CN108619031A - A kind of dermatitis frost and preparation method thereof containing plant extracts - Google Patents
A kind of dermatitis frost and preparation method thereof containing plant extracts Download PDFInfo
- Publication number
- CN108619031A CN108619031A CN201810707533.1A CN201810707533A CN108619031A CN 108619031 A CN108619031 A CN 108619031A CN 201810707533 A CN201810707533 A CN 201810707533A CN 108619031 A CN108619031 A CN 108619031A
- Authority
- CN
- China
- Prior art keywords
- parts
- water
- weight
- bath
- grades
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a kind of dermatitis frost and preparation method thereof containing plant extracts, the dermatitis frost include following component by weight：60 77 parts of the fruit of ear base water amaranth, 115 135 parts of the blade of beach wood Morinda offcinalis How, 155 175 parts of the petal of villus shrub lespedeza, 10 parts of emulsifier, 380 parts of water.Dermatitis frost is made by a series of preparation processes.The dermatitis frost of the present invention is directed to photosensitive dermatitis obvious effect, and quick and natural safety is without side-effects.
Description
Technical field
The present invention relates to a kind of dermatitis frost and preparation method thereof containing plant extracts, belongs to cosmetic technical field.
Background technology
Photosensitive dermatitis is to be detected in a few peoples caused by patient is to ultraviolet light allergy, patient 1 usually after solarization~
It falls ill after 2 days, fash is mainly in face, neck and throat " V " shape area, the back of the hand and upper limb and stretches side, shows as small papule, little Shui
Bubble feels itch, such as not active treatment, can form chronic light sensitive dermatoses.Its generation will there are two conditions, first, exogenous
Photosensitive agent through skin contact or it is for oral administration absorb, second is that skin absorbs the light of certain energy and certain wavelength, caused by skin
Damage form it is varied, can behave as edematous erythema, papule, patch, tubercle, skin lesion distribution be confined to light exposed portion
Part, such as before head (hair sparse person), double foreheads, ear, nape, the more clear position in the back of the hand boundary, epidermis shape erythema is even
Or maculopapule, light red, scarlet or kermesinus are different, less serious case is the small pieces being dispersed in, and severe one can be fused into sheet, companion or not companion's water
It is swollen, can have with furfur and pigmentation, all patients with the state of an illness and itch in various degree or burning heat sensation.
Photo-allergy is dermopathic caused by photo patch test is suitable for the clinically institute photoallergen with suspicion in the presence of contact
Detection, including：1. previously having photosensitive diseases history, such as chronic actinic dermatitis, polymorphous light eruption, actinic pruigo, daylight
The unknown photosensitive diseases etc. of property nettle rash, reason；2. there is the skin lesion of eczema sample and solarization postemphasis in summer exposure position；③
The dermatitis that any season occurs at exposure position；4. dermatitis caused by the past external application suncream, non-steroidal anti-inflammatory drugs (NASID)；
5. Occupational contact photodermatitis.Its basic principle is after photoallergen is pasted on skin for a period of time, then through certain wavelength
Light irradiation, photoallergen luminous energy effect under, make before haptens become haptens, is combined with skin protein to be formed entirely resist
Original, the latter stimulate body to generate antibody or cell immune response.Individual after sensitization is contacted again identical sensitizing factor or has
When the substance of cross allergy, body generates a series of allergy, the reactions such as macroscopic erythema, papule, blister occurs, from
And judge photoreactivity of the skin to photoallergen.It is mainly used for the etiological diagnosis of photoallergic contact dermatitis, determination causes
The photoallergen of the reaction.
The treatment photosensitive dermatitis such as PIKANG SHUANG, power Kang Shuan, treatment eczema emulsifiable paste are commonly used in the prior art, but effect is not
Enough ideals, and have different degrees of side effect, therefore the present invention is intended to seek a kind of dermatitis frost containing plant tissue materials and can control
Photosensitive dermatitis is treated, quick and natural safety is without side-effects.
Invention content
The object of the present invention is to provide a kind of the dermatitis frost and preparation method thereof containing plant extracts, the dermatitis frost effect
Obviously, quick, natural safety.
