast agent is not high, while influence of the human factor to result is also very big, is unfavorable for the preparation of contrast agent.
Invention content
The present invention is directed to solve at least some of the technical problems in related technologies.For this purpose, the present invention
Purpose is to propose a kind of preparation facilities of lipid ultrasonic microbubble contrast agent.
To achieve the above object, the preparation facilities of lipid ultrasonic microbubble contrast agent according to the ... of the embodiment of the present invention, including：
Connecting seat, the connecting seat include connecting plate and multiple tube bodies, on the connecting plate it is evenly spaced offer it is more
A insert port, the evenly spaced lower surface for being set to the connecting plate of the multiple tube body, upper end are inserted with the multiple respectively
Entrance is connected to, and is evenly provided with a plurality of graduation mark on outer wall, and offer first interface and second interface；
Multiple seal assemblies, the multiple seal assembly are respectively arranged in the multiple tube body, each sealing group
Part includes top plate, guide sleeve, bottom plate and ball sealer, the top plate and bottom plate is opposing upper and lower is set in the tube body, and
Between first interface and second interface, bottom plate is located at below second interface top plate, the upper surface of the top plate with it is described more
The zero graduation line of graduation mark is flush, and the center of top plate offers a first through hole, the marginal position of the bottom plate
Multiple second through-holes are offered, the guide sleeve is set between the top plate and bottom plate, and upper end is connect with the top plate, under
End is connect with the bottom plate, offers multiple third through-holes on outer wall, and the ball sealer passes through the bullet that is set on the bottom plate
Property part is installed in the guide sleeve, and leads to the sealing top dome as described first when elastic component is not by outer force effect
Hole, so as to seal the first through hole；
Perfluoropropane gas steel cylinder, the perfluoropropane gas steel cylinder pass through multiple first tracheaes and the first interface phase
Connection, and one end that each first tracheae closes on the first interface is provided with the first valve；
Multiple piston components, the multiple piston component is drawable respectively to be set in the multiple tube body, for taking out
The gas in the perfluoropropane gas steel cylinder is taken, when the piston component moves downwardly to extreme position, lower end stretches to
Ball sealer described in the interior and downward ejection of the first through hole, so as to open the first through hole；
Vacuum pump, the vacuum pump are connected by multiple second tracheaes with second interface, and each second tracheae
On close on one end of the second interface and be provided with the second valve；
Multiple needle bodies, the multiple needle body are connected by hose with the lower end of multiple tube bodies respectively.
The preparation facilities of the lipid ultrasonic microbubble contrast agent provided according to embodiments of the present invention, including connecting seat, Duo Gemi
Sealing assembly, perfluoropropane gas steel cylinder, multiple piston components, vacuum pump and multiple needle bodies, connecting seat include connecting plate and are set to
Multiple tube bodies of its bottom, tube wall are equipped with graduation mark, and multiple seal assemblies are respectively arranged in multiple tube bodies, including top plate,
Guide sleeve, bottom plate and ball sealer, top plate and bottom plate are set in tube body, and guide sleeve is set between top plate and bottom plate, close
Blocking is installed on by elastic component in guide sleeve, for sealing the first through hole on top plate, perfluoropropane gas steel cylinder and true
Sky pump is connected with tube body, and multiple gas fill assemblies are drawable respectively to be installed in multiple tube bodies, for extracting perfluor
Gas in propane gas steel cylinder, and first through hole can be opened when being moved down into extreme position, multiple needle bodies and tube body phase
Connection；In this way, when carrying out the preparation of lipid ultrasonic microbubble contrast agent, using vacuum pump vacuum action, vacuum degree may make
Effect higher is conducive to the purity for improving contrast agent；Certain perfluoropropane gas is extracted using what multiple piston components can quantify
Body, and be delivered in corresponding reagent bottle, in order to prepare the contrast agent of identical or different volume, while the present invention as needed
It is simple in structure, it is easy to use, there is larger promotional value.
