CN108542225A - A kind of edible energy chopsticks - Google Patents
A kind of edible energy chopsticks Download PDFInfo
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- CN108542225A CN108542225A CN201810607584.7A CN201810607584A CN108542225A CN 108542225 A CN108542225 A CN 108542225A CN 201810607584 A CN201810607584 A CN 201810607584A CN 108542225 A CN108542225 A CN 108542225A
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- methanol
- bristle cudrania
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- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G21/00—Table-ware
- A47G21/10—Sugar tongs; Asparagus tongs; Other food tongs
- A47G21/103—Chop-sticks
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/06—Products with modified nutritive value, e.g. with modified starch content
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/40—Products characterised by the type, form or use
- A21D13/48—Products with an additional function other than for eating, e.g. toys or cutlery
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/36—Vegetable material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
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Abstract
One aspect of the present invention discloses a kind of edible energy chopsticks, and specific preparation process includes：Three-bristle cudrania leaf extract is prepared, dispensing mixing is poured into mold after mixing mashing, is molded through oven cooking cycle；On the other hand the application invention additionally discloses three-bristle cudrania leaf extract in preparing anti-depression drug, promoting nervous excitation drug.Section of the present invention has effects that energy stick, and energy conservation and environmental protection, significant effect, idea is novel, and multi-purpose content is of low cost, has no toxic side effect, suitable for large-scale promotion and production.
Description
Technical field
The present invention relates to effective ingredients in plant extraction field and food processing fields, and in particular to a kind of edible energy
The making of chopsticks and a kind of three-bristle cudrania leaf extract, preparation method and applications.
Background technology
In modern technologies, in the epoch of science and development, we have been absorbed in disease caused by not biodegradable material,
This has become the pith of our lives, such as plastic material.Plastics be exactly since occurring we live in can not or
A scarce part.Containing various carcinogenic, harmful and toxic chemical synthetic plastic is widely used in packaged food, drug, makeup
The products such as product and detergent.Increase suddenly with the use of these products, cancer, skin disease, cardiovascular and other diseases cases
Example is also more common in our society.
Chopsticks are China, Japan, the conventional cutlery of the Asian countries such as South Korea and Thailand.Guangzhou is the main production of chopsticks
Ground.Chopsticks are usually by wood, plastics, metal, bamboo and some jewelry such as ivory, and beautiful, silver and gold are made.In general, have two
Chopsticks-the throwaway chopsticks and reusable chopsticks of type.
The chopsticks damage to the environment of disposable type.It is annual to need to consume at least 30,000,000,000 pairs of chopsticks, it is one very severe
Environmental problem is directed not only to the accumulation of rubbish, and the whole world needs annual 3000000 trees of felling thus.Cause East Asia forest
One of the reason of covering is reduced is the increase in demand to these disposable chopsticks.It is counted according to China Green peace tissue,
The trees for needing 100 acres of felling daily to meet the needs of for throwaway chopsticks, that is, need 1,600 ten thousand to 2500 every year
Ten thousand trees.
The whole world has begun the exploitation to edible ware and cutter and has carried out various effort.One of them is edible
Use suction pipe.United States Patent (USP) 3493382 is disclosed with glycerin/propylene glycol, the liquid mixture production mould of Irish moss and tapioca
The method of edible product processed.Another United States Patent (USP) 5378418 discloses a kind of manufacture edible or is readily biodegradable
The method of material product, without the use of plasticizer or lubricant.WO/2005/021633 is related to being used to prepare the food based on starch
The composition of product or beverage container.In addition, WO/2008/090195 is disclosed by starch, plasticizer, protein, cross-linking enzyme and water
The biodegradable composition of composition.
WO2012098448A1 is related to the biodegradable eating utensils and its manufacturing method of various tablewares.It is existing still
There is technical limitation, so nobody commercially can successfully make edible chopstick.Unlike spoon and plate so hold
Easily, it needs especially to study various parameters, such as shape, hardness, solubility and stability.
Zhe Shu produces North China, East China, Central-South, each provinces and regions in southwest (north reaches Shaanxi, Hebei).It is widely distributed, it is sweet in flavor, it is mild-natured.Have
Blood-activating analgetic, expelling wind and removing dampness, relieving cough and reducing sputum effect also have certain research in its anti-tumor aspect in recent years.But without it
With the relevant report of energetic supersession.
