CN108642359A - A kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity and preparation method thereof - Google Patents
A kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity and preparation method thereof Download PDFInfo
- Publication number
- CN108642359A CN108642359A CN201810879128.8A CN201810879128A CN108642359A CN 108642359 A CN108642359 A CN 108642359A CN 201810879128 A CN201810879128 A CN 201810879128A CN 108642359 A CN108642359 A CN 108642359A
- Authority
- CN
- China
- Prior art keywords
- alloy
- medical
- high intensity
- materials
- ingot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/02—Making non-ferrous alloys by melting
- C22C1/03—Making non-ferrous alloys by melting using master alloys
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of high intensity degradable biological medical Mg Zn Zr Fe alloy materials and preparation method thereof.The mass percent of the magnesium alloy each component is：Zn5.0~6.0%, Zr0.5~1.0%, Fe0.01~0.09%, remaining is Mg and its inevitable impurity.Specific preparation method includes melting, casting Homogenization Treatments, hot extrusion and artificial aging processing, obtains meeting biological medical magnesium alloy plate, stick, wire rod under biological fluid environment is on active service.The present invention is added to harmless alloying element in the magnesium alloy, and to human body without any toxicity after alloy degradation in vivo, excellent in mechanical performance has good mechanical property and processing performance, has with corrosion rate appropriate.The high intensity degradable biological medical Mg Zn Zr Fe alloy materials of the present invention, tensile strength >=360MPa, yield strength >=320MPa, suitable for preparing the medical materials such as nail.
Description
Technical field
The invention belongs to biomedical complex magnesium alloy field, more particularly to a kind of organism absorbable Mg-Zn-
Zr-Fe complex magnesium alloy materials.
Background technology
Currently, it includes mainly stainless steel, cochrome, titanium alloy that it is metal material embedded, which to be widely used in clinical biology,.
The equal non-degradable of these metal materials, implantation material must be taken out after tissue functional rehabilitation by second operation.Cause
This, degradable metal material future has preferable development prospect in biomedical materials field.What is be currently in development can
Degradation metal material has：Magnesium alloy, ferroalloy and kirsite.Magnesium alloy is because with good biocompatibility, mechanical compatibility
The advantages that, it is increasingly becoming the research hotspot of biomedical materials field in recent years.The advantages of magnesium, is embodied in：(1) it is people
A kind of mineral matter element necessary to body, can also be discharged when excessive by urine, because without causing toxic reaction；(2) Young
Modulus is close with people's bone, and stress-shielding effect can be effectively relieved in the application of correlation implantation material.
In recent years, researcher develops a series of degradable magnesium alloys, such as patent of invention《Organism absorbable Mg-
Zn-Fe ternary magnesium alloy materials》(the patent No.：200510111793.5), patent of invention《Organism absorbable Mg-Zn-
Ca-Fe complex magnesium alloy materials》(the patent No.：200510111792.0), patent of invention《Bio-medical Mg-Zn-Zr-Mn magnesium closes
Gold and preparation method thereof》(application number：201510870718.0), patent of invention《Biological medical degradable Mg-Zn-Zr-Sc alloys
And preparation method thereof》(application number：201410101431.7), patent of invention《Biomedical degradable corrosion-resistant Mg-Zn-Zr is closed
Gold and preparation method》(application number：201310275808.6).Above-mentioned patent by Mg-Zn systems alloys add Mn, Sc, Fe,
The elements such as Ca, Zr crystal grain thinning and the corrosion resistance for improving alloy.However, above-mentioned strength of alloy generally in 300MPa hereinafter,
And it is only used for making the longer medical instrument of Implantation Time.It cannot be satisfied convalescence shorter injury gained in sports treatment and rehabilitation
Demand, this requires material not only to meet good biocompatibility, while also to have faster degradation rate and higher
Tensile strength and yield strength.
Industrially, due to higher intensity, ZK60 systems magnesium alloy (Mg- (5.5~6.0) Zn- (0.3~0.9) Zr,
Wt% application) is relatively broad.But some researches show that excessively high Zn (more than 8%) content can cause dredging for Mg alloy surface film
It loosens and falls, reduce the corrosion resistance of magnesium alloy；And the elongation percentage of magnesium alloy can also be reduced with the increase of Zn contents.Therefore, it moulds
The ZK60 alloys that property is relatively low, corrosion resistance is poor, are restricted in the application of biomedical sector.
