CN108447370A - It imitates the prosthese of lesion breast and its designs with preparation method, to the method for human breast lesion detection device optimization or check and correction - Google Patents
It imitates the prosthese of lesion breast and its designs with preparation method, to the method for human breast lesion detection device optimization or check and correction Download PDFInfo
- Publication number
- CN108447370A CN108447370A CN201810394619.3A CN201810394619A CN108447370A CN 108447370 A CN108447370 A CN 108447370A CN 201810394619 A CN201810394619 A CN 201810394619A CN 108447370 A CN108447370 A CN 108447370A
- Authority
- CN
- China
- Prior art keywords
- prosthese
- lesion
- breast
- site
- human breast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000481 breast Anatomy 0.000 title claims abstract description 218
- 230000003902 lesion Effects 0.000 title claims abstract description 170
- 238000000034 method Methods 0.000 title claims abstract description 55
- 238000001514 detection method Methods 0.000 title claims abstract description 48
- 238000005457 optimization Methods 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000012937 correction Methods 0.000 title claims abstract description 13
- 238000013461 design Methods 0.000 title abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 122
- 238000007385 chemical modification Methods 0.000 claims abstract description 38
- 238000010438 heat treatment Methods 0.000 claims abstract description 35
- 238000004088 simulation Methods 0.000 claims abstract description 27
- 206010037660 Pyrexia Diseases 0.000 claims abstract description 23
- 238000012360 testing method Methods 0.000 claims description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 28
- 239000000741 silica gel Substances 0.000 claims description 24
- 229910002027 silica gel Inorganic materials 0.000 claims description 24
- 239000002346 layers by function Substances 0.000 claims description 19
- 238000009826 distribution Methods 0.000 claims description 17
- 238000010146 3D printing Methods 0.000 claims description 15
- 238000007711 solidification Methods 0.000 claims description 12
- 230000008023 solidification Effects 0.000 claims description 12
- 239000000446 fuel Substances 0.000 claims description 10
- 239000002243 precursor Substances 0.000 claims description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 8
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 8
- 230000002792 vascular Effects 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 7
- 230000027950 fever generation Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 57
- 206010006187 Breast cancer Diseases 0.000 description 33
- 208000026310 Breast neoplasm Diseases 0.000 description 33
- 238000002474 experimental method Methods 0.000 description 22
- 229960001866 silicon dioxide Drugs 0.000 description 18
- 239000004205 dimethyl polysiloxane Substances 0.000 description 17
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 17
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 17
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 17
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 17
- 238000000338 in vitro Methods 0.000 description 16
- 230000001575 pathological effect Effects 0.000 description 16
- 230000008859 change Effects 0.000 description 14
- 238000005259 measurement Methods 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 12
- 206010028980 Neoplasm Diseases 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 238000012544 monitoring process Methods 0.000 description 9
- 210000005075 mammary gland Anatomy 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000011161 development Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012795 verification Methods 0.000 description 5
- 206010020843 Hyperthermia Diseases 0.000 description 4
- 238000005411 Van der Waals force Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000036031 hyperthermia Effects 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 244000137852 Petrea volubilis Species 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000013590 bulk material Substances 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 230000005186 women's health Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- -1 Dragonskin Substances 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012776 electronic material Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 229910021389 graphene Inorganic materials 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 150000003377 silicon compounds Chemical class 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000001931 thermography Methods 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Physics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Algebra (AREA)
- Computational Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mathematical Optimization (AREA)
- Medical Informatics (AREA)
- Pure & Applied Mathematics (AREA)
- Business, Economics & Management (AREA)
- Educational Administration (AREA)
- Educational Technology (AREA)
- Theoretical Computer Science (AREA)
- Instructional Devices (AREA)
- Prostheses (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
The present invention relates to a kind of prostheses imitating lesion breast and its design with preparation method, to the method for human breast lesion detection device optimization or check and correction.The prosthese of imitation lesion breast in the present invention, the wherein prosthese include prosthese main body and the simulation lesion site in prosthese main body.Prosthese main body is formed by the material of main part of apery body normal galactophore tissue, and it has the shape for imitating human breast.It includes one or more physics fever sites and/or one or more chemical modifications site to simulate lesion site, physics fever site is formed by flexible heating device, and the flexibility heating device has lead, wherein the flexible heating device of lead one end connection, the optionally other end expose from prosthese bottom part body.
Description
Technical field
The invention belongs to medical professionals's binding field, it is related to a kind of prosthese imitating lesion breast, imitates lesion breast
The design of prosthese and preparation method and the method to human breast lesion detection device optimization or check and correction.
Background technology
Female mammary gland is made of skin, fibr tissue, corpus mamma and fat, and breast cancer is to be happened at breast epithelium
The malignant tumour of tissue.Breast cancer has become one of the major malignant tumor for threatening women's health, and incidence is in female tumor
In ranked first, and it is in rising trend.Breast cancer has become the great public health problem of current social.
The prevention and treatment method of breast cancer can simply be attributed to physics class, chemical classes and the two and combine.Physics class
Method extensively using sound, light, power, electricity, the physical principles such as heat to the early screening of breast cancer, clinical diagnosis and treatment with it is postoperative
Medical assistance etc. played an important role.By taking breast cancer early detection as an example, clinically use at present and grinding
The method studied carefully includes:X-ray imaging, ultrasonic imaging, thermal imaging etc..The pathologic basis of these judgment methods is compared to normal group
It knits, sick cell and tissue metabolism are more vigorous so that diseased region local physical property (including hardness, temperature) and physiology
Tissue topography changes.
Threat due to the high incidence of breast cancer and its to women's health and living standard, with novel electron technology
Development and the foundation of Novel medical pattern, develop it is portable, wearable, long term monitoring or the medical treatment & health of breast cancer can be treated set
It is standby to realize that tele-medicine already becomes trend and hot spot with personalized medicine.In being studied for the electronic device of breast cancer medical treatment
The prosthese that human lesion mammary gland physical characteristic can accurately be imitated is most important for the value of extracorporeal simulating experiment.Lesion breast is false
Body is the variation of tissue substance reason characteristic in part when referring to simulation human breast lesion, including localized hyperthermia, local elasticity's modulus
Increase and indicative of local optical properties change etc..
However, existing breast prosthesis is substantially to be repaired for the breast after tumor resection at present, to improve
Curative effect is treated in tumor radical cure shaping and beauty, and quality of making the life better reduces medical treatment cost.It is based on for example, having been recorded in patent document 1
The breast prosthesis manufacturing method of three-dimensional printing technology, wherein treating excision according to the mammary gland medical image data of patient in the preoperative
Tumour carries out analyzing and positioning, determines shape, the size and location of cut-out, further utilize biological three-dimensional printing technology according to
Model prepares satisfactory personalized breast prosthesis.However, for breast prosthesis can be used for can long term monitoring or treatment breast
The medical treatment & health equipment of gland cancer is recorded there is no further.
