CN108693263A - The quantitative analysis method of trace elements sulphur in a kind of sulfur-bearing organic chemicals - Google Patents
The quantitative analysis method of trace elements sulphur in a kind of sulfur-bearing organic chemicals Download PDFInfo
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Abstract
The present invention provides a kind of quantitative analysis methods of trace elements sulphur in sulfur-bearing organic chemicals, this method uses the high performance liquid chromatograph equipped with diode array detector to be analyzed, using eight alkyl silane bonded silica gels as packed column, the external standard standard curve established by standard solution can rapidly and accurately measure the content of elemental sulfur in sample to be tested, measurement result error is small, minimum to be quantitatively limited to 1 × 10-4μ g, repetitive operation is strong, and TIANZHU XINGNAO Capsul is 98.0%~103.5%, can be widely applied in sulfur-bearing organic chemicals preparation process and final product quality control measure trace elements sulphur.
Description
Technical field
The present invention relates to analysis technical field, quantified more particularly to trace elements sulphur in a kind of sulfur-bearing organic chemicals
Analysis method.
Background technology
Control to simple substance sulfur content is the important content in sulfur-bearing organic chemicals production process.For in chemical products
Micro elemental sulfur, the quality in addition to that can influence the product also have a variety of harmfulness.First elemental sulfur can self-corrosion set
It is standby, and the corrosiveness of other sulphur compounds can be reinforced;Secondly, elemental sulfur can poison catalyst;In addition, it can also promote
Into formation other sulphur compounds such as disulphide, polysulfide, mercaptan etc., and elemental sulfur will cause toxic gas to be arranged
It puts, endangers environment.Therefore, fast and accurately elemental sulfur analysis method is developed to realize to containing micro elemental sulfur in product
Content control is of great significance.
Currently, the gas chromatography-mass spectrometry employed in report about the other elemental sulfur detection method of trace level
Carrying out the method for the simple substance sulfur content in oil, not only cost is higher, and be not suitable for it is a wide range of promote, in addition, this method is not suitable for
The detection of elemental sulfur in the organic chemicals that cannot gasify.Therefore, the other list of trace level in sulfur-bearing organic chemicals how is measured
Matter sulphur is a problem to be solved.
Invention content
The present invention provides a kind of quantitative analysis methods of trace elements sulphur in sulfur-bearing organic chemicals to overcome above-mentioned ask
Topic solves the above problems at least partly.
According to an aspect of the invention, there is provided in a kind of sulfur-bearing organic chemicals trace elements sulphur quantitative analysis side
Method is measured using the high performance liquid chromatograph equipped with diode array detector, the method includes:
(1) chromatographic condition is chosen:Use size for the chromatographic column of 250mm column lengths × 4.6mm internal diameters;With eight alkyl silane keys
Conjunction silica gel is packed column;Mobile phase is the mixed liquor of the acetonitrile that volume ratio is 50~90: 10~50 and water;In the mobile phase
Add the acetic acid that volume is mobile phase 0.2%~0.5%;Detection wavelength is 220nm~300nm;Column temperature is 25~40 DEG C;It is described
The speed of mobile phase is 0.8~1.2mL/min;Sample injection volume is 5~20 μ L;
(2) preparing standard solution:The standard sample for weighing elemental sulfur is configured to 0.1mg/L~20mg/ with flowing phased soln
The series of standards solution of L;
(3) external standard standard curve is established:According to the chromatographic condition in step (1), by the standard solution in step (2) according to
Sample introduction, the concentration that elemental sulfur is corresponded to the peak area of elemental sulfur draw standard curve to the sequence of concentration from low to high successively;
(4) sample to be tested is weighed:It is prepared with toluene dissolving and obtains solution to be measured, sample introduction obtains containing in the solution to be measured
The peak area of some elemental sulfurs calculates the content of sulphur in the sample to be tested according to standard curve.
Optionally, the stationary phase grain size filled in the chromatographic column is 5 μm or 10 μm.
Optionally, the mobile phase is the mixed liquor of acetonitrile and water that volume ratio is 80: 20.
Optionally, the acetic acid that volume is mobile phase 0.2% is added in the mobile phase.
Optionally, the Detection wavelength is 280nm.
Optionally, the column temperature is 30 DEG C.
Optionally, the speed of the mobile phase is 1.0mL/min.
Optionally, the solvent of sample dissolution used is toluene or dimethylbenzene.
