CN1086726A - Multiple arteries and veins Chinese patent medicine of hemostasis and production method thereof - Google Patents
Multiple arteries and veins Chinese patent medicine of hemostasis and production method thereof Download PDFInfo
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- CN1086726A CN1086726A CN93109769A CN93109769A CN1086726A CN 1086726 A CN1086726 A CN 1086726A CN 93109769 A CN93109769 A CN 93109769A CN 93109769 A CN93109769 A CN 93109769A CN 1086726 A CN1086726 A CN 1086726A
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Abstract
Multiple arteries and veins Chinese patent medicine of hemostasis and production method thereof belong to the Chinese medicine preparation, and this medicine is by raw material of Chinese medicine Colla Corii Asini, Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, through volatile oil extract, decoct, concentrate, precipitate with ethanol, mixing and make.This preparation method can reduce the volatile oil loss of effective components, and can with the medicinal liquid mix homogeneously, destroy the toxic and side effects of medical material.This product is provided convenience to treatment hemorrhagic shock under mal-condition, and have the voltage stabilizing of boosting, strengthen myocardial function, the effect of microcirculation improvement, to the treatment hemorrhagic shock, upper gastrointestinal hemorrhage has definite curative effect.The clinical practice total effective rate is 77.19%.
Description
The present invention relates to contain the raw material that do not indicate component or the pharmaceutical product of its product, particularly a kind of is the Chinese patent medicine goods of raw material with the Chinese crude drug.
Treatment to syncope (hemorrhagic shock) mainly is the transfusion replenishment of blood content at present, generally only limits to carry out in the commune hospital in hospital, and in the mountain area away from hospital, rural area or battlefield are because of inclement condition then is difficult to transfuse blood, fluid-supplement therapy.Syncope (hemorrhagic shock) is a kind of anxious severe disease disease, as can not in time rescuing, tends to delay treatment.
The object of the present invention is to provide a kind of multiple arteries and veins Chinese patent medicine of hemostasis and production method thereof that is used for the treatment of syncope (hemorrhagic shock), this medical instrument has the voltage stabilizing of boosting to strengthen the function of myocardium power, has the curative effect of treatment syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage.This medicine taking convenience is not subjected to the restriction of environmental condition, can in time treat syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage in the environment of treatment inclement condition.
Feature of the present invention is solid medical material Colla Corii Asini, Radix Aconiti Lateralis Preparata Rhizoma Chuanxiong, the following column weight amount of Radix Et Rhizoma Rhei percentage formula:
Colla Corii Asini 50-35% Radix Aconiti Lateralis Preparata 25-15%
Rhizoma Chuanxiong 25-20% Radix Et Rhizoma Rhei 15-8%
Its preparation production method is as follows:
A, extraction volatile oil: get Rhizoma Chuanxiong and add water 3-6 doubly, soak in the rearmounted volatile oil extractor, heat and extracted volatile oil in 6-8 hour to most, collection volatile oil, the water liquid after the distillation, medicinal residues are placed respectively.
B, decocting: get Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata and add water 12-15 doubly, decocts 2.5 hours after-filtration and go out medicinal liquid, in Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata medicinal residues, add the row decoction 2 hours again of Rhizoma Chuanxiong medicinal residues then, decoct for the third time after leaching medicinal liquid.
C, precipitate with ethanol: the medicinal liquid that decocts for three times mixed being concentrated into a certain amount of (every milliliter of suitable crude drug in whole 1.0-1.5g of medicinal liquid) relative density 1.10-1.20(80 ℃ with water liquid after the Rhizoma Chuanxiong distillation) precipitate with ethanol: making medicinal liquid contain that alcohol measures is 60-70%, and 4-10 ℃ left standstill Cryoprecipitation 24-72 hour.Reclaim ethanol then, medicinal liquid is concentrated into relative density 1.15-1.30.
D, glue liquid: get Colla Corii Asini and add water-solubleization, filter, be concentrated into relative density 1.10-1.15.
E, mixing: glue, Rhizoma Chuanxiong volatile oil, spissated decocting liquid are mixed into the multiple arteries and veins medicinal liquid of hemostasis, its relative density 1.05-1.30.
The admixing medical solutions that above method makes can be made mixture, syrup, soft extract, granule, capsule, electuary, tablet etc. through conventional method processing.
The present invention system is Colla Corii Asini 50-35% by percentage by weight.Radix Aconiti Lateralis Preparata 25-15%, Rhizoma Chuanxiong 25-20%, the Chinese crude drug of Radix Et Rhizoma Rhei 15-8%, through the Chinese patent medicine that extraction is processed into, its composition should be based on Colla Corii Asini, and contains the Main Ingredients and Appearance of Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei.