Therefore, the sky that breast prosthesis carries out complementary medicine research, the precision of detection mode is also further promoted is utilized
Between.
Patent document 1:CN 104783924A
Invention content
Problems to be solved by the invention
Insufficient present on for this field, the technical problems to be solved by the invention are to be controlled to towards breast cancer monitoring
The research for the treatment of provides reliable experiment in vitro carrier, easily can optimize school with instrument to human breast location detection
It is accurate.
Prosthese based on 3D printing and flexible electronic Technology design and the imitation lesion breast prepared in the present invention has can
The function of the imitation human breast leaned on.Further, by using the prosthese for preparing of the present invention as experiment in vitro carrier, it can be achieved that
Accurate simulation and dynamic control of the lesion locations with lesion intensity, thus obtain the definite information about " lesion " degree, in turn
Personalization is carried out according to these information, is targetedly treated.
In addition, the present invention also aims to provide a kind of preparation method for the prosthese imitating lesion breast, it thus can root
According to the specific disease of patient, customization individual character particularly imitates the prosthese of lesion breast, the development shape of long term monitoring breast cancer
Condition or treatment breast cancer.
In addition, the present invention also aims to provide a kind of side to human breast lesion detection device optimization or check and correction
Method.Using the prosthese for imitating lesion breast as experiment in vitro carrier, units test is detected by novel human-body breast lesion and is somebody's turn to do
The information such as calorifics, the mechanics of prosthese, and further compared, thus optimized or proofreaded with the true detection data of the prosthese
Novel human-body breast lesion detects device.This method is to developing novel medical device and theoretical model for breast cancer with weight
Want meaning.The present invention can be used for but be not limited to the verification of the design and optimization and novel theoretical model of Novel electronic devices.
The solution to the problem
The present invention is based on 3D printing and flexible electronic technology, propose a kind of lesion breast prosthesis design and preparation method and
The thus obtained prosthese for imitating lesion breast.Especially by implementation of such as getting off.
Technical solution of the present invention is as follows:A kind of prosthese imitating lesion breast, the prosthese includes prosthese main body, and packet
The simulation lesion site being contained in prosthese main body, wherein
The prosthese main body is formed by the material of main part of apery body normal galactophore tissue, and it has imitation human breast
Shape;
The simulation lesion site includes one or more physics fever sites and/or one or more chemical modifications position
Point,
Physics fever site is formed by flexible heating device, and the flexible heating device has lead, wherein
The flexible heating device of lead one end connection, the optionally other end expose from the prosthese bottom part body.
According to above-described prosthese, wherein the material of main part of apery body normal galactophore tissue includes soft silica gel material
Material.
According to above-described prosthese, wherein the flexibility heating device includes micro-nano electronic device, the micro-nano electronics
There is device functional layer, the functional layer to include at least fuel factor functional layer.
According to above-described prosthese, wherein the prosthese has the one-dimensional heat conduction material of topological structure distribution, with mould
The form of anthropomorphic body mammary vascular distribution and arrange, the optionally at least one-dimensional heat conduction material of part is from the prosthese main body
Expose bottom.
Another technical solution of the present invention is as follows:A kind of preparation method for the prosthese imitating lesion breast, the method packet
Include following steps:
A) the step of forming the mold with human breast shape;
B) the step of forming the prosthese for imitating lesion breast in the mold,
The prosthese includes prosthese main body, and the simulation lesion site in prosthese main body, wherein
The prosthese main body is formed by the material of main part of apery body normal galactophore tissue, and it has imitation human breast
Shape;
The simulation lesion site includes one or more physics fever sites and/or one or more chemical modifications position
Point,
Physics fever site is formed by flexible heating device, and the flexible heating device has lead, wherein
The flexible heating device of lead one end connection, the optionally other end expose from the prosthese bottom part body.
According to the process described above, wherein forming the mold using 3D printing method in the step a).
According to the process described above, wherein the step b) includes the following steps:
I) liquid-state silicon gel precursor material is partially filled with into the inverted mold, it later will be before the liquid-state silicon gel
Body material solidification obtains soft silica gel material;
Ii) in the fixed one or more physics fevers site and/or one of above-mentioned soft silica gel material surface forming position
A or multiple chemical modifications site,
Repeat above-mentioned steps i) and ii), until the usable part of mold is filled, each soft silica gel material
Entirety form the prosthese main body.
According to the process described above, wherein in step ii) in, form the flexible heating device in physics fever site
Physics fits in the soft silica gel material surface in a manner of negative pressure and/or the chemical modification site passes through to described soft
Matter silica gel material surface carries out chemical modification processing and is formed.
Include being swept to the detection of the lesion breast of real human body wherein before step a) according to the process described above
It retouches, the detection scanning includes the specific location and volume of the shape and lesion that determine the true lesion breast.
According to the process described above, wherein being set according to the specific location of lesion and volume determined by the detection scanning
Set position and the volume of the simulation lesion site in the prosthese.
Further include that setting in the mold has wherein between step a) and step b) according to the process described above
There is the step of one-dimensional heat conduction material that topological structure is distributed, is arranged in the form of simulating human breast vascular distribution, optionally
At least part of one-dimensional heat conduction material exposes from the prosthese bottom part body.
The another technical solution of the present invention is as follows:A method of to human breast lesion detection device optimization or check and correction,
It includes the following steps:
The step of preparing to imitate the prosthese of lesion breast, the prosthese are according to above-described prosthese or according to above
The prosthese that the method obtains;
The step of obtaining the true detection data of the prosthese;
The prosthese is tested using to be optimized or check and correction human breast lesion detection device to obtain test number
According to the step of;
True detection data and the test data are compared, and then optimizes or proofread the human breast lesion detection device
The step of.
According to the process described above, wherein the true detection data and/or test data include thermal data, mechanics
Data, optical data or combinations thereof.
The effect of invention
Technical solution based on disclosure provided above, present invention obtains advantageous technique effects:Through the invention
The prosthese of the imitation lesion breast of offer can provide reliable experiment in vitro for the research towards breast cancer monitoring treatment and carry
Accurate simulation and dynamic control of the lesion locations with lesion intensity further can be achieved in body.In addition, pathomimia through the invention
Become the preparation method of the prosthese of breast, can according to the specific disease of patient, the state of development of long term monitoring breast cancer or
Treat breast cancer.In addition, the method to human breast lesion detection device optimization or check and correction through the invention, can optimize or school
It, thus can design and optimization Novel electronic devices and the novel theoretical model of verification to novel medical device.
Description of the drawings
Fig. 1 is the schematic diagram of lesion breast prosthesis structure involved in the present invention.
