CN108614883A - A kind of the tooth database and its method for building up of canalis radicis dentis rating - Google Patents

A kind of the tooth database and its method for building up of canalis radicis dentis rating Download PDF

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Publication number
CN108614883A
CN108614883A CN201810410166.9A CN201810410166A CN108614883A CN 108614883 A CN108614883 A CN 108614883A CN 201810410166 A CN201810410166 A CN 201810410166A CN 108614883 A CN108614883 A CN 108614883A
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tooth
isolated
root
isolated tooth
rating
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唐子圣
王易维
夏文君
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Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
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Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T17/00Three dimensional [3D] modelling, e.g. data description of 3D objects

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Graphics (AREA)
  • Geometry (AREA)
  • Software Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

The invention discloses a kind of tooth database building methods of canalis radicis dentis rating, the described method comprises the following steps:Collect true Isolated Tooth;Isolated Tooth is screened and is modeled;According in vitro dental cast, the root canal morphology feature of Isolated Tooth is analyzed;Multiple and different labels is formulated for Isolated Tooth;Different grade of difficulty are set, the label is combined, different tag combinations is referred to different grade of difficulty.Invention also discloses a kind of tooth databases of canalis radicis dentis rating, including Isolated Tooth raw data module, in vitro dental cast root canal morphology characteristic module, in vitro dental cast label model and Isolated Tooth grade of difficulty module.Tooth database and its method for building up provided by the invention, the support of actual teeth root canal morphology data is provided for clinic, scientific research, teaching, can quickly be directly applied Clinical Skill Teaching, or applied to the academic research etc. to root pipe.

