CN108653847A - Integral type blood plasma detaches AIDS virus immuno absorbence device - Google Patents
Integral type blood plasma detaches AIDS virus immuno absorbence device Download PDFInfo
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- CN108653847A CN108653847A CN201810141489.2A CN201810141489A CN108653847A CN 108653847 A CN108653847 A CN 108653847A CN 201810141489 A CN201810141489 A CN 201810141489A CN 108653847 A CN108653847 A CN 108653847A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/20—Pathogenic agents
- A61M2202/206—Viruses
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- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses integral type blood plasma to detach AIDS virus immuno absorbence device, including shell, the blood entry port being connected on shell and with its inside, blood outlet and plasma outlet port, the inner cavity of shell are equipped with disengagement chamber and adsorbent chamber；The inner cavity both ends of shell are equipped with sealing ring；Hollow-fiber film is equipped in disengagement chamber；The both ends of hollow-fiber film, which plug, to be fixed on sealing ring and is connected to blood entry port and blood outlet；Disengagement chamber is connected to adsorbent chamber by the first perforated film for only allowing blood plasma to penetrate；AIDS virus immunosorbent is equipped in adsorbent chamber.Beneficial effects of the present invention：By the way that disengagement chamber and adsorbent chamber is arranged, blood plasma separation progress synchronous with plasma adsorption may be implemented, avoid haemocyte and being in direct contact for adsorbent and improve biocompatibility；Regenerative therapy pattern or single adsorptions treatment mode can be independently selected according to conditions of patients；Consumables cost and treatment cost are reduced, adsorption effect is improved.
Description
Technical field
The present invention relates to medical instruments fields, and AIDS virus immuno absorbence is detached in particular to a kind of integral type blood plasma
Device.
Background technology
AIDS virus immunosorbent is a kind of filler of anti AIDS virus antibody-carrier complexes, it passes through chemical bond
Effect by anti AIDS virus antibody coupling on carrier matrix, utilize the selection of anti AIDS virus antibody on human body AIDS virus
Property combine adsorbed.AIDS virus immuno absorbence therapy is a kind of new technology to grow up in recent decades, is mainly used for
Treat AIDS.
Plasma sorption therapy compares whole blood sorption therapy, small to injury of blood cell, small on human internal environment's influence, in blood
Field of purification is used widely.The basic principle of plasma sorption therapy is to guide to patient's body blood in vitro, first by blood plasma
It detaches with haemocyte, then is targetedly adsorbed and removed the morbid substance in blood plasma, to achieve the purpose that treat disease.
Current existing immunoadsorption therapy technology is that blood first enters plasma separator after human body outflow through blood pump
It is interior, blood plasma and haemocyte are separated by the sieving actoion of plasma separator, then by the blood plasma isolated by blood pump again
It is introduced into immunoabsorbent column, blood plasma is targetedly removed using the suction-operated of the immunosorbent loaded in immunoabsorbent column
In morbid substance.Wherein, what is filled in plasma separator is hollow-fiber film.Concatenated equipment is more during this, doctor
The operation difficulty of shield personnel is larger, and the blood volume of extracorporal circulatory system is larger, and the medical instrument of contact is more, this is increasing trouble
The probability that the problems such as also making haemolysis, blood coagulation while the body burden of person occurs increases, and increases security risk when treatment.Separately
Outside, a full set of plasma adsorption equipment cost is also relatively high.These above-mentioned problems cause traditional plasma separator to add immunoabsorbent column
Treatment mode be difficult to be widely popularized at home.
The Chinese patent of Patent No. CN 102631722B discloses a kind of blood plasma separation absorption carrying out blood purification
Device may be implemented blood plasma separation and be carried out with while plasma adsorption, however the absorber is used to adsorb the adsorption material of morbid substance
Material is the adsorbent of threadiness, and there are theoretical defects and technical bottleneck.
