CN108455566A - The silicon dioxide nano composite material and its preparation method and application of fullerene insertion - Google Patents
The silicon dioxide nano composite material and its preparation method and application of fullerene insertion Download PDFInfo
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- CN108455566A CN108455566A CN201810216455.5A CN201810216455A CN108455566A CN 108455566 A CN108455566 A CN 108455566A CN 201810216455 A CN201810216455 A CN 201810216455A CN 108455566 A CN108455566 A CN 108455566A
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- fullerene
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 73
- 229910003472 fullerene Inorganic materials 0.000 title claims abstract description 52
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 36
- 239000002114 nanocomposite Substances 0.000 title claims abstract description 32
- 238000003780 insertion Methods 0.000 title claims abstract description 30
- 239000000463 material Substances 0.000 title claims abstract description 25
- 230000037431 insertion Effects 0.000 title claims abstract description 23
- 235000012239 silicon dioxide Nutrition 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 8
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims abstract description 6
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000013504 Triton X-100 Substances 0.000 claims abstract description 4
- 229920004890 Triton X-100 Polymers 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 238000003384 imaging method Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000019441 ethanol Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000004064 cosurfactant Substances 0.000 claims description 5
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 239000000908 ammonium hydroxide Substances 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 230000035484 reaction time Effects 0.000 claims 1
- 239000002086 nanomaterial Substances 0.000 abstract description 9
- 239000002105 nanoparticle Substances 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 238000012956 testing procedure Methods 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000013335 mesoporous material Substances 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- -1 n-hexyl alcohols Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- VDGJOQCBCPGFFD-UHFFFAOYSA-N oxygen(2-) silicon(4+) titanium(4+) Chemical compound [Si+4].[O-2].[O-2].[Ti+4] VDGJOQCBCPGFFD-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N2015/0294—Particle shape
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
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Abstract
The invention belongs to nano material preparation technologies and special material technical field, and in particular to a kind of mesoporous silicon dioxide nano composite material and preparation method of fullerene insertion and application.The Reverse Microemulsion System being made of hexamethylene, Triton X-100 (TritonX 100), n-hexyl alcohol and aqueous solution is specifically first built, later by C70Fullerene is encapsulated in the silica nano material being embedded in get fullerene in the core of Nano particles of silicon dioxide.Preparation method is simple, raw material sources are abundant, applied widely.And the nano particle diameter of preparation is small, specific surface area is high, load capacity is high, good biocompatibility.
Description
Technical field
The invention belongs to nano material preparation technologies and special material technical field, and in particular to a kind of C70Fullerene is embedded in
The preparation method and application of the nanocomposite of silica.
Background technology
Fullerene be it is a kind of it is novel contain carbon nanomaterial, because its unique structure and physicochemical properties biology, medicine,
Superconduction, optics and catalysis etc. are multi-field extremely wide application prospect.Meanwhile fullerene and its derivative are with anti-oxidant
Activity, cytoprotection, antibacterial activity, antivirus action, carrier band drug and oncotherapy isoreactivity, therefore, in biology and
Medical domain is widely used.But fullerene itself is difficult to be directly dissolved in biological friendly medium, and it is remaining in preparation process
Organic solvent easily causes bio-toxicity, it usually needs it is living further to improve its biology that suitable chemical modification is carried out to it
Property.
Improving the water-soluble method of fullerene mainly has following 3 kinds：(1) ultrasound prepares fullerene water colloidal sol；(2) it prepares rich
Strangle the water-soluble inclusion complex of alkene；(3) in Fullerene Carbon cage surface-bonded water soluble group, fullerene synthesis derivative.Currently, compared with
Good solution is to add multiple highly polar groups, such as-OH ,-COOH and-NH on Fullerene Carbon cage surface2Deng synthesis
Assign fullerene new physicochemical properties while water-soluble preferable fullerene derivate.But the chemistry in fullerene is repaiied
Decorations reaction in easily formed add derivative, it is difficult to accomplish selectivity synthesis, this be after isolate and purify cause it is larger
It is difficult.Therefore, it is necessary to seek a kind of simple effective method to improve the water solubility of fullerene.