Fig. 2 is the schematic cross-section of micro-nano electronic device used in lesion breast prosthesis involved in the present invention.
Fig. 3 is the schematic diagram of micro-nano electronic device deformable structure used in lesion breast prosthesis involved in the present invention.
Fig. 4 is the preparation flow of lesion breast prosthesis involved in the present invention.
Fig. 5 is the application schematic diagram of lesion breast prosthesis involved in the present invention in vitro experiment.
Reference sign
In figure, 1- material of main parts;2- micro-nano electronic devices;Material of main part (chemical modification positions of the 3- Jing Guo chemical modification
Point);4- one-dimensional heat conduction materials;5- micro-nano electron device package layers;6- micro-nano electronic device functional layers;6a- serpentine curves;6b-
Extraction wire;7- micro-nano electronic substrate layers;8-3D printer nozzles;9- imitates Breast model;10- heating plates;11- testers
Part.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with attached drawing to embodiment party of the present invention
Formula is described in further detail.
<First embodiment>
The prosthese of lesion breast is imitated with preparation based on 3D printing and flexible electronic Technology design.
The first embodiment of the present invention provides a kind of prosthese imitating lesion breast comprising prosthese main body and packet
The simulation lesion site being contained in prosthese main body.Specifically, as shown in Figure 1, the prosthese for imitating lesion breast includes prosthese main body 1
With simulation lesion site 2,3.Prosthese main body 1 is formed by the material of main part of apery body normal galactophore tissue, and it has imitation
The shape of human breast.
It includes one or more physics fever sites 2 and/or one or more chemical modifications site 3 to simulate lesion site.
Specific to Fig. 1, physics fever site 2 is formed by flexible heating device, and the flexibility heating device has lead, wherein described draw
The flexible heating device of line one end connection, optionally, the other end exposes from the prosthese bottom part body.
The feature of prosthese for imitating lesion breast includes mainly:1) human breast pattern is imitated;2) the internal substance filled point
Two classes, an analoglike human normal breast tissue, another kind of simulated lesion breast tissue;3) object of apery body normal galactophore tissue
It is similar with human breast physical characteristic to manage characteristic, including elasticity modulus, thermal conductivity, imitates physical characteristic and the people of lesion breast tissue
Body lesion breast tissue physical characteristic is similar;4) the volume size and spatial position distribution for imitating lesion breast tissue can accurately dynamically
Control.
Prosthese main body 1 has the shape for imitating human breast.In the present invention, human breast is carried out using 3D scanning techniques
Scanning, establishes breast pattern threedimensional model, further prints the hard ghost with breast pattern using 3D printing technique, obtain
To imitative Breast model.Prosthese main body is formed in thus obtained imitative Breast model.
Prosthese main body mould personification body normal galactophore tissue, is formed by the material of main part 1 of apery body normal galactophore tissue.Apery
The physical characteristic of body normal galactophore tissue is similar with human breast physical characteristic, including elasticity modulus, thermal conductivity etc..Apery body is just
The material of main part 1 of normal breast tissue preferably includes soft silica gel material.Soft silica gel material can be consolidated by the silica-gel composition of liquid
Change and obtains.For example, high elastic polymer material usually can be used, such as silica gel PDMS,Dragonskin and
The materials such as hydrogel.
The polymer material of apery body normal galactophore tissue is not particularly limited in the present invention, can use be obtained commercially
Those of.For example, PDMS (dimethyl silicone polymer) is recognized under normal circumstances as a kind of the macromolecule organic silicon compound
It is nontoxic to be inertia, nonflammable, chemical stabilization.00-30,00-20,00-10 and 00-50 etc. are platinum catalysis systems
The especially soft silicon rubber made, hardness can be adjusted freely as needed.
By adjusting the concrete composition of polymer material, thermodynamic parameter (such as heat conduction of the material of main part after solidification can be made
Coefficient, thermal capacitance etc.) organized as far as possible with human breast average thermodynamic parameter similar or elasticity modulus as far as possible with human breast
Organize average elastic modulus close.As far as possible reach prosthese main body real surface when testing the performance parameter of pathological tissues in this way
The situation of human breast's tissue, keeps the background noise from prosthese main body as small as possible.
It includes one or more physics fever sites 2 and/or one or more chemical modifications site 3 to simulate lesion site.
It simulates lesion site and imitates lesion breast tissue, physical characteristic is similar with human lesion breast tissue physical characteristic.Physics is sent out
Thermal potential point is mainly formed by flexible heating device.Flexible heating device preferably includes micro-nano electronic device 2.
Micro-nano electronic device 2 has following characteristics:With fuel factor, its fuel factor can be controlled by circuit accurate quantification
Heat generates;Has flexible and ductility, unobvious change the mechanical property of lesion breast prosthesis entirety, can be deformable
It is worked normally in measuring environment;With with the approximate thermodynamic parameter of material of main part, it is whole that unobvious change lesion breast prosthesis
Heat transfer property.
Main function of the micro-nano electronic device 2 in lesion breast prosthesis be by the fever of electronic device accurately, can
Part caused by pathological tissues position is apparently higher than normal structure due to metabolism in regulation and control simulation human breast
High temperature.There is micro-nano electronic device 2 functional layer, the functional layer to include at least fuel factor functional layer.The thermal effect of micro-nano electronic device 2
Answer functional layer that can simulate localized hyperthermia caused by pathological tissues in human breast, Heating mechanism can be the joule effect of resistance wire
It answers, can also be the fuel factor of LED constant power devices.
As shown in Fig. 2, the basic structure of micro-nano electronic device 2 includes micro-nano electron device package layer 5, micro-nano electronic device
Functional layer 6 and micro-nano electronic substrate layer 7.Micro-nano electron device package layer 5 plays mechanically and electrically protective effect, micro-nano electronics
Device substrate layer 7 plays a supportive role, and the similar material institute made membrane of material of main part 1 both can be used, be not particularly limited.It is described
Functional layer includes at least fuel factor functional layer, and metal can be used as resistance wire or unencapsulated LED chip in fuel factor functional layer
Deng the electronic material with fuel factor.In addition, in some embodiments of the present invention, the functional layer is in addition to including fuel factor
Further include with the functional layers such as light or electricity other than functional layer.
As shown in figure 3, micro-nano electronic device 2 has flexible and ductility.The flexibility of micro-nano electronic device 2 passes through control
Each layer thickness is realized in micro-nano electronic device 2.The minimum bending radius of micro-nano electronic device 2 characterizes its flexible degree, this is most
Small-bend radius is determined by the ultimate strain value of material in thickness of detector and micro-nano electronic device functional layer 6.Micro-nano electronic device 2
Ductility by serpentine curve 6a as shown in the figure on micro-nano electronic substrate layer 7 from face bending deformation ensure.