First, fibrous adsorbent is on the one hand because its specific area is limited (the two difference decades of times), on the other hand because of it
Blood residence time (sorbing material and contacting blood time) is shorter in adsorption process, and the adsorption capacity of Fibriform adsorbents is very
It is limited, it cannot be satisfied medical standard (seeming an utterly inadequate amount particularly with the morbid substance in the human blood of complicated component)；Secondly,
Adsorbent manufacturing process complexity, the technology of threadiness require height, current medical Fibriform adsorbents to be substantially at laboratory rank
Section, the country there is no the blood purification Related product of any Fibriform adsorbents, external also to only have a product of toray
Toraymyxin, and the product can only also be directed to disease caused by low abundance morbid substance, can not be applied to AIDS virus
The corresponding indication of immuno absorbence, especially patient with severe symptoms.
And consider safety, the volume of adsorbent can not be infinitely great in absorber, as advised in professional standard YY0464
200ml cannot be more than by having determined the blood chamber vol of absorber, and corresponding adsorbent volume is generally no greater than 400ml.Just because of this,
The adsorbent single adsorptions ability of threadiness is limited, and part patient with severe symptoms needs the morbid substance being purged often to surpass
The adsorption capacity for going out single branch adsorption column is limited to adsorption capacity, and part patient with severe symptoms clinically needs progress, and " absorption-is again
This circulation pattern of life-absorption " meets clinical treatment to achieve the purpose that promotion adsorption capacity.And existing absorber without
Method realizes " absorption-regeneration-absorption " this circulation pattern.
In addition, it is necessary to, it is noted that the patent disclosure of Publication No. CN 102631722B absorber inside there is no into
Row subregion causes the Fibriform adsorbents in shell to exist and adsorbs non-uniform situation, leads to its practical adsorption effect and pay no attention to
Think, adsorbent further increases patient's treatment cost using not exclusively.
Invention content
The purpose of the present invention is to provide a kind of integral type blood plasma to detach AIDS virus immuno absorbence device, has absorption
Effect is good, consumables cost and the low feature for the treatment of cost.
To achieve the above object, the integral type blood plasma designed by the present invention detaches AIDS virus immuno absorbence device, including
Shell, the blood entry port being connected on the shell and with its inside, blood outlet and plasma outlet port, the inner cavity of the shell
Equipped with disengagement chamber and adsorbent chamber；The inner cavity both ends of the shell are equipped with sealing ring；Hollow-fiber film is equipped in the disengagement chamber；Institute
State hollow-fiber film both ends plug be fixed on the sealing ring and be connected to the blood entry port and blood outlet；The disengagement chamber
It is connected to by the first perforated film for only allowing blood plasma to penetrate with adsorbent chamber；AIDS virus immuno absorbence is equipped in the adsorbent chamber
Agent；The adsorbent chamber is connected to the plasma outlet port.
Further, it is additionally provided in the adsorbent chamber and adsorbent chamber is divided into only permitting for the first adsorbent chamber and the second adsorbent chamber
Perhaps the second perforated film that blood plasma penetrates；First adsorbent chamber is connected to the disengagement chamber by first perforated film；It is described
It is divided into multiple independent cavitys equipped with multiple non-porous films in first adsorbent chamber, it is linear to be equipped with wave in each cavity
Adsorbent coherent film；The adsorbent coherent film is equipped with AIDS virus immunosorbent；Second adsorbent chamber and institute
Plasma outlet port connection is stated, the AIDS virus immunosorbent of free shape is equipped in second adsorbent chamber.Pass through multiple independences
Cavity effect so that adsorption space is divided, and avoids the adsorption effect of blood plasma by absorber placement position and angle
It influences, to ensure that effective absorption of blood plasma；Wavy adsorbent coherent film also improves adsorption area simultaneously, while
Supporting surface is provided for AIDS virus immunosorbent, prevents AIDS virus immunosorbent from tenesmus precipitation occurs and influences to inhale
Attached effect.
Preferably, adsorbent coherent film lower end is equipped with thickening part.By the setting of thickening part, adsorbent can be improved
Coherent film bears dynamics, prevents its rupture.
