CN108542892A - The preparation method of amoxil capsule - Google Patents
The preparation method of amoxil capsule Download PDFInfo
- Publication number
- CN108542892A CN108542892A CN201810508456.7A CN201810508456A CN108542892A CN 108542892 A CN108542892 A CN 108542892A CN 201810508456 A CN201810508456 A CN 201810508456A CN 108542892 A CN108542892 A CN 108542892A
- Authority
- CN
- China
- Prior art keywords
- capsule
- amoxicillin
- solidify liquid
- preparation
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention discloses the preparation methods of amoxil capsule, include the following steps：(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, stirring constant temperature water bath carries out homogenization and obtains mixed liquor for a period of time, mixed liquor is sprayed in solidify liquid, the drop ejected is contacted with solidify liquid at once, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 15~20%, and drop isolates Amoxicillin micro-capsule after curing 10~15min in solidify liquid, and it is spare to clean dehydration and drying.The present invention is improved by the form to the Amoxicillin agent in amoxil capsule, amoxicillin granules is especially modified to micro-capsule, while being improved to the preparation method of Amoxicillin micro-capsule so that the particle diameter distribution of Amoxicillin micro-capsule is narrow, and embedding rate is big.The research of Conformance Assessment has been done in the present invention and reference agent, and 4 In Vitro Dissolution curve F2 values of own product and reference preparation are all higher than 50, has similitude.
Description
Technical field
The present invention relates to pharmaceutical fields, and in particular to a kind of preparation method of amoxil capsule.
Background technology
Amoxicillin also known as amoxicillin or Amoxicillin are that a kind of most common semi-synthetic penicillins wide spectrum β-is interior
Amides antibiotic is a kind of white powder, and half-life period is about 61.3 minutes.Stablize in acid condition, gastrointestinal tract absorptivity
Up to 90%.Amoxicillin bactericidal effect is strong, and the ability of penetration cell film is also strong.It is widely used at present oral semi-synthetic
One of penicillin, preparation have capsule, tablet, granule, dispersible tablet etc., are often shared now with clavulanic acid and dispersion is made
Piece.Exactly because half-life short in vivo, and drained comparatively fast through urinary tract, drug availability is low, takes rear blood concentration and reaches
Peak time is about 2 hours, and blood concentration is rapidly decreased to minimum inhibitory concentration hereinafter, needing to take in drug again and could maintain later
Blood concentration, it is clear that the times for spraying of general Amoxicillin medicament is more.For such situation, prior art preparation has gone out energy
Enough control the sustained release preparation of Amoxicillin rate of release.But there is setting in glue in existing sustained release preparation especially capsule preparations
The Amoxicillin in intracapsular portion exists in the form of granules, although its external capsule has centainly the dissolving of Amoxicillin
Slow release effect, but its solution rate could promote slow release effect there is still a need for being controlled.
Therefore clinically need a kind of Amoxicillin existence form that can be improved in amoxil capsule further to carry
Rise the dosage form of slow release effect.
Invention content
The purpose of the present invention is to provide a kind of preparation method of amoxil capsule, which passes through to A Moxi
The improvement of Wymox form in woods capsule so that the particle diameter distribution of Amoxicillin micro-capsule is narrow, and embedding rate is big.The present invention
Amoxil capsule and reference preparation have similitude, 4 In Vitro Dissolutions of amoxil capsule of the invention and reference preparation
Curve F2 values are all higher than 50.
The present invention is achieved through the following technical solutions：
The preparation method of amoxil capsule, includes the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, constant temperature water bath is stirred
A period of time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is at once and solidify liquid
Contact, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 15~20%, and drop is in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min of solidification, it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight
It is interior.
The second wall material can be added in solidify liquid.
Solidify liquid is calcium chloride solution.
The wall material of Amoxicillin micro-capsule is Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, beta-cyclodextrin.
Second wall material is ethyl cellulose and sodium carboxymethylcellulose.
Second wall material, wall material, Amoxicillin mass ratio are 2:1:0.8~1.
