CN108558770B - Preparation method of diamino nitrogen-containing aromatic heterocyclic compound - Google Patents
Preparation method of diamino nitrogen-containing aromatic heterocyclic compound Download PDFInfo
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract
The invention relates to the technical field of compound synthesis, in particular to a preparation method of a diamino nitrogen-containing aromatic heterocyclic compound. In addition, the preparation method provided by the invention has the advantages of simple and environment-friendly route, low cost and mild reaction conditions, and is suitable for large-scale popularization and application. Experimental results show that the diamino nitrogen-containing aromatic heterocyclic compound prepared by the preparation method has the yield of not less than 90 percent, even 96 percent; purity > 99.9%.
Description
Technical Field
The invention relates to the technical field of compound synthesis, in particular to a preparation method of a diamino nitrogen-containing aromatic heterocyclic compound.
Background
The diamino nitrogen-containing aromatic heterocyclic compound is an important aromatic diamine and is widely applied to dye intermediates, indicators for detecting metal ions, epoxy resin curing agents and the like, and meanwhile, the aromatic diamine is an important polymer synthesis monomer and is used for synthesizing polymers such as polyimide, polyamide and the like. Therefore, the research on the synthesis method of the diamino nitrogen-containing aromatic heterocyclic compound attracts extensive attention.
The diamino nitrogen-containing aromatic heterocyclic compound is usually obtained by reducing a nitro nitrogen-containing aromatic heterocyclic compound, and the commonly used reduction method is mainly catalytic reduction. Catalytic hydrogenation is an important method for reducing nitro group to amino group, and usually employs noble metal catalysts such as palladium, platinum, rhodium, etc., which need to be supported on flammable carbon carrier, and uses hydrogen or hydrazine hydrate as reducing agent, and ethers, alcohols, esters or lipids as solvent. However, the yield of the resulting diamino nitrogen-containing heteroaromatic compound was too low. For example, Hasegawa et al (Polymer, 2017, 111: 91-102) reported the synthesis of 2, 6-bis (4-aminophenyl) benzodioxazole by hydrogen reduction of 2, 6-bis (4-nitrophenyl) benzodioxazole under palladium-carbon catalysis in only 48% yield. Xia et al (J.Appl.Polym.Sci., 2013, 129: 145-151) reported the synthesis of 5-amino-2- (aminophenyl) benzimidazole with only 70% yield from the reduction of 5-nitro-2- (nitrophenyl) benzimidazole with hydrazine hydrate catalyzed on palladium on carbon.
Another reduction method is metal reduction using iron, zinc or tin powder, using solid suspensions of these metals, however, the yield is not optimistic.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a method for preparing a diamino nitrogen-containing aromatic heterocyclic compound, wherein the method for preparing the diamino nitrogen-containing aromatic heterocyclic compound has a high yield.
The invention provides a preparation method of a diamino nitrogen-containing aromatic heterocyclic compound, which comprises the following steps:
A) mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution;
O2N-R-NO2 (I)；
wherein R is a group comprising a nitrogen-containing aromatic heterocyclic structure;
B) mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution;
C) mixing the second mixed solution with alkali liquor, and reacting to obtain a diamino nitrogen-containing aromatic heterocyclic compound with a structure shown in a formula (II);
H2N-R-NH2 (Ⅱ)；
wherein R is a group including a nitrogen-containing aromatic heterocyclic structure.
Preferably, the R also comprises a benzene ring structure or a benzene ring structure containing a substituent.
Preferably, the R is a group having one structure selected from a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure; or R is a group comprising one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure in combination with a benzene ring structure; or R is a group comprising one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure in combination with a substituted benzene ring structure.
Preferably, the substituent group comprises one or more of alkyl, aryl, hydroxyl, alkoxy, phenoxy, cyano, amino, amido, ester, acyl, halogen and carboxyl.