Still further, being additionally provided with the adding mouth being connected to the adsorbent chamber on the shell；The adding mouth passes through pipe
Road has been sequentially communicated pump and regenerated liquid.Pass through the effect of regenerated liquid so that absorber can realize " absorption-regeneration-absorption " this
One circulation pattern, to reach ideal therapeutic effect.
Preferably, the adding mouth being connected to second adsorbent chamber is additionally provided on the shell；The adding mouth passes through pipe
Road has been sequentially communicated pump and regenerated liquid.
Further, the volume of the AIDS virus immunosorbent is 50~1000mL.
Preferably, the surface area of the hollow-fiber film is 0.1~2.0 ㎡.
Further, the disengagement chamber is equipped with close to one end of the first perforated film for stopping that regenerated liquid enters in disengagement chamber
Barrier film, and barrier film is flexibly connected with shell.Beneficial effects of the present invention：1, divided by being arranged in the inner cavity of absorber
From chamber and adsorbent chamber, blood plasma separation progress synchronous with plasma adsorption may be implemented, avoid the direct of haemocyte and adsorbent
It contacts and improves biocompatibility；2, regenerative therapy pattern or single adsorptions can independently be selected to treat according to conditions of patients
Pattern, wherein single adsorptions treatment mode can reduce the blood volume of extracorporal circulatory system；3, traditional treatment mode is compared, is reduced
Consumables cost and treatment cost；4, existing Fibriform adsorbents, the AIDS virus immunosorbent in the present invention are compared
Adsorption effect is more preferable；5, it by the way that adsorbent chamber is divided into the first adsorbent chamber and the second adsorbent chamber, realizes that the classification to blood plasma is adsorbed, inhales
Attached effect is more preferable.
Description of the drawings
Fig. 1 is that a kind of structure of embodiment of the integral type blood plasma separation AIDS virus immuno absorbence device of the present invention is shown
It is intended to.
Fig. 2 is the structure that the integral type blood plasma of the present invention detaches the another embodiment of AIDS virus immuno absorbence device
Schematic diagram.
Fig. 3 is the partial enlargement structural representation of Fig. 2.
Fig. 4 is the treatment schematic diagram of Fig. 2.
In figure, 1. shells；2. blood entry port；3. blood exports；4. plasma outlet port；5. disengagement chamber；6. adsorbent chamber；7. sealing
Circle；8. hollow-fiber film；9. the first perforated film；10. AIDS virus immunosorbent；11. adding mouth；12. pump；13. regeneration
Liquid；14. the first adsorbent chamber；15. the second adsorbent chamber；16. the second perforated film；17. cavity；18. adsorbent coherent film；19. non-porous
Film；20. thickening part；21. barrier film.
Specific implementation mode
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Embodiment 1
Integral type blood plasma as shown in Figure 1 detaches AIDS virus immuno absorbence device, including shell 1, is set on shell 1 simultaneously
With its internal blood entry port 2 being connected to, blood outlet 3 and plasma outlet port 4, the inner cavity of shell 1 is equipped with disengagement chamber 5 and adsorbent chamber 6；
The inner cavity both ends of shell 1 are equipped with sealing ring 7；Hollow-fiber film 8 is equipped in disengagement chamber 5；The both ends of hollow-fiber film 8 plug fixation
In sealing ring 7 and it is connected to blood entry port 2 and blood outlet 3；Disengagement chamber 5 and adsorbent chamber 6 are by only allowing blood plasma in blood to penetrate
The first perforated film 9 connection；AIDS virus immunosorbent 10 is equipped in adsorbent chamber 6；Adsorbent chamber 6 is connected to plasma outlet port 4.
