CN108478918A - A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof - Google Patents
A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof Download PDFInfo
- Publication number
- CN108478918A CN108478918A CN201810559232.9A CN201810559232A CN108478918A CN 108478918 A CN108478918 A CN 108478918A CN 201810559232 A CN201810559232 A CN 201810559232A CN 108478918 A CN108478918 A CN 108478918A
- Authority
- CN
- China
- Prior art keywords
- microtubular
- moulding
- brace
- data packet
- aneurysm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0041—Catheters; Hollow probes characterised by the form of the tubing pre-formed, e.g. specially adapted to fit with the anatomy of body channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Surgical Instruments (AREA)
Abstract
The invention belongs to the field of medical instrument technology, provide a kind of aneurysm intervention operation moulding auxiliary brace of microtubular；Moulding difficulty is carried out to microtubular before aneurysmal surgical procedure is treated for solving of the existing technology by the way of microtubular interventional embolization, it is moulding not accurate, dependent on doctor's subjective judgement to it cannot be guaranteed that microtubular once moulding success and the technical issues of extend operating time, even result in operative failure.Meanwhile the present invention also provides a kind of methods for making the moulding auxiliary brace of above-mentioned microtubular, so that the auxiliary brace consistent with the sufferer lesion angio-architecture is made and obtained according to the different configuration of different sufferers and sufferer blood vessel.By the restriction and constraint that assist brace, it can disposable precise forming using conventional high temperature fumigation, greatly improve the accuracy moulding to microtubular, one-pass molding can save a large amount of preoperative preparation time, avoid it is repeatedly moulding in art and the problem of be delayed operating time.
Description
Technical field
The invention belongs to the field of medical instrument technology, more particularly to carry out the auxiliary of aneurysm treatment using intervention procedures
Help medical instruments field, and in particular to a kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof.
Background technology
Aneurysm generally refers to intracranial aneurysm, is that the localized abnormality of cerebral artery expands, the most normal with hepatic hydatid disease
See, there is also netraneurysm, dissecting aneurysm, false aneurysms etc..Intracranial aneurysm is caused under spontaneous arachnoid
Chamber bleeding (SAH) most common reason.
In the prior art, aneurysmal treatment can be divided by early operation (6~96 is small after SAH according to operating time
When) and late surgery (10~14 days or more).4~10 days after SAH, surgical effect was poor.Modus operandi includes Direct Surgery
Folder closes aneurysm and Treatment of Endovascular Embolization aneurysm.Common modus operandi includes neck clipping, Reinforcement, isolated art or proximal end
Ligation.It by certain embolism materials includes various types of take off that Treatment of Endovascular Embolization technology, which is by microtubular technology,
Property spring ring, sacculus, non-adhesive liquid embolizing agent or covered stnet etc. be placed on intracranial aneurysm intracavitary, it is dynamic to reach occlusion
The purpose of arteries and veins tumor, this method, which is suitable for performing the operation pressing from both sides to close difficulty or press from both sides, closes unsuccessfully aneurysm, elderly patients, wide neck aneurysm, complexity
Aneurysm, dissecting aneurysm and false aneurysm.Wherein, embolism is carried out using microtubular technology and is presently the most common one
The drawbacks of planting therapeutic modality, but there are some in the course of surgery clearly.
Main problem of the existing technology is to be in operation consent or operation that time for delaying is long, and lead due to micro-
Moulding inaccuracy is managed, the microtubular caused in operation intervenes obstacle, the aneurysm that cannot quickly fill embolism materials
In, to inevitably extend operating time and to microtubular moulding problems repeatedly.Carrying out microtubular embolism Jie
Enter operative treatment it is aneurysmal during, it usually needs by CT angiographic imagings (CTA) or equivalent belong to ability
The common MRA of field technique personnel, the modes such as DSA are by the vascular distribution of affected area and angio-architecture and aneurysmal connection position
It sets situation and carries out three-dimensional presentation, the blood vessel moulding that doctor is imaged according to CT by microtubular using manually by being wrapped in curvature arc
Degree is substantially equal on the draw point of lesion blood vessel curvature, and carries out high temperature fumigation, and microtubular is moulding to reach, and the purpose of sizing is no
Then, during carrying out microtubular intervention blood vessel, since the vascular bending amplitude of affected area is big, construction is complicated, if micro- lead
The natural form of pipe and blood vessel and aneurysmal formation are inconsistent, and the very difficult embolism filler by microtubular is sent to
Blocking is filled in aneurysm；So giving the operation of this reason to be often repeated and influence what sufferer treated and performed the operation
Successful.Microtubular in the prior art is moulding to be all made of doctor's shaped by hand, and with reference to shown in attached drawing 7, doctor is according to CT radiographies
Microtubular 1 is wrapped in the steel by the radius of curvature of the image range estimation blood vessel after imaging, the draw point 7 for then choosing corresponding size
On needle 7, recycles high-temperature steam to be fumigated, achieve the purpose that carry out microtubular 1 moulding.Due to the blood of each patient
Pipe distribution is all different, and the subjective judgement of the experience for the doctor that places one's entire reliance upon in the prior art, there are great errors, thus
Moulding precision cannot be guaranteed, lead to subsequent procedures carries out that there are the increases of the probability of obstacle.
In the following, several applicants existing patent document associated with this application retrieved is provided, it is specific as follows：
The prior art 1：
Chinese utility model patent, application number：201621075826.5 the applying date：2016-09-23, synopsis：It should
Utility model, which discloses one kind, can expand catheter sheath and intervention apparatus conveying device, the catheter sheath that the utility model can expand, including pipe
Wall, the tube wall are volume wall construction, and cross section is winding escalator, and the tube wall is with expansion corresponding site volume wall construction by swollen
State and the pre-setting state for voluntarily restoring winding-structure, the utility model catheter sheath have specific cross sectional shape,
When conveying intervention apparatus, only changes shape according to the external dimensions of intervention apparatus on the position that intervention apparatus passes through and (cut
Area), it after intervention apparatus passes through, can restore to the state of former pre-setting by natural resiliency, be conducive to penetrate thinner blood vessel,
It avoids calcification plate from falling off, reduces operation risk.
The prior art 2：
Chinese invention patent application, application number：201510582773.X the applying date：2015-09-15, synopsis：It should
Invention belongs to field of medical devices, more particularly to is suitable for the plugging device that patent ductus arteriosus patient carries out transcatheter operation.
A kind of patend ductus arteriosus occluder, including one first disk, a cylindrical packing, first disk and cylinder are filled out
Cock body is woven by alloying metal silk, and a bent sizing is equipped between first disk and cylindrical packing and is supported
Interconnecting piece.The disk of first disk of heretofore described plugging device/second is connect by interconnecting piece with cylindrical type packing,
The interconnecting piece have certain activity, can angulation, vascular wall can be preferably bonded, to reduce aorta deformation and
The risk of luminal stenosis.
The prior art 3：
Chinese invention patent application, application number：201210157647.6 the applying date：2012-05-18, synopsis：It should
A kind of support frame positioning device in openings in blood vessels lesion interventional treatment of disclosure of the invention, it is by long filament and with can
The housing structure of the angle of expansion is constituted.Housing structure and long filament together send stent delivery system to needing to be implanted into holder
Blood vessel opening position.Angle plays the role of positioning and support.Angle is released from guiding catheter by long filament,
Realize it is arterial vascular adherent, and the development section of angle can be formed one development plane.Present invention processing is simple, is one
Body winding structure, heat treatment process sizing, relative cost is low, easy to use.
