CN108498903A - Medication reconstitution device - Google Patents
Medication reconstitution device Download PDFInfo
- Publication number
- CN108498903A CN108498903A CN201810197538.4A CN201810197538A CN108498903A CN 108498903 A CN108498903 A CN 108498903A CN 201810197538 A CN201810197538 A CN 201810197538A CN 108498903 A CN108498903 A CN 108498903A
- Authority
- CN
- China
- Prior art keywords
- plug member
- hybrid channel
- plug
- diluent
- cartridge part
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
Abstract
It is a kind of to can be used for being lyophilized, store and the container of reconstituted drugs, only include two components, a component is plug member, has the flow path for terminating at distal bottom outlet, and the hybrid channel with proximate distal ends, to store powder medicaments and generate gradient concentration when restoring.Another component is cartridge unit, and cartridge unit has the internal cavity for housing the hybrid channel.
Description
Technical field
The present invention relates to drug recoveries, more particularly, to compact with the drug of Fast Restoration drying kinetics for storing
Device.
Background technology
Due to the continuous progress of gene and cell engineering, it is known that in vivo play the protein of pharmacological action
Can mass production be used for pharmaceutical applications.However, it is that processing is this most to have one of challenge task in the research and development of protein pharmaceuticals
Protein（Especially with water dosage forms）Intrinsic physics and chemical instability.Functionally, injectable drug is steady
It is qualitative to may be defined as its holding chemistry, sterile, the ability of toxicology and treatment specification within the 90% of its original effect.Wherein
The pre-filled syringe that these protein pharmaceuticals and other drugs are stored in the form of water provides many effects.However,
The drug rapid deterioration of many injectables, and its solution loses their effect.
Because of the unstability with aqua amount morphologic correlation, it is usually preferred to which power formulations are with the expectation shelf-life for product
Realize enough stability.Know in the industry of pharmacy and biotechnology and has put into practice the various technologies for preparing dry powder.It is this
Technology includes desivac（Freeze-drying）, atomizing freeze drying, agllutination be brilliant, vacuum drying and foam-drying.Desivac（Freezing is dry
It is dry）Typically it is used for preparing the dry powder containing protein（Lyophilized products）Preferred method.The various methods of freeze-drying are for this field
Those skilled in the art be well known.Freeze-drier and processing use vacuum, the vacuum to be converted into the liquid portion of drug solid
Body, and by sub-atmospheric pressure to form steam.Steam is extracted out from cryodesiccation chamber by steam channel, and is discharged to outside freeze-drier
Region.Liquid medicine is reduced into dry powder or particle shape by frozen dried.Before clinical injection, by using dilute
Release solvent reconstruct dried soluble drug, it is therefore desirable to provide medication reconstitution device to complete above-mentioned liquid mixed process.
In the prior art, patent CN103582473B（Document 1）A kind of medication reconstitution device is disclosed, with plug part
Part and cartridge unit, and circumferential 360 degree of continuous diluent distributing troughs.The diluent distributing trough is entirely around the plug side
Portion, and at least one of inner surface for being formed in the plug member side periphery and cartridge part, the diluent point
Slot allocation is positioned to connect with the plug outlet port；In addition, also having diluent interconnection groove, it is longitudinally formed at the cylinder
In the inner surface of the inner wall of component, the length of the diluent interconnection groove is chosen to and the diluent distributing trough and and medicine
The input terminal of liquid hybrid channel connects, wherein the hybrid channel provides the diluent interconnection groove and the outer jet connects
Connect the indirect flow path between device port；After reaching plug member insertion cartridge unit, without considering plug member rotation
Turn in the case of being orientated, it is ensured that diluent enters liquid hybrid channel from the input terminal of liquid hybrid channel always.In addition, document
The integrated component that hybrid channel is formed as to the plug member is given in 1 so that the plug member and the mixing are logical
The case where road is single component, the technical solution equally use the design method of diluent distributing trough+diluent interconnection groove.