On the other hand, it is that corrosion rate is too fast that magnesium alloy biomaterials application, which is existing main problem, especially impurity
Content is to influence one of the most important factor of corrosion stability of magnesium alloy, especially harmful element, such as the content of Fe, Ni, Cu and Co, is needed
The content of these harmful elements (the molten limit of highest of 3 kinds of elements of Fe, Cu and Ni in Mg below tolerable limit in control alloy
Amount is respectively 170 × 10-6, 1000 × 10-6, 5 × 10-6) to effectively improve the corrosion resisting property of alloy.
Invention content
Insufficient existing for existing biological medical magnesium alloy in order to overcome, the present invention provides one kind and can be applied to organism plant
Enter the fast degradation Mg-Zn-Zr-Fe alloys and preparation method thereof of the high intensity of material.The strength of alloy and yield strength
It is higher, and there is good biocompatibility and fast degradation performance, it can be used as injury gained in sports treatment and rehabilitation interposers
Tool.
To achieve the goals above, the present invention adopts the following technical scheme that：
There is provided a kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity for an object of the present invention
Material, is made of the element of following weight percent：Zn 5.0~6.0%, Zr 0.5~1.0%, Fe 0.01~0.09%, Al
＜ 0.01%, Ni ＜ 0.005%, Cu ＜ 0.005%.Remaining is Mg and its inevitable impurity.
The application research is found：In Mg-Zn-Zr alloys, the Fe of 0.01-0.09% is added, since Fe and Mg will not shape
At interphase, Fe and Zr plays the role of equiax crystal simultaneously in casting process, therefore, can refine crystallite dimension, change
It has been apt to microstructure segregation, has improved the corrosion resistance of magnesium alloy.But since the increase of Fe contents can have an adverse effect to the corrosion of Mg, it is
This, the application improves the content of zinc in magnesium alloy, finds：When Zn contents are 5.0~6.0%, it can both be effectively improved improvement
The performance of skin covering of the surface, and the safe level of objectionable impurities Fe, Ni, Cu in the alloy can be improved, the influence that Fe corrodes Mg is reduced,
To obtain with excellent tensile strength, yield strength and suitable degradation speed magnesium alloy.
In some embodiments, tensile strength >=360MPa of the alloy material, yield strength >=320MPa, elongation percentage
>=14%；In 37 DEG C of Hank ' s simulated body fluids, corrosion rate≤0.28mgcm-2·day-1。
In some embodiments, impurity element mass percent is：Al ＜ 0.01%, Ni ＜ 0.005%, Cu ＜
0.005%.
The present invention also provides a kind of preparation sides of the fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity
Method, including：
Magnesium ingot, zinc ingot metal, iron, Mg-30%Zr intermediate alloys are subjected to melting, pour into ingot casting；
Above-mentioned ingot casting is subjected to Homogenization Treatments, and is squeezed into plate, stick or wire rod；
By plate, stick, the wire rod after extruding carry out artificial aging processing, it is air-cooled to get.
In some embodiments, described " melting pours into ingot casting " the specific steps are：By magnesium ingot, zinc ingot metal, iron, Mg-
30%Zr intermediate alloys keep the temperature 40~60min at 780~800 DEG C, and 5~10min is stirred after above-mentioned raw materials all melt, is then dropped
Temperature is warming up to 750~780 DEG C of 30~40min of standing, is poured at 710-730 DEG C to 730~750 DEG C of 20~30min of refining after refining
Form ingot casting.
In some embodiments, the condition of the Homogenization Treatments is that Homogenization Treatments are carried out at 400~420 DEG C, is protected
Warm time 16-18h, then in 50~60 DEG C of water coolings.
Mg-30%Zr intermediate alloys in the application can refer to paper《Rare metal and hard alloy》,2006,34(1):
Prepared by the method for 30-32 (Liu Jiaxiang, Yang Qingshan, Liu Shuping, Chen Weiping, He Bining), or use commercial product.
In some embodiments, the actual conditions of the extruding are：250~300 DEG C of temperature of extruding, extrusion speed 0.1~
5mm/s。
In some embodiments, the condition of the artificial aging processing is to keep the temperature 24~36h at 150~160 DEG C, empty
It is cold.
The present invention also provides the fast degradation bio-medical Mg-Zn-Zr-Fe of high intensity prepared by any above-mentioned method
Alloy material.
