CN108542596A - Premature rupture of fetal membranes detects protection pad - Google Patents
Premature rupture of fetal membranes detects protection pad Download PDFInfo
- Publication number
- CN108542596A CN108542596A CN201810291342.1A CN201810291342A CN108542596A CN 108542596 A CN108542596 A CN 108542596A CN 201810291342 A CN201810291342 A CN 201810291342A CN 108542596 A CN108542596 A CN 108542596A
- Authority
- CN
- China
- Prior art keywords
- creatinine
- indicators
- protection pad
- reagent
- fetal membranes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003107 Premature Rupture Fetal Membranes Diseases 0.000 title claims description 26
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 100
- 238000001514 detection method Methods 0.000 claims abstract description 51
- 229940109239 creatinine Drugs 0.000 claims abstract description 50
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 48
- 239000007793 ph indicator Substances 0.000 claims abstract description 28
- 239000012052 hydrophilic carrier Substances 0.000 claims abstract description 11
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 9
- 238000002955 isolation Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000002255 enzymatic effect Effects 0.000 claims description 4
- VYWYYJYRVSBHJQ-UHFFFAOYSA-N 3,5-dinitrobenzoic acid Chemical group OC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 VYWYYJYRVSBHJQ-UHFFFAOYSA-N 0.000 claims description 3
- ZBQCCTCQUCOXBO-UHFFFAOYSA-N 4-(4-aminophenyl)-2,2,6,6-tetramethylcyclohex-3-en-1-amine Chemical class CC1(C)C(N)C(C)(C)CC(C=2C=CC(N)=CC=2)=C1 ZBQCCTCQUCOXBO-UHFFFAOYSA-N 0.000 claims description 3
- 108010066906 Creatininase Proteins 0.000 claims description 3
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims description 3
- 239000002390 adhesive tape Substances 0.000 claims description 3
- NUHCTOLBWMJMLX-UHFFFAOYSA-N bromothymol blue Chemical compound BrC1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=C(Br)C(O)=C(C(C)C)C=2)C)=C1C NUHCTOLBWMJMLX-UHFFFAOYSA-N 0.000 claims description 3
- 229920002521 macromolecule Polymers 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 230000004888 barrier function Effects 0.000 claims description 2
- 108010029444 creatinine deiminase Proteins 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 abstract description 24
- 210000002700 urine Anatomy 0.000 abstract description 19
- 206010015856 Extrasystoles Diseases 0.000 abstract description 5
- 210000002219 extraembryonic membrane Anatomy 0.000 abstract description 2
- 230000002028 premature Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000035935 pregnancy Effects 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 210000003754 fetus Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229960003624 creatine Drugs 0.000 description 2
- 239000006046 creatine Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 206010051641 Amniorrhexis Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010056254 Intrauterine infection Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 208000020264 Puerperal Infection Diseases 0.000 description 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 239000002696 acid base indicator Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 210000001691 amnion Anatomy 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000022170 stress incontinence Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/45—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the shape
- A61F13/47—Sanitary towels, incontinence pads or napkins
- A61F13/472—Sanitary towels, incontinence pads or napkins specially adapted for female use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/80—Indicating pH value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
- A61F2013/422—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm the alarm being a colour change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
- A61F2013/427—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm pH indicator
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Food Science & Technology (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to a kind of prematures rupture of fetal membranes to detect protection pad, isolation permeable formation, the detection layers of middle layer and the absorbed layer of lower layer including upper layer, detection layers contain pH indicators and creatinine detection reagent, pH indicators and creatinine detection reagent are fixed on absorbed layer by hydrophilic carrier spaced reciprocally respectively, the color range of pH indicators is pH >=6.5, and the detection threshold value of creatinine detection reagent is 5~40mg/dl.The present invention using pH indicators and the bigeminy reagent of creatinine detection reagent synchronize be detected, specificity is high, effectively excludes interference of the general urine to detection, improves accuracy detect to amniotic fluid, to reduce the probability for detecting false positive.
Description
Technical field
The invention belongs to the technical fields of amniotic fluid detection, and protection pad is detected more particularly to a kind of premature rupture of fetal membranes.
