CN108647846A - A kind of Quality of Experimental Animals Control management system and management method - Google Patents
A kind of Quality of Experimental Animals Control management system and management method Download PDFInfo
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- CN108647846A CN108647846A CN201810244191.4A CN201810244191A CN108647846A CN 108647846 A CN108647846 A CN 108647846A CN 201810244191 A CN201810244191 A CN 201810244191A CN 108647846 A CN108647846 A CN 108647846A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
- G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
- G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
- G06Q10/067—Enterprise or organisation modelling
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q50/00—Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
- G06Q50/10—Services
- G06Q50/22—Social work
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L67/00—Network arrangements or protocols for supporting network services or applications
- H04L67/01—Protocols
- H04L67/02—Protocols based on web technology, e.g. hypertext transfer protocol [HTTP]
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L67/00—Network arrangements or protocols for supporting network services or applications
- H04L67/01—Protocols
- H04L67/12—Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
Abstract
The invention discloses the management method of a kind of Quality of Experimental Animals Control management system and use Quality of Experimental Animals Control management system, which includes：Information acquisition system manages the key element data information of control for linking collecting device or acquisition interface in the feeding process acquired with typing；Information management and inquiry system are counted, administrator is operated by accessing front end website, and for the information inquiry under imposing a condition, and user obtains by accessing front end website and authorizes letter for handling, analyzing typing information.Quality of Experimental Animals Control management system of the present invention and management method have carried out management, tracking and control to influencing Quality of Experimental Animals key element (disengaging personnel, feeding environment, spent material, facilities and equipment, method for breeding etc.).
Description
Technical field
The present invention relates to experimental animal information system management technical fields, and in particular to a kind of Quality of Experimental Animals control management
System and management method.
Background technology
Experimental animal is basis and the important support condition of life science, is to rise and establish along with life science
With the comprehensive cross-application subject to grow up.At present in the world 60% or more biomedical research be by experimental animal come
It carries out, Nobel's awards about physiology or medicine for having more than 70% have awarded to the research for including zoopery.Experiment
The overwhelming majority research such as subject such as physiology, Pathological Physiology, pharmacology based on sexology is completed using experimental animal
's.Have with subjects such as biology, medicine, pharmacy and very closely contact, is the base of biological medicine or even entire life science
Plinth, the modern medicine development being especially built upon on the basis of experimental medicine progress, even more be unable to do without the academic title and Bao of experimental animal
Barrier.With the continuous breakthrough of modern life science, the fast development of biological medicine pillar industry, experimental animal scientific research,
The application in the fields such as teaching, calibrating, production is more and more extensive.
Experimental animal is different from general animal, is the screening by initial stage, the animal with scientific experiment value, by tight
The control of the factors such as domestication, microbial cleaning, heredity and the feeding environment of lattice empirically requires obtained from being cultivated.It is real
Three big features should be had by testing animal at least：(1) genetic requirements, it is necessary to be artificial culture, source understands that genetic background is specific
Animal；(2) controlling extent of its microorganism and parasite is divided into four etc. by the monitoring requirement of microorganism and parasite, China
Grade, including regular grade, cleaning grade, SPF grades and sterile grade, in the overall process of experimental animal breeding, it is necessary in strict accordance with animal
Grade monitors the microorganism and parasite of its carrying, the cross contamination that especially avoid personnel from bringing；(3) application requirement, mainly
Applied to Life Science Experiment.
Experimental animal is basic tool and supporting condition important in life science subject system.Life science is tried
The primary condition for testing research institute can be summarized as tetra- fundamentals of AEIR, wherein A indicates that animal (animal), E are indicated
Equipment (equipment), I indicate that information (information), R indicate reagent (reagent).Current scientific research, configuration
High precision instrument equipment, purchase high-purity analytical reagent, acquisition up-to-date information are realized with being not difficult.Since the experimental animal of standard has
There is the features such as high to living environment dependence, causes it to be more difficult to obtain than other three conditions, become the fetters of life science
Wooden handcuff.If the genetic background of experimental animal is chaotic or health status is variant, the reactivity of body is inconsistent, causes to obtain
Experimental result is unreliable, is not easy to approve for domestic, international academic community.All results of animal are all from animal body or group
Knit the reaction to experiment stimulation.If standard is not achieved in experimental animal, the authenticity of scientific research, reliability and can be both influenced
Repeatability, and the safety of drug and biological products is even more not know where to begin with validity.