The present invention also provides any above-mentioned Mg-Zn-Zr-Fe alloy materials to prepare for injury gained in sports treatment and health
Application in multiple tissue engineering bracket material.
Beneficial effects of the present invention
(1) Mg-Zn-Zr-Fe alloys of the present invention select Mg, Zn, Zr, Fe with good biocompatibility, close
The degradation of gold will not generate harm to organism.
(2) Mg-Zn-Zr-Fe alloys of the present invention and preparation method thereof pass through the addition of appropriate Fe elements, refinement
Tissue, improves component segregation, thus improves intensity so that material has excellent tensile strength, yield strength and drop
Solve speed.This is particularly suitable for the preparation of the implantation instrument of convalescence shorter injury gained in sports treatment and rehabilitation；
On the other hand, the application is also additionally added the Zn of 5-6%, while improving the performance of skin covering of the surface, improves Fe and is closing
Safe level in gold.
(3) preparation method of Mg-Zn-Zr-Fe alloys of the present invention big rule at low cost, simple for process, easy to implement
Mold technique produces.
(4) crystallite dimension of the application squeeze wood is less than 10 μm, and crystallite dimension is small, and microstructure segregation is small, mechanics and corrosion resistance
It can be excellent.
Description of the drawings
The accompanying drawings which form a part of this application are used for providing further understanding of the present application, and the application's shows
Meaning property embodiment and its explanation do not constitute the improper restriction to the application for explaining the application.
Fig. 1 is Mg-Zn-Zr-Fe extruded bars alloy microscopic structures.
Specific implementation mode
It is noted that following detailed description is all illustrative, it is intended to provide further instruction to the application.Unless another
It indicates, all technical and scientific terms used herein has usual with the application person of an ordinary skill in the technical field
The identical meanings of understanding.
The present invention relates to a kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloys of high intensity, the quality of alloying element
Percentage is：Zn5.0~6.0%, Zr0.5~1.0%, Fe0.01~0.09%, remaining is Mg and its inevitable impurity.
In Mg-Zn-Zr-Fe alloys of the present invention, impurity element mass percent is：Al ＜ 0.01%, Ni ＜
0.005%, Cu ＜ 0.005%.
A kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy preparation methods of high intensity of the present invention, including it is following
Step：
(1) weigh according to the ratio raw material, above-mentioned raw materials using high-purity magnesium ingot, high-purity zinc ingot metal, high purity iron, Mg-30%Zr among
Alloy carries out melting to above-mentioned raw materials by vaccum sensitive stove under argon gas protective condition, at 780~800 DEG C keep the temperature 40~
60min stirs 5~10min after above-mentioned raw materials all melt, and 730~750 DEG C of 20~30min of refining is then cooled to, after refining
750~780 DEG C of 30~40min of standing are warming up to, ingot casting is poured at 710-730 DEG C；
(2) above-mentioned ingot casting is subjected to Homogenization Treatments, soaking time 16-18h, 50~60 DEG C of water at 400~420 DEG C
It is cold；
(3) by the alloy after Homogenization Treatments by extruder squeeze 250~300 DEG C of temperature, extrusion speed 0.1~
Plate, stick, wire rod are squeezed under conditions of 5mm/s；
(4) plate, stick, the wire rod after extruding are subjected to artificial aging processing at 150~160 DEG C, soaking time 24~
36h, it is air-cooled.
The extrusion ratio of the extruder is selected according to the size of material requested.
Argon gas at least prepurging 2 times is used before melting.
Mg >=99.99% in high-purity magnesium ingot, remaining is impurity；Zn >=99.99% in high-purity zinc ingot metal, remaining is impurity；It is high
Fe >=99.98% in straight iron powder, remaining is impurity；Zr mass percents are 29-31%, impurity in Mg-30%Zr intermediate alloys
Mass percent ＜ 0.005%, remaining is Mg.
Embodiment 1
The mass percent of Mg-Zn-Zr-Fe alloying elements is：Zn is 5.8%, Zr 0.65%, Fe 0.03%, Al
For 0.005%, Ni 0.004%, Cu 0.004%, remaining is Mg.
Raw material is：The Mg ingots of purity 99.995%, the Zn ingots of purity 99.993%, purity 99.987% Fe ingots and
The Mg-Zr intermediate alloys (impurity mass percent 0.004%) that the mass percent of Zr is 29.8%.