What the present invention used analyzes trace elements sulphur using high performance liquid chromatography, the advantage is that:
One, the utilization high performance liquid chromatography that the present invention uses combines diode array detector, selects C8 chromatographic columns,
Using the acid mixed solution of acetonitrile and water as mobile phase, by control column temperature, flow velocity and Detection wavelength, external standard standard curve is established,
The content of trace elements sulphur can accurately be measured.
Two, the present invention uses high performance liquid chromatography quantitative approach, and measurement result error is small, and repetitive operation is strong, adds back
Yield is 98.0%~103.5%;
Three, the present invention uses high performance liquid chromatography quantitative approach, easy to operate, takes shorter, suitable popularity use.
Above description is only the general introduction of technical solution of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, and in order to allow above and other objects of the present invention, feature and advantage can
It is clearer and more comprehensible, below the special specific implementation mode for lifting the present invention.
According to the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will be brighter
The above and other objects, advantages and features of the present invention.
Description of the drawings
By reading the detailed description of hereafter preferred embodiment, various other advantages and benefit are common for this field
Technical staff will become clear.Attached drawing only for the purpose of illustrating preferred embodiments, and is not considered as to the present invention
Limitation.And throughout the drawings, the same reference numbers will be used to refer to the same parts.In the accompanying drawings:
Fig. 1 is the chromatography schematic diagram of standard sample according to the ... of the embodiment of the present invention;
Fig. 2 is standard curve schematic diagram according to an embodiment of the invention;
Fig. 3 is standard curve schematic diagram in accordance with another embodiment of the present invention.
Specific implementation mode
The exemplary embodiment of the disclosure is more fully described below with reference to accompanying drawings.Although showing the disclosure in attached drawing
Exemplary embodiment, it being understood, however, that may be realized in various forms the disclosure without should be by embodiments set forth here
It is limited.On the contrary, these embodiments are provided to facilitate a more thoroughly understanding of the present invention, and can be by the scope of the present disclosure
Completely it is communicated to those skilled in the art.
The present invention provides a kind of quantitative analysis methods of trace elements sulphur in sulfur-bearing organic chemicals, using equipped with two poles
The high performance liquid chromatograph of pipe array detector is measured, and this method includes:
Step S1 chooses chromatographic condition:The size of chromatographic column used in high performance liquid chromatograph is 250mm column lengths × 4.6mm
Internal diameter, the eight alkyl silane bonded silica gels that filling grain size is 5 μm;Mobile phase be volume ratio be 50~90: 10~50 acetonitrile and
The mixed liquor of water;The acetic acid that volume is mobile phase 0.2%~0.5% is added in mobile phase;Detection wavelength be 220nm~
300nm;Column temperature is 25~40 DEG C;The speed of mobile phase is 0.8~1.2mL/min;Sample injection volume is 5~20 μ L;
Step S2, preparing standard solution:The standard sample for weighing elemental sulfur, with flowing phased soln be configured to 0.1mg/L~
The series of standards solution of 20mg/L;
Step S3 establishes external standard standard curve:It is according to the chromatographic condition in above-mentioned steps S1, the standard in step S2 is molten
Liquid is according to concentration sequence from low to high successively sample introduction, and the concentration of elemental sulfur is corresponded to the peak area of elemental sulfur, and to draw standard bent
Line;
Step S4, weighs sample to be tested:It is prepared with toluene dissolving and obtains solution to be measured, sample introduction obtains containing in solution to be measured
The peak area of some elemental sulfurs calculates the content of elemental sulfur in sample to be tested according to standard curve.
The quantitative analysis method of trace elements sulphur, this method in the sulfur-bearing organic chemicals provided according to embodiments of the present invention
It is analyzed using the high performance liquid chromatograph equipped with diode array detector, is filling with eight alkyl silane bonded silica gels
Column, the external standard standard curve established by standard solution can rapidly and accurately measure the content of sulphur simple substance in sample to be tested, measure
Resultant error is small, minimum to be quantitatively limited to 1 × 10-4μ g, repetitive operation is strong, and TIANZHU XINGNAO Capsul is 98.0%~103.5%, can be with
It is widely used in measuring trace elements sulphur in sulfur-bearing organic chemicals preparation process and final product quality control.Wherein, in chromatographic column
The grain size of middle filled eight alkyl silane bonded silica gel of stationary phase is 5 μm or 10 μm, preferably 5 μm, certainly can also be according to reality
Border test case uses the stationary phase of other particle sizes, the present invention not to limit.