However, one of the most important aspect of distribution of freeze-drying prods is the reliability of container.Another importance is exactly to dividing
Control with cost.The container for being used to be lyophilized drug must have low cost, it should reliably use.Additionally, container is answered
This is used easily and intuitively.Container with a large amount of components is more unreliable, and manufactures more expensive.
Such as the medication reconstitution device provided in document 1, due to the setting of " diluent distributing trough " and " diluent interconnection groove ",
It increases drug and restores dress manufacture difficulty of processing and complexity, increase manufacturing cost.In addition, in order to ensure diluent passes through
" diluent interconnection groove " and the input terminal for flowing into hybrid channel, it is desirable that " diluent interconnection groove " with can be by its closed side（It is false
If " diluent interconnection groove " is set to cartridge unit inner wall, then by the side of plug member by its closure of openings）Between matching
Required precision is very high, can cause to flow out " diluent interconnection groove " outside diluent if gap between the two is excessive, if between the two
Assembly resistance and the difficulty between plug member and cartridge unit are then increased against tension.
Invention content
For problems of the prior art, the present invention is provided one kind and being arranged to the diluent when being contacted with concentration gradient
The compact medicament freeze-drying and recovery receptacle of dry drug are rapidly restored, including：Plug member 1, with proximal end 2, distal end 3
And the side 4 being arranged between the proximal end 2 and the distal end 3, the plug member 1 have external dilution agent connector port
5, and with from the diluent connector port 5 to the inside dilution of the plug outlet port 6 of bottom at the distal end 3
Agent flow path 7；Cartridge unit 8 coordinates with the plug member 1, and there is cartridge part inner wall, the inner wall to have interior table
Face 9, forms internal cavity in the inner surface 9, and cartridge part also has the distal end with outer jet connector port 10；
Conduit wall 11, the conduit wall 11 form hybrid channel, and the conduit wall 11 is formed in the distal end of the plug member 1 so that
There is the top being closed and open bottom, the height and length that the conduit wall 11 has to be chosen to for the hybrid channel 12
The drug powder of whole amount is completely included in the hybrid channel 12, while also retaining open sky in the hybrid channel 12
Between, the hybrid channel 12 has input terminal 13 and output end 14, when the plug member 1 and cartridge part 8 are assembled in one
When rising, the output end 14 is connected to the outer jet connector port 10；When the plug member 1 and cartridge part 8
When fitting together, the bottom of the hybrid channel 12 and conduit wall 11 can be held by the internal cavity of cartridge part 8
It sets, drug powder can be pushed into the hybrid channel by the bottom 17 of the internal cavity, and contacted and closed the hybrid channel
12 bottom so that provided to the drug powder only by the input terminal 13 and output end 14 of the hybrid channel 12
It is close；And wherein, diluent is forced to make described in the diluent flowing process by the diluent connector port
Plug member 1, by the internal diluent flow path 7, the plug outlet port 6, flow into the hybrid channel 12
The input terminal 13, and by the space in the hybrid channel 12 the drug powder is restored to be contacted with the drug powder
End forms the reconstituted solution with drug concentration gradient to flow out the outer jet connector port 10 with conveying solution,
The subsequent flowing of reconstituted solution described in the concentration ratio for the drug that the initial flow of the reconstituted solution has wants high.
Further, the conduit wall 11 is formed integrally as a part for the plug member 1 so that the plug part
Part 1 and the hybrid channel 12 are single components, and wherein, and the bottom 17 of the internal cavity of cartridge part 8, which has, to be closed
Close surface so that when being assembled with the plug member 1, form the closing bottom of the hybrid channel 12.
Further, there is the proximal end 2, distal end 3, side 4, external dilution agent connector port 5, the plug outlet
It is whole that the plug member 1 and the conduit wall 11 of port 6 and the hybrid channel 12 are all formed as single first together
Part；And the inner wall, the internal cavity and the outer jet connector port 10 of cartridge part 8 are all formed as together
Single second single piece；Wherein, the recovery receptacle device is only made of two components.