Quality of Experimental Animals control is to ensure the key means of Laboratory Animal Standardization.Quality control include personal management,
Animal quality control (environment and facility control, quality of heredity and monitoring, microorganism and parasite control and nutrition and feed
Control) etc..The overall process that the present invention is raised by the comprehensive recording laboratory animal of system, and to the real-time prison of variable factor
Control and adjustment, are realized to the standardizing of experimental animal, scientific, information-based and systematized management, are made up current experimental animal and are raised
The defect for supporting managerial confusion makes experimental animal reach long-term and keeps microorganism grade, parasite grade and specific genetic background.
When animal pollutes, processing prediction scheme is provided.
Invention content
The present invention proposes a kind of Quality of Experimental Animals Control management system and management method, to influencing Quality of Experimental Animals
Key element (disengaging personnel, feeding environment, spent material, facilities and equipment, method for breeding etc.) has carried out management, tracking and control
System.
A kind of Quality of Experimental Animals Control management system, including：
Information acquisition system is managed for linking collecting device or acquisition interface in the feeding process acquired with typing
The key element data information of control；
Information management and inquiry system are counted, administrator is by accessing front end for handling, analyzing typing information
Website is operated, and for the information inquiry under imposing a condition, and user obtains authorization message by accessing front end website.
Preferably, the information acquisition system includes；
Front end website is used for user information typing and detection data typing；
Biological information identifies control device (i.e. biological information recording device), is used for biological information typing and biological information
Identification；
Bar code generates and reads equipment, for generating and reading cage position information, shelf information and room information；
Remote camera monitoring device, for being monitored into Mobile state to entire area in facility；
Environmental monitoring and warning device, for being monitored and alarming to environment；
Facility monitors and warning device, for being monitored and alarming to facility.
The detection data includes：Equipment detects the phases such as (sterilizing equipment decontaminating apparatus etc.), water, feed, bedding and padding, Quality of Experimental Animals
Close detection data.
Coded lock realization can be used in the biological information identification.
Biological information recording device, bar code generate and read equipment, remote camera monitoring device, environmental monitoring and report
Alert, facility monitoring and warning device, for administrator, poultry raiser and user's typing corresponding information.
Preferably, the information management and inquiry system include：
Captive breeding module is used for captive breeding data management and inquiry；
Line module is used for user data management and inquiry；
Installations and facilities module is used for installations and facilities data management and inquiry；
Quality monitoring module is used for quality monitoring data management and inquiry；
Environment module is used for environmental data management and inquiry；
Image module is used for image data management and inquiry.
A kind of management method using Quality of Experimental Animals Control management system, including：
Step 1：Control device is identified by biological information, and biological information information collection, record are carried out to all personnel
Enter, according to personnel's type and information, system on human person passes in and out raising region and is allocated, and is associated with password lock device, to personnel
It is managed and controls；
Step 2：Dynamic monitoring, regulation and control are carried out to feeding environment by environmental monitoring and warning device, occurs changing or dash forward
When sending out sexual behavior part (power-off etc.) situation, is alarmed by wireless technology, manually emergency is made a response and handled；
Step 3：Dynamic monitoring is carried out to feeding facility by facility monitoring and warning device, given threshold exceeds threshold value
It is alarmed by wireless technology, human response, processing；
Step 4：Feed, drinking-water, facility and the environmental correclation indices used in periodic detection feeding process；
Step 5：Periodic detection raises animal quality of heredity, microorganism and parasite quality；
Step 6：Equipment is generated and read by bar code, and monitoring position, raising room, cage and new precession are transmitted to animal
Object generates equipment by bar code and generates corresponding bar code, and after being put between raising, room, cage, cage are scanned by bar code reading taking equipment
After the bar code information of box, system, which summarizes, generates cage box location information；Believed daily by the cage position on the bar code reading taking equipment update same day
Breath and the previous day information relatively after, form difference cage position and summarize (position difference cage, increase cage, processing cage etc.)；
Step 7：It will be Step 1: the data in two, three, four, five, six upload to central information Management System Data library；
Step 8：Administrative staff according to different querying conditions to raising and pass by raising the case where inquire,
Statistics.