Description

A kind of the tooth database and its method for building up of canalis radicis dentis rating
Technical field
The present invention relates to the tooth database of root canal treatment field more particularly to a kind of canalis radicis dentis rating and its build Cube method.
Background technology
Tooth root canal therapy (RCT) be treat dental pulp disease, periapical disease main method, and for tooth root canal morphology Understanding it is most important for the root canal effect of Dentist, be conducive to root canal preparation and better root-canal filling effect Fruit.There are 28~32 permanent teeths, the root canal morphology of different tooth position different in adult oral cavity;Same tooth position, the root pipe of Different Individual Form and different from.Tooth root canal morphology is ever-changing, it may be said that it is identical that two root canal morphologies are not present in the world Tooth.
Dentist and student should attempt the root with different shape feature as far as possible in the operation training of root canal Governance is treated.But in fact, in existing training operation, selectable root canal morphology, operation difficulty are more single, only simply The tooth teaching mould of root pipe has notable difference with actual teeth root canal morphology.It is right meanwhile in existing clinical, scientific research data Various root canal morphologies also only have descriptive statement, can not provide accurate root canal morphology data information.
Therefore, those skilled in the art is dedicated to developing a kind of tooth database according to canalis radicis dentis rating, number It can really reflect Isolated Tooth root canal morphology according to each independent tooth data in library, true tooth is provided for clinic, scientific research, teaching The support of pulp canal morphological data, and the actual teeth in database is classified according to canalis radicis dentis difficulty.
Invention content
In view of the drawbacks described above of the prior art, the technical problem to be solved by the present invention is to how establish a true tooth The database of pulp canal form, and the actual teeth in database is classified.
To achieve the above object, the present invention provides a kind of tooth database building method of canalis radicis dentis rating, institutes The method of stating includes the following steps:
Step 1 collects true Isolated Tooth;
Step 2 screens Isolated Tooth three times, select defect of teeth more than enamelo-cemental junction, root form it is complete, The Isolated Tooth of unrooted folding;
Step 3 scans Isolated Tooth using MicroCT, and preserves original DICOM data;
Step 4, by mimics software three-dimensional process DICOM data, and be converted to stl file;
Stl file is carried out Isolated Tooth Model Reconstruction by step 5 on geomagic softwares;
Step 6, according in vitro dental cast, further analyze the root canal morphology feature of Isolated Tooth, the root canal morphology feature Including tooth position, root pipe quantity, curvature, root canal cross-section shape, root face ditch, dens in dente;
Step 7, according to every morphological feature described in step 6, formulate multiple and different labels for Isolated Tooth;
Step 8, the different grade of difficulty of setting, are combined the label in step 7, different tag combinations are returned Class selects the tooth of different difficulty root canal morphologies according to different grade of difficulty to different grade of difficulty.
Further, the step 2 further includes:
Step 2.1, according to the shape of Isolated Tooth carry out first time screening, retain defect of teeth more than enamelo-cemental junction, The complete Isolated Tooth of root form
Step 2.2 carries out X-ray plain film shooting to Isolated Tooth, carries out programmed screening, removal defect of teeth is in glaze cementum Below boundary, root folding Isolated Tooth;
Step 2.3 carries out CBCT scannings to Isolated Tooth, carries out third time screening, selecting defect of teeth is having cementum circle Above, root form is complete, Isolated Tooth of unrooted folding;Wherein, the Isolated Tooth repeated with feature tag in database is deleted.
Further, the formulation of step 7 dens in dente position label is the physiology anatomical features first according to each tooth position tooth It is visually observed, indicates specific tooth position, if characteristic anatomic landmark can not be recognized, tooth position is labeled as " other ".
Further, the curvature standard in the step 7 is:0-5 ° be taproot pipe, 6-25 ° be medium flexion root pipe, 26-75 ° is severe crooked root tube, 75 ° of > is reverse-hook shape root pipe.
Further, the curvature of the Isolated Tooth is surveyed according to Schneider mensurations or Weine mensurations or long axis Amount method measures.
Further, the root canal cross-section shape in the step 7 includes C-shaped root, ellipse, triangle.
Further, the grade of difficulty in the step 8, operator can carry out self-defined according to self-demand.
The present invention also provides a kind of tooth database of canalis radicis dentis rating, including Isolated Tooth raw data module, In vitro dental cast root canal morphology characteristic module, in vitro dental cast label model and Isolated Tooth grade of difficulty module, the Isolated Tooth Raw data module is the basis of the in vitro dental cast root canal morphology characteristic module, the in vitro dental cast root canal morphology feature Module is the basis of the in vitro dental cast label model, and the in vitro dental cast label model is the Isolated Tooth grade of difficulty The basis of module.
Further, the Isolated Tooth raw data module includes the original DICOM data of Isolated Tooth, DICOM data turn The Isolated Tooth threedimensional model of the stl file, reconstruction that change.
Further, the Isolated Tooth threedimensional model can really reflect the root canal morphology of Isolated Tooth.
Tooth database building method provided by the invention can store the number of a large amount of true reflection Isolated Tooth root canal morphologies According to and establishing feature tag for Isolated Tooth data, convenient for retrieval, may be directly applied to Clinical Skill Teaching (such as according to not Student of the same grade extracts the tooth of different difficulty or feature, is printed to resin dental cast, and student is made to carry out more individual character The operation training of change), or applied to the academic research etc. to root pipe.
The technique effect of the design of the present invention, concrete structure and generation is described further below with reference to attached drawing, with It is fully understood from the purpose of the present invention, feature and effect.
Description of the drawings
Fig. 1 is the method flow diagram of the preferred embodiment of the present invention;