In addition, the preparation facilities of lipid ultrasonic microbubble contrast agent according to the above embodiment of the present invention can also have it is as follows
Additional technical characteristic：
Further include the component that is locked according to one embodiment of present invention, the component that is locked includes first
Fixed plate, the second fixed plate, transverse slat and locking member；
First fixed plate and the second fixed plate or so are oppositely arranged, and the lower end of the first fixed plate and the connecting plate
Left end vertical connection, upper end is parallel with connecting plate, the right end vertical connection of the lower end of the second fixed plate and the connecting plate, on
End is parallel with connecting plate, and the upper end of first fixed plate and the second fixed plate offers threaded hole；
Offer multiple sets of holes on the transverse slat, the multiple sets of holes and multiple insert ports on the connecting plate one by one on
It is lower opposite, and the piston component is arranged in respectively in the multiple sets of holes；
There are two the locking member settings, and two locking members are threadedly coupled with two threaded holes respectively, and position
Between left fixed plate and right fixed plate.
According to one embodiment of present invention, the piston component includes piston body and push rod；
The piston body includes piston head and mandril, and the push rod is connected with the upper end of the piston head, for driving
It states piston head to move up and down in the tube body, the mandril is connected with the lower end of the piston head, and the outer diameter of mandril is less than
The internal diameter of the first through hole；
When the push rod drives the piston head to move downwardly to extreme position, the mandril stretches into the first through hole
It is interior, and ball sealer described in ejection downwards, so as to open the first through hole.
According to one embodiment of present invention, the internal diameter of multiple insert ports is adapted with the outer diameter of the push rod,
And it is provided with sealing ring on the inner wall of each insert port.
Further include mounting base according to one embodiment of present invention, the mounting base includes left plate, right plate,
One support plate and the second support plate；
The lower end of the left plate and right plate is connected with the left and right ends of first support plate respectively, described second
Fagging is oppositely arranged up and down with first support plate, and both ends are connected with the left plate and right plate respectively, upper surface
Centre position offers a mounting hole；
The vacuum pump is installed on the left end of the upper surface of second support plate, the perfluoropropane gas steel cylinder installation
Right end in the upper surface of second support plate；The connecting seat is installed in the mounting hole.
According to one embodiment of present invention, it is provided with a fixed seat in first support plate, in the fixed seat
Multiple slots are offered, vibrator is installed in each slot.
According to one embodiment of present invention, the tube body is made of clear material.
According to one embodiment of present invention, the ball sealer is made of metal or plastic material.
Description of the drawings
Fig. 1 is overall structure diagram of the embodiment of the present invention；
Fig. 2 is the sectional view of the embodiment of the present invention；
Fig. 3 is the sectional view of seal assembly of the embodiment of the present invention.
Reference numeral：
Connecting seat 10；
Connecting plate 11；
Sealing ring 111；
Tube body 12；
First interface 121；
Second interface 122；
Seal assembly 20；
Top plate 21；
First through hole 211；
Bottom plate 22；
Second through-hole 221；
Elastic component 222；
Guide sleeve 23；
Third through-hole 231；
Ball sealer 24；
Perfluoropropane gas steel cylinder 30；
First tracheae 31；
First valve 311；
Piston component 40；
Push rod 41；
Piston body 42；
Piston head 421；
Mandril 422；
Vacuum pump 50；
Second tracheae 51；
Second valve 511；
Needle body 60；
Hose 61；
Be locked component 70；
First fixed plate 71；
Second fixed plate 72；
Transverse slat 73；
Locking member 74；
Mounting base 80；
Left plate 81；
Right plate 82；
First support plate 83；
Fixed seat 831；
Second support plate 84；
Reagent bottle 90.
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific implementation mode
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.
In the description of the present invention, it is to be understood that, term "center", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of
The description present invention and simplified description, do not indicate or imply the indicated device or element must have a particular orientation, with spy
Fixed azimuth configuration and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more this feature.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can be machine
Tool connects, and can also be electrical connection；It can be directly connected, can also can be indirectly connected through an intermediary two members
Connection inside part.For the ordinary skill in the art, above-mentioned term can be understood in this hair as the case may be
Concrete meaning in bright.