The adding mouth 11 being connected to adsorbent chamber 6 is additionally provided on shell 1；Adding mouth 11 has been sequentially communicated pump 12 and regenerated liquid by pipeline
13.Disengagement chamber 5 is equipped with the barrier film 21 entered in disengagement chamber 5 for stopping regenerated liquid 13 close to one end of the first perforated film 9, and
Barrier film 21 is flexibly connected with shell 1；Pass through the effect of regenerated liquid 13 so that absorber can be realized " absorption-regeneration-absorption "
This circulation pattern, to reach ideal therapeutic effect.The volume of AIDS virus immunosorbent 10 is preferably 50~
1000mL.The surface area of hollow-fiber film 8 is preferably 0.1~2.0 ㎡.
Wherein, AIDS virus immunosorbent 10 is not particularly limited in the present invention, is made of carrier-aglucon.But
The representative carrier of AIDS virus immunosorbent 10, including polysaccharide, such as agarose, cellulose, cellulose acetate and dextrin；
Synthetic polymer, as polystyrene, styrene-divinylbenzene copolymer, polyacrylamide, polyacrylic acid, polymethylacrylic acid,
Polyacrylate, polymethacrylates and polyvinyl alcohol.Porous carrier not soluble in water can have coatings, it includes with
The polymer material of hydroxyl, such as the polymer of hydroxyethyl meth acrylate, graft copolymer is as with polyethylene oxide chain
The copolymer etc. of monomer and another polymerisable monomer.In these carrier materials, preferably agarose, cellulose and polyvinyl alcohol,
Because these materials can very easily introduce active group while with good biocompatibility.AIDS virus is exempted from
The representative aglucon of epidemic disease adsorbent 10 includes anti AIDS virus antibody, recombinates AIDS virus antibody, biomimetic ligands and other tools
There is the molecule of same or like function.
Hollow-fiber film 8 can directly use commercial product, such as the blood plasma separation of polyether sulfone, polysulfones, polypropylene material
Film etc., but it is not limited to above-mentioned material.It is preferred that the hollow-fiber film of the preferable polyether sulfone of biocompatibility, polysulfones material.Mesh
The production technology of preceding hollow-fiber film 8 comparative maturity, can be bought by commercial sources.
Embodiment 2
Integral type blood plasma as shown in figs. 2 to 4 detaches AIDS virus immuno absorbence device, the present embodiment and embodiment 1
Main feature is identical, and distinguishing characteristics is：It is additionally provided in adsorbent chamber 6 and adsorbent chamber 6 is divided into the suction of the first adsorbent chamber 14 and second
Attached chamber 15 only allows the second perforated film 16 that blood plasma penetrates in blood, the second perforated film 16 that regenerated liquid 13 is allowed to penetrate；This
" only allow blood plasma transmission in blood " in specification or " only allowing blood plasma transmission " refers to the only blood plasma that can pass through in blood, and simultaneously
Only blood plasma can pass through in not all substance (blood and other)；First adsorbent chamber 14 is connected with disengagement chamber 5 by the first perforated film 9
It is logical；It is divided into multiple independent cavitys 17 equipped with multiple non-porous films 19 in first adsorbent chamber 14, is equipped in each cavity 17
The adsorbent coherent film 18 of wave threadiness；Adsorbent coherent film 18 is equipped with AIDS virus immunosorbent 10；Second absorption
Chamber 15 is connected to plasma outlet port 4, and the AIDS virus immunosorbent 10 of free shape is equipped in the second adsorbent chamber 15.By multiple
The effect of independent cavity 17 so that adsorption space is divided, avoid the adsorption effect of blood plasma by absorber placement position and
The influence of angle, to ensure that effective absorption of blood plasma；For example, working as the existing absorber vertical display for not carrying out subregion
When, adsorbent is generally in absorber lower end, and causes upper end blood plasma that cannot effectively adsorb, and causes plasma adsorption effect poor,
It adsorbs uneven, and influences therapeutic effect.Wavy adsorbent coherent film 18 also improves adsorption area simultaneously, especially inhales
When attached dose of 18 direction as shown in Figure 3 of coherent film arrangement, blood plasma needs just enter second after repeatedly penetrating adsorbent coherent film 18
Adsorbent chamber 15 so that adsorption area increases, and improves adsorption effect；Adsorbent coherent film 18 is also immune for AIDS virus simultaneously
Adsorbent 10 provides supporting surface, prevents AIDS virus immunosorbent 10 from tenesmus precipitation occurs and influences adsorption effect.