Edible chopstick is similar with energy stick form, is easy to be accepted by the public, and the two brings out the best in each other, and is edible tableware
Innovation and breakthrough provide a new thinking.
Invention content
In view of the drawbacks described above of the prior art, the present invention provides a kind of preparing in drug for rush energetic supersession extract
Application.
To achieve the above object, the present invention provides a kind of edible energy chopsticks and three-bristle cudrania leaf extract to prepare antidepression
Application in disease drug, rush nervous excitation drug.
In the better embodiment of the present invention, on the one hand the present invention provides a kind of making sides of edible energy chopsticks
Method, production method include the following steps：
Step 1 prepares three-bristle cudrania leaf extract；
Certain proportion millet powder, wholewheat flour, cracker meal, wheat, water, butter, milk powder and sugar are uniformly mixed by step 2；
Step 3 is added the three-bristle cudrania leaf extract and is uniformly mixed；
Step 4 is added fragrance and is uniformly mixed, and mold is poured into after mashing；
Step 5, in an oven baking molding, wherein
Further, three-bristle cudrania leaf extract includes three-bristle cudrania leaf extract dry powder, three-bristle cudrania leaf extracting solution.
Further, millet powder in step 1, wholewheat flour, cracker meal, wheat ratio are 3:5:3:2
Further, drug extract and quality of food ratio are 1-2 in step 2:100
Further, oven temperature is 200-240 degree in step 3, and the time is 20 minutes.
Further, the preparation method of three-bristle cudrania leaf extract includes the following steps：
1), three-bristle cudrania leaf is cleaned, is dried in the shade and powder is made；
2) methanol solution, is added, ultrasound obtains crude extract；
3) crude extract in step 2, is concentrated into no alcohol taste, obtains concentration crude extract；
4), by the concentration crude extract macroporous resin adsorption in step 3；
5), press three column volume of water, 20% methanol, three column volume, 40% methanol, four column volume, 60% methanol, four column volume,
80% methanol, four column volume, 100% ethyl acetate, three cylinder sequentially eluting described in macroreticular resin, collect eluent；
6), the eluent that will be obtained by 40% ethyl alcohol third column volume to the 4th column volume and 60% the second column volume of ethyl alcohol
Cryogenic temperature freezing drying processing is carried out, the three-bristle cudrania leaf extract is obtained.
Further, in step 2) methanol solution a concentration of 40%-70%.
Further, the amount that methanol solution is added in step 2) is 1 gram of corresponding 8 ml methanol solution.
Further, methanol solution is divided into and being added twice in step 2), and carries out ultrasonic extraction respectively, and the time is 40-
60 minutes.
Further, it being concentrated using Rotary Evaporators (vacuum distillation) in step 3), thickening temperature is 40-60 DEG C,
Concentration crude extract is concentrated into 1st/20th of original volume.
Further, the macroreticular resin in step 4) is AB-8 resins.
Further, the dosage of macroreticular resin is isometric with the thick liquid of concentration in step 4).
Another aspect of the present invention provides the three-bristle cudrania leaf extract obtained according to above-mentioned preparation method, and its is preparing anti-suppression
Application in strongly fragrant disease drug, rush nervous excitation drug.
It is extract obtained to have significant increase energy generation the present invention provides a kind of mode of three-bristle cudrania tree active ingredient essence extraction
The effect of thanking.Any poisonous and harmful substance is not added in experimentation, and the present invention is used for the first time by the similar edible chopsticks of shape
The concept that son and energy stick are combined.Present invention process is simple, cheap, widely used, novel concept, is suitble to extensive work
Skill produces.
The technique effect of the design of the present invention, concrete structure and generation is described further below with reference to attached drawing, with
It is fully understood from the purpose of the present invention, feature and effect.