The mass concentration of solidify liquid is 15~18%.
The preparation of micro-capsule and the preparation difference of the prior art are in the present invention：The present invention is directly and solid after drop ejection
Change liquid contact, so that drop enables to drop to cure uniform force under the action of solidify liquid and air, accelerates cured same
When and enable to droplet particles mellow and full, particle diameter distribution is narrow, even particle size, and the single defect in surface is few, and embedding rate is big,
Cause molding micro-capsule surface area smaller in this way.Existing drop one spray directly by gravity cause drop single first by
Gravity and the guiding deformation of a degree of gravity occurs, cause follow-up particle diameter distribution wider.It is passed through from solidify liquid bottom
Air, which can play the role of also residing in, can stir solidify liquid so that solidify liquid gives drop shearing force appropriate.The present invention
Middle drop ejection can be in the top of solidify liquid, and drop is to be sprayed straight down.
The second wall material is added in solidify liquid, drop is enabled to be wrapped up for the second time, that is, provides outside the drop second layer
Shell improves slow releasing function.
The wall material of Amoxicillin may be selected to be suitble to its any materials.Arabic gum, sea are selected in the present invention
Mosanom or hydroxypropyl methyl cellulose, beta-cyclodextrin.Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, β-
The mass ratio of cyclodextrin is with 3:3：1 is more suitable.Second wall material selects ethyl cellulose and sodium carboxymethylcellulose.Carboxymethyl is fine
The plain sodium of dimension plays the role of promoting Amoxicillin dissolving, in the presence of the second wall material, it is necessary to appropriate to promote the molten of Amoxicillin
Xie Du so that its slow release effect obtains a degree of balance.Ethyl cellulose and sodium carboxymethylcellulose mass ratio are 3：1 compared with
It is suitable.
In the present invention wall material solution according to conventional aqueous preparation method.Solidify liquid is not limited to chlorine in the present invention
Change calcium, other suitable solidify liquids can be applicable in.Wall material mass concentration is 1.5~3%.Emulsifier is the common breast in this field
Agent can be that monoglyceride either takes charge of temperature or tween etc..
Compared with prior art, the present invention having the following advantages and advantages：
The present invention is improved by the form to the Amoxicillin agent in amoxil capsule, especially by Amoxicillin
Particle is modified to micro-capsule, while being improved to the preparation method of Amoxicillin micro-capsule so that the grain size of Amoxicillin micro-capsule point
Cloth is narrow, and embedding rate is big, improves slow release effect.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiment, the present invention is made
Further to be described in detail, exemplary embodiment of the invention and its explanation are only used for explaining the present invention, are not intended as to this
The restriction of invention.
Embodiment 1
The preparation method of amoxil capsule, includes the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, constant temperature water bath is stirred
A period of time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is at once and solidify liquid
Contact, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 20%, and drop cures in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min, and it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight
It is interior.
Wall material solution mass concentration is 2.5%, and the mass ratio of wall material and Amoxicillin is 1:0.8.
Wall material is Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, beta-cyclodextrin.
Embodiment 2
The preparation method of amoxil capsule, includes the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, constant temperature water bath is stirred
A period of time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is at once and solidify liquid
Contact, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 15%, and drop cures in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min, and it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight
It is interior.
Wall material solution mass concentration is 2.5%, and the mass ratio of wall material and Amoxicillin is 1:1.
Wall material is Arabic gum, sodium alginate, beta-cyclodextrin.
Embodiment 3
The preparation method of amoxil capsule, includes the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, constant temperature water bath is stirred
A period of time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is at once and solidify liquid
Contact, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 18%, and drop cures in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min, and it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight
It is interior.
Wall material solution mass concentration is 2.5%, and the mass ratio of wall material and Amoxicillin is 1:0.8.
Wall material is Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, beta-cyclodextrin.
Embodiment 4
The preparation method of amoxil capsule, includes the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, constant temperature water bath is stirred
A period of time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is at once and solidify liquid
Contact, and it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 18%, and drop cures in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min, and it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight
It is interior.