18 lower end of adsorbent coherent film is equipped with thickening part 20.By the setting of thickening part 20, adsorbent attachment can be improved
Film 18 bears dynamics, prevents its rupture.The adding mouth 11 being connected to the second adsorbent chamber 15 is additionally provided on shell 1；Adding mouth 11
It is sequentially communicated pump 12 and regenerated liquid 13 by pipeline.
After completing primary absorption, plasma inlet can be closed first with hemostatic clamp, then the closing of barrier film 21 (for example is inserted into
In shell 1) so that disengagement chamber 5 is isolated with adsorbent chamber 6, then regenerated liquid 13 is pumped into the second adsorbent chamber 15 by pump 12, is utilized
Regenerated liquid 13 restores to dissociate in AIDS virus immunosorbent 10 and the second adsorbent chamber 15 in the first adsorbent chamber 14 AIDS of shape
The adsorption capacity of sick virus immunity adsorbent 10；Open again hemostatic clamp open plasma inlet, and by barrier film 21 open (such as from
Extraction in shell 1) so that disengagement chamber 5 is connected to adsorbent chamber 6, is repeated the above process, until reaching therapeutic dose.It needs to illustrate
, the setting structure of barrier film 21 and use the prior art with the connection relation of shell 1.
When treatment, moved along direction as shown by the arrows in Figure 4 after the output of patient's body blood, blood first passes through blood entry port
2 enter in the hollow-fiber film 8 in the disengagement chamber 5 of integral type blood plasma separation AIDS virus immuno absorbence device, and in blood
Blood plasma can pass through hollow-fiber film 8 to be separated from whole blood, and the visible component in blood in hollow-fiber film 8 is from blood
3 outflow of liquid outlet.And the blood plasma isolated first penetrate the first perforated film 9, into each independent cavity 17, and in cavity 17
The AIDS virus immunosorbent 10 that is attached on adsorbent coherent film 18 contact, the substance of curing the disease in blood plasma is by AIDS
Virus immunity adsorbent 10 is adsorbed, and blood plasma is purified.Be fully cleaned up or preliminary purification after blood plasma have hole by second again
Film 16 continues to contact, blood into the second adsorbent chamber 15 with the AIDS virus immunosorbent 10 in second adsorbent chamber 15
Slurry is further purified, and the blood plasma not being fully cleaned up in the first adsorbent chamber 14 especially can be fully cleaned up here,
The blood plasma of final purification is defeated again after being discharged from plasma outlet port 4 and converging with the visible component in the blood of 3 outflow of blood outlet
Enter patient's body.
Claims (8)
1. a kind of integral type blood plasma detaches AIDS virus immuno absorbence device, including shell (1), it is set on the shell (1) simultaneously
With its internal blood entry port (2) being connected to, blood outlet (3) and plasma outlet port (4)；It is characterized in that, the shell (1) is interior
Chamber is equipped with disengagement chamber (5) and adsorbent chamber (6)；The inner cavity both ends of the shell (1) are equipped with sealing ring (7)；In the disengagement chamber (5)
Equipped with hollow-fiber film (8)；The both ends of the hollow-fiber film (8), which plug, to be fixed on the sealing ring (7) and is connected to the blood
Liquid entrance (2) and blood outlet (3)；The disengagement chamber (5) and adsorbent chamber (6) pass through the first perforated film for only allowing blood plasma to penetrate
(9) it is connected to；AIDS virus immunosorbent (10) is equipped in the adsorbent chamber (6)；The adsorbent chamber (6) goes out with the blood plasma
Mouth (4) connection.