Further, the plug member 1 and cartridge part 8 are adjacent to that in the proximal end of the plug member 1
This cooperation；Sealing ring 15 is provided between the plug member 1 and cartridge part 8 so that the two is sealed in one after being fitted to each other
It rises.
Further, the plug member 1 and cartridge part 8 are adjacent to that in the proximal end of the plug member 1
This cooperation；It is adjacent to the place that is fitted to each other described, welding material is formed in the plug member 1 and cartridge part 8 extremely
In few one so that suitable energy is applied to the welding material and the plug and cartridge part are sealed.
Further, cartridge part 8 includes the first clamping close device, and the plug member 1 includes that the second engaging fills
It sets, second clamping close device is configured to coordinate with first clamping close device so that when the plug member 1 and cartridge
When part 8 is combined together, first and second clamping close device is fitted to each other, and resists the plug member 1 and institute securely
State the dismounting of cartridge unit 8.
Further, the recovery receptacle device, is additionally operable to dry liquid drug；Wherein, the plug member 1 is selected
Outer shape so that before assembling the plug member 1 and cartridge part 8, the plug member 1 may be mounted at branch
In support arrangement, and the hybrid channel 12 be in open channels construction in, and the open section of the hybrid channel 12 up towards
To liquid medicine stays in unlimited cavity for processing to be dried；And wherein, the internal cavity of cartridge part 8
Bottom 17 has flat surface so that the liquid medicine be dried to drug powder and the plug member 1 with
After cartridge part 8 coordinates, the drug powder is pushed completely into the hybrid channel 12 by the flat surfaces, and is closed
The bottom of the hybrid channel 12；Wherein, the recovery receptacle device is used for dry liquid drug, stores dry drug and answer
The dry drug of original.
Further, it is provided with control liquid one-way flowing device at the plug outlet port 6, liquid is made uniaxially to pass through
The internal diluent flow path 7, the plug outlet port 6 are crossed, the input terminal 13 of the hybrid channel 12 is flowed into.
Further, the control liquid one-way flowing device is liquid non-return valve.
The invention has the beneficial effects that：
（1）The present invention outlet port of plug member can be arranged in plug member distal bottom, and neighbouring hybrid channel inputs
At end.And then in the case of can reaching without considering that plug member is rotationally oriented, it is ensured that diluent is always from hybrid channel
Input terminal enters hybrid channel.
（2）The outlet port of plug member of the present invention is arranged at the hybrid channel arrival end of plug member distal bottom,
And avoid using the setting of the construction and devices such as " diluent distributing trough " and " diluent interconnection groove " in the prior art, it can be effective
The assembly precision reduced between restoring means complexity, reduction plug member and cartridge unit requires, also reduces manufacturing cost.
（3）Further, the present invention is prevented by the control liquid one-way flowing device being arranged at plug outlet port
Liquid medicine is flowed to by plug outlet port inside plug member, and then is flowed out from the diluent connector port.To
It realizes：When hybrid channel and plug member become single single piece, make medication reconstitution device have to liquid medicine into
The dry ability of row, to enable the medication reconstitution device of the present invention to realize the medicine dry for dry liquid drug, storage
Object restores the multiple functions such as dry drug.
（4）Further, the present invention is by moving internal diluent flow the improvement in path 7, to effectively promote diluent
The smooth degree for the input terminal 13 that hybrid channel 12 is flowed to through internal diluent flow path 7 simultaneously further decreases adding for plug member
Work manufacturing cost.
Description of the drawings
The plug member and the structural schematic diagram before cartridge unit cooperation that Fig. 1 is medication reconstitution device of the present invention.
The plug member and the cutting structural schematic diagram before cartridge unit cooperation that Fig. 2 is medication reconstitution device of the present invention.
