CN108665375A - Consumptive material method of modifying for the production of full-automatic cell - Google Patents
Consumptive material method of modifying for the production of full-automatic cell Download PDFInfo
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- CN108665375A CN108665375A CN201810466110.5A CN201810466110A CN108665375A CN 108665375 A CN108665375 A CN 108665375A CN 201810466110 A CN201810466110 A CN 201810466110A CN 108665375 A CN108665375 A CN 108665375A
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- consumptive material
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- repacking
- cell production
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- 239000000463 material Substances 0.000 title claims abstract description 108
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000012857 repacking Methods 0.000 claims abstract description 38
- 239000003814 drug Substances 0.000 claims description 20
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 238000010923 batch production Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 230000009466 transformation Effects 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 41
- 239000000243 solution Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 206010054949 Metaplasia Diseases 0.000 description 2
- -1 cell factor Substances 0.000 description 2
- 238000005138 cryopreservation Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000015689 metaplastic ossification Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 210000004504 adult stem cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- G06Q50/00—Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
- G06Q50/04—Manufacturing
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/30—Computing systems specially adapted for manufacturing
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Abstract
Include the repacking carried out to the physical arrangement of consumptive material suitable for automation the present invention relates to the consumptive material method of modifying produced for full-automatic cell；Repacking suitable for automation is carried out to the occupation mode of consumptive material；The repacking of data tracing is carried out to consumptive material.The present invention passes through the demand according to automated production cell, the physical arrangement, occupation mode and notation methods of consumptive material are subjected to repacking processing, consumptive material is used cooperatively with automation equipment, complete the process of automatic cell production, it realizes and corresponding transformation is carried out according to the demand of automated production to consumptive material, cell batch production can be carried out and improve cell production efficiency and safety.
Description
Technical field
More specifically refer to the consumptive material method of modifying produced for full-automatic cell the present invention relates to cell production.
Background technology
Cell culture technology i.e. cell production technology refer to the growth of cell under in vitro conditions, in culture
Cell does not re-form tissue (animal) in the process.
In existing cell cultivation process, predominantly manual production mode relies on Semi-automatic device to be assisted.Therefore,
Consumptive material for cell culture is such as culture vessel class (culture bottle, culture bag, culture dish, cell factory), transfer container class
(Centrifuge Cup, centrifugal bottle, freeze bag, cryopreservation tube etc.) and medicament class (such as culture medium, cell factor, medicament) are according to hand
Work production design, these container class are not easy to automation equipment and are clamped and are transported since major part is cylindrical, for
The occupation mode of medicament class is not suitable for automated production, can not carry out cell batch production, leads to the reduction of cell production efficiency.
Therefore, it is necessary to design a kind of consumptive material method of modifying, realizes and consumptive material is carried out pair according to the demand of automated production
It should be transformed, cell batch production can be carried out and improve cell production efficiency and safety.
Invention content
It is an object of the invention to overcome the deficiencies of existing technologies, the consumptive material repacking produced for full-automatic cell is provided
Method.
To achieve the above object, the present invention uses following technical scheme：Consumptive material repacking for the production of full-automatic cell
Method, the method includes：
Repacking suitable for automation is carried out to the physical arrangement of consumptive material；
Repacking suitable for automation is carried out to the occupation mode of consumptive material；
The repacking of data tracing is carried out to consumptive material.
Its further technical solution is：The step of repacking suitable for automation is carried out to the physical arrangement of consumptive material, including
Step in detail below：
Reequip the physical appearance of consumptive material；
Increase automation mechanized operation point newly in consumptive material structure.
Its further technical solution is：The step of repacking suitable for automation is carried out to the occupation mode of consumptive material, including
Step in detail below：
Replace individually bottled medicament using the medicament for the formula that is pumped into；
It is only that single bottle is injected into cell production systems in the full-automatic warehousing system and automation movement system of cell production
The medicament of vertical packing.
Its further technical solution is：The step of repacking of data tracing is carried out to consumptive material, including step in detail below：
To consumptive material labels tokens；
The mark of consumptive material is obtained using scan code system；
Mark is stored in database, using data base administration and tracks the mark of consumptive material.
Its further technical solution is：Cylindrical consumptive material, is specifically adapted as by the step of reequiping the physical appearance of consumptive material
Polygon consumptive material.
Its further technical solution is：In the step of increasing automation mechanized operation point in consumptive material structure newly, the automation mechanized operation
Point includes mechanical arm bite, sucker position and magnetic bite.