2. integral type blood plasma according to claim 1 detaches AIDS virus immuno absorbence device, which is characterized in that the suction
Be additionally provided in attached chamber (6) adsorbent chamber (6) is divided into the first adsorbent chamber (14) and the second adsorbent chamber (15) only permission blood plasma it is saturating
The second perforated film (16) crossed；First adsorbent chamber (14) is connected with the disengagement chamber (5) by first perforated film (9)
It is logical；It is divided into multiple independent cavitys (17), Mei Gesuo equipped with multiple non-porous films (19) in first adsorbent chamber (14)
State the adsorbent coherent film (18) that wave threadiness is equipped in cavity (17)；The adsorbent coherent film (18) is equipped with AIDS disease
Malicious immunosorbent (10)；Second adsorbent chamber (15) is connected to the plasma outlet port (4), in second adsorbent chamber (15)
AIDS virus immunosorbent (10) equipped with free shape.
3. integral type blood plasma according to claim 2 detaches AIDS virus immuno absorbence device, which is characterized in that the suction
Attached dose of coherent film (18) lower end is equipped with thickening part (20).
4. integral type blood plasma according to claim 1 detaches AIDS virus immuno absorbence device, which is characterized in that the shell
The adding mouth (11) being connected to the adsorbent chamber (6) is additionally provided on body (1)；The adding mouth (11) has been sequentially communicated by pipeline
Pump (12) and regenerated liquid (13).
5. integral type blood plasma according to claim 2 detaches AIDS virus immuno absorbence device, which is characterized in that the shell
The adding mouth (11) being connected to second adsorbent chamber (15) is additionally provided on body (1)；The adding mouth (11) by pipeline successively
It is communicated with pump (12) and regenerated liquid (13).
6. integral type blood plasma according to claim 1 or 2 detaches AIDS virus immuno absorbence device, which is characterized in that institute
The volume for stating AIDS virus immunosorbent (10) is 50~1000mL.
7. integral type blood plasma according to claim 1 or 2 detaches AIDS virus immuno absorbence device, which is characterized in that institute
The surface area for stating hollow-fiber film (8) is 0.1~2.0 ㎡.
8. integral type blood plasma protein isolate A immuno absorbence devices according to claim 4 or 5, which is characterized in that the separation
Chamber (5) is equipped with the barrier film entered in disengagement chamber (5) for stopping regenerated liquid (13) close to one end of the first perforated film (9)
(21), and barrier film (21) is flexibly connected with shell (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810141489.2A CN108653847A (en) | 2018-02-11 | 2018-02-11 | Integral type blood plasma detaches AIDS virus immuno absorbence device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810141489.2A CN108653847A (en) | 2018-02-11 | 2018-02-11 | Integral type blood plasma detaches AIDS virus immuno absorbence device |
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| Publication Number | Publication Date |
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| CN108653847A true CN108653847A (en) | 2018-10-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810141489.2A Pending CN108653847A (en) | 2018-02-11 | 2018-02-11 | Integral type blood plasma detaches AIDS virus immuno absorbence device |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012103A1 (en) * | 1998-08-31 | 2000-03-09 | Ambrus Julian L | Method for removal of hiv and other viruses from blood |
| CN101815548A (en) * | 2007-09-11 | 2010-08-25 | Bhk株式会社 | Apparatus for purifying blood |
| CN102631722A (en) * | 2012-04-26 | 2012-08-15 | 珠海健帆生物科技股份有限公司 | Blood plasma separation adsorber capable of blood purification |
-
2018
- 2018-02-11 CN CN201810141489.2A patent/CN108653847A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012103A1 (en) * | 1998-08-31 | 2000-03-09 | Ambrus Julian L | Method for removal of hiv and other viruses from blood |
| CN101815548A (en) * | 2007-09-11 | 2010-08-25 | Bhk株式会社 | Apparatus for purifying blood |
| CN102631722A (en) * | 2012-04-26 | 2012-08-15 | 珠海健帆生物科技股份有限公司 | Blood plasma separation adsorber capable of blood purification |
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Application publication date: 20181016 |