The plug member and the cutting structural schematic diagram after cartridge unit cooperation that Fig. 3 is medication reconstitution device of the present invention.
Fig. 4 is the side upward view of the plug member of medication reconstitution device of the present invention.
Fig. 5 is the side vertical view of the cartridge unit of medication reconstitution device of the present invention.
Fig. 6 is the internal diluent flow path schematic diagram of medication reconstitution device of the present invention.
Fig. 7 a are a kind of preferred embodiment schematic diagrames of the internal diluent flow path of medication reconstitution device of the present invention.
Fig. 7 b are a kind of preferred embodiment schematic diagrames of the internal diluent flow path of medication reconstitution device of the present invention.
Fig. 8 be medication reconstitution device of the present invention preferred embodiment between outer jet connector port and output end
The schematic diagram in transhipment channel is set.
Fig. 9 is a kind of preferred embodiment upward view of the conduit wall of restoring means of the present invention.
Specific implementation mode
As shown in Fig. 1-3, Fig. 5, drug recovery receptacle device includes：Plug member 1 with proximal end 2, distal end 3 and is set
The side 4 between the proximal end 2 and the distal end 3 is set, the plug member 1 has external dilution agent connector port 5, and
With from the diluent connector port 5 to the internal diluent stream of the plug outlet port 6 of bottom at the distal end 3
Dynamic path 7；Cartridge unit 8 coordinates with the plug member 1, and there is cartridge part inner wall, the inner wall to have inner surface 9,
Internal cavity is formed in the inner surface 9, cartridge part 8 also has the distal end with outer jet connector port 10；Institute
Stating recovery receptacle device, also there is conduit wall 11, the conduit wall 11 to form hybrid channel, and the conduit wall 11 is formed in described
In the flat bottom surface of the distal end of plug member 1 so that the hybrid channel 12 has the top being closed and open bottom,
The height and length that the conduit wall 11 has are chosen to completely include the drug powder of whole amount in the hybrid channel 12,
Also retaining open space in the hybrid channel 12 simultaneously, the hybrid channel 12 has input terminal and 13 output ends 14,
When the plug member and cartridge part fit together, the output end 14 is connected to the outer jet connector end
Mouth 10；When the plug member and cartridge part fit together, 11 energy of bottom and conduit wall of the hybrid channel 12
Enough to be housed by the internal cavity of cartridge part 8, drug powder can be pushed into the mixing by the bottom 17 of the internal cavity
In channel, and contact the bottom for closing the hybrid channel 12 so that only by the input of the hybrid channel 12
End 13 and the offer of output end 14 approach the drug powder；And wherein, diluent is forced to be connected by the diluent
Device port makes the diluent flowing pass through the plug member 1, by the internal diluent flow path 7, the plug
Subexit port 6, flows into the input terminal 13 of the hybrid channel 12, and by the space in the hybrid channel 12 with
Drug powder contact, restores the drug powder with as conveying solution flows out the outer jet connector port 10,
Form the reconstituted solution with drug concentration gradient, the concentration ratio institute for the drug that the initial flow of the reconstituted solution has
The subsequent flowing for stating reconstituted solution wants high.
For the complexity for reducing when operating, the number of components of device composition is reduced, it is preferable that the integrated landform of the conduit wall 11
As a part for the plug member 1 so that the plug member 1 and the hybrid channel 12 are single components, and its
In, the bottom 17 of the internal cavity of cartridge part 8 has closure surfaces so that when being assembled with the plug member 1, is formed
The closing bottom of the hybrid channel 12.
As shown in figure 4, the input terminal of the neighbouring hybrid channel is additionally provided with closed-wall 16, the closed-wall 16 with it is affiliated
Conduit wall 11 is connected, and is closed to the opening of the input terminal.The closed-wall 16 can ensure that diluent is mixing
The flow direction from input terminal to output end is kept in channel, and prevents diluent from being flowed in opposite direction in hybrid channel.
