CN108620141A - A kind of animal hypobaric chamber group and application method - Google Patents
A kind of animal hypobaric chamber group and application method Download PDFInfo
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- CN108620141A CN108620141A CN201810274423.0A CN201810274423A CN108620141A CN 108620141 A CN108620141 A CN 108620141A CN 201810274423 A CN201810274423 A CN 201810274423A CN 108620141 A CN108620141 A CN 108620141A
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- hypobaric chamber
- hypobaric
- animal
- pressure
- cabin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
- B01L1/02—Air-pressure chambers; Air-locks therefor
- B01L1/025—Environmental chambers
Abstract
The invention discloses a kind of animal hypobaric chamber group and application methods, the hypobaric chamber group of the present invention has multiple hypobaric chambers, each hypobaric chamber is mutual indepedent, ensure in the same period, the environmental experiment of multiple and different pressure values can be carried out simultaneously, it can individually be handled after the completion of a certain altitude chamber test simultaneously, not influence the continuation of other altitude chamber tests.Both experimental cost and experimental period are alleviated, in turn ensures the comparativity and reliability of same batch experiment effect；The present apparatus, which can be realized, prevents the essence of anti anoxia to connect the research that oxygen cylinder is supplied oxygen by air inlet with counter measure-oxygen supply, the present apparatus.Under the anoxia condition of a certain height, according to aviation oxygen principle, the oxygen concentration of gas can be sucked by adjusting, realizes the oxygen supply of different level (different physiologically equivalent altitudes).
Description
Technical field
The invention belongs to animal scientific experiment apparatus fields, and in particular to a kind of animal hypobaric chamber group and application method.
Background technology
Hypobaric chamber is in Plain research plateau low pressure Environmental insults influence, aviation anoxic and aviation decompression disease etc.
Important experimental assembly.However the animal hypobaric chamber used both at home and abroad at present has the following disadvantages：
One, Laboratory Module only has 1 and is mostly connected directly with vacuum pump, can only carry out a kind of reality of hypobaric every time
It tests, the experiment of different air pressure environment can not be carried out simultaneously, not only increase experimental cost and experimental period, but also be difficult to ensure experiment condition
Control；
Two, the essence preventive means of confrontation high altitude anoxia is oxygen supply, however current animal hypobaric chamber can not mostly be carried out
Oxygen supply research under environment under low pressure；
Three, the upper limit of the speed and decompression that depressurize cannot be satisfied research aviation decompression disease and aviation fulminating altitude anoxia
The needs of model；
Three, cabin composition of gases within can not be analyzed in an experiment, ground can only be dropped to, gas is taken after opening hatch door
It is inaccurate that sample causes gas componant to measure.
Invention content
The purpose of the present invention is to overcome the above shortcomings and to provide a kind of animal hypobaric chamber group and application method, cabin group can
Carry out the experiment of different air pressure environment simultaneously, each hypobaric chamber is mutual indepedent, is independent of each other, and can meet research plateau hypobaric hypoxia ring
Needs of the border to body effect, aviation anoxic and aviation decompression disease.
In order to achieve the above object, a kind of animal hypobaric chamber group, including several hypobaric chambers, hypobaric chamber one end connect air inlet
Mouthful, other end connection buffering cabin, buffering cabin connects vacuum pump, and all hypobaric chambers are all connected with gas composition monitoring system, buffer cabin
Be both provided with pressure sensor in all hypobaric chambers, buffer cabin and all hypobaric chambers be all connected with corresponding height control system.
Height control system includes being separately positioned on the switch of buffering cabin front-end and back-end and being separately positioned on hypobaric chamber
It is single that the switch of switch buffering cabin front-end and back-end and the switch of hypobaric chamber front-end and back-end of front-end and back-end are all connected with control
Member, control unit are used to control the opening and closing of switch.
Corresponding flowmeter is provided at the air inlet of hypobaric chamber.
Gas sample mouth is offered on hypobaric chamber, sample tap passes through piping connection gas composition monitoring system.
Cabin connection buffering cabin pressure gauge is buffered, hypobaric chamber connects hypobaric chamber pressure gauge.
A kind of application method of animal hypobaric chamber group, includes the following steps：
Step 1, according to atmospheric pressure value needed for experiment, difference default control buffers the pressure change section in cabin and hypobaric chamber；
Buffering cabin is connected vacuum pump by step 2, by one end access buffering cabin of hypobaric chamber, the other end access of hypobaric chamber
Air inlet；
Step 3 opens vacuum pump and buffers the height control system in cabin, and air pressure in buffering cabin is adjusted to specified air pressure；
Step 4 moves into experimental animal in hypobaric chamber, closes hatchcover, prevents gas leakage；
Step 5 opens the pressure sensor of hypobaric chamber, opens the height control system of hypobaric chamber, needs to adjust according to experiment
It is whole into outgassing rate, control nacelle decompression rate；
Step 6, after pressure all reaches predetermined pressure in all hypobaric chambers, according to animal individual number, animal tide in hypobaric chamber
Tolerance and hypobaric chamber stereometer calculate feed rate, and adjust the speed of exhaust；
Step 7 when increasing pressure in hypobaric chamber, closes the height control system of corresponding hypobaric chamber, opens air inlet, adjust
Whole air inflow persistently increases the pressure in hypobaric chamber；
Step 8 takes out animal after the pressure in hypobaric chamber rises to normal pressure, completes experiment.