The present invention to achieve the goals above, using following technical scheme：
A kind of dermatitis frost containing plant extracts, it is characterised in that include following components by weight：
60-77 parts of the fruit of ear base water amaranth, preferred weight part ranging from 65-72；
115-135 parts of the blade of beach wood Morinda offcinalis How, preferred weight part ranging from 120-127；
155-175 parts of the petal of villus shrub lespedeza, preferred weight part ranging from 162-170；
10 parts of emulsifier；
380 parts of water
In the present invention, function additive, ear base water amaranth (Classification system are wanted based on three kinds of plants：Ammannia arenaria
H.B.K. it is) Lythraceae Ammannia draft, uprightly, 15-60 centimetres high, capsule oblate spheroid, about 1/3 protrudes from calyx when ripe
Except, aubergine, 2-3.5 millimeters of diameter, at irregular circumscissile, it is wet that the fruit of the ear base water amaranth used in the present invention picks up from Henan
In ground and rice terrace；Beach wood Morinda offcinalis How (Classification system：Morinda citrifolia L.) be Rubiaceae Morinda shrub extremely
Dungarunga, leaf are interacted to life, and oblong, ellipse or oval are 12-25 centimetres long, and both ends are tapering or anxious sharp, usually have light
Pool, hairless, full edge, it is flat that the blade of beach wood Morinda offcinalis How used in the present invention picks up from Hainan Island beach；Villus shrub lespedeza (Latin
Scientific name：Lespedeza tomentosa (Thunb.) Sieb.ex Maxim.) it is pulse family lespedeza shrub, up to 1 meter, always
The petal of locusta basidixed or the villus shrub lespedeza used in stem top axillary, corolla yellow or yellow-white, the present invention picks up from
Between 1000 meters of shrubberies below of Jiangxi Province's height above sea level.The emulsifier brand used in the present invention is woods good fortune, is purchased from Guangzhou Lin Fusheng
Object science and technology.
The method of dermatitis frost containing plant extracts as described above, it is characterised in that include the following steps：
(1) by the fruit 60-77 parts by weight of ear base water amaranth, the blade 115-135 parts by weight of beach wood Morinda offcinalis How, villus Hu branch
Filter paper suck dry moisture is used after the petal 155-175 parts by weight cleaning of son, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
The water-bath brand used in the preparation process (2) of dermatitis frost of the present invention and (5) is to win fast, model HH.S11-
6, win fast medical bio-instruments limited liability company purchased from Shanghai；The ultrasonic extraction instrument brand used in preparation process (3) is sea
It opens up, model HI-T00, opens up mechanical Science and Technology Ltd. purchased from sea, autoclave brand is STIK, model MJ-54A, purchased from north
Be bestowed by heaven tech commerce and trade Co., Ltd in capital；The shaking table brand used in preparation process (4) is intelligence city, and model ZWYR-240 is purchased from
Shanghai ZHICHENG Anaiytical Instrument Manufacturing Co., Ltd..
Properties of product evaluation test of the present invention is as follows：
One, skin irritation test：
Select 2.5~3kg healthy rabbits 60, every rabbit back is symmetrical to select shaving 2.5cm2 at 20, right with itself
According to test method(s) carry out, every time apply 0.5g products of the present invention, twice daily, left or right side is smeared at random, observe and record for 24 hours,
The reacting phenomenon of skin after 72h.
The result shows that：It applies product of the present invention and has no that the local stimulations such as rubefaction, dermexanthesis, water lump are reacted for 24 hours, after 72h, say
Bright dermatitis frost of the present invention is to be perfectly safe, without any adverse reactions.