The bending stiffness of flexibility requirements device is small, can easily be bent with adapt to material of main part 1 be possible to because
Localized hyperthermia and existing curvature.Ductility require device tensible rigidity it is small, can in face Direction distortion it is non-to adapt to
1 surface of material of main part that can be opened up.
Further, micro-nano electronic device 2 can have both multiple functions, including types of functionality element to conduct mechanics, optics etc.
Different signals.For example, the strain sensing component of semiconductor/metal piezoresistive effect, piezoelectric material buckling effect may be used
Energy harvesting components etc..
The size of micro-nano electronic device 2 is not particularly limited, as long as can match, simulate in human breast pathological tissues i.e.
It can.
In conjunction with Fig. 1 and Fig. 3, flexible heating device has lead 6b, wherein the flexible heating device of described lead one end connection,
That is micro-nano electronic device 2, optionally, the other end expose from the prosthese bottom part body, are connect with external circuitry.Reveal in lead 6b
In the case of going out, the signal of micro-nano electronic device 2 is connected with external circuitry by extraction wire 6b and realizes transmission and processing.
Chemical modification site 3 is the material of main part by chemical modification.Pass through the main body to apery body normal galactophore tissue
Material 1 carries out chemical modification processing, it can be achieved that the volume in chemical modification site 3 accurately may be used with modified power, heat, light property
Control.Main function of the material of main part in lesion breast prosthesis by chemical modification is simulation human breast lesion springform
The change of amount can also simulate change or the light of human breast lesion thermodynamic parameter in some embodiments of the present invention
Learn the change of property.
Material of main part by chemical modification has following characteristics:The chemical treatment being modified to it can be by designization
It learns reaction principle and the volume and modified power, heat, light property essence of the material of main part 3 Jing Guo chemical modification is realized in dosage control
It is really controllable.This modification can be realized by certain physical-chemical reaction.By taking PDMS as an example, ultraviolet light may be used in it
According to mode realize Surface hardened layer, can locally instill additional curing dose by way of realize hardening, part can also be passed through
Corona treatment realizes that indicative of local optical property changes.
The local physical property variation of simulation lesion site can be used one or more physics fever sites and/or one or
Multiple chemical modification sites carry out site-directed quantitative control.Further, the local physical property of imitative lesion breast tissue can be used embedding
Enter to decline nanometer electronic device and local chemical modification realization site-directed quantitative control.
When the prosthese of imitation lesion breast is studied for realizing breast cancer calorifics, the embedded micro-nano electronic device has
One of two features below:1) ultra-thin super soft extending, and device effective thermal conductivity and tissue are close;2) device volume is micro-
It is small.Features described above ensures that the insertion of the micro-nano electronic device in addition to realizing the adjustable of local temperature field, not appreciably affects disease
Become breast prosthesis entirety thermal capacitance and heat conduction parameters.When imitating the prosthese of lesion breast for realizing breast cancer mechanics study, institute
The firmness change of imitative lesion breast tissue can be reflected well by stating local chemical modification.Embedded micro-nano is controlled by site-directed quantitative
Electronic device and local chemical modification, state of development (" lesion " degree) of infallible simulation breast cancer etc..
In addition, if it is necessary, certain topological structure can be doped in material of main part in apery body normal galactophore tissue
The one-dimensional heat conduction material 4 of distribution simulates the blood vessel in human breast.One-dimensional heat conduction material 4 includes:Copper wire, silver wire etc. heat it is good
Conductor material.Certain topological structure refers to Major Vessels pattern in imitative human breast.
With reference to figure 1, one-dimensional heat conduction material 4 simulates the distribution of human breast medium vessels in lesion breast prosthesis.Human breast
In blood vessel can transmit heat by blood flow, there is similar human breast vascular distribution by increasing in material of main part 1
One-dimensional heat conduction material 4 can be simulated by its good heat conductivility the partial heat transmission.One-dimensional heat conduction material 4 have with
Lower feature:Thermal coefficient is substantially better than material of main part 1, can be processed into 3 dimension space network structures of certain configuration.One-dimensional heat conduction
The material that material 4 can select includes that metals, the nonmetallic materials such as carbon fiber, graphene such as silver, copper are not particularly limited.
Therefore, the one-dimensional heat conduction material with topological structure distribution in prosthese of the invention, to simulate human breast blood
Pipe distribution form and arrange, optionally at least the one-dimensional heat conduction material of part can expose from prosthese bottom part body.Pass through setting
Such one-dimensional heat conduction material can further make the calorifics, mechanics, optical property of the bionical prosthese in the present invention closer to true
The performance of lesion breast.
As a result, as shown in Figure 1, lesion breast prosthesis is the shape with imitative human breast.Lesion breast prosthesis mainly by
4 parts form below:Material of main part 1, micro-nano electronic device 2, the material of main part 3 by chemical modification and one-dimensional heat conduction material
Material 4.
The prosthese provided by the invention for imitating lesion breast can provide reliably for the research towards breast cancer monitoring treatment
Experiment in vitro carrier, the accurate of lesion locations and lesion intensity further can be achieved and simulate and dynamic control.
<Second embodiment>
Second embodiment of the present invention provides a kind of preparation method for the prosthese imitating lesion breast, the method packet
Include following steps:
A) the step of forming the mold with human breast shape;
B) the step of forming the prosthese for imitating lesion breast in the mold,
The prosthese includes prosthese main body and the simulation lesion site in prosthese main body.The prosthese main body by
The material of main part of apery body normal galactophore tissue is formed, and it has the shape for imitating human breast;The simulation lesion position
Point includes one or more physics fever sites and/or one or more chemical modifications site, and the physics generates heat site by soft
Heat pyrexia device is formed, and the flexible heating device has lead, wherein the flexible heating device of described lead one end connection,
Optionally, the other end exposes from the prosthese bottom part body.
Step a) is realized based on 3D scannings and printing technique.Imitative human breast pattern is scanned auxiliary with printing technique using 3D
Realization is helped, breast pattern threedimensional model file is established using 3D scanning techniques first, is then provided using 3D printing technique printing
There is the ghost of breast pattern.
Ghost with breast pattern is preferably hard ghost, becomes imitative Breast model.Printed material can select to commonly use
Rigid polymer printed material, such as resin.Commercially available resin can be used, this is not particularly limited.In order to make prosthese master
Body can easily be removed from imitative Breast model, can add releasing agent thereto, reduce obstruction when stripping.Alternatively, can also
Polishing ghost inner surface, keeps the contact interface between mold and prosthese main body smooth easily separated.It is beaten as a result, using 3D in step a)
Impression method forms imitative Breast model.
Further, step b) includes the following steps:
I) liquid-state silicon gel precursor material is partially filled with into inverted imitative Breast model, later by liquid-state silicon gel precursor
Material solidification obtains soft silica gel material;
Ii) in the fixed one or more physics fevers site and/or one of above-mentioned soft silica gel material surface forming position
A or multiple chemical modifications site,
Repeat above-mentioned steps i) and ii), until the usable part of mold is filled, each soft silica gel material
All form prosthese main body.
Step i) progress specific as follows:Specific location and number of the pathological tissues in breast are determined, in imitative Breast model
The water of same height is poured at the height of middle pathological tissues design position, and the volume of water at this time is recorded using graduated cylinder;It obtains every
Liquid volume corresponding to a pathological tissues position height is corresponding in turn to the apery phosphor bodies material bodies of different height from top to bottom
Product, number A, B, C ...
Further, the material of main part 1 for weighing the apery body normal galactophore tissue that volume is A pours into imitative Breast model 9, and
And make its solidification.
Liquid-state silicon gel precursor material has following characteristics:Curable high molecular polymer has high resiliency, heat after solidification
Mechanics parameter (such as thermal coefficient, thermal capacitance etc.) organizes average thermodynamic parameter similar or elasticity modulus and human body breast with human breast
Glandular tissue average elastic modulus is close.Cure liquid silica precursor material and obtain soft silica gel material, is i.e. material of main part 1.Such as
Upper described, PDMS can be used in material of main part 1,The silicon rubber high molecular material such as Dragonskin, hydrogel etc..
Step ii) it can carry out as follows:After the solidification of liquid-state silicon gel precursor material, micro-nano electricity is placed in corresponding horizontal plane position
Sub- device 2 changes such as imitation leather skin resistive element, or in corresponding horizontal plane position (such as at the surface of material of main part 1 3) application chemistry
Property processing obtain chemical modification site 3.
Include the scanning of the detection to the lesion breast of real human body in addition, before step a), detection scanning includes determining
The shape of true lesion breast and the specific location and volume of lesion.The tool of identified lesion is scanned according to detection as a result,
The position for the simulation lesion site that body position and volume are arranged in the prosthese for imitating lesion breast and volume.
Above-mentioned detection scanning can be carried out by 3D scanning techniques.Imageological examination is can be combined with, including mammary X-ray is taken the photograph
Shadow (breast molybdenum target photograph), color ultrasound, can also carry out mammary gland magnetic resonance inspection (MRI) when necessary.According to having built up and relatively complete
Kind means determine the specific location and volume of lesion.Further, it is possible to be designed according to known Modeling Theory to be prepared
Imitation lesion breast prosthese specific pattern.
The preparation method of the prosthese of the imitation lesion breast of the present invention can further be wrapped between step a) and step b)
Including setting in a mold has the step of one-dimensional heat conduction material of topological structure distribution, to simulate the shape of human breast vascular distribution
State and arrange, optionally so that at least part of one-dimensional heat conduction material expose from the prosthese bottom part body.
As described above, one-dimensional heat conduction material has following characteristics:Thermal coefficient is substantially better than apery body normal galactophore tissue
Material of main part 1, and 3 dimension space network structures of certain configuration can be processed into.Have by increasing in material of main part
The one-dimensional heat conduction material of similar human breast vascular distribution can simulate partial heat transmission by its good heat conductivility.
So can more accurately simulated lesion breast, also can more accurately detect the signal of pathological tissues.
From the 6 of Fig. 4) in as it can be seen that it is finally obtained imitate lesion breast prosthese include prosthese main body 1 and included in vacation
Simulation lesion site 2,3 in phosphor bodies.Prosthese main body 1 is formed by the material of main part 1 of apery body normal galactophore tissue, and its
With the shape for imitating human breast.It includes one or more micro-nano electronic devices 2 and/or one or more to simulate lesion site
Chemical modification site 3.There is micro-nano electronic device 2 lead, one end of lead to connect micro-nano electronic device, optionally, the other end
Expose from the bottom of prosthese main body 1.
In addition, in step ii) in, formation haircut thermal potential point flexible heating device in a manner of negative pressure physics fit in
Soft silica gel material surface and/or chemical modification site pass through the shape to the progress chemical modification processing of soft silica gel material surface
At.The mode of the negative pressure, such as can refer to being formed the surface that flexible heating device is contacted with soft silica gel using equipment
Vacuum state so that the two is connected with Van der Waals force.And when such connection type subsequently to reinject material of main part
Undesirable displacement will not occur for flexible heating device.
In step ii) in, flexible heating device is maintained in the state of negative pressure on soft silica gel material surface, thus
Can be closely integrated with material of main part 1 by Van der Waals force, avoid the precursor material of follow-up bulk material pour into and it is solid
Change and changes its position.Thus, it can be achieved that pathological tissues spatial positions is precisely controlled in lesion breast prosthesis.
Chemical modification processing can be realized by certain physical-chemical reaction.It can be according to the reality of breast lesion tissue
Situation designs chemical modification reaction principle and controls modification degree.For example, the mode that ultraviolet lighting may be used realizes surface
Hardening can realize hardening by way of locally instilling additional curing dose, can also be handled and be realized by local plasma
Indicative of local optical property changes.
The soft Silica Surface handled by chemical modification accurately controls its volume and power, heat, light property, simulates human body
The change of elasticity modulus or the change of thermodynamic parameter or the change of optical property at breast lesion.
The preparation method of the prosthese of imitation lesion breast through the invention, can be long according to the specific disease of patient
Phase monitors the state of development or treatment breast cancer of breast cancer, realizes personalized medicine.
As shown in figure 4, the preparation flow of lesion breast prosthesis can be divided into following steps:
1) human breast is scanned using 3D scanning techniques, establishes breast pattern threedimensional model;As shown in Fig. 4 (1),
The hard ghost with breast pattern is printed from printer nozzle 8 using 3D printing technique, obtains imitative Breast model 9.It beats
Print material can select common rigid polymer printed material, such as resin.When 3D printing, breast threedimensional model need to be adjusted and be had
There is certain thickness ghost, such as 1mm thickness.9 surface of Breast model can be imitated to printing gained to polish, make with sand paper if necessary
Its is smooth.If have ready-made breast threedimensional model, 3D scanning modelings process can remove from.
2) if it is necessary, the step of increasing doped one-dimensional Heat Conduction Material 4 after the 1) step.
3) specific location and number of the pathological tissues in breast are determined according to experiment in vitro demand.As shown in Fig. 4 (2),
Breast model nipple is placed downward, and fixed, is poured into equally at the height of pathological tissues design position in imitative Breast model
The water of height, and utilization graduated cylinder records the volume of water at this time;Liquid volume corresponding to each pathological tissues position height is obtained, from
Under to the apery phosphor bodies material volume for being above corresponding in turn to different height, number A, B, C ...
4) material of main part 1 for the apery body normal galactophore tissue that volume is A is weighed, and is poured into imitative Breast model.
5) after the solidification of the material of main part 1 of A volumes, micro-nano electronics is placed in the corresponding position of pathological tissues on the horizontal plane
Device 2.Vacuumize the air excluded between the two interface so that micro-nano electronic device 2 can rely on Van der Waals force and main body material
Material 1 is closely integrated, and avoid follow-up bulk material 1 pours into and cure the position for changing micro-nano electronic device 2.Realize lesion
Pathological tissues spatial position is precisely controlled in breast prosthesis.
6) or after the solidification of material of main part 1, the corresponding position of pathological tissues applies chemical modification and handles in the horizontal plane
To the material of main part 3 Jing Guo chemical modification, as shown in Fig. 4 (3).
7) step 4,5 and/or 6 are repeated, are filled up by material of main part 1 until imitating Breast model 9, such as Fig. 4 (4) or Fig. 4 (5) institute
Show.
8) the lesion breast prosthesis that solidification is completed is demoulded from imitative Breast model 9, obtains final lesion breast prosthesis,
As shown in Fig. 4 (6).It completes to prepare.
<Third embodiment>
Third embodiment of the present invention provides a kind of method to human breast lesion detection device optimization or check and correction,
It includes the following steps:
The step of preparing to imitate the prosthese of lesion breast, prosthese is above-mentioned prosthese or passes through the vacation of above method acquisition
Body;
The step of obtaining the true detection data of prosthese;
Prosthese is tested to obtain test data using to be optimized or check and correction human breast lesion detection device
Step;
True detection data and test data are compared, and then the step of optimizing or proofreading human body breast lesion detection device.
As shown in figure 5, when the prosthese of the present invention for imitating lesion breast is used for breast cancer experiment in vitro, it can be by lesion breast
For room prosthese as in heating plate 10, temperature of heating plate is adjusted to 37 DEG C of simulation human body basal body temperatures;Test device 11 is integrated in lesion
Breast prosthesis surface.Test device 11 provides imitative lesion group by parameters such as calorifics, mechanics, the optics of measurement lesion breast prosthesis
The spatial position knitted and " lesion " degree." lesion " organizational parameter (including position and intensity) is surveyed by contrast test device 11
It, can be to test device 11 and based on the breast cancer detection for testing device 11 with true " lesion " organizational parameter in lesion breast prosthesis
Technology is tested and is optimized.It is preferably the novel medical device according to new theoretical model design to test device 11.
True detection data and/or test data include thermal data, Mechanical Data, optical data or combinations thereof.It utilizes
The prosthese of above-mentioned imitation lesion breast of the invention measures true detection data and test data respectively as experiment in vitro carrier
And it is compared, thus quick response human breast lesion detection device can be adjusted.
In the new theoretical model of design and optimization Novel electronic devices and verification, method through the invention can facilitate
Novel electronic devices are easily transformed and improve new detection mechanism.
<Embodiment>
Specific embodiment is as follows.
Embodiment a:Lesion breast prosthesis a
The present embodiment using 3D printing technique and flexible electronic Technology design and will prepare the mammary gland based on calorifics principle
Cancer detects the lesion breast prosthesis of experiment in vitro, can be used for the test of the breast cancer detection device performance based on calorifics principle with it is excellent
Change and the verification of breast cancer detection mechanism based on calorifics principle.The lesion breast prosthesis can quantify positioning simulation human body
When lesion tissue metabolism acutely, heat build-up and the conducting heat model of localized hyperthermia that generates.
First, test patient a is chosen as subjects, and the breast for testing patient a is swept using 3D scanning techniques
It retouches, establishes breast pattern threedimensional model.The three-dimensional breast model ghost of resin material, breast and chest are printed using 3D printing technique
Portion's intersection is open for ghost model.Phantom thicknesses are 1mm.With dry sanding paper polishing ghost inner surface, keep its smooth.
The opening up placement of breast model ghost that will be printed.According to test experiments scheme, each " lesion " tissue is determined
Spatial position.Water is poured into ghost successively, liquid level is made to be flushed with spatial position where " lesion " tissue, by weighing water at this time
Volume obtain the material of main part volume that the position height should be poured into, and bulking value is numbered from low to high according to spatial position
For A, B, C ....Dry breast model ghost.
Material of main part selects PDMS.The PDMS that volume is A is poured into breast model ghost, standing waits for that PDMS cures.According to
According to the above-mentioned 3 d scan data of patient a, the corresponding position in the surfaces PDMS after hardening is placed using flexible electronic technology system
The standby extending resistance device of flexibility.The bubble for excluding the two interface is vacuumized, makes device can be with PDMS by Van der Waals force
Surface is realized and is closely integrated, and avoids follow-up liquid PDMS's from pouring into and cure change device position.It repeats the above steps, Zhi Daomo
Quasi- " lesion " tissue for completing all patient a, and PDMS fills up breast model ghost.
After PDMS is fully cured, by itself and mould separating, the breast cancer detection experiment in vitro based on calorifics principle is obtained
Lesion breast prosthesis a.Since the resistance value R of device is certain, the calorific value Q of local location can use joule formula Q=in prosthese
I2R carries out quantitative calculating.Simultaneously by control device by electric current I size, the calorific value of local location can be realized
The control of dynamic quantitative.
Prosthese a is tested using measurement device, by test value and actual value to compare the measurement device into
Row calibration or optimization.
Therefore, use the lesion breast prosthesis not only can be to the nature static of measurement device as breast cancer experiment in vitro carrier
Matter measures and optimizes, and can also have measurement and optimization function for the dynamic response characteristic of measurement device.
Embodiment b:Lesion breast prosthesis b
Other than selecting to test patient b as subjects, obtained in a manner of identical with embodiment a former based on calorifics
The lesion breast prosthesis b of the breast cancer detection experiment in vitro of reason.
Using measurement device, in a manner of identical with embodiment a, lesion breast prosthesis b is detected.In conjunction with lesion breast
The truthful data of room prosthese b measures and optimizes to the static nature and dynamic response characteristic of measurement device.
Embodiment c:Lesion breast prosthesis c
The present embodiment using 3D printing technique and flexible electronic Technology design and will prepare the mammary gland based on calorifics principle
Cancer detects the lesion breast prosthesis of experiment in vitro.
According to ready-made breast pattern threedimensional model, resin material is printed using 3D printing technique, obtains hard ghost
Imitative Breast model.Breast is mould openings, thickness 1mm with chest intersection.With sand paper to gained imitate Breast model surface into
Row polishing, keeps its smooth.
One-dimensional heat conduction material is arranged in imitative Breast model, imitates the vascular distribution in breast, and make it can be from prosthese
Expose the bottom of main body.
Based on spatial position, volume size and the lesion degree of each preset " lesion " tissue, test experiments scheme is designed
c.By the opening up placement of the ghost of the imitative Breast model printed.Choose main bodys of the PDMS as apery body normal galactophore tissue
Material.The PDMS of certain volume is poured into imitative Breast model, standing waits for its solidification.Rule are designed on the surfaces PDMS after hardening
The extending resistance device of flexibility prepared using flexible electronic technology is placed in the position drawn, and vacuumizes both exclusions interface
Bubble, so that device and the surfaces PDMS is realized and be closely integrated.It repeats the above steps, until completing all " lesions " being pre-designed
The integrated and PDMS of device fills up imitative Breast model ghost at tissue.
The lesion breast prosthesis that solidification is completed is demoulded from imitative Breast model, finally obtains the mammary gland based on calorifics principle
Cancer detects the lesion breast prosthesis c of experiment in vitro, completes to prepare.
Prosthese c is tested using measurement device, by test value and actual value to compare the measurement device into
Row calibration or optimization.
Embodiment d:Lesion breast prosthesis d
(flexibility for changing test experiments scheme c in embodiment c can other than designing other test experiments scheme d
The position of spreading resistance device), it is external that the breast cancer detection based on calorifics principle is obtained in a manner of identical with embodiment c
The lesion breast prosthesis d of experiment.
Prosthese c is tested using measurement device, by test value and actual value to compare the measurement device into
Row calibration or optimization.
Further above example is prepared for 4 group models, therefore, can be based on any of which one or more models
The comparison of the test data of truthful data and measurement device, from static state to dynamic optimization measurement device.Therefore, by designing disease
Become breast prosthesis, and as breast cancer experiment in vitro carrier, human breast lesion detection device can be adjusted
Or optimization.
It will be appreciated by those skilled in the art that attached drawing is the schematic diagram of a preferred embodiment, the embodiments of the present invention
Serial number is for illustration only, can not represent the quality of embodiment.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Industrial availability
The prosthese of the imitation lesion breast provided through the invention can provide for the research towards breast cancer monitoring treatment
Accurate simulation and dynamic control of the lesion locations with lesion intensity further can be achieved in reliable experiment in vitro carrier.In addition, logical
The preparation method for crossing the prosthese of the imitation lesion breast of the present invention, can be according to the specific disease of patient, long term monitoring mammary gland
The state of development or treatment breast cancer of cancer.In addition, through the invention to human breast lesion detection device optimization or check and correction
Method, can optimize or proofread novel medical device, thus can design and optimization Novel electronic devices and the novel theory of verification
Model.
Claims (13)
1. a kind of prosthese imitating lesion breast, which is characterized in that the prosthese includes prosthese main body, and is included in prosthese master
Internal simulation lesion site, wherein
The prosthese main body is formed by the material of main part of apery body normal galactophore tissue, and it has the outer of imitation human breast
Shape;
The simulation lesion site includes one or more physics fever sites and/or one or more chemical modifications site,
Physics fever site is formed by flexible heating device, and the flexible heating device has lead, wherein described
The flexible heating device of lead one end connection, the optionally other end expose from the prosthese bottom part body.
2. prosthese according to claim 1, which is characterized in that the material of main part of apery body normal galactophore tissue includes
Soft silica gel material.
3. prosthese according to claim 1 or 2, which is characterized in that the flexibility heating device includes micro-nano electronic device,
There is the micro-nano electronic device functional layer, the functional layer to include at least fuel factor functional layer.
4. according to claim 1-3 any one of them prostheses, which is characterized in that the prosthese has the one of topological structure distribution
Heat Conduction Material is tieed up, is arranged in the form of simulating human breast vascular distribution, optionally at least the one-dimensional heat conduction of part
Material exposes from the prosthese bottom part body.
5. a kind of preparation method for the prosthese imitating lesion breast, which is characterized in that described method includes following steps:
A) the step of forming the mold with human breast shape;
B) the step of forming the prosthese for imitating lesion breast in the mold,
The prosthese includes prosthese main body, and the simulation lesion site in prosthese main body, wherein
The prosthese main body is formed by the material of main part of apery body normal galactophore tissue, and it has the outer of imitation human breast
Shape;
The simulation lesion site includes one or more physics fever sites and/or one or more chemical modifications site,
Physics fever site is formed by flexible heating device, and the flexible heating device has lead, wherein described
The flexible heating device of lead one end connection, the optionally other end expose from the prosthese bottom part body.
6. according to the method described in claim 5, it is characterized in that, forming the mould using 3D printing method in the step a)
Tool.
7. method according to claim 5 or 6, which is characterized in that the step b) includes the following steps:
I) liquid-state silicon gel precursor material is partially filled with into the inverted mold, later by the liquid-state silicon gel precursor material
Material solidification obtains soft silica gel material;
Ii) in the fixed one or more physics fever sites of above-mentioned soft silica gel material surface forming position and/or one or
Multiple chemical modification sites,
Repeat above-mentioned steps i) and ii), until the usable part of mold is filled, each soft silica gel material it is complete
Body forms the prosthese main body.
8. the method according to the description of claim 7 is characterized in that in step ii) in, form the soft of physics fever site
It is logical that heat pyrexia device physics in a manner of negative pressure fits in the soft silica gel material surface and/or the chemical modification site
It crosses and chemical modification processing is carried out to the soft silica gel material surface and is formed.
9. according to claim 5-8 any one of them methods, which is characterized in that before step a), including to real human body
Lesion breast detection scanning, the detection scanning include the determination true lesion breast shape and lesion it is specific
Position and volume.
10. according to the method described in claim 9, it is characterized in that, according to the specific of lesion determined by the detection scanning
The position for the simulation lesion site that position and volume are arranged in the prosthese and volume.
11. according to claim 5-10 any one of them methods, which is characterized in that between step a) and step b), also wrap
Including setting in the mold has the step of one-dimensional heat conduction material of topological structure distribution, to simulate human breast vascular distribution
Form and arrange, the one-dimensional heat conduction material of optionally at least part exposes from the prosthese bottom part body.
12. a kind of method to human breast lesion detection device optimization or check and correction, which is characterized in that include the following steps:
The step of preparing to imitate the prosthese of lesion breast, the prosthese be according to claim 1-4 any one of them prosthese or
The prosthese that person obtains according to any one of claim 5-11 the methods;
The step of obtaining the true detection data of the prosthese;
The prosthese is tested to obtain test data using to be optimized or check and correction human breast lesion detection device
Step;
True detection data and the test data are compared, and then optimizes or proofread the step of the human breast lesion detection device
Suddenly.