Its further technical solution is：To the physical arrangement of consumptive material carry out suitable for automation repacking the step of include：
External in flexible consumptive material installs shell additional.
Its further technical solution is：In external the step of installing shell additional of flexible consumptive material, specifically in the outer of culture bag
Portion installs shell additional.
Its further technical solution is：In external the step of installing shell additional of flexible consumptive material, specifically the outer of bag is being frozen
Portion installs shell additional.
Its further technical solution is：After the step of increasing automation mechanized operation point in consumptive material structure newly, further include：
The pipeline and connector that installation is connect with automation pump injection system on culture medium.
Compared with the prior art, the invention has the advantages that：The consumptive material for full-automatic cell production of the present invention changes
Dress method is carried out the physical arrangement, occupation mode and notation methods of consumptive material by the demand according to automated production cell
Repacking is handled so that consumptive material can be used cooperatively with automation equipment, complete the process of automatic cell production, be realized to consumptive material
Corresponding transformation is carried out according to the demand of automated production, cell batch production can be carried out and improve cell production efficiency and safety
Property.
The invention will be further described in the following with reference to the drawings and specific embodiments.
Description of the drawings
Fig. 1 is the flow for the consumptive material method of modifying for full-automatic cell production that the specific embodiment of the invention provides
Figure；
Fig. 2 is the stream for the repacking that the physical arrangement to consumptive material that the specific embodiment of the invention provides is carried out suitable for automation
Cheng Tu；
Fig. 3 is the stream for the repacking that the occupation mode to consumptive material that the specific embodiment of the invention provides is carried out suitable for automation
Cheng Tu；
Fig. 4 is the flow chart for the repacking that data tracing is carried out to consumptive material that the specific embodiment of the invention provides.
Specific implementation mode
In order to more fully understand the present invention technology contents, with reference to specific embodiment to technical scheme of the present invention into
One step introduction and explanation, but not limited to this.
Specific embodiment as shown in figures 1-4, the consumptive material repacking provided in this embodiment for full-automatic cell production
Method can be used in the various cells such as culture immunocyte, stem cell, adult cell, realize to consumptive material according to automatic metaplasia
The demand of production carries out corresponding transformation, can carry out cell batch production and improve cell production efficiency and safety.
As shown in Figure 1, present embodiments providing the consumptive material method of modifying produced for full-automatic cell, this method packet
It includes：
S1, the repacking suitable for automation is carried out to the physical arrangement of consumptive material；
S2, the repacking suitable for automation is carried out to the occupation mode of consumptive material；
S3, the repacking that data tracing is carried out to consumptive material.
Include the consumptive material used suitable for various cell culture or cell production for above-mentioned consumptive material, including but not
It is limited to：(Centrifuge Cup, freezes centrifugal bottle culture vessel class (culture bottle, culture bag, culture dish, cell factory etc.) transfer container class
Bag, cryopreservation tube etc.) and medicament class (such as culture medium, cell factor, medicament).
Further, for above-mentioned S1 steps, the repacking suitable for automation is carried out to the physical arrangement of consumptive material
Step, including step in detail below：
S11, the physical appearance for reequiping consumptive material；
S12, automation mechanized operation point is increased newly in consumptive material structure.
For above-mentioned S11 steps, change the physical appearance of consumptive material, it is made to facilitate the behaviour of automation movement system
Make.One of example is cylindrical consumptive material to be adapted as polygon consumptive material, for example circular body is changed into polygon
Body, including but not limited to quadrangle, hexagon, octagon and other multilateral shapes.
For above-mentioned S12 steps, automation mechanized operation point is increased newly in consumptive material structure, above-mentioned automation mechanized operation point includes
But it is not limited to mechanical arm bite, sucker position, magnetic bite.
In addition, in other embodiments, for above-mentioned S1 steps, further including：External in flexible consumptive material installs shell additional.
It is outer in the external shell installed additional suitable for automated production of flexible consumptive material, such as in the external installation of culture bag
Shell；For another example in the external installation shell for freezing bag.
The shape accuracy of manufacture for increasing consumptive material, increases the operational stability of automation operating system.
For above-mentioned S2 steps, the step of carrying out being suitable for the repacking of automation to the occupation mode of consumptive material, including with
Lower specific steps：
S21, replace individually bottled medicament using the medicament for the formula that is pumped into；
S22, the full-automatic warehousing system produced in cell and automation movement system are injected single into cell production systems
The medicament that bottle independently dispenses.