It should be noted that the closed-wall 16 is not required in that, such as can be by the input terminal and cartridge unit of hybrid channel
The closure to the opening of the input terminal is realized in the cooperation of the inner surface 9 of wall.
As shown in fig. 6, from the diluent connector port 5 to plug outlet port 6, the internal diluent flows road
Diameter has successively：Center longitudinal path 18, lateral path 19 and side longitudinal path 20, this is a kind of " three-stage " composition side
Formula.The present invention is by being arranged the outlet port of plug member in plug member distal bottom, and neighbouring hybrid channel input terminal
The such construction in place, to be further discovered that：It can be by moving the improvement in path 7 to internal diluent flow, to effectively be promoted dilute
Release agent flowed to through internal diluent flow path 7 hybrid channel 12 input terminal 13 smooth degree and further decrease plug member
Processing and manufacturing cost.
Preferably, as shown in Figure 7a, internal diluent flow path 7 is only by mono- slant paths of a center longitudinal path 18+
" two-period form " mode constitute, plug outlet port 6 is set to the slant path at the end of neighbouring plug member distal bottom
End.Which cannot achieve under the design method that the prior art uses diluent distributing trough+diluent interconnection groove.It should
" two-period form " mode can effectively promote diluent and be flowed through internal diluent flow path 7 compared to above-mentioned " three-stage " mode
To the input terminal 13 of hybrid channel 12 smooth degree and due to the reduction of number of paths to be processed, to further save and drop
Stall off the processing and manufacturing step and cost of subassembly.And for injection product, for especially disposable injection product, processing system
The simplification and lower cost made just are particularly important.
It is highly preferred that as shown in Figure 7b, internal diluent flow path 7 is only by " one-part form " of a center longitudinal path 18
Mode is constituted, and uniform internal diameter size up and down may be used in center longitudinal path 18 at this time or upper inner diameter size is more than lower part
Internal diameter size（As shown in Figure 7b）Or lower inner diameter size is more than the constituted mode of upper inner diameter size.It is corresponding at this time,
The plug outlet port 6 is set to the central part of 1 distal bottom of plug member, and outer jet connector port 10 is set to
The close form peripheral edge portions of 8 distal bottom of cartridge unit；Or the plug outlet port 6 is set to 1 distal end bottom of plug member
The central part in portion, outer jet connector port 10 are set to the central part of 8 distal bottom of cartridge unit, and in outer jet
Setting transhipment channel 23 between connector port 10 and output end 14（As shown in Figure 8）." one-part form " mode of being somebody's turn to do is compared to above-mentioned
" two-period form " mode, " three-stage " mode, additionally it is possible to further promote diluent and be flowed to through internal diluent flow path 7
The smooth degree of input terminal 13 of hybrid channel 12 and being further reduced due to number of paths to be processed, so as to greatly
Save and reduce the processing and manufacturing step and cost of plug member.
The recovery receptacle device of the present invention, additionally it is possible to be used for dry liquid drug.For example, selecting the plug member 1
Outer shape so that before assembling the plug member 1 and cartridge part 8, the plug member 1 may be mounted at one
In support device, and the hybrid channel 12 is in open channels construction, and the open section of the hybrid channel 12 is upward
Direction, liquid medicine stay in unlimited cavity for processing to be dried；And wherein, the internal cavity of cartridge part 8
Bottom 17 have flat surface so that be dried to drug powder and the plug member 1 in the liquid medicine
After coordinating with cartridge part 8, the drug powder is pushed completely into the hybrid channel 12 by the flat surfaces, and is closed
Close the bottom of the hybrid channel 12；Wherein, the recovery receptacle device is used for dry liquid drug, stores dry drug simultaneously
Restore dry drug.