Silica is widely distributed, has good biocompatibility.Metaporous silicon dioxide material is a kind of with high ratio
The controllable novel inorganic biomaterial of surface area, big pore capacities, morphology and size, mesopore silicon dioxide nano material have had both Jie
The double grading of Porous materials and nano material has very high chemical stability, biocompatibility, synthesis convenient and at low cost
The features such as honest and clean, in addition to other than traditional mesoporous material application field, in other field such as biological medicine and genetic engineering etc.
Also show great application prospect.
The present invention is by reverse microemulsion process by fullerene (C70) center of meso-porous titanium dioxide silicon matrix is embedded in form water
The good nanocomposite of dissolubility.The nanocomposite has meso-hole structure, large specific surface area, biocompatibility
Good and stability is high.
Invention content
It is an object of the invention to solve deficiency in the prior art, the mesoporous silicon oxide of fullerene insertion is provided
Nanocomposite.The nanocomposite is by reverse microemulsion process by fullerene (C70) it is encapsulated in silica nanometer
Formation is prepared in the core of particle.Obtained nanocomposite has good biocompatibility, is a good carrier
Platform has a good application prospect in fields such as drug delivery, cell imaging, living imagings, and can be used in cancer and swell
Tumor therapy field.
The specific technical solution of the present invention is as described below：
A kind of C70The preparation method of the mesoporous silicon dioxide nano composite material of fullerene insertion, specifically includes following step
Suddenly：
(1) surfactant, cosurfactant, hexamethylene, deionized water are mixed with certain volume ratio,
Form reverse micro emulsion；
(2) by C70Fullerene is dissolved in toluene solution and is added in above-mentioned reverse micro emulsion, adds hydroxide later
Ammonium and tetraethoxysilane, react 40-50h at room temperature；
(3) ethyl alcohol is added to stop reacting, products therefrom ethyl alcohol centrifuge washing is three times to obtain the two of fullerene insertion
Aoxidize silicon nano material.
Further, the surfactant in the step of above-mentioned preparation method (1) is Triton X-100
(Triton X-100), cosurfactant are n-hexyl alcohol, and surfactant, cosurfactant, hexamethylene, deionized water
Volume ratio be 5： 2.5：50：1；
Further, the C in the step of above-mentioned preparation method (2)70Fullerene structure formula is as follows：
Further, the grain size of the mesoporous silicon dioxide nano composite material of the fullerene insertion is about 50-70nm.
Further, the mesoporous silicon dioxide nano composite material of fullerene insertion of the present invention can be applied to drug
In the treatment of transmission, cell imaging, living imaging, cancer and tumour.
The invention has the advantages that：
1, the silicon dioxide nano composite material grain size of fullerene insertion of the present invention is small, specific surface is high, load capacity
Greatly, good biocompatibility；
2, the preparation method of the nanocomposite is simple, abundant raw material, it is applied widely, can be used for industrial metaplasia
Production；
3, the nanocomposite is a good carrier platform, can be applied not only to drug delivery, cell imaging,
The fields such as living imaging also highlight preferable effect in the treatment of cancer and tumour.
Description of the drawings
Fig. 1 is the scanning electron of the silicon dioxide nano composite material of the fullerene insertion prepared in the embodiment of the present invention 2
Microscope figure；
Fig. 2 is the transmitted electron of the silicon dioxide nano composite material of the fullerene insertion prepared in the embodiment of the present invention 2
Microscope figure；
Fig. 3 is that the dynamic optical of the silicon dioxide nano composite material of the fullerene insertion prepared in the embodiment of the present invention 2 dissipates
Penetrate figure.
Specific implementation mode
The content that following embodiment further illustrates the present invention, but should not be construed as limiting the invention.Without departing substantially from
In the case of essence of the present invention, to changing and replacing made by the method for the present invention, step or condition, the model of the present invention is belonged to
It encloses.
Embodiment 1
(1) by 1ml Triton X-100,0.5ml n-hexyl alcohols, 10ml hexamethylenes and 0.2ml deionized waters mix
To form reverse micro emulsion；
(2) and then by 4mg C70Fullerene is dissolved in toluene solution and is added in above-mentioned solution, is slowly added later
Ammonium hydroxide and tetraethoxysilane, react 48h at room temperature；
(3) the last 2ml ethyl alcohol that is added in the sample is to stop reacting, and products therefrom is with ethyl alcohol centrifuge washing three times to obtain
The silica nano material of fullerene insertion.