Description of the drawings
Fig. 1 is the edible energy chopsticks pictorial diagram of the preferred embodiment of the present invention；
Fig. 2 is the three-bristle cudrania leaf extract extraction flow chart of the preferred embodiment of the present invention；
Fig. 3 is that the CCK-8 of the preferred embodiment of the present invention measures cell survival rate testing result comparison diagram；
Fig. 4 is that the atp/bca of the preferred embodiment of the present invention measures 6h comparative result figures；
Fig. 5 is that the atp/bca of the preferred embodiment of the present invention measures 12h comparative result figures；
Fig. 6 is the mouse forced swimming environment map of the preferred embodiment of the present invention；
Fig. 7 is the mouse forced swimming comparative result figure of the preferred embodiment of the present invention；
Fig. 8 is the HPLC result figures of the eluent 20-2 of the preferred embodiment of the present invention；
Fig. 9 is the HPLC result figures of the eluent 20-3 of the preferred embodiment of the present invention；
Figure 10 is the HPLC result figures of the eluent 20-4 of the preferred embodiment of the present invention；
Figure 11 is the mass spectral results figure of the effective drug of most probable of the preferred embodiment of the present invention；
Figure 12 is the mass spectrometry results figure of the effective drug of most probable of the preferred embodiment of the present invention；
Wherein, C is culture solution control group；1, eluent：20% methanol -1；2, eluent：20% methanol -2；3, it elutes
Liquid：20% methanol -3；4, eluent：20% methanol -4；5, eluent：20% methanol -5；6, eluent：20% methanol -6；h1、
Eluent：Water -1；H2, eluent：Water -3；H3, eluent：Water -5；7, three-bristle cudrania tree flavone A；8, methoxyl group Luteolin；9, different Huang
Ketone C；10、MacuraxanthoneB；11、ToxyloxanthoneC.
Specific implementation mode
Embodiment 1
1, three-bristle cudrania leaf extract is prepared
The extraction flow chart of three-bristle cudrania leaf extract is as shown in Figure 2, three-bristle cudrania foliage samples is cleaned, dries in the shade and is ground powder is made
End obtains 500g powder；Configure 50% methanol 4L；Said extracted liquid is added in two portions, 2L milliliters are added for the first time, adds for the second time
Enter 2L milliliters, is extracted about 1 hour with ultrasonic (300w, SB5200D) after being added every time, obtain crude extract；Crude extract is passed through into rotation
Turn to be concentrated by evaporation to no alcohol taste (about 200 milliliters), obtains concentration crude extract；Weighing 200 grams of AB-8 macroreticular resins, (column volume is about
200 milliliters), the concentration crude extract obtained in step 3 is crossed into column, is adsorbed about 2 hours；By three column volume of water, 20% methanol, four column
Volume, 40% methanol, four column volume, three cylinder of 60% methanol, three column volume, 80% methanol, four column volume and 100% ethyl acetate
The above-mentioned macroreticular resin of long-pending sequentially eluting, obtains the chromatographic solution of different component；It is collected with 100 milliliters/bottle, and uses rotary evaporation
Instrument be evaporated under reduced pressure to no alcohol taste (be concentrated into 20ml per 100ml, 80% methanol and acetic acid ethyl acetate extract then low temperature drying to powder
End)；As unit of 100ml chromatographic solutions, water -1, water -2, water -3, water -4, water -5, water -6,20% methanol -1,20% are then obtained
Methanol -2,20% methanol -3,20% methanol -4,20% methanol -5,20% methanol -6,20% methanol -7,20% methanol -8,
40% methanol-Isosorbide-5-Nitrae, 0% methanol -2,40% methanol -3,40% methanol -4,40% methanol -5,40% methanol -6,40% methanol -7,
40% methanol -8,60% methanol -1,60% methanol -2,60% methanol -3,60% methanol -4,60% methanol -5,60% methanol -6,
60% methanol -7,60% methanol -8,80% methanol -1,80% methanol -2,80% methanol -3,80% methanol -4,80% methanol -5,
80% methanol -6,80% methanol -7,80% ethyl alcohol -8, ethyl acetate 100%-1, ethyl acetate 100%-2, ethyl acetate
100%-3, ethyl acetate 100%-4, ethyl acetate 100%-5, ethyl acetate 100%-6 totally 44 parts of eluents.Through cell reality
It is high efficiency extraction object to test 40% methanol -5,40% methanol -7,60% methanol -3 of screening, this extract is used in combination to continue to test.