It during above-mentioned dry liquid drug, should take measures that liquid medicine is avoided to flow to by plug outlet port
Inside plug member, and then flowed out from the diluent connector port 5.Realize that the measure mode is various.Wherein, preferably
Mode one：The setting control liquid one-way flowing device at the plug outlet port 6（It is not shown in figure）, make liquid uniaxially
By the internal diluent flow path 7, the plug outlet port 6, the input terminal of the hybrid channel 12 is flowed into
13.Control liquid one-way flowing device can be selected from can control in the prior art liquid one-way flowing avoid the structure flow backwards and
Device.Preferably, the control liquid one-way flowing device is liquid non-return valve.
Preferred embodiment two：It is constructed in the internal diluent flow path 7 of above-mentioned " three-stage ", " two-period form ", " one-part form "
In mode, the structural member to match with the shape of the center longitudinal path 18 can be set in above-mentioned support device, to work as
When plug member 1 carries out liquid medicine drying in the support device, liquid medicine is avoided to pass through plug outlet end
Mouth flows to inside plug member, and then is flowed out from the diluent connector port 5.
For improve the storage of drug, restore it is horizontal, therefore, to assure that plug member and cartridge unit be fitted to each other after sealing
Property.Mode known in the art may be used in the sealing means.Wherein, preferred embodiment one：By plug member 1 and described
Cartridge unit 8 is adjacent in the proximal end of the plug member 1 to be fitted to each other；Between the plug member 1 and cartridge part 8
Sealing ring 15 is set so that the two is sealed after being fitted to each other.
Preferred embodiment two：The plug member 1 and cartridge part 8 are adjacent in the proximal end of the plug member 1
It is fitted to each other；It is adjacent to the place that is fitted to each other described, welding material is formed in the plug member 1 and cartridge part 8
On at least one so that suitable energy is applied to the welding material and the plug and cartridge part are sealed.
The welding manner can be selected from the similar approach of ultrasonic welding or such as laser welding.
Preferred embodiment three：Cartridge part 8 includes the first clamping close device, and the plug member 1 includes the second engaging
Device, second clamping close device are configured to coordinate with first clamping close device so that when the plug member 1 and the cylinder
When component 8 is combined together, first and second clamping close device is fitted to each other, and resists 1 He of the plug member securely
The dismounting of cartridge part 8.
Need further exist for explanation be：The bottom phase of the plug outlet port 6 and the distal end of the plug member 1
It positions adjacently, and plug outlet port 6 is in the specific location of the bottom of the distal end, it can be according to the input of the hybrid channel
The adaptable selection of end position, as long as can realize that diluent flows into hybrid channel input terminal from plug outlet port 6, then
Flow to hybrid channel output end.In preferably, the plug outlet port 6 is set to leaning on for 1 distal bottom of plug member
Nearly form peripheral edge portions or the central part for being set to 1 distal bottom of plug member.
The structural form of the conduit wall is various, as long as disclosure satisfy that guiding diluent from input terminal to output end
Flowing, and then it is communicated to outer jet connector port 10.Wherein, preferred embodiment one：Conduit wall surrounds wound upon themselves, with
Form hybrid channel with spiral shape.
Preferred embodiment two：As shown in figure 9, conduit wall includes a circumferential wall 21, from output end to defeated inside circumferential wall 21
Outlet is positioned apart from guiding wall 22 successively, and guiding diluent is flowed from input terminal to output end.
The outer jet connector port 10 is optionally set to the appropriate location of 8 distal bottom of cartridge unit, should
Easily it is connected with hybrid channel output end as long as the selection of position disclosure satisfy that.In preferably, outer jet connection
Device port 10 is set to the close form peripheral edge portions of 8 distal bottom of cartridge unit or is set in 8 distal bottom of cartridge unit
Center portion point.
The internal cavity be dimensioned to can at least to house the bottom of the hybrid channel 12 and conduit wall 11 and
It at least can include the liquid medicine of the predetermined amount for being dried to drug powder.
