The object of the present invention is to provide a kind of multiple arteries and veins Chinese patent medicine of hemostasis and production method thereof that is used for the treatment of syncope (hemorrhagic shock), this medical instrument has the voltage stabilizing of boosting to strengthen the function of myocardium power, has the curative effect of treatment syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage.This medicine taking convenience is not subjected to the restriction of environmental condition, can in time treat syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage in the environment of treatment inclement condition.
Feature of the present invention is solid medical material Colla Corii Asini, Radix Aconiti Lateralis Preparata Rhizoma Chuanxiong, the following column weight amount of Radix Et Rhizoma Rhei percentage formula:
Colla Corii Asini 50-35% Radix Aconiti Lateralis Preparata 25-15%
Rhizoma Chuanxiong 25-20% Radix Et Rhizoma Rhei 15-8%
Its preparation production method is as follows:
A, extraction volatile oil: get Rhizoma Chuanxiong and add water 3-6 doubly, soak in the rearmounted volatile oil extractor, heat and extracted volatile oil in 6-8 hour to most, collection volatile oil, the water liquid after the distillation, medicinal residues are placed respectively.
B, decocting: get Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata and add water 12-15 doubly, decocts 2.5 hours after-filtration and go out medicinal liquid, in Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata medicinal residues, add the row decoction 2 hours again of Rhizoma Chuanxiong medicinal residues then, decoct for the third time after leaching medicinal liquid.
C, precipitate with ethanol: the medicinal liquid that decocts for three times mixed being concentrated into a certain amount of (every milliliter of suitable crude drug in whole 1.0-1.5g of medicinal liquid) relative density 1.10-1.20(80 ℃ with water liquid after the Rhizoma Chuanxiong distillation) precipitate with ethanol: making medicinal liquid contain that alcohol measures is 60-70%, and 4-10 ℃ left standstill Cryoprecipitation 24-72 hour.Reclaim ethanol then, medicinal liquid is concentrated into relative density 1.15-1.30.
D, glue liquid: get Colla Corii Asini and add water-solubleization, filter, be concentrated into relative density 1.10-1.15.
E, mixing: glue, Rhizoma Chuanxiong volatile oil, spissated decocting liquid are mixed into the multiple arteries and veins medicinal liquid of hemostasis, its relative density 1.05-1.30.
The admixing medical solutions that above method makes can be made mixture, syrup, soft extract, granule, capsule, electuary, tablet etc. through conventional method processing.
The present invention system is Colla Corii Asini 50-35% by percentage by weight.Radix Aconiti Lateralis Preparata 25-15%, Rhizoma Chuanxiong 25-20%, the Chinese crude drug of Radix Et Rhizoma Rhei 15-8%, through the Chinese patent medicine that extraction is processed into, its composition should be based on Colla Corii Asini, and contains the Main Ingredients and Appearance of Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei.
The Chinese patent medicine that the present invention makes has nourishing YIN and benefiting blood, the antiabortive effect of lung moistening based on hematonic Colla Corii Asini, Colla Corii Asini; The extremely strong dibasic acid esters Aconitum carmichjaelii Debx. of contained toxicity is salty in the Radix Aconiti Lateralis Preparata crude drug in whole, in the processing concocting process, be hydrolyzed to benzoyl aconine and aconine, the toxicity of this type of composition is little, but the strengthening heart and boosting pressure effect remains unchanged, the traditional Chinese medical science emphasizes that Radix Aconiti Lateralis Preparata need fry in shallow oil steaming of a specified duration for a long time, so the Radix Aconiti Lateralis Preparata decocting time was greater than 2 hours in this product method for making, the known effective constituent that mainly contains of Rhizoma Chuanxiong is ligustrazine, volatile oil, ferulic acid etc., Rhizoma Chuanxiong extract and biological saltyly can expand coronary vasodilator, increase coronary blood flow, improve the myocardial ischemia situation, its lactone composition has spasmolysis preferably.The Main Ingredients and Appearance of Radix Et Rhizoma Rhei is a Radix Et Rhizoma Rhei Herba Alii fistulosi quinone, and clinical practice has at present exceeded traditional discharge function, makes in this product with a small amount of cold and cool Radix Et Rhizoma Rhei, gets the power of its blood circulation and channel invigorating detoxifcation.Destroy it with long-time decoction in this technology and rush down and active ingredient chrysophanic acid and analog thereof, and play blood circulation and removing stasis, the feeling pulse effect of stimulating the menstrual flow.Manufactured goods of the present invention adopt the said medicine compatibility, have boost, the effect of voltage stabilizing, enhancing myocardial function, microcirculation improvement, have the multiple arteries and veins of definite YIN nourishing, recuperating depleted YANG and rescuing the patient from collapse, removing stasis to stop bleeding effect, have the curative effect of definite treatment syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage, and can treat department of obstetrics and gynecology massive hemorrhage illness effectively.Adopt this processing step can reduce the loss on heating of volatile oil and float on the medicinal liquid top layer.
Prove that through animal experimental observation this medical instrument has the animal dis of raising motility rate, promote blood pressure to go up and stable, enhancing myocardium shrinkage function, increase painstaking effort output, microcirculation improvement effect, and proof to take acute toxicity in a large number very little, take no toxicity for a long time, drug safety; Clinical practice shows, this medicine is to total obvious effective rate 77.19% of syncope (hemorrhagic shock) treatment, this product has definite hemostatic healing efficacy to cause of disease haematemesis, the melena (upper gastrointestinal hemorrhage) that causes weakness of QI blood prostration disease (hemorrhagic shock), its total obvious effective rate is 95.61%, the precedent for the treatment of syncope (hemorrhagic shock) with oral Chinese patent medicine has been started in succeeding in developing of this medicine, and a kind of Chinese patent medicine of safe and effective, taking convenience also is provided for the treatment upper gastrointestinal hemorrhage.This medicine can in time be treated to faint in the environment of inclement condition and be taken off disease and upper gastrointestinal hemorrhage.