Specifically, above-mentioned S21 steps are pumped into the larger medicament of dosage using the formula of being pumped into, replace individually bottled medicament,
In certain implementation examples, medicament collocation is completed the process of automatic on-line disinfection, is carried using the sterilization system on line system of pump injection system
High efficiency.
For above-mentioned S22 steps, coordinate full-automatic warehousing system and automation movement system into cell production systems
The medicament that injection usage amount is smaller, single bottle independently dispenses.In certain implementation examples, medicament collocation use independently dispenses
The database of consumptive material, is in charge of, and the service efficiency of medicament is improved, to improve the efficiency of cell production.
In other embodiment, above-mentioned S22 steps, after the step of increasing automation mechanized operation point in consumptive material structure newly,
Further include：
The pipeline and connector that installation is connect with automation pump injection system on culture medium.
In addition, for above-mentioned S3 steps, the step of repacking of data tracing is carried out to consumptive material, including walk in detail below
Suddenly：
S31, to consumptive material labels tokens；
S32, the mark that consumptive material is obtained using scan code system；
S33, mark is stored in database, using data base administration and tracks the mark of consumptive material.
To consumptive material carry out data tracing repacking it is this repacking include but not limited to：Consumptive material is tracked using coded system
Unique mark.Coded system includes but not limited to one-dimension code, Quick Response Code and RFID；Consumption is obtained using full-automatic scan code system
The unique designation of material, scan code system include but not limited to laser barcode scanning gun, industrial camera, RFID identification device etc.；Use data
Library manages and tracks the unique designation of consumptive material.
Each consumptive material is labeled and is tracked, is conducive to, to the tracking cell in cell cultivation process, examine in quality
During survey or productive culture, it can be traced according to mark.
For example：For culture bottle, the body suitable for automation is repacked into, one of example includes having
The appearance for having polygon facilitates the transhipment of automation movement system；It is suitable for automatic metaplasia in external install additional of flexibly foster bag
The shell of production facilitates the transhipment of automation movement system；Install automation transhipment repacking point outside culture dish ware body additional, it can be direct
It is transported through, is uncapped, the operations such as micro- sem observation using automation movement system；The cup body of Centrifuge Cup, which repacks into, to be suitable for
The cup body of automation, one of example include that the appearance with polygon facilitates the transhipment of automation movement system, cup body
With transparent appearance, vision system is facilitated to read liquid level, the delamination after identification centrifugation automatically；In the outer of flexibly foster bag
Portion installs the shell suitable for automated production additional, facilitates the transhipment of automation movement system；It is arranged and automates pump on culture medium
The pipeline and connector that injection system is connected provide level gauging, low liquid level warning, injection rate statistics etc..
By after above-mentioned repacking consumptive material and automation equipment combine and form cell factory, the cell factory have automation
Transhipment repacking point can be directly transported through using automation movement system, carry out injection liquid, take out the operations such as liquid.
The above-mentioned consumptive material method of modifying for full-automatic cell production, passes through the need according to automated production cell
It asks, the physical arrangement, occupation mode and notation methods of consumptive material is subjected to repacking processing so that consumptive material can be with automation equipment
It is used cooperatively, completes the process of automatic cell production, realize and corresponding transformation is carried out according to the demand of automated production to consumptive material,
It can carry out cell batch production and improve cell production efficiency and safety.
It is above-mentioned only with embodiment come the technology contents that further illustrate the present invention, in order to which reader is easier to understand, but not
It represents embodiments of the present invention and is only limitted to this, any technology done according to the present invention extends or recreation, by the present invention's
Protection.Protection scope of the present invention is subject to claims.
Claims (10)
1. the consumptive material method of modifying for full-automatic cell production, which is characterized in that the method includes：
Repacking suitable for automation is carried out to the physical arrangement of consumptive material；
Repacking suitable for automation is carried out to the occupation mode of consumptive material；
The repacking of data tracing is carried out to consumptive material.
2. the consumptive material method of modifying according to claim 1 for full-automatic cell production, which is characterized in that consumptive material
Physical arrangement the step of carrying out the repacking suitable for automation, including step in detail below：
Reequip the physical appearance of consumptive material；
Increase automation mechanized operation point newly in consumptive material structure.
3. the consumptive material method of modifying according to claim 2 for full-automatic cell production, which is characterized in that consumptive material
Occupation mode the step of carrying out the repacking suitable for automation, including step in detail below：
Replace individually bottled medicament using the medicament for the formula that is pumped into；
Single bottle is injected into cell production systems and is independently divided in the full-automatic warehousing system and automation movement system of cell production
The medicament of dress.