Although in addition, have shown that and describe several embodiments and preferred embodiment of present general inventive concept,
It is that it should be appreciated by those skilled in the art, can be right in the case where not departing from the principle and spirit of present general inventive concept
These embodiments are changed, and the present general inventive concept is limited by claim and its equivalent.
Claims (10)
1. a kind of recovery receptacle device for restoring dry drug, the recovery receptacle device include：Plug member（1）,
With proximal end（2）, distal end（3）With setting in the proximal end（2）With the distal end（3）Between side（4）, the plug member
（1）With external dilution agent connector port（5）, and have from the diluent connector port（5）To positioned at the distal end
（3）Locate the plug outlet port of bottom（6）Internal diluent flow path（7）；
Cartridge unit（8）, with the plug member（1）There is inner wall, the inner wall to have inner surface for cooperation, cartridge part
（9）, in the inner surface（9）Interior formation internal cavity, cartridge part（8）Also have and carries outer jet connector port（10）
Distal end；
Conduit wall（11）, the conduit wall（11）Form hybrid channel, the conduit wall（11）It is formed in the plug member（1）
Distal end so that the hybrid channel（12）Top with closure and open bottom, the conduit wall（11）The height having
Degree and length are chosen in the hybrid channel（12）The drug powder of whole amount is inside completely included, while also logical in the mixing
Road（12）It is middle to retain open space, the hybrid channel（12）With input terminal（13）And output end（14）, when the plug
When component (1) and cartridge part (8) fit together, the output end（14）It is connected to the outer jet connector port
（10）；
When the plug member (1) and cartridge part (8) fit together, the hybrid channel（12）Bottom and channel
Wall（11）It can be by cartridge part（8）The internal cavity house, drug powder can be pushed by the bottom of the internal cavity
In the hybrid channel, and contacts and close the hybrid channel（12）Bottom so that only by the hybrid channel
（12）The input terminal（13）And output end（14）Offer approaches the drug powder；And wherein, diluent is forced
The diluent flowing is made to pass through the plug member by the diluent connector port（1）, it is dilute by the inside
Release agent flow path（7）, the plug outlet port（6）, flow into the hybrid channel（12）The input terminal（13）, and pass through
Cross the hybrid channel（12）In space to be contacted with the drug powder, restore the drug powder with conveying solution
Flow out the outer jet connector port（10）, the reconstituted solution with drug concentration gradient is formed, the reconstituted solution
The subsequent flowing of reconstituted solution described in the concentration ratio for the drug that initial flow has wants high.
2. recovery receptacle device according to claim 1, wherein the conduit wall（11）It is formed integrally as the plug
Component（1）A part so that the plug member（1）With the hybrid channel（12）It is single component, and wherein, it is described
Cartridge unit（8）The internal cavity bottom（17）With closure surfaces so that with the plug member（1）When assembling, formed
The hybrid channel（12）Closing bottom.
3. recovery receptacle device according to claim 1, wherein：With the proximal end（2）, distal end（3）, side（4）, it is outer
Portion's diluent connector port（5）, the plug outlet port（6）The plug member（1）And the conduit wall（11）With
And the hybrid channel（12）All be formed as single first single piece together；And cartridge part（8）The inner wall, described
Internal cavity and the outer jet connector port（10）All be formed as single second single piece together；Wherein, the recovery is held
Device device is only made of two components.
4. recovery receptacle device according to claim 3, wherein：The plug member（1）With cartridge part（8）In institute
State plug member（1）The proximal end be adjacent to and be fitted to each other；The plug member（1）With cartridge part（8）Between be arranged
There is sealing ring（15）So that the two is sealed after being fitted to each other.
5. recovery receptacle device according to claim 3, wherein the plug member（1）With cartridge part（8）In institute
State plug member（1）The proximal end be adjacent to and be fitted to each other；It is adjacent to the place that is fitted to each other described, welding material is formed in institute
State plug member（1）With cartridge part（8）At least one of on so that suitable energy is applied to the welding material will
The plug and cartridge part are sealed.