Background technology
Amniorrhexis, amniotic fluid are flowed out by vagina, referred to as " one's water breaks ".Most puerperas tire after ostium of uterus opens big 3~4 centimetres
Film can Natural Ruptures, this belongs to normal condition；But if all numbers of pregnancy are less than 37 weeks, or before actually entering stages of labor, amnion
With regard to Natural Ruptures, and amniotic fluid is caused to be flowed out by vagina, is known as " early stage one's water breaks " or " premature rupture of fetal membranes ".Premature rupture of fetal membranes is to enclose the raw phase most
Common complication can cause early yield to increase, and perinatal feruses case fatality rate increases, and intrauterine infection rate and puerperal infection rate increase.
Although clinically finding that premature rupture of fetal membranes has great importance as early as possible, pregnant woman herself is difficult to sentence in some cases
Disconnected is amniotic fluid or urine.Clinically leakage of amniotic fluid caused by premature rupture of fetal membranes is unconscious, cannot be controlled；And pregnant late period, portion
Divide pregnant woman not only number of micturitions increases, or even stress incontinence can also occur because developmental fetus oppresses bladder.Therefore,
There is an urgent need to develop it is a kind of can in real time and accurate measurements premature rupture of fetal membranes product, in time, accurate judgement lower body outflow liquid
Body is amniotic fluid, for early diagnosing premature rupture of fetal membranes, reduces pregnant woman and fetus risk is extremely important.
The use of the amniotic fluid monitoring sanitary belt that can be dressed is a relatively good selection, city from the promptness of detection
Also occur some amniotic fluid detection protection pads on field, and have multiple patents (CN206044839U, CN105277656A,
CN203089311U, CN204636718U, CN201752403U, CN104297241A, CN101813702B,
CN204154653U).The premature rupture of fetal membranes detecting pad (method) that these patents are told about, mainly include panty liner, permeable formation and
PH test paper forms.The cardinal principle of detection is to use acid-base indicator according to the difference of the pH of urine, vaginal fluid and amniotic fluid
Colour developing is to determine whether be amniotic fluid.But healthy population urine neutrality meta-acid, pH value range 4.8-7.4；Vaginal fluid is inclined
Acid, pH value, may be to 6.5 in infection in 3.8-4.5；Amniotic fluid neutrality meta-alkali, pH ranging from 7.0-7.5；Urine and amniotic fluid
PH value range, which exists, intersects, and is to detect liquid by the single pH detection reagents of the panty liner close to introitus, urethral orifice
No is amniotic fluid, it is difficult to exclude the interference of urine.
Creatinine is product of the muscle in human body metabolism, and 1mg creatinines can be generated per 20g muscle metabolisms.Creatinine is mainly by kidney
Bead filtration excretes.Creatinine is from exogenous and two kinds of endogenous in blood, and exogenous creatinine is meat food generation in vivo
Product after thanking；Endogenous creatinine is the product of internal musculature metabolism.When meat food intake is stablized, the flesh of body
Meat metabolism and not big variation, the generation of creatinine will be more constant.
It is commonly considered as interior green blood creatinine, interior myogenic acid anhydride is the product of human muscle's metabolism.In muscle, creatine mainly leads to
It crosses irreversible non-enzymatic dehydration and gently forms creatinine, then be discharged into blood, with homaluria.Clinically detect serum creatinine
It is common one of the main method for understanding renal function.Serum creatinine normal value standard is：(region and hospital are or not 44-133umol/L
With numerical value difference, man 53~106umol/L, 44~97umol/L of female).
Urine creatinine essentially from blood, excluded with urine after glomerular filtration it is external, renal tubule do not absorb substantially and
Discharge is seldom.It is seldom helpful for evaluation renal function individually to measure concentration of urinary creatinine, but is measured together with serum creatinine, can be used as
The required index of endogenous creatinine clearance rate.The normal value of urine creatinine is：7.1~17.7 mmoles of adult male/twenty-four-hour urine, adult
5.3~15.9 mmoles of women/twenty-four-hour urine；That is 40mg/dl to 130mg/dl.Therefore it is generally acknowledged that (being less than 5mg/ without creatinine
DL liquid) is not urine.