In embodiments of the present invention, the standard sample of elemental sulfur is the crystal powder that purity is not less than 99.0%;Wait for test sample
Product are the solid powder or solution for the organic chemicals for adhering to sulphur.
Further, in the chromatographic condition selected by above-mentioned steps S1, mobile phase is the acetonitrile that volume ratio is preferably 80: 20
With the mixed liquor of water;The acetic acid that volume is mobile phase 0.2% is preferably added in mobile phase;Detection wavelength is 280nm;Column temperature is
30℃;It is preferably 1.0mL/min to flow phase velocity;The solvent of sample dissolution used is toluene or dimethylbenzene.Certainly, above-mentioned colors
Spectral condition can be adjusted according to the difference of sample to be tested, and the present invention does not limit.
Above-described embodiment is described in detail below by several preferred embodiments, equipment employed in each embodiment and
Reagent is as follows:
Instrument:Shimadzu LC-20AT PDA;
Chromatographic column:Agilent Zorbax C8, (250 × 4.6mm, 5 μm);
Acetonitrile:Chromatographically pure;
Ultra-pure water;
Acetic acid:Chromatographically pure;
Toluene:It analyzes pure;
Dimethylbenzene:It analyzes pure.
Embodiment one:Dibenzothiophenes (CAS#:132-65-0) in product trace elements sulfur content measurement
1. high-efficient liquid phase chromatogram condition
Mobile phase is prepared:Learn from else's experience the acetonitrile 800ml after 0.45 μm of organic system membrane filtration and through 0.45 μm of water system filter membrane mistake
Ultra-pure water 200ml after filter, mixing, then the acetic acid addition for pipetting 2ml is wherein, after mixing, is deaerated partly with ultrasonic cleaning machine
Hour, it places to room temperature;
Flow velocity:1.0mL/min;
Column temperature:30℃;
Detection wavelength:280nm;
Sample injection volume:10μL.
2. preparing the elemental sulfur standard solution of various concentration
1. accurately weighing the elemental sulfur standard items of 62.5mg in 250mL volumetric flasks, dissolved with toluene, after ultrasonic 10min
With toluene constant volume;
2. pipette respectively 1. described in standard solution 0.1mL, 0.2mL, 0.5mL, 1m, 2ml, 5ml in 100mL volumetric flasks
In, with acetonitrile constant volume, the respectively elemental sulfur of 0.25mg/L, 0.5mg/L, 1.25mg/L, 2.5mg/L, 5mg/L, 12.5mg/L
Titer;
Fig. 1 shows the chromatography schematic diagram of elemental sulfur standard solution, in Fig. 1, the retention time tR=of chromatographic peak
8.510min is the peak of elemental sulfur;
3. according to the chromatographic condition in step 1, each titer of elemental sulfur is analyzed by the order of concentration from low to high,
Every part of standard solution measures 3 times, is averaged as a result, using the peak area of elemental sulfur as ordinate, the mass concentration of elemental sulfur is cross
Coordinate, drafting standard curve are y=31075x-873.1, as shown in Figure 2;The range of linearity is 0.25mg/L~12.5mg/L, line
Property coefficient R 2=0.999.
Table 1
| Concentration (mg/L) | Peak area |
| 0.25 | 7690 |
| 0.5 | 15674 |
| 1.25 | 37690 |
| 2.5 | 73456 |
| 5 | 156490 |
| 12.5 | 387416 |
4. weighing sample to be tested~60mg (exact value 0.0001g) in 100mL volumetric flasks, the dissolving of 70ml toluene is added,
Acetonitrile constant volume is used after ultrasonic 10min, filters to take after clear liquid that sample introduction is analyzed, measures the peak area of elemental sulfur, combined standard curve, meter
The mass concentration for calculating elemental sulfur in the solution of sample to be tested is 0.62mg/L, i.e., the mass fraction of elemental sulfur is 1.03 μ g/g.
5. weighing sample to be tested~60mg (exact value 0.0001g) in 100mL volumetric flasks, the 2. middle institute of removing step 2
The simple substance standard sulfate solution 10ml of 5mg/L is stated in wherein, is dissolved with 70ml toluene, ultrasonic 10min, then with being filtered after acetonitrile constant volume,
Taking clear liquid, sample introduction is analyzed, measures the peak area of elemental sulfur, and combined standard curve calculates a concentration of after elemental sulfur addition
1.11mg/L, according to formula:
It is 98.0% to calculate TIANZHU XINGNAO Capsul.
