CN108553088B - OCT system - Google Patents
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- CN108553088B CN108553088B CN201810450174.6A CN201810450174A CN108553088B CN 108553088 B CN108553088 B CN 108553088B CN 201810450174 A CN201810450174 A CN 201810450174A CN 108553088 B CN108553088 B CN 108553088B
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- 238000003384 imaging method Methods 0.000 claims abstract description 81
- 239000013307 optical fiber Substances 0.000 claims abstract description 11
- 230000008859 change Effects 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 11
- 230000009466 transformation Effects 0.000 claims description 4
- 238000012377 drug delivery Methods 0.000 claims description 2
- 238000012014 optical coherence tomography Methods 0.000 description 90
- 230000000694 effects Effects 0.000 description 6
- 230000001360 synchronised effect Effects 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 230000009347 mechanical transmission Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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Abstract
Disclosed is an OCT system comprising a data acquisition device (1), the data acquisition device (1) comprising a light emitting unit (4) emitting reflected light and an optical fiber (5), the optical fiber (5) moving with an OCT imaging catheter (2) for continuous scanning, the OCT imaging catheter (2) having one or more positioning units (10) extending axially from an outer diameter of the OCT imaging catheter such that an electrical signal generates an abrupt change signal at a predetermined position, a data processing device (3) comprising a balance detector (6), the reflected light emitted by the light emitting unit (4) generating an electrical signal related to tissue depth via the balance detector (6), a data processing unit (7) forming the electrical signal generated by the balance detector (6) into a two-dimensional graphical frame, a synchronization unit (8) determining a frame synchronization position based on the abrupt change signal generated at the predetermined position of the OCT imaging catheter (2), and an image generating unit (9) generating a three-dimensional image based on the frame synchronization position.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an OCT system.
Background
Optical coherence tomography (Optical Coherence Tomography, OCT for short) has been widely used in the field of medical diagnosis, OCT is an imaging technique integrating multiple leading edge subjects of photoelectric and high-speed data acquisition and image processing based on optics, electronics and computer technology science, and OCT has been attracting attention by virtue of its advantages of high resolution, high-speed imaging, and the like. In OCT systems, synchronization is very important, which ensures the correct three-dimensional reorganization. There are generally two approaches to address frame synchronization: firstly, synchronizing motor sensors; and (II) adding an additional physical device in the rotating system, and sending out a synchronous signal at a certain fixed position on the rotating surface.
Patent document 1 discloses an OCT imaging method, which includes the steps of: an outer joint (7) of an OCT imaging catheter (14) is connected to a mechanical transmission (12) in the OCT system, the mechanical transmission (12) reading chip data provided on the outer joint (7), the data comprising a catheter length of the OCT imaging catheter; a coherent light source (10) in the OCT system is divided into a first optical signal for detecting tissues and a second optical signal for serving as a reference through an optical fiber beam splitter (11), and the OCT system automatically sets the reference arm length of the second optical signal based on the read catheter length so as to coherently detect the first optical signal; a mechanical drive (12) actuates rotational and axial movement of the OCT imaging catheter (14) to perform lateral and axial scans to establish a spatial image of tissue. The patent is a prior patent document of the application, and the chip contains catheter parameters, so that OCT imaging time can be saved, errors generated by scanning are avoided, and the precision of a space image is further improved.
Patent document 2 discloses an intravascular ultrasound-OCT probe system for imaging an inside of an arterial vessel, comprising an imaging probe composed of an elongated hollow catheter, a distal end portion, a middle portion, and a proximal end portion in the elongated hollow catheter being sequentially provided with a driving assembly, an imaging catheter, and an interface module, the interface module being connected with an image processing and display system; the image processing and displaying system comprises an OCT tomographic imaging module, an ultrasonic tomographic imaging module, a synchronous control unit, an image processing module, an image displaying module and a user interface; the driving assembly comprises an ultrasonic motor and an acousto-optic reflector, the ultrasonic motor consists of an ultrasonic motor stator and an ultrasonic motor rotor, the ultrasonic motor stator is fixed at the bottommost part of the far end part of the slender hollow catheter, the ultrasonic motor rotor is fixed on the acousto-optic reflector, and the ultrasonic motor is connected with a synchronous control unit of the image processing and displaying system through a motor driving wire so that the ultrasonic motor can rotate around the axial direction in the slender hollow catheter; the imaging catheter includes an OCT probe catheter portion and an ultrasound imaging catheter portion; the OCT probe catheter part consists of a single-mode fiber and a green lens, the green lens is encapsulated at the joint of the middle part and the distal end part of the slender hollow catheter and is connected with the single-mode fiber, the single-mode fiber is encapsulated at the interface module through the middle part of the slender hollow catheter and is connected with an OCT tomographic imaging processing module of an image processing and displaying system through the interface module, the OCT tomographic imaging processing module guides optical imaging energy to the distal end of the single-mode fiber through the interface module, deflects an optical path by 90 degrees through the acousto-optic reflector and receives reflected optical energy signals returned along an original optical path to be guided back into the image processing and displaying system. The patent driving part utilizes an ultrasonic motor without electromagnetic interference, but the patent motor sensor is synchronous, and in the actual imaging process, various conditions such as hysteresis, pause, non-uniformity and the like can occur when the motor is rotated through transmission connection, so that the real condition of the imaging part can not be embodied.
