CN108514643A - A kind of small pulmonary nodules carry out operation consent color and tactile markings method - Google Patents
A kind of small pulmonary nodules carry out operation consent color and tactile markings method Download PDFInfo
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- CN108514643A CN108514643A CN201810346588.4A CN201810346588A CN108514643A CN 108514643 A CN108514643 A CN 108514643A CN 201810346588 A CN201810346588 A CN 201810346588A CN 108514643 A CN108514643 A CN 108514643A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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Abstract
The invention discloses a kind of small pulmonary nodules to carry out operation consent color and tactile markings method, it is characterized in that：The labeling method includes step in detail below：It prepares methylene blue+fibrin ferment+calcium chloride solution and prepares two kinds of solution of fibrinogen, lung puncture needle is connected by three-way pipe through two different syringes respectively, upper two kinds of solution is synchronized and is injected into lung micronodule affected area, the gel tubercle of blue is formed in affected area.The gel tubercle of this blue is visual, is also accessible, and surgical doctor can be accurately positioned small pulmonary artery by vision and tactile, cut off.Required drug is easy to get and cheap, and sustainable 2 days of effect or more, is conducive to the flexible selection of opportunity of operation after label.
Description
Technical field
The present invention relates to the labeling method technical field of lung's minimal disease operative treatment, specially a kind of lung is small
Tubercle carries out operation consent color and tactile markings method.
Background technology
Lung cancer be in the world at present most common malignant tumour, incidence and lethality are in list in all malignant tumours
It is first.It is the early stage lung mainly showed with diameter 1cm small pulmonary nodules below recently as the continuous development of detection methods
The discovery rate of cancer significantly improves so that more has patients with lung cancer that can obtain Operation in early stage and is therefore able to long-term surviving.
Video-assistant thorascope Minimally Invasive Surgery, which is that this early stage of lung cancer for showing as micronodule is most effective and preferred, to be controlled
Treatment method can make patient's long-term surviving.Successful one of key of performing the operation is preoperative accurate positionin to ensure accurately, completely
Removal of lesions.Show as lesser tubercle at present（1cm or so）The preoperative standard of early stage lung localization method mainly such as
Hookwire metal hook lines, but Hookwire metal hook lines are that a kind of medical disposable material needs certain expense and performing the operation
It is accurately positioned in journey since hook line displacement easily occurs in the collapse of lung and then influences lesion.Also someone is same using the injection of lesion unit
The plain tracer in position, barium sulfate, lipiodol etc. are marked, but have larger defect.Such as isotope labelling is used not only to have same position
Element pollutes and is not easy to be accurately positioned；And barium sulfate, labeled in lipiodol is used then to need Cooperation in operation that could determine using X-ray examination
Position, it is both inconvenient or make operator is unnecessary to receive X-ray exposure, in addition, above two contrast agent is also easy to disperse, cause
Positioning is inaccurate.
Invention content
The purpose of the present invention is to provide a kind of small pulmonary nodules to carry out operation consent color and tactile markings method, with solution
Certainly the problems mentioned above in the background art.
To achieve the above object, the present invention provides the following technical solutions：A kind of small pulmonary nodules progress operation consent color
And tactile markings method, the labeling method include step in detail below：
Step【1】Carry out the preparation of A liquid：
（1）Anhydrous calcium chloride is dissolved using 0.9% sodium chloride injection of room temperature, the calcium chloride for being configured to concentration 145mmol/L is molten
Liquid is spare；
（2）Fibrin ferment is dissolved using 0.9% sodium chloride injection of room temperature, it is spare to be configured to concentration 100IU/ml thrombin solutions；
（3）It is spare to take methylenum careuleum finished product stoste 2ml；
A concentration of 100IU/ml thrombin solutions of calcium chloride solution, 1ml and 0.4ml that a concentration of 145mmol/L of 0.2ml will be taken
Methylenum careuleum finished product stoste is uniformly mixed, and it is spare to be configured to A liquid.
Step【2】Carry out the preparation of B liquid：
Using 37 DEG C of 0.9% sodium chloride injection, solution fibrin is former in 37 DEG C of thermostatic water baths, is configured to 10mg/ml fibres
Fibrillarin original solution is spare；
Step【3】To the label of small pulmonary nodules：
（1）Small pulmonary nodules are punctured using 22G fine needles under CT guiding, needle point is made accurately to reach lesion；
（2）Needle core is taken out, three-way pipe is connected；
（3）It is spare that A liquid 0.1ml is extracted with syringe a；It is spare that B liquid 0.5ml is extracted with syringe b；
（4）Syringe a and syringe b are respectively connected to the distinct interface of three-way pipe；
（5）Inject A liquid in advance；
（6）And then B liquid is injected；
（7）Exit puncture needle.
Two kinds of solution are mixed to form the gel tubercle of blue in affected area, the gel tubercle of this blue be it is visual, can
It touches, surgical doctor can be accurately positioned small pulmonary artery by vision and tactile, cut off.
Compared with prior art, the beneficial effects of the invention are as follows：This method can form the gel tubercle of blue in affected area,
The gel tubercle of this blue is visual, it is accessible to be also, surgical doctor can by vision and tactile to small pulmonary artery into
Row is accurately positioned, cuts off, and this method simplicity, safety, economy, required drug is country【It is accurate】Font size, be easy to get and
Cheap, sustainable 2 days of effect or more, is conducive to the flexible selection of opportunity of operation after label.
Description of the drawings
Fig. 1 is that solution A is successively injected target site by the present invention from the different syringes of solution B, and forming blue can touch
And gel marker schematic diagram.
Fig. 2 is that the present invention uses methylenum careuleum fibrin gel solubility curve schematic diagram.
