CN108465157A - A kind of graphene hair follicle physiotherapeutic needle - Google Patents
A kind of graphene hair follicle physiotherapeutic needle Download PDFInfo
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- CN108465157A CN108465157A CN201810237282.5A CN201810237282A CN108465157A CN 108465157 A CN108465157 A CN 108465157A CN 201810237282 A CN201810237282 A CN 201810237282A CN 108465157 A CN108465157 A CN 108465157A
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- hair follicle
- point structure
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- 210000003780 hair follicle Anatomy 0.000 title claims abstract description 62
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 229910021389 graphene Inorganic materials 0.000 title claims abstract description 56
- 238000007789 sealing Methods 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 15
- 230000010355 oscillation Effects 0.000 claims abstract description 10
- 230000004936 stimulating effect Effects 0.000 claims abstract description 5
- 230000008021 deposition Effects 0.000 claims abstract description 3
- 238000002484 cyclic voltammetry Methods 0.000 claims description 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 12
- 238000005498 polishing Methods 0.000 claims description 12
- 238000004140 cleaning Methods 0.000 claims description 6
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical class Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229910052697 platinum Inorganic materials 0.000 claims description 6
- 238000007711 solidification Methods 0.000 claims description 6
- 230000008023 solidification Effects 0.000 claims description 6
- 239000012498 ultrapure water Substances 0.000 claims description 6
- 238000002604 ultrasonography Methods 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 239000003643 water by type Substances 0.000 claims description 6
- 210000000481 breast Anatomy 0.000 claims description 2
- 229910002804 graphite Inorganic materials 0.000 claims description 2
- 239000010439 graphite Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000012295 chemical reaction liquid Substances 0.000 claims 1
- -1 graphite alkene Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 230000004048 modification Effects 0.000 abstract description 6
- 238000012986 modification Methods 0.000 abstract description 6
- 206010003694 Atrophy Diseases 0.000 abstract description 5
- 230000037444 atrophy Effects 0.000 abstract description 5
- 230000003779 hair growth Effects 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 238000010960 commercial process Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000004761 scalp Anatomy 0.000 abstract 1
- 238000000554 physical therapy Methods 0.000 description 19
- 210000004209 hair Anatomy 0.000 description 15
- 201000004384 Alopecia Diseases 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 231100000360 alopecia Toxicity 0.000 description 7
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000018380 Chemical injury Diseases 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 230000003646 hair health Effects 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 235000020825 overweight Nutrition 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
- A61N5/0617—Hair treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
- A61M2205/052—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
- A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared
Abstract
The invention discloses a kind of graphene hair follicle physiotherapeutic needles,Including needle body,It is internally provided with oscillation power and impulse generator in needle body,The outside of needle body is sealing shell,It is needle point structure in the bottom end of sealing shell,The top of needle point structure is needle handle,Needle point structure is inserted into the inside of sealing shell by the needle handle above it,The lower half portion of needle point structure is set to the outside of sealing shell,Needle point structure surface deposition has one layer of fine and close graphene film layer,Graphene film layer launches 8 15 microns of far infrared waves after being powered,So as to human body cell under hair follicle stimulating,Invention additionally discloses a kind of method of modifying of needle point structure,It can be quickly in the grapheme modified layer of the surface batch of physiotherapeutic needle,And it being capable of effective controlled modification thickness,Suitable for commercial process,The graphene hair follicle physiotherapeutic needle can effectively prevent hair follicle atrophy,It promotes blood circulation,Promote hair growth,Pass through physiotherapeutic needle hair follicle stimulating,Effectively enhancing scalp comfort level.
Description
Technical field
The present invention relates to a kind of physiotherapeutic needle, specially a kind of graphene hair follicle physiotherapeutic needle.
Background technology
Hair follicle is the bourse for being enclosed in root of hair, and internal layer is epithelial tissue hair follicle, and outer layer is connective tissue
Hair follicle, internal layer are connected with epidermis, and outer layer is then connected with corium, and people cannot grow new hair follicle, and hair follicle is the skin for enabling hair growth
Skin cell.All hair follicles are born together with people, and are unrenewable, the hair of hair follicle after hair follicle death with all one's life of people
It educates by the interaction of a series of complex between epidermis and corium and is formed, and with periodically.