Fig. 2 is the database monolithically fabricated figure of the preferred embodiment of the present invention.
Specific implementation mode
A preferred embodiment of the present invention is introduced below with reference to Figure of description, keeps its technology contents more clear and just In understanding.The present invention can be emerged from by many various forms of embodiments, and protection scope of the present invention not only limits The embodiment that Yu Wenzhong is mentioned.
As shown in Figure 1, the method for building up of the tooth database for canalis radicis dentis rating, includes 8 steps altogether.
In the following embodiments, by specific the step of telling about tooth Database:
1, true Isolated Tooth is collected.
Because in real world, tooth root canal morphology is ever-changing, and it is complete that two root canal morphologies are not present in the world Identical tooth.And in the teaching or research and development of reality, selectable root canal morphology, operation difficulty are more single.Therefore at this In method, true Isolated Tooth can be collected, ensures the diversity and authenticity of the tooth root canal morphology in data, for the religion of reality It learns or research and development provides abundant and true tooth root pipe data.
2, the complete Isolated Tooth in root of the tooth part is screened.
After having collected true Isolated Tooth, first time screening can be carried out to the Isolated Tooth of collection.This screening is main It is the shape according to Isolated Tooth, selects the qualified Isolated Tooth of shape.Retain defect of teeth below enamelo-cemental junction, root of the tooth The complete Isolated Tooth of form.
3, X-ray plain film shooting is carried out to Isolated Tooth.
Programmed screening is carried out to the Isolated Tooth filtered out for the first time, first shoots X-ray plain film, then according to X-ray plain film, is seen Whether examine Isolated Tooth has whether apparent jackknifing, External apical root resorption comply with standard.Defect of teeth is removed below enamelo-cemental junction, root The Isolated Tooth of folding.
4, CBCT scannings are carried out to Isolated Tooth.
Third time screening is carried out to the Isolated Tooth that programmed screening goes out, CBCT scannings is first carried out, is then scanned according to CBCT As a result it is observed, selecting defect of teeth, cementum circle or more, root form be complete, Isolated Tooth of unrooted folding having;Wherein, it deletes Except the Isolated Tooth repeated with feature tag in database.
5, Isolated Tooth is scanned using MicroCT, and preserves original DICOM data.
To screening the Isolated Tooth left later three times, it is scanned using using MicroCT, and preserve original DICOM Data.
6, by mimics software three-dimensional process DICOM data, and stl file is converted to.
7, stl file is carried out to Isolated Tooth Model Reconstruction on geomagic softwares.
8, according in vitro dental cast, the root canal morphology feature of Isolated Tooth is further analyzed, the root canal morphology feature includes Tooth position, root pipe quantity, curvature, root canal cross-section shape, root face ditch, dens in dente.
9, according to every root canal morphology feature of the Isolated Tooth, multiple and different labels is formulated for Isolated Tooth;
Every root canal morphology feature includes tooth position, root pipe quantity, curvature, root canal cross-section shape, root face ditch, dens in dente The formulation of tooth position label.It is first to be visually observed according to the physiology anatomical features of each tooth position tooth, if observation for tooth position To there are special anatomical features to make a variation, then it is not necessarily to indicate specific tooth position, otherwise indicates specific tooth position;It is to pass through for root pipe quantity Naked eyes are observed;For curvature, Isolated Tooth root canal morphology curvature is measured according to Schneider mensurations or Weine Method or long axis mensuration measure, and the standard of curvature is:0-5 ° be taproot pipe, 6-25 ° be medium flexion root pipe, 26-75 ° It is reverse-hook shape root pipe for severe crooked root tube, 75 ° of >;For root canal cross-section shape, including C-shaped root, ellipse and triangle; For root face ditch, see whether as a certain special anatomic form;For dens in dente, see whether as a certain special anatomic form. According to every root canal morphology feature, multiple labels are formulated for Isolated Tooth.Operator can be self-defined according to self-demand progress, not only It is limited to 6 kinds of root canal morphology features mentioned above.
10, different grade of difficulty are set, the label of Isolated Tooth is combined, different tag combinations is referred to difference Grade of difficulty, the tooth of different difficulty root canal morphologies is selected according to different grade of difficulty.Operator also can to grade of difficulty into Row is self-defined.
As shown in Fig. 2, the monolithically fabricated figure of the tooth database for canalis radicis dentis rating.
In the following embodiments, the composition of tooth database will specifically be told about:
According to the tooth database of canalis radicis dentis rating, including Isolated Tooth raw data module, in vitro dental cast root pipe Four morphological feature module, in vitro dental cast label model and Isolated Tooth grade of difficulty module parts, the Isolated Tooth original number According to module include the original DICOM data of Isolated Tooth, the stl file that DICOM data conversions come, reconstruction Isolated Tooth three-dimensional mould Type, three parts of Isolated Tooth initial data are progressive relationships, are first scanned with MicroCT and obtain the original DICOM of Isolated Tooth Data, then by mimics software three-dimensional process DICOM data, finally stl file is carried out on geomagic softwares from Body dental cast is rebuild, to generate in vitro dental cast.The threedimensional model of Isolated Tooth can really reflect the root canal morphology of Isolated Tooth. The Isolated Tooth raw data module is the basis of the in vitro dental cast root canal morphology characteristic module, the in vitro dental cast root Tubular state characteristic module is the basis of the in vitro dental cast label model, and the in vitro dental cast label model is described in vitro The basis of tooth grade of difficulty module.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is without wound The property made labour, which according to the present invention can conceive, makes many modifications and variations.Therefore, all technician in the art Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea Scheme, all should be in the protection domain being defined in the patent claims.