Preferably, R is selected from one of formulae (1) to (24):
preferably, the inorganic acid is selected from one of hydrochloric acid, sulfuric acid, phosphoric acid, sulfurous acid, hypophosphorous acid, hydrosulfuric acid, tetrafluoroboric acid and hexafluorophosphoric acid;
the sulfide is selected from one or more of sodium hydrosulfide solid, sodium sulfide solid, sodium disulfide solid, sodium polysulfide solid, ammonium sulfide solid, sodium bisulfite solid, sodium sulfite solid, sodium thiosulfate solid and sodium dithionite solid;
the alkali liquor is selected from one of sodium hydroxide aqueous solution, potassium carbonate aqueous solution, sodium carbonate aqueous solution, ammonia water, triethylamine and triethanolamine.
Preferably, the use amount ratio of the compound with the structure shown in the formula (I) to water is 2-25 g: 100 mL;
the molar ratio of the compound having the structure shown in the formula (I) to the sulfide is 1: 2 to 30.
Preferably, the pH of the first mixed solution is not higher than 2.
Preferably, in the step B), the reaction temperature is 95-105 ℃, and the reaction time is 10-30 h.
Preferably, in the step C), the pH value of the mixed solution is 7-8.
The invention provides a preparation method of a diamino nitrogen-containing aromatic heterocyclic compound, which comprises the following steps:
A) mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution;
O2N-R-NO2 (I)；
wherein R is a group comprising a nitrogen-containing aromatic heterocyclic structure;
B) mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution;
C) mixing the second mixed solution with alkali liquor, and reacting to obtain a diamino nitrogen-containing aromatic heterocyclic compound with a structure shown in a formula (II);
H2N-R-NH2 (Ⅱ)；
wherein R is a group including a nitrogen-containing aromatic heterocyclic structure.
The compound with the structure shown in the formula (I) is mixed with inorganic acid, water-soluble organic matters are obtained after reaction, nitro organic matters can be effectively reduced into amino compounds through reduction of reducing agent sulfide, and then the amino compounds are neutralized through alkali liquor, so that the diamino nitrogen-containing aromatic heterocyclic compound with the structure shown in the formula (II) with high yield and purity is obtained. In addition, the preparation method provided by the invention has the advantages of simple and environment-friendly route, low cost and mild reaction conditions, and is suitable for large-scale popularization and application.
Experimental results show that the diamino nitrogen-containing aromatic heterocyclic compound prepared by the preparation method has the yield of not less than 90 percent, even 96 percent; purity (HPLC) > 99.9%.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A) Mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution;
O2N-R-NO2 (I)；
wherein R is a group comprising a nitrogen-containing aromatic heterocyclic structure;
B) mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution;
C) mixing the second mixed solution with alkali liquor, and reacting to obtain a diamino nitrogen-containing aromatic heterocyclic compound with a structure shown in a formula (II);
H2N-R-NH2 (Ⅱ)；
wherein R is a group including a nitrogen-containing aromatic heterocyclic structure.
In the present invention, the R preferably further includes a benzene ring structure or a substituted benzene ring structure. More preferably, the R includes a group having one structure of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure, and a pyrimidine ring structure; or R is a group comprising one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure in combination with a benzene ring structure; or R is a group comprising one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure in combination with a substituted benzene ring structure.
The substituent preferably comprises one or more of alkyl, aryl, hydroxyl, alkoxy, phenoxy, cyano, amino, amido, ester group, acyl, halogen and carboxyl; more preferably, the compound comprises one or more of alkyl with 1-5 carbon atoms, phenyl, hydroxyl, alkoxy with 1-5 carbon atoms, phenoxy, cyano, amino, acylamino with 1-5 carbon atoms, ester with 1-5 carbon atoms, acyl with 1-5 carbon atoms, halogen and carboxyl.