2, CCK-8 measures cell survival rate
CCK-8 (Cell Counting Kit-8) reagent can be used for easy and accurate cell Proliferation and oxicity analysis,
Basic principle is：Contain WST-8 (chemical names in the reagent：2- (2- methoxyl group -4- nitrobenzophenones) -3- (4- nitrobenzophenones) -5-
(2,4- disulfonic acid benzene) -2H- tetrazolium monosodium salts), its work in electron carrier 1- methoxyl group -5- toluphenazine dimethyl suflfates
It is reduced to the yellow first a ceremonial jade-ladle, used in libation product with high water soluble, the quantity of the first a ceremonial jade-ladle, used in libation object of generation and work with the lower dehydrogenase by cell
The quantity of cell is directly proportional, therefore can directly carry out cell Proliferation and oxicity analysis using this characteristic.It is configured to contain with DMEM
Horse serum 9%, cow's serum 6%, dual anti-0.5% culture solution, with 1.5 ten thousand, every hole pc12 cell inoculations in 96 orifice plates,
The three-bristle cudrania leaf extract of above-mentioned 44 samples, three-bristle cudrania leaf extract and culture solution ratio are added after being incubated 24 hours in cell incubator
Example is 1:9,1:19,1:39；Cell survival rate is detected after 72 hours.Testing result shows three-bristle cudrania leaf extract small toxicity, wherein
Extracting section liquid is not only non-toxic, and has the function of certain promotion cell growth, and (c is indicated only experimental result as shown in Figure 3
Add the control group of culture solution).
3, atp/bca is measured
Cell intracellular atp is measured with Roche atp kits, with reaction energy metabolic condition.Measuring bca obtains born of the same parents simultaneously
Interior total protein value, the ratio reaction true atp situations of change of intracellular are measured to obtain drug pair for 24 hours respectively in 6h, 12h
The timetable that energetic supersession promotes.Speculate drug effective time, 6h, 12h test results such as Fig. 4, shown in Fig. 5.
4, mouse swimming test
C57 systems mouse is selected to carry out mouse swimming test, " chopsticks " ingredient that feeding pulverizes.Mouse is carried out after two hours
Swimming test, experiment photo are as shown in Figure 6.Compared with the control group, tetra- groups of mouse of 20-2,20-3,20-4 adhere to the time in water
Have and extend by a relatively large margin, wherein 20-4 (300mg/kg) effect is the most notable, and effect is similar with Prozac.Experimental situation is such as
Shown in Fig. 6, experimental result is as shown in fig. 7, experiments have shown that edible energy chopsticks can effectively enhance human body energy metabolism really.
5, mouse safety experiment
Although experimentation is not added with any harmful toxic matter, further to prove extract safety, we are in feeding
24 hours eyeball blood taking methods acquire mouse bloods and carry out hepatic and renal function blood routine detection in hospital after " chopsticks " ingredient pulverized,
As a result show not damaged, data are as shown in table 1.
The mouse hepatic and renal function blood routine detection data after the test of table 1
| Parameter | Unit | Reference value | 150mg/kg | 300mg/kg |
| Aspartate aminotransferase | U/L | 74.37±2.98X | 58.17±5.39X | 49.23±2.018X |
| Alanine aminotransferase | U/L | 57.36±2.23X | 45.39±2.17Y | 47.37±3.15Y |
| Alkaline phosphatase | U/L | 115.21±14.03X | 133±13.3X | 137.7±17.8X |
| Lactic dehydrogenase | U/L | 459±39.02Y | 379.02±24.04X | 363.03±32.3X |
| Albumin | g/dL | 3.57±0.25X | 3.17±0.08X | 3.84±0.23X |
| Total Amount of Bile | mg/dL | 51.67±5.08X | 49.69±3.51X | 48.57±4.35X |
| Total protein | g/dL | 5.23±0.23X | 6.18±0.21X | 5.98±0.23X |
| Blood urea nitrogen | mg/dL | 27.49±2.54X | 23.47±2.17Y | 21.47±2.19 |
| Creatinine | mg/dL | 0.49±0.01X | 0.47±0.03X | 0.41±0.23X |
| Uric acid | mg/dL | 1.98±0.17X | 1.74±0.16X | 1.82±0.22Y |
| Total cholesterol | mg/dL | 115.13±4.95X | 125.04±7.3Y | 129±6.13X |
| Triacylglycerol | mg/dL | 79.43±6.01X | 73.81±3.71 | 67.14±6.14Y |
6, HPLC experiments and MS experiments
High performance liquid chromatography is a chromatographic important branch,, will using high pressure transfusion system using liquid as mobile phase
The mobile phases such as mixed solvent, the buffer solution of single solvent or different proportion with opposed polarity are pumped into the chromatography equipped with stationary phase
Column is detected after each ingredient is detached in column into detector, to realize the analysis to sample.It is eluent below
The HPLC of 20-2, eluent 20-3, eluent 20-4 scheme, respectively Fig. 8, Fig. 9, Figure 10, three extractive HPLC atlas analysis
The display effective drug of most probable is 449.2058 (449.2017), and mass spectral results are as shown in figure 11.