It will appear anxiety and uneasiness after oneself alopecia of many Finding cases, or even will appear the phenomenon that turning to any doctor one can find when critically ill, tie
Not only fruit cannot alleviate alopecia symptom, instead can be increasingly severe, and the health of hair follicle, which is only, in fact determines that can hair health life
Long key, when there is the symptom of alopecia, greatly the reason is that caused by atrophy and closure due to hair follicle, positive reason
Under condition, hair, which has, to be fallen, this is to belong to metabolic phenomena, daily hair loss amount is more than 100, and continue for
At three months as long as, then this situation will need to arouse attention, it is likely that be exactly alopecia, and main cause is probably
It is hair follicle atrophy, it is exactly actually the final result of hair follicle atrophy development of leaving that hair follicle, which is closed, and hair follicle loses vitality completely how
Redemption also is difficult to " coming back to life ".The main method for the maintenance of hair follicle is exactly by drug treatment, in drug treatment at present
During, although alleviating the process of alopecia in certain degree, drug also brings along chemical injury, nothing simultaneously
Method reaches permanent maintenance processes.
Therefore, how physiotherapy products are improved, make it overcome disadvantages mentioned above that can have the advantages that again certain, is ability
A field technique personnel problem urgently to be resolved hurrily.
Invention content
The main purpose of the present invention is to provide one kind to be used conveniently and safely, by physiotherapeutic needle physical therapy, physiotherapeutic needle needle point
Graphene film layer releases infrared ray, the graphene breast hair follicle for allowing the patient of the even permanent alopecia of serious alopecia to be cured as early as possible
The method of modifying of physiotherapeutic needle and its needle point structure.
To achieve the above objectives, the technical solution adopted by the present invention is：A kind of graphene hair follicle physiotherapeutic needle, including needle body,
It is internally provided with oscillation power and impulse generator in the needle body, the outside of the needle body is sealing shell, the oscillation
Power supply and the impulse generator fixed in position are needle point knot in the bottom end of the sealing shell in the inside of the sealing shell
The top of structure, the needle point structure is needle handle, and the needle point structure is inserted into the sealing shell by the needle handle above it
Inside, the lower half portion of the needle point structure is set to the outside of the sealing shell, and the needle point structure surface deposition has
One layer of fine and close graphene film layer, the graphene film layer launches 8-15 microns of far infrared waves after being powered, so as to hair follicle stimulating
Lower human body cell.
It is hollow structure in the inside of the handle, in sky as an improvement, being equipped with handle on the left of the sealing shell
The handle inner of the heart is mounted with electrified wire, so that the oscillation power is connected with external power supply.
As an improvement, being equipped with rotation axis between the handle and the sealing shell, institute is realized by the rotation axis
The rotation between handle and the sealing shell is stated, when on the shelf, in parallel between the handle and the sealing shell
Receiving state, in use, positioned vertical between the handle and the sealing shell.
As an improvement, the top of the needle body is pulse regulation knob, the pulse regulation knob and the pulse generation
Device is connected with each other, and adjusts what impulse generator was sent out by rotating clockwise and anticlockwise for the pulse regulation knob come described
The size of pulse signal.
As a further improvement, the quantity of the needle point structure below the sealing shell is 6-9,6-9 needle point structure
In the uniform arranged parallel in the lower surface of sealing shell.
Preferably, the quantity of the needle point structure of the lower section of the sealing shell is 7, and the length of 7 needle point structures is different,
The length of needle point structure in periphery is longer than the needle point structure length in center, and whole is in concave.
Preferably, the material that the needle point structure uses is stainless steel physiotherapeutic needle.
The second object of the present invention is the production method for providing a kind of graphene joint pain patch, is included the following steps：
S1, weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, and the time of ultrasonic disperse, ultrasonic disperse is
30-60 minutes, ultrasonic temperature was controlled at 20-30 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
S3 integrally immerses 7 needle point structures in S1 after ultrasound using the entirety of the needle body in above-mentioned S2 as working electrode
Graphene oxide reaction solution in be used as working electrode, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
Three-electrode system described in S3 is carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is -5-5V,
The number of turns is scanned to enclose for 5-10；
Needle body is taken out from three-electrode system, after cleaning needle point structure with high purity water, cures 3- in vacuum drying chamber by S5
5 hours, solidification temperature was 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene and repair
The hair follicle physiotherapeutic needle needle point structure of decorations.
Preferably, ultrasonic temperature is 25 degrees Celsius in step S1, and ultrasonic time is 50 minutes.
Preferably, cyclic voltammetry scan current potential is 4V in step S4, and the scanning number of turns is 8 circles.
