CN108601803A - Composition is for reducing the purposes of the cholesterol levels of mammal, preparation method, composition and the method for being used to prepare the food additives comprising the composition - Google Patents
Composition is for reducing the purposes of the cholesterol levels of mammal, preparation method, composition and the method for being used to prepare the food additives comprising the composition Download PDFInfo
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- CN108601803A CN108601803A CN201680081493.3A CN201680081493A CN108601803A CN 108601803 A CN108601803 A CN 108601803A CN 201680081493 A CN201680081493 A CN 201680081493A CN 108601803 A CN108601803 A CN 108601803A
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- lignan
- alcohol
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- acid
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019327 succinylated monoglyceride Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000001797 sucrose acetate isobutyrate Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
Abstract
The present invention relates to the compositions comprising the 1 50 wt% ranges preferably lignan mixture of 5 50 wt% ranges for reducing the purposes of the serum cholesterol level of mammal and the method for being used to prepare the composition, the lignan mixture includes aliphatic acid, resin acid, lignan and oligolignans, and wherein lignan includes at least following lignan:7 hydroxyl martairesinols, conidendrin, lariciresinol, liovil, Secoisolariciresinol or its geometric isomer or its stereoisomer, and the 10 50% of the total weight that the amount of wherein oligolignans is the lignan mixture.
Description
The present invention relates to the compositions according to claim 1 comprising lignan mixture for reducing the blood of mammal
The purposes of liquid cholesterol levels.
The group of serum cholesterol level the invention further relates to preparation according to claim 12 for reducing mammal
The method for closing object.
Moreover, it relates to the group for including the lignan mixture of the cholesterol levels for reducing mammal
Close object.
The invention further relates to preparations according to claim 25 for reducing the serum cholesterol level of mammal
Food additives, dietary supplements or dietetic product method.
In food product field, persistently needed for there is the new dietary supplements of advantageous effect to exist human health
It asks.The fact that demand is on the one hand due to food product usually from so-called ready-to-eat product, it is many required to lack
Nutrient and may extraly include modified fat acid (so-called trans-fatty acid to serum triglyceride level and contains
Measurer has unfavorable effect).On the other hand, a large amount of modern diets include food product (meat, milk, butter, cheese based on animal
Deng), it includes have unfavorable effect to blood triglyceride content and increase the saturated fats of blood cholesterol levels.
Plant lignan is main diet phytoestrogen source in modern diet.Phytoestrogen has multiple beneficial
Health effect;High-caliber lignan can support for example healthy glucose metabolism and reduce insulin sensitivity.When as diet
It is also proposed to be used in treatment nonspecific infection and inflammation when replenishers (referring to US 5762935).
However, plant include such low-level lignan so that its health effect in normal meals almost it is micro- not
Sufficient road.The lignan content of food is generally relatively low, typically not greater than 2 mg/100 g.
Timber lignan is very abundant in wooden material and bark, therefore is contemplated that with side identical with plant lignan
Formula uses these lignans in diet.It has been proposed that timber lignan is used in food based on its antioxidant effect, and
Have been found that some scientific and effective anticancers of timber lignan.However, timber lignan and the extract comprising timber lignan lead to
Often bitter for dark and aftertaste, this actually prevents it as the purposes of food additives.
Timber lignan is only used for cosmetic field for these reasons, which is based primarily upon its anti-oxidant and anti-micro- life
Object acts on.For example, applicant has previously been provided for various cosmetics to enhance the protectant effects of the UV wherein used and peace
Some timber lignan mixtures of full property.
Based on the above-mentioned prior art, task is arranged to study the purposes of timber lignan, especially in the present inventor
Purposes in diet, for obtaining new healthy food product.
Therefore, main target of the invention is to find the new application of timber lignan.
The second target of the present invention is the new application for finding timber lignan, although some are negative in terms of its color and taste
Surface properties.
The third target of the present invention be discovery be used to prepare as food additives and Food grade components based on the wooden phenol
The straightforward procedure of the ingredient of element, the ingredient can be added in food product.
These and other target and feature of the present invention will be apparent from following description and claims.
First, the present invention is based on very surprising observation results, that is, when the certain wood for including at least following lignan
When phenol element mixture is used as the dietary supplements of mammal, these lignan mixtures have the blood cholesterol levels of highly significant
Reducing effect:7- hydroxyls-martairesinol, conidendrin, lariciresinol, liovil and Secoisolariciresinol or its is several
What isomers or its stereoisomer.The concentration of lignan mixture should be the 1-50 of the compound as food additives
wt %.The preferably 5-50 wt % of the total weight of a concentration of food additives of lignan mixture.
Due to its considerable blood cholesterol levels reducing effect, timber lignan mixture can be used with relatively small amount;
Normal daily diet part of lignan mixture is 30-50 mg.Include 1-5% lignan mixtures when lignan mixture is used as
Alcohol-wood extractive or alcohol-water-wood extractive in use, it is positively retained at down to 5-10 drops per consumption per day.
The present invention is very astonishing, because timber lignan combination is not known to have any blood cholesterol levels effect simultaneously
And due to compared with known plant lignan the effect be unapproachable;The daily diet of most mankind includes plant wood phenol
Element has property similar with timber lignan, such as antioxidant properties.However, the level of lignan is in edible plant
It is usually very low in object, therefore its possible beneficial cholesterol lowering effect not yet occurs, and plant lignan is in food
Suggestion in additive uses horizontal also relatively high.
Second, the present invention is based on following facts:Lignan, the tannins for including in phenolic compound, such as wooden material
It is extracted from timber with flavonoids Extraction medium, original sample is suitable for various food products.Extraction medium can be extraction solution or
Subcritical or means of supercritical extraction fluid, such as CO2.In the previous practice in this field, lignan, tannins and flavonoids are being incited somebody to action
It is used to before food industry purify.
