CN108671269A - A kind of carried medicine sustained-release holder complex for treating infectious bone defect - Google Patents
A kind of carried medicine sustained-release holder complex for treating infectious bone defect Download PDFInfo
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- CN108671269A CN108671269A CN201810534821.1A CN201810534821A CN108671269A CN 108671269 A CN108671269 A CN 108671269A CN 201810534821 A CN201810534821 A CN 201810534821A CN 108671269 A CN108671269 A CN 108671269A
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The present invention relates to a kind of carried medicine sustained-release holder complexs for treating infectious bone defect, sustained-release micro-spheres are made by the encapsulating of vancomycin polylactide glycolic acid copolymer, and load on β tricalcium phosphate holders and be made.Sustained-release micro-spheres are made in vancomycin polylactide glycolic acid copolymer encapsulating with broad-spectrum antiseptic ability by the present invention, and load on β tricalcium phosphate holders, it is prepared into a kind of novel carried medicine sustained-release Anti-infective bone alternative materials that vancomycin can be discharged in the local slow of infectious bone defect, treatment applied to the infectious bone defect for the treatment of, so that after material implantation, it can be in the sectional perspective space of infectious bone defect, it is comprehensive, encapsulated vancomycin is discharged for a long time, achieve the purpose that in intralesional infection control, filling bone defects can also be played simultaneously, promote skeletonization, accelerate the effect that bone is rebuild.
Description
Technical field
The present invention relates to field of medical technology, are specifically related to a kind of carried medicine sustained-release branch for treating infectious bone defect
Frame complex.
Background technology
The infectious bone defect for the treatment of, simple bone grafting operation are likely to fail due to infection does not control, therefore patient is often not
One-stage bone grafting can be carried out, and needs thorough debridement, the second stage of bone grafting of row is repaired bone and lacked after infection elimination, wound healing, revascularization
Damage has the shortcomings that treatment cycle is long, medical expense is high, patient suffering is big.
The load antibiotic sustained release system of Recent study can effective infection control, but due to its without promote skeletonization make
With, thus the case where knitting delay or bone nonunion still happen occasionally.As can antibiotic Perceived control can be both released effectively by preparing
Dye, and can promote the self-bone grafting slow release stent material of skeletonization, it will for infectivity bone defect treatment provide an effective way and
Means.
Invention content
Technical problem to be solved by the invention is to provide a kind of carried medicine sustained-release holders for treating infectious bone defect
Complex, to overcome above-mentioned technical problem.
In order to solve the above technical problems, the present invention provides following technical scheme：It is a kind of to be used to treat infectious bone defect
Carried medicine sustained-release holder complex is made sustained-release micro-spheres by the encapsulating of vancomycin Poly(D,L-lactide-co-glycolide, and loads on
Bata-tricalcium phosphate holder is made.
On the basis of above-mentioned technical proposal, the preparation method of the sustained-release micro-spheres is：
It weighs 300mg vancomycins to be dissolved in 1ml deionized waters as inner aqueous phase, takes 500mg poly lactic-co-glycolic acids
Copolymer, which is dissolved in 9ml dichloromethane, is used as oil phase, inner aqueous phase is added newborn with ultrasonic cell disrupte machine 80w ultrasounds after oil phase
Change 20s, interval 3s three times, prepares stable milky mixed phase colostrum altogether；And the mixed phase colostrum is rapidly joined dropwise
In the outer aqueous phase of 40ml 2%PVA solution, it is organic that magnetic stirrer fixed rotating speed 1200r/min persistently stirs volatilization in 8-12 hours
Solvent stands 1h after microballoon precipitation, collects precipitation microballoon to centrifuge tube, it is micro- that sustained release is made in distillation water washing centrifugation negative pressure freeze-drying
Ball.
On the basis of above-mentioned technical proposal, the preparation method of the bata-tricalcium phosphate holder is：
Porous bata-tricalcium phosphate holder three-dimensional model, specification 5*5*5mm, bone trabecula diameter are designed with CAD graphics softwares
It it is 500 μm for 400 μm, pore size；Grain size is selected to be less than 38 μm of bata-tricalcium phosphate powder, by bata-tricalcium phosphate powder and binder
6% polyvinyl alcohol water solution is mixed into marking ink according to 5: 3 ratios, is printed with 3D printer, and marking ink injects pump pressure
For 200-400kPa, speed 6mm/s；It is dried at room temperature for after printing, and in muffle furnace prepared by 1100 DEG C of sintering 3h
Bata-tricalcium phosphate holder hard at quality, fine and closely woven.