It weighs according to the ratio raw material, melting is carried out under argon gas protective condition to above-mentioned raw materials by vaccum sensitive stove, 800
DEG C heat preservation 60min, stir 5min after above-mentioned raw materials all melts, be then cooled to 730 DEG C refine 25min, be warming up to after refining
760 DEG C of standing 30min, ingot casting is poured at 710 DEG C；
Above-mentioned ingot casting is subjected to Homogenization Treatments, soaking time 16h, 60 DEG C of water coolings at 420 DEG C；
By the alloy after Homogenization Treatments by extruder under conditions of squeezing 250 DEG C of temperature, extrusion speed 0.1mm/s
It is squeezed into stick, extrusion ratio 30；
Plate, stick, wire rod after extruding is subjected to artificial aging processing at 150 DEG C, soaking time is for 24 hours, air-cooled.
The bar microscopic structure of the alloy is as shown in Figure 1, its average grain size is about 7 μm；；The room temperature tensile of the alloy
Intensity is 368MPa, yield strength 335MPa, elongation percentage 14%.；In 37 DEG C of Hank ' s simulated body fluids (ingredient is shown in Table 1)
In, corrosion rate 0.26mgcm-2·day-1, forms of corrosion is homogeneous corrosion.
1 experiment Hank ' s simulated body fluids chemical compositions (g/L) of table
Embodiment 2
The mass percent of Mg-Zn-Zr-Fe alloying elements is：Zn is 5.6%, Zr 0.74%, Fe 0.05%, Al
For 0.004%, Ni 0.003%, Cu 0.004%, remaining is Mg.
Raw material is：The Mg ingots of purity 99.995%, the Zn ingots of purity 99.993%, purity 99.987% Fe ingots and
The Mg-Zr intermediate alloys (impurity mass percent 0.004%) that the mass percent of Zr is 30%.
It weighs according to the ratio raw material, melting is carried out under argon gas protective condition to above-mentioned raw materials by vaccum sensitive stove, 790
DEG C heat preservation 50min, stir 10min after above-mentioned raw materials all melts, be then cooled to 750 DEG C refine 30min, be warming up to after refining
780 DEG C of standing 40min, ingot casting is poured at 720 DEG C；
Above-mentioned ingot casting is subjected to Homogenization Treatments, soaking time 18h, 55 DEG C of water coolings at 410 DEG C；
By the alloy after Homogenization Treatments by extruder under conditions of squeezing 280 DEG C of temperature, extrusion speed 0.3mm/s
It is squeezed into stick, extrusion ratio 20；
Plate, stick, wire rod after extruding is subjected to artificial aging processing at 155 DEG C, soaking time 30h is air-cooled.
The average grain size of the bar of the alloy is about 6 μm；The room temperature tensile intensity of the alloy is 372MPa, and surrender is strong
Degree is 338MPa, elongation percentage 15%.；In 37 DEG C of Hank ' s simulated body fluids (ingredient is shown in Table 1), corrosion rate is
0.28mg·cm-2·day-1, forms of corrosion is homogeneous corrosion.
The foregoing is merely the preferred embodiments of the application, are not intended to limit this application, for the skill of this field
For art personnel, the application can have various modifications and variations.Within the spirit and principles of this application, any made by repair
Change, equivalent replacement, improvement etc., should be included within the protection domain of the application.
Claims (10)
1. a kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity, which is characterized in that by following weight hundred
Divide the element composition of ratio：Zn 5.0~6.0%, Zr 0.5~1.0%, Fe 0.01~0.09%, Al ＜ 0.01%, Ni ＜
0.005%, Cu ＜ 0.005%.Remaining is Mg and its inevitable impurity.
2. alloy material as described in claim 1, which is characterized in that tensile strength >=360MPa of the alloy material is bent
Take intensity >=320MPa, elongation percentage >=14%；In 37 DEG C of Hank ' s simulated body fluids, corrosion rate≤0.28mgcm-2·
day-1。
3. alloy material as described in claim 1, which is characterized in that impurity element mass percent is：Al ＜ 0.01%, Ni
＜ 0.005%, Cu ＜ 0.005%.
4. a kind of preparation method of the fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity, which is characterized in that packet
It includes：
Magnesium ingot, zinc ingot metal, iron, Mg-30%Zr intermediate alloys are subjected to melting, pour into ingot casting；
Above-mentioned ingot casting is subjected to Homogenization Treatments, and is squeezed into plate, stick or wire rod；
By plate, stick, the wire rod after extruding carry out artificial aging processing, it is air-cooled to get.