Claims (10)

1. a kind of tooth database building method of canalis radicis dentis rating, which is characterized in that the described method comprises the following steps:
Step 1 collects true Isolated Tooth;
Step 2 screens Isolated Tooth three times, select defect of teeth more than enamelo-cemental junction, root form is complete, unrooted The Isolated Tooth of folding;
Step 3 scans Isolated Tooth using MicroCT, and preserves original DICOM data;
Step 4, by mimics software three-dimensional process DICOM data, and be converted to stl file;
Stl file is carried out Isolated Tooth Model Reconstruction by step 5 on geomagic softwares;
Step 6, according in vitro dental cast, further analyze the root canal morphology feature of Isolated Tooth, the root canal morphology feature includes Tooth position, root pipe quantity, curvature, root canal cross-section shape, root face ditch, dens in dente;
Step 7, according to every morphological feature described in step 6, formulate multiple and different labels for Isolated Tooth;
Step 8, the different grade of difficulty of setting, are combined the label in step 7, different tag combinations are referred to Different grade of difficulty selects the tooth of different difficulty root canal morphologies according to different grade of difficulty.
2. the tooth database building method of canalis radicis dentis rating as described in claim 1, which is characterized in that the step 2 further include:
Step 2.1 carries out first time screening according to the shape of Isolated Tooth, retains defect of teeth more than enamelo-cemental junction, root of the tooth The complete Isolated Tooth of form;
Step 2.2, to Isolated Tooth carry out X-ray plain film shooting, carry out programmed screening, removal defect of teeth enamelo-cemental junction with Under, root folding Isolated Tooth;
Step 2.3, to Isolated Tooth carry out CBCT scannings, carry out third time screening, select defect of teeth have cementum circle or more, The Isolated Tooth that root form is complete, unrooted is rolled over;Wherein, the Isolated Tooth repeated with feature tag in database is deleted.
3. the tooth database building method of canalis radicis dentis rating as described in claim 1, which is characterized in that the step The formulation of 7 dens in dente position labels is first to be visually observed according to the physiology anatomical features of each tooth position tooth, indicates specific tooth Tooth position is labeled as " other " by position if characteristic anatomic landmark can not be recognized.
4. the tooth database building method of canalis radicis dentis rating as described in claim 1, which is characterized in that the step Curvature standard in 7 is:0-5 ° be taproot pipe, 6-25 ° be medium flexion root pipe, 26-75 ° be 75 ° of severe crooked root tube, > For reverse-hook shape root pipe.
5. the tooth database building method of canalis radicis dentis rating as claimed in claim 4, which is characterized in that described in vitro The curvature of tooth is measured according to Schneider mensurations or Weine mensurations or long axis mensuration.
6. the tooth database building method of canalis radicis dentis rating as described in claim 1, which is characterized in that the step Root canal cross-section shape in 7 includes C-shaped root, ellipse, triangle.
7. the tooth database building method of canalis radicis dentis rating as described in claim 1, which is characterized in that the step Grade of difficulty in 8, operator can carry out self-defined according to self-demand.
8. a kind of tooth database of canalis radicis dentis rating, which is characterized in that including Isolated Tooth raw data module, Isolated Tooth Model root canal morphology characteristic module, in vitro dental cast label model and Isolated Tooth grade of difficulty module, the Isolated Tooth original number It is the basis of the in vitro dental cast root canal morphology characteristic module according to module, the in vitro dental cast root canal morphology characteristic module is The basis of the in vitro dental cast label model, the in vitro dental cast label model are the Isolated Tooth grade of difficulty modules Basis.
9. the tooth database of canalis radicis dentis rating as claimed in claim 8, which is characterized in that the Isolated Tooth original number According to module include the original DICOM data of Isolated Tooth, the stl file that DICOM data conversions come, reconstruction Isolated Tooth three-dimensional mould Type.
10. the tooth database of canalis radicis dentis rating as claimed in claim 9, which is characterized in that the Isolated Tooth is three-dimensional Model can really reflect the root canal morphology of Isolated Tooth.
CN201810410166.9A 2018-05-02 2018-05-02 A kind of the tooth database and its method for building up of canalis radicis dentis rating Pending CN108614883A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021004346A1 (en) * 2019-07-05 2021-01-14 四川大学 Method and system for constructing natural tooth library
CN113619120A (en) * 2021-08-10 2021-11-09 西安交通大学口腔医院 Manufacturing method of 3D printing real tooth model