Fig. 3 is methylenum careuleum fibrin gel course of dissolution table of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of technical solution：
Embodiment 1：
A kind of small pulmonary nodules carry out operation consent color and tactile markings method, it is characterized in that：The labeling method includes following
Specific steps：
Step【1】Carry out the preparation of A liquid：
（1）Anhydrous calcium chloride is dissolved using 0.9% sodium chloride injection of room temperature, the calcium chloride for being configured to concentration 145mmol/L is molten
Liquid is spare；
（2）Fibrin ferment is dissolved using 0.9% sodium chloride injection of room temperature, it is spare to be configured to concentration 100IU/ml thrombin solutions；
（3）It is spare to take methylenum careuleum finished product stoste 2ml；
A concentration of 100IU/ml thrombin solutions of calcium chloride solution, 1ml and 0.4ml that a concentration of 145mmol/L of 0.2ml will be taken
Methylenum careuleum finished product stoste is uniformly mixed, and it is spare to be configured to A liquid.
Step【2】Carry out the preparation of B liquid：
Using 37 DEG C of 0.9% sodium chloride injection, solution fibrin is former in 37 DEG C of thermostatic water baths, is configured to 10mg/ml fibres
Fibrillarin original solution is spare；
Step【3】To the label of small pulmonary nodules：
（1）Small pulmonary nodules are punctured using 22G fine needles under CT guiding, needle point is made accurately to reach lesion；
（2）Needle core is taken out, three-way pipe is connected；
（3）It is spare that A liquid 0.1ml is extracted with syringe a；It is spare that B liquid 0.5ml is extracted with syringe b；
（4）Syringe a and syringe b are respectively connected to the distinct interface of three-way pipe；
（5）Inject A liquid in advance；
（6）And then B liquid is injected；
（7）Exit puncture needle.
Two kinds of solution are mixed to form the gel tubercle of blue in affected area；The gel tubercle of this blue be it is visual, can
It touches, surgical doctor can be accurately positioned small pulmonary artery by vision and tactile, cut.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (1)
1. a kind of carrying out operation consent color and tactile markings method to small pulmonary nodules, it is characterized in that：The labeling method includes
Step in detail below：
Step【1】Carry out the preparation of A liquid：
（1）Anhydrous calcium chloride is dissolved using 0.9% sodium chloride injection of room temperature, the calcium chloride for being configured to concentration 145mmol/L is molten
Liquid is spare；
（2）Fibrin ferment is dissolved using 0.9% sodium chloride injection of room temperature, it is spare to be configured to concentration 100IU/ml thrombin solutions；
（3）It is spare to take methylenum careuleum finished product stoste 2ml；
A concentration of 100IU/ml thrombin solutions of calcium chloride solution, 1ml and 0.4ml that a concentration of 145mmol/L of 0.2ml will be taken
Methylenum careuleum finished product stoste is uniformly mixed, and it is spare to be configured to A liquid；
Step【2】Carry out the preparation of B liquid：
Using 37 DEG C of 0.9% sodium chloride injection, solution fibrin is former in 37 DEG C of thermostatic water baths, is configured to 10mg/ml fibres
Fibrillarin original solution is spare；
Step【3】To the label of small pulmonary nodules：
（1）Small pulmonary nodules are punctured using 22G fine needles under CT guiding, needle point is made accurately to reach lesion；
（2）Needle core is taken out, three-way pipe is connected；
（3）It is spare that A liquid 0.1ml is extracted with syringe a；It is spare that B liquid 0.5ml is extracted with syringe b；
（4）Syringe a and syringe b are respectively connected to the distinct interface of three-way pipe；
（5）Inject A liquid in advance；
（6）And then B liquid is injected；
（7）Exit puncture needle；
Step【4】For two kinds of solution in the gel tubercle for being mixed to form blue in affected area, the gel tubercle of this blue is visual
, it is accessible, surgical doctor can be accurately positioned small pulmonary artery by vision and tactile, be cut off.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810346588.4A CN108514643A (en) | 2018-04-18 | 2018-04-18 | A kind of small pulmonary nodules carry out operation consent color and tactile markings method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810346588.4A CN108514643A (en) | 2018-04-18 | 2018-04-18 | A kind of small pulmonary nodules carry out operation consent color and tactile markings method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440622A (en) * | 2020-03-26 | 2021-09-28 | 西安交通大学医学院第一附属医院 | Magnetic gel for preoperative positioning of pulmonary nodules, preparation process and application system thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101052426A (en) * | 2004-10-29 | 2007-10-10 | 脊柱修复公司 | Injection of fibrin sealant including an anesthetic in spinal applications |
-
2018
- 2018-04-18 CN CN201810346588.4A patent/CN108514643A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101052426A (en) * | 2004-10-29 | 2007-10-10 | 脊柱修复公司 | Injection of fibrin sealant including an anesthetic in spinal applications |
Non-Patent Citations (2)
| Title |
|---|
| KONGJIA LUO ET AL.: "Localization of peripheral pulmonary lesions to aid surgical resection: a novel approach for electromagnetic navigation bronchoscopic dye marking", 《EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY》 * |
| 周君君等: "肺小结节术前CT定位下硬化剂定位的临床应用", 《中华肿瘤防治杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440622A (en) * | 2020-03-26 | 2021-09-28 | 西安交通大学医学院第一附属医院 | Magnetic gel for preoperative positioning of pulmonary nodules, preparation process and application system thereof |
| CN113440622B (en) * | 2020-03-26 | 2023-05-26 | 西安交通大学医学院第一附属医院 | Magnetic gel for pre-operation positioning of pulmonary nodules, preparation process and application system thereof |
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Application publication date: 20180911 |
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