Beneficial effects of the present invention are as follows：
Graphite physiotherapeutic needle provided by the invention is led to by being internally provided with oscillation power and impulse generator in needle body
It crosses electrified wire to be connected with each other oscillation power and external power supply, after energization, impulse generator launches pulse signal, passes through needle
Pulse signal is transmitted to needle point mechanism by body, strengthens the needle point physiotherapy function of physiotherapeutic needle, pulse is provided with above needle body
Adjusting knob, pulse regulation knob are connected with each other with impulse generator, pass through turning clockwise and anticlockwise for pulse regulation knob
It moves to adjust the size for the pulse signal that impulse generator is sent out, pulse letter can be adjusted according to the practical requirement of sense of patient
Number size, bring better sensory effects, have graphene film layer, the resonable treatment of graphene film layer in the surface modification of needle point mechanism
During the physical therapy of needle stimulus hair follicle tissue, the far infrared absorbed suitable for body can be released, by hair follicle stimulating tissue,
Accelerate blood circulation, drive hair follicle activation, the atrophy of hair follicle can effectively be prevented even to be closed, meanwhile, graphene hair follicle reason
Drug is not used in the physical therapy process for treating needle, effectively avoids the chemical stimulation of drug ingedient, ensures health, suitable for permanent use.
Description of the drawings
Fig. 1 is graphene hair follicle physiotherapeutic needle structural schematic diagram；
Fig. 2 is graphene hair follicle physiotherapeutic needle front view；
Fig. 3 is that graphene hair follicle physiotherapeutic needle handle folds schematic diagram；
Fig. 4 is physiotherapeutic needle tip modification 10um scanning electron microscope schematic diagrames；
Fig. 5 is physiotherapeutic needle tip modification 5um scanning electron microscope schematic diagrames；
Fig. 6 is physiotherapeutic needle tip modification 2um scanning electron microscope schematic diagrames.
In figure：1- needle bodies；2- oscillation powers；3- impulse generators；4- sealing shells；5- rotation axis；6- needle handles；7- hands
Handle；8- electrified wires；9- rotation axis；10- pulse regulation knobs.
Specific implementation mode
It is described below for disclosing the present invention so that those skilled in the art can realize the present invention.It is excellent in being described below
Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.
Preparation method embodiment 1：
Preparation process：
S1, weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, and the time of ultrasonic disperse, ultrasonic disperse is
45 minutes, ultrasonic temperature was controlled at 25 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
S3 integrally immerses 7 needle point structures in S1 after ultrasound using the entirety of the needle body in above-mentioned S2 as working electrode
Graphene oxide reaction solution in be used as working electrode, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
S3 three-electrode systems are carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is 4V, scans the number of turns
For 8 circles；
Needle body is taken out from three-electrode system, after cleaning needle point structure with high purity water, cures 5 in vacuum drying chamber by S5
Hour, solidification temperature is 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene modified
Hair follicle physiotherapeutic needle needle point structure.
Preparation method embodiment 2：
Preparation process：
S1, weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, and the time of ultrasonic disperse, ultrasonic disperse is
45 minutes, ultrasonic temperature was controlled at 25 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
S3 integrally immerses 7 needle point structures in S1 after ultrasound using the entirety of the needle body in above-mentioned S2 as working electrode
Graphene oxide reaction solution in be used as working electrode, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
S3 three-electrode systems are carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is -5V, scanning circle
Number is 8 circles；
Needle body is taken out from three-electrode system, after cleaning needle point structure with high purity water, cures 5 in vacuum drying chamber by S5
Hour, solidification temperature is 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene modified
Hair follicle physiotherapeutic needle needle point structure.
Preparation method embodiment 3：
Preparation process：
S1, weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, and the time of ultrasonic disperse, ultrasonic disperse is
45 minutes, ultrasonic temperature was controlled at 25 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
S3 integrally immerses 7 needle point structures in S1 after ultrasound using the entirety of the needle body in above-mentioned S2 as working electrode
Graphene oxide reaction solution in be used as working electrode, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
S3 three-electrode systems are carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is -1V, scanning circle
Number is 8 circles；
Needle body is taken out from three-electrode system, after cleaning needle point structure with high purity water, cures 5 in vacuum drying chamber by S5
Hour, solidification temperature is 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene modified
Hair follicle physiotherapeutic needle needle point structure.
Preparation method embodiment 4：
Preparation process：
S1, weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, and the time of ultrasonic disperse, ultrasonic disperse is
45 minutes, ultrasonic temperature was controlled at 25 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
S3 integrally immerses 7 needle point structures in S1 after ultrasound using the entirety of the needle body in above-mentioned S2 as working electrode
Graphene oxide reaction solution in be used as working electrode, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
S3 three-electrode systems are carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is 5V, scans the number of turns
For 8 circles；
Needle body is taken out from three-electrode system, after cleaning needle point structure with high purity water, cures 5 in vacuum drying chamber by S5
Hour, solidification temperature is 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene modified
Hair follicle physiotherapeutic needle needle point structure.
Test example 1：
Statistical analysis is carried out using SPSS17.0 software packages.C57BL/6J mouse hair growing state scores and hair matter
Amount indicates that C57BL/6J mouse hair growing state scores and cells survival rate use one-way analysis of variance with X ± S,
C57BL/6J mouse hair quality uses rank sum test, level of significance α=0.05, C57BL/6J mouse to be randomly divided into control group
And experimental group, every group 10, daily respectively with common disinfection needle stimulus and graphene hair follicle physical therapy needle stimulus, each 30min.
The influence that graphene hair follicle physiotherapeutic needle grows mouse hair, physiotherapeutic needle continued stimulus 7d, control group hair removal section skin
Skin gray even black is removed in skin pinkiness, the depilation of physiotherapeutic needle group.Physiotherapeutic needle continued stimulus 14d, control group mice depilation
It is in black, experimental group and control group mice hair growth situation score to remove skin gray, physiotherapeutic needle group mouse hair removal section skin
Compared with the control group, the apparent (P of difference<0.01), it is shown in Table 1.Physical therapy needle stimulus 21d Hou Ge groups hair mass is weighed, as a result table
Bright, physical therapy needle stimulus group hair mass obviously overweights control group (P<0.05) 2, are shown in Table.
Table 1：C57BL/6J mouse hair growing state scores (X ± S, n=10)
Note：P compared with the control group<0.01.
Table 2：Influences (X ± S, n=10) of the physical therapy needle stimulus 21d to C57BL/6J mouse hair quality
Note：P compared with the control group<0.05.
The above result shows that graphene hair follicle physiotherapeutic needle can promote hair follicle hair growth, has and hair follicle hair cell is promoted to increase
The effect of value.
Test example 2
This test example is for investigating the comfortable effect after graphene hair follicle physiotherapeutic needle physical therapy.
Enter group crowd and use simple randomization method, by observation example by operation nursing time sequence, alternating is divided into physical therapy group (stone
Black alkene hair follicle physiotherapeutic needle) and control group (traditional care method group).Treatment group's completion 99, women 53, male 46, age
It is 37-86 Sui, 56.3 years old average, hair lengths 2-18cm.Control group 98, women 51, male 47, age 41-86 Sui put down
Equal 55.6 years old, send out 2-20cm long, two groups of genders, hair lengths, without significant difference (P>0.05), front and back baseline is comparable.
Traditional care method group：According to《Basic nursing science》(People's Health Publisher's version in 2006) hair nursing piece is held
Row.
Data are handled using SPSS15.0 softwares, and measurement data is met normality and homogeneity of variance and examined using t, is met just
State property and do not meet homogeneity of variance and (i.e. t' inspections) examined using correction t, do not meet normality then using rank sum test；Count money
Material uses chi-square criterion.
Two groups of comfort levels compare, and comfort level diversity of values is not statistically significant (P between two groups>0.05) 3, are shown in Table.
Table 3：Comfort level scoring is compared (X ± S) between two groups
Conventional method group and physical therapy needle stimulus group care operation time compare, and physical therapy needle stimulus group is substantially better than conventional method
Group, difference all have statistical significance (P<0.05) 4, are shown in Table.
Table 4：Two groups of operating times compare (n, %)
Result of study is shown, is considerably less than conventional method group using graphene hair follicle physiotherapeutic needle operation required time, is removed this
Except, traditional physical therapy process physical therapy time is long, and graphene hair follicle physical therapy group greatly shortens the operating time, alleviates physical therapy
Labor intensity, reduce cost and the time of physical therapy, improve physical therapy work efficiency.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection domain by appended claims and its
Equivalent defines.
Claims (12)
1. a kind of graphene hair follicle physiotherapeutic needle, including needle body (1), the needle body (1) be internally provided with oscillation power (2) and
The outside of impulse generator (3), the needle body (1) is sealing shell (4), the oscillation power (2) and the impulse generator
(3) fixed in position is needle point structure (5) in the bottom end of the sealing shell (4) in the inside of the sealing shell (4), special
Sign is：The top of the needle point structure (5) is needle handle (6), and the needle point structure (5) passes through the needle handle (6) above it
It is inserted into the inside of the sealing shell (4), the lower half portion of the needle point structure (5) is set to the outer of the sealing shell (4)
Portion, needle point structure (5) the surface deposition launch 8- after having one layer of fine and close graphene film layer, the graphene film layer to be powered
15 microns of far infrared waves, so as to human body cell under hair follicle stimulating.
