CN108478522A - A kind of draft nursing gel with sterilization repair - Google Patents
A kind of draft nursing gel with sterilization repair Download PDFInfo
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- CN108478522A CN108478522A CN201810475543.7A CN201810475543A CN108478522A CN 108478522 A CN108478522 A CN 108478522A CN 201810475543 A CN201810475543 A CN 201810475543A CN 108478522 A CN108478522 A CN 108478522A
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention discloses feminine hygiene articles technical field, specific field is a kind of draft nursing gel with sterilization repair, and raw material group becomes：Aloe, oat beta-glucan aqueous solution, glycerine, transparent xanthan gum, hyaluronic acid, propylene glycol, 1, 3 butanediols, agalloch eaglewood, acetic acid chlorhexidine solution, Phenoxyethanol, remaining is purified water, aloe and oat beta-glucan aqueous solution have stronger repair to skin, the oat beta-glucan in oat is extracted using the method for ultrasonic wave extraction, prepare oat beta-glucan aqueous solution, oat beta-glucan has unique straight-chain molecular structure, with good Transdermal absorption performance, it is easy to be less readily available for absorption by the skin, fibrocyte is promoted to synthesize collagen, there is stronger repair to skin, aloe has both sterilization and repair, the present invention is matched using aloe with oat beta-glucan aqueous solution, so that the basis sterilization and repair of draft nursing gel are effectively ensured.
Description
Technical field
The present invention relates to feminine hygiene articles technical field, specific field is a kind of draft shield with sterilization repair
Manage gel.
Background technology
Vagina flora is complex, and microorganism therein is divided into pathologic and commensalism in turn, various microorganisms it
Between be grown in same environment, there may be anti-effect short of money between each microorganism, when pH value is 3.8~4.2, is conducive to altogether
The dwell breeding of bacterium, especially Bacillus acidi lactici can inhibit harmful microorganism breeding to ensure the important strain of vaginal health, cloudy
It is restricted each other between road flora, inhibits pathologic bacterial action, but once balance is destroyed, intravaginal pH value is not suitable for lactic acid bar
Bacterium grows, and Bacillus acidi lactici is lost ground, and pathologic bacterial reproduction then will appear symptom, and existing private parts cleaning supplies generally have
There is bactericidal effect, but the cleaning supplies such as the soaps with bactericidal effect or liquid can make genital skin constantly by certain irritation
Effect, and the skin of external genital and mucous membrane is caused to become sensitive, skin disease easily occurs, is absorbed in vicious circle, therefore to warp
It after private parts sterilization, is repaired, to ensure female private part health, therefore proposes a kind of draft with sterilization repair
Nursing gel.
Invention content
The purpose of the present invention is to provide a kind of draft nursing gels with sterilization repair, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions：A kind of draft nursing with sterilization repair
Gel, raw material composition and corresponding weight percent are：It is aloe 9%~14%, oat beta-glucan aqueous solution 5%~8%, sweet
Oil 4%~8%, transparent xanthan gum 4%~7%, hyaluronic acid 3%~5%, propylene glycol 2%~4%, 1,3- butanediols 2%~
3%, agalloch eaglewood 1%~3%, acetic acid chlorhexidine solution 0.2%~0.6%, Phenoxyethanol 0.1%~0.2%, remaining for purifying
Water.
Preferably, the mass fraction of the acetic acid chlorhexidine solution is 0.02%~0.05%.
Preferably, the preparation method of the oat beta-glucan aqueous solution is：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：13~16, it is 50~60 DEG C in temperature
Under the conditions of mixed liquor is extracted using ultrasonic extraction, ultrasonic wave extraction frequency be 10~15kHz, extraction time 12
~20min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 1~5 DEG C in temperature.
Preferably, a kind of draft nursing gel with sterilization repair, preparation method are：
1) it is dried after cleaning aloe and agalloch eaglewood, is added in pulverizer and crushes, it is 20~30 mesh to be crushed to grain size,
Then the mixed-powder after crushing is added in purified water, it is spare；
2) glycerine, hyaluronic acid, propylene glycol and 1,3- butanediols are added in step 1) prepared product, are stirred, stirred
It is 20~30r/min to mix rate, and mixing time is 20~30min；
3) oat beta-glucan aqueous solution, acetic acid chlorhexidine solution and Phenoxyethanol are added in step 2) prepared product, into
Row stirring, stir speed (S.S.) are 30~40r/min, and mixing time is 20~30min；
4) transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) is 15~20r/min, stirring
Time is 40~50min, and it is in gel to make mixed liquor.
The beneficial effects of the invention are as follows：A kind of draft nursing gel with sterilization repair, aloe and oat Portugal are poly-
Sugar aqueous solution has stronger repair to skin, is carried the oat beta-glucan in oat using the method for ultrasonic wave extraction
It takes out, prepares oat beta-glucan aqueous solution, oat beta-glucan has unique straight-chain molecular structure, has good transdermal suction
Performance is received, is easy to be less readily available for absorption by the skin, fibrocyte is promoted to synthesize collagen, there is stronger repair, aloe to skin
Sterilization and repair are had both, is to commonly use one of substance in skin care item, the present invention is using aloe and the water-soluble liquid phase of oat beta-glucan
Cooperation so that the basis sterilization and repair of draft nursing gel are effectively ensured, and glycerine and hyaluronic acid are to private parts skin
There is skin lubrication and protective effect, acetic acid chlorhexidine solution to play the role of assisting sterilisation, transparent xanthan gum, propylene glycol, 1,3- fourths
Glycol and Phenoxyethanol play dissolving and gelatification to other substances, and it is in gel to make draft nursing gel.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment 1：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：13, make under the conditions of temperature is 50 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 10kHz, extraction time 12min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 1 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 9% aloe and 1% agalloch eaglewood, is added in pulverizer and crushes, it is 20 to be crushed to grain size
Then mixed-powder after crushing is added in 69.7% purified water by mesh, spare；
2) 4% glycerine, 3% hyaluronic acid, 2% propylene glycol and 2%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 20r/min, mixing time 20min；
3) 5% oat beta-glucan aqueous solution, 0.2% acetic acid chlorhexidine solution and 0.1% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 30r/min, mixing time 20min；
4) 4% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 15r/min, when stirring
Between be 40min, make mixed liquor be in gel.
Embodiment 2：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：13, make under the conditions of temperature is 52 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 11kHz, extraction time 14min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 1 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 10% aloe and 1% agalloch eaglewood, is added in pulverizer and crushes, it is 22 to be crushed to grain size
Then mixed-powder after crushing is added in 67.6% purified water by mesh, spare；
2) 5% glycerine, 3% hyaluronic acid, 2% propylene glycol and 2%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 22r/min, mixing time 22min；
3) 5% oat beta-glucan aqueous solution, 0.3% acetic acid chlorhexidine solution and 0.1% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 32r/min, mixing time 22min；
4) 4% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 16r/min, when stirring
Between be 42min, make mixed liquor be in gel.
Embodiment 3：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：14, make under the conditions of temperature is 54 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 12kHz, extraction time 15min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 2 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 11% aloe and 2% agalloch eaglewood, is added in pulverizer and crushes, it is 24 to be crushed to grain size
Then mixed-powder after crushing is added in 60.5% purified water by mesh, spare；
2) 6% glycerine, 4% hyaluronic acid, 3% propylene glycol and 2%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 24r/min, mixing time 24min；
3) 6% oat beta-glucan aqueous solution, 0.4% acetic acid chlorhexidine solution and 0.1% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 34r/min, mixing time 24min；
4) 5% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 17r/min, when stirring
Between be 44min, make mixed liquor be in gel.
Embodiment 4：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：15, make under the conditions of temperature is 56 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 13kHz, extraction time 17min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 3 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 12% aloe and 2% agalloch eaglewood, is added in pulverizer and crushes, it is 26 to be crushed to grain size
Then mixed-powder after crushing is added in 57.3% purified water by mesh, spare；
2) 7% glycerine, 4% hyaluronic acid, 3% propylene glycol and 3%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 26r/min, mixing time 26min；
3) 6% oat beta-glucan aqueous solution, 0.5% acetic acid chlorhexidine solution and 0.2% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 36r/min, mixing time 26min；
4) 5% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 18r/min, when stirring
Between be 46min, make mixed liquor be in gel.
Embodiment 5：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：16, make under the conditions of temperature is 58 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 14kHz, extraction time 18min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 4 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 13% aloe and 3% agalloch eaglewood, is added in pulverizer and crushes, it is 28 to be crushed to grain size
Then mixed-powder after crushing is added in 50.2% purified water by mesh, spare；
2) 8% glycerine, 5% hyaluronic acid, 4% propylene glycol and 3%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 28r/min, mixing time 28min；
3) 7% oat beta-glucan aqueous solution, 0.6% acetic acid chlorhexidine solution and 0.2% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 38r/min, mixing time 28min；
4) 6% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 19r/min, when stirring
Between be 48min, make mixed liquor be in gel.
Embodiment 6：
Oat beta-glucan aqueous solution is prepared first：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：16, make under the conditions of temperature is 60 DEG C
Mixed liquor is extracted with ultrasonic extraction, ultrasonic wave extraction frequency is 15kHz, extraction time 20min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, is obtained
Oat beta-glucan aqueous solution, stored under refrigeration at being 5 DEG C in temperature.
Then a kind of draft nursing gel with sterilization repair is prepared：
1) it is dried after cleaning 14% aloe and 3% agalloch eaglewood, is added in pulverizer and crushes, it is 30 to be crushed to grain size
Then mixed-powder after crushing is added in 47.2% purified water by mesh, spare；
2) 8% glycerine, 5% hyaluronic acid, 4% propylene glycol and 3%1,3- butanediols are added in step 1) prepared product,
It is stirred, stir speed (S.S.) 30r/min, mixing time 30min；
3) 8% oat beta-glucan aqueous solution, 0.6% acetic acid chlorhexidine solution and 0.2% Phenoxyethanol are added to step
2) it in prepared product, is stirred, stir speed (S.S.) 40r/min, mixing time 30min；
4) 7% transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) 20r/min, when stirring
Between be 50min, make mixed liquor be in gel.
A kind of draft with sterilization repair that 70 subjects use Examples 1 to 6 to prepare respectively is invited to nurse
As a comparison case with cleaning supplies, frequency of use is 1 time a day, to be used continuously one week, usage record for gel and existing private parts
It is as a result as follows,
As seen from the experiment, the present invention is a kind of has the draft nursing gel of sterilization repair in contrast to existing private parts
With cleaning supplies, there is stronger repair, pudendum part skin and mucous membrane can be made to moisten, is smooth, sensitive place is effectively delayed
Solution and reparation.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of draft nursing gel with sterilization repair, it is characterised in that：Its raw material forms and corresponding weight hundred
Point ratio is：Aloe 9%~14%, oat beta-glucan aqueous solution 5%~8%, glycerine 4%~8%, transparent xanthan gum 4%~
7%, hyaluronic acid 3%~5%, propylene glycol 2%~4%, 1,3- butanediols 2%~3%, agalloch eaglewood 1%~3%, acetic acid chlorine has been
Determine solution 0.2%~0.6%, Phenoxyethanol 0.1%~0.2%, remaining be purified water.
2. a kind of draft nursing gel with sterilization repair according to claim 1, it is characterised in that：The vinegar
The mass fraction of sour chlorhexidine solution is 0.02%~0.05%.
3. a kind of draft nursing gel with sterilization repair according to claim 1, it is characterised in that：The swallow
The preparation method of wheat glucan aqueous solution is：
1) oat is added in distilled water, the mass ratio of oat and distilled water is 1：13~16, it is 50~60 DEG C of conditions in temperature
Lower to be extracted to mixed liquor using ultrasonic extraction, ultrasonic wave extraction frequency is 10~15kHz, extraction time is 12~
20min；
2) extracting solution prepared in step 1) is filtered, filtered fluid is concentrated into the 1/3 of original volume after filtering, obtains oat
Glucan aqueous solution, stored under refrigeration at being 1~5 DEG C in temperature.
4. a kind of draft nursing gel with sterilization repair according to claim 1, it is characterised in that：It is prepared
Method is：
1) it is dried after cleaning aloe and agalloch eaglewood, is added in pulverizer and crushes, it is 20~30 mesh to be crushed to grain size, then
Mixed-powder after crushing is added in purified water, it is spare；
2) glycerine, hyaluronic acid, propylene glycol and 1,3- butanediols are added in step 1) prepared product, are stirred, stirring speed
Rate is 20~30r/min, and mixing time is 20~30min；
3) oat beta-glucan aqueous solution, acetic acid chlorhexidine solution and Phenoxyethanol are added in step 2) prepared product, are stirred
It mixes, stir speed (S.S.) is 30~40r/min, and mixing time is 20~30min；
4) transparent xanthan gum is added into step 3) prepared product, is stirred, stir speed (S.S.) is 15~20r/min, mixing time
For 40~50min, it is in gel to make mixed liquor.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810475543.7A CN108478522A (en) | 2018-05-17 | 2018-05-17 | A kind of draft nursing gel with sterilization repair |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810475543.7A CN108478522A (en) | 2018-05-17 | 2018-05-17 | A kind of draft nursing gel with sterilization repair |
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| CN108478522A true CN108478522A (en) | 2018-09-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111434334A (en) * | 2019-01-11 | 2020-07-21 | 李可 | Female gel |
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| CN104940122A (en) * | 2015-07-13 | 2015-09-30 | 云南白药清逸堂实业有限公司 | No-wash type female care solution and preparation method thereof |
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2018
- 2018-05-17 CN CN201810475543.7A patent/CN108478522A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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