CN108577820A - A kind of quick early warning system of real-time blood pressure and its method - Google Patents

A kind of quick early warning system of real-time blood pressure and its method Download PDF

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CN108577820A
CN108577820A CN201810249730.3A CN201810249730A CN108577820A CN 108577820 A CN108577820 A CN 108577820A CN 201810249730 A CN201810249730 A CN 201810249730A CN 108577820 A CN108577820 A CN 108577820A
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blood pressure
time
pressure
pwa
signal
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何史林
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02141Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/02233Occluders specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346Analysis of electrocardiograms
    • A61B5/349Detecting specific parameters of the electrocardiograph cycle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/725Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/7405Details of notification to user or communication with user or patient ; user input means using sound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
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  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

The invention discloses a kind of real-time quick early warning systems of blood pressure,Including ecg signal acquiring module,Photoelectric sensor,Processor,Buzzer,Air pump,Cuff air bag and pressure sensor,The ecg signal acquiring module and photoelectric sensor are connect with the processor signal,The buzzer is connect with the processor signal,The air pump is connect with the processor signal,The air pump controls the cuff air bag inflation/deflation,The cuff air bag is set on the arm of human body,The pressure sensor is used to monitor the blood pressure on the arm at the cuff air bag,The pressure sensor is also connect with the processor signal,This system can be noninvasive,In real time,Accurately,The effective change dramatically for monitoring patient's blood pressure,The pressure value of its variation of accurate feedback,And it is issued warning signal in time to its guardian,Patient attending physician is enable to respond the variation of its physiological parameter information at the first time,Make counte-rplan in time,Improve patient's survival rate.

Description

A kind of quick early warning system of real-time blood pressure and its method
Technical field
The present invention relates to blood pressure early warning system and its method, more particularly to the quick early warning system of a kind of real-time blood pressure and its side Method.
Background technology
Blood pressure is one important physiological parameter of human body, can reflect the function status of human heart and blood vessel.Human body Blood pressure refers to that endovascular blood, to lateral pressure caused by unit area vascular wall, is ventricular ejection and periphery in flowing The coefficient result of resistance.Blood pressure is divided into angiosthenia, capillary pressure and vein pressure.Usually said blood pressure refers to artery Pressure, it be not only reaction human circulation function important physiological parameter, and clinically diagnose the illness, observe therapeutic effect, into The important evidence of row Index for diagnosis.In the application fields such as emergency treatment and ICU, blood pressure jumpy is that great change occurs for a variety of diseases The important indication changed.Therefore, how rapid examination to patient's pressure value variation, and accurately measure its variation as a result, It timely feedbacks to its attending physician end, seems of crucial importance for patient's survival rate to improving.
It is typically using invasive for the existing timely method for finding patient's blood pressure of the real-time monitoring of critically ill patient Monitoring of blood pressure mode carries out the continuous monitoring of blood pressure;Which is by opening patient vessel, and implantation Miniature Sensor is real-time The pressure value of patient is acquired, operation difficulty is relatively high, and considerable distress is caused to patient, and open blood vessel sensor Implantation easily causes infection, is extremely unfavorable for prolonged monitoring of blood pressure.
In recent years, the measurement method for blood pressure being extrapolated based on pulse wave translation time PWTT algorithms is increasingly becoming major scholar The great direction of research.PWTT refers to that pulse wave is transmitted to peripheral arterial the time it takes from aorta, has with blood pressure Direct relationship, but we can not directly obtain PWTT, can only utilize the ecg wave form figure ECG and periphery pulse of heartbeat each time Wave oscillogram PPG comes secondhand;It is that ECG is obtained by synchronous acquisition electrocardiosignal and pulse wave signal under normal conditions And PPG, the time that the wave crest of R wave of electrocardiosignal reaches used in the characteristic point of pulse wave is PWTT.But this time in fact It is not PWTT truly, but it is that blood is pumped to the preaortic stage to contain pre-ejection PEP, PEP.Greatly PEP is varied less in most cases, can be neglected, but there are special circumstances;For example, some suffer from angiocardiopathy Old man, the PWTT measured is very big, there is a high likelihood that being due to existing PEP;And the research of P.A.Payne et al. This above-mentioned problem is also demonstrated, due to reason existing for PEP, the blood pressure detected based on PWTT algorithms is the result is that unreliable 's.
And the variation of PWA values is utilized to assess blood pressure trend, since PWA and PWTT (Pulse transit time) is at equal proportion Relationship, therefore PWTT is consistent with PWA variation tendencies.When blood pump is entered aorta by heart, a pressure wave can be generated simultaneously, this A pressure wave can downwards transmit before the blood pumped out along artery;Pulse wave conduction speed PWV is by the tight of arterial blood tube wall Zhang Chengdu is determined.When blood pressure increases, artery is gone short of, and pulse wave transmission becomes faster;When blood pressure reduces, arterial wall becomes pine It relaxes, pulse wave transmits slack-off.Therefore the potential variation of blood pressure is can be reacted by the variation of PWV.And the value of PWV can be according to public affairs Formula PWV=L/PWTT be calculated (wherein, L be ECG signal sampling point between pulse wave signal test point at a distance from).Same With one testee, PWV and the inversely proportional relationships of PWTT, therefore when blood pressure increases, PWTT durations measured by same position will become It is short.By the principle, therefore detect the variation of PWTT durations to assess patients' blood's variation, the variation for further relating to PWA values is can be with Express patients' blood's variation.
Invention content
For the above-mentioned prior art, be to provide one kind can be noninvasive, real-time, accurate for the technical problem to be solved in the present invention Really, the change dramatically of patient's blood pressure, the pressure value of its variation of accurate feedback are effectively monitored, and is sent out in time to its guardian A kind of quick early warning system of real-time blood pressure and its method of pre-warning signal.
The present invention provides a kind of real-time quick early warning system of blood pressure, including ecg signal acquiring module, photoelectric sensor, place Manage device, buzzer, air pump, cuff air bag and pressure sensor, the ecg signal acquiring module and photoelectric sensor are and institute Processor signal connection is stated, the buzzer is connect with the processor signal, and the air pump is connect with the processor signal, The air pump controls the cuff air bag inflation/deflation, and the cuff air bag is set on the arm of human body, and the pressure sensor is used Blood pressure on the arm monitored at the cuff air bag, the pressure sensor are also connect with the processor signal.
A kind of quick method for early warning of real-time blood pressure, includes the following steps:
S1:If the time used in R wave of electrocardiosignal wave crest point to pulse wave wave crest point is peak time difference PWA, and is set The normal value section of peak time difference PWA;
S2:Using ecg signal acquiring module acquire subject electrocardiosignal, using photoelectric sensor acquisition acquisition by The pulse wave signal of examination person, to obtain electro-cardiologic signal waveforms figure ECG and pulse waveform figure PPG, to the R wave wave crest points of ECG Position mark, and the value of the PWA by calculating acquisition mark position are carried out with the wave crest point of PPG;
S3:By the difference of current PWA (N) measured values and the last time PWA (N-1) measured value, and according to the PWA (N) whether the difference between measured value and PWA (N-1) measured value belongs to normal value section, so judge patient blood pressure whether Change dramatically occurs;
S4:If change dramatically occurs for blood pressure, gas is filled with to the cuff air bag by the air pump, and by described The arm vascular flow of the pressure blocking subject of cuff air bag is become using the fluctuation of the pressure sensor monitoring blood pressure pressure Change, and the fluctuating change data transmission of blood pressure pressure is calculated to processor and obtains the systolic pressure of blood pressure and diastole at this time Pressure;
S5:Buzzer is set to send out alarm signal by the processor.
Further, when carrying out the measurement of PWA, current PWA measured values and the last time PWA measured values are repeatedly calculated Difference.
Further, collected ECG and PPG is smoothed using smothing filtering method.