Most preferably, R is one of formula (1) to formula (24):
in certain embodiments of the invention, the compound having the structure of formula (I) is 2- (4-nitrophenyl) -5-nitrobenzimidazole, 2- (4-nitrophenyl) -5-nitrobenzoxazole, 2 '-bis (4-nitrophenyl) -5,5' -biphenyldiimidazole, 2, 6-bis (4-nitrophenyl) benzobisoxazole, 2- (4-nitrophenyl) -5-nitropyridine, 2, 5-bis (4-nitrophenyl) pyridine, 2-nitro-5- (2-hydroxy-4-nitrophenyl) benzimidazole, 2, 6-bis (2-hydroxy-4-nitrophenyl) benzobisoxazole, 2- (2-hydroxy-4-nitrophenyl) -5-nitropyridine, or 2- (2-hydroxy-4-nitrophenyl) -5- (4-nitrophenyl) pyrimidine.
In the present invention, the inorganic acid is preferably one of hydrochloric acid, sulfuric acid, phosphoric acid, sulfurous acid, hypophosphorous acid, hydrosulfuric acid, tetrafluoroboric acid and hexafluorophosphoric acid.
Mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution. The water is a solvent. The dosage ratio of the compound with the structure shown in the formula (I) to water is preferably 2-25 g: 100 mL. In certain embodiments of the invention, the compound having the structure of formula (I) and water are used in a ratio of 2.84 g: 100mL, 3.22 g: 100mL, 4.76 g: 100mL, 4.02 g: 100mL, 2.45 g: 100mL, 2.46 g: 100mL, 3.21 g: 100mL, 3.00 g: 100mL, 4.34 g: 100mL, 2.61 g: 100mL or 3.38 g: 100 mL. The inorganic acid reacts with the compound with the structure shown in the formula (I), and meanwhile, the inorganic acid is also used for adjusting the pH value of the first mixed solution. The pH of the first mixed solution is preferably not higher than 2. In certain embodiments of the present invention, the pH of the first mixed solution is less than 1.
The temperature of the reaction is preferably room temperature. The reaction time is not particularly limited in the present invention, and the reaction can be stopped when the pH of the obtained first mixed solution meets the requirement.
And after the first mixed solution is obtained, mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution.
The sulfide is a reducing agent and can effectively reduce the nitro organic compound into an amino compound. The sulfide is preferably one or more of sodium hydrosulfide solid, sodium sulfide solid, sodium disulfide solid, sodium polysulfide solid, ammonium sulfide solid, sodium bisulfite solid, sodium sulfite solid, sodium thiosulfate solid and sodium dithionite solid.
The molar ratio of the compound having the structure represented by formula (I) to the sulfide is preferably 1: 2-30; more preferably 1: 4 to 25. In certain embodiments of the invention, the compound having the structure of formula (I) and the sulfide are present in a molar ratio of 1: 5. 1: 6. 1: 20. 1: 10. 1: 7. 1: 12. 1: 8 or 1: 10.
the reaction temperature is preferably 95-105 ℃. In certain embodiments of the invention, the temperature of the reaction is 100 ℃. The reaction time is preferably 10-30 h. In certain embodiments of the invention, the reaction time is 12h, 16h, 28h, 25h, 15h, 20h, 22h, 24h, 21h, or 18 h.
After the reaction, it is preferable to further include cooling. The method for reducing the temperature is not particularly limited, and a method for reducing the temperature known to those skilled in the art can be adopted. The temperature of the temperature reduction is preferably room temperature.
After the temperature reduction, filtration is preferably further included. A small amount of impurities such as by-products and unreacted raw materials were removed by filtration to obtain a second mixed solution. The method of filtration is not particularly limited in the present invention, and a filtration method known to those skilled in the art may be used.
And (3) after a second mixed solution is obtained, mixing the second mixed solution with alkali liquor, and reacting to obtain the diamino nitrogen-containing aromatic heterocyclic compound with the structure shown in the formula (II).