Two, efficacy validation
The 210 35-45 Sui volunteer for suffering from 4 grades of photosensitive dermatitis is selected, each 105 people of men and women, test site is Jiangxi Province
Nanchang City, the above volunteer is checked by the hospital dermatology department expert of Nanchang City, Jiangxi Province 12 to be complied with standard and selects, and is divided into 15
Group, 14 groups are test group, and 1 group is control group, and every group of 14 people, wherein each 7 people of men and women, control group volunteer do not do any place
Reason, test group volunteer use product of the present invention, daily morning and evening respectively to smear primary, skin of the smearing position outside being exposed to, continuously
Using three months, test in 1 day July in 2016,30 end of day of September, after the test 1 day to October October in 2016
5 days, photo patch test done to every volunteer respectively on October 1st, 2017 to October 5, radiation source is wavelength 400nm's
Long wave ultraviolet fluorescent lamp, observes and records skin, according to the recommendation of International Contact Dermatitis research group (ICDRG),
With 0-4 grades of expression dermoreaction intensity：0 grade of cutaneous manifestations is normal；1 grade of cutaneous manifestations is to only have slight erythema；2 grades of skins
Moderate erythema is shown as with light intermediate edema or infiltration, may occur in which a small number of papules；3 grades of cutaneous manifestations are notable erythema, infiltration, water
Swollen, more papule may occur in which that minority is dispersed in blister；4 grades of cutaneous manifestations are notable erythema, infiltration, oedema, are merged with more gathering
Property blister, bleb or ulcer.Photo patch test is the prior art, and those skilled in the art should know.Note：During experiment, will
The eating habit of hope person and living habit etc. do not require；If during experiment, volunteer occurs emergency situations and stops immediately
Only test.
Specific implementation mode
Embodiment 1-14 is test group, and embodiment 15 is control group, and 14 people of number, wherein men and women each 7 are tested per embodiment
People, control group volunteer is without any processing, and test group volunteer uses product of the present invention, and each smearing is primary sooner or later daily, smears
Position is being exposed to outer skin, is used continuously three months, tests in 1 day July in 2016,30 end of day of September, experiment knot
Hot spot patch examination is done to every volunteer respectively on October 1st, 2016 to October 5, on October 1st, 2017 to October 5 after beam
It tests, radiation source is the long wave ultraviolet fluorescent lamp of wavelength 400nm, skin is observed and recorded, according to International Contact skin
The recommendation of scorching research group (ICDRG), with 0-4 grades of expression dermoreaction intensity：0 grade of cutaneous manifestations is normal；1 grade of skin table
It is now to only have slight erythema；2 grades of cutaneous manifestations are moderate erythema with light intermediate edema or infiltration, may occur in which a small number of papules；3 grades of skins
Skin shows as notable erythema, infiltration, oedema, and more papule may occur in which that minority is dispersed in blister；4 grades of cutaneous manifestations be notable erythema,
Infiltration, oedema, with more gathering amalgamation blister, bleb or ulcer.Photo patch test is the prior art, those skilled in the art
It should know.Note：During experiment, the eating habit of volunteer and living habit etc. do not require；If during experiment, aspiration
Person occurs emergency situations and stops experiment immediately.
With reference to specific embodiment, the invention will be further described：
Embodiment 1
The present embodiment dermatitis frost through the following steps that complete：
(1) by 68 parts by weight of fruit of ear base water amaranth, 125 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 165 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 2
The present embodiment dermatitis frost through the following steps that complete：
(1) by 65 parts by weight of fruit of ear base water amaranth, 120 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 162 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 3
The present embodiment dermatitis frost through the following steps that complete：
(1) by 70 parts by weight of fruit of ear base water amaranth, 123 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 170 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 4
The present embodiment dermatitis frost through the following steps that complete：
(1) by 72 parts by weight of fruit of ear base water amaranth, 127 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 167 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 5
The present embodiment dermatitis frost through the following steps that complete：
(1) by 60 parts by weight of fruit of ear base water amaranth, 115 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 155 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 6
The present embodiment dermatitis frost through the following steps that complete：