Different from the practice that described this field is previous, the present invention is based on following facts:Original extraction solution or extraction fluid
It is not purified before.Original extraction solution-wood extractive or original extraction fluid-wood extractive are from wooden material, example
Such as the sawdust of chemical pulp industry or the wood pulp recycling of fragmentation, it includes lignan and/or flavonoids and/or tannins conducts
Then active constituent is used to prepare various food products, food additives or the semi-finished product that can be used in food product as former state.
If food product, food additives or can be used for semi-finished product in food product has that improves to be originated from timber material
The level of the lignan mixture of material is regarded as that method through the invention produces or it is regarded as the food of the present invention
Product product, food additives or semi-finished product, the lignan mixture include 10-50 % of few lignan.
If the composition of the present invention is the solution for including extracting liq-wood extractive, in lignan mixture
The relative quantity of active constituent can be changed to better adapt to the purposes of design.For example, this can by be classified separating extraction program into
Row.Solvent as extraction solution can be based simply on it and adaptability further used is selected.
This provides following advantage:From wooden material separation original extraction solution-wood extractive or original extraction fluid-wood
Material extract is simple and needs process stage than suitable peanut in the past.
Original extraction solution alcohol-wood extractive can be that the mixture of species, such as cloud are set derived from two or more
China fir and pine tree or coniferous tree and birch.Timber may originate from the tree for belonging to Picea or Abies.Timber can particularly be derived from dragon spruce
Species (Picea sp.), Chinese hemlock spruce species (Tsuga sp.) (Chinese hemlock spruce) or Acacia species (Acacia sp).In addition may be used
It uses birch species (Betula sp.).The type and amount of the lignan obtained from different wood species are quite different.
By the way that the lignan from other wood species or plant is added, lignan mixture (=active constituent) can be changed
Effect.
Third, the present invention is based on following facts:The active constituent of selection incorporation food additives or Food grade components should be as
This, which is designed so as to it, can influence different human body parts.Human body includes different polarity, semi-polarity and nonpolar moiety, organ
And film.Given activity ingredient is by diffusing into human body parts, organ depending on its concentration.If there is only it is a kind of activity at
Point, have will limit its by a concentration.Therefore active constituent should include the mixture of various lignans, respectively have
Different polarity and concentration.Need the example with the different physical targets of the active constituent of different migrations (concentration):Cell
Wall (semi-polarity), outside, water phase (polarity) and hydrophobic (wrapping fatty body part).
The lignan of the present invention seems to reduce cholesterol levels by preventing vascular inflammation.If the wooden phenol of only a kind of purifying
Plain compound is used as active constituent, then its migration to the vascular wall of body different location will be more mixed than the active constituent of the present invention
Close object (=lignan mixture) much weaker.
Therefore, invention according to claim 1 is related to lignan mixture for reducing the serum of mammal such as people
The purposes of cholesterol levels.
More accurately, the present invention relates to the lignan mixtures for including 1-50 wt % ranges preferably 5-50 wt % ranges
Composition for reducing mammal serum cholesterol level purposes, the lignan mixture include aliphatic acid, tree
Resin acid, lignan and oligolignans, wherein lignan include at least following lignan:7- hydroxyls martairesinol, Chinese hemlock spruce fat
Element, lariciresinol, liovil, Secoisolariciresinol or its geometric isomer or its stereoisomer, and it is wherein low
The amount of poly- lignan is 10-50 % of the total weight of the lignan mixture.
The importance of the present invention further relates to make timber lignan in edible food product with such water
Ping Ke get, so that its concentration is sufficiently high with it is ensured that its beneficial serum cholesterol level reducing effect.Normal timber
Material only includes a small amount of timber lignan and will be lengthy and tedious complicated and invalid from this wooden material manufacture food supplement.
However it has been found that wood bark and to have section timber include these wood phenol of the lignan mixture that refers to of preparations of much higher amount
Element.
Therefore, an importance of the invention is related to using wood bark or has section timber as the source of lignan,
The method for preparing the composition of the serum cholesterol level for reducing mammal.
The packet of serum cholesterol level the invention further relates to production according to claim 12 for reducing mammal
The method of composition containing the lignan mixture.
More accurately, the method for the present invention packet of the composition of the serum cholesterol level for reducing mammal is produced
It includes:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures,
Alcohol-wood extractive or alcohol-water-wood extractive are obtained, and
Possible edible carrier agent is added to the alcohol-wood extractive or alcohol-water-wood extractive.What is produced is described
Composition includes the 1-100 wt % ranges preferably lignan mixture of 5-90 wt % ranges and extraction solution, wherein extracting
The lignan mixture in solution includes aliphatic acid, resin acid, liovil, lignan and oligolignans, wherein the wooden phenol
Element includes at least following lignan:7- hydroxyls martairesinol, conidendrin, lariciresinol, Secoisolariciresinol or
Its geometric isomer or its stereoisomer, and the amount of wherein oligolignans or its geometric isomer or its stereoisomer
For 10-50 % of the total weight of the lignan mixture present in the composition, wherein extraction solution be selected from alcohol and
Water-alcohol mixture, remainder are physiologically acceptable carrier agent.
The percentage ranges that lignan mixture provides are meant to be based on total composition, percentage by weight.
Lignan herein means the normal dimerization lignan as defined in IUPAC 2000.In addition, liovils exists
It is included in lignan herein.There are three dimerization lignan tools or four benzene oxide units.
Oligolignans, also referred to as few lignan are trimerization or more advanced lignan.Oligolignans are defined on
It is identical as being presented in IUPAC 2000 herein.This is it is meant that oligolignans can be sesquialter lignan, two lignans, two
Sesquialter-, three-, three sesquialters (sesquar)-, four-and five lignans.Such as the lignan of trimerization, so-called sesquialter lignan, tool
There is additional guaiacyl glycerol unit to be bound to a phenol unit of lignan.
Resin acid be mostly those of derived from Pinus timber, and include palustric acid, abietic acid, dihydroabietic acid, pimaric acid,
Sandaracopimaric acid (sandsrocopimaric acid), isodextropimaric acid, neoabietic acid and abietinal (abietal).Most common tree
Resin acid is abietic acid and dehydroabietic acid, is typically found in the timber of Pinus species.
The percentage ranges (wt %) provided for lignan mixture mean based on overall product composition, by weight
Percentage.
The invention further relates to the food additives of the serum cholesterol level for reducing mammal, dietetic product or meals
Eat replenishers.
More accurately, the present invention relates to prepare for reducing mammal serum cholesterol level food additives,
The method of dietary supplements or dietetic product, wherein the method includes the following steps:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures, is carried for obtaining alcohol-timber
Object or alcohol-water-wood extractive are taken,
Possible edible solid or liquid-carrier agent is added to the alcohol-wood extractive or alcohol-water-wood extractive
Such as oily or liquid, aqueous or lotion, and
Mixing alcohol-the wood extractive or alcohol-water-wood extractive, together with food additives, dietary supplements or nutrition
The possible edible carrier agent of product is to prepare edible mixture, to include 1-50 wt-% ranges preferably 5-50
Food additives, dietary supplements or the dietetic product of the lignan mixture of wt-% ranges, the lignan mixture include
Aliphatic acid, resin acid, lignan and oligolignans, wherein lignan include at least following lignan:7- hydroxyl arhat rosin
Element, conidendrin, lariciresinol, liovil, Secoisolariciresinol or its geometric isomer or its stereoisomer, and
And 10-50 % of the total weight that the amount of wherein oligolignans is the lignan mixture.
The preferably described food additives, dietary supplements or dietetic product include 1-90 wt % ranges preferably 5-90
The lignan mixture of wt % ranges is combined with the extraction solution selected from alcohol and water -ol mixture, and remainder is edible
Solid or liquid carrier materials.
The action spectrum of lignan mixture can have anti-micro- lifes for example different from the lignan mixture by being added
The other timber lignans or triterpenes of object efficiency and widen.
Therefore, the invention further relates to further include selected from betulinol, betulonic acid, betulinic acid, betuloinic
The purposes of the composition of the stilbene class or triterpenes of acid, resveratrol and its geometric isomer or its stereoisomer.The present invention
Further relate to corresponding food additives, dietetic product or dietary supplements comprising such stilbene class or triterpenes.
In this regard, finally it is pointed out that lignan mixture itself has antimicrobial efficiency.Therefore, the invention further relates to
Prolong by mixed food material is with food additives comprising the above-mentioned lignan mixture obtained from wooden material
The shelf-life of the long food material.
In addition, the composition of the present invention also may include for example various plant wood phenol of the other lignans obtained from other sources
Element.In addition, composition may include antioxidant such as vitamin or for treat disease or as microbicide substance (from
The betulinic acid or betulinol that birch obtains).When this compound is in food product, new property can get;Its for
Human health is more preferable or it can even help to prevent disease (so-called healthy food).By extracting different types of timber or plant
Object, obtaining has mixture of active principles of different nature, for example, it is anti-oxidant, kill microorganism and possibly, disease prevention and catch
Obtain the ability of free radical.
Known lignan glucosides is metabolized as lignan aglycone and intestines lignan (enterolactone and intestines two by intestinal bacterium
Alcohol) after absorbed in gastrointestinal tract, enterolactone and enterodiol are formed from it.Both enterolactone and enterodiol have shown that with weak
Estrogen and antiestrogenic, and prompted high yield of these antiestrogenic mammalian lignans in intestines can
For protecting women from breast cancer and protection male from prostate cancer.Therefore the composition of the present invention can be further used as pre-
Anti- property composition is to prevent development Cancerous disease.
Food additives are preferably so prepared so that lignan mixture and carrier material form encapsulated liquid, powder together
End or pill.
Usually various oily such as sauce, salad flavouring or marinades are added in the food additives of the present invention
(marinade)。
These food additives can be also mixed into various instant food and ready meal (can extraly be based on meat).These sides
Just food or ready meal are usually including so-called " junk food " such as hamburger, chips, with low-level nutrition
The fat based on meat of plain and a large amount of modified fat acid, so-called trans-fatty acid and/or saturation.Include to refer to by being added
(timber) lignan mixture food additives or dietary supplements, these " junk foods " health some.
No plant lignan or the base with considerably less plant lignan can be also added in the food additives of the present invention
In the food product of plant.These are such as rice, wheaten food, macaroni and bread.
If the food additives of the present invention are added in bread, its health value and its shelf-life can be improved.Latter effect
Fruit is of great significance because increase bread shelf-life will actively impact entirely distribute logic (distribution
logic)。
The food additives of the present invention can also be added in various beverages, fruit juice and nectar.
If it is desired to which food has some bitter tastes, food additives of the invention that can also have advantageous effect.
The lignan mixture preferably used in product of the invention, compound and food additives is by extracting or grinding
Mill coniferous tree (belonging to timber category Picea, Abies, fir or dragon spruce) has section timber to obtain.Such as in Norway spruce (Europe
Continent dragon spruce) in 7- hydroxyl martairesinols be main lignan but other firs/Abies tree include the different larch turpentine of open loop
Plain or lariciresinol is as main lignan (referring also to Knots in trees-A new source of lignans
(section in tree --- new lignan source), Holmbot et al. phytochemistry Reviews 2: 331-340,
2003)。
If the lignan mixture has section timber to obtain from Picea, Abies, fir or dragon spruce, lignan
Mixture has following formula:
- 7- hydroxyl martairesinol 70-80 %;
Conidendrin 3-8 %;
Lariciresinol 1-4 %;
- liovil 2-5 %;
Secoisolariciresinol 3-7 %;
Other lignan 0-3 %;
Few lignan 10-50 %, preferably 20-50 %.
According to the wood source of alcohol-wood extractive, it is also possible to there are other dimerization lignans of significant quantity to be present in each
In alcohol-wood extractive.Such as known pine tree section includes many nortrachelogenins, pinosylvin mono-methyl and rosin element.
According to the source of wooden material, it also may include other timber lignans such as rosin element, nortrachelogenin, sieve
Chinese rosin element and juvabione.
Although diet plant may include that some lignans, the level of lignan are usually very low.
On the other hand, if food compositions are prepared by the way that the composition of the lignan comprising purifying is added, these combinations
Object will not include few lignan or it is horizontal extremely low.
For having section timber and/or bark with extraction solution extraction, for obtaining alcohol-wood extractive or alcohol-water-timber
The various solvents based on alcohol, such as butanediol, butanediol+monohydric alcohol, glycerine or glycerine+alcohol can be used in extract.These are based on
The solvent of alcohol is physiologically acceptable or/and edible.
Extraction solution preferably comprises rudimentary monovalence or divalent alkyl alcohol or rudimentary monovalence and divalent alkyl alcohol and/or sweet
The mixture of oil or the mixture of rudimentary (monovalence) alkylol and divalent or trivalent lower alkyl alcohol.
Monovalent alcohol is preferably ethyl alcohol, propyl alcohol, butanol, enanthol, octanol or decyl alcohol.The particularly preferred ethyl alcohol of monohydric alcohol.
Divalent alkyl alcohol is preferably low-grade alkylidene glycol, is preferably selected from ethylene glycol, propylene glycol, butanediol, pentanediol
And dipropylene glycol.Butanediol is particularly preferred solvent, because the lignan mixture of the present invention is wherein with the amount more than 10%
It dissolves and it is physiologically resistant to.The solution of ethyl alcohol and divalent alcohol is mixed for the lignan for dissolving and extracting the present invention
It is preferred to close object.Divalent alcohol is particularly preferably selected from ethylene glycol, malonyl, butanediol, pentanediol, dipropylene glycol.
Suitable trivalent alcoholic solvent is glycerine.
The mixture of lower alkyl alcohol and glycerine or alkyl diol is preferred solvent medium, this is because different when preparing
Food additives or when food grade compositions, based on the extraction solution comprising this alcohol be further processed original extraction object (=it is molten
Agent+mixture of active principles) or the needs of original extraction object concentrate it is as small as possible.
Original alcohol-wood extractive or alcohol-wood extractive based on alcohol or water-alcohol are very suitable for manufacture Food grade components
Or it uses as former state.These Food grade components include, but are not limited to lotion, dispersion, oil, sweetener.
The lignan mixture of the present invention can be used as alcohol-wood extractive or alcohol-water-wood extractive is added to by these
Various food additives or food grade compositions made of extract.
Food additives are selected from feed ingredient, food supplement and the food additives for direct mankind consumption.
Food supplement includes the vitamin and mineral replenishers such as capsule, tablet, powder, molten of unit dosage form
Liquid etc..This page is provided for using information as defined in acceptable food additives in the food for meeting food classification.Wherein
The comprehensive list of the possible food supplement of the lignan mixture of the present invention can be used to be in GSFA online food classification
It is existing.
Feed ingredient is addition feed and constitutes the composition part of feed or component or any combinations/mixture.Feed at
Divide and may include cereal, byproduct of milling, the vitamin of addition, minerals, fats/oils class and other nutrition and energy source.It raises
Expect that the comprehensive list of ingredient (is raised in the U.S. in Association of American Feed Control Officials
Material supervision official association) (AAFCO) official publications in present.
It wherein may include the comprehensive list of the food additives of the lignan mixture of the present invention in CFR regulations allusion quotation collection
It is presented in 21st (CFR Code of Regulations Title 21).These include food preservative (subdivision A), food
Product coating (subdivision C), special diet and nourishing additive agent (subdivision D), anti-caking agent (subdivision E), flavoring agent and related
Substance (subdivision F), glue, continuous gum base and related substances (subdivision G), are mostly used other particular use additives (subdivision H)
Way additive (subdivision I).
Original alcohol-wood extractive or alcohol-wood extractive based on alcohol or water-alcohol can be mixed into and belong to above and carried
And CFR federal regulations allusion quotations collection the 21st versatile additive (subdivision I) food grade compositions or food additives
Some examples:
172.809 Currdlan.
172.810 dioctyl sodium sulfosuccinate
172.811 glycerol tristearate
172.812 glycine
172.814 hydroxylated lecithin
172.816 methyl glucosamine coconut grease
172.818 oxystearin
172.820 polyethylene glycol (average molecular weight 2009,500)
172.822 lauryl sodium sulfate
172.824 single and dimethylnaphthalene sodium sulfonate
172.826 sodium stearyl fumarate
172.828 acetylated monoglyceride
172.829 neotame
172.830 succinylated monoglycerides
172.831 Sucralose
172.832 citric acid monoglyceride
Sucrose acetate isobutyrate 172.833 (SAIB)
172.834 ethoxylation lists and two glyceride
172.836 polysorbate 60
172.838 polysorbate 65
172.840 polyoxyethylene sorbitan monoleate
172.841 polydextrose
172.842 sorbitan monostearate
172.844 stearoyl -2- calcium lactates
172.846 stearoyl lactate
172.848 the lactoyl ester of aliphatic acid
The lactylated fatty acid esters of 172.850 glycerine and propylene glycol
The glyceryl breast ester of 172.852 aliphatic acid
172.854 the polyglycerol ester of aliphatic acid
The propylene glycol list and diester of 172.856 fat and aliphatic acid
172.858 propylene glycol alginate
172.859 sucrose fatty ester
172.860 aliphatic acid
172.861 coconut oil, palm-kernel oil or two kinds of oily cocoa butter substitutes
172.862 the oleic acid derived from ready denier oil acid
172.863 fatty acid salt
172.864 the fatty alcohol of synthesis
The 172.866 synthetic glycerine generated by hydrogenolysis carbohydrate
The lignan mixture of the present invention can also be mixed with carrier or extraction solution, be food additives appropriate.Lignan
Mixture can be powder or alcohol-water-wood extractive or alcohol-wood extractive.
The comprehensive list of these carriers or Extraction solvent can be (strong from health Canada, Food and Nutrition
Health Canada, food and nutrition) it finds.These carriers or Extraction solvent include following:Acetone, benzyl alcohol, 1,3 butylene glycol, two
Carbonoxide, castor oil, the citrate of list and two glyceride, ethyl acetate, ethyl alcohol, glycerine (glycerine), diacetine,
Glyceryl triacetate, tributyrin, hexane, isopropanol, methylol, methyl ethyl ketone (2- butanone), dichloromethane, Dan He
Two glyceride, citric acid monoglyceride, 2- nitropropanes, 1,2- propylene glycol (1,2-propylene glycol, 1,2-
Propanediol the propylene glycol monoester and diester, triethyl citrate of the aliphatic acid of fat), are formed.
Embodiment
Embodiment 1
Including alcohol-wood extractive of the concentration of following lignan mixture is broken by being extracted with the extraction solution comprising propylene glycol
The European spruce split has section timber to prepare.The lignan mixing that the lignan extract is presented in the table 1 comprising 7.5 wt-%
Object:
Alcohol-wood extractive of several other concentrations is carried also by with the extraction solution comprising butanediol, pentanediol or glycerine
The European spruce of fragmentation is taken to have section timber to prepare.Present in these alcohol-wood extractives extracted in being saved from European spruce most
Important lignan is identical as what is presented in table 1, and (Liovil is actually not lignan, but it is included in table 1 herein
In).
Table 1
Lignan | Amount, % W |
Hydroxyl martairesinol | 5-6 |
Secoisolariciresinol | 0.2-0.4 |
Conidendrin | 0.2-0.4 |
Liovil | 0.2-0.4 |
Lariciresinol | 0.1-0.2 |
Other lignans | 0.2-1 |
As can be seen from Table 1, there are great changes, alcohol-timber extraction for the lignan composition between extract and extract
The amount of " other lignans " can quite significantly in object.
In alcohol-wood extractive of Fig. 1, main wooden material (timber section) source is European spruce, but is also mixed
The wooden material (timber section) from pine tree of significant quantity, this is also introduced in the alcohol-wood extractive except shown in table 1
Other lignans other than those.
The composition of lignan mixture is best understood from order to obtain, by these timber -ol extracts further by making
It is analyzed with several chromatographic processes.The composition of lignan mixture is first by using gas-chromatography side present in these extracts
Method is analyzed, and is as a result shown in fig. 1-3.Internal reference is betulinol.
It was found that in addition to the about 56% normal dimerization lignan (hydroxyl martairesinol, the different larch of open loop that are presented in table 1
Fat element, conidendrin, lariciresinol) except, actually each timber -ol extract may also comprise about 10-50 % usual 20
The few lignan of -50 % and the resin acid and aliphatic acid of 1-4 %.As previously mentioned, although Liovil itself is not considered as lignan
(referring to the lignan in IUPAC 2000), it is simple in order to quote, it is considered a part for lignan mixture here.
Fig. 1 shows the result of the HPLC analyses of timber -ol extract (Norway spruce, with pine part).In embodiment
In then will the extract be added various products in.The sawdust for having section timber from Norway spruce is carried with alcohol (ethyl alcohol) first
It takes, HPLC analyses is used in combination to identify most important compound from timber -ol extract.Internal standard is birch in HPLC analyses
Alcohol.
As can be from seeing Fig. 1, the timber -ol extract of analysis includes aliphatic acid, resin acid, normal lignan and oligomeric
Lignan (few lignan).The non-depth of few lignan (oligolignans) is qualitative, but the part seems comprising at least sesquialter wood phenol
Element and two lignans and two sesquialters-, three-, three sesquialters-and four lignans, four lignan esters and five lignans (these few wooden phenol
The definition and structure of element are identical as being presented in IUPAC 2000).It is most abundant for two lignans, sesquialter lignan and two sesquialters
Lignan.
Fat and resin acid and normal lignan are further analyzed by HPLC, are as a result shown in figs 2 and 3.Below
The general introduction of result and discussion is presented.
Resin acid be mostly derived from Pinus timber and include palustric acid, abietic acid, dihydroabietic acid, pimaric acid, mountain reach Korean pine
Acid, isodextropimaric acid, neoabietic acid and abietinal (abietal).However, most abundant resin acid is abietic acid and dehydroabietic acid, it is
Typical resins present in the timber of Pinus species.
Resin acid includes some resin acids such as pinosylvin methyl esters derived from pine.
Lignan includes mainly 7- hydroxyl martairesinols, but there are the martairesinol of significant quantity, different hydroxyl podocarpus
Fat element, different fallen leaves pine camphor (isolaricinol), lariciresinol, conidendrin, conidendrin acid, Secoisolariciresinol
With liovil (todolactol).Liovil is actually not lignan.Since wooden material includes the pine tree timber of trace,
There is also rosin elements.
Embodiment 2
Including alcohol-wood extractive of the concentration of the lignan mixture presented in table 1 is by with the extraction for including second alcohol and water
The European spruce of solution extraction fragmentation has section timber to prepare.What alcohol-water-wood extractive was presented in the table 1 comprising 75 wt %
Lignan mixture.
Alcohol-wood extractive of the concentration can as former state use in preparing various alcoholic beverage.Each beverage may include example
As 10 g include above-mentioned alcohol-water-wood extractive of 75 wt % lignan mixtures.Preferred alcoholic beverage is with a little
Those of taste after hardship, such as gin tonic.
Embodiment 3
Food additives are prepared for, it includes two glyceric acid of caprylic/capric list (CAS 85536-07-8) of 80 wt % and 20
Alcohol-water-the wood extractive prepared in the embodiment 2 of wt %.Therefore food additives include the lignan of 15 wt % of its dry weight
Mixture.Lignan mixture present in food additives has the wooden phenol identical with the lignan mixture referred in table 1
Element composition.The lignan mixture has the oligolignans of about 25-46 %, remaining is oligolignans shown in Fig. 1,
Aliphatic acid and resin acid.
Embodiment 4
Alcohol composition (liquid) by mix 10 weight % according to embodiment 1 prepare lignan extract and 90 weight % 1,
It is prepared by 3-propanediol (Zemea, Dupont-Tate-Leyle).The composition gives patient, 5-10 drops/day daily.
Table 2
As a result:
From result it is clear that dripping composition using daily 5, after continuing 3-12 months periods, cholesterol, LDL, HDL and sweet
Oily three ester levels significantly reduce.
Embodiment 5
Other food additives mentioned above can be prepared in a manner of corresponding with embodiment 3.Lecithin can be used as dispersant.
Embodiment 6-xx
Food additives, dietary supplements or the nutraceutical of following exemplary are prepared when providing it lignan mixture.
Embodiment 6a
Prepare nutrition milk product
Milk, cheese, cream, the French whipping cream (creme of the milk product of timber lignan enhancing such as timber lignan enhancing
Fraiche), ice cream, Ke Feier Yoghourts (kefir), smetana, yogurt, Yoghourt and curdled milk (viili) can by directly to
The solution comprising timber lignan is simply added in the milk product of finished product or semi-finished product to prepare.
The preparation of the milk product of enhancing can carry out as follows:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures, for obtaining alcohol-timber extraction
Object or alcohol-water-wood extractive;
Physiologically acceptable carrier agent is mixed into the alcohol-wood extractive or alcohol-water-wood extractive, to obtain
Comprising alcohol-wood extractive together with carrier agent or alcohol-water-wood extractive together with the mixture of carrier agent;
Mix the mixing of the mixture or alcohol-water-wood extractive and carrier agent of the alcohol-wood extractive and carrier agent that obtain
Object and milk product.
The mixture or the mixture of alcohol-water-wood extractive and carrier agent of alcohol-wood extractive and carrier agent may include
Lignan mixture 50-90 wt % (are calculated) according to the mixture.The mixture is added with about 5-15 g/100 g milk products
Enter.
The Yoghourt prepared from original flavor milk usually has following composition:
The conventional ingredient (proximates) of every 100 g Yoghourts
87 g of water
61 kcal of energy
3.47 g of protein
3.25 g of total lipid (fat)
466 g of carbohydrate
Fiber, 0 g of total diet
4,66 g of total reducing sugar
Minerals
Calcium, 121 mg of Ca
Iron, 0.05 mg of Fe
Magnesium, 12 mg of Mg
Phosphorus, 95 mg of P
Potassium, 155 mg of K
Sodium, 46 mg of Na
Zinc, 0.59 mg of Zn
Vitamin
Vitamin C, 0.5 mg of total ascorbic acid
0.029 mg of thiamines
0.142 mg of riboflavin
0.075 mg of niacin
0.032 mg of vitamin B-6
Folic acid, 7 ug of DFE
0.37 mg of vitamin B-12
Vitamin A, 27 ug of RAE
Vitamin A, 99 IU of IU
0.06 mg of vitamin E (alpha-tocopherol)
Vitamin D (D2+D3) 0.1 ug
2 IU of vitamin D
0.2 ug of vitamin K (phylloquinone)
Lipid
Aliphatic acid, 2.0 g being always saturated
Aliphatic acid, total monounsaturated 0.89 g
Aliphatic acid, 0.09 g of total how unsaturated
13 mg of cholesterol
Timber lignan(table 1) 5 g
Equally, other liquid or semiliquid milk product have minerals, vitamin, lipid and routine similar or be almost similar
The composition of ingredient (proximates).Milk product does not include the lignan of any timber source or even plant source.Therefore, any breast
All timber lignans present in product are introduced by mixing timber lignan into the milk product.
Embodiment 6b
Volume, hamburger with timber lignan or hot dog
The timber lignan with cholesterol lowering effect can be provided to hamburger, volume and similar products.
The classical nutritional value of every 100 g hamburgers:
Conventional ingredient
34.34 g of water
Energy 279
9.77 g of protein
Total lipid (fat) 3.91
50.12 g of carbohydrate
1.8 g of fiber
7.28 g of total reducing sugar
Vitamin
1.3 mg of vitamin C
0.543 mg of thiamines
0.297 mg of riboflavin
4.180 mg of niacin
0.063 mg of vitamin B-6
Folic acid, 131 ug of DFE
0.20 ug of vitamin B-12
Vitamin A, 29 ug of RAE
Vitamin A, 107 IU of IU
0.27 mg of vitamin E
0 IU of vitamin D
4.8 IU of vitamin K
As that can arrive as seen from above, typical composition usually load carbohydrate and the fat of hamburger, volume and similar products.It is logical
15-30 g/ products of addition timber lignan are crossed, these products can be made slightly healthy, or although consume these products but extremely
It can control the cholesterol levels of people less.
These products can be prepared for example as follows:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures,
Alcohol-wood extractive or alcohol-water-wood extractive are obtained, it includes 1-90 wt-% ranges preferably 5-50 to have
The composition of the lignan mixture of wt-% ranges, the lignan mixture include aliphatic acid, resin acid, lignan and oligomeric wood
Phenol element, wherein lignan include at least following lignan:7- hydroxyls martairesinol, conidendrin, lariciresinol,
The amount of liovil, Secoisolariciresinol or its geometric isomer or its stereoisomer and wherein oligolignans is institute
10-50 % of the total weight of lignan mixture are stated,
Mix the meat ground of the alcohol-wood extractive obtained or alcohol-water-wood extractive and hamburger, volume etc..
