CN108577827A - A kind of nerve electrode and preparation method thereof - Google Patents
A kind of nerve electrode and preparation method thereof Download PDFInfo
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- CN108577827A CN108577827A CN201810314016.8A CN201810314016A CN108577827A CN 108577827 A CN108577827 A CN 108577827A CN 201810314016 A CN201810314016 A CN 201810314016A CN 108577827 A CN108577827 A CN 108577827A
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- electrode
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- nerve electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
Abstract
The invention discloses a kind of nerve electrodes and preparation method thereof, including basal electrode, specially a kind of seaweed acid gel (Al), multi-walled carbon nanotube (CNT), conducting polymer (CP) nerve electrode and preparation method thereof, have both the electric conductivity of the flexibility and conducting polymer (CP) of seaweed acid gel (Al), biocompatibility is good simultaneously, is tightly combined with basal electrode.Therefore, seaweed acid gel (Al), multi-walled carbon nanotube (CNT), conducting polymer (CP) nerve electrode based on the present invention meet signal sensitivity and the long-term safety requirement of nerve electrode.
Description
Technical field
The invention belongs to novel biomaterial technical field, it is related to a kind of nerve electrode and preparation method thereof, and in particular to
The nerve electrode and preparation method thereof of a kind of seaweed acid gel, multi-walled carbon nanotube, conducting polymer, the nerve electrode modified
With good chemical property and excellent biocompatibility.
Background technology
Nerve electrode records contact circle in site and nerve fiber for recording nerve action potential and signal input, signal
Face situation is the key influence factor of its performance, due to recording the mismatch in site and nerve fiber physical and chemical performance, usually
Cause inflammatory reaction and the electrode failure of nerve fiber, there are skills in signal sensitivity, long-term safety etc. for nerve electrode
Art bottleneck improves electric property, biology performance and the mechanical performance of electrode there is an urgent need for developing new electrode modified material.
The metal material that Signa Gel substitutes nerve electrode record site can not solve the mechanical performance of contact interface not
With problem, to mitigate tissue damage and inflammatory reaction.Compared to metal electrode, Signa Gel (CH) has ion and electronic conduction
Property, safer charge transport properties and the performance preferably combined with biomolecule and drug, but existing drop coating is modified
Method is difficult the dosage and range for controlling Signa Gel on electrode record site, limits its answering in nerve electrode modification
With.And alginic acid hydrogel (Al) can be electrodeposited into metal surface by hydrolysis, be presented in nerve electrode modification
Huge application potential.
But pure alginic acid hydrogel electric conductivity is weaker, can be generally obviously improved by admixing multi-walled carbon nanotube (CNT)
Its electric property, and include conducting polymer (CP) network in hydrogel substrate, forming a kind of percolating network can be further
So that composite material has both the flexibility of hydrogel and the electric conductivity of conducting polymer (CP).Many researchs will be conductive by electropolymerization
Polymer (CP) is incorporated into the material that nerve electrode is modified in seaweed acid gel, and conducting polymer (CP) is only recorded in electrode
Site is assembled with Hydrogel contact position, is not evenly distributed in hydrogel, is limited the electric conductivity of conducting polymer (CP).
Signa Gel (CH) can be further promoted after surface multi-walled carbon nanotube (CNT) of blending coating conducting polymer (CP)
Electric property, while the multi-walled carbon nanotube (CNT) for coating conducting polymer (CP) can be used as electropolymerization conducting polymer
(CP) site so that conducting polymer (CP) is more evenly distributed in CH systems, enhances its electric property.Therefore, it ties
Seaweed acid gel (Al), multi-walled carbon nanotube (CNT) and conducting polymer (CP) is closed to be expected to develop novel nerve electrode modification
The signal sensitivity and long-term safety of material lift electrode.
Invention content
It is an object of the invention in view of the above-mentioned problems, overcome the shortage of prior art, disclose a kind of seaweed acid gel
(Al), the nerve electrode and preparation method thereof of multi-walled carbon nanotube (CNT), conducting polymer (CP), has both seaweed acid gel
(Al) electric conductivity of flexibility and conducting polymer (CP), while biocompatibility is good, is tightly combined with basal electrode.Cause
This, seaweed acid gel (Al), multi-walled carbon nanotube (CNT), conducting polymer (CP) nerve electrode based on the present invention meet god
The requirements such as signal sensitivity and long-term safety through electrode.
To achieve the above object, the present invention uses following technical scheme：
A kind of nerve electrode and preparation method thereof, including basal electrode, the basal electrode surface are equipped with seaweed acid gel
(Al), multi-walled carbon nanotube (CNT), conducting polymer (CP) nanocomposite.
Another object of the present invention is to provide a kind of preparation method of nerve electrode, the preparation method includes：Using
Galvanostatic method is in one layer of conducting polymer of basal electrode surface electro-deposition；By multi-walled carbon nanotube by ultrasonic disperse in PEDOT/
In PSS solution, ultrasonic power 100W, time 8h prepare the solution of conducting polymer (CP) coating multi-walled carbon nanotube (CNT),
Then 1 is pressed with the Al of 2wt%:1 is mixed with seaweed acid gel (Al)/multi-walled carbon nanotube (CNT)/conducting polymer (CP) electricity
Plating solution uses constant voltage method one layer of Al/CNT/CP composite wood of electro-deposition on the electrode of (1) in the Al/CNT/CP electroplate liquids
Material；Electropolymerization conducting polymer later forms a kind of nerve electrode of Signa Gel percolating network modification.
Wherein, the multi-walled carbon nanotube is the multi-walled carbon nanotube of carboxyl modified, 0.5-2 micron of length, diameter 10-20
Nanometer；The conducting polymer monomer is ethene dioxythiophene, is p-methyl benzenesulfonic acid to ion；The conductive polymer solution is
Polyethylene dioxythiophene or p-methyl benzenesulfonic acid；The basal electrode is the nichrome microfilament of tape insulation layer, metal end face diameter
About 30 microns；EDOT concentration 0.1wt%, PSS concentration 0.2wt%, electric current 10nA, time 50s in the galvanostatic method electrolyte；
Al concentration 1wt%, CNT concentration 3mg/mL, voltage 3V, time 2s in the constant voltage method electrolyte；The electropolymerization method electricity
Solve EDOT concentration 0.1wt%, PSS concentration 0.2wt%, electric current 10nA, time 200s in liquid；The electrochemical method, is all made of
Three-electrode system, platinum plate electrode are used as to electrode, and Ag or AgCl are as reference electrode.
Advantageous effect：There is following advantages compared with prior art in the present invention：
(1) the present invention is based on seaweed acid gel (Al), the neuroelectricities of multi-walled carbon nanotube (CNT), conducting polymer (CP)
Pole, which records site, has good flexibility, more matches the mechanical performance of nerve fiber, is conducive to the immune response for reducing tissue
Promote electrode long-term safety.
(2) the present invention is based on seaweed acid gel (Al), the neuroelectricities of multi-walled carbon nanotube (CNT), conducting polymer (CP)
Pole is conducive in the surface multi-walled carbon nanotube (CNT) coating conducting polymer (CP) between reduction multi-walled carbon nanotube (CNT) network
Contact impedance, while providing polymerization site for follow-up electric polymer (CP) electropolymerization in hydrogel, be conducive to electropolymerization
Object (CP) being uniformly distributed in hydrogel promotes the electric property of electrode, and then improves the sensitivity of electrode.
(3) the present invention is based on seaweed acid gel (Al), the neuroelectricities of multi-walled carbon nanotube (CNT), conducting polymer (CP)
Pole substrate is tightly combined with decorative material, compares common drop coating method of modifying, the modification of alginic acid hydrogel (Al) electro-deposition
Method can be good at controlling the dosage and modification range of hydrogel, simplify electrode production process, therefore testing and applying
Aspect reduces cost, has more application value.