The alkali liquor is preferably one of aqueous solution of sodium hydroxide, aqueous solution of potassium carbonate, aqueous solution of sodium carbonate, ammonia water, triethylamine and triethanolamine. The concentration of the alkali solution is not particularly limited in the present invention, and the concentration of the alkali solution known to those skilled in the art can be used. In certain embodiments of the invention, the concentration of the lye is 25 wt%.
In the invention, the pH value of the solution after the reaction is preferably 7-8. In certain embodiments of the invention, the pH of the reacted solution is 7.
The temperature of the reaction is preferably room temperature. The reaction time is not particularly limited in the present invention, and the reaction can be stopped when the pH of the obtained first mixed solution meets the requirement.
After the reaction, it is preferable to further include filtering and drying the precipitate obtained after the reaction. The method of filtration is not particularly limited in the present invention, and a filtration method known to those skilled in the art may be used. After the filtration, the filtration preferably further comprises washing the filtered product with water. The method of washing with water is not particularly limited in the present invention, and a method of washing with water known to those skilled in the art may be used. The number of washing is not particularly limited, and may be determined according to the actual situation. The method of drying is not particularly limited in the present invention, and a method of drying known to those skilled in the art may be used.
The source of the raw material components used in the present invention is not particularly limited, and may be generally commercially available. The reaction vessel for carrying out the above-mentioned production process is not particularly limited in the present invention. In certain embodiments of the invention, the reaction vessel is a 100mL single neck flask.
The invention provides a preparation method of a diamino nitrogen-containing aromatic heterocyclic compound, which comprises the following steps:
A) mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution;
O2N-R-NO2 (I)；
wherein R is a group comprising a nitrogen-containing aromatic heterocyclic structure;
B) mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution;
C) mixing the second mixed solution with alkali liquor, and reacting to obtain a diamino nitrogen-containing aromatic heterocyclic compound with a structure shown in a formula (II);
H2N-R-NH2 (Ⅱ)；
wherein R is a group including a nitrogen-containing aromatic heterocyclic structure.
The compound with the structure shown in the formula (I) is mixed with inorganic acid, water-soluble organic matters are obtained after reaction, nitro organic matters can be effectively reduced into amino compounds through reduction of reducing agent sulfide, and then the amino compounds are neutralized through alkali liquor, so that the diamino nitrogen-containing aromatic heterocyclic compound with the structure shown in the formula (II) with high yield and purity is obtained. In addition, the preparation method provided by the invention has the advantages of simple and environment-friendly route, low cost and mild reaction conditions, and is suitable for large-scale popularization and application.
Experimental results show that the diamino nitrogen-containing aromatic heterocyclic compound prepared by the preparation method has the yield of not less than 90 percent, even 96 percent; purity (HPLC) > 99.9%.
In order to further illustrate the present invention, the following examples are given to describe the preparation of a diamino nitrogen-containing aromatic heterocyclic compound of the present invention in detail, but should not be construed as limiting the scope of the present invention.
The reagents used in the following examples are all commercially available.
Example 1
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (1), and 2- (4-nitrophenyl) -5-nitrobenzimidazole is obtained.
To a 100mL single neck flask was added 2- (4-nitrophenyl) -5-nitrobenzimidazole (2.84g,0.01mol) and 50mL of water at room temperature, phosphoric acid was added dropwise, and the pH was adjusted to less than 1. Sodium sulfide solid (3.9g, 0.05mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 12 hours. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight of an aqueous sodium carbonate solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.15g of the product 2- (4-aminobenzene) -5-aminobenzimidazole (yield 96%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 11.52(s,1H), 8.08(d,2H), 7.47(d,1H), 7.10(d,1H), 6.62(m,3H), 5.30(s,2H), 5.18(s,2H) ppm.
Example 2
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (2), and the 2- (4-nitrophenyl) -5-nitrobenzoxazole is obtained.