Patent document 3 discloses an OCT imaging catheter of high imaging quality, including access section (1), the one end of the rotatory withdrawal device of external OCT system of keeping away from on access section (1) is provided with central tube (3), the upper end of central tube (3) is provided with advances notes section (2), and the one end of keeping away from access section (1) on central tube (3) is provided with intervenes section (4). The lubricating layer is arranged between the outer protective tube and the spring tube of the patent catheter, and the friction between the spring tube and the outer protective tube is reduced due to the lubricating layer, so that distortion caused by high-speed rotation is reduced, better blood vessel images can be obtained, but the patent only can reduce adverse effects caused by the high-speed rotation, various conditions such as hysteresis, pause and non-uniformity caused by rotation can not be avoided, and the real condition of an imaging part can not be reflected.
In summary, in OCT synchronization, the synchronization device is in the driving system, such as the motor and the connector, and various situations such as hysteresis, pause, non-uniformity and the like can occur after the rotation is connected through the transmission, such as the torsion spring, which cannot embody the real situation of the imaging part, so that the synchronization precision is low and the three-dimensional imaging effect is poor.
Prior art literature
Patent literature
Patent document 1: chinese patent publication CN107752985a
Patent document 2: chinese patent publication CN107713986a
Patent document 3: chinese patent publication CN106691506a
Disclosure of Invention
Problems to be solved by the invention
As described above, the present invention needs to provide an OCT system that can avoid various situations such as hysteresis, pause, and unevenness due to transmission caused by high-speed rotation, and cannot embody the real situation of an imaging portion, improve synchronization accuracy, and enhance three-dimensional imaging effects.
Solution to the problem
The present inventors have made intensive studies to achieve the above object, and specifically, the present invention provides an OCT system comprising
A data acquisition device, which comprises a light-emitting unit for emitting reflected light and an optical fiber, wherein the optical fiber moves along with the OCT imaging catheter to perform continuous scanning,
an OCT imaging catheter, one or more positioning units extending axially from the outer diameter of the OCT imaging catheter to generate an abrupt signal at a predetermined position,
a data processing device, which comprises,
the balance detector, the reflected light emitted by the light emitting unit generates an electric signal related to the tissue depth through the balance detector,
a data processing unit for forming the electric signals generated by the balance detector into two-dimensional graphic frames,
a synchronization unit that determines a frame synchronization position based on an abrupt signal generated at a predetermined position of the OCT imaging catheter,
and an image generation unit that generates a three-dimensional image based on the frame synchronization position.
In the OCT system, the data processing unit includes a fourier transform unit.
In the OCT system, one or more positioning units are disposed at predetermined positions of the OCT imaging catheter outer diameter and the positioning units extend in the axial direction such that the reflection of the optical signal at the predetermined positions is different from other positions of the OCT imaging catheter outer diameter.
In the OCT system, the positioning unit is a groove that is disposed at a predetermined position of an outer diameter of the OCT imaging catheter and extends in an axial direction.
In the OCT system, the positioning unit is a protrusion that is disposed at a predetermined position of an outer diameter of the OCT imaging catheter and extends in an axial direction.
In the OCT system, the material refractive index of the positioning unit is different from the OCT imaging catheter material.
In the OCT system, the positioning unit is a metal wire that is disposed at a predetermined position of an outer diameter of the OCT imaging catheter and extends in an axial direction.
In the OCT system, a groove extending along the axial direction is arranged at a preset position of the outer diameter of the OCT imaging catheter, and circular tubes made of different materials are arranged on the groove.
In the OCT system, a drill or a drug delivery channel is provided on the OCT imaging catheter.
In the OCT system described, the data processing means comprise a memory.