Creatinine in amniotic fluid is the metabolite of muscular tissue creatine, is drained into through the urine of fetus in amniotic fluid, therefore in amniotic fluid
Creatinine value it is related with the maturity of fetal kidney；Content of the creatinine content in early period and blood in amniotic fluid is similar, arrives
Latter half of gestation, content are risen, but overall content is significantly lower than urine.Creatinine normal value in clinical amniotic fluid：
Early pregnancy：70.7~97.2 μm of ol/L (0.8~1.1mg/dl)
Full-term pregnancy：159.1~353.6 μm of ol/L (1.8~4.0mg/dl)
Invention content
Technical problem to be solved by the invention is to provide a kind of prematures rupture of fetal membranes to detect protection pad, distinguishes amniotic fluid and urine, carries
The accuracy of high premature rupture of fetal membranes monitoring.
The technical solution adopted by the present invention to solve the technical problems is to provide a kind of premature rupture of fetal membranes detection protection pad, including upper
Isolation permeable formation, the detection layers of middle layer and the absorbed layer of lower layer of layer, the detection layers contain pH indicators and creatinine inspection
Test agent, the pH indicators and creatinine detection reagent are fixed on absorbed layer spaced reciprocally by hydrophilic carrier respectively
On, the color range of the pH indicators is pH >=6.5, and the detection threshold value of the creatinine detection reagent is 5~40mg/dl.
The pH indicators and creatinine detection reagent upper layer have been covered each by transparent barrier film.
The color range of the pH indicators is pH6.5~pH7.0.
Spacing distance between the hydrophilic carrier and the hydrophilic carrier of creatinine detection reagent of the pH indicators exists
5mm or more.
The hydrophilic carrier of the pH indicators and the hydrophilic carrier of creatinine detection reagent are in absorbing layer surface side by side
It is spaced apart or concentric ring is spaced apart.
The pH indicators are phenol red reagent or bromthymol blue reagent.
The creatinine detection reagent is 3,5- dinitrobenzoic acid reagents, 3,3,5,5- tetramethyl benzidines reagent, creatinine
De- imines enzymatic reagent or creatinine amidohydrolase hydrolyze enzymatic reagent.
The isolation permeable formation uses medical micro porouse filter membrane.
It is equipped with leakproof film or release paper containing water suction macromolecule resin, the bottom surface of the absorbed layer in the absorbed layer,
The absorbed layer is equipped with fixation adhesive tape.
The protection pad detects underpants with the combined integrated disposable premature rupture of fetal membranes of formation of underpants.
Advantageous effect
First, specificity is high, using pH indicators and the bigeminy reagent of creatinine detection reagent synchronize be detected, effectively
Interference of the general urine to detection is excluded, the accuracy detected to amniotic fluid is improved, to reduce the probability of detection false positive；
Second, it is easy to operate, using the form of protection pad or disposable pants, sample sampling is avoided, is referred to without operation
Leading can detect and find premature rupture of fetal membranes in time.
Description of the drawings
Fig. 1 is the structural diagram of the present invention.
Specific implementation mode
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, people in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
A kind of premature rupture of fetal membranes as shown in Figure 1 detects protection pad, includes the detection layers 2 of the isolation permeable formation 1 on upper layer, middle layer
With the absorbed layer 3 of lower layer.
Permeable formation 1, which is isolated, uses medical micro porouse filter membrane, rapid drain that can either avoid the interference of some impurity, simultaneously
The stimulation of materials on skin can be reduced.
Detection layers 2 are detected amniotic fluid using bigeminy reagent, and bigeminy reagent is pH indicators and creatinine detection reagent.
PH indicators and creatinine detection reagent are fixed on by hydrophilic carrier on absorbed layer 3 spaced reciprocally respectively, and hydrophily carries
Body is spaced apart in 3 surface spacing side by side distribution of absorbed layer or concentric ring, and spacing distance between the two is in 5mm or more, parent
Aqueous carrier material is using cellulosic filter paper or flexible cotton material.Meanwhile in order to avoid detection reagent is to the possible thorn of skin
Swash, pH indicators and creatinine detection reagent upper layer have been covered each by layer of transparent isolation film, also reduce between two kinds of reagents
Interactional risk.
Ranging from pH >=6.5 the pH that pH indicator can obviously judge can obviously be developed the color in pH6.5 or more, in pH
Variation is not generated when less than 6.5, or has apparent color to distinguish, the color range of pH indicator is most between 6.5~7.0
It is good, including but not limited to phenol red reagent, bromthymol blue reagent etc..