(1) by 62 parts by weight of fruit of ear base water amaranth, 117 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 157 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 7
The present embodiment dermatitis frost through the following steps that complete：
(1) by 75 parts by weight of fruit of ear base water amaranth, 130 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 160 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 8
The present embodiment dermatitis frost through the following steps that complete：
(1) by 77 parts by weight of fruit of ear base water amaranth, 135 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza flower
Filter paper suck dry moisture is used after the cleaning of 175 parts by weight of valve, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 9
The present embodiment dermatitis frost through the following steps that complete：
(1) filter paper suck dry moisture is used after cleaning 68 parts by weight of fruit of ear base water amaranth, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in purees that (1) step obtains, temperature is 65 DEG C, water
Bath heating 5 hours, was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 10
The present embodiment dermatitis frost through the following steps that complete：
(1) filter paper suck dry moisture is used after cleaning 125 parts by weight of blade of beach wood Morinda offcinalis How, is put into mortar and is ground to mud
Shape；
(2) it is placed in water-bath after 120 parts by weight water being added in purees that (1) step obtains, temperature is 65 DEG C, water
Bath heating 5 hours, was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
Embodiment 11
The present embodiment dermatitis frost through the following steps that complete：
(1) filter paper suck dry moisture is used after cleaning 165 parts by weight of petal of villus shrub lespedeza, is put into mortar and is ground to mud
Shape；
(2) it is placed in water-bath after 120 parts by weight water being added in purees that (1) step obtains, temperature is 65 DEG C, water
Bath heating 5 hours, was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
| Subject number | In October, 2016 cutaneous manifestations | In October, 2017 cutaneous manifestations |
| 1 | 3 grades | 2 grades |
| 2 | 2 grades | 2 grades |
| 3 | 2 grades | 2 grades |
| 4 | 2 grades | 2 grades |
| 5 | 3 grades | 2 grades |
| 6 | 2 grades | 3 grades |
| 7 | 3 grades | 3 grades |
| 8 | 3 grades | 3 grades |
| 9 | 3 grades | 3 grades |
| 10 | 3 grades | 2 grades |
| 11 | 3 grades | 3 grades |
| 12 | 2 grades | 3 grades |
| 13 | 2 grades | 3 grades |
| 14 | 3 grades | 3 grades |
Embodiment 12
The present embodiment dermatitis frost through the following steps that complete：
(1) it will be blotted with filter paper after 68 parts by weight of fruit of ear base water amaranth, the cleaning of 125 parts by weight of blade of beach wood Morinda offcinalis How
Moisture is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
| Subject number | In October, 2016 cutaneous manifestations | In October, 2017 cutaneous manifestations |
| 1 | 2 grades | 2 grades |
| 2 | 2 grades | 2 grades |
| 3 | 1 grade | 2 grades |
| 4 | 2 grades | 1 grade |
| 5 | 2 grades | 2 grades |
| 6 | 2 grades | 2 grades |
| 7 | 3 grades | 2 grades |
| 8 | 2 grades | 1 grade |
| 9 | 2 grades | 2 grades |
| 10 | 2 grades | 2 grades |
| 11 | 3 grades | 2 grades |
| 12 | 2 grades | 2 grades |
| 13 | 2 grades | 2 grades |
| 14 | 1 grade | 2 grades |
Embodiment 13
The present embodiment dermatitis frost through the following steps that complete：
(1) it will be blotted with filter paper after 68 parts by weight of fruit of ear base water amaranth, the cleaning of 165 parts by weight of petal of villus shrub lespedeza
Moisture is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
| Subject number | In October, 2016 cutaneous manifestations | In October, 2017 cutaneous manifestations |
| 1 | 2 grades | 2 grades |
| 2 | 2 grades | 2 grades |
| 3 | 1 grade | 2 grades |
| 4 | 2 grades | 2 grades |
| 5 | 2 grades | 1 grade |
| 6 | 2 grades | 2 grades |
| 7 | 2 grades | 2 grades |
| 8 | 1 grade | 2 grades |
| 9 | 2 grades | 2 grades |
| 10 | 2 grades | 2 grades |
| 11 | 1 grade | 1 grade |
| 12 | 2 grades | 2 grades |
| 13 | 3 grades | 2 grades |
| 14 | 2 grades | 2 grades |
Embodiment 14
The present embodiment dermatitis frost through the following steps that complete：
(1) filter paper will be used after 125 parts by weight of blade of beach wood Morinda offcinalis How, the cleaning of 165 parts by weight of petal of villus shrub lespedeza
Suck dry moisture is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature 65
DEG C, heating water bath 5 hours was sufficiently stirred once every 30 minutes, is taken out after 5 hours spare；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, is put into and goes out after taking-up
In bacterium pot, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed
110 turns per minute are set as, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting
It is 85 DEG C, is slowly added into 10 parts by weight Emulsifier, is stirred continuously, taken out after one hour, is cooled to 25 DEG C to get to the dermatitis
Frost.