Shown in Fig. 3, an embodiment of the present invention provides a kind of preparation facilities of lipid ultrasonic microbubble contrast agent,
Including connecting seat 10, multiple seal assemblies 20, perfluoropropane gas steel cylinder 30, multiple piston components 40, vacuum pump 50 and multiple
Needle body 60.
Specifically, connecting seat 10 includes connecting plate 11 and multiple tube bodies 12, on connecting plate 11 it is evenly spaced offer it is more
A insert port, the evenly spaced lower surface for being set to connecting plate 11 of multiple tube bodies 12, upper end are connected to multiple insert ports respectively,
It is evenly provided with a plurality of graduation mark on outer wall, and offers first interface 121 and second interface 122；Its a plurality of graduation mark institute
Corresponding scale value is gradually reduced from top to bottom.
Multiple seal assemblies 20 are respectively arranged in multiple tube bodies 12, and each seal assembly 20 includes top plate 21, guide sleeve
Pipe 23, bottom plate 22 and ball sealer 24, top plate 21 and bottom plate 22 is opposing upper and lower is set in tube body 12, and top plate 21 is located at first
Between interface 121 and second interface 122, bottom plate 22 is located at 122 lower section of second interface, the upper surface of top plate 21 and a plurality of graduation mark
Zero graduation line be flush, and the center of top plate 21 offers a first through hole 211, the lower half portion of first through hole 211
Inner wall be the globoidal structure to match with ball sealer 24, and sealing rubber ring is provided on inner wall, the marginal position of bottom plate 22
Multiple second through-holes 221 are offered, guide sleeve 23 is set between top plate 21 and bottom plate 22, and upper end is connect with top plate 21, under
End is connect with bottom plate 22, offers multiple third through-holes 231 on outer wall, and ball sealer 24 passes through the elastic component that is set on bottom plate 22
222 are installed in guide sleeve 23, and push up ball sealer 24 as first through hole 211 when elastic component 222 is not by outer force effect,
To be aligned with the sealing rubber ring on the inner wall of first through hole 211, to be sealed to first through hole 211.
Preferably, spring can be used in elastic component 222, and the internal diameter of guide sleeve 23 is interior slightly larger than ball sealer 24
Diameter, in this way, i.e. can ensure that ball sealer 24 be accurately against first through hole 211 under the action of the spring and to first through hole
211 are sealed, meanwhile, metal can be used in ball sealer 24 or plastic material is made.
Perfluoropropane gas steel cylinder 30 is connected by multiple first tracheaes 31 with first interface 121, and each first gas
One end that pipe 31 closes on first interface 121 is provided with the first valve 311；It is loaded with perfluoropropane in perfluoropropane gas steel cylinder 30
Gas, and it is connected with the first interface 121 on tube body 12, in this way, perfluoropropane gas can pass through the first tracheae 31 and
One interface 121 enters in tube body 12, and the first valve 311 on the first tracheae 31 is for being turned on and off the first tracheae 31.
Multiple piston components 40 are drawable respectively to be set in multiple tube bodies 12, for extracting perfluoropropane gas steel cylinder
Gas in 30, when piston component 40 moves downwardly to extreme position, lower end stretches in first through hole 211 and downward ejection
Ball sealer 24, so as to open first through hole 211；
Preferably, tube body 12 is made of transparent material, consequently facilitating the position of observation piston component 40, so that ginseng
According to the gas of volume needed for scale line extraction.Also, the first interface 121 on tube body 12 closes on the setting of top plate 21, in piston group
Part 40 moves downwardly to salable first interface 121 when extreme position, while opening first through hole 211, and works as piston component 40
When moving downward and sealing first through hole 211 by ball sealer 24, open open the first valve 311 in the state of, can will be complete
Gas in fluoro-propane gas bomb 30 is pumped into the first tube body 12.
Vacuum pump 50 is connected by multiple second tracheaes 51 with the second interface 122 on tube body 12, and each second gas
One end that second interface 122 is closed on pipe 51 is provided with the second valve 511；That is, vacuum pump 50 by the second tracheae 51,
Second interface 122, the second through-hole 221, hose 61 and syringe needle and be connected with the reagent bottle 90 being connected on syringe needle, therefore,
When opening vacuum pump 50, and opening the second valve 511 on the second tracheae 51, reagent bottle 90 can be vacuumized.