13. according to the method for claim 12, which is characterized in that the true detection data and/or test data include
Thermal data, Mechanical Data, optical data or combinations thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810394619.3A CN108447370B (en) | 2018-04-27 | 2018-04-27 | Diseased breast prosthesis, preparation method and breast detector optimization or calibration method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810394619.3A CN108447370B (en) | 2018-04-27 | 2018-04-27 | Diseased breast prosthesis, preparation method and breast detector optimization or calibration method |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108447370A true CN108447370A (en) | 2018-08-24 |
CN108447370B CN108447370B (en) | 2020-01-21 |
Family
ID=63201897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810394619.3A Active CN108447370B (en) | 2018-04-27 | 2018-04-27 | Diseased breast prosthesis, preparation method and breast detector optimization or calibration method |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108447370B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109523887A (en) * | 2018-12-29 | 2019-03-26 | 北京工业大学 | A kind of preparation method of the bionical vascular pattern of high transparency for hydrodynamics observation experiment |
CN111223374A (en) * | 2020-03-12 | 2020-06-02 | 吉林大学 | Demonstration device for minimally invasive surgery model of Maimengtong |
CN114012943A (en) * | 2021-10-21 | 2022-02-08 | 上海海洪医疗科技发展有限公司 | Method for customizing personalized silica gel prosthesis mold based on MRI (magnetic resonance imaging) image data |
CN116392100A (en) * | 2023-06-08 | 2023-07-07 | 中国科学技术大学先进技术研究院 | Special imitative body for magnetic resonance guided mammary gland intervention and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004191788A (en) * | 2002-12-12 | 2004-07-08 | Yoko Takara | Breast massage practice device |
CN103700305A (en) * | 2013-11-29 | 2014-04-02 | 中国人民解放军第四军医大学 | Breast rheid model applied to mammary gland impedance scanning detection technique training and preparation |
CN205251520U (en) * | 2015-12-03 | 2016-05-25 | 河北百富勤生物科技有限公司 | Through measuring device that breast surface temperature judges breast disease |
CN106847037A (en) * | 2017-04-05 | 2017-06-13 | 吉林大学 | A kind of body mould and its preparation for mammary gland Microcalcification clinical training |
CN106937865A (en) * | 2017-03-27 | 2017-07-11 | 成都柏森松传感技术有限公司 | Can early warning breast lesion temperature monitoring system and monitoring method |
-
2018
- 2018-04-27 CN CN201810394619.3A patent/CN108447370B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004191788A (en) * | 2002-12-12 | 2004-07-08 | Yoko Takara | Breast massage practice device |
CN103700305A (en) * | 2013-11-29 | 2014-04-02 | 中国人民解放军第四军医大学 | Breast rheid model applied to mammary gland impedance scanning detection technique training and preparation |
CN205251520U (en) * | 2015-12-03 | 2016-05-25 | 河北百富勤生物科技有限公司 | Through measuring device that breast surface temperature judges breast disease |
CN106937865A (en) * | 2017-03-27 | 2017-07-11 | 成都柏森松传感技术有限公司 | Can early warning breast lesion temperature monitoring system and monitoring method |
CN106847037A (en) * | 2017-04-05 | 2017-06-13 | 吉林大学 | A kind of body mould and its preparation for mammary gland Microcalcification clinical training |
Non-Patent Citations (1)
Title |
---|
赵先武等: "用于显示乳房局部病灶组织红外热图像的伪彩色方法", 《光谱学与光谱分析》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109523887A (en) * | 2018-12-29 | 2019-03-26 | 北京工业大学 | A kind of preparation method of the bionical vascular pattern of high transparency for hydrodynamics observation experiment |
CN111223374A (en) * | 2020-03-12 | 2020-06-02 | 吉林大学 | Demonstration device for minimally invasive surgery model of Maimengtong |
CN114012943A (en) * | 2021-10-21 | 2022-02-08 | 上海海洪医疗科技发展有限公司 | Method for customizing personalized silica gel prosthesis mold based on MRI (magnetic resonance imaging) image data |
CN116392100A (en) * | 2023-06-08 | 2023-07-07 | 中国科学技术大学先进技术研究院 | Special imitative body for magnetic resonance guided mammary gland intervention and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN108447370B (en) | 2020-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108447370A (en) | It imitates the prosthese of lesion breast and its designs with preparation method, to the method for human breast lesion detection device optimization or check and correction | |
Song et al. | Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue | |
Zhang et al. | Theoretical and experimental studies of epidermal heat flux sensors for measurements of core body temperature | |
Cui et al. | Haptically quantifying Young's modulus of soft materials using a self‐locked stretchable strain sensor | |
US7419376B2 (en) | Human tissue phantoms and methods for manufacturing thereof | |
US20100047752A1 (en) | Anatomically and functionally accurate soft tissue phantoms and method for generating same | |
WO2012006431A2 (en) | Apparatus and method for surface and subsurface tactile sensation imaging | |
CN104783924A (en) | Breast prosthesis manufacturing method based on three-dimensional printing technology | |
CN109708782B (en) | Knee joint prosthesis gasket three-dimensional force sensor and contact stress measuring method thereof | |
Li et al. | Mechanical imaging of soft tissues with a highly compliant tactile sensing array | |
Mojra et al. | A novel haptic robotic viscogram for characterizing the viscoelastic behaviour of breast tissue in clinical examinations | |
JP3885024B2 (en) | Device for direct contact diagnosis of patients in non-contact position | |
Bhatti et al. | A novel breast software phantom for biomechanical modeling of elastography | |
CN203647326U (en) | Tumor palpation diagnostic apparatus | |
Briot et al. | In vivo measurement of breast tissues stiffness using a light aspiration device | |
Ng et al. | A multilayered, lesion-embedded ultrasound breast phantom with realistic visual and haptic feedback for needle biopsy | |
CN205083444U (en) | Palpation probe | |
Rajagopal | Modelling breast tissue mechanics under gravity loading | |
Chanda et al. | Tissues in functional organs—low stiffness | |
CN114191144A (en) | 3D physical copy of cardiac structure and manufacturing method thereof | |
Borghetti et al. | Measuring inside your mouth! Measurement approaches, design considerations, and one example for tongue pressure monitoring | |
Bira et al. | Measurement of tissue stiffness using soft EGA-in sensors and pressure application | |
Duraes et al. | Evaluation of breast skin and tissue stiffness using a non‐invasive aspiration device and impact of clinical predictors | |
Damiani et al. | Rapid prototyping of an elastic bladder model for in-vitro simulation of the transurethral resection of the prostate | |
CN208477810U (en) | A kind of body mould |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190311 Address after: 100084 Tsinghua Yuan, Haidian District, Beijing, No. 1 Applicant after: Tsinghua University Applicant after: Zhejiang Tsinghua Flexible Electronic Technology Research Institute Address before: 100084 Tsinghua Yuan, Haidian District, Beijing, No. 1 Applicant before: Tsinghua University |
|
GR01 | Patent grant | ||
GR01 | Patent grant |