Step 9：Urgent prediction scheme under abnormality, including：
When the detection datas exception such as feed, drinking-water, facility and environment, system category automatically generates different in assay intervals
Regular data summarizes, and draws the raising position (region-room-cage) of abnormal data influence, is examined labeled as animal quality emphasis
Survey region；
When animal quality detects (quality of heredity, microorganism and parasite quality) inspection item data exception, system generates the inspection
It surveys in interval, other relevant abnormalities tables of data；System forms personnel and passes in and out summary sheet, draws the faunal region of related personnel's contact
Domain-room-cage is detected the cage animal, carries out biological cleaning processing when necessary；Room related personnel is carried out
Isolation.
In step 1, all personnel includes keeper, administrative staff, testing staff, quarantine functionary, client.Owner
Member must carry out the acquisition of the information such as identity, biological information and input system.
According to personnel's type and information, system on human person can pass in and out raising region and be allocated, and be associated with coding lock system.
It is sharp that personnel into fashionable, first carry out account in biological information identification control device (i.e. biological information identification system)
Living, system side authorizes account password to open personnel assignment region/receptacle coded lock.
System passes in and out order by controlling password lock device, administrative staff.It is into region order：Rank from high to low may be used
With passage, conversely, coded lock is not opened.
In step 2, the feeding environment, including temperature, humidity, rate of ventilation, ammonia density, dust, noise, illumination
Etc. environmental parameters.
In step 3, dynamic monitoring is carried out to feeding facility and is specifically referred to feedings such as independent ventilating cage box (IVC), isolators
It supports the temperature in equipment, humidity, rate of ventilation, ammonia density, air-flow, pressure and carries out dynamic monitoring.
Compared with prior art, the invention has the advantages that：
Quality of Experimental Animals Control management system of the present invention and management method, the system are crucial to influencing Quality of Experimental Animals
Management, tracking and the control of element (disengaging personnel, feeding environment, spent material, facilities and equipment, method for breeding etc.), realize
Quality of Experimental Animals is accurately controlled in complex environment.It is not only that Quality of Experimental Animals guarantee provides a kind of efficient, stabilization
Control method and system, also provide sufficient information for quality and safe tracing.
Description of the drawings
Fig. 1 is the structural schematic diagram of Quality of Experimental Animals Control management system of the present invention；
Fig. 2 is flow diagram of the present invention using the management method of Quality of Experimental Animals Control management system.
Specific implementation mode
As shown in Figure 1, a kind of Quality of Experimental Animals Control management system, including：
Information acquisition system is managed for linking collecting device or acquisition interface in the feeding process acquired with typing
The key element data information of control；
Information management and inquiry system are counted, administrator is by accessing front end for handling, analyzing typing information
Website is operated, and for the information inquiry under imposing a condition, and user obtains by accessing front end website and authorizes letter.
Information acquisition system includes；
Front end website is used for user information typing and detection data typing；
Biological information identifies control device (i.e. biological information recording device), is used for biological information typing and biological information
Identification；
Bar code generates and reads equipment, for generating and reading cage position information, shelf information and room information；
Remote camera monitoring device, for being monitored into Mobile state to entire area in facility；
Environmental monitoring and warning device, for being monitored and alarming to environment；
Facility monitors and warning device, for being monitored and alarming to facility.
Detection data includes：Equipment detects the coherent detections such as (sterilizing equipment decontaminating apparatus etc.), water, feed, bedding and padding, Quality of Experimental Animals
Data.
Coded lock realization can be used in biological information identification.
Biological information recording device, bar code generate and read equipment, remote camera monitoring device, environmental monitoring and report
Alert, facility monitoring and warning device, for administrator, poultry raiser and user's typing corresponding information.