Wall material solution mass concentration is 2.5%, and the mass ratio of wall material and Amoxicillin is 1:0.8.
Wall material is Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, beta-cyclodextrin.Second wall material is that ethyl is fine
Dimension element and sodium carboxymethylcellulose.Embodiment 1- embodiments 4 are to spray drop straight down.
The Amoxicillin micro-capsule prepared with embodiment 3 carries out performance characterization to it.The shape of micro-capsule is round or close
Like circle, particle diameter distribution is narrow.Particle diameter distribution such as the following table 1：
| Particle diameter micron | 100~112 | 121~130 | 132~140 |
| Distribution | 81.2% | 10.9% | 7.9% |
The embedding rate statistics of embodiment 1-4 is as follows：
| Micro-capsule is molded situation | Embedding rate % | |
| Embodiment 1 | Encystation, round or approximate circle, even particle size | 89.01 |
| Embodiment 2 | Encystation, round or approximate circle, even particle size | 90.21 |
| Embodiment 3 | Encystation, round or approximate circle, even particle size | 92.90 |
| Embodiment 4 | Encystation, round or approximate circle, even particle size | 96.24 |
The present invention has made the research of Conformance Assessment of embodiment 3 and reference agent, and own product and reference preparation 4 are external molten
Go out curve F2 values and be all higher than 50, there is similitude.
Above-described specific implementation mode has carried out further the purpose of the present invention, technical solution and advantageous effect
It is described in detail, it should be understood that the foregoing is merely the specific implementation mode of the present invention, is not intended to limit the present invention
Protection domain, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (7)
1. the preparation method of amoxil capsule, which is characterized in that include the following steps：
(1) Amoxicillin micro-capsule is prepared：Wall material solution, Amoxicillin are added in emulsifier solution, one section of constant temperature water bath is stirred
Time carries out homogenization and obtains mixed liquor, and mixed liquor is sprayed in solidify liquid, and the drop ejected is contacted with solidify liquid at once,
And it is passed through 6~8mL/min air from solidify liquid bottom, the mass concentration of solidify liquid is 15~20%, and drop cures in solidify liquid
Amoxicillin micro-capsule is isolated after 10~15min, and it is spare to clean dehydration and drying；
(2) amoxil capsule is prepared：Amoxicillin micro-capsule in step (1) is divided in capsule for medicine by weight.
2. the preparation method of amoxil capsule according to claim 1, which is characterized in that can be added in solidify liquid
Two wall materials.
3. the preparation method of amoxil capsule according to claim 1, which is characterized in that solidify liquid is that calcium chloride is molten
Liquid.
4. the preparation method of amoxil capsule according to claim 1, which is characterized in that the wall material of Amoxicillin micro-capsule
For Arabic gum, sodium alginate or hydroxypropyl methyl cellulose, beta-cyclodextrin.
5. the preparation method of amoxil capsule according to claim 2, which is characterized in that the second wall material is ethyl cellulose
Element and sodium carboxymethylcellulose.
6. the preparation method of amoxil capsule according to claim 1, which is characterized in that the second wall material, wall material, A Mo
XiLin mass ratio is 2:1:0.8~1.