Embodiment 2：The property of the silica nano material of fullerene insertion provided in this embodiment in order to better understand
Can, it is characterized by following test：
Nanotopography and grain size test
Silica (the i.e. C of fullerene insertion70S) pattern of nanocomposite and particle diameter distribution test
Fig. 1 is silica (the i.e. C of fullerene provided by the invention insertion70S) scanning electron of nanocomposite is aobvious
Micro mirror figure.
Specifically testing procedure is：The sample solution of 20 a concentration of 0.2mg/ml of μ l is taken to drop on silicon chip, after sample drying
Carry out pattern test.Silica (the i.e. C of fullerene insertion70S) grain size of nano-particle is 50-70nm, from Fig. 1 scanning electrons
Microscope graphical results can be seen that the uniform particle diameter of nano-particle provided by the invention, favorable dispersibility；
Fig. 2 is silica (the i.e. C of fullerene provided by the invention insertion70S) transmitted electron of nanocomposite is aobvious
Micro mirror figure.
Specifically testing procedure is：The sample solution of 20 a concentration of 0.2mg/ml of μ l is taken to drop on copper mesh, after sample drying
Carry out pattern test.Silica (the i.e. C of fullerene insertion70S) grain size of nano-particle is 50-70nm, aobvious from transmitted electron
Micro mirror graphical results can be seen that the material is a nucleocapsid, and core is fullerene, and outside is Metaporous silicon dioxide material,
And the uniform particle diameter of nano-particle provided by the invention, show that result is consistent with scanning electron microscope diagram；
Fig. 3 is silica (the i.e. C of fullerene provided by the invention insertion70S) the dynamic light scattering of nanocomposite
Figure.
Specifically testing procedure is：It takes the sample solution of 20 a concentration of 0.2mg/ml of μ l in plastic cuvette, measures fowler
Silica (the i.e. C of alkene insertion70S) the particle diameter distribution of nano-particle, the result shown from figure three can be seen that the present invention and carried
The nano particle diameter narrow distribution range of confession, the display result one with scanning electron microscope diagram and transmission electron microscope figure
It causes.
Claims (9)
1. a kind of preparation method of the silicon dioxide nano composite material of fullerene insertion, which is characterized in that specifically include following
Step：
(1) surfactant, cosurfactant, hexamethylene, deionized water are mixed with certain volume ratio, is formed
Reverse micro emulsion；
(2) by C70Fullerene is dissolved in toluene solution and is added in the reverse micro emulsion, later add ammonium hydroxide and
Tetraethoxysilane is reacted.
(3) ethyl alcohol is added and stops reaction, products therefrom obtains nanocomposite three times with ethyl alcohol centrifuge washing.
2. the preparation method of the silicon dioxide nano composite material of fullerene insertion as described in claim 1, which is characterized in that
Surfactant described in step 1 is Triton X-100, and cosurfactant is n-hexyl alcohol, and surfactant, helps table
Face activating agent, hexamethylene, deionized water volume ratio be 5：2.5：50：1.
3. the preparation method of the silicon dioxide nano composite material of fullerene insertion as described in claim 1, which is characterized in that
C described in step 270Fullerene structure formula is as follows.
4. the preparation method of the silicon dioxide nano composite material of fullerene insertion as described in claim 1, which is characterized in that
The reaction time being added in step 2 after ammonium hydroxide and tetraethoxysilane is 40-50h.
5. a kind of silicon dioxide nano composite material of fullerene insertion, which is characterized in that be by any one of claim 1-4
Prepared by the method.
6. the silicon dioxide nano composite material of fullerene insertion as claimed in claim 5, which is characterized in that the nanometer is multiple
The grain size of condensation material is 50-70nm.
7. the silicon dioxide nano composite material of the fullerene insertion as described in any one of claim 1-5 is in drug delivery
Application.
8. the silicon dioxide nano composite material of the fullerene insertion as described in any one of claim 1-5 in cell imaging and
Application in living imaging.
9. the silicon dioxide nano composite material of the fullerene insertion as described in any one of claim 1-5 in treating cancer and
Application in tumour.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109608699A (en) * | 2018-12-26 | 2019-04-12 | 哈尔滨工大泰铭科技有限公司 | A kind of micro-nano compound particle and its preparation process and device |
| CN114948762A (en) * | 2021-12-31 | 2022-08-30 | 北京福纳康生物技术有限公司 | Fullerene powder material and preparation method and application thereof |
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