Embodiment two:Benzothiazole (CAS#:95-16-9) in product trace elements sulphur measurement
1. high-efficient liquid phase chromatogram condition:
Mobile phase is prepared:Learn from else's experience the acetonitrile 700ml after 0.45 μm of organic system membrane filtration and through 0.45 μm of water system filter membrane mistake
Ultra-pure water 300ml after filter, mixing, then the acetic acid addition for pipetting 2ml is wherein, after mixing, is deaerated partly with ultrasonic cleaning machine
Hour, it places to room temperature;
Flow velocity:1.2mL/min;
Column temperature:35℃;
Detection wavelength:280nm;
Sample injection volume:20μL.
2. preparing the elemental sulfur standard solution of various concentration:
1. the elemental sulfur standard items of 62.5mg are accurately weighed in 250mL volumetric flasks, with xylene soluble, ultrasonic 10min
Dimethylbenzene constant volume afterwards;
2. pipetting 1. Plays solution 0.1mL, 0.2mL, 0.5mL, 1m, 2ml, 5ml respectively to use in 100mL volumetric flasks
Acetonitrile constant volume, respectively the elemental sulfur standard of 0.25mg/L, 0.5mg/L, 1.25mg/L, 2.5mg/L, 5mg/L, 12.5mg/L
Liquid;
3. according to the chromatographic condition in step 1, each titer of elemental sulfur is analyzed by the order of concentration from low to high,
Every part of standard solution measures 3 times, is averaged as a result, using the peak area of elemental sulfur as ordinate, the mass concentration of elemental sulfur is cross
Coordinate, drafting standard curve are y=62175x-1835, as shown in Figure 3;The range of linearity is 0.25mg/L~12.5mg/L, linearly
Coefficient R 2=0.999.
Table 2
| Concentration (mg/L) | Peak area |
| 0.25 | 15180 |
| 0.5 | 31342 |
| 1.25 | 75389 |
| 2.5 | 146811 |
| 5 | 313089 |
| 12.5 | 775030 |
4. weighing sample to be tested~70mg (exact value 0.0001g) in 100mL volumetric flasks, it is molten that 70ml dimethylbenzene is added
Solution uses acetonitrile constant volume after ultrasonic 10min, and filtering to take clear liquid, sample introduction is analyzed, measures the peak area of elemental sulfur, combined standard curve,
The mass concentration for calculating elemental sulfur in the solution of sample to be tested is 0.83mg/L, i.e., the mass fraction of elemental sulfur is 1.18 μ g/
g。
5. weighing sample to be tested~70mg (exact value 0.0001g) in 100mL volumetric flasks, the 2. middle institute of removing step 2
The simple substance standard sulfate solution 20ml of 5mg/L is stated in wherein, with 70ml xylene solubles, uses acetonitrile constant volume after ultrasonic 10min, filter to take
Sample introduction is analyzed for clear liquid, measures the peak area of elemental sulfur, combined standard curve, total mass concentration is after calculating the addition of elemental sulfur
1.835mg/L according to formula:
TIANZHU XINGNAO Capsul is 100.5%.
Finally it should be noted that:The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that:At this
It, still can be with technical scheme described in the above embodiments is modified or right within the spirit and principle of invention
Which part or all technical features carry out equivalent replacement;And these modifications or replacements, do not make corresponding technical solution de-
From protection scope of the present invention.
Claims (8)
1. the quantitative analysis method of trace elements sulphur in a kind of sulfur-bearing organic chemicals, using equipped with diode array detector
High performance liquid chromatograph is measured, the method includes:
(1) chromatographic condition is chosen:Use size for the chromatographic column of 250mm column lengths × 4.6mm internal diameters;With eight alkyl silane bonded silicas
Glue is packed column;Mobile phase is that volume ratio is 50~90:10~50 acetonitrile and the mixed liquor of water;It is added in the mobile phase
Volume is the acetic acid of mobile phase 0.2%~0.5%;Detection wavelength is 220nm~300nm;Column temperature is 25~40 DEG C;The flowing
The speed of phase is 0.8~1.2mL/min;Sample injection volume is 5~20 μ L;
(2) preparing standard solution:The standard sample for weighing elemental sulfur is configured to 0.1mg/L~20mg/L's with flowing phased soln
Series of standards solution;
(3) external standard standard curve is established:According to the chromatographic condition in step (1), by the standard solution in step (2) according to concentration
Sample introduction, the concentration that elemental sulfur is corresponded to the peak area of elemental sulfur draw standard curve to sequence from low to high successively;
(4) sample to be tested is weighed:It is prepared with toluene dissolving and obtains solution to be measured, sample introduction obtains containing in the solution to be measured
The peak area of elemental sulfur calculates the content of elemental sulfur in the sample to be tested according to standard curve.