It is above-mentioned in the prior art, led to micro- in the unresolved especially aneurysmal interventional embolization operation about aneurysm
Pipe carries out quick and precisely moulding technical problem.
Invention content
Present invention aims at provide a kind of aneurysm intervention operation moulding auxiliary brace of microtubular；It is existing for solving
Moulding be stranded is carried out to microtubular before treating aneurysmal surgical procedure existing for technology by the way of microtubular interventional embolization
Difficulty, moulding not accurate, the subjective judgement and operating experience of the doctor that needs to rely on, to it cannot be guaranteed that microtubular is once moulding
The technical issues of succeeding and extending operating time, even result in operative failure.Meanwhile the present invention also provides one kind for making
The method of the above-mentioned moulding auxiliary brace of microtubular, to make and obtain according to the different configuration of different sufferers and sufferer blood vessel
Obtain the auxiliary brace consistent with the sufferer lesion angio-architecture.By assisting the restriction and constraint of brace, using conventional high temperature
It is stifling can disposable precise forming, greatly improve the accuracy moulding to microtubular, one-pass molding can save greatly
The preoperative preparation time of amount, avoid it is repeatedly moulding in art and the problem of be delayed operating time, it is moulding to doctor to eliminate microtubular
The problem of dependence of raw experience and subjective judgement ability.
Meanwhile auxiliary brace of the present invention still belongs to pioneering, clinic not yet finds similar auxiliary brace at present
It generates, is all to perform the operation to need by the voluntarily manually stifling operation according to the micro-judgment of itself by surgeon.Therefore,
Efficiency and stability are very uncontrollable.
The technical solution adopted in the present invention is：
The production method of the moulding auxiliary brace of a kind of aneurysm intervention operation microtubular, for utilizing steam to intervening brain
The microtubular progress of blood vessel is quickly moulding, and the microtubular and intervention being adapted with acquisition and focal arterial tumor and shape of blood vessel are dynamic
Arteries and veins tumor carries out Treatment of Endovascular Embolization；The making of the moulding auxiliary brace of microtubular specifically includes following steps：
Step S01 obtains lesion blood vessel and aneurysmal CT images data packet A01 using CT angiography scans；
The CT images data packet A01 that step S01 is obtained is imported and be can recognize that the CT images data packet A01 by step S02
Medical science modeling software and obtain it is corresponding with A01 parameters and with CAD general formats preservation 3D mathematical model data packets B01；
Similarly, STL general formats can also be used, it, can be according to physical device subject to specific formatted data can be identified by equipment
Flexibly setting, it is not described here in detail.
Step S03, the 3D mathematical model data packets B01 that step S02 is obtained into edlin, and obtain shape with it is described
3D mathematical model data packets B01 is consistent, and editor's 3D mathematical model data packets B01 obtains the casing data packet B02 of inner hollow；
Casing data packet B02 is edited, the casing model data packet C01 with multiple notches being in communication with the outside is obtained；
Step S04, by the described sleeve pipe model data packet C01 obtained in step S03 import using SLS it is powder sintered at
3D printing is carried out in the 3D printer of type obtains the auxiliary brace moulding for aneurysm intervention operation microtubular.
As the preferred embodiment of the present invention, the contrast agent that CT angiographies use described in above-mentioned steps S01 is iodine reagent
Or carbon dioxide is as contrast agent；The operating procedure of angiography is：Contrast agent is injected by the way of intravenous injection and is suffered from
It while in person's body or uses CT contrast enhancements or plain CT to be scanned lesions position at once and obtains CT images number
According to packet A01.
As the preferred embodiment of the present invention, medical science modeling software described in above-mentioned steps S02 be Mimics or
Arigin3D。
As the preferred embodiment of the present invention, the casing model data packet C01 packets of inner hollow are obtained in above-mentioned steps S03
Include following steps：
Step S031 determines the arbitrary section on the mathematical model length of vessel direction in 3D mathematical model data packets B01
Calibration central point On；
Step S032 obtains aneurysm in 3D mathematical model data packets B01 and extends 2cm-5cm's to proximal part along blood vessel
The calibration central point O in multiple sections on length of interval1-On；
Step S033, by the center point set obtained in step S032 according to O1-OnSequence pass sequentially through natural curve
Connection obtains curve ι1；
Step S034, with the curve ι obtained in step S0331On the basis of respectively scan that obtain outer diameter be 3.3mm-6mm
3D solid L2With the 3D solid L that outer diameter is 2.5mm-5mm3；Pass through 3D solid L2Subtract 3D solid L3Obtaining wall thickness is
The casing data packet B02 of 0.8mm-1.0mm；Casing data packet B02 is edited, is covered according to the multiple notches of blood vessel curvature editor
Tube model data packet C01.
It is further preferred that by 3D solid L3Outer diameter to be set as 3mm be best；From the angle of specific theoretical modeling
For degree, 3D solid L3Outer diameter be more than and be infinitely close to microtubular outer diameter be in terms of moulding constraint it is more accurate,
It is effectively moulding to microtubular progress more to be matched with the form of the actual focal blood vessel of sufferer afterwards；But it is steamed to microtubular
In vapour moulding process, if the hollow channel and 3D solid L of microtubular and set tube model3Outer diameter be too close to, can bring
Following operating barrier：One, doctor need microtubular being inserted into molding by 3D printing before progress microtubular is moulding
In the moulding channel of brace ontology, at this point, the internal diameter in moulding channel and the outer diameter of microtubular get too close to that doctor can be directly resulted in
Microtubular is inserted into extremely difficult in moulding channel, is not easy to be inserted into；Secondly, carry out high-temperature steam it is stifling when, if moulding logical
Gap more than road between microtubular is too small, and steam can not adequately wrap up microtubular, and microtubular can exist heated
Uneven and moulding deformity occur, different from the form in moulding channel, compactness is not high and can not use.
If the internal diameter enlarged meeting in moulding channel is improved directly and significantly microtubular during high-temperature steam is stifling
It is further preferred, the calibration central point O in above-mentioned steps S031nMethod of determination include the following steps：
Step S0311, the arbitrary section chosen on the mathematical model blood vessel in step S031 is as rectangular coordinate system
In, and respectively by section it is extremely upper, extremely under, ultra-Left and ultra-Right four several points be demarcated as point E, point F, point G and point H respectively；
Step S0312, the extremely upper point E and extremely lower point F of connection, and find out the midpoint M of line segment EF；Connect ultra-Left point G and ultra-Right
Point H, and find out the midpoint N of line segment GH；MN is connected, and determines that the midpoint of line segment MN is the calibration central point O in the sectionn。
It is worth noting that：The final purpose of above-mentioned determining method is to determine the mathematical model of corresponding lesion blood vessel
Central axis, to obtain the model consistent with vascular bending curvature.From the angle of mathematical modeling including but not limited to above-mentioned side
Method can realize this effect, for example use the algorithm of calculus that can get one and be infinitely bonded with the angiography
Central axis；But due to the needs of actual operation, can inevitably be generated when carrying out moulding in addition model and microtubular it
Between gap error.And microtubular itself have certain elasticity, so after moulding can not possibly reach 100% it is consistent,
During actual operation, certain elastic allowance is also allowed for the bending curvature and compactness of microtubular.Therefore, to sum up institute
It states, carries out modeling determining central point O using aforesaid waynCan be most fast, it is most efficiently completed modeling, is shortened to the greatest extent
Operation preparation time, especially encounters the case where being adjusted in art, and operation preparation time is then extremely important.