5. method as claimed in claim 4, which is characterized in that " melting pours into ingot casting " the specific steps are：By magnesium
Ingot, zinc ingot metal, iron, Mg-30%Zr intermediate alloys keep the temperature 40~60min at 780~800 DEG C, and 5 are stirred after above-mentioned raw materials all melt
~10min, be then cooled to 730~750 DEG C refining 20~30min, be warming up to after refining 750~780 DEG C stand 30~
40min pours into ingot casting at 710-730 DEG C.
6. method as claimed in claim 4, which is characterized in that the condition of the Homogenization Treatments be at 400~420 DEG C into
Row Homogenization Treatments, soaking time 16-18h, then in 50~60 DEG C of water coolings.
7. method as claimed in claim 4, which is characterized in that the actual conditions of the extruding are：Squeeze temperature 250~300
DEG C, 0.1~5mm/s of extrusion speed.
8. method as claimed in claim 4, which is characterized in that the condition of the artificial aging processing is at 150~160 DEG C
Under, 24~36h is kept the temperature, it is air-cooled.
9. the fast degradation bio-medical Mg-Zn-Zr-Fe of high intensity prepared by claim 4-8 any one of them methods is closed
Golden material.
10. claim 1-3,9 any one of them Mg-Zn-Zr-Fe alloy materials are being prepared for injury gained in sports treatment and health
Application in multiple tissue engineering bracket material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810879128.8A CN108642359B (en) | 2018-08-03 | 2018-08-03 | High-strength rapid-degradation biomedical Mg-Zn-Zr-Fe alloy material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810879128.8A CN108642359B (en) | 2018-08-03 | 2018-08-03 | High-strength rapid-degradation biomedical Mg-Zn-Zr-Fe alloy material and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108642359A true CN108642359A (en) | 2018-10-12 |
| CN108642359B CN108642359B (en) | 2020-03-17 |
Family
ID=63760783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810879128.8A Active CN108642359B (en) | 2018-08-03 | 2018-08-03 | High-strength rapid-degradation biomedical Mg-Zn-Zr-Fe alloy material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108642359B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113061790A (en) * | 2021-03-16 | 2021-07-02 | 西安交通大学 | Mg-Zn-Ni ternary magnesium alloy material with wide corrosion rate range |
| CN114921700A (en) * | 2022-05-25 | 2022-08-19 | 中南大学 | Biodegradable Mg-Zn-Ca-Re alloy |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101629260A (en) * | 2008-07-18 | 2010-01-20 | 中国科学院金属研究所 | Medical absorbable Mg-Zn-Mn-Ca magnesium alloy |
| JP2014534338A (en) * | 2011-10-06 | 2014-12-18 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｐｉｔｔｓｂｕｒｇｈ Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ | Biodegradable metal alloy |
| CN105256213A (en) * | 2015-12-01 | 2016-01-20 | 天津东义镁制品股份有限公司 | Bio-medical Mg-Zn-Zr-Mn magnesium alloy and preparation method thereof |
| CN107541632A (en) * | 2017-08-28 | 2018-01-05 | 北京科技大学 | A kind of bio-medical Mg Zn Zr magnesium alloys and preparation method thereof |
| CN107557632A (en) * | 2017-08-16 | 2018-01-09 | 北京科技大学 | A kind of degradable biological medical Mg Zn Zr Nd alloy materials and preparation method thereof |
| US20180100219A1 (en) * | 2014-04-03 | 2018-04-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biodegradable metal alloys |
-
2018
- 2018-08-03 CN CN201810879128.8A patent/CN108642359B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101629260A (en) * | 2008-07-18 | 2010-01-20 | 中国科学院金属研究所 | Medical absorbable Mg-Zn-Mn-Ca magnesium alloy |
| JP2014534338A (en) * | 2011-10-06 | 2014-12-18 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｐｉｔｔｓｂｕｒｇｈ Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ | Biodegradable metal alloy |
| US20180100219A1 (en) * | 2014-04-03 | 2018-04-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biodegradable metal alloys |
| CN105256213A (en) * | 2015-12-01 | 2016-01-20 | 天津东义镁制品股份有限公司 | Bio-medical Mg-Zn-Zr-Mn magnesium alloy and preparation method thereof |
