CN108562663A - A kind of analytical equipment for drug line detection - Google Patents
A kind of analytical equipment for drug line detection Download PDFInfo
- Publication number
- CN108562663A CN108562663A CN201810316835.6A CN201810316835A CN108562663A CN 108562663 A CN108562663 A CN 108562663A CN 201810316835 A CN201810316835 A CN 201810316835A CN 108562663 A CN108562663 A CN 108562663A
- Authority
- CN
- China
- Prior art keywords
- gas chromatograph
- drug
- detector
- analytical equipment
- line detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/64—Electrical detectors
- G01N30/68—Flame ionisation detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/025—Gas chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to a kind of analytical equipments for drug line detection, including drug pipes, Raman spectrometer, temperature compensator, gas chromatograph and mass spectrograph, the mass spectrograph connects to form the first detection module with gas chromatograph, the mass spectrograph is connected to after the gas chromatograph, the temperature compensator connects to form the second detection module with the Raman spectrometer, the Raman spectrometer is connected to after the temperature compensator, described first, two detection modules in parallel are connected in the drug pipes, solenoid valve and mateiral pump are installed in the drug pipes, the gas chromatograph has at least one detector, and the detector of gas chromatograph includes thermal conductivity detector (TCD), this is used for the analytical equipment of drug line detection, it can detect in real time, improve detection efficiency, ensure detection accuracy.
Description
Technical field
The present invention relates to pharmaceutical analysis apparatus field more particularly to a kind of analytical equipments for drug line detection.
Background technology
Mass spectrography can carry out effective qualitative analysis, but just seem helpless to the analysis of complex organic compound；
And chromatography is that one kind efficiently separating analysis method to organic compound, is divided particularly suitable for carrying out the quantitative of organic compound
Analysis, but qualitative analysis is then relatively difficult.However efficient, quantitative analysis recited above, it is also only based on and is probably recognizing
It is carried out on the basis of substance that may be present in sample.And in some environmental samplings, the cost in sample is very multiple
Hydridization, in addition to can predict it is that may be present have substance other than, there is also many unknown ingredients, and present analysis personnel are only
The data shown by gas chromatograph-mass spectrometer, for unforeseeable ingredient be a lack of capture property and it is analytical.
Drug batch mixing uniformity quality and medicine material concentration directly influence the drug effect of finished medicines, at this stage, drug
The general way of detection be to be shut down at the time of thinking that batch mixing is uniform, then in mixing tank the different parts of material sample into
Row laboratory assay is analyzed, but due to the poor in timeliness of the way, it is time-consuming, laborious, reduce production efficiency, last batch mixing
The uniformity can not be completely secured.
Invention content
In order to solve the above technical problems, the object of the present invention is to provide a kind of analytical equipment for drug line detection,
It can detect in real time, improve detection efficiency, ensure detection accuracy.
A kind of analytical equipment for drug line detection of the present invention, including drug pipes, Raman spectrometer, temperature are mended
Device, gas chromatograph and mass spectrograph are repaid, the mass spectrograph connects to form the first detection module, the mass spectrograph with gas chromatograph
It being connected to after the gas chromatograph, the temperature compensator connects to form the second detection module with the Raman spectrometer,
The Raman spectrometer is connected to after the temperature compensator, and the first and second detection modules in parallel is connected to the drug
On pipeline, solenoid valve and mateiral pump being installed in the drug pipes, the gas chromatograph has at least one detector, and
The detector of gas chromatograph includes thermal conductivity detector (TCD).
Further, the detector of the gas chromatograph further includes flame ionisation detector, the flame ionization detection
Device is connected to after thermal conductivity detector (TCD).
Further, the temperature compensator includes high-temperature compensator, low temp compensating device and temperature inductor, the high temperature
Compensator and low temp compensating device are connected in the rear of the temperature inductor in parallel.
Further, the mass spectrograph is quadrupole mass spectrometer.
Further, the mass spectrograph is ion trap mass spectrometer.
Further, the mass spectrograph is time of-flight mass spectrometer.
Further, the mass spectrograph is magnetic mass spectrometer.
According to the above aspect of the present invention, the present invention has at least the following advantages：In thermal conductivity detector (TCD) in the gas chromatograph of the present invention
Detector of the connection flame ionisation detector as thermal conductivity detector (TCD) later, improves the capturing ability of gas chromatograph, and
The detection of the drug batch mixing uniformity may be implemented in the characteristic spectrum data that drug ingedient to be detected is acquired by raman laser technology,
It need not model, quickly, efficiently.It is combined by Raman spectrum data data and spectrogram, testing result is more intuitive, to mixing process
In batch mixing uniformity situation it is very clear, in real time grasp, improve the efficiency and accuracy rate of batch mixing.Accuracy rate be up to 95% with
On, accuracy of detection can be realized within 0.01.Capture and data indication range and the ability for improving equipment, are capable of providing to analysis
Personnel's sample data as much as possible makes data more diversification, to reduce the analysis difficulty of analysis personnel.