Description of the drawings
Fig. 1 is the nerve electrode forming process schematic diagram of the present invention.
Fig. 2 is the magnification at high multiple photo of nerve electrode forming process in the embodiment of the present invention 1：Wherein (A) unmodified micro-
Silk electrode, the fibril electrode of (B) electro-deposition, the fibril electrode after (C) electropolymerization.
Fig. 3 is nerve electrode surface seaweed acid gel, multi-walled carbon nanotube, conducting polymer prepared by the embodiment of the present invention 1
Object composite material electron scanning micrograph.
Fig. 4 is nerve electrode surface seaweed acid gel, multi-walled carbon nanotube, conducting polymer prepared by the embodiment of the present invention 1
Object composite material transmission electron microscope photo
Specific implementation mode
The present invention will be further described below with reference to the drawings.
Embodiment 1：
It please refers to Fig.1, Fig. 2, Fig. 3 and Fig. 4, a kind of preparation method of nerve electrode, as shown in Figure 1, fibril electrode passes through
Conducting polymer (CP) coating is formed after conducting polymer (CP) electro-deposition, using seaweed acid gel (Al)/multi-wall carbon nano-tube
Seaweed acid gel (Al)/multi-walled carbon nanotube (CNT)/conducting polymer is formed after managing (CNT)/conducting polymer (CP) electro-deposition
(CP) coating finally passes through conducting polymer (CP) network that conducting polymer (CP) electropolymerization in gel forms point polymerization.
Detailed process is：The PSS solution 100mL of the EDOT and 0.2wt% of 0.1wt% are prepared, are ultrasonically treated until EDOT
Monomer, which is uniformly dispersed, prepares conducting polymer (CP) electroplate liquid.The multi-walled carbon nanotube (CNT) of 6mg/mL is existed by ultrasonic disperse
In PEDOT/PSS (1.3-1.7wt%) solution, ultrasonic power 100W, time 8h, then by volume with the Al solution of 2wt%
1:1 is mixed with seaweed acid gel (Al)/multi-walled carbon nanotube (CNT) electroplate liquid 100mL.Fibril electrode connects after being cleaned by ultrasonic
The working electrode of electrochemical workstation, platinum plate electrode are used as to electrode, Ag or AgCl as reference electrode, and three-electrode system exists
Electrode modification is carried out in conducting polymer (CP) electroplate liquid of 10mL, using galvanostatic method, current strength 10nA, time 50s.
On the basis of previous step, seaweed acid gel (Al)/multi-walled carbon nanotube (CNT) plating that electroplate liquid is 10mL is replaced
Liquid, using constant voltage method, voltage 3V, time 2s carry out the electro-deposition of seaweed acid gel and multi-walled carbon nanotube mixing material
On the basis of previous step, conducting polymer (CP) electroplate liquid that electroplate liquid is 10mL is replaced, galvanostatic method, electric current is strong
10nA, time 200s are spent, electropolymerization of the conducting polymer (CP) in gel is carried out, is obtained described based on seaweed acid gel
(Al), the nerve electrode of multi-walled carbon nanotube (CNT), conducting polymer (CP).
Above-described embodiment, only presently preferred embodiments of the present invention, is not used for limiting the scope of the present invention, therefore all with this
The equivalence changes that content is done described in invention claim should all be included within scope of the invention as claimed.
Claims (10)
1. a kind of nerve electrode and preparation method thereof, which is characterized in that including basal electrode, the basal electrode surface is equipped with sea
Alginic acid gel, multi-walled carbon nanotube and conductive polymer nanometer composite material.
2. a kind of nerve electrode according to claim 1 and preparation method thereof, which is characterized in that the preparation method packet
It includes：
(1), using galvanostatic method in one layer of conducting polymer of basal electrode surface electro-deposition；
(2) solution is mixed acquisition electricity by the solution for preparing conductive polymer coated many walls nanotube with alginic acid hydrogel
Plating solution, by electroplate liquid electro-deposition alginic acid hydrogel/many walls nanotube/conducting polymer composite material on the electrode of (1)；
(3), electropolymerization conducting polymer on the basis of (2) forms a kind of nerve electrode of Signa Gel percolating network modification.
3. a kind of nerve electrode according to claim 1 or 2 and preparation method thereof, which is characterized in that the multi wall carbon is received
Mitron is the multi-walled carbon nanotube of carboxyl modified, 0.5-2 micron of length, 10-20 nanometers of diameter.
4. a kind of nerve electrode according to claim 1 or 2 and preparation method thereof, which is characterized in that the conducting polymer
Object monomer is ethene dioxythiophene, is p-methyl benzenesulfonic acid to ion.
5. a kind of nerve electrode according to claim 1 or 2 and preparation method thereof, which is characterized in that the conducting polymer
Object solution is polyethylene dioxythiophene or p-methyl benzenesulfonic acid.
6. a kind of nerve electrode according to claim 1 and preparation method thereof, which is characterized in that the basal electrode is band
The nichrome microfilament of insulating layer, about 30 microns of metal end face diameter.
7. a kind of nerve electrode according to claim 2 and preparation method thereof, which is characterized in that the galvanostatic method electrolysis
EDOT concentration 0.1wt%, PSS concentration 0.2wt%, electric current 10nA, time 50s in liquid.
8. a kind of nerve electrode according to claim 2 and preparation method thereof, which is characterized in that the constant voltage method electrolysis
Al concentration 1wt%, CNT concentration 3mg/mL, voltage 3V, time 2s in liquid.
9. a kind of nerve electrode according to claim 2 and preparation method thereof, which is characterized in that the electropolymerization method electricity
Solve EDOT concentration 0.1wt%, PSS concentration 0.2wt%, electric current 10nA, time 200s in liquid.
10. a kind of nerve electrode according to claim 2 and preparation method thereof, which is characterized in that the electrochemical method,
It is all made of three-electrode system, platinum plate electrode is used as to electrode, and Ag or AgCl are as reference electrode.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693480A (en) * | 2019-10-11 | 2020-01-17 | 哈尔滨工业大学 | Implantable neural electrode based on metal-MOF (Metal-organic framework) micro-morphology features and preparation method thereof |
| CN112587140A (en) * | 2020-12-09 | 2021-04-02 | 清华大学深圳国际研究生院 | Self-attaching bionic octopus sucking disc micro-nano structure dry electrode |
| CN115078487A (en) * | 2022-05-18 | 2022-09-20 | 厦门大学 | In-vitro myocardial flexible microelectrode array based on liquid metal and preparation method thereof |
| CN115813399A (en) * | 2022-12-08 | 2023-03-21 | 天津大学 | Nano material modified nerve electrode and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693480A (en) * | 2019-10-11 | 2020-01-17 | 哈尔滨工业大学 | Implantable neural electrode based on metal-MOF (Metal-organic framework) micro-morphology features and preparation method thereof |
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| CN112587140A (en) * | 2020-12-09 | 2021-04-02 | 清华大学深圳国际研究生院 | Self-attaching bionic octopus sucking disc micro-nano structure dry electrode |
| CN115078487A (en) * | 2022-05-18 | 2022-09-20 | 厦门大学 | In-vitro myocardial flexible microelectrode array based on liquid metal and preparation method thereof |
| CN115078487B (en) * | 2022-05-18 | 2024-04-19 | 厦门大学 | Liquid metal-based in-vitro myocardial flexible microelectrode array and preparation method thereof |
| CN115813399A (en) * | 2022-12-08 | 2023-03-21 | 天津大学 | Nano material modified nerve electrode and preparation method thereof |
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Application publication date: 20180928 |