The beneficial effects of the present invention are:
A kind of real-time quick early warning system of blood pressure provided by the invention, by including ecg signal acquiring module and photoelectric transfer Sensor acquires the electrocardiosignal and pulse wave signal of subject in real time, to which electrocardiosignal and pulse wave signal are sent to processing It is handled in device, and the signal of the processor is sent to air pump according to the actual conditions of subject so that air pump is to institute The detection that cuff air bag is inflated and carries out blood pressure by pressure sensor is stated, it is finally that the pressure sensor is obtained Whether data are sent to the processor, to be in just by the blood pressure of the data judging subject stored by the processor Reason condition, and then the progress for controlling by processor buzzer is alarmed accordingly, monitoring that can be noninvasive, real-time, accurate and effective To the change dramatically of patient's blood pressure, the pressure value of its variation of accurate feedback, and issued warning signal in time to its guardian so that Patient attending physician can respond the variation of its physiological parameter information at the first time, make counte-rplan in time, improve patient's life Deposit rate.
Description of the drawings
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only the preferred embodiment of the present invention, for For those of ordinary skill in the art, without having to pay creative labor, it can also be obtained according to these attached drawings His attached drawing.
Fig. 1 is a kind of structure chart of the real-time quick early warning system of blood pressure of the present invention;
Fig. 2 is a kind of oscillogram of the electrocardiosignal and pulse wave signal of the real-time quick method for early warning of blood pressure of the present invention;
Fig. 3 is that generated pressure wave shows when a kind of blood pump of the real-time quick method for early warning of blood pressure of the present invention enters aorta It is intended to;
Fig. 4 is to illustrate with PWA time trends a kind of present invention PWTT times of the real-time quick method for early warning of blood pressure Figure;
Fig. 5 is a kind of logical schematic of the real-time quick method for early warning of blood pressure of the present invention.
In figure, 1 is ecg signal acquiring module, and 2 be photoelectric sensor, and 3 be processor, and 4 be buzzer, and 5 be air pump, 6 It is pressure sensor for cuff air bag, 7.
Specific implementation mode
In order to be best understood from the technology of the present invention content, be provided below specific embodiment, and in conjunction with attached drawing to the present invention do into The explanation of one step.
Referring to Fig. 1, a kind of real-time quick early warning system of blood pressure, including ecg signal acquiring module 1, photoelectric sensor 2, place Manage device 3, buzzer 4, air pump 5, cuff air bag 6 and pressure sensor 7, the ecg signal acquiring module 1 and photoelectric sensor 2 It is connect with 3 signal of the processor, the buzzer 4 is connect with 3 signal of the processor, the air pump 5 and the processing 3 signal of device connects, and the air pump 5 controls 6 inflation/deflation of cuff air bag, and the cuff air bag 6 is set on the arm of human body, institute Pressure sensor 7 is stated for monitoring the blood pressure on arm at the cuff air bag 6, the pressure sensor 7 also with institute The connection of 3 signal of processor is stated, by the electrocardio for acquiring subject in real time including ecg signal acquiring module 1 and photoelectric sensor 2 Signal and pulse wave signal are handled so that electrocardiosignal and pulse wave signal to be sent in processor 3, and by the place The signal of reason device 3 is sent to air pump 5 according to the actual conditions of subject so that air pump 5 is inflated simultaneously the cuff air bag 6 7 obtained data of the pressure sensor are finally sent to the processing by the detection that blood pressure is carried out by pressure sensor 7 Device 3 to whether be in normal condition by the blood pressure of the data judging subject stored by the processor 3, and then passes through The progress that processor 3 controls buzzer 4 is alarmed accordingly, can be noninvasive, real-time, accurate and effective monitor patient's blood pressure Change dramatically, the pressure value of its variation of accurate feedback, and issued warning signal in time to its guardian so that patient attending physician Counte-rplan are made in the variation that its physiological parameter information can be responded at the first time in time, improve patient's survival rate.
Referring to Fig. 2, left side is the oscillogram of electrocardiosignal and pulse wave signal, is made with electro-cardiologic signal waveforms in clinical diagnosis For the basis for estimation of cardiac mechanical movement, the peak positions the R closest cardiac ejection time wherein in QRS wave;Referring to Fig. 3, take care Dirty to generate a pressure wave simultaneously when blood pump is entered aorta, this pressure wave can be before the blood pumped out along dynamic Arteries and veins transmits downwards;Referring to Fig. 4, coring electric signal pulse wave signal graphic correlation synchronous with finger tip, from the peaks ECG signal R to PPG The position of signal trough is pulse wave translation time PWTT, is peak time from the peaks ECG signal R to the time of PPG signal wave crests Poor PWA, then the PWTT times are consistent with PWA time trends;Referring to Fig. 5, a kind of quick pre- police of real-time blood pressure of the invention Method includes the following steps:
S1:If the time used in R wave of electrocardiosignal wave crest point to pulse wave wave crest point is peak time difference PWA, and is set The normal value section of peak time difference PWA;
S2:The electrocardiosignal that subject is acquired using ecg signal acquiring module 1 is acquired using photoelectric sensor 2 The pulse wave signal of subject, to obtain electro-cardiologic signal waveforms figure ECG and pulse waveform figure PPG, to the R wave wave crests of ECG The wave crest point of point and PPG carry out position mark, and the value of the PWA by calculating acquisition mark position;
S3:By the difference of current PWA (N) measured values and the last time PWA (N-1) measured value, and according to the PWA (N) whether the difference between measured value and PWA (N-1) measured value belongs to normal value section, so judge patient blood pressure whether Change dramatically occurs;
S4:If change dramatically occurs for blood pressure, gas is filled with to the cuff air bag 6 by the air pump 5, and pass through institute The arm vascular flow for stating the pressure blocking subject of cuff air bag 6 monitors the wave of blood pressure pressure using the pressure sensor 7 Dynamic variation, and the fluctuating change data transmission of blood pressure pressure is calculated to processor 3 and obtains the systolic pressure of blood pressure at this time With diastolic pressure;
S5:Buzzer 4 is set to send out alarm signal by the processor 3.
Specifically, when carrying out the measurement of PWA, the difference of current PWA measured values and the last time PWA measured values is repeatedly calculated Value realizes the standard of measurement data and result by repeatedly calculating the difference of current PWA measured values and the last time PWA measured values True property avoids the issuable error of single measurement institute, reduces the wrong report of measurement result, avoid and increase the follow-up work of medical staff Working strength when making.
Specifically, being smoothed using smothing filtering method to collected ECG and PPG, electrocardiosignal wave is avoided Shape figure ECG and pulse waveform figure PPG is excessively coarse and causes the wave crest point of the R waves wave crest point of ECG and PPG not clear enough, keeps away The selection mistake for having exempted from R waves wave crest point and the wave crest point of PPG, so as to avoid subsequent calculating mistake.
When starting patient care work, its PWA normal values area is set according to the current illness of patient and blood pressure state Between, unit is s (second);The electrocardiosignal and pulse wave signal for then acquiring testee in real time, to obtain electro-cardiologic signal waveforms figure ECG and pulse waveform figure PPG;Smooth processing is carried out using smothing filtering method to collected ECG and PPG, to the R of ECG The wave crest point of wave wave crest point and PPG carry out position mark, and the value for obtaining PWA is calculated using algorithm;And then judge current measure Whether the difference of value PWA (N) and the last time measured value PWA (N-1) is in normal value section:
When the difference of PWA (N)-PWA (N-1) is in normal value section, show that subject's blood pressure is normal, display is nearest Blood pressure measurement, assessment terminate;
When the difference of PWA (N)-PWA (N-1) is not or not normal value section, predict that the blood pressure of subject is changed, it is right The point is marked, and the measurement of blood pressure is carried out by the cooperation of air pump 5, cuff air bag 6 and pressure sensor 7, obtains current Blood pressure actual value, if pressure value makes buzzer 4 send out alarm signal not in normal range (NR), by processor 3 notifies guardian, Enable patient attending physician to respond the variation of its physiological parameter information at the first time, make counte-rplan in time, improves disease People living rate, and show current pressure value;If institute's measuring blood pressure shows current pressure value in normal range (NR).
Normotensive value range, 90mmHg<Systolic pressure<140mmHg、60mmHg<Diastolic pressure<90mmHg.
Noninvasive, real-time, the accurate and effective change dramatically for monitoring patient's blood pressure can be realized by this method, accurately The pressure value of testee's variation is fed back, and accuracy rate and the more traditional detection method of the efficiency of detection are obtained and significantly carried It rises, realizes the progress of blood pressure detecting method.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.

Claims (4)

1. a kind of quick early warning system of real-time blood pressure, which is characterized in that including ecg signal acquiring module, photoelectric sensor, place Manage device, buzzer, air pump, cuff air bag and pressure sensor, the ecg signal acquiring module and photoelectric sensor are and institute Processor signal connection is stated, the buzzer is connect with the processor signal, and the air pump is connect with the processor signal, The air pump controls the cuff air bag inflation/deflation, and the cuff air bag is set on the arm of human body, and the pressure sensor is used Blood pressure on the arm monitored at the cuff air bag, the pressure sensor are also connect with the processor signal.
2. a kind of method for early warning of real-time quick early warning system of blood pressure according to claim 1, which is characterized in that including with Lower step:
S1:If the time used in R wave of electrocardiosignal wave crest point to pulse wave wave crest point is peak time difference PWA, and sets wave crest The normal value section of time difference PWA;
S2:The electrocardiosignal that subject is acquired using the ecg signal acquiring module, is adopted using the photoelectric sensor The pulse wave signal for collecting subject, to obtain electro-cardiologic signal waveforms figure ECG and pulse waveform figure PPG, to the R wave waves of ECG The wave crest point of peak dot and PPG carry out position mark, and the value of the PWA by calculating acquisition mark position;
S3:It is surveyed by the difference of current PWA (N) measured values and the last time PWA (N-1) measured value, and according to the PWA (N) Whether the difference between magnitude and PWA (N-1) measured value belongs to normal value section, and then judges whether the blood pressure of patient occurs urgency Drastic change;
S4:If change dramatically occurs for blood pressure, gas is filled with to the cuff air bag by the air pump, and pass through the cuff The arm vascular flow of the pressure blocking subject of air bag, using the fluctuating change of the pressure sensor monitoring blood pressure pressure, And the fluctuating change data transmission of blood pressure pressure is calculated to processor and obtains the systolic pressure and diastolic pressure of blood pressure at this time;
S5:Buzzer is set to send out alarm signal by the processor.
3. a kind of method for early warning of real-time quick early warning system of blood pressure according to claim 2, which is characterized in that carrying out When the measurement of PWA, the difference of current PWA measured values and the last time PWA measured values is repeatedly calculated.
4. a kind of method for early warning of real-time quick early warning system of blood pressure according to claim 2, which is characterized in that acquisition To ECG and PPG be smoothed using smothing filtering method.
CN201810249730.3A 2018-03-26 2018-03-26 A kind of quick early warning system of real-time blood pressure and its method Pending CN108577820A (en)

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CN101327121A (en) * 2007-06-22 2008-12-24 香港中文大学 Physiological parameter measurement mechanism
CN102123659A (en) * 2008-08-19 2011-07-13 皇家飞利浦电子股份有限公司 Monitoring the blood pressure of a patient
US20100298650A1 (en) * 2009-05-20 2010-11-25 Triage Wireless, Inc. Vital sign monitoring system featuring 3 accelerometers
CN102178518A (en) * 2011-05-31 2011-09-14 北京新兴阳升科技有限公司 Individualized correction method and device used for continuous measurement and estimation of arterial blood pressure by pulse wave
CN202335858U (en) * 2011-11-03 2012-07-18 吴锋 Beat-to-beat blood pressure detection device
CN103371808A (en) * 2012-04-27 2013-10-30 通用电气公司 Method for handling pressure changes in invasive blood pressure monitoring and apparatus for blood pressure monitoring
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Application publication date: 20180928