4. the consumptive material method of modifying according to any one of claims 1 to 3 for full-automatic cell production, feature exists
In, the step of repacking of data tracing is carried out to consumptive material, including step in detail below：
To consumptive material labels tokens；
The mark of consumptive material is obtained using scan code system；
Mark is stored in database, using data base administration and tracks the mark of consumptive material.
5. the consumptive material method of modifying according to claim 2 for full-automatic cell production, which is characterized in that repacking consumption
Cylindrical consumptive material is specifically adapted as polygon consumptive material by the step of physical appearance of material.
6. the consumptive material method of modifying according to claim 2 for full-automatic cell production, which is characterized in that in consumptive material
In structure increase newly automation mechanized operation point the step of, the automation mechanized operation point include mechanical arm bite, sucker position and
Magnetic bite.
7. the consumptive material method of modifying according to claim 1 for full-automatic cell production, which is characterized in that consumptive material
Physical arrangement carry out suitable for automation repacking the step of include：External in flexible consumptive material installs shell additional.
8. the consumptive material method of modifying according to claim 7 for full-automatic cell production, which is characterized in that in flexibility
External the step of installing shell additional of consumptive material, specifically installs shell additional in the external of culture bag.
9. the consumptive material modifying system according to claim 8 for full-automatic cell production, which is characterized in that in flexibility
External the step of installing shell additional of consumptive material, specifically in the external installation shell for freezing bag.
10. the consumptive material modifying system according to claim 2 for full-automatic cell production, which is characterized in that consuming
After the step of increasing automation mechanized operation point in material structure newly, further include：
The pipeline and connector that installation is connect with automation pump injection system on culture medium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810466110.5A CN108665375A (en) | 2018-05-16 | 2018-05-16 | Consumptive material method of modifying for the production of full-automatic cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810466110.5A CN108665375A (en) | 2018-05-16 | 2018-05-16 | Consumptive material method of modifying for the production of full-automatic cell |
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Family
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102061260A (en) * | 2010-12-01 | 2011-05-18 | 汪华 | Medical automatic cell production device and production method thereof |
| CN102174395A (en) * | 2011-01-30 | 2011-09-07 | 中国科学院广州生物医药与健康研究院 | Automation augmentation and culture system of induced pluripotent stem cells |
| CN102965395A (en) * | 2012-11-21 | 2013-03-13 | 苏州大学 | Method for automatically scanning and recording cell culture dish and tracking and positioning interested cell |
| CN203021572U (en) * | 2012-11-28 | 2013-06-26 | 中国科学院广州生物医药与健康研究院 | Cell cultivation box with intelligent identification and conveying function |
| CN104946530A (en) * | 2015-05-07 | 2015-09-30 | 中国航天员科研训练中心 | Automatic passage type cell long-term experiment integrated module capable of being used for observing on line in real time |
| CN105505760A (en) * | 2015-12-31 | 2016-04-20 | 上海白泽医疗器械有限公司 | Full-automatic non-centrifugal closed cell washing system |
| US20160264273A1 (en) * | 2015-03-13 | 2016-09-15 | NPK Packaging, LLC | Automatic Grading, Sorting and Packaging System |
-
2018
- 2018-05-16 CN CN201810466110.5A patent/CN108665375A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102061260A (en) * | 2010-12-01 | 2011-05-18 | 汪华 | Medical automatic cell production device and production method thereof |
| CN102174395A (en) * | 2011-01-30 | 2011-09-07 | 中国科学院广州生物医药与健康研究院 | Automation augmentation and culture system of induced pluripotent stem cells |
| CN102965395A (en) * | 2012-11-21 | 2013-03-13 | 苏州大学 | Method for automatically scanning and recording cell culture dish and tracking and positioning interested cell |
| CN203021572U (en) * | 2012-11-28 | 2013-06-26 | 中国科学院广州生物医药与健康研究院 | Cell cultivation box with intelligent identification and conveying function |
| US20160264273A1 (en) * | 2015-03-13 | 2016-09-15 | NPK Packaging, LLC | Automatic Grading, Sorting and Packaging System |
| CN104946530A (en) * | 2015-05-07 | 2015-09-30 | 中国航天员科研训练中心 | Automatic passage type cell long-term experiment integrated module capable of being used for observing on line in real time |
| CN105505760A (en) * | 2015-12-31 | 2016-04-20 | 上海白泽医疗器械有限公司 | Full-automatic non-centrifugal closed cell washing system |
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