More specifically, when preparing lipid ultrasonic microbubble contrast agent using the present invention：
The clear hydrated liquid of preparation is added to the reagent that specification is identical or specification is different first with the prior art
In bottle 90；Then multiple needle bodies 60 are inserted into respectively in multiple reagent bottles 90, close the first valve 311 on the first tracheae 31,
The valve on the second tracheae 51 is opened, while opening first through hole 211, vacuum pump 50 is then opened and vacuumizes the present invention
Processing；After the completion of extraction, the second valve 511 is closed, first through hole 211 is maintained at air-tight state, is then turned on the first valve
311, the perfluoropropane gas of required volume is extracted with reference to the scale on multiple tube bodies 12 and using multiple piston components 40；Into one
Step closes the first valve 311, pushes down on piston component 40 to open first through hole 211, the gas in tube body 12 is expelled to
In the space of 21 lower section of top plate in tube body 12, since reagent bottle 90 is vacuum state, from the interior perfluor third being discharged of tube body 12
Alkane gas can enter in reagent bottle 90；Vacuumize process is carried out again according to above-mentioned steps, after the completion of extraction, again according to
The gas of volume, precipitates a period of time, you can obtain lipid ultrasonic microbubble contrast agent needed for above-mentioned steps injection after concussion.
In above-mentioned preparation process, vacuum is extracted using vacuum pump 50, relative to manual withdrawal, vacuum degree higher is more effortless,
Correspondingly, the contrast agent purity higher prepared.When needing the amount of lipid ultrasonic microbubble contrast agent to be prepared identical, reagent bottle 90
Identical specification can be used, correspondingly, i.e. using the injection in the identical reagent bottle 90 of multiple specifications of multiple piston components 40
The gas of required volume, to meet the preparation of contrast agent；And when needing lipid ultrasonic microbubble contrast agent amount difference to be prepared, examination
Agent bottle 90 then uses different specifications, then, it can utilize piston component 40 respectively in the different reagent bottle 90 of multiple specifications
The gas for injecting respective volume, to meet the preparation of contrast agent, in this way, this reality is novel can to prepare more parts of phases according to actual conditions
The contrast agent of same volume, can also prepare the contrast agent of more parts of different volumes.
It should be noted that in the gas being discharged in tube body 12, it may in the space of 21 lower section of top plate in tube body 12
Remain certain gas, this portion gas does not enter in reagent bottle 90, therefore, can cause to enter to the gas in reagent bottle 90
The amount of body is not sufficient enough, and the purity to influence the contrast agent prepared therefore, can be in advance to tube body 12 when designing tube body 12
The volume in the interior space in 21 lower section of top plate carries out constant volume setting, and reference volume 5ml illustratively prepares contrast agent institute
The gas needed is 20ml, and the volume in tube body 12 in the space of 21 lower section of top plate is 5ml, then being extracted using piston component 40
When gas, the gas volume of extraction can be 26~28ml, in this way, can ensure the gas in reagent bottle 90 close to 20ml,
In this way, can either ensure that the gas in reagent bottle 90 is sufficient enough, and excessive waste will not be caused.Certainly, the reference volume
It is the smaller the better.
The preparation facilities of the lipid ultrasonic microbubble contrast agent provided according to embodiments of the present invention, including connecting seat 10, it is multiple
Seal assembly 20, perfluoropropane gas steel cylinder 30, multiple piston components 40, vacuum pump 50 and multiple needle bodies 60, connecting seat 10 wrap
Connecting plate 11 and multiple tube bodies 12 set on its bottom are included, 12 outer wall of tube body is equipped with graduation mark, and multiple seal assemblies 20 are set respectively
In in multiple tube bodies 12, including top plate 21, guide sleeve 23, bottom plate 22 and ball sealer 24, top plate 21 and bottom plate 22 are set to pipe
In body 12, guide sleeve 23 is set between top plate 21 and bottom plate 22, and ball sealer 24 is installed on guide sleeve by elastic component 222
In 23, for sealing the first through hole 211 on top plate 21, perfluoropropane gas steel cylinder 30 and vacuum pump 50 are connected with tube body 12
Logical, multiple gas fill assemblies are drawable respectively to be installed in multiple tube bodies 12, for extracting perfluoropropane gas steel cylinder 30
In gas, and first through hole 211 can be opened when being moved down into extreme position, multiple needle bodies 60 are connected with tube body 12；
In this way, when carrying out the preparation of lipid ultrasonic microbubble contrast agent, using 50 vacuum action of vacuum pump, vacuum degree degree may make more
Height is conducive to the purity for improving contrast agent；The certain perfluoropropane gas of extraction that can be quantified using multiple piston components 40, and
It is delivered in corresponding reagent bottle 90, in order to the contrast agent of more parts of identical or different volumes of degree of preparation as needed, while this
Inventive structure is simple, easy to use, has larger promotional value.
Further include the component 70 that is locked in the example of the present invention, the component 70 that is locked includes the first fixation
Plate 71, the second fixed plate 72, transverse slat 73 and locking member 74；
First fixed plate 71 and the second fixed plate 72 or so are oppositely arranged, and the lower end of the first fixed plate 71 and connecting plate 11
Left end vertical connection, upper end is parallel with connecting plate 11, the lower end of the second fixed plate 72 and the right end vertical connection of connecting plate 11,
Upper end is parallel with connecting plate 11, and the upper end of the first fixed plate 71 and the second fixed plate 72 offers threaded hole；
Multiple sets of holes are offered on transverse slat 73, multiple sets of holes are opposite up and down one by one with multiple insert ports on connecting plate 11,
And multiple piston components 40 are arranged in respectively in multiple sets of holes；
There are two the settings of locking member 74, and two locking members 74 are threadedly coupled with two threaded holes respectively, and is located at left fixation
Between plate and right fixed plate.
That is, multiple gas fill assemblies are both connected on transverse slat 73, transverse slat 73 is moved up or down, it can be simultaneously
Multiple piston components 40 are driven to move synchronously, in this way, multiple piston components 40 can be driven simultaneously by downward operation transverse slat 73
Move downwardly to extreme position and open first through hole 211, meanwhile, by locking member 74 to the left and right ends of transverse slat 73 generate to
Under active force, you can multiple piston components 40 are maintained at the extreme position, will be in it in order to operate piston component 40
Gas be injected into reagent bottle 90, conversely, can drive multiple piston components 40 separate simultaneously by operating transverse slat 73 upwards
First through hole 211 and by ball sealer 24 seal first through hole 211, in this way convenient for staff operation.
In the example of the present invention, piston component 40 includes piston body 42 and push rod 41；
Piston body 42 includes piston head 421 and mandril 422, and push rod 41 is connected with the upper end of piston head 421, for driving work
Chock plug 421 moves up and down in tube body 12, and mandril 422 is connected with the lower end of piston head 421, and the outer diameter of mandril 422 is less than the
The internal diameter of one through-hole 211；
When push rod 41 drives piston head 421 to move downwardly to extreme position, mandril 422 stretches into first through hole 211, and
Downward ejection ball sealer 24, so as to open first through hole 211.
In this way, when using driving piston head 421 to move downwardly to extreme position using push rod 41, on piston head 421
Mandril 422 stretches into first through hole 211 and open-top ball sealer 24, in order to which gas is entered to from first through hole 211 in reagent bottle 90,
Meanwhile piston head 421 is offseted with 21 upper surface of top plate, is completely discharged so as to the gas of extraction when moving to extreme position,
It avoids remaining.
In another example of the present invention, the internal diameter of multiple insert ports is adapted with the outer diameter of push rod 41, and each slotting
Sealing ring 111 is provided on the inner wall of entrance.
Can so secondary seal be carried out to tube body 12, prevent that gas leak phenomenon occurs using process.