2. according to the method described in claim 1, it is characterized in that, the stationary phase grain size filled in the chromatographic column is 5 μm
Or 10 μm.
3. according to the method described in claim 1, it is characterized in that, it is 80 that the mobile phase, which is volume ratio,:20 acetonitrile and water
Mixed liquor.
4. according to the method described in claim 1, it is characterized in that, the volume of the acetic acid is the mobile phase volume
0.2%.
5. according to the method described in claim 1, it is characterized in that, the Detection wavelength is 280nm.
6. according to the method described in claim 1, it is characterized in that, the column temperature is 30 DEG C.
7. according to the method described in claim 1, it is characterized in that, the speed of the mobile phase is 1.0mL/min.
8. according to the method described in claim 1, it is characterized in that, the solvent of sample dissolution used is toluene or dimethylbenzene.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116086931A (en) * | 2022-12-12 | 2023-05-09 | 浙江大学 | Soil hexavalent chromium determination method for eliminating interference of chalcogenide reducing agent |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999058951A1 (en) * | 1998-05-12 | 1999-11-18 | Exxon Research And Engineering Company | Method for analyzing total reactive sulfur |
| CN102288713A (en) * | 2011-07-29 | 2011-12-21 | 江苏省中医药研究院 | Authentication method for rapidly judging whether white paeony root is fumigated by sulfur or not |
| CN102590415A (en) * | 2012-01-19 | 2012-07-18 | 江苏丰山集团有限公司 | Method for determining content of sulfur impurities in intermediate 2,6-dichloro quinoxaline of quizalofop-p-ethyl technical material |
| CN106033074A (en) * | 2015-03-09 | 2016-10-19 | 中国石油化工股份有限公司 | Analysis method of dibenzothiophene and thiophanthrene |
| CN107607652A (en) * | 2017-10-18 | 2018-01-19 | 北京理工大学 | A kind of method for determining flower of JINHUAKUI sulfur content |
-
2018
- 2018-04-27 CN CN201810398170.8A patent/CN108693263A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999058951A1 (en) * | 1998-05-12 | 1999-11-18 | Exxon Research And Engineering Company | Method for analyzing total reactive sulfur |
| CN102288713A (en) * | 2011-07-29 | 2011-12-21 | 江苏省中医药研究院 | Authentication method for rapidly judging whether white paeony root is fumigated by sulfur or not |
| CN102590415A (en) * | 2012-01-19 | 2012-07-18 | 江苏丰山集团有限公司 | Method for determining content of sulfur impurities in intermediate 2,6-dichloro quinoxaline of quizalofop-p-ethyl technical material |
| CN106033074A (en) * | 2015-03-09 | 2016-10-19 | 中国石油化工股份有限公司 | Analysis method of dibenzothiophene and thiophanthrene |
| CN107607652A (en) * | 2017-10-18 | 2018-01-19 | 北京理工大学 | A kind of method for determining flower of JINHUAKUI sulfur content |
Non-Patent Citations (4)
| Title |
|---|
| BUSHWAY, RJ 等: "LIQUID-CHROMATOGRAPHIC METHOD FOR ANALYSIS OF ELEMENTAL SULFUR IN PESTICIDE FORMULATIONS", 《JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS》 * |
| DONG CHEN 等: "Determination of Elemental Sulfur in the Presence of Anaerobic Sediments by Extraction Procedure Using High-Performance Liquid Chromatography", 《WATER AIR SOIL POLLUT》 * |
| 吴艳青 等: "硅烷偶联剂Si-69中单质硫与化合态硫的液相色谱分析研究", 《杭州师范大学学报（自然科学版）》 * |
| 施继琴: "高效液相色谱法测定二硫化铁中硫含量研究", 《化学工程与装备》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116086931A (en) * | 2022-12-12 | 2023-05-09 | 浙江大学 | Soil hexavalent chromium determination method for eliminating interference of chalcogenide reducing agent |
| CN116086931B (en) * | 2022-12-12 | 2023-08-11 | 浙江大学 | Soil hexavalent chromium determination method for eliminating interference of chalcogenide reducing agent |
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