The detection threshold value of creatinine (CRE) detection reagent is 5~40mg/dl, using dry type test paper (chemical method or enzyme process)
Detect the content of creatinine in body fluid.Chemical method includes 3,5- dinitrobenzoic acids method or 3,3,5,5- tetramethyl benzidines
(TMB) method；Enzyme process includes Creatinine deiminase method or creatinine amidohydrolase hydrolysis enzyme process.When the creatinine content in liquid is more than detection
Threshold value, reagent have apparent color change, can effectively distinguish urine and other liquid.
It is equipped with leakproof film or release paper containing water suction macromolecule resin, the bottom surface of absorbed layer 3 in absorbed layer 3, it can be right
The liquid of discharge is absorbed rapidly, effectively prevent revealing.Absorbed layer 3 is additionally provided with fixation adhesive tape, facilitates the fixation of protection pad.
Result judgement：When creatinine detection reagent has apparent color change, no matter whether pH indicator develops the color, under judgement
Body trickle is urine；Creatinine detection reagent color was substantially unchanged at that time, and pH discolorations are apparent, judge that lower body trickle is
Amniotic fluid.Using pH indicators and the bigeminy reagent of creatinine detection reagent synchronize be detected, specificity is high, effectively excludes general
Interference of the urine to detection improves the accuracy detected to amniotic fluid, to reduce the probability of detection false positive.
Claims (10)
1. a kind of premature rupture of fetal membranes detects protection pad, including the detection layers (2) of the isolation permeable formation (1) on upper layer, middle layer and lower layer
Absorbed layer (3), it is characterised in that：The detection layers (2) contain pH indicators and creatinine detection reagent, the pH indicators
It is fixed on spaced reciprocally by hydrophilic carrier on absorbed layer (3) respectively with creatinine detection reagent, the pH indicators
Color range is pH >=6.5, and the detection threshold value of the creatinine detection reagent is 5~40mg/dl.
2. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The pH indicators and creatinine
Detection reagent upper layer has been covered each by transparent barrier film.
3. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The colour developing of the pH indicators
Ranging from pH6.5~pH7.0.
4. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The pH indicators it is hydrophilic
Spacing distance between property carrier and the hydrophilic carrier of creatinine detection reagent is in 5mm or more.
5. a kind of premature rupture of fetal membranes according to claim 1 or 4 detects protection pad, it is characterised in that：The pH indicators
Hydrophilic carrier and the hydrophilic carrier of creatinine detection reagent are in the distribution of absorbed layer (3) surface spacing side by side or concentric central spacer
Distribution.
6. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The pH indicators are phenol red
Reagent or bromthymol blue reagent.
7. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The creatinine detection reagent is 3,
5- dinitrobenzoic acid reagents, 3,3,5,5- tetramethyl benzidines reagent, Creatinine deiminase reagent or creatinine amidohydrolase hydrolysis
Enzymatic reagent.
8. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The isolation permeable formation (1) is adopted
With medical micro porouse filter membrane.
9. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：Contain in the absorbed layer (3)
Absorb water macromolecule resin, and the bottom surface of the absorbed layer (3) is equipped with leakproof film or release paper, and the absorbed layer (3), which is equipped with, fixes
Adhesive tape.