Further include mounting base 80 in some examples of the present invention, mounting base 80 includes left plate 81, right plate 82, the
One support plate 83 and the second support plate 84；
The lower end of left plate 81 and right plate 82 is connected with the left and right ends of the first support plate 83 respectively, the second support plate 84
It is oppositely arranged with the first about 83 support plate, and both ends are connected with left plate 81 and right plate 82 respectively, the interposition of upper surface
It sets and offers a mounting hole；
Vacuum pump 50 is installed on the left end of the upper surface of the second support plate 84, and perfluoropropane gas steel cylinder 30 is installed on second
The right end of the upper surface of support plate 84；Connecting seat 10 is installed in mounting hole.
That is, by the way that mounting base 80 is arranged, can the various components of the present invention be subjected to integrative installation technology, a side
On the other hand face, also allows for carrying the present invention convenient for the operation present invention in use.
In some examples of the present invention, it is provided with fixed seat 831 in the first support plate 83, is offered in fixed seat 831
Multiple slots are equipped with a vibrator in each slot.In this way, when after second of addition perfluoropropane gas, can open
Vibrator, in order to the mixing of each ingredient of reagent bottle 90.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
Centainly refer to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be any
One or more embodiments or example in can be combined in any suitable manner.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art are not departing from the principle of the present invention and objective
In the case of can make changes, modifications, alterations, and variations to the above described embodiments within the scope of the invention.
Claims (8)
1. a kind of preparation facilities of lipid ultrasonic microbubble contrast agent, which is characterized in that including：
Connecting seat, the connecting seat include connecting plate and multiple tube bodies, evenly spaced on the connecting plate to offer multiple insert
Entrance, the evenly spaced lower surface for being set to the connecting plate of the multiple tube body, upper end respectively with the multiple insert port
It is connected to, is evenly provided with a plurality of graduation mark on outer wall, and offer first interface and second interface；
Multiple seal assemblies, the multiple seal assembly are respectively arranged in the multiple tube body, each seal assembly packet
Include top plate, guide sleeve, bottom plate and ball sealer, the top plate and bottom plate is opposing upper and lower is set in the tube body, and top plate
Between first interface and second interface, bottom plate is located at below second interface, the upper surface of the top plate and a plurality of quarter
The zero graduation line of degree line is flush, and the center of top plate offers a first through hole, and the marginal position of the bottom plate opens up
There are multiple second through-holes, the guide sleeve to be set between the top plate and bottom plate, upper end is connect with the top plate, lower end with
Bottom plate connection, offers multiple third through-holes on outer wall, and the ball sealer passes through the elastic component that is set on the bottom plate
Be installed in the guide sleeve, and when elastic component is not by outer force effect by the sealing top dome as the first through hole,
So as to seal the first through hole；
Perfluoropropane gas steel cylinder, the perfluoropropane gas steel cylinder are connected by multiple first tracheaes with the first interface
It is logical, and one end that each first tracheae closes on the first interface is provided with the first valve；
Multiple piston components, the multiple piston component is drawable respectively to be set in the multiple tube body, for extracting
The gas in perfluoropropane gas steel cylinder is stated, when the piston component moves downwardly to extreme position, lower end stretches to described
Ball sealer described in the interior and downward ejection of first through hole, so as to open the first through hole；
Vacuum pump, the vacuum pump are connected by multiple second tracheaes with second interface, and are faced on each second tracheae
One end of the nearly second interface is provided with the second valve；
Multiple needle bodies, the multiple needle body are connected by hose with the lower end of multiple tube bodies respectively.
2. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 1, which is characterized in that further include that locking is solid
Determine component, the component that is locked includes the first fixed plate, the second fixed plate, transverse slat and locking member；State the first fixed plate and
Second fixed plate or so is oppositely arranged, and the left end vertical connection of the lower end of the first fixed plate and the connecting plate, upper end and company
Fishplate bar is parallel, and the right end vertical connection of the lower end of the second fixed plate and the connecting plate, upper end is parallel with connecting plate, and described first
The upper end of fixed plate and the second fixed plate offers threaded hole；
Offer multiple sets of holes on the transverse slat, the multiple sets of holes and multiple insert ports on the connecting plate phase up and down one by one
It is right, and the multiple piston component is arranged in respectively in the multiple sets of holes；
There are two the locking member settings, and two locking members are threadedly coupled with two threaded holes respectively, and positioned at a left side
Between fixed plate and right fixed plate.
3. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 1, which is characterized in that the piston component
Including piston body and push rod；
The piston body includes piston head and mandril, and the push rod is connected with the upper end of the piston head, for driving the work
Chock plug moves up and down in the tube body, and the mandril is connected with the lower end of the piston head, and the outer diameter of mandril is less than described
The internal diameter of first through hole；
When the push rod drives the piston head to move downwardly to extreme position, the mandril stretches into the first through hole,
And ball sealer described in ejection downwards, so as to open the first through hole.
4. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 3, which is characterized in that multiple insertions
The internal diameter of mouth is adapted with the outer diameter of the push rod, and is provided with sealing ring on the inner wall of each insert port.
5. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 1, which is characterized in that further include installation
Seat, the mounting base includes left plate, right plate, the first support plate and the second support plate；
The lower end of the left plate and right plate is connected with the left and right ends of first support plate respectively, second support plate
It is oppositely arranged up and down with first support plate, and both ends are connected with the left plate and right plate respectively, the centre of upper surface
Position offers a mounting hole；
The vacuum pump is installed on the left end of the upper surface of second support plate, and the perfluoropropane gas steel cylinder is installed on institute
State the right end of the upper surface of the second support plate；The connecting seat is installed in the mounting hole.
6. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 5, which is characterized in that first support
It is provided with a fixed seat on plate, multiple slots are offered in the fixed seat, vibrator is installed in each slot.
7. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 1, which is characterized in that the tube body is by saturating
Bright material is made.
8. the preparation facilities of lipid ultrasonic microbubble contrast agent according to claim 7, which is characterized in that the ball sealer by
Metal or plastic material are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810681911.3A CN108721651A (en) | 2018-06-27 | 2018-06-27 | The preparation facilities of lipid ultrasonic microbubble contrast agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810681911.3A CN108721651A (en) | 2018-06-27 | 2018-06-27 | The preparation facilities of lipid ultrasonic microbubble contrast agent |
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| CN108721651A true CN108721651A (en) | 2018-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810681911.3A Pending CN108721651A (en) | 2018-06-27 | 2018-06-27 | The preparation facilities of lipid ultrasonic microbubble contrast agent |
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| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US20110208128A1 (en) * | 2010-02-24 | 2011-08-25 | Becton, Dickinson And Company | Safety Drug Delivery Connectors |
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| KR101525955B1 (en) * | 2014-12-26 | 2015-06-09 | (주)제이씨하이텍 | Micro-bubble creating device for sonographic vibration tests |
| CN206304588U (en) * | 2016-12-16 | 2017-07-07 | 谢明星 | A kind of preparation facilities of lipid ultrasonic microbubble contrast agent |
| CN209529729U (en) * | 2018-06-27 | 2019-10-25 | 北京大学深圳医院 | The preparation facilities of lipid ultrasonic microbubble contrast agent |
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- 2018-06-27 CN CN201810681911.3A patent/CN108721651A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US20110208128A1 (en) * | 2010-02-24 | 2011-08-25 | Becton, Dickinson And Company | Safety Drug Delivery Connectors |
| CN104189994A (en) * | 2014-09-11 | 2014-12-10 | 常州健瑞宝医疗器械有限公司 | Gas injection valve and puncturing device with same |
| CN204073093U (en) * | 2014-09-11 | 2015-01-07 | 常州健瑞宝医疗器械有限公司 | Gas injection valve and there is its perforator |
| KR101525955B1 (en) * | 2014-12-26 | 2015-06-09 | (주)제이씨하이텍 | Micro-bubble creating device for sonographic vibration tests |
| CN206304588U (en) * | 2016-12-16 | 2017-07-07 | 谢明星 | A kind of preparation facilities of lipid ultrasonic microbubble contrast agent |
| CN209529729U (en) * | 2018-06-27 | 2019-10-25 | 北京大学深圳医院 | The preparation facilities of lipid ultrasonic microbubble contrast agent |
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