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN200979767Y (en) * 2006-12-11 2007-11-21 武汉大学 A standardized model simulates the instrument fracture in the root canal of the tooth
CN101797188A (en) * 2010-02-08 2010-08-11 四川大学 Model device for dynamic detection of root canal flushing effect and detection method thereof
CN103826566A (en) * 2011-09-05 2014-05-28 美特瑞牙科有限公司 Method and system for 3d root canal treatment planning
CN104299500A (en) * 2014-04-02 2015-01-21 华中科技大学同济医学院附属同济医院 Root canal preparation effect detection method and device in stomatology teaching
CN105596091A (en) * 2016-03-14 2016-05-25 四川大学 Navigation device for root canal treatment and making method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN200979767Y (en) * 2006-12-11 2007-11-21 武汉大学 A standardized model simulates the instrument fracture in the root canal of the tooth
CN101797188A (en) * 2010-02-08 2010-08-11 四川大学 Model device for dynamic detection of root canal flushing effect and detection method thereof
CN103826566A (en) * 2011-09-05 2014-05-28 美特瑞牙科有限公司 Method and system for 3d root canal treatment planning
CN104299500A (en) * 2014-04-02 2015-01-21 华中科技大学同济医学院附属同济医院 Root canal preparation effect detection method and device in stomatology teaching
CN105596091A (en) * 2016-03-14 2016-05-25 四川大学 Navigation device for root canal treatment and making method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘娜: "中国人数字恒牙数据库构建", 《中国博士学位论文全文数据库 医药卫生科技辑》 *
杜建东: "《口腔疾病综合诊疗常规上》", 30 June 2017 *
赵志河: "《口腔力学生物学》", 31 December 2017 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021004346A1 (en) * 2019-07-05 2021-01-14 四川大学 Method and system for constructing natural tooth library
CN113619120A (en) * 2021-08-10 2021-11-09 西安交通大学口腔医院 Manufacturing method of 3D printing real tooth model

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Application publication date: 20181002