Test result：
| Subject number | In October, 2016 cutaneous manifestations | In October, 2017 cutaneous manifestations |
| 1 | 3 grades | 2 grades |
| 2 | 2 grades | 2 grades |
| 3 | 2 grades | 1 grade |
| 4 | 2 grades | 2 grades |
| 5 | 2 grades | 2 grades |
| 6 | 1 grade | 2 grades |
| 7 | 2 grades | 1 grade |
| 8 | 2 grades | 2 grades |
| 9 | 2 grades | 2 grades |
| 10 | 2 grades | 2 grades |
| 11 | 1 grade | 2 grades |
| 12 | 2 grades | 1 grade |
| 13 | 2 grades | 2 grades |
| 14 | 2 grades | 2 grades |
Embodiment 15
The present embodiment is control group, and volunteer's skin is without any processing.
Test result：
Claims (2)
1. a kind of dermatitis frost containing plant extracts, it is characterized in that being prepared by the following steps：
(1) by 68 parts by weight of fruit of ear base water amaranth, 125 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza petal 165
Filter paper suck dry moisture is used after parts by weight cleaning, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature is 65 DEG C, water
Bath heating 5 hours, was sufficiently stirred once every 30 minutes, was sufficiently stirred once, is taken out after 5 hours spare every 30 minutes；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, and autoclave is put into after taking-up
In, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after about 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed setting
It it is 110 turns per minute, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting 85
DEG C, 10 parts by weight Emulsifier are slowly added into, are stirred continuously, takes out, is stirred continuously after one hour, takes out, is cooled to after one hour
25 DEG C to get white to the dermatitis.
2. a kind of preparation method of the dermatitis frost containing plant extracts, is made it is characterized in that including the following steps：
(1) by 68 parts by weight of fruit of ear base water amaranth, 125 parts by weight of blade of beach wood Morinda offcinalis How, villus shrub lespedeza petal 165
Filter paper suck dry moisture is used after parts by weight cleaning, is put into mortar and is ground to pureed；
(2) it is placed in water-bath after 120 parts by weight water being added in pureed mixture that (1) step obtains, temperature is 65 DEG C, water
Bath heating 5 hours, was sufficiently stirred once every 30 minutes, was sufficiently stirred once, is taken out after 5 hours spare every 30 minutes；
(3) by the mixture ultrasonic extraction 70 minutes after (2) step water-bath, temperature setting is 10 DEG C, and autoclave is put into after taking-up
In, sterilising temp is set as 120 DEG C, and sterilizing pressure is set as 1.0KPa, is taken out after about 25 minutes spare；
(4) it is sealed after the mixture to sterilize through (3) step being bottled, is placed on shaking table and cultivates 20 days, shaking speed setting
It it is 110 turns per minute, temperature setting is 40 DEG C；
(5) 260 parts by weight water are added in the mixture for obtaining (4) step, are placed on heating water bath in water-bath, temperature setting 85
DEG C, 10 parts by weight Emulsifier are slowly added into, are stirred continuously, takes out, is stirred continuously after one hour, takes out, is cooled to after one hour
25 DEG C to get white to the dermatitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810707533.1A CN108619031A (en) | 2018-07-02 | 2018-07-02 | A kind of dermatitis frost and preparation method thereof containing plant extracts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810707533.1A CN108619031A (en) | 2018-07-02 | 2018-07-02 | A kind of dermatitis frost and preparation method thereof containing plant extracts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108619031A true CN108619031A (en) | 2018-10-09 |
Family