In step 4, the soda lime and discoloration silica gel for absorbing carbon dioxide and vapor are placed in hypobaric chamber.
In step 4, the food and water needed for experiment are placed in hypobaric chamber.
Compared with prior art, hypobaric chamber group of the invention has multiple hypobaric chambers, and each hypobaric chamber is mutual indepedent, ensures
In the same period, the environmental experiment of multiple and different pressure values can be carried out simultaneously, while can after the completion of a certain altitude chamber test
It is individually handled, is not influenced the continuation of other altitude chamber tests.Both experimental cost and experimental period are alleviated, is in turn ensured same
The comparativity and reliability of one batch experiment effect；The present apparatus, which can be realized, prevents and counter measure-essence of anti anoxia
Oxygen supply, the present apparatus connect the research that oxygen cylinder is supplied oxygen by air inlet.Under the anoxia condition of a certain height, according to aviation
Principle is supplied oxygen, the oxygen concentration of gas can be sucked by adjusting, realizes the oxygen supply of different level (different physiologically equivalent altitudes).
Further, the hypobaric chamber of the present apparatus is provided with gas sample mouth, can change to cabin composition of gases within and carry out
Monitoring.Especially when replacing the gas componant in cabin, cabin composition of gases within can be changed and carry out dynamic monitoring.
Further, the present apparatus is provided with pressure gauge, can be monitored in real time to pressure in hypobaric chamber (height) variation, both
The rate that nacelle rises or falls can be effectively monitored, while during the experiment, if pressure sensor breaks down, can led to
The differentiation of pressure vacuum gauge registration is crossed, ensures that experiment effectively carries out.
The method of the present invention experimental can need, by program to the pressure change area of hypobaric chamber and buffering cabin
Between set, the pressure change section of hypobaric chamber is set as object height ± 5% more, and the pressure of the pressure sensor of surge tank becomes
Change section setting, to be considered according to experiment needs, hypobaric chamber object height etc., its object is to can meet hypobaric chamber group
The needs of object height, and the open frequency of vacuum pump can be reduced.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Wherein, 1, vacuum pump；2, cabin is buffered；3, hypobaric chamber；4, pressure gauge；5, gas composition monitoring system；6, height is controlled
System processed；7, flowmeter；8, air inlet；9, bleeding point.
Specific implementation mode
The present invention will be further described below in conjunction with the accompanying drawings.
Referring to Fig. 1, a kind of animal hypobaric chamber group, including several hypobaric chambers 3,3 one end of hypobaric chamber connects air inlet 8, another
End connection buffering cabin 2, buffering cabin 2 connect vacuum pump 1, offer gas sample mouth on hypobaric chamber 3, sample tap passes through piping connection
Gas composition monitoring system 5 buffers and is both provided with pressure sensor in cabin 2 and all hypobaric chambers 3, buffers cabin 2 and all low pressure
Cabin 3 is all connected with corresponding height control system, and corresponding flowmeter 7 is provided with before hypobaric chamber 3, buffers cabin 2 and all hypobaric chambers 3
It is all connected with corresponding pressure gauge 4
Height control system 6 includes being separately positioned on the switch of buffering 2 front-end and back-end of cabin and being separately positioned on low pressure
The switch of 3 front-end and back-end of switch and hypobaric chamber of switch buffering 2 front-end and back-end of cabin of 3 front-end and back-end of cabin is all connected with control
Unit processed, control unit are used to control the opening and closing of switch.
The application method of the present invention, includes the following steps：
1) according to atmospheric pressure value needed for experiment (height above sea level), the pressure sensing of difference default control surge tank 2 and hypobaric chamber 3
The pressure change section of device.
2) each device of connecting cabin group and pipeline, and check air-tightness.
3) it opens vacuum pump 1 and buffers the control system power supply in cabin 2, buffering cabin 2 is risen into specified altitude assignment.
4) experimental animal is moved into hypobaric chamber 3, appropriate soda lime and discoloration silica gel is put into hypobaric chamber 3, to absorb two
Carbonoxide and vapor, long time-course experiments need to give foot food, water (to supply water and use ball-valve type water fountain, bottom of thermos opens diameter about
The circular hole of 2mm makes gas pressure in water bottle be consistent always with cabin internal pressure power), hatchcover is closed, gas leakage is prevented.
