CN108659087A - A kind of extraction process of cucurbitacin D - Google Patents
A kind of extraction process of cucurbitacin D Download PDFInfo
- Publication number
- CN108659087A CN108659087A CN201810688643.8A CN201810688643A CN108659087A CN 108659087 A CN108659087 A CN 108659087A CN 201810688643 A CN201810688643 A CN 201810688643A CN 108659087 A CN108659087 A CN 108659087A
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- CN
- China
- Prior art keywords
- cucurbitacin
- muskmelon pedicel
- crushed
- concentrated
- ethyl alcohol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of extraction processes of cucurbitacin D, include the following steps：1), muskmelon pedicel feeding pulverizer is crushed, the muskmelon pedicel crushed；2) muskmelon pedicel of crushing, is carried out alcohol reflux twice to extract, to obtain extracting solution；3), extracting solution is concentrated, isolated ethyl acetate layer；4) it and then by ethyl acetate layer is concentrated to dryness, adds 10% pyridine and ethyl alcohol, flow back 2.5 3.5 hours, isolated cucurbitacin D.A large amount of Cucurbitacin B in muskmelon pedicel, as weak base, is converted to cucurbitacin D, and carry out separation and Extraction, substantially increases the recovery rate of cucurbitacin D, and simple process and low cost by the present invention using 10% pyridine and ethyl alcohol.
Description
Technical field
The present invention relates to a kind of extraction processes of cucurbitacin D.
Background technology
Cucurbitacin D molecular formula are C30H44O7, molecular weight 516.67, white acicular crystal at normal temperatures and pressures, mainly
From the carpopodium of Curcurbitaceae muskmelon platymiscium muskmelon, be dissolved in chloroform, be slightly soluble in methanol, be practically insoluble in water, at room temperature compared with
It is preferable for stability, need to be placed in be protected from light shady place preservation.
Currently, when carrying out the extraction of cucurbitacin D from the carpopodium of Curcurbitaceae muskmelon platymiscium muskmelon, extraction is not thorough enough,
It is of high cost, cannot meet the needs of market.
Invention content
In view of the above-mentioned problems, the present invention provides a kind of extraction process of cucurbitacin D, method is simple, and extraction is thorough, and at
This is low.
The technical solution adopted by the present invention is：
A kind of extraction process of cucurbitacin D, includes the following steps：
1), muskmelon pedicel feeding pulverizer is crushed, the muskmelon pedicel crushed；
2) muskmelon pedicel of crushing, is carried out alcohol reflux twice to extract, to obtain extracting solution；
3), extracting solution is concentrated, isolated ethyl acetate layer；
4) it and then by ethyl acetate layer is concentrated to dryness, adds 10% pyridine and ethyl alcohol, flow back 2.5-3.5 hours, point
From obtaining cucurbitacin D.
Preferably, in the step 2) ethyl alcohol a concentration of 60-85%, a concentration of 30- of ethyl alcohol in the step 4)
50%.
A large amount of Cucurbitacin B in muskmelon pedicel, as weak base, is converted to cucurbit by the present invention using 10% pyridine and ethyl alcohol
Plain D, and separation and Extraction is carried out, substantially increase the recovery rate of cucurbitacin D, and simple process and low cost.
Specific implementation mode
The present invention is described in further detail below by specific embodiment.
A kind of extraction process of cucurbitacin D, includes the following steps：
1), muskmelon pedicel feeding pulverizer is crushed, the muskmelon pedicel crushed；
2) muskmelon pedicel of crushing, is carried out alcohol reflux twice to extract, to obtain extracting solution, a concentration of 60- of ethyl alcohol
85%；
3), extracting solution is concentrated, isolated ethyl acetate layer；
4) it and then by ethyl acetate layer is concentrated to dryness, adds the ethyl alcohol of 10% pyridine and a concentration of 30-50%, return
Stream 2.5-3.5 hours, isolated cucurbitacin D.
Claims (2)
1. a kind of extraction process of cucurbitacin D, which is characterized in that include the following steps：
1), muskmelon pedicel feeding pulverizer is crushed, the muskmelon pedicel crushed；
2) muskmelon pedicel of crushing, is carried out alcohol reflux twice to extract, to obtain extracting solution；
3), extracting solution is concentrated, isolated ethyl acetate layer；
4) it and then by ethyl acetate layer is concentrated to dryness, adds 10% pyridine and ethyl alcohol, flow back 2.5-3.5 hours, detach
To cucurbitacin D.
2. the extraction process of cucurbitacin D according to claim 1 a kind of, which is characterized in that ethyl alcohol in the step 2)
A concentration of 60-85%, a concentration of 30-50% of ethyl alcohol in the step 4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810688643.8A CN108659087A (en) | 2018-06-28 | 2018-06-28 | A kind of extraction process of cucurbitacin D |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810688643.8A CN108659087A (en) | 2018-06-28 | 2018-06-28 | A kind of extraction process of cucurbitacin D |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108659087A true CN108659087A (en) | 2018-10-16 |
Family
ID=63773420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810688643.8A Withdrawn CN108659087A (en) | 2018-06-28 | 2018-06-28 | A kind of extraction process of cucurbitacin D |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108659087A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110041392A (en) * | 2019-02-27 | 2019-07-23 | 浙江工业大学 | A kind of preparation method of cucurbitacin D |
-
2018
- 2018-06-28 CN CN201810688643.8A patent/CN108659087A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110041392A (en) * | 2019-02-27 | 2019-07-23 | 浙江工业大学 | A kind of preparation method of cucurbitacin D |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181016 |