Embodiment 6C
Salad flavouring
The composition of the present invention can be by being added with suitable food grade compositions or aforementioned food additives (see, for example, CFR
The versatile additive (subdivision I) that federal regulations allusion quotation collection is the 21st) mixing alcohol-wood extractive and any salad tune is added
In taste product.
Embodiment 6D
Caramel
Manufacturing a part of sugar of caramel can be replaced with the composition of the present invention, and it includes 1-100 wt-% ranges preferably 5-90
The lignan mixture of wt-% ranges.The composition can for alcohol extracting thing itself that such as table 1 is presented or its can be alcohol composition
Or original alcohol-wood extractive based on water-alcohol or suitable food grade compositions or aforementioned food additives are mixed (referring to example
Such as, the versatile additive (subdivision I) of CFR federal regulations allusion quotation collection the 21st) alcohol-wood extractive.The combination of the present invention
Object can be added before or after heating caramel ingredient.
Embodiment 6E
Pill
Pill can be tablet or capsule, can in a usual manner be manufactured from food additives, dietary supplements or dietetic product.Example
Such as, when manufacturing tablet, the present composition can be added in food additives, dietary supplements or dietetic product, then will
Its powdered or granulating.The powder or particle are mixed with suitable adhesive such as sucrose, lactose, cellulose,
Tablet is manufactured from the mixture by suppressing.
Claims (38)
1. the composition comprising the 1-50 wt % ranges preferably lignan mixture of 5-50 wt % ranges is for reducing lactation
The purposes of the serum cholesterol level of animal, the lignan mixture include aliphatic acid, resin acid, lignan and the oligomeric wooden phenol
Element, wherein lignan include at least following lignan:7- hydroxyls martairesinol, conidendrin, lariciresinol, liovil,
Secoisolariciresinol or its geometric isomer or its stereoisomer, and the amount of wherein oligolignans is the wooden phenol
The 10-50% of the total weight of plain mixture.
2. the purposes of the composition of claim 1, wherein oligolignans are few lignan, include at least two sesquialter lignans,
Sesquialter lignan and two lignans.
3. the purposes of the composition of claim 1, the composition includes additionally sterol such as sitosterol or sitostanol.
4. the purposes of the composition of claim 1, wherein lignan mixture also include pinosylvin resin acid.
5. the purposes of the composition of claim 1, wherein lignan mixture also include rosin element.
6. the purposes of the cholesterol levels for reducing mammal of the composition of claim 1, wherein lignan mixture
The one or more lignans for also including 0.1-10 wt % ranges, are selected from:Rosin element, nortrachelogenin, arhat rosin
Element, juvabione or its geometric isomer or stereoisomer and few lignan.
7. the purposes of the composition of claims 1 or 2, for reducing the cholesterol water of mammal by preventing vascular inflammation
It is flat.
8. the purposes of the composition of claim 1, wherein the composition is further included selected from betulinol, betulonic acid, birch
The stilbene class or triterpenes of wood acid, betuloinic acid, resveratrol and its geometric isomer or stereoisomer.
9. the purposes of the composition of claim 1, wherein the composition further includes vitamin or plant lignan.
10. the method for claim 1 wherein the methods extraly including measuring the serum cholesterol level of mammal then
The step of giving the composition for reducing cholesterol levels.
11. the method for claim 10, wherein the amount for reducing the composition of serum cholesterol level is surveyed in cholesterol levels
It is defined on the basis of amount result.
12. the method for generating the composition of the serum cholesterol level for reducing mammal, wherein the composition passes through
It prepares below:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures,
Alcohol-wood extractive or alcohol-water-wood extractive are obtained, and
Possible edible carrier agent is added to the alcohol-wood extractive or alcohol-water-wood extractive,
The wherein described composition includes the 1-100 wt % ranges preferably lignan mixture of 5-90 wt % ranges and extracts molten
Liquid, wherein the lignan mixture in extraction solution includes aliphatic acid, resin acid, liovil, lignan and the oligomeric wooden phenol
Element, wherein lignan include at least following lignan:7- hydroxyls martairesinol, conidendrin, lariciresinol, open loop is different falls
Leaf rosin element or its geometric isomer or its stereoisomer, and wherein oligolignans or its geometric isomer or its solid
The amount of isomers is the 10-50% of the total weight of the lignan mixture present in the composition, wherein extraction solution choosing
From alcohol and water -ol mixture, remainder is physiologically acceptable carrier agent.
13. the method for claim 12 includes the lignan mixture of the preferred 5-80 wt % ranges of 1-80 wt % ranges, institute
It includes at least following lignan to state lignan mixture:7- hydroxyls martairesinol, conidendrin, lariciresinol, liovil
It is oligolignans, at least with Secoisolariciresinol or its geometric isomer or stereoisomer and few lignan
Including two sesquialter lignans, sesquialter lignan and two lignans.
14. the method for claim 12, wherein the composition includes the wooden phenol of 5-50 wt % preferably 1-10 wt % ranges
Plain mixture.
15. the method for any one of claim 12-14, wherein lignan mixture also include the choosing of 0.1-10 wt% ranges
From rosin element, nortrachelogenin, martairesinol, juvabione and few lignan and its geometric isomer or its stereoisomer
One or more lignans.
16. the method for any one of claim 12-15, wherein extraction solution includes alcohol, it is lower monovalent alcohols, rudimentary divalent
Or mixtures thereof alkylol or rudimentary trivalent alcohol.
17. the method for claim 16, wherein divalent alcohol are selected from propylene glycol, butanediol and pentanediol and trivalent alcohol is glycerine.
18. the method for claim 12, wherein extraction solution include monovalent lower alcohol such as ethyl alcohol and/or, bivalent lower alcohol example
Such as propylene glycol and/or trivalent Lower alcohols such as glycerine.