Information management and inquiry system include：
Captive breeding module is used for captive breeding data management and inquiry；
Line module is used for user data management and inquiry；
Installations and facilities module is used for installations and facilities data management and inquiry；
Quality monitoring module is used for quality monitoring data management and inquiry；
Environment module is used for environmental data management and inquiry；
Image module is used for image data management and inquiry.
The present invention uses the management method of Quality of Experimental Animals Control management system, and example is raised with certain colleges and universities.Purchase institute
Hardware is needed, including is coupled by Fig. 1 related systems, is come into operation after debugging, detecting.It is moved from there is the experiment of the production quality certification
Transport is to raising unit after object production unit orders animal, into carrying out follow-up work between raising.
The first step, raising unit is newly-built, reconstruction or the receptacle newly introduced after deactivating or laboratory, purchase related facility,
Equipment, including feeding facility, air cleaning facility, air moving equipment, heating/refrigeration equipment, pass-through box, sterilizing equipment decontaminating apparatus, cleaning
Equipment, environment/facility monitoring device etc..After equipment is coupled central management control system, by commissioning device correlation function, fortune
After row and testing result meet relevant national standard and regulation, come into operation.Central management control system carries out facility, equipment
Responsible person is associated with；
Second step, acquisition, upload relevant information, including personal information (biological information, identity information, fund information etc.),
Detection information (Disinfection Effect detection, water/feed/bedding and padding detection, animal quality detection, environment measuring), is set environmental monitoring information
Apply monitoring information, monitoring of equipment information, image monitoring information；
Third walk, newly into animal according to animal ordering information (tutor and experimenter) and animal information (source, kind,
Strain, gender etc.) archives are generated, it forms bar code and is placed on outside rearging cage.The bar code is the unique mark of current animal, for follow-up
All raising information traces.Poultry raiser utilizes scanning recognition equipment according to certain rule scanning room, cage and raising daily
Cage bar code, generates rearging cage location information, and situation is raised in synthesis region；
4th step belongs to planning cultured space by animal, and the animal of same tutor is positioned in a room.Pass through biology
Information identification system and coded lock, controllers only enter system authorization region.Avoid the animal quality caused by personnel's confusion
Decline.Room and camera shooting information are opened by personnel's coded lock, record personnel pass in and out situation；
5th step, environment, monitoring of equipment equipment and picture pick-up device upload dynamic data automatically；Environment and device data are abnormal
When, central control management system restores normal value by regulating and controlling relevant device, can not such as restore, and starts telephone alerting system notice
Facilities and equipment responsible person；
6th step, the emergent management of animal anomaly state, including：
(1) in cage when animal state exception (reproducing cage divides cage, animal bite, animal dead etc.), poultry raiser issues raising
Animal anomaly Status Type in cage location and cage, central control management system inform experimenter interior place for 24 hours by mailing system
Reason, it is untreated to notify administrator.
(2) when microorganism and parasitic infection occurs in animal, which is moved into dirty district and carries out biological cleaning processing；
It inquires in central control management system, the animal of room disengaging human contact is detected, and carries out at biological cleaning when necessary
Reason；To the room, related personnel is isolated.
7th step, center management system handle the information of information acquisition system, are analyzed, to passing in and out personnel setting pipe
Manage permission, search access right and the region that comes in and goes out.All personnel is imposed a condition according to respective permission by information query system
Under information inquiry.
Claims (7)
1. a kind of Quality of Experimental Animals Control management system, which is characterized in that including：
Information acquisition system manages control for linking collecting device or acquisition interface in the feeding process acquired with typing
Key element data information；
Information management and inquiry system are counted, administrator is by accessing front end website for handling, analyzing typing information
It is operated, and for the information inquiry under imposing a condition, user obtains authorization message by accessing front end website.
2. Quality of Experimental Animals Control management system according to claim 1, which is characterized in that the information collection system
System includes；
Front end website is used for user information typing and detection data typing；
Biological information identifies control device, is identified for biological information typing and biological information；
Bar code generates and reads equipment, for generating and reading cage position information, shelf information and room information；
Remote camera monitoring device, for being monitored into Mobile state to entire area in facility；
Environmental monitoring and warning device, for being monitored and alarming to environment；
Facility monitors and warning device, for being monitored and alarming to facility.
3. Quality of Experimental Animals Control management system according to claim 1, which is characterized in that the information management and
Inquiry system includes：
Captive breeding module is used for captive breeding data management and inquiry；
Line module is used for user data management and inquiry；
Installations and facilities module is used for installations and facilities data management and inquiry；
Quality monitoring module is used for quality monitoring data management and inquiry；
Environment module is used for environmental data management and inquiry；
Image module is used for image data management and inquiry.
4. a kind of management method using claims 1 to 3 any one of them Quality of Experimental Animals Control management system, special
Sign is, including：
Step 1：Control device is identified by biological information, and biological information information collection, typing, root are carried out to all personnel
According to personnel's type and information, system on human person passes in and out raising region and is allocated, and is associated with password lock device, and pipe is carried out to personnel
Reason and control；
Step 2：Dynamic monitoring, regulation and control are carried out to feeding environment by environmental monitoring and warning device, occur changing or sudden
It when situation, is alarmed by wireless technology, manually emergency is made a response and handled；
Step 3：Dynamic monitoring is carried out to feeding facility by facility monitoring and warning device, given threshold passes through beyond threshold value
Wireless technology is alarmed, human response, processing；
Step 4：Feed, drinking-water, facility and the environmental correclation indices used in periodic detection feeding process；
Step 5：Periodic detection raises animal quality of heredity, microorganism and parasite quality；
Step 6：Equipment is generated and read by bar code, monitoring position is transmitted to animal, raise room, cage and newly lead into animal
It crosses bar code and generates equipment and generate corresponding bar code, after being put between raising, room, cage, cage box are scanned by bar code reading taking equipment
After bar code information, system, which summarizes, generates cage box location information；Daily by the cage position information on the bar code reading taking equipment update same day, and
The previous day information relatively after, form difference cage position and summarize；
Step 7：It will be Step 1: the data in two, three, four, five, six upload to central information Management System Data library；
Step 8：Administrative staff are according to different querying conditions to raising and the case where passing by raising inquires, counts.
Step 9：Urgent prediction scheme under abnormality, including：
When the detection datas exception such as feed, drinking-water, facility and environment, system category automatically generates the abnormal number in assay intervals
According to summarizing, and the raising position of abnormal data influence is drawn, is labeled as animal quality focus detection area domain；
When animal quality detection inspection item data exception, system generates in the test interval, other relevant abnormalities tables of data；System
Formation personnel pass in and out summary sheet, draw faunal district-room-cage of related personnel's contact, are detected to the cage animal,
Biological cleaning processing is carried out when necessary；To the room, related personnel is isolated.
5. management method according to claim 4, which is characterized in that in step 1, personnel believe first in biology into fashionable
Breath identification control device carries out Account activation, and system side authorizes account password to open personnel assignment region/receptacle coded lock.
6. management method according to claim 4, which is characterized in that in step 2, the feeding environment, including temperature
Degree, humidity, rate of ventilation, ammonia density, dust, noise, lighting environment parameter.
7. management method according to claim 4, which is characterized in that in step 3, dynamic monitoring is carried out to feeding facility
It specifically refers to carry out dynamic monitoring to temperature, humidity, rate of ventilation, ammonia density, air-flow, the pressure in feeding facility.
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| CN201810244191.4A CN108647846A (en) | 2018-03-23 | 2018-03-23 | A kind of Quality of Experimental Animals Control management system and management method |
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| CN201810244191.4A CN108647846A (en) | 2018-03-23 | 2018-03-23 | A kind of Quality of Experimental Animals Control management system and management method |
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| CN110050723A (en) * | 2019-06-06 | 2019-07-26 | 北京大学第一医院 | A kind of method and system of online experiment animal monitoring and early warning |
| CN112189589A (en) * | 2020-10-15 | 2021-01-08 | 武汉市万千佳兴生物科技有限公司 | Intelligent system capable of displaying experimental rabbit breeding information in real time |
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