Further preferably, the selection quantity in multiple sections described in step S032 with the increase of corresponding blood vessel curvature and
Increase, and the vertical range between two neighboring section is no more than 1mm.
The present invention also provides a kind of aneurysms to intervene the operation moulding auxiliary brace of microtubular, including brace ontology, the branch
Have body interior and have and moulding channel for accommodating microtubular is set along brace body length direction, on the brace ontology
Be provided with the notch of multiple hollow outs being connected to the moulding channel, formed between the two neighboring notch one with it is described
This body by integral forming of brace is used to limit the moulding ring of the microtubular.
In order to take into account the cost for making the moulding auxiliary brace of the microtubular, quality and efficiency, the brace ontology simultaneously
Material be glass fibre or nylon powder by the powder sintered molding 3D printer sintering printings of SLS.
In order to ensure microtubular can preferably be bonded the brace ontology in carrying out high temperature fumigation moulding process, obtain
The natural curve form with moulding channel always is obtained, is especially arranged using following preferred embodiments：The notch is along brace body shaft
To 2-5 times of the length that the length of length direction is moulding ring；The axial length of the moulding ring is 1-4mm.
It is further preferably, the notch along the length that the length of brace ontology axial direction length direction is moulding ring 3
Times；The axial length of the moulding ring is 2mm.
Beneficial effects of the present invention are：
(1) the aneurysm intervention operation moulding auxiliary brace of microtubular provided by the invention can substitute existing doctor completely
Raw complicated processes moulding to microtubular by the way of manually winding, meanwhile, it is capable to avoid it is existing manually wind it is moulding in it is right
The dependence of the experience and operational capacity of doctor eliminates the artificially influence to moulding effect, avoids quality low, success rate is low to be caused
The problem of microtubular is scrapped.
(2) present invention carries out operative constraint by the way that multiple notches and moulding ring are arranged on brace ontology to microtubular
Steam can also be enable adequately to wrap up entire microtubular simultaneously, so that microtubular is heated evenly, moulding effect is good, with blood vessel
Form compactness it is high, avoid it is manually moulding middle repeatedly moulding caused by estimating inaccurate or misoperation due to extend it is moulding
Time.
(3) present invention scans by using CTA and obtains original image, is modified by medicine modeling, acquisition is arbitrarily thought
What is obtained is directed to the 3D shape of the auxiliary brace of individual case, then auxiliary brace is obtained by way of 3D printing, can
The disposable auxiliary brace obtained with any special case lesion blood vessel same structure is different straight without preparing in the prior art
The blood vessel that the various draw points of diameter carry out different curvature is moulding.
Description of the drawings
Fig. 1 be it is moulding after microtubular structural schematic diagram；
Fig. 2 is obtuse angle aneurysm structural schematic diagram；
Fig. 3 is right angle aneurysm structural schematic diagram；
Fig. 4 is acute angle aneurysm structural schematic diagram；
Fig. 5 is the structure chart of notch auxiliary brace in the present invention；
Fig. 6 is the structure chart of the outer notch auxiliary brace of the present invention；
Fig. 7 is the moulding schematic diagram of the prior art described in background technology；
In figure：1- microtubulars；The moulding channels 2-；3- brace ontologies；The moulding rings of 4-；5- notches；6- aneurysms；7- draw points；
8- blood vessels.
Specific implementation mode
Before to present invention progress specific embodiment and/or preferred embodiment illustrate one by one, applicant should say
It is bright, it is of the present invention that the microtrauma type surgery hand that operation is very common for treating aneurysm is intervened for aneurysm
Art, but in order to ensure the successful and feasibility of operation, it is necessary to it is moulding to microtubular progress, so that microtubular can smoothly simultaneously
It successfully gets involved in aneurysm, embolism filler, such as metal elastic spring coil etc. is sent in aneurysm, make its blood flow
Speed continuously decreases until generate thrombus and completely plugged aneurysm, avoids aneurysm rupture occurs leading to the mesh of sufferer death
's.
At present on the market it is not yet found that any for substituting or assisting to carry out microtubular moulding, guarantee microtubular
Moulding is quick, the auxiliary device of accuracy, and therefore, auxiliary brace of the present invention should belong to pioneering invention；Institute of the present invention
The maximum distinctive points that the method for stating is different from the prior art have at 2 points：
One, the method for the present invention it is creative embolotherapy is carried out to Interventional aneurysm during, disposably to micro-
Conduit carries out the making of moulding auxiliary brace；
Secondly, the method for the present invention by CTA is scanned (CT angiographies) acquisition blood vessel and aneurysmal radiography, and
The three-dimensional radiography of acquisition is obtained into the casing model data packet C01 for having notch 5 and moulding ring 4, then by data edition
Carrying out printing shaping acquisition in the mode Jing Guo 3D printing can be with the matched brace ontology of blood vessel moulding of any different configuration
3, to meet any sufferer, the purpose of any abnormity construction aneurysm interventional embolization.It is worth noting that MRA is Magnetic
The abbreviation of Resonance Angiography, refers to Magnetic Resonance Angiography, magnetic resonance can row angiography, that is, show blood
Pipe, it is possible to find the position of hemadostewnosis and occlusion.Basic functional principle is gone based on saturation effect, inflow enhancement effect, flowing
Phase effect.MRA is that presaturation band is placed in the head end of 3D layers of block to be saturated venous blood flow, the arterial blood of reverse flow into
Enter 3D layers of block, because not being saturated to generate MR signals.It is divided into multiple thin layers to excite a thicker volume when scanning, subtracts
Few excitation volume thickness can guarantee scanning volume range to reduce inflow saturation effect, obtain the thin layer of several layers of adjacent level
Image makes image clearly, the fine structure of blood vessel show, spatial resolution improves.
Digital subtraction angiography (Digital subtraction angiography) abbreviation DSA, i.e. angiography
Image by digitized processing, unwanted tissue image is deleted, artery-sparing image, this technology is called number
Word deshadowing technology, its main feature is that image clearly, high resolution, to observing vascular lesion, the positioning measurement of hemadostewnosis, diagnosis
And interventional treatment provides true stereo-picture, and necessary requirement is provided for various interventional treatment.It is primarily adapted for use in whole body blood
The inspection and treatment of pipe disease and tumour.The diagnosing and treating that interventional treatment is angiocardiopathy is carried out using DSA to open
One new field.It is mainly used in the diagnosing and treating of coronary heart disease, arrhythmia cordis, valvular heart disease and congenital heart disease.It is above-mentioned
DSA, MRA, CTA can realize that required radiography models basic data acquisition function, this is to those skilled in the art
It is well known, is not detailed！
Below in conjunction with the accompanying drawings and specific embodiment does further explaination to the present invention.
Embodiment 1：
The production method of the moulding auxiliary brace of a kind of aneurysm intervention operation microtubular, for utilizing steam to intervening brain
The microtubular progress of blood vessel is quickly moulding, and the microtubular and intervention being adapted with acquisition and focal arterial tumor and shape of blood vessel are dynamic
Arteries and veins tumor carries out Treatment of Endovascular Embolization；The making of the moulding auxiliary brace of microtubular specifically includes following steps：
Step S01 obtains lesion blood vessel and aneurysmal CT images data packet A01 using CT angiography scans；
The CT images data packet A01 that step S01 is obtained is imported and be can recognize that the CT images data packet A01 by step S02
Medical science modeling software and obtain it is corresponding with A01 parameters and with CAD general formats preservation 3D mathematical model data packets B01；
Step S03, the 3D mathematical model data packets B01 that step S02 is obtained into edlin, and obtain shape with it is described
3D mathematical model data packets B01 is consistent, and editor's 3D mathematical model data packets B01 obtains the casing data packet B02 of inner hollow；
Casing data packet B02 is edited, the casing model data packet C01 with multiple notches 5 being in communication with the outside is obtained；Such as Fig. 5 institutes
Show；
Step S04, by the described sleeve pipe model data packet C01 obtained in step S03 import using SLS it is powder sintered at
3D printing is carried out in the 3D printer of type obtains the auxiliary brace moulding for aneurysm intervention operation microtubular.
Producing principle and purpose are summarized：
The present invention is scanned to the affected area of sufferer by CT angiographic apparatus, and CT images data packet is obtained
A01, CT images data packet A01 are the formatted datas that existing equipment uniformly exports, and can pass through plurality of medical modeling software
It reads, and is converted into editable CAD general formats；Since the most important purpose of the present invention is to obtain and sufferer angio-architecture
Identical auxiliary brace 3, then abovementioned steps are to obtain three-dimensional blood vessel image using the prior art and be converted into editable number
According to.Most important as the present invention, most crucial step is, the initial three-dimensional angiography image editing of acquisition is become can be with
It is directly inputted to the casing model data packet C01 that the moulding requirement of steam is printed and met in 3D printer.It is worth explanation
It is, since the lesion blood vessel of different sufferers or aneurysmal growing state are had nothing in common with each other, according to the present embodiment method and step
S03 can be arbitrarily to 3D mathematical model data packet B01 into edlin, to obtain best casing model data packet C01.Example
Such as, in editor casing data packet B02, the mistake of the casing model data packet C01 with multiple notches 5 being in communication with the outside is obtained
Cheng Zhong can freely determine the size of the notch 5, length and quantity, in order to meet difference according to actual angio-architecture
The moulding demand of bending of blood vessel curvature.
It is worth noting that as it will be apparent to those skilled in the art that for 3D mathematical model data packets B01,
When casing data packet B02 is into edlin, the size and number of notch 5 can be set according to the subjective judgement of doctor or freely,
Per increase a notches 5 will more channels enter for follow-up steam moulding process high temperature steam and microtubular 1 carries out
Contact heat is transmitted, to increase the plasticity of microtubular 1 and the uniformity of plastic deformation.Therefore, the quantity of notch 5 is more, meeting
The moulding efficiency of steam is improved, but can't enhance or weaken thermoplastics type mass of the steam to microtubular 1；So Yi Shengke
According to actual formality situation, the mode of the size and quantity and notch direction of notch 5 is freely arranged, further combined with
Shown in Fig. 6, the direction of notch 5 is consistent with the data model bending direction of blood vessel, then belongs to interior notch setting；Conversely, then belonging to
Outer notch setting；Under normal conditions, interior notch or outer scarce can be used arbitrarily in the notch on more straight angio-architecture
Mouth is arranged alternately, and the steam for not interfering with the later stage is moulding.When vascular bending curvature is bigger and single described scarce
When the length of mouth 5 is larger, it is preferred to use interior notch mode is arranged, and can provide better binding character to microtubular 1 in this way.
Embodiment 2：
As the preferred embodiment of the present invention, on the basis of embodiment 1, what CT angiographies described in step S01 used
Contrast agent is iodine reagent or carbon dioxide as contrast agent；The operating procedure of angiography is：By the way of intravenous injection
Lesions position is swept while contrast agent is injected patient's body or at once using CT contrast enhancements or plain CT
It retouches and obtains CT images data packet A01.
Quantity at each position and distribution after contrast agent enters in vivo, according to lesion blood vessel structure the characteristics of present it is certain
Density and morphological differences, clinical practice fully proves, enhancing scanning significantly improves the resolution ratio of certain organ CT examinations
And accuracy rate of diagnosis, by taking cranium brain CT examination as an example, the accuracy rate of plain CT is 82%, and the accuracy rate for enhancing scanning rises to
92%-95%.Suitable for each portion's macroangiopathy of whole body, vascular malformation, aneurysm, vascular occlusion with the detection of bleeding and from
It is dynamic to generate radiography data, i.e. CT images data packet A01.
Embodiment 3：
As the preferred embodiment of the present invention, on the basis of above-described embodiment 1 or embodiment 2, described in the step S02
Medical science modeling software be Mimics or Arigin3D.Operating procedure explanation is carried out by taking Mimics as an example below：
Above-mentioned CT images data packet A01 imported into Mimics, is observed by Mimics and adjust former CT by the first step
Influence the threshold value of data packet A01；
Second step chooses required picture material according to the adjustment of threshold value after obtaining the clear 3-D view of angiography,
Determine the whole radiography images for needing subsequently to be modeled；
Third walk, by present in all radiography images chosen cavity or missing place completely fill out, avoid because
Lead to model existing defects for threshold value step-up error；
4th step, establishes threedimensional model, it is generally the case that runs Calculate orders in Mimics and produces three
The bitmap for tieing up figure, decides whether to handle picture according to the clear situation of picture and actual demand；
5th step, exports ansys files and according to ansys area files model split grids, by Mimics into
Row assignment sets and automatically generates threedimensional model, i.e. 3D mathematical models data packet after (MPa) after unit intensity (HU) and e modulus
B01。
It is worth noting that above-mentioned is to the explanation for establishing the progress of medical data model by taking Mimics as an example, including but not
It is limited to using the software realization other than Mimics.
Embodiment 4：
As the preferred embodiment of the present invention, on the basis of any of the above-described embodiment, obtained in inside in the step S03
Empty casing model data packet C01 includes the following steps：
Step S031 determines the arbitrary section on the mathematical model length of vessel direction in 3D mathematical model data packets B01
Calibration central point On；Due to the most rounded or similar round shape of the global shape in section, and pass through CT images data packet
The blood vessel image that A01 is obtained belongs to the three-dimensional of entity, needs the center line for finding solid threedimensional blood vessel as far as possible, then root
The expansion or diminution that equal proportion is carried out according to the center line, could more fit in true angio-architecture, therefore, center line
Closer to the geometric center of vascular cross-section, the casing model data packet C01 that constructs is mutually unison with actual angio-architecture
It will be higher；But from actual demand, since microtubular 1 is that have certain elasticity and toughness, it is situated between for operation
The needs entered, a hundred percent without accomplishing theoretical is accurate, can allow certain error, these errors can't cause hand
The difficulty and obstacle of art intervention.