10. a kind of premature rupture of fetal membranes according to claim 1 detects protection pad, it is characterised in that：The protection pad is unified with underpants group
Body forms disposable premature rupture of fetal membranes detection underpants.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810291342.1A CN108542596A (en) | 2018-04-03 | 2018-04-03 | Premature rupture of fetal membranes detects protection pad |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810291342.1A CN108542596A (en) | 2018-04-03 | 2018-04-03 | Premature rupture of fetal membranes detects protection pad |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108542596A true CN108542596A (en) | 2018-09-18 |
Family
ID=63513978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810291342.1A Pending CN108542596A (en) | 2018-04-03 | 2018-04-03 | Premature rupture of fetal membranes detects protection pad |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108542596A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030017605A1 (en) * | 2001-07-19 | 2003-01-23 | Common Sense Ltd. | Diagnostic pad |
| US20050131287A1 (en) * | 2003-12-16 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Detection of premature rupture of the amniotic membrane |
| WO2009050711A2 (en) * | 2007-10-18 | 2009-04-23 | Jacob Mullerad | A diagnostic device for identifying rupture of membrane during pregnancy |
| CN101813702A (en) * | 2010-04-01 | 2010-08-25 | 苏州市玮琪生物科技有限公司 | Tool and method for diagnosing premature rupture of membrane by continuous monitoring |
| CN201752403U (en) * | 2010-04-01 | 2011-03-02 | 苏州市玮琪生物科技有限公司 | Diagnostic tool for continuously monitoring premature rupture of membrane |
| CN204636718U (en) * | 2015-05-12 | 2015-09-16 | 辛琰琰 | Amniotic fluid detects health-care protection pad |
-
2018
- 2018-04-03 CN CN201810291342.1A patent/CN108542596A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030017605A1 (en) * | 2001-07-19 | 2003-01-23 | Common Sense Ltd. | Diagnostic pad |
| US20050131287A1 (en) * | 2003-12-16 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Detection of premature rupture of the amniotic membrane |
| WO2009050711A2 (en) * | 2007-10-18 | 2009-04-23 | Jacob Mullerad | A diagnostic device for identifying rupture of membrane during pregnancy |
| CN101813702A (en) * | 2010-04-01 | 2010-08-25 | 苏州市玮琪生物科技有限公司 | Tool and method for diagnosing premature rupture of membrane by continuous monitoring |
| CN201752403U (en) * | 2010-04-01 | 2011-03-02 | 苏州市玮琪生物科技有限公司 | Diagnostic tool for continuously monitoring premature rupture of membrane |
| CN204636718U (en) * | 2015-05-12 | 2015-09-16 | 辛琰琰 | Amniotic fluid detects health-care protection pad |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Esim et al. | Diagnosis of premature rupture of membranes by identification of β-HCG in vaginal washing fluid | |
| US9144520B2 (en) | Noninvasive detection of meconium in amniotic fluid | |
| Torbé | Maternal plasma procalcitonin concentrations in pregnancy complicated by preterm premature rupture of membranes | |
| Buyukbayrak et al. | Diagnostic power of the vaginal washing-fluid prolactin assay as an alternative method for the diagnosis of premature rupture of membranes | |
| Wells et al. | Maternal leucocyte zinc deficiency at start of third trimester as a predictor of fetal growth retardation. | |
| CN102053157A (en) | Test strip for fast detecting premature rupture of fetal membranes | |
| CN108542596A (en) | Premature rupture of fetal membranes detects protection pad | |
| CN101813702B (en) | Tool and method for diagnosing premature rupture of membrane by continuous monitoring | |
| CN201752403U (en) | Diagnostic tool for continuously monitoring premature rupture of membrane | |
| Duff et al. | Preterm prelabor rupture of membranes: clinical manifestations and diagnosis | |
| CN213465651U (en) | A disposable pants that is used for premature rupture of fetal membrane accurate protection pad that detects and is equipped with this protection pad | |
| Horger III et al. | Diagnostic use of amniotic fluid | |
| CN111643274A (en) | A protection pad for premature rupture of membrane accurate detection | |
| Azam et al. | PREMATURE RUPTURE OF MEMBRANES: DIAGNOSTIC ACCURACY OF β-hCG TEST IN VAGINAL WASHINGS TAKING AMNIOTIC FLUID POOLING AS GOLD STANDARD OF DIAGNOSING PRON | |
| Mills et al. | Use of the nitrazine yellow swab test in the diagnosis of ruptured membranes | |
| CN205006927U (en) | Premature rupture of fetal membranes detects sample pants | |
| CN216496070U (en) | Disposable self-testing pull-up pants for premature rupture of fetal membranes and vaginal bleeding during pregnancy | |
| US20070141655A1 (en) | Multi symptom medical test to diagnose causes of vaginitis | |
| CN201876456U (en) | Joint inspection kit for premature birth of pregnant woman and premature rupture of membrane | |
| CN221845265U (en) | Amniotic fluid early leakage detection protection pad | |
| US7763440B2 (en) | Diagnosis of pre-eclampsia | |
| CN210690415U (en) | Early broken monitoring protection pad of pregnant woman amniotic fluid | |
| US10677792B2 (en) | System for detection of an analyte in a fluid | |
| CN114019173B (en) | Marker for predicting non-syndromic cleft lip and palate and application thereof | |
| Townsend et al. | Sonographic identification of autosomal recessive polycystic kidney disease associated with increased maternal serum/amniotic fluid alphafetoprotein |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180918 |