2. graphene hair follicle physiotherapeutic needle according to claim 1, it is characterised in that：Pacify in the left side of the sealing shell (4)
Equipped with handle (7), it is hollow structure in the inside of the handle (7), has energization to lead in the hollow handle (7) positioned inside
Line (8), so that the oscillation power (2) is connected with external power supply.
3. graphene hair follicle physiotherapeutic needle according to claim 2, it is characterised in that：Outside the handle (7) and the sealing
Rotation axis (9) is installed between shell (4), by the rotation axis (9) realize the handle (7) and the sealing shell (4) it
Between rotation, when on the shelf, between the handle (7) and the sealing shell (4) be in parallel receiving state, in use,
Positioned vertical between the handle (7) and the sealing shell (4).
4. graphene breast hair follicle physiotherapeutic needle according to claim 1, it is characterised in that：The top of the needle body (1) is arteries and veins
Adjusting knob (10) is rushed, the pulse regulation knob (10) is connected with each other with the impulse generator (3), passes through the pulse tune
The rotation clockwise and anticlockwise of knob (10) is saved to adjust the size for the pulse signal that the impulse generator (3) is sent out.
5. according to any graphene hair follicle physiotherapeutic needles of claim 1-4, it is characterised in that：Under the sealing shell (4)
The quantity of the needle point structure (5) of side is 6-9, and 6-9 needle point structure (5) is uniform in the lower surface of the sealing shell (4)
Arranged parallel.
6. graphene hair follicle physiotherapeutic needle according to claim 5, it is characterised in that：The lower section of the sealing shell (4)
The quantity of needle point structure (5) is 7, and the length of 7 needle point structures (5) is identical, and the bottom end of 7 needle point structures (5) is in same
Plane.
7. graphene hair follicle physiotherapeutic needle according to claim 5, it is characterised in that：The lower section of the sealing shell (4)
The quantity of needle point structure (5) is 7, and the length of 7 needle point structures (5) is different, and the length of the needle point structure (5) in periphery is long
In needle point structure (5) length in center, whole is in concave.
8. graphene hair follicle physiotherapeutic needle according to claim 1, it is characterised in that：The material that the needle point structure (5) uses
Material is stainless steel physiotherapeutic needle.
9. graphene hair follicle physiotherapeutic needle according to claim 1, it is characterised in that：The material that the needle point structure (5) uses
Material is silver physiotherapeutic needle.
10. a kind of method of modifying of graphene hair follicle physiotherapeutic needle needle point structure, it is characterised in that：Include the following steps：
S1 weighs 3-5mg graphene oxides, is added in 20 ml deionized waters, ultrasonic disperse, and the time of ultrasonic disperse is 30-
60 minutes, ultrasonic temperature was controlled at 20-30 degrees Celsius；
S2, it is smooth that needle point structure is polishing to surface, will 7 needle point structures be fixedly mounted in needle body；
7 needle point structures are integrally immersed the oxygen in S1 after ultrasound by S3 using the entirety of the needle body in above-mentioned S2 as working electrode
Working electrode is used as in graphite alkene reaction liquid, using platinum electrode as auxiliary electrode, saturated calomel electrode is reference electrode；
Three-electrode system described in S3 is carried out cyclic voltammetry scan by S4 using cyclic voltammetry, and scanning current potential is -5-5V, scanning
The number of turns is enclosed for 5-10；
S5 takes out needle body from three-electrode system, and after cleaning needle point structure with high purity water, it is small to cure 3-5 in vacuum drying chamber
When, solidification temperature is 60 degrees Celsius, and it is smooth to carry out being polishing to surface after taking-up, cleans, dries up again, obtains graphene modified
Hair follicle physiotherapeutic needle needle point structure.
11. the method for modifying of graphene hair follicle physiotherapeutic needle needle point structure according to claim 10, it is characterised in that：Step
Ultrasonic temperature is 25 degrees Celsius in S1, and ultrasonic time is 50 minutes.
12. the method for modifying of graphene hair follicle physiotherapeutic needle needle point structure according to claim 10, it is characterised in that：Step
Cyclic voltammetry scan current potential is 4V in S4, and the scanning number of turns is 8 circles.
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