Step S032 obtains aneurysm in 3D mathematical model data packets B01 and extends 2cm-5cm's to proximal part along blood vessel
The calibration central point O in multiple sections on length of interval1-On；Due to when carrying out interventional embolization operation, it is crucial that will lead
The end of pipe is inserted into inside the aneurysm of affected area, and described dynamic by being transported to by microtubular 1 for the filler of embolism
In arteries and veins tumor, therefore, for the angle between the aneurysm 6 and blood vessel 8 of different angle in such as Fig. 2-4, microtubular 1 needs to carry out
It is effectively moulding, carry out embolotherapy in order to which microtubular 1 to be smoothly inserted into specified aneurysm 6.I.e. to microtubular 1
It is exactly with affected area aneurysm 6 for starting point to carry out effectively moulding section, is moulded to proximal part 2-5cm length along blood vessel 8
Shape.
Step S033, by the center point set obtained in step S032 according to O1-OnSequence pass sequentially through natural curve
Connection obtains curve ι1；Curve ι1The set of the geometric center point in numerous section theoretically on blood vessel 8, but it is based on above-mentioned institute
The value error stated and available accuracy requirement, the mode that interval value may be used obtain the song consistent with 8 form of real blood vessels
Line ι1In order to be rapidly performed by medicine modeling；It, usually can be by attending physician according to lesion blood vessel 8 in practical value
Bending degree determines the density of value, and value density is bigger, and medicine modeling is smaller with the construction distortion factor of actual vessel 8；It is on the contrary
It is as the same.Therefore, in carrying out medicine modeling process, attending physician can flexibly be built according to actual conditions and special requirement
Mould.
Step S034, with the curve ι obtained in step S0331On the basis of respectively scan that obtain outer diameter be 3.3mm-6mm
3D solid L2With the 3D solid L that outer diameter is 2.5mm-5mm3；Pass through 3D solid L2Subtract 3D solid L3Obtaining wall thickness is
The casing data packet B02 of 0.8mm-1.0mm；Casing data packet B02 is edited, is obtained according to the multiple notches of blood vessel curvature editor (5)
Casing model data packet C01.
It is worth noting that microtubular 1 is using the product of external import at present, diameter usually 0.3-1.8mm it
Between, it when casing inner diameter is this range of 2.5mm-5mm, can realize moulding to the steam of microtubular 1, difference lies in work as set
Bore be 2.5mm when, doctor carry out casing is moulding penetrate during can have certain difficulty, especially blood vessel moulding
Very lopsided, the very big abnormity construction of bending curvature is especially prominent, but advantage be it is moulding after precision it is high, with blood vessel
Compactness is very good；When casing inner diameter be 5mm when, doctor carry out casing is moulding penetrate during can very smoothly, in the short time
Interior to complete to intert, even if blood vessel moulding is very lopsided, the very big abnormity construction of bending curvature also can be smoothly by microtubular
1 is inserted into the moulding channel 2 of auxiliary brace 3 as shown in Figure 5, but disadvantage be it is moulding after precision first to relatively low, with blood
The compactness of pipe is relatively poor, during coping with the interventional embolization of some difficult cases, causes the probability of operation embolism difficulty
It can increase.
Existing microtubular 1 have Finecross microtubulars (1.8F, Terumo company), Progreat microtubulars (2.0F,
Terumo companies), To rnus microtubulars (2.1F, Asahi company), (1.2F-2.5F, Asahi are public for Co rsair microtubulars
Department), 2 microtubulars of Transit (2.3F, Co rdis companies), Excelsio r microtubulars (2.0F, Boston
Scientific companies), Crusade two-chambers microtubular (3.1F, Kaneka company) etc., wherein it is domestic the most commonly used is
Finecross, To rnus and co rsair microtubulars.
Wherein, by taking Finecross microtubulars as an example：It is that CTO lesions interventional treatment often uses instrument, is treated in positive PCI
In, the application of Finecross microtubulars is more convenient, cheap, and positioning becomes apparent from, and is used in 6F guiding catheters
Other intervention therapeutic apparatus can be compatible with when Finecross microtubulars.Braiding structure and the small feature of outer diameter make Finecross
Microtubular has some superiority in terms of passing through occlusion section lesion, is more used for positive PCI treatments.Finecross microtubulars
It is divided into 130cm, 150cm according to length, trailing end outer diameter 2.6F is integrally conical structure and is gradually reduced from tail end head-end,
Head end outer diameter is only 1.8F (0.6mm), and internal diameter is 0.4572mm (0.018 inch)；There are hydrophilic coating, chamber in head end outer surface
Inside there is polytetrafluoroethylene (PTFE) (PTFE) coating.Finecross microtubular bar portions are that stainless steel works out pigtail structure, can effectively be resisted
Kinking；Front end pyramidal structure, the hydrophilic coating of outer surface and minimum catheter opening outer diameter make it possess through Doppler flow mapping blood
The excellent ability of pipe and Occlusion, inner cavity are nylon polytetrafluorethylecoatings coatings, resistance to sliding of the seal wire in microtubular of driving in the wrong direction
Very little.
In order to avoid the above problem, the preferably described 3D solid L3Outer diameter be set as 3mm be it is best, as auxiliary branch
The internal diameter in the moulding channel 2 of tool 3 is 3mm；From the perspective of specific theoretical modeling, 3D solid L3Outer diameter be more than simultaneously
The outer diameter for being infinitely close to microtubular 1 is more accurate in terms of moulding constraint, and effectively moulding rear and disease is carried out to microtubular 1
The form of the actual focal blood vessel of trouble more matches；But in carrying out steam moulding process to microtubular 1, if microtubular 1 and set
The hollow channel and 3D solid L of tube model3Outer diameter be too close to, following operating barrier can be brought：One, doctor into
Before row microtubular 1 is moulding, need microtubular 1 being inserted into the moulding channel 2 by the molding brace ontology of 3D printing 3, this
When, the internal diameter in moulding channel 2 and the outer diameter of microtubular 1 get too close to directly result in doctor microtubular 1 is inserted into it is moulding
It is extremely difficult in channel 2, it is not easy to be inserted into；Secondly, carry out high-temperature steam it is stifling when, if between more than 2 microtubular 1 of moulding channel
Gap it is too small, steam can not adequately wrap up microtubular 1, and microtubular 1 can have uneven heating and occur moulding
Deformity, different from the form in moulding channel 2, compactness is not high and can not use.
If the internal diameter enlarged meeting in moulding channel 2 is improved directly and significantly microtubular 1 during high-temperature steam is stifling
Moulding efficiency.In general steam moulding process, the vapor (steam) temperature of use is between 92 ° -105 °, the time of steam fumigating modeling
About 4-8min, specific time can specifically determine according to the material difference of different microtubulars 1.This is for people in the art
Subjective judgement can be carried out for member or the attending physician of this field operation, if vapor (steam) temperature is too low or the steaming time
Secondary operation can not enough be carried out；This usually can flexibly be grasped, this link belongs to the prior art, in this embodiment
It does not repeat.
Embodiment 5：
As one of the preferred embodiment of the present invention, on the basis of above-described embodiment 4, in the calibration in step S031
Heart point OnMethod of determination include the following steps：
Step S0311, the arbitrary section chosen on the mathematical model blood vessel in step S031 is as rectangular coordinate system
In, and respectively by section it is extremely upper, extremely under, ultra-Left and ultra-Right four several points be demarcated as point E, point F, point G and point H respectively；
Step S0312, the extremely upper point E and extremely lower point F of connection, and find out the midpoint M of line segment EF；Connect ultra-Left point G and ultra-Right
Point H, and find out the midpoint N of line segment GH；MN is connected, and determines that the midpoint of line segment MN is the calibration central point O in the sectionn。
In the present embodiment, the selection quantity in multiple sections described in step S032 with the increase of corresponding blood vessel curvature and
Increase, and the vertical range between two neighboring section is no more than 1mm.
Embodiment 6：
A kind of aneurysm intervention operation moulding auxiliary brace of microtubular, as shown in Figure 5 and Figure 6, including brace ontology 3, institute
3 inside of brace ontology is stated with the moulding channel 2 being arranged along 3 length direction of brace ontology for accommodating microtubular 1, the branch
It is provided with the notches 5 of multiple hollow outs being connected to the moulding channel 2 on tool ontology 3, shape between the two neighboring notch 5
At a moulding ring 4 with the brace ontology 3 integrated molding for limiting the microtubular 1.
Operation principle：
Microtubular 1 in its natural state, is inserted into corresponding sufferer blood vessel and made by typically straightened condition by the end of microtubular 1
In the moulding channel 2 of the brace ontology 3 of type form, since microtubular 1 is by the constraint of the moulding ring 4 and brace ontology 3,
As moulding channel 2 occurs to be bent and deform accordingly under the effect of contraction of external force；Then by microtubular 1 and the brace
Ontology, which is put into steam stifling instrument, carries out thermoplastics type, and under the action of high-temperature steam, the internal stress of microtubular 1 gradually disappears
It loses, is bonded completely with moulding channel 2, then take out brace ontology 3 and microtubular 1 carries out cooling and shaping, remove branch after cooling
Have ontology 3 to complete to the moulding of microtubular 1, it is moulding after microtubular 1 it is as shown in Figure 1.It is worth noting that：Due to microtubular
1 is typically using external imported product, and the material and thermoplasticity of the microtubular 1 of different company's production have a certain difference, because
This, when carrying out moulding using different microtubulars 1, specific vapor (steam) temperature and steaming time set according to the specific conduit of use
Depending on fixed parameter, it cannot treat different things as the same；Classification about microtubular 1 is existing in example 4 to be discussed in detail, and is not done herein
It repeats.
Embodiment 7：
On the basis of the structure of embodiment 6 and principle, the moulding auxiliary brace of microtubular is made in order to take into account simultaneously
Cost, the material of quality and efficiency, the brace ontology 3 is by the powder sintered molding 3D printer sintering printings of SLS
Glass fibre or nylon powder.
In order to ensure microtubular 1 can preferably be bonded the brace ontology 3 in carrying out high temperature fumigation moulding process,
Acquisition and the natural curve form of moulding channel 2 always, are especially arranged using following preferred embodiments：The notch 5 is along brace sheet
The length in 3 axial length direction of body is 2-5 times of the length of moulding ring 4；The axial length of the moulding ring 4 is 1-4mm.
Further preferred, length of the notch 5 along 3 axial length direction of brace ontology is the length of moulding ring 4
3 times；The axial length of the moulding ring 4 is 2mm.
The outer diameter of the brace ontology 3 is 3.3mm-6mm, internal diameter 2.5mm-5mm；Wall thickness is the set of 0.8mm-1.0mm
Pipe data packet；Further preferred internal diameter is 3mm.Microtubular 1 is at present the product for using external import, though domestic have life
Production, but since quality is not sufficiently stable, clinic is using few.1 diameter of import microtubular works as casing usually between 0.3-1.8mm
It when internal diameter is this range of 2.5mm-5mm, can realize moulding to the steam of microtubular 1, difference lies in when casing inner diameter is
When 2.5mm, doctor carry out casing is moulding penetrate during can have certain difficulty, especially blood vessel moulding is very lopsided,
The very big abnormity construction of bending curvature is especially prominent, but advantage be it is moulding after precision it is high, it is non-with the compactness of blood vessel
Chang Hao；When casing inner diameter be 5mm when, doctor carry out casing is moulding penetrate during can very smoothly, in a short time can be complete
At interting, even if blood vessel moulding is very lopsided, microtubular 1 also can be smoothly inserted by the very big abnormity construction of bending curvature
In the moulding channel 2 of auxiliary brace 3 as shown in Figure 5, but disadvantage be it is moulding after precision first to relatively low, the patch with blood vessel
It is right relatively poor, during coping with the interventional embolization of some difficult cases, cause the probability of operation embolism difficulty that can increase
Add.
Embodiment 8：
The present embodiment disclose it is a kind of using brace ontology 3 described in above-described embodiment 7 carry out it is moulding with obtain with sufferer disease
The method of the microtubular 1 of blood vessel moulding at stove.Specifically include the following contents：
The piercing portion end that will be ready for the microtubular 1 of operation is inserted into from the distal end of the brace ontology 3, and will
The end of microtubular 1 is deep into aneurysm；Then microtubular 1 and the brace ontology 3 being set on the microtubular 1 is whole
Body, which is put into steaming instrument, carries out high temperature fumigation；Fumigation temperature is preferably controlled to 85 DEG C -95 DEG C, is used in the present embodiment,
The Finecross microtubulars of Terumo companies, 1.8F.Herein, it should be noted that if moulded using other microtubulars 1
Shape, abovementioned steps are identical, but should adjust corresponding moulding temperature according to the specification and thermoplasticity of the microtubular 1 of different company
Degree.
It after being placed on stifling instrument, should check whether the end of microtubular 1 has been deep into aneurysm, and seal smoked
Instrument is steamed to be fumigated；When temperature rise is to after 80 DEG C, timing closes stifling instrument in 5 minutes, is cooled down rapidly.Gently
Microtubular 1 after will be moulding is released from the brace ontology 3, and the shape of microtubular 1 and brace ontology 3 is carried out
Comparison, checks moulding effect, if there are moulding unevenness, the 1 incomplete situation of part internal stresses release of microtubular；If moulding
Intact, then the operation that can carry out disinfection is spare；If there are notable differences for partial mold, the reality of stifling instrument should be checked in time
It whether there is since channel caused by the laminated striation of 3D printing is narrow in temperature and brace ontology 3, cause steam abundant
It reaches and carries out hot transmission；After inspection, above-mentioned steaming step is being repeated, until moulding meet the requirements.
Microtubular 1 is inserted into blood vessel by the wound of operation at the time of surgery, is slowly rotated by surgeon
Microtubular 1 is simultaneously gradually inserted in the aneurysm for the affected area that goes directly in blood vessel, finally passes through microtubular 1 in the way of existing
Dedicated embolism spring ring is sent in aneurysm, microtubular is extracted.
The present invention is not limited to above-mentioned optional embodiment, anyone can obtain other under the inspiration of the present invention
Various forms of products.Above-mentioned specific implementation mode should not be understood the limitation of pairs of protection scope of the present invention, guarantor of the invention
Shield range should be subject to be defined in claims, and specification can be used for interpreting the claims.