The Chinese patent medicine that the present invention makes has nourishing YIN and benefiting blood, the antiabortive effect of lung moistening based on hematonic Colla Corii Asini, Colla Corii Asini; The extremely strong dibasic acid esters Aconitum carmichjaelii Debx. of contained toxicity is salty in the Radix Aconiti Lateralis Preparata crude drug in whole, in the processing concocting process, be hydrolyzed to benzoyl aconine and aconine, the toxicity of this type of composition is little, but the strengthening heart and boosting pressure effect remains unchanged, the traditional Chinese medical science emphasizes that Radix Aconiti Lateralis Preparata need fry in shallow oil steaming of a specified duration for a long time, so the Radix Aconiti Lateralis Preparata decocting time was greater than 2 hours in this product method for making, the known effective constituent that mainly contains of Rhizoma Chuanxiong is ligustrazine, volatile oil, ferulic acid etc., Rhizoma Chuanxiong extract and biological saltyly can expand coronary vasodilator, increase coronary blood flow, improve the myocardial ischemia situation, its lactone composition has spasmolysis preferably.The Main Ingredients and Appearance of Radix Et Rhizoma Rhei is a Radix Et Rhizoma Rhei Herba Alii fistulosi quinone, and clinical practice has at present exceeded traditional discharge function, makes in this product with a small amount of cold and cool Radix Et Rhizoma Rhei, gets the power of its blood circulation and channel invigorating detoxifcation.Destroy it with long-time decoction in this technology and rush down and active ingredient chrysophanic acid and analog thereof, and play blood circulation and removing stasis, the feeling pulse effect of stimulating the menstrual flow.Manufactured goods of the present invention adopt the said medicine compatibility, have boost, the effect of voltage stabilizing, enhancing myocardial function, microcirculation improvement, have the multiple arteries and veins of definite YIN nourishing, recuperating depleted YANG and rescuing the patient from collapse, removing stasis to stop bleeding effect, have the curative effect of definite treatment syncope (hemorrhagic shock) and treatment upper gastrointestinal hemorrhage, and can treat department of obstetrics and gynecology massive hemorrhage illness effectively.Adopt this processing step can reduce the loss on heating of volatile oil and float on the medicinal liquid top layer.
Prove that through animal experimental observation this medical instrument has the animal dis of raising motility rate, promote blood pressure to go up and stable, enhancing myocardium shrinkage function, increase painstaking effort output, microcirculation improvement effect, and proof to take acute toxicity in a large number very little, take no toxicity for a long time, drug safety; Clinical practice shows, this medicine is to total obvious effective rate 77.19% of syncope (hemorrhagic shock) treatment, this product has definite hemostatic healing efficacy to cause of disease haematemesis, the melena (upper gastrointestinal hemorrhage) that causes weakness of QI blood prostration disease (hemorrhagic shock), its total obvious effective rate is 95.61%, the precedent for the treatment of syncope (hemorrhagic shock) with oral Chinese patent medicine has been started in succeeding in developing of this medicine, and a kind of Chinese patent medicine of safe and effective, taking convenience also is provided for the treatment upper gastrointestinal hemorrhage.This medicine can in time be treated to faint in the environment of inclement condition and be taken off disease and upper gastrointestinal hemorrhage.
The optimum weight percentage formula of Shi Yonging is aborning:
Colla Corii Asini 45.45, Radix Aconiti Lateralis Preparata 20.45, Rhizoma Chuanxiong 22.73, Radix Et Rhizoma Rhei 11.36.
To can make mixture or syrup by the sucrose that the multiple arteries and veins medicinal liquid of the hemostasis that preceding method makes adds 10-70%, and further concentrate and can be made into soft extract; To stop blooding and answer arteries and veins medicinal liquid centrifugal spray drying method, inlet temperature 150-250 ℃, rotating speed 7000-20000 rev/min, obtain dried particles, directly pack is granule, filling is capsule in capsule; The multiple arteries and veins medicinal liquid that will stop blooding adds Icing Sugar, dextrin, and proportioning is 1: 2.5-3.5: 1-2 makes electuary; The multiple arteries and veins medicinal liquid adding 2-3 that will stop blooding measure dextrin, 1-2 and doubly measure starch, and 3-4 doubly measures the magnesium stearate of cane sugar powder and 0.5-2% and makes tablet.
Claims (8)
1, the multiple arteries and veins Chinese patent medicine of hemostasis is characterized in that used medical material is by following percentage by weight prescription: Colla Corii Asini 50-35%.Attached 25-15%, Rhizoma Chuanxiong 25-20%, the Chinese crude drug of Radix Et Rhizoma Rhei 15-8%, through extraction be processed into for patent medicine, its composition should be based on Colla Corii Asini, and contains the Main Ingredients and Appearance of Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei.
2, the preparation method of the multiple arteries and veins Chinese patent medicine of hemostasis according to claim 1 is characterized in that this method realizes as follows:
A, extraction volatile oil: get Rhizoma Chuanxiong and add water 3-6 doubly, soak in the rearmounted volatile oil extractor, heat and extracted volatile oil in 6-8 hour to most, collection volatile oil, the water liquid after the distillation, medicinal residues are placed respectively.