7. the preparation method of amoxil capsule according to claim 1, which is characterized in that the mass concentration of solidify liquid is
15~18%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810508456.7A CN108542892B (en) | 2018-05-24 | 2018-05-24 | Preparation method of amoxicillin capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810508456.7A CN108542892B (en) | 2018-05-24 | 2018-05-24 | Preparation method of amoxicillin capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108542892A true CN108542892A (en) | 2018-09-18 |
| CN108542892B CN108542892B (en) | 2020-03-24 |
Family
ID=63495486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810508456.7A Active CN108542892B (en) | 2018-05-24 | 2018-05-24 | Preparation method of amoxicillin capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108542892B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112370437A (en) * | 2020-10-20 | 2021-02-19 | 好医生药业集团有限公司 | Amoxicillin capsule and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879606A (en) * | 2006-05-02 | 2006-12-20 | 沈阳药科大学 | Preparation of novel drug delivery system based on liquid spray method |
| CN102058533A (en) * | 2009-11-17 | 2011-05-18 | 索绪斌 | Method for preparing liposome micro-capsules and application thereof |
| CN106727351A (en) * | 2016-12-28 | 2017-05-31 | 重庆金邦动物药业有限公司 | Amoxicillin micro-capsule dry suspensoid agent and preparation method thereof |
-
2018
- 2018-05-24 CN CN201810508456.7A patent/CN108542892B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879606A (en) * | 2006-05-02 | 2006-12-20 | 沈阳药科大学 | Preparation of novel drug delivery system based on liquid spray method |
| CN102058533A (en) * | 2009-11-17 | 2011-05-18 | 索绪斌 | Method for preparing liposome micro-capsules and application thereof |
| CN106727351A (en) * | 2016-12-28 | 2017-05-31 | 重庆金邦动物药业有限公司 | Amoxicillin micro-capsule dry suspensoid agent and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 徐晓等: "阿莫西林微囊制备工艺研究", 《中国药物经济学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112370437A (en) * | 2020-10-20 | 2021-02-19 | 好医生药业集团有限公司 | Amoxicillin capsule and preparation method thereof |
| CN112370437B (en) * | 2020-10-20 | 2022-10-21 | 好医生药业集团有限公司 | Amoxicillin capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108542892B (en) | 2020-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2450015T3 (en) | Instant enzyme formulations for animal feed | |
| KR930005322B1 (en) | Spherical seed cores spherical granules and process for production thereof | |
| FI65547C (en) | FOERFARANDE FOER FRAMSTAELLNING AV FOER INHALERING AVSEDDA MJUKA DINATRIUMKROMOGLYKATPELLETAR | |
| WO1999004760A1 (en) | Spherical single-substance particles, medicines and foodstuffs containing the particles, and method of production thereof | |
| KR20030051773A (en) | Cellulosic particle for pharmaceutical preparation | |
| CN105077165B (en) | A kind of preparation method of compound composition salt | |
| AU2002223074B2 (en) | Microgranules based on active principle and method for making same | |
| CN104352441B (en) | A kind of dimethyl fumarate enteric-coated micro-pill and preparation method thereof | |
| CN104146978B (en) | A kind of disulfiram enteric coated tablet and preparation method thereof | |
| CN104971048A (en) | Dimethyl fumarate enteric-coated pellets and preparation method thereof | |
| CN107595782A (en) | A kind of Linezolid dry suspensoid agent and preparation method thereof | |
| CN108542892A (en) | The preparation method of amoxil capsule | |
| CN107837231A (en) | A kind of Nimodipime nanometer method and its dry suspensoid agent | |
| CN107789336A (en) | Azithromycin odor-masking pellet preparation and preparation method thereof | |
| CN110974787B (en) | Posaconazole dry suspension and preparation method thereof | |
| CN106177968A (en) | The preparation of the medicinal microsphere of a kind of silicon dioxide and in the application of pharmaceutical field | |
| CN101732260B (en) | Granules of cefetamet pivoxil hydrochloride and preparation method thereof | |
| CN109481468A (en) | A kind of preparation method of paracetamol caffein atificial cow-bezoar pellet | |
| JP2000296322A (en) | Method and device for fluidizing granular or powdery body | |
| CN104116715A (en) | High-drug loading capacity oxcarbazepine controlled-release granule and preparation method thereof | |
| Kunam et al. | Solubility and dissolution rate enhancement of ezetimibe by solid dispersion and pelletization techniques using soluplus as carrier | |
| EP2838514A1 (en) | Pellets comprising high active ingredient content | |
| WO2009133774A1 (en) | Spherical granules and method of producing the same | |
| CN101485631B (en) | Medicament pellet preparation and preparation method thereof | |
| CN106491514B (en) | Solid pharmaceutical preparation of razaxaban and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |