CN108451918A - A kind of chlorpromazine tablet and preparation method thereof - Google Patents
A kind of chlorpromazine tablet and preparation method thereof Download PDFInfo
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- CN108451918A CN108451918A CN201810589879.6A CN201810589879A CN108451918A CN 108451918 A CN108451918 A CN 108451918A CN 201810589879 A CN201810589879 A CN 201810589879A CN 108451918 A CN108451918 A CN 108451918A
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- chlorpromazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Abstract
The present invention provides a kind of chlorpromazine tablet, it is related to pharmaceutical technology field, including lactose, cornstarch, PVP K30, purified water, chlorpromazine hydrochloride, carboxyrnethyl starch sodium (A classes), anhydrous silica gel, 14 parts of magnesium stearate, monkey mushroom extract, Opadry 21S58740, methanol, dichloromethane, antioxidant, by lactose (314 type), cornstarch, monkey mushroom extract is using mixed mechanism at filler, by chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), mixing machine is added after carrying out sieving processing using shaking screen or stainless steel sieve in magnesium stearate, purified water is added, softwood is made, add PVP K30, antioxidant, use tabletting granulator tabletting, Opadry 21S58740, methanol, dichloromethane is added to seed-coating machine and is coated to tablet, obtain chlorpromazine tablet.Chlorpromazine tablet material availability of the present invention is high, and disintegration leaches velocity-stabilization, and dissolution rate is high, stable quality, and drug release rate is stablized, easy to carry and use and simple for process, reduces injury and burden of the tablet to stomach.
Description
Technical field
The present invention relates to pharmaceutical technology field, specially a kind of chlorpromazine tablet and preparation method thereof.
Background technology
Chlorpromazine HCL tablet, indication are the positives such as restless 1. pairs of excitements, illusion vain hope, the disturbance of thought and conduct disorder
Symptom has a better effect.For schizophrenia, mania or other psychotic disorders.2. preventing or arresting vomiting, caused by a variety of causes
Vomiting or intractable hiccup.
Chlorpromazine tablet preparation disintegration currently on the market is slow, and uses routine prescription and conventional fabrication process and auxiliary
Material, it is difficult to solve the lower technical barrier of bioavilability in drug dissolution and human body, can hinder after a number of uses
Stomach brings great burden to human body.
Invention content
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of chlorpromazine tablet and preparation method thereof, it is more to solve maincenter
The antagonism of bar amine receptor, spat suitable for treatment mental disease, town, heart failure the problem of.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs：A kind of chlorpromazine tablet, by following heavy
The raw material of the proportioning of amount is made：It is 130-140 parts of lactose (314 type), 13-17 parts of cornstarch, 5-7 parts of povidone (K30), pure
Change 18-22 parts of water, 28-33 parts of chlorpromazine hydrochloride, 8-12 parts of carboxyrnethyl starch sodium (A classes), 1-3 parts of anhydrous silica gel, magnesium stearate 1-
4 parts, it is 1-3 parts of monkey mushroom extract, 5-7 parts of Opadry (21S58740), 44-46 parts of methanol, 65-68 parts of dichloromethane, anti-oxidant
0.3-0.5 parts of agent.
Preferably, the antioxidant is stannous chloride.
Preferably, the additive is one kind in talcum powder, cornstarch, pharmaceutical grade crosslinked polyvinylpyrrolidone
Or it is a variety of.
Preferably, the water content of the starch slurry is 10%-20%.
A kind of preparation method of chlorpromazine tablet according to claim 1, it is characterised in that：Include the following steps：
(1), lactose (314 type), cornstarch, monkey mushroom extract are used into HZD-2000 automatic lifting hopper mixing machines
Filler is made；
(2), chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), magnesium stearate are used into shaking screen or stainless steel
HZD-2000 automatic lifting hopper mixing machines are added after carrying out sieving processing in sieve, and lactose granule is added and is mixed, hybrid process
Filler is added afterwards to be uniformly mixed, purified water is added, softwood is made；
(3), povidone (K30), antioxidant is taken to be added in softwood, mechanical agitation is uniformly mixed, obtains label object
Material；
(4), label material is poured into PG26 Highspeedrotarytabletpress, pelletized, it is dry, label is made；
(5), it takes Opadry (21S58740), methanol, dichloromethane to be added in GB-150C high-efficiency coating machines and mix, sprays
It is coated on label, obtains chlorpromazine tablet；
(6), semi-finished product are tested in intermediate station；
(7), it packs, and carries out product inspection.
Preferably, the seed-coating machine rotating speed is set as 2-6 revs/min, and inlet air temperature is set as 45 DEG C (40-60 DEG C), heat
Wind fan delivery is set as 1700-2300m3/h, and the pressure difference between room and seed-coating machine is made to be maintained at -10Pa or more.
Preferably, the thickness that the Opadry (21S58740), methanol, dichloromethane spray is 0.03-0.05mm.
Preferably, the HZD-2000 automatic liftings hopper mixing machine rotating speed is set as 9 turns, mixes 10 minutes.
Preferably, the PG26 Highspeedrotarytabletpress on circle, biconvex, a diameter of 9.5mm that carves characters using rushing
Mould and circle, a diameter of 9.5mm lower punches of biconvex.
(3) advantageous effect
The present invention provides a kind of chlorpromazine tablets and preparation method thereof.Has following advantageous effect：
The chlorpromazine tablet and preparation method thereof, this chlorpromazine tablet are the antagonistic of central dopaminergic receptor, are suitable for treatment
Mental disease, town spit, heart failure, is added to anhydrous silica gel, carboxyrnethyl starch sodium increases the dissolution rate of chlorpromazine, in two hydroxypropyls
Monkey mushroom extract is added in the auxiliary material of theophylline piece can carry out conserving stomach when taking medicine, and reduce tablet pair
The injury of stomach and burden.Chlorpromazine tablet material availability is high, and disintegration leaches velocity-stabilization, and dissolution rate is high, stable quality, drug release
Velocity-stabilization, easy to carry and use and simple for process, few using supplementary product kind, production process is short, at low cost.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention is clearly and completely retouched
It states, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the present invention
In embodiment, every other implementation obtained by those of ordinary skill in the art without making creative efforts
Example, shall fall within the protection scope of the present invention.
Case study on implementation one：
A kind of chlorpromazine tablet is made of the raw material of the proportioning of following weight：130 parts of lactose (314 type), cornstarch 13
Part, 5 parts of povidone (K30), 18 parts of purified water, 28 parts of chlorpromazine hydrochloride, 8 parts of carboxyrnethyl starch sodium (A classes), 1 part of anhydrous silica gel,
1 part of magnesium stearate, 1 part of monkey mushroom extract, 5 parts of Opadry (21S58740), 44 parts of methanol, 65 parts of dichloromethane, antioxidant
0.3 part.
Antioxidant is stannous chloride.
Additive is one or more in talcum powder, cornstarch, pharmaceutical grade crosslinked polyvinylpyrrolidone.
The water content of starch slurry is 10%-20%.
A kind of preparation method of chlorpromazine tablet according to claim 1, it is characterised in that：Include the following steps：
(1), lactose (314 type), cornstarch, monkey mushroom extract are used into HZD-2000 automatic lifting hopper mixing machines
Filler is made；
(2), chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), magnesium stearate are used into shaking screen or stainless steel
HZD-2000 automatic lifting hopper mixing machines are added after carrying out sieving processing in sieve, and lactose granule is added and is mixed, hybrid process
Filler is added afterwards to be uniformly mixed, purified water is added, softwood is made；
(3), povidone (K30), antioxidant is taken to be added in softwood, mechanical agitation is uniformly mixed, obtains label object
Material；
(4), label material is poured into PG26 Highspeedrotarytabletpress, pelletized, it is dry, label is made；
(5), it takes Opadry (21S58740), methanol, dichloromethane to be added in GB-150C high-efficiency coating machines and mix, sprays
It is coated on label, obtains chlorpromazine tablet；
(6), semi-finished product are tested in intermediate station；
(7), it packs, and carries out product inspection.
Seed-coating machine rotating speed is set as 2-6 revs/min, and inlet air temperature is set as 45 DEG C (40-60 DEG C), air-heater air quantity
It is set as 1700-2300m3/h, the pressure difference between room and seed-coating machine is made to be maintained at -10Pa or more.
The thickness that Opadry (21S58740), methanol, dichloromethane spray is 0.03-0.05mm.
HZD-2000 automatic lifting hopper mixing machine rotating speeds are set as 9 turns, mix 10 minutes.
The use of PG26 Highspeedrotarytabletpress circle, biconvex, carve characters a diameter of 9.5mm upper trimming dies and circle, two
The convex a diameter of 9.5mm lower punches in face.
Case study on implementation two：
A kind of chlorpromazine tablet is made of the raw material of the proportioning of following weight：135 parts of lactose (314 type), cornstarch 15
Part, 6 parts of povidone (K30), 20 parts of purified water, 30 parts of chlorpromazine hydrochloride, 10 parts of carboxyrnethyl starch sodium (A classes), 2 parts of anhydrous silica gel,
2 parts of magnesium stearate, 2 parts of monkey mushroom extract, 6 parts of Opadry (21S58740), 45 parts of methanol, 66 parts of dichloromethane, antioxidant
0.4 part.
Antioxidant is stannous chloride.
Additive is one or more in talcum powder, cornstarch, pharmaceutical grade crosslinked polyvinylpyrrolidone.
The water content of starch slurry is 10%-20%.
A kind of preparation method of chlorpromazine tablet according to claim 1, it is characterised in that：Include the following steps：
(1), lactose (314 type), cornstarch, monkey mushroom extract are used into HZD-2000 automatic lifting hopper mixing machines
Filler is made；
(2), chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), magnesium stearate are used into shaking screen or stainless steel
HZD-2000 automatic lifting hopper mixing machines are added after carrying out sieving processing in sieve, and lactose granule is added and is mixed, hybrid process
Filler is added afterwards to be uniformly mixed, purified water is added, softwood is made；
(3), povidone (K30), antioxidant is taken to be added in softwood, mechanical agitation is uniformly mixed, obtains label object
Material；
(4), label material is poured into PG26 Highspeedrotarytabletpress, pelletized, it is dry, label is made；
(5), it takes Opadry (21S58740), methanol, dichloromethane to be added in GB-150C high-efficiency coating machines and mix, sprays
It is coated on label, obtains chlorpromazine tablet；
(6), semi-finished product are tested in intermediate station；
(7), it packs, and carries out product inspection.
Seed-coating machine rotating speed is set as 2-6 revs/min, and inlet air temperature is set as 45 DEG C (40-60 DEG C), air-heater air quantity
It is set as 1700-2300m3/h, the pressure difference between room and seed-coating machine is made to be maintained at -10Pa or more.
The thickness that Opadry (21S58740), methanol, dichloromethane spray is 0.03-0.05mm.
HZD-2000 automatic lifting hopper mixing machine rotating speeds are set as 9 turns, mix 10 minutes.
The use of PG26 Highspeedrotarytabletpress circle, biconvex, carve characters a diameter of 9.5mm upper trimming dies and circle, two
The convex a diameter of 9.5mm lower punches in face.
Case study on implementation three：
A kind of chlorpromazine tablet is made of the raw material of the proportioning of following weight：140 parts of lactose (314 type), cornstarch 7
Part, 7 parts of povidone (K30), 22 parts of purified water, 33 parts of chlorpromazine hydrochloride, 12 parts of carboxyrnethyl starch sodium (A classes), 3 parts of anhydrous silica gel,
4 parts of magnesium stearate, 3 parts of monkey mushroom extract, 7 parts of Opadry (21S58740), 46 parts of methanol, 68 parts of dichloromethane, antioxidant
0.5 part.
Antioxidant is stannous chloride.
Additive is one or more in talcum powder, cornstarch, pharmaceutical grade crosslinked polyvinylpyrrolidone.
The water content of starch slurry is 10%-20%.
A kind of preparation method of chlorpromazine tablet according to claim 1, it is characterised in that：Include the following steps：
(1), lactose (314 type), cornstarch, monkey mushroom extract are used into HZD-2000 automatic lifting hopper mixing machines
Filler is made；
(2), chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), magnesium stearate are used into shaking screen or stainless steel
HZD-2000 automatic lifting hopper mixing machines are added after carrying out sieving processing in sieve, and lactose granule is added and is mixed, hybrid process
Filler is added afterwards to be uniformly mixed, purified water is added, softwood is made；
(3), povidone (K30), antioxidant is taken to be added in softwood, mechanical agitation is uniformly mixed, obtains label object
Material；
(4), label material is poured into PG26 Highspeedrotarytabletpress, pelletized, it is dry, label is made；
(5), it takes Opadry (21S58740), methanol, dichloromethane to be added in GB-150C high-efficiency coating machines and mix, sprays
It is coated on label, obtains chlorpromazine tablet；
(6), semi-finished product are tested in intermediate station；
(7), it packs, and carries out product inspection.
Seed-coating machine rotating speed is set as 2-6 revs/min, and inlet air temperature is set as 45 DEG C (40-60 DEG C), air-heater air quantity
It is set as 1700-2300m3/h, the pressure difference between room and seed-coating machine is made to be maintained at -10Pa or more.
The thickness that Opadry (21S58740), methanol, dichloromethane spray is 0.03-0.05mm.
HZD-2000 automatic lifting hopper mixing machine rotating speeds are set as 9 turns, mix 10 minutes.
The use of PG26 Highspeedrotarytabletpress circle, biconvex, carve characters a diameter of 9.5mm upper trimming dies and circle, two
The convex a diameter of 9.5mm lower punches in face.
The embodiment of the present invention and the chlorpromazine tablet table of comparisons：
From above table as can be seen that compared with common chlorpromazine tablet in the market, the present invention, which can have, effectively to be carried
The dissolution rate and trap of high drug, while absorption of the human body to drug is improved, help patient to get well.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, without necessarily requiring or implying between these entities or operation
There are any actual relationship or orders.Moreover, the terms "include", "comprise" or its any other variant are intended to
Cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements includes not only that
A little elements, but also include other elements that are not explicitly listed, or further include for this process, method, article or
The intrinsic element of equipment.In the absence of more restrictions.By sentence " including one ... the element limited, and
It is not excluded in process, method, article or equipment in the process, method, article or apparatus that includes the element that there is also other identical elements ".
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of chlorpromazine tablet, it is characterised in that：It is made of the raw material of the proportioning of following weight：Lactose (314 type) 130-140
Part, 13-17 parts of cornstarch, 5-7 parts of povidone (K30), 18-22 parts of purified water, 28-33 parts of chlorpromazine hydrochloride, carboxymethylstarch
8-12 parts of sodium (A classes), 1-3 parts of anhydrous silica gel, 1-4 parts of magnesium stearate, 1-3 parts of monkey mushroom extract, Opadry (21S58740) 5-7
Part, 44-46 parts of methanol, 65-68 parts of dichloromethane, 0.3-0.5 parts of antioxidant.
2. a kind of chlorpromazine tablet according to claim 1, it is characterised in that：The antioxidant is stannous chloride.
3. a kind of chlorpromazine tablet according to claim 1, it is characterised in that：The additive be talcum powder, cornstarch,
It is one or more in pharmaceutical grade crosslinked polyvinylpyrrolidone.
4. a kind of chlorpromazine tablet according to claim 1, it is characterised in that：The water content of the starch slurry is 10%-
20%.
5. a kind of preparation method of chlorpromazine tablet according to claim 1, it is characterised in that：Include the following steps：
(1), by lactose (314 type), cornstarch, monkey mushroom extract using HZD-2000 automatic lifting hopper mixed mechanisms at filling out
Fill agent；
(2), by chlorpromazine hydrochloride, anhydrous silica gel, carboxyrnethyl starch sodium (A classes), magnesium stearate using shaking screen or stainless steel sieve into
HZD-2000 automatic lifting hopper mixing machines are added after row sieving processing, lactose granule is added and is mixed, adds after hybrid process
Enter filler to be uniformly mixed, purified water is added, softwood is made；
(3), povidone (K30), antioxidant is taken to be added in softwood, mechanical agitation is uniformly mixed, obtains label material；
(4), label material is poured into PG26 Highspeedrotarytabletpress, pelletized, it is dry, label is made；
(5), it takes Opadry (21S58740), methanol, dichloromethane to be added in GB-150C high-efficiency coating machines and mix, is sprayed on
On label, chlorpromazine tablet is obtained；
(6), semi-finished product are tested in intermediate station；
(7), it packs, and carries out product inspection.
6. preparation method according to claim 5, it is characterised in that：The seed-coating machine rotating speed is set as 2-6 revs/min,
Inlet air temperature is set as 45 DEG C (40-60 DEG C), and air-heater air quantity is set as 1700-2300m3/h, make room and seed-coating machine it
Between pressure difference be maintained at -10Pa or more.
7. preparation method according to claim 5, it is characterised in that：The Opadry (21S58740), methanol, dichloro
The thickness of methane spraying is 0.03-0.05mm.
8. preparation method according to claim 5, it is characterised in that：The HZD-2000 automatic liftings hopper mixing machine turns
Speed is set as 9 turns, mixes 10 minutes.
9. preparation method according to claim 5, it is characterised in that：The PG26 Highspeedrotarytabletpress is using circle
Shape, biconvex, carve characters a diameter of 9.5mm upper trimming dies and circle, a diameter of 9.5mm lower punches of biconvex.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810589879.6A CN108451918A (en) | 2018-06-08 | 2018-06-08 | A kind of chlorpromazine tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810589879.6A CN108451918A (en) | 2018-06-08 | 2018-06-08 | A kind of chlorpromazine tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108451918A true CN108451918A (en) | 2018-08-28 |
Family
ID=63216134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810589879.6A Pending CN108451918A (en) | 2018-06-08 | 2018-06-08 | A kind of chlorpromazine tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108451918A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292520A (en) * | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| CN101190199A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Chlorpromazine hydrochloride chewable tablets for dog or cat |
-
2018
- 2018-06-08 CN CN201810589879.6A patent/CN108451918A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292520A (en) * | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| CN101190199A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Chlorpromazine hydrochloride chewable tablets for dog or cat |
Non-Patent Citations (3)
| Title |
|---|
| 张启玉等: "盐酸氯丙嗪片的制备及溶出度测定", 《上海医药》 * |
| 张立主编: "《猴头菇与胃健康》", 30 November 2014, 中国医药科技出版社 * |
| 高涛等主编: "《药剂学》", 31 May 2017, 湖北科学技术出版社 * |
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Application publication date: 20180828 |