To a 100mL one-neck flask, 2- (4-nitrophenyl) -5-nitrobenzoxazole (3.22g,0.01mol) and 50mL of water were added at room temperature, phosphoric acid was added dropwise, and the pH was adjusted to less than 1. Sodium thiosulfite solid (8.5g, 0.06mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 16 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight of an aqueous sodium carbonate solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.14g of the product 2- (4-aminophenyl) -5-aminobenzoxazole (yield 95%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 7.81(m,3H), 6.90(d,1H), 6.74(m,3H), 6.62(m,3H), 5.28(s,2H),5.10(s,2H) ppm.
Example 3
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (9), and 2,2 '-bis (4-nitrobenzene) -5,5' -biphenyl diimidazole is obtained.
To a 100mL single neck flask, 2 '-bis (4-nitrophenyl) -5,5' -biphenyldiimidazole (4.76g,0.01mol) and 50mL of water were added at room temperature, and then hydrogen sulfuric acid was added to adjust the pH to less than 1. Sodium hydrosulfide solid (11.2g, 0.20mol) is added, the temperature is raised to 100 ℃, and the reaction is continued for 28 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight of an aqueous potassium carbonate solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 3.6g of 2,2 '-bis (4-aminobenzene) -5,5' -biphenyldiimidazole (yield 87%, purity (HPLC) > 99.9%), 1H-NMR (600MHz, DMSO-d 6): 12.46(s,2H), 7.88(d,4H), 7.79-7.64(m,4H), 7.45(d,2H), 6.69(d,4H), 5.60(s,4H) ppm.
Example 4
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (6), and 2, 6-bis (4-nitrobenzene) benzobisoxazole is obtained.
To a 100mL single neck flask, 2, 6-bis (4-nitrophenyl) benzobisoxazole (4.02g,0.01mol) and 50mL of water were added at room temperature, tetrafluoroboric acid was added dropwise, and the pH was adjusted to less than 1. Sodium polysulfide solid (7.8g, 0.10mol) was added and the reaction was continued for 25h at 100 ℃. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 by adding 25 wt% aqueous sodium carbonate solution to obtain 3.1g of 2, 6-bis (4-aminophenyl) benzobisoxazole as a product (yield 90%, purity (HPLC) > 99.9%), 1H-NMR (300MHz, DMSO-d 6): 8.06(s,2H), 7.87(d,4H), 6.71(d,4H), 5.98(s,4H) ppm.
Example 5
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (10), and 2- (4-nitrobenzene) -5-nitropyridine is obtained.
To a 100mL single neck flask, 2- (4-nitrobenzene) -5-nitropyridine (2.45g,0.01mol) and 50mL of water were added at room temperature, hydrochloric acid was added dropwise, and the pH was adjusted to less than 1. Sodium sulfide solid (5.46g, 0.07mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 15 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight aqueous sodium hydroxide solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 1.79g of the product 2- (4-aminobenzene) -5-aminopyridine (yield 97%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 7.93(d,1H),7.59(d,2H),7.41(d,1H),6.93(dd,1H),6.57(d,2H),5.17(s,2H),5.12(s,2H) ppm.
Example 6
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (13), and 2- (4-nitrobenzene) -5-nitropyrimidine is obtained.
To a 100mL single neck flask was added 2- (4-nitrobenzene) -5-nitropyrimidine (2.46g,0.01mol) and 50mL of water at room temperature, sulfuric acid was added dropwise and the pH was adjusted to less than 1. Sodium hydrosulfide solid (6.72g, 0.12mol) is added, the temperature is raised to 100 ℃, and the reaction is continuously carried out for 16 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight aqueous sodium hydroxide solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 1.75g of the product 2- (4-aminobenzene) -5-aminopyrimidine (yield 94%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 8.02(s,2H),7.80(d, 2H), 6.48(d, 2H), 5.28(s,2H),5.23(s,2H) ppm.
Example 7
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (15), and 2, 5-di (4-nitrobenzene) pyridine is obtained.