On the basis of above-mentioned technical proposal, the method that the sustained-release micro-spheres load on bata-tricalcium phosphate holder is：
The chitosan solution 10ml that glacial acetic acid solution compound concentration with 1% is 2%, is slowly uniformly instilled with dropper and is soaked
Bata-tricalcium phosphate holder is placed on 37 DEG C of baking oven drying, this operation repeats 3 times, and bata-tricalcium phosphate holder is made to be coated with one layer of band just
The chitosan of charge；The bata-tricalcium phosphate holder that this was coated with to chitosan again is put into centrifuge tube, while being instilled negatively charged
Sustained-release micro-spheres distill aqueous suspensions, it is slight to shake mixing 10min, so that sustained-release micro-spheres uniform adsorption is filled in bata-tricalcium phosphate holder
In hole, 1000rpm centrifuges 5min, takes out material freeze-drying；There is the bata-tricalcium phosphate holder of sustained-release micro-spheres to impregnate this load again
Enter in chitosan solution, after soaking be impregnated with completely, takes out freeze-drying；
Bata-tricalcium phosphate is positively charged after the processing of chitosan package, can be by negatively charged sustained-release micro-spheres with Electrostatic Absorption
It is carried on bata-tricalcium phosphate holder with the method that chitosan wraps up again, carried medicine sustained-release holder complex is made.
The present invention has an advantageous effect in that compared with prior art：The present invention will be with the mould through the ages of broad-spectrum antiseptic ability
Sustained-release micro-spheres are made in the encapsulating of element Poly(D,L-lactide-co-glycolide, and load on bata-tricalcium phosphate holder, are prepared into a kind of energy
Enough local slows in infectious bone defect discharge the novel carried medicine sustained-release Anti-infective bone alternative materials of vancomycin, applied to controlling
Treat the treatment of infectious bone defect so that, can be in the sectional perspective space of infectious bone defect after material implantation, Quan Fang
Position discharges encapsulated vancomycin for a long time, achievees the purpose that in intralesional infection control, while can also play filling
Bone defect promotes skeletonization, accelerates the effect that bone is rebuild.Pass through physicochemical property, the inside and outside medicament slow release to constructed material
Dynamics, anti-infective and osteogenic action experimental study, verifying it has good therapeutic effect.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
A kind of carried medicine sustained-release holder complex for treating infectious bone defect, by vancomycin polylactic acid-glycolic base
Sustained-release micro-spheres are made in acetate multipolymer encapsulating, and load on bata-tricalcium phosphate holder and be made.
(1) preparation method of the sustained-release micro-spheres is：It weighs 300mg vancomycins and is dissolved in conduct in 1ml deionized waters
Inner aqueous phase, takes 500mg Poly(D,L-lactide-co-glycolides to be dissolved in 9ml dichloromethane and is used as oil phase, and oil is added in inner aqueous phase
Ultrasonic cell disrupte machine 80w ultrasonic emulsification 20s, interval 3s is used three times, to prepare stable milky mixed phase colostrum altogether after phase；
And the mixed phase colostrum is rapidly joined dropwise in the outer aqueous phase of 40ml 2%PVA solution, magnetic stirrer fixed rotating speed
1200r/min persistently stirs 8-12 hours volatile organic solvents, stands 1h after microballoon precipitation, collects precipitation microballoon and extremely centrifuges
Sustained-release micro-spheres are made in pipe, distillation water washing centrifugation negative pressure freeze-drying.
(2) preparation method of the bata-tricalcium phosphate holder is：Porous bata-tricalcium phosphate holder is designed with CAD graphics softwares
Three-dimensional model, specification 5*5*5mm, bone trabecula is 400 μm a diameter of, pore size is 500 μm；Grain size is selected to be less than 38 μm of β-
Bata-tricalcium phosphate powder and 6% polyvinyl alcohol water solution of binder are mixed into marking ink by tricresyl phosphate calcium powder according to 5: 3 ratios,
It is printed with 3D printer, it is 200-400kPa, speed 6mm/s that marking ink, which injects pump pressure,；After printing at room temperature
It is dry, and 1100 DEG C of sintering 3h are prepared into the bata-tricalcium phosphate holder that quality is hard, fine and closely woven in muffle furnace.
