CN108603998B - 通过确定最优扫描轨迹获取载玻片上的样本的聚焦图像的方法、系统和产品 - Google Patents

通过确定最优扫描轨迹获取载玻片上的样本的聚焦图像的方法、系统和产品 Download PDF

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Publication number
CN108603998B
CN108603998B CN201680081622.9A CN201680081622A CN108603998B CN 108603998 B CN108603998 B CN 108603998B CN 201680081622 A CN201680081622 A CN 201680081622A CN 108603998 B CN108603998 B CN 108603998B
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image
grid
images
slide
points
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Chinese (zh)
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CN108603998A (zh
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J·布里登
J·马丁
A·萨卡尔
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Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N1/00—Scanning, transmission or reproduction of documents or the like, e.g. facsimile transmission; Details thereof
    • H04N1/387—Composing, repositioning or otherwise geometrically modifying originals
    • H04N1/3876—Recombination of partial images to recreate the original image
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/67—Focus control based on electronic image sensor signals

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  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Microscoopes, Condenser (AREA)
  • Color Television Image Signal Generators (AREA)
  • Image Analysis (AREA)
  • Automatic Focus Adjustment (AREA)
CN201680081622.9A 2015-12-16 2016-12-14 通过确定最优扫描轨迹获取载玻片上的样本的聚焦图像的方法、系统和产品 Active CN108603998B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268165P 2015-12-16 2015-12-16
US62/268,165 2015-12-16
PCT/EP2016/080970 WO2017102827A1 (en) 2015-12-16 2016-12-14 Auto-focus methods and systems for digital imaging using mutli-spectral trajectories

Publications (2)

Publication Number Publication Date
CN108603998A CN108603998A (zh) 2018-09-28
CN108603998B true CN108603998B (zh) 2021-12-31

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CN201680081622.9A Active CN108603998B (zh) 2015-12-16 2016-12-14 通过确定最优扫描轨迹获取载玻片上的样本的聚焦图像的方法、系统和产品

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US (2) US10761310B2 (https=)
EP (1) EP3391116A1 (https=)
JP (1) JP7146635B2 (https=)
CN (1) CN108603998B (https=)
WO (1) WO2017102827A1 (https=)

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CN107515454B (zh) * 2017-08-29 2019-12-20 宁夏巨能机器人股份有限公司 一种3d视觉定位的焦距自动调节装置及其调节方法
CN108596878B (zh) * 2018-03-30 2021-04-09 浙江大学山东工业技术研究院 图像清晰度评价方法
US10341551B1 (en) * 2018-05-21 2019-07-02 Grundium Oy Method, an apparatus and a computer program product for focusing
US11763461B2 (en) * 2018-06-15 2023-09-19 Siemens Healthcare Diagnostics Inc. Specimen container characterization using a single deep neural network in an end-to-end training fashion
CN112689763B (zh) 2018-09-20 2024-09-20 美国西门子医学诊断股份有限公司 用于样本分类的假设与验证网络和方法
US10896316B2 (en) * 2019-02-04 2021-01-19 Tokitae, LLC Automated microscopy scanning systems and methods
WO2021086720A1 (en) 2019-10-31 2021-05-06 Siemens Healthcare Diagnostics Inc. Methods and apparatus for automated specimen characterization using diagnostic analysis system with continuous performance based training
EP4052162B1 (en) 2019-10-31 2024-08-14 Siemens Healthcare Diagnostics, Inc. Methods and apparatus for protecting patient information during characterization of a specimen in an automated diagnostic analysis system
JP7458481B2 (ja) 2019-10-31 2024-03-29 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 自動診断分析システムにおいて検体のｈｉｌｎ決定に使用される訓練画像をハッシュおよび検索するための方法および装置
CN111275016B (zh) * 2020-03-03 2023-05-16 湖南国科智瞳科技有限公司 一种玻片扫描影像采集与分析方法及装置
US12301990B2 (en) 2020-08-07 2025-05-13 Nanotronics Imaging, Inc. Deep learning model for auto-focusing microscope systems
WO2022043289A1 (en) * 2020-08-25 2022-03-03 F. Hoffmann-La Roche Ag Computer-implemented method for quality control of a digital image of a sample
KR20220157196A (ko) 2021-05-20 2022-11-29 삼성전자주식회사 이미지 처리 방법 및 그 전자 장치
US12548157B2 (en) * 2023-05-16 2026-02-10 Pramana, Inc. Systems and methods for inline quality control of slide digitization
US12217520B1 (en) 2024-06-07 2025-02-04 Pramana, Inc. Apparatus and method for detecting content of interest on a slide using machine learning
US12462431B1 (en) * 2025-05-16 2025-11-04 Pramana, Inc. System and method for automated calibration for a scanning system

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US20110025880A1 (en) * 2009-08-03 2011-02-03 Genetix Corporation Fluorescence imaging

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US7518652B2 (en) * 2000-05-03 2009-04-14 Aperio Technologies, Inc. Method and apparatus for pre-focus in a linear array based slide scanner
US7155049B2 (en) * 2001-01-11 2006-12-26 Trestle Acquisition Corp. System for creating microscopic digital montage images
JP4544850B2 (ja) * 2002-11-29 2010-09-15 オリンパス株式会社 顕微鏡画像撮影装置
US7417213B2 (en) * 2005-06-22 2008-08-26 Tripath Imaging, Inc. Apparatus and method for rapid microscopic image focusing having a movable objective
DE102005040827A1 (de) 2005-08-25 2007-06-21 Carl Zeiss Jena Gmbh Verfahren zur Kompensation des Farblängsfehlers der Abbildungsoptik eines Mikroskops
HUP0600435A2 (en) * 2006-05-26 2007-11-28 3Dhistech Kft Method and system for digitizing a specimen having fluorescent target points
WO2015007697A1 (en) * 2013-07-18 2015-01-22 Ventana Medical Systems, Inc. Auto-focus methods and systems for multi-spectral imaging

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Also Published As

Publication number Publication date
JP7146635B2 (ja) 2022-10-04
WO2017102827A1 (en) 2017-06-22
JP2019505836A (ja) 2019-02-28
CN108603998A (zh) 2018-09-28
US20180292638A1 (en) 2018-10-11
US20200355903A1 (en) 2020-11-12
EP3391116A1 (en) 2018-10-24
US10761310B2 (en) 2020-09-01
US10921575B2 (en) 2021-02-16

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