As shown in figure 12, according to HPLC-MS interpretations of result, we determined that it is following it is several be present in it is effective in extract
Ingredient includes：CudraflavoneA (three-bristle cudrania tree flavone A), Chrysoeriol (chrysoeriol), IsoflavoneC is (different
Flavones C), MacuraxanthoneB, ToxyloxanthoneC etc..
Embodiment 2
A kind of making of edible energy chopsticks
Select millet powder 30g, wholewheat flour 50g, cracker meal 30g, wheat 20g and suitable quantity of water, 5mg milk powder, 5mg white granulated sugars
With active drug extract 2g (being respectively 20-2,20-3,20-4).Pour into mold and 20 minutes in 220 degree of baking ovens.So
After obtain edible energy chopsticks, obtained edible energy chopsticks are screened, carries out disinfection, pack to qualified products, to not
Qualified products crush processing, and wherein finished product is as shown in Figure 1.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is without wound
The property made labour, which according to the present invention can conceive, makes many modifications and variations.Therefore, all technician in the art
Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Scheme, all should be in the protection domain being defined in the patent claims.
Claims (10)
1. a kind of edible energy chopsticks, which is characterized in that production method includes the following steps：
Step 1 prepares three-bristle cudrania leaf extract；
Certain proportion millet powder, wholewheat flour, cracker meal, wheat, water, butter, milk powder and sugar are uniformly mixed by step 2；
Step 3 is added the three-bristle cudrania leaf extract and is uniformly mixed；
Step 4 is added fragrance and is uniformly mixed, and mold is poured into after mashing；
Step 5, in an oven baking molding, wherein
The three-bristle cudrania leaf extract includes three-bristle cudrania leaf extract dry powder, three-bristle cudrania leaf extracting solution.
2. a kind of edible energy chopsticks according to claim 1, which is characterized in that three-bristle cudrania leaf extract described in step 1
Preparation method include the following steps：
1), three-bristle cudrania leaf is cleaned, is dried in the shade and powder is made；
2) methanol solution, is added, ultrasound obtains crude extract；
3) crude extract in step 2, is concentrated into no alcohol taste, obtains concentration crude extract；
4), by the concentration crude extract macroporous resin adsorption in step 3；
5), according to three column volume of water, 20% methanol, three column volume, 40% methanol, four column volume, 60% methanol, four column volume, 80%
Four column volume of methanol, 100% ethyl acetate, three cylinder sequentially eluting described in macroreticular resin, collect eluent；
6), the eluent that will be obtained by 40% ethyl alcohol third column volume to the 4th column volume and 60% the second column volume of ethyl alcohol
Cryogenic temperature freezing drying processing is carried out, the three-bristle cudrania leaf extract is obtained.
3. edible energy chopsticks according to claim 1, which is characterized in that millet powder described in step 1, wholewheat flour,
Cracker meal, wheat ratio are 3:5:3:2.
4. a kind of edible energy chopsticks according to claim 1, which is characterized in that drug extract described in step 2 with
Quality of food ratio is 1-2:100.
5. preparation method according to claim 2, which is characterized in that a concentration of 40%- of methanol solution described in step 2
70%.
6. preparation method according to claim 2, which is characterized in that the amount that methanol solution described in step 2 is added is 1 gram
Dry three-bristle cudrania leaf corresponds to 8 ml methanol solution.
7. preparation method according to claim 2, which is characterized in that it is concentrated using Rotary Evaporators in step 3, it is dense
Contracting temperature is 40-60 DEG C, and the concentration crude extract is concentrated into original volume 1/20th.
8. preparation method according to claim 2, which is characterized in that the dosage of macroreticular resin described in step 4 for institute
It is isometric to state the thick liquid of concentration.
9. the three-bristle cudrania leaf extract that the preparation method according to any one of claim 2-8 obtains.
10. three-bristle cudrania leaf extract according to claim 9 answering in preparing anti-depression drug, promoting nervous excitation drug
With.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156740A (en) * | 2007-11-23 | 2008-04-09 | 范义涵 | An edible chopstick |
| CN102293566A (en) * | 2011-08-19 | 2011-12-28 | 罗来康 | Edible chopsticks |
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