(3) method that the sustained-release micro-spheres load on bata-tricalcium phosphate holder is：It is prepared with 1% glacial acetic acid solution dense
Degree is 2% chitosan solution 10ml, is slowly uniformly instilled with dropper and soaks bata-tricalcium phosphate holder, is placed on 37 DEG C of baking ovens and dries
Dry, this operation repeats 3 times, and bata-tricalcium phosphate holder is made to be coated with one layer of positively charged chitosan；This was coated with chitosan again
Bata-tricalcium phosphate holder be put into centrifuge tube, while instilling negatively charged sustained-release micro-spheres distillation aqueous suspensions, slight concussion is mixed
Even 10min makes sustained-release micro-spheres uniform adsorption be filled in bata-tricalcium phosphate brace aperture, and 1000rpm centrifuges 5min, takes out material
Freeze-drying；There is the bata-tricalcium phosphate holder of sustained-release micro-spheres to be soaked into chitosan solution this load again, after soaking be impregnated with completely,
Take out freeze-drying；
Bata-tricalcium phosphate is positively charged after the processing of chitosan package, can be by negatively charged sustained-release micro-spheres with Electrostatic Absorption
It is carried on bata-tricalcium phosphate holder with the method that chitosan wraps up again, carried medicine sustained-release holder complex is made.
Sustained release is made in vancomycin Poly(D,L-lactide-co-glycolide encapsulating with broad-spectrum antiseptic ability by the present invention
Microballoon, and load on bata-tricalcium phosphate holder, be prepared into it is a kind of can be discharged in the local slow of infectious bone defect it is mould through the ages
The novel carried medicine sustained-release Anti-infective bone alternative materials of element.Wherein, the coating of chitosan can obviously slow down lacking for microballoon early stage burst release
Point；And Electrostatic Absorption and chitosan wrap up can make the stronger combination of microballoon on holder again.Load medicine provided by the invention is slow
Holder complex is released, the treatment of the infectious bone defect for the treatment of is applied to so that, can be in infectious bone defect after material implantation
Sectional perspective space in, it is comprehensive, discharge encapsulated vancomycin for a long time, reach the mesh in intralesional infection control
, while filling bone defects can also be played, promote skeletonization, accelerates the effect that bone is rebuild.Pass through the reason to constructed material
Change characteristic, inside and outside medicament slow release dynamics, anti-infective and osteogenic action experimental study, verifying it has good treatment effect
Fruit.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (4)
1. a kind of carried medicine sustained-release holder complex for treating infectious bone defect, it is characterised in that：It is used by vancomycin poly-
Sustained-release micro-spheres are made in poly lactic coglycolic acid encapsulating, and load on bata-tricalcium phosphate holder and be made.
2. the carried medicine sustained-release holder complex according to claim 1 for treating infectious bone defect, which is characterized in that
The preparation method of the sustained-release micro-spheres is：
It weighs 300mg vancomycins to be dissolved in 1ml deionized waters as inner aqueous phase, 500mg poly lactic-co-glycolic acids is taken to be copolymerized
Object, which is dissolved in 9ml dichloromethane, is used as oil phase, and ultrasonic cell disrupte machine 80w ultrasonic emulsifications are used after oil phase is added in inner aqueous phase
20s, interval 3s three times, prepare stable milky mixed phase colostrum altogether；And the mixed phase colostrum is rapidly joined dropwise
In the outer aqueous phase of 40ml 2%PVA solution, it is organic that magnetic stirrer fixed rotating speed 1200r/min persistently stirs volatilization in 8-12 hours
Solvent stands 1h after microballoon precipitation, collects precipitation microballoon to centrifuge tube, it is micro- that sustained release is made in distillation water washing centrifugation negative pressure freeze-drying
Ball.
3. the carried medicine sustained-release holder complex according to claim 1 for treating infectious bone defect, which is characterized in that
The preparation method of the bata-tricalcium phosphate holder is：
Porous bata-tricalcium phosphate holder three-dimensional model, specification 5*5*5mm, bone trabecula a diameter of 400 are designed with CAD graphics softwares
μm, pore size be 500 μm；It selects grain size to be less than 38 μm of bata-tricalcium phosphate powder, bata-tricalcium phosphate powder and binder 6% is gathered
Vinyl alcohol aqueous solution is mixed into marking ink according to 5: 3 ratios, is printed with 3D printer, and it is 200- that marking ink, which injects pump pressure,
400kPa, speed 6mm/s；It is dried at room temperature for after printing, and 1100 DEG C of sintering 3h are prepared into quality in muffle furnace
Hard, fine and closely woven bata-tricalcium phosphate holder.
4. the carried medicine sustained-release holder complex according to claim 1 for treating infectious bone defect, which is characterized in that
The method that the sustained-release micro-spheres load on bata-tricalcium phosphate holder is：
The chitosan solution 10ml that glacial acetic acid solution compound concentration with 1% is 2%, is slowly uniformly instilled with dropper and soaks β-phosphorus
Sour tricalcium holder is placed on 37 DEG C of baking oven drying, this operation repeats 3 times, keeps one layer of bata-tricalcium phosphate holder coating positively charged
Chitosan；The bata-tricalcium phosphate holder that this was coated with to chitosan again is put into centrifuge tube, while instilling negatively charged delay
Microballoon distillation aqueous suspensions are released, it is slight to shake mixing 10min, so that sustained-release micro-spheres uniform adsorption is filled in bata-tricalcium phosphate brace aperture
Interior, 1000rpm centrifuges 5min, takes out material freeze-drying；There is the bata-tricalcium phosphate holder of sustained-release micro-spheres to be soaked into shell this load again
In glycan solution, after soaking be impregnated with completely, freeze-drying is taken out；
Bata-tricalcium phosphate is positively charged after the processing of chitosan package, can be by negatively charged sustained-release micro-spheres with Electrostatic Absorption and shell
The method that glycan wraps up again is carried on bata-tricalcium phosphate holder, and carried medicine sustained-release holder complex is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810534821.1A CN108671269B (en) | 2018-05-24 | 2018-05-24 | Drug-loaded slow-release stent complex for treating infectious bone defects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810534821.1A CN108671269B (en) | 2018-05-24 | 2018-05-24 | Drug-loaded slow-release stent complex for treating infectious bone defects |
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| CN108671269A true CN108671269A (en) | 2018-10-19 |
| CN108671269B CN108671269B (en) | 2021-07-16 |
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Cited By (8)
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| CN110694109A (en) * | 2019-09-30 | 2020-01-17 | 季华实验室 | Calcium phosphate bone cement scaffold compounded with drug-loaded polymer microspheres and application |
| CN111467565A (en) * | 2020-06-03 | 2020-07-31 | 暨南大学 | Microtubule scaffold, preparation method and application thereof |
| CN111773433A (en) * | 2020-07-21 | 2020-10-16 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
| CN111790004A (en) * | 2020-06-17 | 2020-10-20 | 天津市康婷生物工程集团有限公司 | Preparation method of universal drug-loaded calcium-phosphorus cement porous scaffold |
| CN113730660A (en) * | 2021-09-03 | 2021-12-03 | 中国人民解放军新疆军区总医院 | 3D printing porous slow-release vancomycin tricalcium phosphate interstitial biological composite scaffold and preparation method and application thereof |
| CN114533968A (en) * | 2022-01-12 | 2022-05-27 | 重庆医科大学 | Vascularizable stent and preparation method thereof |
| CN114569539A (en) * | 2022-01-24 | 2022-06-03 | 赵振群 | Novel antibiotic release system, preparation method and application thereof |
| CN114681667A (en) * | 2022-02-16 | 2022-07-01 | 中南大学湘雅三医院 | Preparation method of drug-loaded sustained-release stent for filling bone defects with anti-osteosarcoma |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN111467565A (en) * | 2020-06-03 | 2020-07-31 | 暨南大学 | Microtubule scaffold, preparation method and application thereof |
| CN111467565B (en) * | 2020-06-03 | 2021-11-16 | 暨南大学 | Microtubule scaffold, preparation method and application thereof |
| CN111790004A (en) * | 2020-06-17 | 2020-10-20 | 天津市康婷生物工程集团有限公司 | Preparation method of universal drug-loaded calcium-phosphorus cement porous scaffold |
| CN111773433A (en) * | 2020-07-21 | 2020-10-16 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
| CN111773433B (en) * | 2020-07-21 | 2022-02-08 | 北京积水潭医院 | Preparation method of drug-loaded nano-bubble bone cement |
| CN113730660A (en) * | 2021-09-03 | 2021-12-03 | 中国人民解放军新疆军区总医院 | 3D printing porous slow-release vancomycin tricalcium phosphate interstitial biological composite scaffold and preparation method and application thereof |
| CN114533968A (en) * | 2022-01-12 | 2022-05-27 | 重庆医科大学 | Vascularizable stent and preparation method thereof |
| CN114569539A (en) * | 2022-01-24 | 2022-06-03 | 赵振群 | Novel antibiotic release system, preparation method and application thereof |
| CN114681667A (en) * | 2022-02-16 | 2022-07-01 | 中南大学湘雅三医院 | Preparation method of drug-loaded sustained-release stent for filling bone defects with anti-osteosarcoma |
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