The equipment can carry out real time on-line monitoring in medicine production process, and some drugs are acquired using LR laser raman technology
The characteristic spectrum data of raw material in the reaction vessel realize that concentration situation of change is detected, efficiently, quickly, it is accurate, simultaneously
The detection of a variety of medicine materials can be achieved, medicine material can be gas, liquid, solid state, while be equipped with temperature-compensating machine
System eliminates influence of the temperature change to testing result.
Above description is only the general introduction of technical solution of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, below with presently preferred embodiments of the present invention and after coordinating attached drawing to be described in detail such as.
Description of the drawings
Fig. 1 is the principle of the present invention schematic diagram.
Specific implementation mode
With reference to the accompanying drawings and examples, the specific implementation mode of the present invention is described in further detail.Implement below
Example is not limited to the scope of the present invention for illustrating the present invention.
Embodiment：A kind of analytical equipment for drug line detection, including drug pipes 1, Raman spectrometer 2, temperature
Compensator 3, gas chromatograph 4 and mass spectrograph 5, the mass spectrograph connects to form the first detection module with gas chromatograph, described
Mass spectrograph is connected to after the gas chromatograph, and the temperature compensator connects to form the second detection with the Raman spectrometer
Module, the Raman spectrometer are connected to after the temperature compensator, and the first and second detection modules in parallel is connected to described
In drug pipes, solenoid valve 6 and mateiral pump 7 are installed in the drug pipes, the gas chromatograph has at least one inspection
Device is surveyed, and the detector of gas chromatograph includes thermal conductivity detector (TCD) 11.
The detector of the gas chromatograph further includes flame ionisation detector 12, and the flame ionisation detector is connected to
After thermal conductivity detector (TCD).
The temperature compensator includes high-temperature compensator 13, low temp compensating device 14 and temperature inductor 15, the high temperature compensation
It repays device and low temp compensating device is connected in the rear of the temperature inductor in parallel.
The mass spectrograph is quadrupole mass spectrometer.
The mass spectrograph is ion trap mass spectrometer.
The mass spectrograph is time of-flight mass spectrometer.
The mass spectrograph is magnetic mass spectrometer.
The equipment is used as Thermal Conductivity by connecting flame ionisation detector in gas chromatograph after thermal conductivity detector (TCD)
The detector of device improves the capturing ability of gas chromatograph, and acquires drug ingedient to be detected by raman laser technology
Characteristic spectrum data, the detection of the drug batch mixing uniformity may be implemented, without modeling, quickly, efficiently.Pass through Raman spectrum data
Data and spectrogram combine, and testing result is more intuitive, very clear to the batch mixing uniformity situation in mixing process, slap in real time
It holds, improves the efficiency and accuracy rate of batch mixing.Accuracy rate is up to 95% or more, and accuracy of detection can be realized within 0.01.It improves
The capture of equipment and data indication range and ability, are capable of providing and give analysis personnel sample data as much as possible, make data more
Diversification, to reduce the analysis difficulty of analysis personnel.
The equipment can carry out real time on-line monitoring in medicine production process, and some drugs are acquired using LR laser raman technology
The characteristic spectrum data of raw material in the reaction vessel realize that concentration situation of change is detected, efficiently, quickly, it is accurate, simultaneously
The detection of a variety of medicine materials can be achieved, medicine material can be gas, liquid, solid state, while be equipped with temperature-compensating machine
System eliminates influence of the temperature change to testing result.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of analytical equipment for drug line detection, it is characterised in that：Including drug pipes, Raman spectrometer, temperature
Compensator, gas chromatograph and mass spectrograph, the mass spectrograph connect to form the first detection module, the mass spectrum with gas chromatograph
Instrument is connected to after the gas chromatograph, and the temperature compensator connects to form the second detection mould with the Raman spectrometer
Group, the Raman spectrometer are connected to after the temperature compensator, and the first and second detection modules in parallel is connected to the medicine
In conduit, solenoid valve and mateiral pump being installed in the drug pipes, the gas chromatograph has at least one detector,
And the detector of gas chromatograph includes thermal conductivity detector (TCD).
2. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The gas phase color
The detector of spectrometer further includes flame ionisation detector, and the flame ionisation detector is connected to after thermal conductivity detector (TCD).
3. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The temperature is mended
It includes high-temperature compensator, low temp compensating device and temperature inductor to repay device, and the high-temperature compensator and low temp compensating device are connected in parallel
At the rear of the temperature inductor.
4. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The mass spectrograph
For quadrupole mass spectrometer.
5. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The mass spectrograph
For ion trap mass spectrometer.
6. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The mass spectrograph
For time of-flight mass spectrometer.
7. a kind of analytical equipment for drug line detection according to claim 1, it is characterised in that：The mass spectrograph
For magnetic mass spectrometer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316835.6A CN108562663A (en) | 2018-04-10 | 2018-04-10 | A kind of analytical equipment for drug line detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316835.6A CN108562663A (en) | 2018-04-10 | 2018-04-10 | A kind of analytical equipment for drug line detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108562663A true CN108562663A (en) | 2018-09-21 |
Family
ID=63534671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810316835.6A Withdrawn CN108562663A (en) | 2018-04-10 | 2018-04-10 | A kind of analytical equipment for drug line detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108562663A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023152412A1 (en) * | 2022-02-14 | 2023-08-17 | Universidad De Valladolid | System and method for preparing and distributing samples for combined analysis by means of raman spectroscopy and liquid chromatography |
-
2018
- 2018-04-10 CN CN201810316835.6A patent/CN108562663A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023152412A1 (en) * | 2022-02-14 | 2023-08-17 | Universidad De Valladolid | System and method for preparing and distributing samples for combined analysis by means of raman spectroscopy and liquid chromatography |
| ES2948214A1 (en) * | 2022-02-14 | 2023-09-06 | Univ Valladolid | SYSTEM AND PROCESS FOR PREPARATION AND DISTRIBUTION OF SAMPLES FOR COMBINED ANALYSIS USING RAMAN SPECTROSCOPY AND LIQUID CHROMATOGRAPHY (Machine-translation by Google Translate, not legally binding) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lian et al. | Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS) | |
| JP2017509901A5 (en) | ||
| CN104297406B (en) | A kind of wide spectrum identifies the method for beta-receptor stimulant medicine | |
| CN105223264A (en) | Mark method, device and application in a kind of simulation of mass spectrum quantitative test | |
| CN105353056A (en) | Volatile organic compound online monitoring system | |
| CN108896670A (en) | PPCPs pollutant rapid screening detection method in Drinking Water | |
| CN204389458U (en) | A kind of gas chromatographicanalyzer for analyzing sulfur hexafluoride decomposition product | |
| CN205538861U (en) | Volatile organic compounds on -line monitoring system | |
| EP3470833A1 (en) | Specific substance monitoring system using mass spectrometer | |
| CN103645272B (en) | Method for detecting high-boiling-point substances in industrial products | |
| CN105004832A (en) | Four-spectrometer combined analytical instrument suitable for complex chemical samples | |
| DE102010039275B4 (en) | Method and apparatus for the online determination of the isotopic ratio of chlorine, bromine or sulfur in an organic sample | |
| Gong et al. | An online method combining a thermal conversion elemental analyzer with isotope ratio mass spectrometry for the determination of hydrogen isotope composition and water concentration in geological samples | |
| Hajialigol et al. | Thermal solid sample introduction–fast gas chromatography–low flow ion mobility spectrometry as a field screening detection system | |
| US20060210442A1 (en) | Apparatus and method for analyzing nitropolycyclic aromatic hydrocarbon contained in diesel particulate | |
| CN108562663A (en) | A kind of analytical equipment for drug line detection | |
| CN106596773A (en) | Method for simultaneous and rapidly screening and testing multiple veterinary drug residues in animal-derived food | |
| US8686353B2 (en) | Apparatus system and method for mass analysis of a sample | |
| CN105784900A (en) | LC-Q-TOF/MS detection technique for 544 pesticide residues in solanaceous fruit vegetables | |
| CN208155947U (en) | A kind of analytical equipment for drug line detection | |
| CN105334282B (en) | Co-detecting method for environmental estrogens in surface water body | |
| CN204964469U (en) | Four combined analytical instruments suitable for complicated chemical industry sample | |
| CN114414708B (en) | Method for detecting tetraethylene glycol dimethyl ether | |
| CN104390831A (en) | Method and device for preparing standard methacrylic acid gas sample | |
| JP2020527239A (en) | Equipment and methods for partial conversion of fluid samples containing multiple components, and methods for online determination and analysis of these components |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180921 |
|
| WW01 | Invention patent application withdrawn after publication |