5) rise hypobaric chamber 3, open 3 pressure sensor of hypobaric chamber and power of electromagnetic valve, negative-pressure cup switch is opened, according to reality
It tests needs to adjust into outgassing rate, and according to 4 registration of pressure gauge, controls the rate of climb.Such as in research decompression sickness or fulminant
When high altitude anoxia, it is desirable that hypobaric chamber 3 rises to 20000m or more in 1min, is essentially off air inlet at this time, and opens big pumping
Mouthful.
6) it when rising to 3 setting height of hypobaric chamber, is added according to animal individual number, animal tidal volume, 3 stereometer of hypobaric chamber
Gas velocity rate, and the speed of exhaust is adjusted, when the height of hypobaric chamber 3 being made to change in ± 5% range of object height, height change speed
The meter per second of rate≤100.Simultaneously because each hypobaric chamber 3 is mutual indepedent in the group of cabin, the setting height of each hypobaric chamber 3 can differ.And
When carrying out oxygen supply experiment, each hypobaric chamber 3 can also be connected from the steel gas cylinder of different oxygen concentrations, can be carried out at the same time varying environment ginseng
Several experiments.
7) it when declining hypobaric chamber 3 (when acute experiment completion or long-term experiment, midway supplements drinking water, replaces bedding and padding), closes
All power supplys adjust inlet air flow scale, adjust air inflow, make fall off rate≤10m/s, prevent ear legion.When in the group of cabin
When only needing to decline a certain hypobaric chamber 3, the lock pressure force snesor power supply only need to be closed, the solenoid valve being connected at this time with the cabin closes
Close, the cabin can only air inlet, can not be evacuated.
8) animal is taken out after being down to ground, and clean and maintenance is carried out to hypobaric chamber 3.
Such as when altitude simulating 5000m pulmonary hypertension model in rats, the pressure of 3 pressure sensor of each hypobaric chamber setting becomes
It is about 390-420mmHg (about 4750-5250m) to change section, i.e., as pressure >=420mmHg in hypobaric chamber 3, solenoid valve is opened,
Bleeding point 9 is evacuated；As pressure≤390mmHg in hypobaric chamber 3, solenoid valve is closed, and pumping stops.Height above sea level in hypobaric chamber 3
Degree is maintained always between 4750-5250m.The pressure change section of the pressure sensor setting in buffering cabin 2 may be set to 40-
200mmHg (about 10000-20000m), i.e. pressure >=200mmHg when buffering cabin 2, vacuum pump 1 start to be evacuated, when buffering cabin 2
Pressure≤40mmHg, pumping stop, and vacuum pump is closed.
The air inlet of hypobaric chamber 3 can be adjusted artificially manually with the speed of exhaust, and the rate of 3 rise and fall of hypobaric chamber is made to have
Adjustability, the presence in simultaneous buffering cabin 2 more increases the adjustable range of 3 speed of exhaust of hypobaric chamber, and then can meet inhomogeneity
The needs of type experiment ensure that cabin group it is sudden and violent can also to can be used as aviation as the research tool of acute and chronic high altitude anoxia disease
The research means of hair property anoxic and aviation decompression disease.
The essence of anti anoxia is prevented with counter measure to be oxygen supply, the present apparatus can connect oxygen cylinder by air inlet 8
The research supplied oxygen.Under the anoxia condition of a certain height, according to aviation oxygen principle, the oxygen that gas can be sucked by adjusting is dense
Degree realizes the oxygen supply of different level (different physiologically equivalent altitudes).For example, at height above sea level 5000m (405mmHg), when sucking gas
When oxygen concentration is about 42%, physiologically equivalent altitude is sea level 0m (760mmHg), when sucking the oxygen concentration of gas and being about 33%,
Its physiologically equivalent altitude is 1500m (634mmHg).
Claims (8)
1. a kind of animal hypobaric chamber group, which is characterized in that including several hypobaric chambers (3), hypobaric chamber (3) one end connects air inlet
(8), other end connection buffering cabin (2), buffering cabin (2) connection vacuum pump (1), all hypobaric chambers (3) are all connected with gas componant prison
Examining system (5), buffers cabin (2) and all hypobaric chambers (3) are both provided with pressure sensor, buffers cabin (2) and all hypobaric chambers (3)
It is all connected with corresponding height control system (6).
2. a kind of animal hypobaric chamber group according to claim 1, which is characterized in that height control system (6) includes difference
It is arranged and is buffering the switch of cabin (2) front-end and back-end and be separately positioned on the switch buffering cabin of hypobaric chamber (3) front-end and back-end
(2) switch of switch and hypobaric chamber (3) front-end and back-end of front-end and back-end is all connected with control unit, and control unit is for controlling
Make the opening and closing of switch.
3. a kind of animal hypobaric chamber group according to claim 1, which is characterized in that set at the air inlet (8) of hypobaric chamber (3)
It is equipped with corresponding flowmeter (7).
4. a kind of animal hypobaric chamber group according to claim 1, which is characterized in that offer gas on hypobaric chamber (3) and take
Sample mouth, sample tap pass through piping connection gas composition monitoring system (5).
5. a kind of animal hypobaric chamber group according to claim 1, which is characterized in that buffering cabin (2) connection buffering lock pressure power
Table, hypobaric chamber (3) connect hypobaric chamber pressure gauge (4).
6. the application method of animal hypobaric chamber group described in claim 1 a kind of, which is characterized in that include the following steps：
Step 1, according to atmospheric pressure value needed for experiment, difference default control buffers the pressure change area in cabin (2) and hypobaric chamber (3)
Between；
Step 2, by buffering cabin (2) connection vacuum pump (1), by one end access buffering cabin (2) of hypobaric chamber (3), hypobaric chamber (3)
The other end access air inlet (8)；
Step 3 opens vacuum pump (1) and buffers the height control system (6) of cabin (2), buffering cabin (2) interior air pressure is adjusted to
Specified air pressure；
Step 4 moves into experimental animal in hypobaric chamber (3), closes hatchcover, prevents gas leakage；
Step 5 opens the pressure sensor of hypobaric chamber (3), the height control system (6) of hypobaric chamber (3) is opened, according to experiment
It needs to adjust into outgassing rate, controls hypobaric chamber decompression rate；
Step 6, after the interior pressure of all hypobaric chambers (3) all reaches predetermined pressure, according to the interior animal individual number of hypobaric chamber (3), animal
Tidal volume and hypobaric chamber (3) stereometer calculate feed rate, and adjust the speed of exhaust；
Step 7 when increasing hypobaric chamber (3) interior pressure, closes the height control system (6) of corresponding hypobaric chamber (3), opens air inlet
Mouth (8) adjusts air inflow, persistently increases the pressure in hypobaric chamber (3)；
Step 8 takes out animal after the pressure in hypobaric chamber (3) rises to normal pressure, completes experiment.
7. the application method of animal hypobaric chamber group according to claim 6 a kind of, which is characterized in that in step 4, low
The soda lime and discoloration silica gel for absorbing carbon dioxide and vapor are placed in ballasting (3).
8. the application method of animal hypobaric chamber group according to claim 6 a kind of, which is characterized in that in step 4, low
The food and water needed for experiment are placed in ballasting (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810274423.0A CN108620141A (en) | 2018-03-29 | 2018-03-29 | A kind of animal hypobaric chamber group and application method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810274423.0A CN108620141A (en) | 2018-03-29 | 2018-03-29 | A kind of animal hypobaric chamber group and application method |
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| CN108620141A true CN108620141A (en) | 2018-10-09 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202146787U (en) * | 2011-05-30 | 2012-02-22 | 天津开发区合普工贸有限公司 | Intelligent ecological gas environment simulation experiment device |
| CN104959171A (en) * | 2015-05-28 | 2015-10-07 | 西安富康空气净化设备工程有限公司 | Experimental animal low-pressure cabin for plateau medicine research, and pressure control method based on experimental animal low-pressure cabin |
| CN106137643A (en) * | 2016-08-11 | 2016-11-23 | 北京众实迪创科技发展有限责任公司 | Zoopery high-low pressure oxygen storehouse |
| WO2017014410A1 (en) * | 2015-07-22 | 2017-01-26 | 한국항공우주연구원 | Low-pressure chamber providing preset air pressure |
| CN206505323U (en) * | 2016-12-30 | 2017-09-19 | 中国人民解放军第四军医大学 | A kind of animal hypobaric chamber pressure controller device |
-
2018
- 2018-03-29 CN CN201810274423.0A patent/CN108620141A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202146787U (en) * | 2011-05-30 | 2012-02-22 | 天津开发区合普工贸有限公司 | Intelligent ecological gas environment simulation experiment device |
| CN104959171A (en) * | 2015-05-28 | 2015-10-07 | 西安富康空气净化设备工程有限公司 | Experimental animal low-pressure cabin for plateau medicine research, and pressure control method based on experimental animal low-pressure cabin |
| WO2017014410A1 (en) * | 2015-07-22 | 2017-01-26 | 한국항공우주연구원 | Low-pressure chamber providing preset air pressure |
| CN106137643A (en) * | 2016-08-11 | 2016-11-23 | 北京众实迪创科技发展有限责任公司 | Zoopery high-low pressure oxygen storehouse |
| CN206505323U (en) * | 2016-12-30 | 2017-09-19 | 中国人民解放军第四军医大学 | A kind of animal hypobaric chamber pressure controller device |
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Application publication date: 20181009 |
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