19. the method for claim 12, wherein having section timber to be derived from is selected from Picea (Picea), Abies (Abies) or Chinese hemlock spruce
Belong to the coniferous tree of (Tsuga).
20. the method for claim 12, wherein there is section timber derived from European spruce (Picea abies), Chinese hemlock spruce (Hemlock object
Kind) or derived from wattle (Acasia tree).
21. the method for claim 12, wherein concentration of the lignan mixture in the composition of preparation is as follows:
- 7- hydroxyl martairesinol 70-80 %;
Conidendrin 3-8 %;;
Lariciresinol 1-4 %;
- liovil 2-5 %;
Secoisolariciresinol 3-7 %;
Oligolignans 0-3 %.
22. the method for claim 12, wherein the composition further include selected from betulinol, betulonic acid, betulinic acid,
The triterpenes or stilbene class of betuloinic acid and resveratrol or its geometric isomer or its stereoisomer.
23. the method for claim 12, wherein the composition further includes vitamin or plant lignan.
24. the composition prepared according to the method for any one of preceding claims 12-23.
25. preparing food additives, dietary supplements or the dietetic product of the serum cholesterol level for reducing mammal
Method, wherein the method includes the following steps:
There are section timber and/or bark with the extraction solution extraction selected from alcohol and alcohol-aqueous mixtures, for obtaining alcohol-timber extraction
Object or alcohol-water-wood extractive,
Possible edible solid or liquid-carrier agent is added to the alcohol-wood extractive or alcohol-water-wood extractive
Such as oily or liquid, aqueous or lotion, and
Mixing alcohol-the wood extractive or alcohol-water-wood extractive, together with food additives, dietary supplements or nutrition
The possible edible carrier agent of product is to prepare edible mixture, to include 1-50 wt % ranges preferably 5-50
Food additives, dietary supplements or the dietetic product of the lignan mixture of wt % ranges, the lignan mixture include
Aliphatic acid, resin acid, lignan and oligolignans, wherein lignan include at least following lignan:7- hydroxyl arhat rosin
Element, conidendrin, lariciresinol, liovil, Secoisolariciresinol or its geometric isomer or its stereoisomer, and
And 10-50 % of the total weight that the amount of wherein oligolignans is the lignan mixture.
26. the method for claim 25, wherein oligolignans include at least two sesquialter lignans, sesquialter lignan and the two wooden phenol
Element.
27. food additives, diet of the preparation of claim 22 or 25 for reducing the serum cholesterol level of mammal
The method of replenishers or dietetic product, the food additives, dietary supplements or dietetic product include that 1-90 wt % ranges are excellent
The lignan mixture of selection of land 5-90 wt % ranges is combined with the extraction solution selected from alcohol and water -ol mixture, remainder
It is divided into edible solid or liquid carrier materials.
28. the method for any one of claim 25-27, wherein the food additives, dietary supplements or dietetic product,
The wherein described lignan mixture also includes the rosin element, nortrachelogenin, the arhat rosin that are selected from of 0-10 wt % ranges
Element, juvabione and oligolignans and its geometric isomer or the one or more lignans of its stereoisomer.
29. the method for any one of claim 25-28, including to the food additives, dietary supplements or dietetic product
Middle addition is selected from betulinol, betulonic acid, betulinic acid, betuloinic acid, resveratrol and its geometric isomer or it is vertical
The step of stilbene class or triterpenes of body isomers.
30. the method for any one of claim 25-29, including to the food additives, dietary supplements or dietetic product
The step of middle addition vitamin or plant lignan.
31. the method for claim 25, wherein the method further includes from the food additives, dietary supplements or battalion
Support the step of product forms pill or capsule.
32. being prepared according to claim 31 and including food additives, dietary supplements or dietetic product and timber lignan
The pill or capsule of combination.
33. the method for claim 25 further comprises by with anti-oxidant or anti-microbial effect food additives
The step of handling food material and extending the shelf-life of the food material.
34. the method for claim 32 further comprises by taking orally the intestines given in human dietary supplement's increase people's intestines daily
The step of lactone generates.
35. the method for claim 25 further comprises giving human dietary supplement reduction mammal by taking orally daily
The step of risk of cancer.
36. the method for claim 25 further comprises the food additives, dietary supplements or battalion from claim 22
It supports product and manufactures condensed food product.
37. the method for claim 36, wherein the condensed food product is lotion or liquid such as oil, sauce, flavouring, acid
Milk, fruit juice, nectar or beverage.
38. the method for claim 36, wherein the product is solid such as rice, wheaten food, macaroni or meat.
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FI20155934 | 2015-12-09 | ||
PCT/FI2016/050864 WO2017098089A1 (en) | 2015-12-09 | 2016-12-09 | The use of a composition for lowering cholesterol level in a mammal, a method for its preparation, a composition and a method for preparing food additive comprising said composition |
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Country Status (5)
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EP (1) | EP3386524A1 (en) |
CN (1) | CN108601803A (en) |
CA (1) | CA3008075A1 (en) |
MX (1) | MX2018007065A (en) |
WO (1) | WO2017098089A1 (en) |
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EP4007587A4 (en) * | 2019-08-02 | 2023-09-27 | Oy Granula AB LTD | A method and a compound for preventing mammalian cancer cell proliferation and for treating cancer |
CN114831996B (en) * | 2021-04-02 | 2023-09-22 | 贵阳倍隆生物科技有限公司 | Animal feed composition with liver protection effect |
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- 2016-12-09 CN CN201680081493.3A patent/CN108601803A/en active Pending
- 2016-12-09 CA CA3008075A patent/CA3008075A1/en active Pending
- 2016-12-09 WO PCT/FI2016/050864 patent/WO2017098089A1/en active Application Filing
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EP3386524A1 (en) | 2018-10-17 |
CA3008075A1 (en) | 2017-06-15 |
WO2017098089A1 (en) | 2017-06-15 |
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