ID=63689238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810707533.1A Withdrawn CN108619031A (en) | 2018-07-02 | 2018-07-02 | A kind of dermatitis frost and preparation method thereof containing plant extracts |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108619031A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924119A (en) * | 2017-04-17 | 2017-07-07 | 佛山汇沐化学科技有限公司 | A kind of sun-proof reparation air cushion BB frosts |
| CN107550782A (en) * | 2017-09-22 | 2018-01-09 | 海门臻凯工业设计有限公司 | A kind of suncream |
| CN107737041A (en) * | 2017-11-17 | 2018-02-27 | 珠海姗拉娜化妆品有限公司 | A kind of novel skin antiallergic maintenance composition, skin repair frost and preparation method thereof |
| CN107929152A (en) * | 2017-12-25 | 2018-04-20 | 广州智媛生物科技有限公司 | Cosmetic composition of sun-proof reparation and preparation method thereof |
-
2018
- 2018-07-02 CN CN201810707533.1A patent/CN108619031A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924119A (en) * | 2017-04-17 | 2017-07-07 | 佛山汇沐化学科技有限公司 | A kind of sun-proof reparation air cushion BB frosts |
| CN107550782A (en) * | 2017-09-22 | 2018-01-09 | 海门臻凯工业设计有限公司 | A kind of suncream |
| CN107737041A (en) * | 2017-11-17 | 2018-02-27 | 珠海姗拉娜化妆品有限公司 | A kind of novel skin antiallergic maintenance composition, skin repair frost and preparation method thereof |
| CN107929152A (en) * | 2017-12-25 | 2018-04-20 | 广州智媛生物科技有限公司 | Cosmetic composition of sun-proof reparation and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 李孔定: "《李孔定研经实践录》", 31 October 2016, 中国中医药出版社 * |
| 李建秀等: "《山东药用植物志》", 31 August 2013, 西安交通大学出版社 * |
| 李顺鹏: "《微生物学实验指导》", 31 January 2015, 中国农业出版社 * |
| 袁昌齐等: "《世界植物药》", 31 January 2013, 东南大学出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wilson | On diseases of the skin | |
| CN102973802B (en) | Drug composite for treating sensitive skin and preparation method thereof | |
| Pasricha et al. | Illustrated textbook of dermatology | |
| CN108619031A (en) | A kind of dermatitis frost and preparation method thereof containing plant extracts | |
| CN108434049A (en) | A kind of dermatitis frost of plant formula and preparation method thereof | |
| CN108619029A (en) | A kind of dermatitis repair cream and preparation method thereof | |
| CN108743475A (en) | It is a kind of that there is the dermatitis frost and preparation method thereof for repairing photosensitive dermatitis function | |
| CN108670989A (en) | It is a kind of to be used to repair dermatitis frost of photosensitive dermatitis and preparation method thereof | |
| CN108619030A (en) | It is a kind of to be used to repair dermatitis frost of dermatitis and preparation method thereof | |
| Gupta et al. | Textbook of dermatology for homoeopaths | |
| CN107616936B (en) | Anti-allergy repair composition and application thereof | |
| Fox | Photographic illustrations of skin diseases | |
| Douglass | Skin Diseases: Their Description, Etiology, Diagnosis, and Treatment According to the Law of the Similars | |
| Fox | Photographic illustrations of skin diseases | |
| CN102362873B (en) | Use of Xiaomeng oculentum in preparation of medicines for treating alopecia areata | |
| Simmons et al. | DERMATITIS VENENATA PRODUCED BY AN IRRITANT PRESENT IN THE STEM SAP OF THE MANGO (MANGIFERA INDICA L.) ¹ | |
| CN105663376A (en) | Medicament for treating dermatophytosis and preparation method thereof | |
| CN107760055A (en) | A kind of method of purification of aloe natural dye | |
| CN104784493A (en) | Traditional Chinese medicine for treating pediatric dermatitis eczema and preparation method thereof | |
| Patil et al. | MANAGEMENT OF PEDIATRIC AGE GROUP VITILIGO THROUGH CLASSICS BASED SELF MADE AYURVEDIC EXTERNAL TOPICAL MEDICATION (DHYAS POWDER) AND BAKUCHI OIL–A CASE STUDY | |
| Dearborn | Diseases of the Skin | |
| Robinson | A manual of dermatology | |
| Wolff | Practical Dermatology: A Condensed Manual of Diseases of the Skin: Designed for the Use of Students and Practitioners of Medicine | |
| Blundell | Herbal and traditional medicine in Gozo | |
| Hillier | Hand-book of skin diseases for students and practitioners |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |
|
| WW01 | Invention patent application withdrawn after publication |