| CN107557632A (en) * | 2017-08-16 | 2018-01-09 | 北京科技大学 | A kind of degradable biological medical Mg Zn Zr Nd alloy materials and preparation method thereof |
| CN107541632A (en) * | 2017-08-28 | 2018-01-05 | 北京科技大学 | A kind of bio-medical Mg Zn Zr magnesium alloys and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 唐代明等: "《金属材料学》", 30 June 2014, 西南交通大学出版社 * |
| 唐靖林等: "《铸造非铁合金及其熔炼》", 31 August 2007, 中国水利水电出版社 * |
| 张宝昌等: "《有色金属及其热处理》", 30 October 1993, 西北工业大学出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113061790A (en) * | 2021-03-16 | 2021-07-02 | 西安交通大学 | Mg-Zn-Ni ternary magnesium alloy material with wide corrosion rate range |
| CN113061790B (en) * | 2021-03-16 | 2022-05-06 | 西安交通大学 | Mg-Zn-Ni ternary magnesium alloy material with wide corrosion rate range |
| CN114921700A (en) * | 2022-05-25 | 2022-08-19 | 中南大学 | Biodegradable Mg-Zn-Ca-Re alloy |
| CN114921700B (en) * | 2022-05-25 | 2023-09-26 | 中南大学 | Biodegradable Mg-Zn-Ca-Re alloy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108642359B (en) | 2020-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2764130B1 (en) | Biodegradable metal alloys | |
| CN109097629B (en) | Biodegradable Zn-Mo series zinc alloy and preparation method thereof | |
| US10604827B2 (en) | Biodegradable metal alloys | |
| CN108588484A (en) | High-strength high-plastic biodegradable Zn-Mn-Mg systems kirsite of one kind and preparation method thereof | |
| CN106702212A (en) | Medical degradable Zn-Cu-X alloy material and preparation method thereof | |
| CN107557632A (en) | A kind of degradable biological medical Mg Zn Zr Nd alloy materials and preparation method thereof | |
| CN103184379B (en) | Biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and preparation method thereof | |
| CN107557633B (en) | A kind of microalloying medical degradable magnesium alloy and preparation method thereof | |
| CN109112377B (en) | Corrosion-resistant biomedical magnesium alloy and preparation method and application thereof | |
| CN107435113B (en) | A kind of tough corrosion-resistant orthopaedics magnesium alloy of height degradable in vivo and preparation method thereof | |
| CN104630587A (en) | Degradable magnesium alloy plate and bar for fracture internal fixation and preparation methods thereof | |
| CN108203778B (en) | Zr-based biomedical alloy and preparation method thereof | |
| CN108950336A (en) | A kind of high-ductility degradable biological medical Mg-Zn-Zr-Ca-Fe alloy material and preparation method thereof | |
| CN107236886A (en) | A kind of polynary Mg Zn Y Ca Zr alloys of medical degradable high-strength anticorrosion and preparation method thereof | |
| CN104862566A (en) | High-strength high-plasticity medical magnesium alloy, and preparation method and applications thereof | |
| CN108754232A (en) | High-strength high-plastic biodegradable Zn-Mn-Li systems kirsite of one kind and application thereof | |
| CN108425051A (en) | A kind of bio-medical Mg-Sn-Zn-Ca magnesium alloys and preparation method thereof | |
| CN106244882A (en) | Mg Gd Zn (Ca) medical magnesium alloy with LPSO structure and preparation method thereof | |
| CN108677074A (en) | A kind of medical degradable corrosion-resistant magnesium alloy bracket and preparation method thereof of implantation heart | |
| CN109966568A (en) | A kind of Zn-Ge-X ternary bio-medical material and preparation method thereof | |
| CN108277407A (en) | A kind of intravascular stent degradable corrosion-resistant magnesium alloy and preparation method thereof | |
| CN105803282B (en) | A kind of single-phase Multielement rare-earth magnesium alloy biodegradation material and preparation method thereof | |
| CN111733353B (en) | Absorbable bone fixation medical Mg-Ag-Ca alloy and preparation method thereof | |
| CN108642359A (en) | A kind of fast degradation bio-medical Mg-Zn-Zr-Fe alloy materials of high intensity and preparation method thereof | |
| CN112472868A (en) | Degradable Mg-Nd-Zn-Sc biomedical magnesium alloy and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |