CN108628001B - It is a kind of for collecting the contact lens of tear protein - Google Patents

It is a kind of for collecting the contact lens of tear protein Download PDF

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Publication number
CN108628001B
CN108628001B CN201810456469.4A CN201810456469A CN108628001B CN 108628001 B CN108628001 B CN 108628001B CN 201810456469 A CN201810456469 A CN 201810456469A CN 108628001 B CN108628001 B CN 108628001B
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China
Prior art keywords
collecting
contact lens
tear
pump chamber
pump
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CN201810456469.4A
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Chinese (zh)
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CN108628001A (en
Inventor
弥胜利
杨建�
杨星
赵港南
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Shenzhen Graduate School Tsinghua University
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Shenzhen Graduate School Tsinghua University
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    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/047—Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0067—Tear or lachrymal fluid

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Reciprocating Pumps (AREA)

Abstract

The invention discloses a kind of for collecting the contact lens of tear protein, including with the internal layer of Corneal Contact and the outer layer contacted with eyelid, the runner for collecting tear is provided on the internal layer, pump chamber and at least one collecting protein room with pump intake and pump discharge, the pump chamber is connected in series with the collecting protein room by the runner, it is provided with and is corresponded in the pumping diaphragm of the protrusion of the pump chamber on the outer layer, the pump chamber and the pumping diaphragm form scalable Micropump, power is obtained using the movement of wearer's blink, pressure difference is generated in the pump chamber, tear is set to be pumped into the collecting protein room.The contact lens collects albumen using the blink movement of wearer itself, overcomes the defect that present stimulus method is collected in vitro.

Description

It is a kind of for collecting the contact lens of tear protein
Technical field
The present invention relates to a kind of for collecting the contact lens of tear protein.
Background technique
Contain multiple protein in tear, studies have shown that some diseases will affect the secretion of tear protein.Pass through To the reliable analysis of tear protein concentration, foundation can be provided for diagnosis, the treatment of related disease.Albumen is expressed in tear Amount is few, and in order to obtain enough tears, widespread practice is artificial stimulation at present, is collected by device outside.Side now The tear that formula is collected, wherein the ingredient of albumen is diluted, and cannot provide accurate foundation for detection.
Summary of the invention
It is a kind of for collecting the angle of tear protein it is a primary object of the present invention to overcome the deficiencies of the prior art and provide Film contact lense.
To achieve the above object, the invention adopts the following technical scheme:
It is a kind of for collecting the contact lens of tear protein, including being contacted with the internal layer of Corneal Contact and with eyelid Outer layer, be provided with the runner for collecting tear, the pump chamber with pump intake and pump discharge and at least one on the internal layer A collecting protein room, the pump chamber are connected in series with the collecting protein room by the runner, are provided with one on the outer layer One corresponds to the pumping diaphragm of the protrusion of the pump chamber, and the pump chamber and the pumping diaphragm form scalable Micropump, utilizes wearer's blink Movement obtains power, generates pressure difference in the pump chamber, tear is made to be pumped into the collecting protein room.
Further:
The collecting protein room has outlet, by runner to outside drain tear.
The pump chamber of multiple parallel connections is provided on the internal layer for collecting tear, it is preferable that be additionally provided with multiple parallel connections Pump chamber is used for outside drain tear.
The pump intake of pump chamber at tear collection extends to the edge of the contact lens, it is preferable that is located at tear The pump discharge of pump chamber at liquid discharge extends to the edge of the contact lens.
The internal layer is identical as the outer layer shape and matches with cornea shape, and it includes described that the internal layer, which has multiple, The micro-structure of runner, the pump chamber and the collecting protein room, the micro-structure are centrosymmetric distribution on the inner layer.
There are two the micro-structure for the distribution that is centrosymmetric, each micro-structure has to be used the internal layer tool respectively In more than two collecting protein rooms collecting different albumen and being connected in series by runner.
The internal layer is provided with pump chamber on the runner between concatenated collecting protein room, the outer layer corresponds to described Pump chamber is provided with pumping diaphragm.
The bottom surface of the collecting protein room has specific surface area of the profile to rise and fall to increase.
Pass through surface chemical modification in the collecting protein room, is grafted the targeted molecular of albumen to be collected.
The pump chamber and the pumping diaphragm are circumferentially spaced apart.
The invention has the following beneficial effects:
The present invention provide it is a kind of for collecting the contact lens of tear protein, any power of no implantation the case where Under, it is acted using the blink of wearer itself, squeezes outer layer pumping diaphragm, pressure is generated in the pump chamber of " valveless " scalable pump of internal layer Power flows tear in runner.Topology Structure Design is carried out by the collecting protein room to internal layer and surface chemistry is repaired Decorations, enhance the absorption of specific protein.The contact lens that multizone of the invention collects tear protein is harmless to wearer, Albumen is collected using the blink movement of wearer itself, overcomes the defect that present stimulus method is collected in vitro.And the albumen collected Concentration is high, high specificity.
Detailed description of the invention
Fig. 1 is the contact lens structural schematic diagram of an embodiment of the present invention.
Fig. 2 is the endothecium structure figure in a kind of contact lens of embodiment with Corneal Contact.
Fig. 3 is the layer structure figure that contacts with eyelid in a kind of contact lens of embodiment.
Fig. 4 is " valveless " scalable micro-pump structure enlarged drawing in a kind of contact lens of embodiment.
Fig. 5 is the collecting protein cell structure enlarged drawing in a kind of contact lens of embodiment.
Appended drawing reference in figure:
10- internal layer, 20- " valveless " scalable Micropump, 21- pump intake, 22- pump chamber, 23- pump discharge, 24- pumping diaphragm, 30- One collecting protein room, 31- collect chamber inlet, 32- collecting chamber, the outlet of 33- collecting chamber, the bottom surface 34- topological structure, the second egg of 40- White collecting chamber, 50- runner, 60- outer layer.
Specific embodiment
It elaborates below to embodiments of the present invention.It is emphasized that following the description is only exemplary , the range and its application being not intended to be limiting of the invention.
Refering to fig. 1 to Fig. 5, in one embodiment, the contact lens include with the internal layer 10 of Corneal Contact and with The outer layer 60 of eyelid contact, can be bonded together to form by double-layer films.Above-mentioned internal layer has runner, multiple pumps for collecting tear Chamber 22, the first protein collecting chamber 30 and the second collecting protein room 40.Above-mentioned superficies can have the pumping diaphragm 24 of multiple protrusions.
Pump intake 21, pump chamber 22, pump discharge 23 and corresponding pumping diaphragm 24 form scalable Micropump 20.Pump chamber inner volume Variation generates internal and external pressure difference, flows into tear from pump intake, pump discharge outflow, subsequently into other regions of runner.
Above-mentioned scalable Micropump 20 obtains power using the movement of wearer's blink, generates pressure difference in pump chamber 22, makes tear Liquid flows in above-mentioned runner 50, and passes through above-mentioned the first protein collecting chamber 30, the second collecting protein room 40, to realize tear The white multizone of liquid eggs is collected.
Preferably, above-mentioned internal layer central symmetry is distributed two for the micro-structure that tear protein is collected, symmetrical configuration distribution Contact lens discontinuity during blink can be reduced, sliding is weakened.
Preferably, above-mentioned the first protein collecting chamber 30 includes collecting chamber inlet 31, collecting chamber 32, collecting chamber outlet 33, receiving Collect the topological structure 34 of room bottom surface.Tear flows into collecting chamber by collecting chamber inlet, and the topological structure of collecting chamber bottom surface increases The specific surface area of bottom surface, the more conducively physical absorption of albumen.
It is further preferred that surface chemical modification is carried out in the chamber of above-mentioned the first protein collecting chamber 30, grafting first The targeted molecular of albumen is specifically modified chamber surfaces, realizes the absorption of specific protein.
Preferably, above-mentioned second collecting protein room 40 includes collecting chamber inlet, collecting chamber, collecting chamber outlet, collecting chamber bottom The topological structure in face.Tear flows into collecting chamber by collecting chamber inlet, and the topological structure of collecting chamber bottom surface increases the ratio of bottom surface Surface area, the more conducively physical absorption of albumen.
It is further preferred that carrying out surface chemical modification in the chamber of above-mentioned second collecting protein room, it is grafted the second egg White targeted molecular is specifically modified chamber surfaces, realizes the absorption of specific protein.
Preferably, above-mentioned outer layer 60 is contacted with eyelid, and there are 10 raised pumping diaphragms 24 on surface.When wearer blinks, eye Eyelid squeezes pumping diaphragm, and pumping diaphragm is compressed, and changes said pump cavity volume, provides power.
Preferably, above-mentioned the first protein collecting chamber, the second collecting protein room, can when being grafted different targeted moleculars To collect the interested albumen of other in tear, there is versatility.
As shown in Figure 1, a kind of multizone collect the contact lens of tear protein by with Corneal Contact internal layer 10 and with 60 two parts of outer layer of eyelid contact.Internal layer 10 is attached on eyeball, and tear is flowed by pump intake 21, then passes through pump chamber 22, it is flowed out from pump discharge 23.Tear enters the first protein collecting chamber 30, the second collecting protein room 40 by runner 50.In tear The first protein, the second albumen is respectively in the first protein collecting chamber 30, and the absorption of the second collecting protein room 40, remaining tear is most It is discharged afterwards in pump discharge 23, realizes that tear follows in contact lens.
The micro-structure of internal layer 10 is shown in detail in Fig. 2, and micro-structure is circumferentially symmetrical.It include " nothing in micro-structure The scalable Micropump 20 of valve ", runner 50 and the first protein collecting chamber 30, the second collecting protein room 40.These micro-structures pass through string Connection connection forms the runner of an opening, tear flow circuit wherein.
Fig. 3 indicates the structure of outer layer 60, and 10 raised pumping diaphragms 24 and pump intake 21, pump are distributed on the surface of outer layer 60 Chamber 22, pump discharge 23 form " valveless " scalable Micropump 20 together.
As shown in figure 4, the course of work of " valveless " scalable Micropump 20 is: when wearer's blink, squeezing pumping diaphragm 24, pump Film 24 is depressed, and the spatial volume of pump chamber 22 is reduced, and generates pressure, and tear is mainly shown as from pump discharge 23 and is discharged.Work as wearing When person opens eyes, pumping diaphragm restores original shape since elasticity pops up.At this point, tear is mainly shown as from pump intake 21 flow into.During wearer blinks with opening eyes, the flowing of tear is realized.
Fig. 5 can clearly show that the structure of the first protein collecting chamber 30 and the second collecting protein room 40, collecting protein room packet It includes and collects chamber inlet 31, collecting chamber 32, collecting chamber outlet 33 and bottom surface topological structure 34.Tear is flowed by collection chamber inlet 31 Enter collecting chamber 32, under the physical absorption of bottom surface topological structure 34, albumen carries out first time adsorption precipitation, the tear not adsorbed Liquid is by 33 outflow of collecting chamber outlet, into runner 50.
It is grafted targeted molecular again on the surface of collecting chamber 32, it is modified to carry out surface.Due to the specificity of targeted molecular, Specific adsorption can be carried out to interested tear protein.Tear protein can carry out second of spy under the action of targeted molecular Anisotropic adsorption precipitation.
Tear protein has carried out the specific adsorption of physical absorption and targeted molecular in collecting chamber 32, adsorbs twice The collecting amount that tear protein can be increased improves the Detection accuracy in later period.
The above content is combine it is specific/further detailed description of the invention for preferred embodiment, cannot recognize Fixed specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, Without departing from the inventive concept of the premise, some replacements or modifications can also be made to the embodiment that these have been described, And these substitutions or variant all shall be regarded as belonging to protection scope of the present invention.

Claims (12)

1. a kind of for collecting the contact lens of tear protein, which is characterized in that including with Corneal Contact internal layer and with The outer layer of eyelid contact, be provided on the internal layer runner for collecting tear, the pump chamber with pump intake and pump discharge with And at least one collecting protein room, the pump chamber is connected in series with the collecting protein room by the runner, on the outer layer It is provided with and corresponds in the pumping diaphragm of the protrusion of the pump chamber, the pump chamber and the pumping diaphragm form scalable Micropump, utilize wearing The movement of person's blink obtains power, generates pressure difference in the pump chamber, tear is made to be pumped into the collecting protein room.
2. contact lens as described in claim 1, which is characterized in that the collecting protein room has outlet, passes through runner To outside drain tear.
3. contact lens as claimed in claim 1 or 2, which is characterized in that be provided with the pump of multiple parallel connections on the internal layer Chamber is for collecting tear.
4. contact lens as claimed in claim 2, which is characterized in that the pump chamber for being provided with multiple parallel connections on the internal layer is used In collecting tear, the pump chamber that multiple parallel connections are additionally provided on the internal layer is used for outside drain tear.
5. contact lens as claimed in claim 1 or 2, which is characterized in that the pump intake of the pump chamber at tear collection Extend to the edge of the contact lens.
6. contact lens as claimed in claim 2, which is characterized in that the pump intake of the pump chamber at tear collection extends To the edge of the contact lens, the pump discharge of the pump chamber at tear discharge extends to the side of the contact lens Edge.
7. contact lens as claimed in claim 1 or 2, which is characterized in that the internal layer and the outer layer shape are identical simultaneously It being matched with cornea shape, the internal layer has multiple micro-structures including the runner, the pump chamber and the collecting protein room, The micro-structure is centrosymmetric distribution on the inner layer.
8. contact lens as claimed in claim 7, which is characterized in that there are two the distributions that is centrosymmetric for the internal layer tool The micro-structure, each micro-structure have being respectively used to collect different albumen and being connected in series by runner two with Upper albumen collecting chamber.
9. contact lens as claimed in claim 8, which is characterized in that the internal layer is between concatenated collecting protein room Pump chamber is provided on runner, the outer layer corresponds to the pump chamber and is provided with pumping diaphragm.
10. such as the described in any item contact lens of claim 1 to 2, which is characterized in that the bottom surface of the collecting protein room has The specific surface area for thering is the profile of fluctuating to increase.
11. such as the described in any item contact lens of claim 1 to 2, which is characterized in that pass through table in the collecting protein room Face chemical modification is grafted the targeted molecular of albumen to be collected.
12. such as the described in any item contact lens of claim 1 to 2, which is characterized in that the pump chamber and the pumping diaphragm are around circle Weekly interval distribution.
CN201810456469.4A 2018-05-14 2018-05-14 It is a kind of for collecting the contact lens of tear protein Active CN108628001B (en)

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CN108628001B true CN108628001B (en) 2019-08-06

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US11550166B2 (en) 2019-06-05 2023-01-10 Coopervision International Limited Contact lenses with microchannels

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198364A (en) * 2005-04-14 2008-06-11 阿库福库斯公司 Corneal optic formed of degradation resistant polymer
CN104035209A (en) * 2014-06-13 2014-09-10 万马电子医疗有限公司 Comfortable corneal contact lens for treating myopia
CN107440831A (en) * 2016-04-14 2017-12-08 庄臣及庄臣视力保护公司 Method and apparatus for increasing advanced Ophthalmoligic instrument oxygen concentration

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198364A (en) * 2005-04-14 2008-06-11 阿库福库斯公司 Corneal optic formed of degradation resistant polymer
CN104035209A (en) * 2014-06-13 2014-09-10 万马电子医疗有限公司 Comfortable corneal contact lens for treating myopia
CN107440831A (en) * 2016-04-14 2017-12-08 庄臣及庄臣视力保护公司 Method and apparatus for increasing advanced Ophthalmoligic instrument oxygen concentration

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