The high-speed sampling system continuously samples, carries out Fourier transformation on signals from the balance detector, converts frequency domain scanning into space organization information, finds a frame synchronization position according to signal mutation after data calculation, avoids various conditions such as delay, pause and non-uniformity of transmission caused by high-speed rotation, reflects the real condition of an imaging part, finds the synchronization position by combining the signal mutation with a calculation mode, improves the synchronization precision, enhances the three-dimensional imaging effect, and is beneficial to making the mechanical structure of the rotating system smaller.
The foregoing description is only an overview of the technical solutions of the present invention, to the extent that it can be implemented according to the content of the specification by those skilled in the art, and to make the above-mentioned and other objects, features and advantages of the present invention more obvious, the following description is given by way of example of the present invention.
Drawings
Fig. 1 shows a schematic diagram of the OCT system according to one embodiment of the present invention.
Fig. 2 shows a schematic structural view of an OCT imaging catheter of the OCT system according to one embodiment of the present invention.
Fig. 3 shows a schematic structural view of an OCT imaging catheter of the OCT system according to another embodiment of the present invention.
Fig. 4 shows a schematic structural view of an OCT imaging catheter of the OCT system according to still another embodiment of the present invention.
Fig. 5 shows a schematic structural view of an OCT imaging catheter of the OCT system according to still another embodiment of the present invention.
Fig. 6 shows a schematic structural view of an OCT imaging catheter of the OCT system according to yet another embodiment of the present invention.
Symbol description
1. Data acquisition device
2 OCT imaging catheter
3. Data processing apparatus
4. Light-emitting unit
5. Optical fiber
6. Balance detector
7. Data processing unit
8. Synchronization unit
9. Image generating unit
10. Positioning unit
Detailed Description
Specific embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. Those of skill in the art will understand that a person may refer to the same component by different names. The description and claims do not identify differences in terms of components, but rather differences in terms of the functionality of the components. As used throughout the specification and claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description hereinafter sets forth a preferred embodiment for practicing the invention, but is not intended to limit the scope of the invention, as the description proceeds with reference to the general principles of the description. The scope of the invention is defined by the appended claims.
For the purpose of facilitating an understanding of the embodiments of the invention, reference will now be made to the drawings of several embodiments illustrated in the drawings, and the accompanying drawings are not to be taken as limiting the embodiments of the invention.
Specifically, a schematic diagram of an OCT system is shown in fig. 1. An OCT system includes
The data acquisition device 1, the data acquisition device 1 comprises a light emitting unit 4 emitting reflected light and an optical fiber 5, the optical fiber 5 moves along with the OCT imaging catheter 2 to perform continuous scanning,
the OCT imaging catheter 2, the one or more positioning units 10 with an axially extending outer diameter of the OCT imaging catheter, causes the electrical signal to generate a sudden change signal at a predetermined location,
the data processing means 3, which comprises,
the balance detector 6, the reflected light from the light emitting unit 4 passes through the balance detector 6 to generate an electrical signal related to the tissue depth,
a data processing unit 7 for forming the electrical signals generated by the balance detector 6 into a two-dimensional pattern frame,
a synchronization unit 8 that determines a frame synchronization position based on an abrupt signal generated at a predetermined position of the OCT imaging catheter 2,
an image generation unit 9 that generates a three-dimensional image based on the frame synchronization position.
In the OCT system, the reflected light generates an electric signal related to tissue depth after passing through the balance detector, the optical fiber rotates along with the catheter, a two-dimensional section is generated through Fourier transformation and related data processing, and then continuous section scanning is performed through the movement of the whole system to finally generate a three-dimensional image, wherein a straight line mark is carved on the outer tube of the catheter, or a positioning unit is arranged by plating a very thin metal or other materials, so that the optical signal generates reflection different from other positions at the point. Since the catheter is uniform in material and has no other reflections, the reflections at the catheter wall are uniform and very easy to detect, and the catheter outer diameter is uniform, so that abrupt changes can be detected. The high-speed sampling system continuously samples, performs Fourier transform on the signals from the balance detector, and converts the frequency domain scanning into spatial organization information. And after the data calculation, the frame synchronization position is found according to the signal mutation. The invention avoids various conditions such as hysteresis, pause, non-uniformity and the like caused by high-speed rotation, reflects the real condition of an imaging part, finds out the synchronous position by combining a signal mutation calculation mode, improves the synchronous precision, enhances the three-dimensional imaging effect, and is beneficial to making the mechanical structure of a rotation system smaller.
In a preferred embodiment of the OCT system according to the present invention, the data processing means comprise a fourier transformation unit.
In an OCT imaging catheter of the OCT system, the positioning unit 10 is disposed at a predetermined position of the outer diameter of the OCT imaging catheter 2 and the positioning unit 10 extends in the axial direction so that the reflection of the optical signal generated at the predetermined position is different from other positions of the outer diameter of the OCT imaging catheter.
Fig. 2 shows a schematic structural view of an OCT imaging catheter of the OCT system according to an embodiment of the present invention, and the positioning unit 10 is a groove disposed at a predetermined position of an outer diameter of the OCT imaging catheter 2 and extending in an axial direction.
Fig. 3 shows a schematic structural view of an OCT imaging catheter of the OCT system according to another embodiment of the present invention, and the positioning unit 10 is a protrusion disposed at a predetermined position of an outer diameter of the OCT imaging catheter 2 and extending in an axial direction. In a preferred embodiment of the invention, the material of the protrusions is different from the OCT imaging catheter material.
Fig. 4 shows a schematic structural view of an OCT imaging catheter of the OCT system according to another embodiment of the present invention, where a predetermined position of the outer diameter of the OCT imaging catheter 2 is provided with a groove extending in the axial direction, and the groove is provided with a round tube made of a different material.
Fig. 5 shows a schematic structural view of an OCT imaging catheter of the OCT system according to another embodiment of the present invention, where the refractive index of the material of the positioning unit 10 is different from that of the OCT imaging catheter.
Fig. 6 shows a schematic structural view of an OCT imaging catheter of the OCT system according to another embodiment of the present invention, and the positioning unit 10 is a metal wire disposed at a predetermined position of an outer diameter of the OCT imaging catheter 2 and extending in an axial direction. Preferably, the positioning unit 10 may be a plating line.
In a preferred embodiment of the present invention, a drill or an administration channel is provided on the OCT imaging catheter 2.
In a preferred embodiment of the invention the data processing means 3 comprise a memory.
Industrial applicability
The OCT system of the present invention can be manufactured and used in the field of medical devices.
Although the embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to the above-described specific embodiments and application fields, and the above-described specific embodiments are merely illustrative, and not restrictive. Those skilled in the art, having the benefit of this disclosure, may effect numerous forms of the invention without departing from the scope of the invention as claimed.
Claims (8)
1. An OCT system, comprising:
the data acquisition device (1), the data acquisition device (1) comprises a light emitting unit (4) for emitting reflected light and an optical fiber (5), the optical fiber (5) moves along with the OCT imaging catheter (2) to carry out continuous scanning,
an OCT imaging catheter (2) with one or more positioning units (10) extending axially from the outer diameter of the OCT imaging catheter such that the electrical signal produces a sudden change signal at a predetermined location,
a data processing device (3);
the data processing apparatus includes:
a balance detector (6), wherein the reflected light emitted by the light emitting unit (4) passes through the balance detector (6) to generate an electric signal related to tissue depth,
a data processing unit (7) for forming the electrical signals generated by the balance detector (6) into a two-dimensional pattern frame,
a synchronization unit (8) for determining a frame synchronization position based on an abrupt change signal generated at a predetermined position of the OCT imaging catheter (2),
an image generation unit (9) that generates a three-dimensional image based on the frame synchronization position,
in the OCT system, one or more positioning units (10) are arranged at a predetermined position of the outer diameter of the OCT imaging catheter (2) and the positioning units (10) extend in the axial direction so that the reflection generated by the optical signal at the predetermined position is different from the reflection generated by the other positions of the outer diameter of the OCT imaging catheter,
the material refractive index of the positioning unit (10) is different from the OCT imaging catheter material.
2. OCT system according to claim 1, characterized in that the data processing unit (7) comprises a fourier transformation unit.
3. OCT system according to claim 1, characterized in that the positioning unit (10) is a groove arranged at a predetermined position of the outer diameter of the OCT imaging catheter (2) and extending in the axial direction.
4. OCT system according to claim 1, characterized in that the positioning unit (10) is a protrusion arranged at a predetermined position of the outer diameter of the OCT imaging catheter (2) and extending in the axial direction.
5. OCT system according to claim 1, characterized in that the positioning unit (10) is a wire arranged at a predetermined position of the outer diameter of the OCT imaging catheter (2) and extending in the axial direction.
6. OCT system according to claim 1, characterized in that the OCT imaging catheter (2) is provided with axially extending grooves at predetermined locations of its outer diameter, said grooves being provided with round tubes of different materials.
7. OCT system according to claim 1, characterized in that a drill bit or a drug delivery channel is provided on the OCT imaging catheter (2).
8. OCT system according to claim 1, characterized in that the data processing means (3) comprise a memory.
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DE102005022901A1 (en) * | 2005-05-18 | 2006-11-23 | Siemens Ag | Instrumentation section orientation procedure takes two dimensional image of object area and recognises marking pattern |
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