2, 5-bis (4-nitrophenyl) pyridine (3.21g,0.01mol) and 50mL of water were added to a 100mL single-neck flask at room temperature, and hydrochloric acid was added dropwise to adjust the pH to less than 1. Sodium sulfide solid (6.67g, 0.08mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 20 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight aqueous sodium hydroxide solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.48g of 2, 5-bis (4-aminophenyl) pyridine (yield 95%, purity (HPLC) > 99.9%), 1H-NMR. delta. (600MHz, DMSO-d 6): 8.74(d,1H), 7.87(dd,1H), 7.81(d,2H), 7.73(d,1H), 7.43(d,2H), 6.67(d,2H), 6.64(d,2H), 5.39(s,2H), 5.30(s,2H) ppm.
Example 8
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (16), and 2, 5-di (4-nitrobenzene) pyridine is obtained.
2, 5-bis (4-nitrophenyl) pyrimidine (3.22g,0.01mol) and 50mL of water were added to a 100mL, single-neck flask at room temperature, sulfuric acid was added dropwise, and the pH was adjusted to less than 1. Sodium disulphide solid (8.8g, 0.08mol) was added and the reaction was continued for 22h at 100 ℃. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight aqueous sodium hydroxide solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.51g of the product 2, 5-bis (4-aminophenyl) pyrimidine (yield 96%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 8.92(s,2H), 8.08(d,2H,4Hz), 7.47(d,2H), 6.67(d,2H), 6.62(d,2H), 5.61(s,2H), 5.39(s,2H) ppm.
Example 9
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (17), and 2-nitro-5- (2-hydroxy-4-nitrophenyl) benzimidazole is obtained.
To a 100mL single neck flask, 2-nitro-5- (2-hydroxy-4-nitrophenyl) benzimidazole (3.00g,0.01moL) and 50mL of water were added at room temperature, hypophosphorous acid was added dropwise, and the pH was adjusted to less than 1. Ammonium sulfide solid (6.8g, 0.10mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 24 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with 25% by weight of an aqueous potassium carbonate solution, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.25g of the product 2-amino-5- (2-hydroxy-4-aminophenyl) benzimidazole (yield 94%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 11.2(s,1H), 9.68(d,1H), 7.47(m,2H), 7.00(d,1H), 6.55(m,2H), 6.81(d,1H), 5.28(s,2H),5.10(s,2H) ppm.
Example 10
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (20), and 2, 6-bis (2-hydroxy-4-nitrophenyl) benzobisoxazole is obtained.
To a 100mL single neck flask, 2, 6-bis (2-hydroxy-4-nitrophenyl) benzobisoxazole (4.34g,0.01mol) and 50mL water were added at room temperature, hypophosphorous acid was added dropwise, and the pH was adjusted to less than 1. Ammonium sulfide solid (3.4g, 0.05mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 25 h. After cooling to room temperature, filtration was carried out, and the filtrate was neutralized to pH 7 with ammonia water, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 3.54g of the product 2, 6-bis (2-hydroxy-4-aminophenyl) benzobisoxazole (yield 93%, purity (HPLC) > 99.9%), 1H-NMR δ (300MHz, DMSO-d 6): 9.55(s,2H), 7.44(d,2H), 7.28(d,2H), 6.50(d,2H), 6.12(d,2H), 5.20(s,4H) ppm.
Example 11
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (21), and 2- (2-hydroxy-4-nitrophenyl) -5-nitropyridine is obtained.
To a 100mL single-neck flask, 2- (2-hydroxy-4-nitrophenyl) -5-nitropyridine (2.61g,0.01mol) and 50mL of water were added at room temperature, hypophosphorous acid was added dropwise, and the pH was adjusted to less than 1. Ammonium sulfide solid (8.16g, 0.12mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 21 h. After cooling to room temperature, filtration was carried out, triethanolamine was added to the filtrate to neutralize the filtrate to pH 7, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 1.95g of the product 2- (2-hydroxy-4-aminophenyl) -5-aminopyridine (yield 97%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 9.59(s,2H), 7.78(d,2H), 7.67(d,1H), 6.33(m,2H), 5.29(s,2H) ppm.