Claims (10)
1. a kind of aneurysm intervention operation moulding auxiliary brace of microtubular, it is characterised in that：Including brace ontology (3), the branch
Have the moulding channel (2) having inside ontology (3) along the setting of brace ontology (3) length direction for accommodating microtubular (1), it is described
The notch (5) of multiple hollow outs being connected to the moulding channel (2), the two neighboring notch are provided on brace ontology (3)
(5) a moulding ring (4) being integrally formed with the brace ontology (3) for limiting the microtubular (1) is formed between.
2. a kind of aneurysm intervention operation moulding auxiliary brace of microtubular according to claim 1, it is characterised in that：It is described
The material of brace ontology (3) is the glass fibre or nylon powder by powder sintered molding printing；The sinter molding is beaten
The mode of print includes using the powder sintered molding 3D printers of SLS or MJF sinter molding equipment.
3. a kind of aneurysm intervention operation moulding auxiliary brace of microtubular according to claim 2, it is characterised in that：It is described
Length of the notch (5) along brace ontology (3) axial length direction is 2-5 times of the length of moulding ring (4)；The moulding ring (4)
Axial length be 1-4mm.
4. a kind of aneurysm intervention operation moulding auxiliary brace of microtubular according to claim 3, it is characterised in that：It is described
Length of the notch (5) along brace ontology (3) axial length direction is 3 times of the length of moulding ring (4)；The moulding ring (4)
Axial length is 2mm.
5. the production method of the moulding auxiliary brace of a kind of aneurysm intervention operation microtubular, for utilizing steam to intervening the cerebrovascular
Microtubular carry out it is quickly moulding, with obtain the microtubular adaptable with focal arterial tumor and shape of blood vessel and intervene aneurysm into
Row Treatment of Endovascular Embolization；It is characterized in that：The making of the moulding auxiliary brace of microtubular specifically includes following steps：
Step S01 obtains lesion blood vessel and aneurysmal CT images data packet A01, this step institute using CT angiography scans
State A01 can also be using including obtaining by the way of CTA, MRA, DSA；
The CT images data packet A01 that step S01 is obtained is imported the medicine that can recognize that the CT images data packet A01 by step S02
Modeling software simultaneously obtains 3D mathematical model data packets corresponding with A01 parameters and to be preserved including CAD or STL general formats
B01；
Step S03, the 3D mathematical model data packets B01 that step S02 is obtained obtain shape and the 3D mathematics into edlin
Model data packet B01 is consistent, and editor's 3D mathematical model data packets B01 obtains the casing data packet B02 of inner hollow；Edit casing
Data packet B02 obtains the casing model data packet C01 with multiple notches (5) being in communication with the outside；
The described sleeve pipe model data packet C01 obtained in step S03 is imported and is used the powder sintered molding 3D of SLS by step S04
3D printing is carried out in printer obtains the auxiliary brace moulding for aneurysm intervention operation microtubular.
6. the production method of the moulding auxiliary brace of aneurysm intervention operation microtubular according to claim 5, feature exist
In：The contrast agent that CT angiographies use described in step S01 is iodine reagent or carbon dioxide as contrast agent；Angiography
Operating procedure be：It will be while contrast agent injection patient's body or at once using the increasing of CT radiographies by the way of intravenous injection
Strong scanning or plain CT, which are scanned lesions position, obtains CT images data packet A01.
7. the production method of the moulding auxiliary brace of aneurysm intervention operation microtubular according to claim 5 or 6, feature
It is：Medical science modeling software described in step S02 is Mimics, 3DSlicer or Arigin3D.
8. the production method of the moulding auxiliary brace of aneurysm intervention operation microtubular according to claim 7, feature exist
In：The casing model data packet C01 that inner hollow is obtained in step S03 includes the following steps：
Step S031 determines the mark of the arbitrary section on the mathematical model length of vessel direction in 3D mathematical model data packets B01
Centre mark On；
Step S032 obtains the length field that aneurysm in 3D mathematical model data packets B01 extends 2cm-5cm along blood vessel to proximal part
Between on multiple sections calibration central point O1-On；
Step S033, by the center point set obtained in step S032 according to O1-OnSequence pass sequentially through natural curve connection obtain
Obtain curve ι1；
Step S034, with the curve ι obtained in step S0331On the basis of scan that obtain the three-dimensional that outer diameter is 3.3mm-6mm real respectively
Body L2With the 3D solid L that outer diameter is 2.5mm-5mm3；Pass through 3D solid L2Subtract 3D solid L3Acquisition wall thickness is 0.8mm-
The casing data packet B02 of 1.0mm；Casing data packet B02 is edited, set pipe die is obtained according to the multiple notches of blood vessel curvature editor (5)
Type data packet C01.
9. the production method of the moulding auxiliary brace of aneurysm intervention operation microtubular according to claim 8, feature exist
In：Calibration central point O in step S031nMethod of determination include the following steps：
Step S0311, the arbitrary section chosen on the mathematical model blood vessel in step S031 as in rectangular coordinate system, and point
Not by section it is extremely upper, extremely under, ultra-Left and ultra-Right four several points be demarcated as point E, point F, point G and point H respectively；
Step S0312, the extremely upper point E and extremely lower point F of connection, and find out the midpoint M of line segment EF；Ultra-Left point G and ultra-Right point H are connected,
And find out the midpoint N of line segment GH；MN is connected, and determines that the midpoint of line segment MN is the calibration central point O in the sectionn。
10. the production method of the moulding auxiliary brace of aneurysm intervention operation microtubular according to claim 8, feature exist
In：The selection quantity in multiple sections described in step S032 increases with the increase of corresponding blood vessel curvature, and two neighboring section
Vertical range between face is no more than 1mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810559232.9A CN108478918A (en) | 2018-06-01 | 2018-06-01 | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810559232.9A CN108478918A (en) | 2018-06-01 | 2018-06-01 | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108478918A true CN108478918A (en) | 2018-09-04 |
Family
ID=63341834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810559232.9A Pending CN108478918A (en) | 2018-06-01 | 2018-06-01 | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108478918A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110288693A (en) * | 2019-06-06 | 2019-09-27 | 昆明医科大学第二附属医院 | A kind of intelligent microtubular Shaping System of intracranial aneurysm intervention operation |