B, decocting: get Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata and add water 12-15 doubly, decocts 2.5 hours after-filtration and go out medicinal liquid, in Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata medicinal residues, add the row decoction 2 hours again of Rhizoma Chuanxiong medicinal residues then, decoct for the third time after leaching medicinal liquid.
C, precipitate with ethanol: the medicinal liquid that decocts for three times mixed being concentrated into a certain amount of (every milliliter of suitable crude drug in whole 1.0-1.5g of medicinal liquid) relative density 1.10-1.20(80 ℃ with water liquid after the Rhizoma Chuanxiong distillation) precipitate with ethanol: making medicinal liquid contain that alcohol measures is 60-70%, and 4-10 ℃ left standstill Cryoprecipitation 24-72 hour.Reclaim ethanol then, medicinal liquid is concentrated into relative density 1.15-1.30.
D, glue liquid: get Colla Corii Asini and add water-solubleization, filter, be concentrated into relative density 1.10-1.15.
E, mixing: glue, Rhizoma Chuanxiong volatile oil, spissated decocting liquid are mixed into the multiple arteries and veins medicinal liquid of hemostasis, its relative density 1.05-1.30.
The admixing medical solutions that above method makes can be made various Chinese patent medicine dosage forms through conventional method processing.
3, the multiple arteries and veins Chinese patent medicine of hemostasis as claimed in claim 1, it is characterized in that used medical material by weight percentage prescription be: Colla Corii Asini 45.45, Radix Aconiti Lateralis Preparata 20.45, Rhizoma Chuanxiong 22.73, Radix Et Rhizoma Rhei 11.36.
4, as claim 1 or the multiple arteries and veins Chinese patent medicine of 3 described hemostasis, it is characterized in that this medicine can be applicable to treat illness such as hemorrhagic shock, upper gastrointestinal hemorrhage and department of obstetrics and gynecology massive hemorrhage.
5, by claim 1, the multiple arteries and veins Chinese patent medicine of 2 described hemostasis and production method, it is characterized in that adding in the multiple arteries and veins medicinal liquid of the mixed hemostasis of Colla Corii Asini and medicinal liquid the sucrose of 10-70%, can make mixture or syrup or soft extract.
6, by claim 1, the multiple arteries and veins Chinese patent medicine of 2 described hemostasis and production method, the multiple arteries and veins medicinal liquid that it is characterized in that stopping blooding, available centrifugal spray drying method is made granule or capsule.During its centrifugal spray drying inlet temperature 150-250 ℃, rotating speed 7000-20000 rev/min.
7, by multiple arteries and veins Chinese patent medicine of claim 1,2 described hemostasis and production method, the multiple arteries and veins medicinal liquid that it is characterized in that stopping blooding can add sucrose, dextrin is made electuary.
8, by claim 1, the multiple arteries and veins Chinese patent medicine of 2 described hemostasis and production method, the multiple arteries and veins medicinal liquid that it is characterized in that stopping blooding can add excipient such as starch, dextrin sucrose, magnesium stearate and make tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93109769A CN1050047C (en) | 1993-08-16 | 1993-08-16 | Ready made traditional Chinese medicine for arresting bleeding and pulse restoring and its producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93109769A CN1050047C (en) | 1993-08-16 | 1993-08-16 | Ready made traditional Chinese medicine for arresting bleeding and pulse restoring and its producing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1086726A true CN1086726A (en) | 1994-05-18 |
| CN1050047C CN1050047C (en) | 2000-03-08 |
Family
ID=4987775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93109769A Expired - Lifetime CN1050047C (en) | 1993-08-16 | 1993-08-16 | Ready made traditional Chinese medicine for arresting bleeding and pulse restoring and its producing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1050047C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063070C (en) * | 1997-06-03 | 2001-03-14 | 宋世昌 | Medicine for raising blood pressure and its preparation |
-
1993
- 1993-08-16 CN CN93109769A patent/CN1050047C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063070C (en) * | 1997-06-03 | 2001-03-14 | 宋世昌 | Medicine for raising blood pressure and its preparation |
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| Publication number | Publication date |
|---|---|
| CN1050047C (en) | 2000-03-08 |
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Owner name: SHANDONG DONGA DONKEY-HIDE CO., LTD. Free format text: FORMER NAME OR ADDRESS: SHANDONG DONG-E E-JIAO(GROUP)CO., LTD. |
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Address after: Dong'e County of Shandong province (contact: Wang Xinchun) Patentee after: Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov. Address before: Dong'e County of Shandong province (contact: Wang Xinchun) Patentee before: Dong'e Donkey-hide Gelatin (Group) Co., Ltd. Shandong |
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Expiration termination date: 20130816 Granted publication date: 20000308 |