Example 12
In the compound with the structure shown in the formula (I), R is the structure shown in the formula (24), and 2- (2-hydroxy-4-nitrophenyl) -5- (4-nitrophenyl) pyrimidine is obtained.
To a 100mL one-neck flask, 2- (2-hydroxy-4-nitrophenyl) -5- (4-nitrophenyl) pyrimidine (3.38g,0.01mol) and 50mL of water were added at room temperature, sulfurous acid was added dropwise, and the pH was adjusted to less than 1. Ammonium sulfide solid (6.8g, 0.10mol) was added, the temperature was raised to 100 ℃ and the reaction was continued for 18 h. After cooling to room temperature, filtration was carried out, triethylamine was added to the filtrate to neutralize the solution to pH 7, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 3.44g of the product 2- (2-hydroxy-4-aminophenyl) -5- (4-aminophenyl) pyrimidine (yield 92%, purity (HPLC) > 99.9%), 1H-NMR. delta. (300MHz, DMSO-d 6): 9.55(s,1H), 8.92(s,2H), 7.47(m,3H), 6.62(m,3H), 6.12(d,1H), 5.39(s,2H) ppm.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A preparation method of a diamino nitrogen-containing aromatic heterocyclic compound comprises the following steps:
A) mixing a compound with a structure shown in a formula (I), water and inorganic acid, and reacting to obtain a first mixed solution;
O2N-R-NO2 （I）；
wherein R is a group of one structure of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure; or R is a group formed by combining one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure with a benzene ring structure; or R is a group which is a combination of one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure and a substituted benzene ring structure;
the inorganic acid is selected from one of hydrochloric acid, sulfuric acid, phosphoric acid, sulfurous acid, hypophosphorous acid, hydrosulfuric acid, tetrafluoroboric acid and hexafluorophosphoric acid; B) mixing the first mixed solution with sulfide, and reacting to obtain a second mixed solution;
the sulfide is selected from one or more of sodium hydrosulfide solid, sodium sulfide solid, sodium disulfide solid, sodium polysulfide solid, ammonium sulfide solid, sodium bisulfite solid, sodium sulfite solid, sodium thiosulfate solid and sodium dithionite solid;
C) mixing the second mixed solution with alkali liquor, and reacting at room temperature to obtain a diamino nitrogen-containing aromatic heterocyclic compound with a structure shown in a formula (II);
H2N-R-NH2 （Ⅱ）；
wherein R is a group of one structure of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure; or R is a group formed by combining one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure with a benzene ring structure; or R is a group in which one of a benzimidazole ring structure, a benzoxazole ring structure, a pyridine ring structure and a pyrimidine ring structure is combined with a substituted benzene ring structure.
2. The method according to claim 1, wherein the substituent is one or more of alkyl, aryl, hydroxyl, alkoxy, phenoxy, cyano, amino, amido, ester, acyl, halogen and carboxyl.
3. The method of claim 1, wherein R is selected from one of formula (1) to formula (24):
4. the method according to claim 1, wherein the alkali solution is one selected from the group consisting of an aqueous solution of sodium hydroxide, an aqueous solution of potassium carbonate, an aqueous solution of sodium carbonate, aqueous ammonia, triethylamine and triethanolamine.
5. The preparation method according to claim 1, wherein the compound having the structure shown in formula (I) and water are used in an amount ratio of 2-25 g: 100 mL;
the molar ratio of the compound having the structure shown in the formula (I) to the sulfide is 1: 2 to 30.
6. The production method according to claim 1, wherein the pH value of the first mixed solution is not higher than 2.
7. The preparation method according to claim 1, wherein in the step B), the reaction temperature is 95-105 ℃, and the reaction time is 10-30 h.
8. The method according to claim 1, wherein in the step C), the pH value of the mixed solution is 7 to 8.
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