| CN111330135A (en) * | 2020-03-04 | 2020-06-26 | 中国人民解放军总医院第六医学中心 | Aneurysm interventional operation micro-catheter shaping auxiliary support and manufacturing method thereof |
| CN114788919A (en) * | 2022-03-09 | 2022-07-26 | 北京柯莱文科技咨询有限公司 | Aneurysm interventional operation micro-catheter shaping auxiliary die and manufacturing method thereof |
| CN115192855A (en) * | 2022-07-13 | 2022-10-18 | 适介医疗科技(广州)有限公司 | Conduit shaping device and shaping assembly |
| CN116524003A (en) * | 2023-06-26 | 2023-08-01 | 杭州脉流科技有限公司 | Method and device for obtaining morphological parameters of bifurcation aneurysm |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6863856B1 (en) * | 2002-12-30 | 2005-03-08 | Advanced Cardiovascular Systems, Inc. | Slotted mold for making a catheter balloon |
| CN201645815U (en) * | 2010-04-30 | 2010-11-24 | 陈光辉 | Intervened conduit shaping module |
| CN106037853A (en) * | 2016-05-04 | 2016-10-26 | 李泽福 | Microcatheter moulding stent used for intracranial aneurysm embolization and preparation method of microcatheter moulding stent |
| CN107392872A (en) * | 2017-07-27 | 2017-11-24 | 强联智创（北京）科技有限公司 | The generation method and generation system of a kind of microtubular shaping device |
| JP2017217392A (en) * | 2016-06-10 | 2017-12-14 | メディカル・イノベイション株式会社 | Shape imparting tool |
| CN107468334A (en) * | 2017-08-01 | 2017-12-15 | 强联智创（北京）科技有限公司 | A kind of moulding aided design system of three-dimensional microtubular and design method |
| CN206946482U (en) * | 2017-07-26 | 2018-01-30 | 强联智创（北京）科技有限公司 | A kind of aided design system of microtubular shaping device |
| CN207928564U (en) * | 2018-06-01 | 2018-10-02 | 成都真实维度科技有限公司 | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular |
-
2018
- 2018-06-01 CN CN201810559232.9A patent/CN108478918A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6863856B1 (en) * | 2002-12-30 | 2005-03-08 | Advanced Cardiovascular Systems, Inc. | Slotted mold for making a catheter balloon |
| CN201645815U (en) * | 2010-04-30 | 2010-11-24 | 陈光辉 | Intervened conduit shaping module |
| CN106037853A (en) * | 2016-05-04 | 2016-10-26 | 李泽福 | Microcatheter moulding stent used for intracranial aneurysm embolization and preparation method of microcatheter moulding stent |
| JP2017217392A (en) * | 2016-06-10 | 2017-12-14 | メディカル・イノベイション株式会社 | Shape imparting tool |
| CN206946482U (en) * | 2017-07-26 | 2018-01-30 | 强联智创（北京）科技有限公司 | A kind of aided design system of microtubular shaping device |
| CN107392872A (en) * | 2017-07-27 | 2017-11-24 | 强联智创（北京）科技有限公司 | The generation method and generation system of a kind of microtubular shaping device |
| CN107468334A (en) * | 2017-08-01 | 2017-12-15 | 强联智创（北京）科技有限公司 | A kind of moulding aided design system of three-dimensional microtubular and design method |
| CN207928564U (en) * | 2018-06-01 | 2018-10-02 | 成都真实维度科技有限公司 | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110288693A (en) * | 2019-06-06 | 2019-09-27 | 昆明医科大学第二附属医院 | A kind of intelligent microtubular Shaping System of intracranial aneurysm intervention operation |
| CN111330135A (en) * | 2020-03-04 | 2020-06-26 | 中国人民解放军总医院第六医学中心 | Aneurysm interventional operation micro-catheter shaping auxiliary support and manufacturing method thereof |
| CN111330135B (en) * | 2020-03-04 | 2022-02-22 | 中国人民解放军总医院第六医学中心 | Aneurysm interventional operation micro-catheter shaping auxiliary support and manufacturing method thereof |
| CN114788919A (en) * | 2022-03-09 | 2022-07-26 | 北京柯莱文科技咨询有限公司 | Aneurysm interventional operation micro-catheter shaping auxiliary die and manufacturing method thereof |
| CN114788919B (en) * | 2022-03-09 | 2023-12-08 | 北京柯莱文科技咨询有限公司 | Microcatheter moulding auxiliary mould for aneurysm intervention operation and manufacturing method thereof |
| CN115192855A (en) * | 2022-07-13 | 2022-10-18 | 适介医疗科技(广州)有限公司 | Conduit shaping device and shaping assembly |
| CN116524003A (en) * | 2023-06-26 | 2023-08-01 | 杭州脉流科技有限公司 | Method and device for obtaining morphological parameters of bifurcation aneurysm |
| CN116524003B (en) * | 2023-06-26 | 2023-09-12 | 杭州脉流科技有限公司 | Method and device for obtaining morphological parameters of bifurcation aneurysm |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108478918A (en) | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular and preparation method thereof | |
| US20210187856A1 (en) | Fenestration template for endovascular repair of aortic aneurysms | |
| CN207928564U (en) | A kind of aneurysm intervention operation moulding auxiliary brace of microtubular | |
| JP6455946B2 (en) | System and method for making a custom medical implant device | |
| CN106110469B (en) | Conduit device | |
| CN104545880B (en) | Patient-specific pre-shaped cardiac catheter | |
| US7813785B2 (en) | Cardiac imaging system and method for planning minimally invasive direct coronary artery bypass surgery | |
| Robinson et al. | Patient-specific design of a soft occluder for the left atrial appendage | |
| DE102004020171A1 (en) | Cardiological CT system and method for planning left atrial ear isolation | |
| JP2024020483A (en) | Speed determination for intraluminal ultrasound imaging and associated devices, systems, and methods | |
| CN110248603A (en) | 3D ultrasound and computer tomography are combined for guiding intervention medical protocol | |
| JP2010508910A (en) | Devices and methods for accessing and treating aneurysms | |
| CN107049484A (en) | Intracranial aneurysm 3D model Method of printings based on DSA data | |
| Seong et al. | Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas | |
| Rossitti et al. | 3D road-mapping in the endovascular treatment of cerebral aneurysms and arteriovenous malformations | |
| CN208943185U (en) | A kind of microtubular moulding auxiliary device of 3D printing | |
| CN108685600B (en) | Full-false cavity controllable blood flow blocking device and manufacturing method thereof | |
| Leal et al. | Three-dimensional hollow elastic models for intracranial aneurysm clipping election–a case study | |
| CN208145032U (en) | It is implanted into the device of the abnormal swelling part of ductus arteriosus wall | |
| CN114723844A (en) | Method, system and equipment for reconstructing pulsatile perfusion image corrected by saline contrast | |
| US20180055379A1 (en) | X-ray recording with superimposed planning information | |
| CN107007316A (en) | It is implanted into the device of the abnormal swelling part of ductus arteriosus wall | |
| CN114788919B (en) | Microcatheter moulding auxiliary mould for aneurysm intervention operation and manufacturing method thereof | |
| RU2600282C2 (en) | Method of anatomical sublobular pulmonary resections scheduling in patients with peripheral volumetric formations based on ct-pulmonary angiography | |
| Shee et al. | Personalized Fluoroscopic Angles in Watchman™ Left Atrial Appendage Closure Landing Zone Assessment: A Three-Dimensional Printed Simulation Study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 610000 No.804, floor 8, unit 1, building 6, Zone D, West Zhigu, No.166, Wuxing Fourth Road, Wuhou New Town Management Committee, Wuhou District, Chengdu City, Sichuan Province Applicant after: Chengdu real dimension Technology Co., Ltd. Address before: 610000 No. 801, Building 8, Building 6, Unit 1, West Zhigu D District, 166 Wuxing Road, Wuhou New Town Management Committee, Chengdu, Sichuan Province Applicant before: Chengdu real dimension Technology Co., Ltd. |
|
| CB02 | Change of applicant information |