6. recovery receptacle device according to claim 1, wherein cartridge part（8）Including the first clamping close device, and
The plug member（1）Including the second clamping close device, second clamping close device is configured to coordinate with first clamping close device,
So that working as the plug member（1）With cartridge part（8）When being combined together, first and second clamping close device is matched each other
It closes, and resists the plug member securely（1）With cartridge part（8）Dismounting.
7. recovery receptacle device according to claim 1, wherein from the diluent connector port（5）To the plug
Subexit port（6）, successively, the internal diluent flow path（7）By being located at the plug member（1）In internal one
Heart longitudinal path（18）, a lateral path（19）With a side longitudinal path（20）Composition；Or successively, by being located at the plug
Subassembly（1）An internal center longitudinal path（18）It is formed with a slant path；Or by being located at the plug member（1）It is interior
The one center longitudinal path in portion（18）Composition.
8. recovery receptacle device according to claim 1, is additionally operable to dry liquid drug；Wherein, the plug part is selected
Part（1）Outer shape so that by the plug member（1）With cartridge part（8）Before assembling, the plug member（1）
It may be mounted in support device, and the hybrid channel（12）In open channels construction, and the hybrid channel（12）
Open section stayed in unlimited cavity upwardly toward, liquid medicine for processing to be dried；And wherein, cartridge part
（8）The internal cavity bottom（17）With flat surface so that be dried to drug powder in the liquid medicine
And the plug member（1）With cartridge part（8）After cooperation, the drug powder is pushed completely by the flat surfaces
The hybrid channel（12）In, and close the hybrid channel（12）Bottom；Wherein, the recovery receptacle device is used for drying
The dry drug of liquid medicine, storage simultaneously restores dry drug.
9. recovery receptacle device according to claim 8, the plug outlet port（6）It is unidirectional that place is provided with control liquid
Flow device makes liquid uniaxially pass through the internal diluent flow path（7）, the plug outlet port（6）, flow into institute
State hybrid channel（12）The input terminal（13）.
10. recovery receptacle device according to claim 8, the control liquid one-way flowing device is liquid non-return valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810197538.4A CN108498903A (en) | 2018-03-11 | 2018-03-11 | Medication reconstitution device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810197538.4A CN108498903A (en) | 2018-03-11 | 2018-03-11 | Medication reconstitution device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108498903A true CN108498903A (en) | 2018-09-07 |
Family
ID=63377434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810197538.4A Pending CN108498903A (en) | 2018-03-11 | 2018-03-11 | Medication reconstitution device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108498903A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004108193A1 (en) * | 2003-05-30 | 2004-12-16 | Eli Lilly And Company | Multiple chamber medication dispensing apparatus |
| CN103582473A (en) * | 2011-01-10 | 2014-02-12 | 拜昂·塞翁·常 | Compact medication reconstitution device and method |
| US20160067144A1 (en) * | 2014-09-09 | 2016-03-10 | Byeong Seon Chang | Solution Delivery Device and Method |
| CN209253833U (en) * | 2018-03-11 | 2019-08-16 | 杨一博 | Medication reconstitution device |
-
2018
- 2018-03-11 CN CN201810197538.4A patent/CN108498903A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004108193A1 (en) * | 2003-05-30 | 2004-12-16 | Eli Lilly And Company | Multiple chamber medication dispensing apparatus |
| CN103582473A (en) * | 2011-01-10 | 2014-02-12 | 拜昂·塞翁·常 | Compact medication reconstitution device and method |
| US20160067144A1 (en) * | 2014-09-09 | 2016-03-10 | Byeong Seon Chang | Solution Delivery Device and Method |
| CN209253833U (en) * | 2018-03-11 | 2019-08-16 | 杨一博 | Medication reconstitution device |
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